Gossypose (BioDeep_00000860005)

Main id: BioDeep_00000000289

 

PANOMIX_OTCML-2023


代谢物信息卡片


(2R,3R,4S,5S,6R)-2-[[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)-2-tetrahydrofuranyl]oxy]-6-[[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxymethyl]tetrahydropyran-3,4,5-triol

化学式: C18H32O16 (504.1690272)
中文名称: 棉籽糖
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(C1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3(C(C(C(O3)CO)O)O)CO)O)O)O)O)O)O)O
InChI: InChI=1S/C18H32O16/c19-1-5-8(22)11(25)13(27)16(31-5)30-3-7-9(23)12(26)14(28)17(32-7)34-18(4-21)15(29)10(24)6(2-20)33-18/h5-17,19-29H,1-4H2/t5-,6-,7-,8+,9-,10-,11+,12+,13-,14-,15+,16+,17-,18+/m1/s1

描述信息

COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Raffinose (Melitose), a non-digestible short-chain?oligosaccharide, is a trisaccharide composed of galactose, glucose, and fructose and can be found in many plants. Raffinose (Melitose) can be hydrolyzed to D-galactose and sucrose by the enzyme α-galactosidase (α-GAL)[1].
Raffinose (Melitose), a non-digestible short-chain?oligosaccharide, is a trisaccharide composed of galactose, glucose, and fructose and can be found in many plants. Raffinose (Melitose) can be hydrolyzed to D-galactose and sucrose by the enzyme α-galactosidase (α-GAL)[1].

同义名列表

23 个代谢物同义名

(2R,3R,4S,5S,6R)-2-[[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)-2-tetrahydrofuranyl]oxy]-6-[[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxymethyl]tetrahydropyran-3,4,5-triol; (2R,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)tetrahydrofuran-2-yl]oxy-6-[[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxymethyl]tetrahydropyran-3,4,5-triol; (2R,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-dimethylol-tetrahydrofuran-2-yl]oxy-6-[[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxymethyl]tetrahydropyran-3,4,5-triol; (2R,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-6-[[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxane-3,4,5-triol; alpha-D-Glucopyranoside, beta-D-fructofuranosyl O-alpha-D-galactopyranosyl-(1>6)- (9CI); O-alpha-D-Galactopyranosyl(1,6)-O-alpha-D-glucopyranosyl-(1,2)-beta-D-fructofuranoside; alpha-D-Glucopyranoside, beta-D-fructofuranosyl O-alpha-D-galactopyranosyl (1 to 6)-; alpha-D-glucopyranoside, beta-D-fructofuranosyl O-alpha-D-galactopyranosyl-(1->6)-; beta-D-Fructofuranosyl-O-alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside; beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside; alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranosyl beta-D-fructofuranoside; alpha-D-Galp-(1->6)-alpha-D-Glcp-(1->2)-beta-D-Fruf; 6G-alpha-D-galactosylsucrose; Melitriose, Raffinose; AIDS-014662; CHEBI:16634; 17629-30-0; AIDS014662; Gossypose; Raffinose; 512-69-6; C00492; Melitose



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(5)

PlantCyc(5)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

88 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Danhui Dong, Chuandong Qi, Jialong Zhang, Qilin Deng, Pingxin Xia, Ping Li, Congyang Jia, Bing Zhao, Na Zhang, Yang-Dong Guo. CsHSFA1d Promotes Drought Stress Tolerance by Increasing the Content of Raffinose Family Oligosaccharides and Scavenging Accumulated Reactive Oxygen Species in Cucumber. Plant & cell physiology. 2024 May; 65(5):809-822. doi: 10.1093/pcp/pcae023. [PMID: 38564325]
  • Pan Shu, Yujing Li, Jiping Sheng, Lin Shen. Tomato SlMAPK3 Modulates Cold Resistance by Regulating the Synthesis of Raffinose and the Expression of SlWRKY46. Journal of agricultural and food chemistry. 2024 Mar; 72(10):5185-5196. doi: 10.1021/acs.jafc.3c09066. [PMID: 38427575]
  • Avriti Ranjan, Rahul Michael, Swati Gautam, Prabodh Kumar Trivedi. HY5-dependent light-mediated regulation of galactinol synthase gene, AtGolS1, modulates galactinol biosynthesis in Arabidopsis. Biochemical and biophysical research communications. 2024 Feb; 695(?):149423. doi: 10.1016/j.bbrc.2023.149423. [PMID: 38157630]
  • Gongsheng Zhang, Mingxue He, Lihong Xiao, Yuehua Jiao, Jianchun Han, Chun Li, Michael J Miller, Lili Zhang. Milk fat globule membrane protects Bifidobacterium longum ssp. infantis ATCC 15697 against bile stress by modifying global transcriptional responses. Journal of dairy science. 2024 Jan; 107(1):91-104. doi: 10.3168/jds.2023-23591. [PMID: 37678788]
  • Huizhi Li, Shishan Zhang, Yanfang Zhao, Jixiang He, Xiangfeng Chen. Identification of raffinose family oligosaccharides in processed Rehmannia glutinosa Libosch using matrix-assisted laser desorption/ionization mass spectrometry image combined with machine learning. Rapid communications in mass spectrometry : RCM. 2023 Nov; 37(22):e9635. doi: 10.1002/rcm.9635. [PMID: 37817339]
  • Madison E Calvert, Samantha A Molsberry, Kirsten E Overdahl, Alan K Jarmusch, Natalie D Shaw. Pubertal girls with overweight/obesity have higher androgen levels - can metabolomics tell us why?. The Journal of clinical endocrinology and metabolism. 2023 Nov; ?(?):. doi: 10.1210/clinem/dgad675. [PMID: 37978828]
  • Haitian Fu, Ying Zhao, Jianqi Huang, Yanchun Luo, Zusheng Wei, Benchi Yu, Feng Wen. Reduced glutathione and raffinose lengthens postharvest storage of cassava root tubers by improving antioxidant capacity and antibiosis. BMC plant biology. 2023 Oct; 23(1):475. doi: 10.1186/s12870-023-04466-7. [PMID: 37807058]
  • Juan Song, Yue Liu, Xiangchang Yin, Yi Nan, Yuhao Shi, Xiaojuan Chen, Haizhen Liang, Jie Zhang, Baiping Ma. Isolation and structural elucidation of prebiotic oligosaccharides from Ziziphi Spinosae Semen. Carbohydrate research. 2023 Sep; 534(?):108948. doi: 10.1016/j.carres.2023.108948. [PMID: 37783055]
  • Niklas Reichelt, Arthur Korte, Markus Krischke, Martin J Mueller, Daniel Maag. Natural variation of warm temperature-induced raffinose accumulation identifies TREHALOSE-6-PHOSPHATE SYNTHASE 1 as a modulator of thermotolerance. Plant, cell & environment. 2023 Jul; ?(?):. doi: 10.1111/pce.14664. [PMID: 37427798]
  • Stefan Ritter, Martina Gastl, Thomas Becker. Impact of Germination on the Protein Solubility and Antinutritive Compounds of Lupinus angustifolius and Vicia faba in the Production of Protein-Rich Legume-Based Beverages. Journal of agricultural and food chemistry. 2023 Jun; 71(23):9080-9096. doi: 10.1021/acs.jafc.3c01249. [PMID: 37253086]
  • Lixia Hou, Qiqi Wu, Xiaomin Zhu, Xiangyu Li, Xinxin Fan, Mengling Hui, Qing Ye, Guangchao Liu, Xin Liu. Transcription Factor VvDREB2A from Vitis vinifera Improves Cold Tolerance. International journal of molecular sciences. 2023 May; 24(11):. doi: 10.3390/ijms24119381. [PMID: 37298332]
  • P Lijina, B S Gnanesh Kumar. Discrimination of raffinose and planteose based on porous graphitic carbon chromatography in combination with mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2023 May; 1224(?):123758. doi: 10.1016/j.jchromb.2023.123758. [PMID: 37245448]
  • Elisa Driesen, Wouter Saeys, Maurice De Proft, Arthur Lauwers, Wim Van den Ende. Far-Red Light Mediated Carbohydrate Concentration Changes in Leaves of Sweet Basil, a Stachyose Translocating Plant. International journal of molecular sciences. 2023 May; 24(9):. doi: 10.3390/ijms24098378. [PMID: 37176086]
  • Paras Sharma, Giridhar Goudar, Anil Kumar Chandragiri, R Ananthan, K Subhash, Anitha Chauhan, T Longvah, Mohar Singh, Rakesh Bhardwaj, Swarup Kumar Parida, Amit Kumar Singh, Gayacharan, Debasis Chattopadhyay. Assessment of diversity in anti-nutrient profile, resistant starch, minerals and carbohydrate components in different ricebean (Vigna umbellata) accessions. Food chemistry. 2023 Mar; 405(Pt A):134835. doi: 10.1016/j.foodchem.2022.134835. [PMID: 36356361]
  • Dawei Zhu, Yafang Shao, Changyun Fang, Min Li, Yonghong Yu, Yebo Qin. Effect of storage time on chemical compositions, physiological and cooking quality characteristics of different rice types. Journal of the science of food and agriculture. 2023 Mar; 103(4):2077-2087. doi: 10.1002/jsfa.12275. [PMID: 36239993]
  • Freeha Kanwal, Dingxin Ren, Wajiha Kanwal, Mengying Ding, Junqing Su, Xiaoya Shang. The potential role of non-digestible Raffinose family oligosaccharides as prebiotics. Glycobiology. 2023 Feb; ?(?):. doi: 10.1093/glycob/cwad015. [PMID: 36795047]
  • Phimonphan Chuankhayan, Ruey Hua Lee, Hong Hsiang Guan, Chein Chih Lin, Nai Chi Chen, Yen Chieh Huang, Masato Yoshimura, Atsushi Nakagawa, Chun Jung Chen. Structural insight into the hydrolase and synthase activities of an alkaline α-galactosidase from Arabidopsis from complexes with substrate/product. Acta crystallographica. Section D, Structural biology. 2023 Feb; 79(Pt 2):154-167. doi: 10.1107/s2059798323000037. [PMID: 36762861]
  • Ying Liu, Tao Li, Chunxia Zhang, Wenli Zhang, Nan Deng, Lynnette M A Dirk, A Bruce Downie, Tianyong Zhao. Raffinose positively regulates maize drought tolerance by reducing leaf transpiration. The Plant journal : for cell and molecular biology. 2023 Jan; ?(?):. doi: 10.1111/tpj.16116. [PMID: 36703577]
  • Rajarshi Sanyal, Bhubaneswar Pradhan, Danish Md Jawed, Kishor U Tribhuvan, Anil Dahuja, Madan Kumar, Narendra Kumar, Gyan P Mishra, Chet Ram, Mahesh Kumar Mahatma, Binay K Singh, Satendra K Mangrauthia, Anil K Singh, T R Sharma, Arunava Pattanayak, Sujit K Bishi. Spatio-temporal expression pattern of Raffinose Synthase genes determine the levels of Raffinose Family Oligosaccharides in peanut (Arachis hypogaea L.) seed. Scientific reports. 2023 Jan; 13(1):795. doi: 10.1038/s41598-023-27890-z. [PMID: 36646750]
  • Tao Wang, Yiqing Wang, Jiamin Zhao, Jiumei Kong, Lingzhi Zhang, Siyu Qi, Jiajia Chen, Zhidan Chen, Wen Zeng, Weijiang Sun. Identification, Characterization and Expression Profiling of the RS Gene Family during the Withering Process of White Tea in the Tea Plant (Camellia sinensis) Reveal the Transcriptional Regulation of CsRS8. International journal of molecular sciences. 2022 Dec; 24(1):. doi: 10.3390/ijms24010202. [PMID: 36613645]
  • Prafull Salvi, Vishal Varshney, Manoj Majee. Raffinose family oligosaccharides (RFOs): role in seed vigor and longevity. Bioscience reports. 2022 10; 42(10):. doi: 10.1042/bsr20220198. [PMID: 36149314]
  • Alan Gasiński, Joanna Kawa-Rygielska, Dawid Mikulski, Grzegorz Kłosowski. Changes in the raffinose family oligosaccharides content in the lentil and common bean seeds during malting and mashing processes. Scientific reports. 2022 10; 12(1):17911. doi: 10.1038/s41598-022-22943-1. [PMID: 36289395]
  • Zhen Li, Qiang Huang, Yu Zheng, Yong Zhang, Xin Li, Shiqing Zhong, Zhijiang Zeng. Identification of the Toxic Compounds in Camellia oleifera Honey and Pollen to Honey Bees (Apis mellifera). Journal of agricultural and food chemistry. 2022 Oct; 70(41):13176-13185. doi: 10.1021/acs.jafc.2c04950. [PMID: 36214176]
  • Huilin Zhang, Zheng Sun, Shan Feng, Junwei Zhang, Fan Zhang, Wenen Wang, Huirong Hu, Wei Zhang, Manzhu Bao. The C2H2-type zinc finger protein PhZFP1 regulates cold stress tolerance by modulating galactinol synthesis in Petunia hybrida. Journal of experimental botany. 2022 10; 73(18):6434-6448. doi: 10.1093/jxb/erac274. [PMID: 35726094]
  • Tomasz Kopczewski, Elżbieta Kuźniak, Iwona Ciereszko, Andrzej Kornaś. Alterations in Primary Carbon Metabolism in Cucumber Infected with Pseudomonas syringae pv lachrymans: Local and Systemic Responses. International journal of molecular sciences. 2022 Oct; 23(20):. doi: 10.3390/ijms232012418. [PMID: 36293272]
  • Grant A Hedblom, Kamal Dev, Steven D Bowden, David J Baumler. Comparative genome analysis of commensal segmented filamentous bacteria (SFB) from turkey and murine hosts reveals distinct metabolic features. BMC genomics. 2022 Sep; 23(1):659. doi: 10.1186/s12864-022-08886-x. [PMID: 36115942]
  • Jun Yang, Chengcheng Ling, Yunyan Liu, Huamin Zhang, Quaid Hussain, Shiheng Lyu, Songhu Wang, Yongsheng Liu. Genome-Wide Expression Profiling Analysis of Kiwifruit GolS and RFS Genes and Identification of AcRFS4 Function in Raffinose Accumulation. International journal of molecular sciences. 2022 Aug; 23(16):. doi: 10.3390/ijms23168836. [PMID: 36012101]
  • Momoko Ishida, Rika Ohara, Fuka Miyagawa, Hiroe Kikuzaki, Kosuke Nishi, Hiroyuki Onda, Nanami Yoshino, Takuya Sugahara. Umbelliferose Isolated from Cuminum cyminum L. Seeds Inhibits Antigen-Induced Degranulation in Rat Basophilic Leukemia RBL-2H3 Cells. Molecules (Basel, Switzerland). 2022 Jun; 27(13):. doi: 10.3390/molecules27134101. [PMID: 35807345]
  • Kenta Maegawa, Haruka Koyama, Satoru Fukiya, Atsushi Yokota, Koichiro Ueda, Satoshi Ishizuka. Dietary raffinose ameliorates hepatic lipid accumulation induced by cholic acid via modulation of enterohepatic bile acid circulation in rats. The British journal of nutrition. 2022 06; 127(11):1621-1630. doi: 10.1017/s0007114521002610. [PMID: 34256877]
  • Avery Powell, Stacy L Wilder, Alexandra B Housh, Stephanie Scott, Mary Benoit, Garren Powell, Spenser Waller, James M Guthrie, Michael J Schueller, Richard A Ferrieri. Examining effects of rhizobacteria in relieving abiotic crop stresses using carbon-11 radiotracing. Physiologia plantarum. 2022 Mar; 174(2):e13675. doi: 10.1111/ppl.13675. [PMID: 35316539]
  • Smriti Juriasingani, Vicky Vo, Masoud Akbari, Jaskiran Grewal, Max Zhang, Jifu Jiang, Aaron Haig, Alp Sener. Supplemental hydrogen sulfide in models of renal transplantation after cardiac death. Canadian journal of surgery. Journal canadien de chirurgie. 2022 Mar; 65(2):E193-E202. doi: 10.1503/cjs.013920. [PMID: 35292525]
  • Lesław Bernard Lahuta, Joanna Szablińska-Piernik, Marcin Horbowicz. Changes in Metabolic Profiles of Pea (Pisum sativum L.) as a Result of Repeated Short-Term Soil Drought and Subsequent Re-Watering. International journal of molecular sciences. 2022 Feb; 23(3):. doi: 10.3390/ijms23031704. [PMID: 35163626]
  • Cristina P S Martins, Denise Fernandes, Valéria M Guimarães, Dongliang Du, Delmira C Silva, Alex-Alan F Almeida, Frederick G Gmitter, Wagner C Otoni, Marcio G C Costa. Comprehensive analysis of the GALACTINOL SYNTHASE (GolS) gene family in citrus and the function of CsGolS6 in stress tolerance. PloS one. 2022; 17(9):e0274791. doi: 10.1371/journal.pone.0274791. [PMID: 36112700]
  • Max Y Zhang, George J Dugbartey, Smriti Juriasingani, Masoud Akbari, Winnie Liu, Aaron Haig, Patrick McLeod, Jacqueline Arp, Alp Sener. Sodium thiosulfate-supplemented UW solution protects renal grafts against prolonged cold ischemia-reperfusion injury in a murine model of syngeneic kidney transplantation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jan; 145(?):112435. doi: 10.1016/j.biopha.2021.112435. [PMID: 34798469]
  • Bing Hua, Mengying Zhang, Jinji Zhang, Haibo Dai, Zhiping Zhang, Minmin Miao. CsAGA1 and CsAGA2 Mediate RFO Hydrolysis in Partially Distinct Manner in Cucumber Fruits. International journal of molecular sciences. 2021 Dec; 22(24):. doi: 10.3390/ijms222413285. [PMID: 34948084]
  • Wassem B Naguib, Pandurang R Divte, Amaresh Chandra, Lekshmy Sathee, Bhupinder Singh, Pranab Kumar Mandal, Anjali Anand. Raffinose accumulation and preferential allocation of carbon (14 C) to developing leaves impart salinity tolerance in sugar beet. Physiologia plantarum. 2021 Dec; 173(4):1421-1433. doi: 10.1111/ppl.13420. [PMID: 33837561]
  • Qiguo Sun, Risheng Huang, Haifeng Zhu, Yanmei Sun, Zhenfei Guo. A novel Medicago truncatula calmodulin-like protein (MtCML42) regulates cold tolerance and flowering time. The Plant journal : for cell and molecular biology. 2021 11; 108(4):1069-1082. doi: 10.1111/tpj.15494. [PMID: 34528312]
  • Madiha Khan, Jianbing Hu, Bachar Dahro, Ruhong Ming, Yang Zhang, Yue Wang, Ahmed Alhag, Chunlong Li, Ji-Hong Liu. ERF108 from Poncirus trifoliata (L.) Raf. functions in cold tolerance by modulating raffinose synthesis through transcriptional regulation of PtrRafS. The Plant journal : for cell and molecular biology. 2021 11; 108(3):705-724. doi: 10.1111/tpj.15465. [PMID: 34398993]
  • Udhaya Kannan, Roopam Sharma, Manu P Gangola, Seedhabadee Ganeshan, Monica Båga, Ravindra N Chibbar. Sequential expression of raffinose synthase and stachyose synthase corresponds to successive accumulation of raffinose, stachyose and verbascose in developing seeds of Lens culinaris Medik. Journal of plant physiology. 2021 Oct; 265(?):153494. doi: 10.1016/j.jplph.2021.153494. [PMID: 34454370]
  • Sascha Grzella, Jannik Hinzmann, Nina Pillokeit, Thorsten Lengenfeld, Hans-Martin Vaihinger, Panagiota Zgoura, Timm H Westhoff, Richard Viebahn, Peter Schenker. Impact of Histidine-Tryptophan-Ketoglutarate Versus University of Wisconsin Solution on the Outcome of Pancreas Transplant With Cold Ischemic Time ≥12 Hours: A Retrospective Study. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation. 2021 08; 19(8):842-848. doi: 10.6002/ect.2020.0544. [PMID: 34142940]
  • Torsten R Goesch, Nancy A Wilson, Weifeng Zeng, Bret M Verhoven, Weixiong Zhong, Maya M Coumbe Gitter, William E Fahl. Suppression of Inflammation-Associated Kidney Damage Post-Transplant Using the New PrC-210 Free Radical Scavenger in Rats. Biomolecules. 2021 07; 11(7):. doi: 10.3390/biom11071054. [PMID: 34356678]
  • Ruifeng Cui, Xiaoge Wang, Waqar Afzal Malik, Xuke Lu, Xiugui Chen, Delong Wang, Junjuan Wang, Shuai Wang, Chao Chen, Lixue Guo, Quanjia Chen, Wuwei Ye. Genome-wide identification and expression analysis of Raffinose synthetase family in cotton. BMC bioinformatics. 2021 Jun; 22(1):356. doi: 10.1186/s12859-021-04276-4. [PMID: 34187353]
  • Hiroki Takeuchi, Mikiko Nishioka, Tadashi Maezawa, Yuko Kitano, Kento Terada-Yoshikawa, Ryota Tachibana, Manabu Kato, Suong-Hyu Hyon, Yuki Gen, Kayo Tanaka, Kuniaki Toriyabe, Masafumi Nii, Eiji Kondo, Tomoaki Ikeda. Carboxylated Poly-l-Lysine as a Macromolecular Cryoprotective Agent Enables the Development of Defined and Xeno-Free Human Sperm Cryopreservation Reagents. Cells. 2021 06; 10(6):. doi: 10.3390/cells10061435. [PMID: 34201225]
  • José R C Ferreira-Neto, Manassés D da Silva, Fabiana A Rodrigues, Alexandre L Nepomuceno, Valesca Pandolfi, David A de Lima Morais, Ederson A Kido, Ana M Benko-Iseppon. Importance of inositols and their derivatives in cowpea under root dehydration: An omics perspective. Physiologia plantarum. 2021 Jun; 172(2):441-462. doi: 10.1111/ppl.13292. [PMID: 33247842]
  • Shadan Li, Zhongli Huang, Xiaowei Li, Youguang Zhao, Xin Jiang, Yang Wen, Hao Luo, Liang Wang, Qiunong Guan, Irina Cafeeva, Donald E Brooks, Christopher Y C Nguan, Jayachandran N Kizhakkedathu, Caigan Du. Evaluation of hyperbranched polyglycerol for cold perfusion and storage of donor kidneys in a pig model of kidney autotransplantation. Journal of biomedical materials research. Part B, Applied biomaterials. 2021 06; 109(6):853-863. doi: 10.1002/jbm.b.34750. [PMID: 33098184]
  • Thomas Minor, Charlotte von Horn. Reduction of Renal Preservation/Reperfusion Injury by Controlled Hyperthermia During Ex Vivo Machine Perfusion. Clinical and translational science. 2021 03; 14(2):544-549. doi: 10.1111/cts.12906. [PMID: 33108687]
  • Julie De Beule, Steffen Fieuws, Diethard Monbaliu, Maarten Naesens, Mauricio Sainz-Barriga, Ben Sprangers, Dirk Kuypers, Jacques Pirenne, Ina Jochmans. The effect of IGL-1 preservation solution on outcome after kidney transplantation: A retrospective single-center analysis. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2021 02; 21(2):830-837. doi: 10.1111/ajt.16302. [PMID: 32888364]
  • Han-Shin Kim, Yongsun Jang, So-Young Ham, Jeong-Hoon Park, Hyun-Jin Kang, Eun Tae Yun, Dong-Hyup Shin, Kyoung-Chul Kim, Hee-Deung Park. Effect of broad-spectrum biofilm inhibitor raffinose, a plant galactoside, on the inhibition of co-culture biofilm on the microfiltration membrane. Journal of hazardous materials. 2021 01; 402(?):123501. doi: 10.1016/j.jhazmat.2020.123501. [PMID: 32712354]
  • Sebastien Giraud, Thomas Kerforne, Jeremy Zely, Virginie Ameteau, Pierre Couturier, Michel Tauc, Thierry Hauet. The inhibition of eIF5A hypusination by GC7, a preconditioning protocol to prevent brain death-induced renal injuries in a preclinical porcine kidney transplantation model. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2020 12; 20(12):3326-3340. doi: 10.1111/ajt.15994. [PMID: 32400964]
  • Camille Legeai, Louise Durand, Emilie Savoye, Marie-Alice Macher, Olivier Bastien. Effect of preservation solutions for static cold storage on kidney transplantation outcomes: A National Registry Study. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2020 12; 20(12):3426-3442. doi: 10.1111/ajt.15995. [PMID: 32400921]
  • Romina I Minen, María P Martinez, Alberto A Iglesias, Carlos M Figueroa. Biochemical characterization of recombinant UDP-sugar pyrophosphorylase and galactinol synthase from Brachypodium distachyon. Plant physiology and biochemistry : PPB. 2020 Oct; 155(?):780-788. doi: 10.1016/j.plaphy.2020.08.030. [PMID: 32866791]
  • Christina C Vinson, Ana P Z Mota, Brenda N Porto, Thais N Oliveira, Iracyara Sampaio, Ana L Lacerda, Etienne G J Danchin, Patricia M Guimaraes, Thomas C R Williams, Ana C M Brasileiro. Characterization of raffinose metabolism genes uncovers a wild Arachis galactinol synthase conferring tolerance to abiotic stresses. Scientific reports. 2020 09; 10(1):15258. doi: 10.1038/s41598-020-72191-4. [PMID: 32943670]
  • Rex Arunraj, Logan Skori, Abhinandan Kumar, Neil M N Hickerson, Naskar Shoma, Vairamani M, Marcus A Samuel. Spatial regulation of alpha-galactosidase activity and its influence on raffinose family oligosaccharides during seed maturation and germination in Cicer arietinum. Plant signaling & behavior. 2020 08; 15(8):1709707. doi: 10.1080/15592324.2019.1709707. [PMID: 31906799]
  • Kyonoshin Maruyama, Kaoru Urano, Miyako Kusano, Tetsuya Sakurai, Hironori Takasaki, Miho Kishimoto, Kyouko Yoshiwara, Makoto Kobayashi, Mikiko Kojima, Hitoshi Sakakibara, Kazuki Saito, Kazuo Shinozaki. Metabolite/phytohormone-gene regulatory networks in soybean organs under dehydration conditions revealed by integration analysis. The Plant journal : for cell and molecular biology. 2020 07; 103(1):197-211. doi: 10.1111/tpj.14719. [PMID: 32072682]
  • Tao Li, Yumin Zhang, Ying Liu, Xudong Li, Guanglong Hao, Qinghui Han, Lynnette M A Dirk, A Bruce Downie, Yong-Ling Ruan, Jianmin Wang, Guoying Wang, Tianyong Zhao. Raffinose synthase enhances drought tolerance through raffinose synthesis or galactinol hydrolysis in maize and Arabidopsis plants. The Journal of biological chemistry. 2020 06; 295(23):8064-8077. doi: 10.1074/jbc.ra120.013948. [PMID: 32366461]
  • Hongrui Wang, Joshua J Blakeslee, Michelle L Jones, Laura J Chapin, Imed E Dami. Exogenous abscisic acid enhances physiological, metabolic, and transcriptional cold acclimation responses in greenhouse-grown grapevines. Plant science : an international journal of experimental plant biology. 2020 Apr; 293(?):110437. doi: 10.1016/j.plantsci.2020.110437. [PMID: 32081274]
  • Niroshan Siva, Pushparajah Thavarajah, Dil Thavarajah. Prebiotic carbohydrate concentrations of common bean and chickpea change during cooking, cooling, and reheating. Journal of food science. 2020 Apr; 85(4):980-988. doi: 10.1111/1750-3841.15066. [PMID: 32180222]
  • Elena Collado, Tâmmila Venzke Klug, Ginés Benito Martínez-Hernández, Francisco Artés-Hernández, Ascensión Martínez-Sánchez, Encarna Aguayo, Francisco Artés, Juan A Fernández, Perla A Gómez. UV-C pretreatment of fresh-cut faba beans (Vicia faba) for shelf life extension: Effects of domestic microwaving for consumption. Food science and technology international = Ciencia y tecnologia de los alimentos internacional. 2020 Mar; 26(2):140-150. doi: 10.1177/1082013219873227. [PMID: 31544525]
  • Qinghui Han, Junlong Qi, Guanglong Hao, Chunxia Zhang, Chunmei Wang, Lynnette M A Dirk, A Bruce Downie, Tianyong Zhao. ZmDREB1A Regulates RAFFINOSE SYNTHASE Controlling Raffinose Accumulation and Plant Chilling Stress Tolerance in Maize. Plant & cell physiology. 2020 Feb; 61(2):331-341. doi: 10.1093/pcp/pcz200. [PMID: 31638155]
  • Jing Fan, Jie Liu, Zhi-You Gong, Pei-Zhou Xu, Xiao-Hong Hu, Jin-Long Wu, Guo-Bang Li, Juan Yang, Yu-Qiu Wang, Yu-Feng Zhou, Shuang-Cheng Li, Li Wang, Xiao-Qiong Chen, Min He, Ji-Qun Zhao, Yan Li, Yan-Yan Huang, Dong-Wei Hu, Xian-Jun Wu, Ping Li, Wen-Ming Wang. The false smut pathogen Ustilaginoidea virens requires rice stamens for false smut ball formation. Environmental microbiology. 2020 02; 22(2):646-659. doi: 10.1111/1462-2920.14881. [PMID: 31797523]
  • Jinji Zhang, Hao Gu, Haibo Dai, Zhiping Zhang, Minmin Miao. Alternative polyadenylation of the stacyose synthase gene mediates source-sink regulation in cucumber. Journal of plant physiology. 2020 Feb; 245(?):153111. doi: 10.1016/j.jplph.2019.153111. [PMID: 31926460]
  • Li Hua Cui, Mi Young Byun, Hyeong Geun Oh, Sung Jin Kim, Jungeun Lee, Hyun Park, Hyoungseok Lee, Woo Taek Kim. Poaceae Type II Galactinol Synthase 2 from Antarctic Flowering Plant Deschampsia antarctica and Rice Improves Cold and Drought Tolerance by Accumulation of Raffinose Family Oligosaccharides in Transgenic Rice Plants. Plant & cell physiology. 2020 Jan; 61(1):88-104. doi: 10.1093/pcp/pcz180. [PMID: 31513272]
  • Rima Thapa, Militza Carrero-Colón, Katy M Rainey, Karen Hudson. TILLING by Sequencing: A Successful Approach to Identify Rare Alleles in Soybean Populations. Genes. 2019 12; 10(12):. doi: 10.3390/genes10121003. [PMID: 31817015]
  • Rune Nørgaard Rasmussen, Kenneth Vielsted Christensen, René Holm, Carsten Uhd Nielsen. Transcriptome analysis identifies activated signaling pathways and regulated ABC transporters and solute carriers after hyperosmotic stress in renal MDCK I cells. Genomics. 2019 12; 111(6):1557-1565. doi: 10.1016/j.ygeno.2018.10.014. [PMID: 30389539]
  • Vitalii Mutsenko, Ariana Barlič, Tamara Pezić, Janja Dermol-Černe, Barbara Dovgan, Bulat Sydykov, Willem F Wolkers, Igor I Katkov, Birgit Glasmacher, Damijan Miklavčič, Oleksandr Gryshkov. Me2SO- and serum-free cryopreservation of human umbilical cord mesenchymal stem cells using electroporation-assisted delivery of sugars. Cryobiology. 2019 12; 91(?):104-114. doi: 10.1016/j.cryobiol.2019.10.002. [PMID: 31593692]
  • Joanne K Hobbs, Edward P W Meier, Benjamin Pluvinage, Mackenzie A Mey, Alisdair B Boraston. Molecular analysis of an enigmatic Streptococcus pneumoniae virulence factor: The raffinose-family oligosaccharide utilization system. The Journal of biological chemistry. 2019 11; 294(46):17197-17208. doi: 10.1074/jbc.ra119.010280. [PMID: 31591266]
  • Leonie H Venema, Aukje Brat, Cyril Moers, Nils A 't Hart, Rutger J Ploeg, Patrick Hannaert, Thomas Minor, And Henri G D Leuvenink. Effects of Oxygen During Long-term Hypothermic Machine Perfusion in a Porcine Model of Kidney Donation After Circulatory Death. Transplantation. 2019 10; 103(10):2057-2064. doi: 10.1097/tp.0000000000002728. [PMID: 30951018]
  • Lei Gu, Tao Jiang, Chunxia Zhang, Xudong Li, Chunmei Wang, Yumin Zhang, Tao Li, Lynnette M A Dirk, A Bruce Downie, Tianyong Zhao. Maize HSFA2 and HSBP2 antagonistically modulate raffinose biosynthesis and heat tolerance in Arabidopsis. The Plant journal : for cell and molecular biology. 2019 10; 100(1):128-142. doi: 10.1111/tpj.14434. [PMID: 31180156]
  • Pachara Thananurak, Napapach Chuaychu-Noo, Aurore Thélie, Yupin Phasuk, Thevin Vongpralub, Elisabeth Blesbois. Sucrose increases the quality and fertilizing ability of cryopreserved chicken sperms in contrast to raffinose. Poultry science. 2019 Sep; 98(9):4161-4171. doi: 10.3382/ps/pez196. [PMID: 31065720]
  • Jan Weis, Håkan Ahlström, Olle Korsgren. Proton MR spectroscopy of human pancreas allografts. Magma (New York, N.Y.). 2019 Aug; 32(4):511-517. doi: 10.1007/s10334-019-00740-8. [PMID: 30937576]
  • Kambiz Morabbi Heravi, Hildegard Watzlawick, Josef Altenbuchner. The melREDCA Operon Encodes a Utilization System for the Raffinose Family of Oligosaccharides in Bacillus subtilis. Journal of bacteriology. 2019 08; 201(15):. doi: 10.1128/jb.00109-19. [PMID: 31138628]
  • C Consuegra, F Crespo, J Dorado, M Diaz-Jimenez, B Pereira, I Ortiz, M Hidalgo. Vitrification of stallion sperm using 0.25 ml straws: Effect of volume, concentration and carbohydrates (sucrose/trehalose/raffinose). Animal reproduction science. 2019 Jul; 206(?):69-77. doi: 10.1016/j.anireprosci.2019.05.009. [PMID: 31138492]
  • Alexsandra Pereira Rodrigues, Gustavo Araujo Pereira, Pedro Henrique Ferreira Tomé, Henrique Silvano Arruda, Marcos Nogueira Eberlin, Glaucia Maria Pastore. Chemical Composition and Antioxidant Activity of Monguba (Pachira aquatica) Seeds. Food research international (Ottawa, Ont.). 2019 07; 121(?):880-887. doi: 10.1016/j.foodres.2019.01.014. [PMID: 31108821]
  • Mehmet Haberal, Mahir Kirnap, S Remzi Erdem, B Handan Ozdemir, K Michael Lux, Didem Bacanli. Evaluation of New Baskent University Preservation Solution for Kidney Graft During Cold Ischemia: Preliminary Experimental Animal Study. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation. 2019 06; 17(3):287-297. doi: 10.6002/ect.bups2019. [PMID: 31145052]
  • Sophia Goßner, Fengjie Yuan, Chenguang Zhou, Yuanyuan Tan, Qingyao Shu, Karl-Heinz Engel. Stability of the Metabolite Signature Resulting from the MIPS1 Mutation in Low Phytic Acid Soybean ( Glycine max L. Merr.) Mutants upon Cross-Breeding. Journal of agricultural and food chemistry. 2019 May; 67(17):5043-5052. doi: 10.1021/acs.jafc.9b00817. [PMID: 30977368]
  • Sherif Khedr, Oleg Palygin, Tengis S Pavlov, Gregory Blass, Vladislav Levchenko, Ammar Alsheikh, Michael W Brands, Ashraf El-Meanawy, Alexander Staruschenko. Increased ENaC activity during kidney preservation in Wisconsin solution. BMC nephrology. 2019 04; 20(1):145. doi: 10.1186/s12882-019-1329-7. [PMID: 31035971]
  • Yumin Zhang, Qichao Sun, Chunxia Zhang, Guanglong Hao, Chunmei Wang, Lynnette M A Dirk, A Bruce Downie, Tianyong Zhao. Maize VIVIPAROUS1 Interacts with ABA INSENSITIVE5 to Regulate GALACTINOL SYNTHASE2 Expression Controlling Seed Raffinose Accumulation. Journal of agricultural and food chemistry. 2019 Apr; 67(15):4214-4223. doi: 10.1021/acs.jafc.9b00322. [PMID: 30915847]
  • Y-F Chen, X Yang, H-J Yang. Heterologous Antibodies Adsorption in Xenotransplantation of a Landrace Piglet Kidney Into a Rhesus Monkey. Transplantation proceedings. 2019 Apr; 51(3):987-992. doi: 10.1016/j.transproceed.2019.01.032. [PMID: 30979492]
  • Yujuan Zhang, Donghua Li, Rong Zhou, Xiao Wang, Komivi Dossa, Linhai Wang, Yanxin Zhang, Jingyin Yu, Huihui Gong, Xiurong Zhang, Jun You. Transcriptome and metabolome analyses of two contrasting sesame genotypes reveal the crucial biological pathways involved in rapid adaptive response to salt stress. BMC plant biology. 2019 Feb; 19(1):66. doi: 10.1186/s12870-019-1665-6. [PMID: 30744558]
  • Keiichi Uto, Seisuke Sakamoto, Weitao Que, Keita Shimata, Shintaro Hashimoto, Masataka Sakisaka, Yasuko Narita, Daiki Yoshii, Lin Zhong, Yoshihiro Komohara, Xiao-Kang Li, Yukihiro Inomata, Taizo Hibi. Hydrogen-rich solution attenuates cold ischemia-reperfusion injury in rat liver transplantation. BMC gastroenterology. 2019 Feb; 19(1):25. doi: 10.1186/s12876-019-0939-7. [PMID: 30736744]
  • Charlotte von Horn, Patrick Hannaert, Thierry Hauet, Henri Leuvenink, Andreas Paul, Thomas Minor. Cold flush after dynamic liver preservation protects against ischemic changes upon reperfusion - an experimental study. Transplant international : official journal of the European Society for Organ Transplantation. 2019 02; 32(2):218-224. doi: 10.1111/tri.13354. [PMID: 30251360]
  • Chaoyu Tian, Jiangang Yang, Yan Zeng, Tong Zhang, Yingbiao Zhou, Yan Men, Chun You, Yueming Zhu, Yuanxia Sun. Biosynthesis of Raffinose and Stachyose from Sucrose via an In Vitro Multienzyme System. Applied and environmental microbiology. 2019 01; 85(2):. doi: 10.1128/aem.02306-18. [PMID: 30389762]
  • Smriti Juriasingani, Masoud Akbari, Justin Yh Chan, Matthew Whiteman, Alp Sener. H2S supplementation: A novel method for successful organ preservation at subnormothermic temperatures. Nitric oxide : biology and chemistry. 2018 12; 81(?):57-66. doi: 10.1016/j.niox.2018.10.004. [PMID: 30393129]
  • T Ćelić, H Omrčen, J Španjol, D Bobinac. Mechanisms of Bone Morphogenetic Protein-7 Protective Effects Against Cold Ischemia-Induced Renal Injury in Rats. Transplantation proceedings. 2018 Dec; 50(10):3822-3830. doi: 10.1016/j.transproceed.2018.08.035. [PMID: 30577274]
  • Bingyong Mao, Hongyu Tang, Jiayu Gu, Dongyao Li, Shumao Cui, Jianxin Zhao, Hao Zhang, Wei Chen. In vitro fermentation of raffinose by the human gut bacteria. Food & function. 2018 Nov; 9(11):5824-5831. doi: 10.1039/c8fo01687a. [PMID: 30357216]
  • Onur Kirtel, Carmen Menéndez, Maxime Versluys, Wim Van den Ende, Lázaro Hernández, Ebru Toksoy Öner. Levansucrase from Halomonas smyrnensis AAD6T: first halophilic GH-J clan enzyme recombinantly expressed, purified, and characterized. Applied microbiology and biotechnology. 2018 Nov; 102(21):9207-9220. doi: 10.1007/s00253-018-9311-z. [PMID: 30120521]
  • Yin Jing, Sirui Lang, Dongmei Wang, Hua Xue, Xiao-Feng Wang. Functional characterization of galactinol synthase and raffinose synthase in desiccation tolerance acquisition in developing Arabidopsis seeds. Journal of plant physiology. 2018 Nov; 230(?):109-121. doi: 10.1016/j.jplph.2018.10.011. [PMID: 30368031]
  • Begoña García-Cenador, Víctor Blanco-Gozalo, Daniel López-Montañés, Juan R Sanz Giménez-Rico, José M López-Novoa, Francisco J López-Hernández. Cardiotrophin-1 Improves Kidney Preservation, Graft Function, and Survival in Transplanted Rats. Transplantation. 2018 10; 102(10):e404-e412. doi: 10.1097/tp.0000000000002313. [PMID: 30247450]
  • Kaarel Adamberg, Signe Adamberg, Karin Ernits, Anneli Larionova, Tiia Voor, Madis Jaagura, Triinu Visnapuu, Tiina Alamäe. Composition and metabolism of fecal microbiota from normal and overweight children are differentially affected by melibiose, raffinose and raffinose-derived fructans. Anaerobe. 2018 Aug; 52(?):100-110. doi: 10.1016/j.anaerobe.2018.06.009. [PMID: 29935270]
  • Devindra Shakappa, Aruna Talari, Hemalatha Rajkumar, Mohammed Shujauddin. Hypolipidemic Effect of Red Gram (Cajanus cajan L.) Prebiotic Oligosaccharides in Wistar NIN Rats. Journal of dietary supplements. 2018 Jul; 15(4):410-418. doi: 10.1080/19390211.2017.1350246. [PMID: 28837379]
  • Rabindra N Bhattacharjee, Mahms Richard-Mohamed, Qizhi Sun, Aaron Haig, Ghaleb Aboalsamh, Peter Barrett, Richard Mayer, Ibrahim Alhasan, Karen Pineda-Solis, Larry Jiang, Hajed Alharbi, Manujendra Saha, Eric Patterson, Alp Sener, Gediminas Cepinskas, Anthony M Jevnikar, Patrick P W Luke. CORM-401 Reduces Ischemia Reperfusion Injury in an Ex Vivo Renal Porcine Model of the Donation After Circulatory Death. Transplantation. 2018 07; 102(7):1066-1074. doi: 10.1097/tp.0000000000002201. [PMID: 29677080]
  • Gaowa Bai, Takeshi Tsuruta, Naoki Nishino. Dietary soy, meat, and fish proteins modulate the effects of prebiotic raffinose on composition and fermentation of gut microbiota in rats. International journal of food sciences and nutrition. 2018 Jun; 69(4):480-487. doi: 10.1080/09637486.2017.1382454. [PMID: 28958174]
  • Joris Meurs, Morgan R Alexander, Pavel A Levkin, Simon Widmaier, Josephine Bunch, David A Barrett, Dong-Hyun Kim. Improved Extraction Repeatability and Spectral Reproducibility for Liquid Extraction Surface Analysis-Mass Spectrometry Using Superhydrophobic-Superhydrophilic Patterning. Analytical chemistry. 2018 05; 90(10):6001-6005. doi: 10.1021/acs.analchem.8b00973. [PMID: 29701986]
  • Hao Gu, Man Lu, Zhiping Zhang, Jinjin Xu, Wenhua Cao, Minmin Miao. Metabolic process of raffinose family oligosaccharides during cold stress and recovery in cucumber leaves. Journal of plant physiology. 2018 May; 224-225(?):112-120. doi: 10.1016/j.jplph.2018.03.012. [PMID: 29617631]
  • Qingwei Zhang, Xiaomin Song, Dorothea Bartels. Sugar metabolism in the desiccation tolerant grass Oropetium thomaeum in response to environmental stresses. Plant science : an international journal of experimental plant biology. 2018 May; 270(?):30-36. doi: 10.1016/j.plantsci.2018.02.004. [PMID: 29576083]
  • Padmanaban Muthukumaran, Gopal Thiyagarajan, Rajendran Arun Babu, Baddireddi Subhadra Lakshmi. Raffinose from Costus speciosus attenuates lipid synthesis through modulation of PPARs/SREBP1c and improves insulin sensitivity through PI3K/AKT. Chemico-biological interactions. 2018 Mar; 284(?):80-89. doi: 10.1016/j.cbi.2018.02.011. [PMID: 29458019]
  • Xiaoming Sun, José Tomás Matus, Darren Chern Jan Wong, Zemin Wang, Fengmei Chai, Langlang Zhang, Ting Fang, Li Zhao, Yi Wang, Yuepeng Han, Qingfeng Wang, Shaohua Li, Zhenchang Liang, Haiping Xin. The GARP/MYB-related grape transcription factor AQUILO improves cold tolerance and promotes the accumulation of raffinose family oligosaccharides. Journal of experimental botany. 2018 03; 69(7):1749-1764. doi: 10.1093/jxb/ery020. [PMID: 29385617]
  • Jun You, Yanyan Wang, Yujuan Zhang, Komivi Dossa, Donghua Li, Rong Zhou, Linhai Wang, Xiurong Zhang. Genome-wide identification and expression analyses of genes involved in raffinose accumulation in sesame. Scientific reports. 2018 03; 8(1):4331. doi: 10.1038/s41598-018-22585-2. [PMID: 29531231]
  • Lei Wang, Jin Wei, Shan Jiang, Hui-Hua Li, Liying Fu, Jie Zhang, Ruisheng Liu. Effects of different storage solutions on renal ischemia tolerance after kidney transplantation in mice. American journal of physiology. Renal physiology. 2018 03; 314(3):F381-F387. doi: 10.1152/ajprenal.00475.2017. [PMID: 29141940]