Cyperquat (BioDeep_00000008596)
代谢物信息卡片
1-Methyl-4-phenylpyridinium
化学式: C12H12N+ (170.097)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C[N+]1=CC=C(C=C1)C2=CC=CC=C2
InChI: InChI=1S/C12H12N/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11/h2-10H,1H3/q+1
描述信息
D010575 - Pesticides > D006540 - Herbicides
D016573 - Agrochemicals
同义名列表
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:173662
- ChEBI: CHEBI:641
- KEGG: C11310
- PubChem: 39484
- ChEMBL: CHEMBL311617
- MeSH: 1-Methyl-4-phenylpyridinium
- CAS: 48134-75-4
- PMhub: MS000022227
- PubChem: 13485
- PDB-CCD: WRF
- NIKKAJI: J21.572D
- KNApSAcK: 173662
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yonghui Wang, Zhuo Li, Jiwen Li, Chao Sun. LncRNA NEAT1 promotes MPP+ induced injury of PC12 cells and accelerates the progression of Parkinson's disease in mice through FUS mediated inhibition of PI3K/AKT/mTOR signalling pathway.
Experimental gerontology.
2024 Jun; 191(?):112436. doi:
10.1016/j.exger.2024.112436. [PMID: 38636570] - Jiahua Huang, Xinyue Zhang, Xueping Yang, Qingyun Yv, Fanlong Ye, Sheng Chen, Ying Cui, Linting Gu, Min Zhu, Wenwei Li. Baicalin exerts neuroprotective actions by regulating the Nrf2-NLRP3 axis in toxin-induced models of Parkinson's disease.
Chemico-biological interactions.
2024 Jan; 387(?):110820. doi:
10.1016/j.cbi.2023.110820. [PMID: 38016618] - Wenbo Fan, Jianwu Zhou. Icariside II suppresses ferroptosis to protect against MPP+-Induced Parkinson's disease through Keap1/Nrf2/GPX4 signaling.
The Chinese journal of physiology.
2023 Nov; 66(6):437-445. doi:
10.4103/cjop.cjop-d-23-00107. [PMID: 38149556] - Yanyan Jiang, Guangming Xie, Aydos Alimujiang, Hongrong Xie, Weiting Yang, Feng Yin, Dongya Huang. Protective Effects of Querectin against MPP+-Induced Dopaminergic Neurons Injury via the Nrf2 Signaling Pathway.
Frontiers in bioscience (Landmark edition).
2023 03; 28(3):42. doi:
10.31083/j.fbl2803042. [PMID: 37005755] - Belinda Fouché, Stephanie Turner, Rebecca Gorham, Eloise J Stephenson, Simon Gutbier, Joanna L Elson, Olimpo García-Beltrán, Francois H Van Der Westhuizen, Ilse S Pienaar. A Novel Mitochondria-Targeting Iron Chelator Neuroprotects Multimodally via HIF-1 Modulation Against a Mitochondrial Toxin in a Dopaminergic Cell Model of Parkinson's Disease.
Molecular neurobiology.
2023 Feb; 60(2):749-767. doi:
10.1007/s12035-022-03107-8. [PMID: 36357615] - M E Arslan, A Yılmaz. Neuroprotective effects of Geranium Robertianum L. Aqueous extract on the cellular Parkinson's disease model.
European review for medical and pharmacological sciences.
2023 01; 27(2):570-579. doi:
10.26355/eurrev_202301_31058. [PMID: 36734700] - Li-Kung Wu, Surbhi Agarwal, Chia-Hua Kuo, Yen-Lun Kung, Cecilia Hsuan Day, Pi-Yu Lin, Shinn-Zong Lin, Dennis Jine-Yuan Hsieh, Chih-Yang Huang, Chien-Yi Chiang. Artemisia Leaf Extract protects against neuron toxicity by TRPML1 activation and promoting autophagy/mitophagy clearance in both in vitro and in vivo models of MPP+/MPTP-induced Parkinson's disease.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Sep; 104(?):154250. doi:
10.1016/j.phymed.2022.154250. [PMID: 35752074] - Jianhu Fan, Dahua Wu, Yuxing Guo, Zhongbao Yang. SOS1-IT1 silencing alleviates MPP+-induced neuronal cell injury through regulating the miR-124-3p/PTEN/AKT/mTOR pathway.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia.
2022 May; 99(?):137-146. doi:
10.1016/j.jocn.2022.01.003. [PMID: 35279586] - Zhijiang Zhuang, Lihong Zhang, Chongchong Liu. SNHG14 Upregulation Was a Molecular Mechanism Underlying MPP+ Neurotoxicity in Dopaminergic SK-N-SH Cells via SNHG14-miR-519a-3p-ATG10 ceRNA Pathway.
Neurotoxicity research.
2022 Apr; 40(2):553-563. doi:
10.1007/s12640-022-00488-5. [PMID: 35349097] - Lina Li, Hongjuan Wang, Huicang Li, Xin Lu, Yanxiang Gao, Xiaofeng Guo. Long noncoding RNA BACE1-antisense transcript plays a critical role in Parkinson's disease via microRNA-214-3p/Cell death-inducing p53-target protein 1 axis.
Bioengineered.
2022 04; 13(4):10889-10901. doi:
10.1080/21655979.2022.2066750. [PMID: 35481549] - Qingxin Song, Shanxin Peng, Xiaosong Zhu. Baicalein protects against MPP+/MPTP-induced neurotoxicity by ameliorating oxidative stress in SH-SY5Y cells and mouse model of Parkinson's disease.
Neurotoxicology.
2021 12; 87(?):188-194. doi:
10.1016/j.neuro.2021.10.003. [PMID: 34666128] - Hongyan Yang, Libo Li, Yu Jiao, Yuanliang Zhang, Yuhua Wang, Kunjie Zhu, Chao Sun. Thioredoxin-1 mediates neuroprotection of Schisanhenol against MPP+-induced apoptosis via suppression of ASK1-P38-NF-κB pathway in SH-SY5Y cells.
Scientific reports.
2021 11; 11(1):21604. doi:
10.1038/s41598-021-01000-3. [PMID: 34732784] - Gabriela Pérez-Barrón, Sergio Montes, Yoshajandith Aguirre-Vidal, Marti Santiago, Elena Gallardo, José Luis Espartero, Camilo Ríos, Antonio Monroy-Noyola. Antioxidant Effect of Hydroxytyrosol, Hydroxytyrosol Acetate and Nitrohydroxytyrosol in a Rat MPP+ Model of Parkinson's Disease.
Neurochemical research.
2021 Nov; 46(11):2923-2935. doi:
10.1007/s11064-021-03379-x. [PMID: 34260002] - Qi Xu, Ziyu Chen, Borong Zhu, Yiming Li, Manju B Reddy, Huilin Liu, Guodong Dang, Qi Jia, Xiaojun Wu. Neuroprotective Effects of B-Type Cinnamon Procyanidin Oligomers on MPP+-Induced Apoptosis in a Cell Culture Model of Parkinson's Disease.
Molecules (Basel, Switzerland).
2021 Oct; 26(21):. doi:
10.3390/molecules26216422. [PMID: 34770830] - Adaze Bijou Enogieru, William Haylett, Donavon Hiss, Okobi Ekpo. Inhibition of γH2AX, COX-2 and regulation of antioxidant enzymes in MPP+-exposed SH-SY5Y cells pre-treated with rutin.
Metabolic brain disease.
2021 10; 36(7):2119-2130. doi:
10.1007/s11011-021-00746-z. [PMID: 33978902] - B S Cagle, M L Sturgeon, J B O'Brien, J C Wilkinson, R A Cornell, D L Roman, J A Doorn. Stable expression of the human dopamine transporter in N27 cells as an in vitro model for dopamine cell trafficking and metabolism.
Toxicology in vitro : an international journal published in association with BIBRA.
2021 Oct; 76(?):105210. doi:
10.1016/j.tiv.2021.105210. [PMID: 34252731] - Jie Cao, Baojian Guo, Sai Li, Xaojing Zhang, Xiaoqi Zhang, Gaoxiao Zhang, Yewei Sun, Yuqiang Wang, Xiubao Song, Zaijun Zhang. Neuroprotection against 1-Methyl-4-phenylpyridinium-induced cytotoxicity by naturally occurring polydatin through activation of transcription factor MEF2D.
Neuroreport.
2021 08; 32(12):1065-1072. doi:
10.1097/wnr.0000000000001696. [PMID: 34232128] - Liping Bai, Fang Yan, Ruhua Deng, Rou Gu, Xianwen Zhang, Jie Bai. Thioredoxin-1 Rescues MPP+/MPTP-Induced Ferroptosis by Increasing Glutathione Peroxidase 4.
Molecular neurobiology.
2021 Jul; 58(7):3187-3197. doi:
10.1007/s12035-021-02320-1. [PMID: 33634378] - Ratchaneekorn Reudhabibadh, Thunwa Binlateh, Pennapa Chonpathompikunlert, Nongyao Nonpanya, Peerada Prommeenate, Pithi Chanvorachote, Pilaiwanwadee Hutamekalin. Suppressing Cdk5 Activity by Luteolin Inhibits MPP+-Induced Apoptotic of Neuroblastoma through Erk/Drp1 and Fak/Akt/GSK3β Pathways.
Molecules (Basel, Switzerland).
2021 Feb; 26(5):. doi:
10.3390/molecules26051307. [PMID: 33671094] - Gaurav Bhatia, Jatinder Singh, Bimla Nehru. Neuroprotective effects of hydro-alcoholic extract of Eclipta alba against 1-methyl-4-phenylpyridinium-induced in vitro and in vivo models of Parkinson's disease.
Environmental science and pollution research international.
2021 Feb; 28(8):9390-9406. doi:
10.1007/s11356-020-11452-1. [PMID: 33145730] - Dajing Jiang, Yang Peng. The protective effect of decoction of Rehmanniae via PI3K/Akt/mTOR pathway in MPP+-induced Parkinson's disease model cells.
Journal of receptor and signal transduction research.
2021 Feb; 41(1):74-84. doi:
10.1080/10799893.2020.1787445. [PMID: 32611232] - Asami Saito, Naoki Ishiguro, Masahito Takatani, Bojan Bister, Hiroyuki Kusuhara. Impact of Direction of Transport on the Evaluation of Inhibition Potencies of Multidrug and Toxin Extrusion Protein 1 Inhibitors.
Drug metabolism and disposition: the biological fate of chemicals.
2021 02; 49(2):152-158. doi:
10.1124/dmd.120.000136. [PMID: 33262224] - Xu Li, Tian-Jiao Xu, Li-Kun Liu, Miao-Xian Dong. [Antioxidant mechanism of gastrodin combined with isorhynchophylline in inhibiting MPP~+-induced apoptosis of PC12 cells].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2021 Jan; 46(2):420-425. doi:
10.19540/j.cnki.cjcmm.20201009.401. [PMID: 33645131] - Juliann D Jaumotte, Mart Saarma, Michael J Zigmond. Protection of dopamine neurons by CDNF and neurturin variant N4 against MPP+ in dissociated cultures from rat mesencephalon.
PloS one.
2021; 16(2):e0245663. doi:
10.1371/journal.pone.0245663. [PMID: 33534843] - Yoshajandith Aguirre-Vidal, Jorge Morales-Montor, Carmen T Gómez de León, Pedro Ostoa-Saloma, Mariana Díaz-Zaragoza, Sergio Montes, Marcela Arteaga-Silva, Antonio Monroy-Noyola. Protection induced by estradiol benzoate in the MPP+ rat model of Parkinson's disease is associated with the regulation of the inflammatory cytokine profile in the nigro striatum.
Journal of neuroimmunology.
2020 12; 349(?):577426. doi:
10.1016/j.jneuroim.2020.577426. [PMID: 33096292] - Fang Zhang, Xia Zhang, Sheng Guo, Funing Cao, Xiaofei Zhang, Yaqi Wang, Jiazheng Liu, Bowen Qian, Yichao Yan, Peidong Chen, Chunlei Xu, Chunmei Liu, Dawei Qian, Jin-Ao Duan. An acidic heteropolysaccharide from Lycii fructus: Purification, characterization, neurotrophic and neuroprotective activities in vitro.
Carbohydrate polymers.
2020 Dec; 249(?):116894. doi:
10.1016/j.carbpol.2020.116894. [PMID: 32933702] - Abobaker S Ibrakaw, Sylvester I Omoruyi, Okobi E Ekpo, Ahmed A Hussein. Neuroprotective Activities of Boophone haemanthoides (Amaryllidaceae) Extract and Its Chemical Constituents.
Molecules (Basel, Switzerland).
2020 Nov; 25(22):. doi:
10.3390/molecules25225376. [PMID: 33212961] - Xiaoli Chang, Zegang Ma, Limin Shi, Junxia Xie. Effects of ghrelin on the electrical activities of substantia nigra dopaminergic neurons treated with MPP.
Neurochemistry international.
2020 09; 138(?):104780. doi:
10.1016/j.neuint.2020.104780. [PMID: 32569790] - Im-Sook Song, Hyeon-Uk Jeong, Min-Koo Choi, Mihwa Kwon, Yongho Shin, Jeong Han Kim, Hye-Suk Lee. Interactions between cyazofamid and human drug transporters.
Journal of biochemical and molecular toxicology.
2020 Apr; 34(4):e22459. doi:
10.1002/jbt.22459. [PMID: 32003934] - Tanapol Limboonreung, Patoomratana Tuchinda, Sukumal Chongthammakun. Chrysoeriol mediates mitochondrial protection via PI3K/Akt pathway in MPP+ treated SH-SY5Y cells.
Neuroscience letters.
2020 01; 714(?):134545. doi:
10.1016/j.neulet.2019.134545. [PMID: 31622648] - Severin Hörmann, Zhibo Gai, Gerd A Kullak-Ublick, Michele Visentin. Plasma Membrane Cholesterol Regulates the Allosteric Binding of 1-Methyl-4-Phenylpyridinium to Organic Cation Transporter 2 (SLC22A2).
The Journal of pharmacology and experimental therapeutics.
2020 01; 372(1):46-53. doi:
10.1124/jpet.119.260877. [PMID: 31624079] - Adaze Bijou Enogieru, William Lloyd Haylett, Hayley Christy Miller, Francois Hendrikus van der Westhuizen, Donavon Charles Hiss, Okobi Eko Ekpo. Attenuation of Endoplasmic Reticulum Stress, Impaired Calcium Homeostasis, and Altered Bioenergetic Functions in MPP+-Exposed SH-SY5Y Cells Pretreated with Rutin.
Neurotoxicity research.
2019 Nov; 36(4):764-776. doi:
10.1007/s12640-019-00048-4. [PMID: 31055769] - Jian-Liang Zhu, Yu-Ying Wu, Di Wu, Wei-Feng Luo, Zhi-Qing Zhang, Chun-Feng Liu. SC79, a novel Akt activator, protects dopaminergic neuronal cells from MPP+ and rotenone.
Molecular and cellular biochemistry.
2019 Nov; 461(1-2):81-89. doi:
10.1007/s11010-019-03592-x. [PMID: 31342299] - Kuan-Ho Lin, Chien-Yu Li, Yuan-Man Hsu, Chang-Hai Tsai, Fuu-Jen Tsai, Chih-Hsin Tang, Jai-Sing Yang, Zhi-Hong Wang, Mei-Chin Yin. Oridonin, A natural diterpenoid, protected NGF-differentiated PC12 cells against MPP+- and kainic acid-induced injury.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2019 Nov; 133(?):110765. doi:
10.1016/j.fct.2019.110765. [PMID: 31430510] - Liyue Qin, Ziyu Chen, Liu Yang, Hailian Shi, Hui Wu, Beibei Zhang, Weiqi Zhang, Qi Xu, Fei Huang, Xiaojun Wu. Luteolin-7-O-glucoside protects dopaminergic neurons by activating estrogen-receptor-mediated signaling pathway in MPTP-induced mice.
Toxicology.
2019 10; 426(?):152256. doi:
10.1016/j.tox.2019.152256. [PMID: 31381935] - Wassamon Boonying, Alvin Joselin, En Huang, Dianbo Qu, Farzaneh Safarpour, Grace O Iyirhiaro, Yasmilde Rodriguez Gonzalez, Steve M Callaghan, Ruth S Slack, Daniel Figeys, Young-Hwa Chung, David S Park. Pink1 regulates FKBP5 interaction with AKT/PHLPP and protects neurons from neurotoxin stress induced by MPP.
Journal of neurochemistry.
2019 08; 150(3):312-329. doi:
10.1111/jnc.14683. [PMID: 30734931] - Yu-Fei Xi, Si-Fan Liu, Wei Hong, Xiao-Yu Song, Li-Li Lou, Le Zhou, Guo-Dong Yao, Bin Lin, Xiao-Bo Wang, Xiao-Xiao Huang, Shao-Jiang Song. Discovery of cycloneolignan enantiomers from Isatis indigotica Fortune with neuroprotective effects against MPP+-induced SH-SY5Y cell injury.
Bioorganic chemistry.
2019 07; 88(?):102926. doi:
10.1016/j.bioorg.2019.102926. [PMID: 31005021] - Bryan Lickteig, Virangika K Wimalasena, Kandatege Wimalasena. N-Methyl-4-phenylpyridinium Scaffold-Containing Lipophilic Compounds Are Potent Complex I Inhibitors and Selective Dopaminergic Toxins.
ACS chemical neuroscience.
2019 06; 10(6):2977-2988. doi:
10.1021/acschemneuro.9b00184. [PMID: 30929447] - Jong Cheol Lee, Joon Seon Yang, Myeong Hee Moon. Simultaneous Relative Quantification of Various Polyglycerophospholipids with Isotope-Labeled Methylation by Nanoflow Ultrahigh Performance Liquid Chromatography-Tandem Mass Spectrometry.
Analytical chemistry.
2019 05; 91(10):6716-6723. doi:
10.1021/acs.analchem.9b00800. [PMID: 31008580] - Jiang Chang, Xiao-Le Zhang, Hua Yu, Jie Chen. Downregulation of RTN1-C attenuates MPP+-induced neuronal injury through inhibition of mGluR5 pathway in SN4741 cells.
Brain research bulletin.
2019 03; 146(?):1-6. doi:
10.1016/j.brainresbull.2018.11.026. [PMID: 30521940] - Thorsten Keller, Valentin Gorboulev, Thomas D Mueller, Volker Dötsch, Frank Bernhard, Hermann Koepsell. Rat Organic Cation Transporter 1 Contains Three Binding Sites for Substrate 1-Methyl-4-phenylpyridinium per Monomer.
Molecular pharmacology.
2019 02; 95(2):169-182. doi:
10.1124/mol.118.113498. [PMID: 30409791] - Shaheen Jafri Ali, Govindraj Ellur, Md Touseef Khan, Kunal Sharan. Bone loss in MPTP mouse model of Parkinson's disease is triggered by decreased osteoblastogenesis and increased osteoclastogenesis.
Toxicology and applied pharmacology.
2019 01; 363(?):154-163. doi:
10.1016/j.taap.2018.12.003. [PMID: 30529163] - Simon Gutbier, Patrick May, Sylvie Berthelot, Abhimanyu Krishna, Timo Trefzer, Mehri Behbehani, Liudmila Efremova, Johannes Delp, Gerhard Gstraunthaler, Tanja Waldmann, Marcel Leist. Major changes of cell function and toxicant sensitivity in cultured cells undergoing mild, quasi-natural genetic drift.
Archives of toxicology.
2018 12; 92(12):3487-3503. doi:
10.1007/s00204-018-2326-5. [PMID: 30298209] - Shelby L Johnson, Hyun Y Park, Nicholas A DaSilva, Dhiraj A Vattem, Hang Ma, Navindra P Seeram. Levodopa-Reduced Mucuna pruriens Seed Extract Shows Neuroprotective Effects against Parkinson's Disease in Murine Microglia and Human Neuroblastoma Cells, Caenorhabditis elegans, and Drosophila melanogaster.
Nutrients.
2018 Aug; 10(9):. doi:
10.3390/nu10091139. [PMID: 30131460] - Chuwen Li, Benqin Tang, Yu Feng, Fan Tang, Maggie Pui-Man Hoi, Ziren Su, Simon Ming-Yuen Lee. Pinostrobin Exerts Neuroprotective Actions in Neurotoxin-Induced Parkinson's Disease Models through Nrf2 Induction.
Journal of agricultural and food chemistry.
2018 Aug; 66(31):8307-8318. doi:
10.1021/acs.jafc.8b02607. [PMID: 29961319] - Julian Maier, Felix P Mayer, Dino Luethi, Marion Holy, Kathrin Jäntsch, Harald Reither, Lena Hirtler, Marius C Hoener, Matthias E Liechti, Christian Pifl, Simon D Brandt, Harald H Sitte. The psychostimulant (±)-cis-4,4'-dimethylaminorex (4,4'-DMAR) interacts with human plasmalemmal and vesicular monoamine transporters.
Neuropharmacology.
2018 08; 138(?):282-291. doi:
10.1016/j.neuropharm.2018.06.018. [PMID: 29908239] - Valentin Gorboulev, Saba Rehman, Christoph M Albert, Ursula Roth, Marleen J Meyer, Mladen V Tzvetkov, Thomas D Mueller, Hermann Koepsell. Assay Conditions Influence Affinities of Rat Organic Cation Transporter 1: Analysis of Mutagenesis in the Modeled Outward-Facing Cleft by Measuring Effects of Substrates and Inhibitors on Initial Uptake.
Molecular pharmacology.
2018 04; 93(4):402-415. doi:
10.1124/mol.117.110767. [PMID: 29339398] - Vandita Singh, Musthafa Mohamed Essa, Nejib Guizani, Rengasamy Balakrishnan, Tamiloli Hemalatha, Thamilarasan Manivasagam, Arokiasamy Justin-Thenmozhi, Namasivayam Elangovan, Thirunavukkarasu Velusamy. Protective effect of Zizyphus spinachristi on MPP+-induced oxidative stress.
Frontiers in bioscience (Scholar edition).
2018 03; 10(2):285-299. doi:
10.2741/s516. [PMID: 29293433] - Yi-Nan Zhang, Yan-Fang Yang, Xiu-Wei Yang. Blood-brain barrier permeability and neuroprotective effects of three main alkaloids from the fruits of Euodia rutaecarpa with MDCK-pHaMDR cell monolayer and PC12 cell line.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Feb; 98(?):82-87. doi:
10.1016/j.biopha.2017.12.017. [PMID: 29245070] - Qiuling Sang, Xiaoyang Liu, Libo Wang, Ling Qi, Wenping Sun, Weiyao Wang, Yajuan Sun, Haina Zhang. Curcumin Protects an SH-SY5Y Cell Model of Parkinson's Disease Against Toxic Injury by Regulating HSP90.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018; 51(2):681-691. doi:
10.1159/000495326. [PMID: 30463061] - Se-Myeong Cheon, Insoo Jang, Myon-Hee Lee, Dae Keun Kim, Hoon Jeon, Dong Seok Cha. Sorbus alnifolia protects dopaminergic neurodegeneration in Caenorhabditis elegans.
Pharmaceutical biology.
2017 Dec; 55(1):481-486. doi:
10.1080/13880209.2016.1251468. [PMID: 27937005] - Predrag Kalaba, Nilima Y Aher, Marija Ilić, Vladimir Dragačević, Marcus Wieder, Andras G Miklosi, Martin Zehl, Judith Wackerlig, Alexander Roller, Tetyana Beryozkina, Bojana Radoman, Sivaprakasam R Saroja, Wolfgang Lindner, Eduardo Perez Gonzalez, Vasiliy Bakulev, Johann Jakob Leban, Harald H Sitte, Ernst Urban, Thierry Langer, Gert Lubec. Heterocyclic Analogues of Modafinil as Novel, Atypical Dopamine Transporter Inhibitors.
Journal of medicinal chemistry.
2017 11; 60(22):9330-9348. doi:
10.1021/acs.jmedchem.7b01313. [PMID: 29091428] - Sungwoo Hyung, Wonji Pyeon, Ji Eun Park, Yoo-Kyung Song, Suk-Jae Chung. The conditional stimulation of rat organic cation transporter 2, but not its human ortholog, by mesoridazine: the possibility of the involvement of the high-affinity binding site of the transporter in the stimulation.
The Journal of pharmacy and pharmacology.
2017 Nov; 69(11):1513-1523. doi:
10.1111/jphp.12799. [PMID: 28809437] - Yoshajandith Aguirre-Vidal, Antonio Monroy-Noyola, Laura Anaya-Ramos, Marcela Arteaga-Silva, Marisela Mendez-Armenta, Pedro Ostoa-Saloma, Mariana Díaz-Zaragoza, Jorge Morales-Montor, Camilo Ríos, Sergio Montes. β-Estradiol-3-benzoate confers neuroprotection in Parkinson MPP+ rat model through inhibition of lipid peroxidation.
Steroids.
2017 10; 126(?):7-14. doi:
10.1016/j.steroids.2017.08.001. [PMID: 28827046] - Yoshiyuki Kubo, Masakazu Yamamoto, Kensuke Matsunaga, Takuya Usui, Shin-Ichi Akanuma, Ken-Ichi Hosoya. Retina-to-Blood Transport of 1-Methyl-4-Phenylpyridinium Involves Carrier-Mediated Process at the Blood-Retinal Barrier.
Journal of pharmaceutical sciences.
2017 09; 106(9):2583-2591. doi:
10.1016/j.xphs.2017.04.028. [PMID: 28454745] - Takuya Matsumoto, Yui Ishizaki, Keika Mochizuki, Mitsuru Aoyagi, Yoshiharu Mitoma, Shoichiro Ishizaki, Yuji Nagashima. Urinary Excretion of Tetrodotoxin Modeled in a Porcine Renal Proximal Tubule Epithelial Cell Line, LLC-PK₁.
Marine drugs.
2017 Jul; 15(7):. doi:
10.3390/md15070225. [PMID: 28714912] - Qin Cao, Liyue Qin, Fei Huang, Xiaoshuang Wang, Liu Yang, Hailian Shi, Hui Wu, Beibei Zhang, Ziyu Chen, Xiaojun Wu. Amentoflavone protects dopaminergic neurons in MPTP-induced Parkinson's disease model mice through PI3K/Akt and ERK signaling pathways.
Toxicology and applied pharmacology.
2017 03; 319(?):80-90. doi:
10.1016/j.taap.2017.01.019. [PMID: 28185818] - Chiung-Mei Chen, I-Cheng Chen, Ying-Lin Chen, Te-Hsien Lin, Wan-Ling Chen, Chih-Ying Chao, Yih-Ru Wu, Yeah-Ting Lu, Cheng-Yu Lee, Hong-Chi Chien, Ting-Shou Chen, Guey-Jen Lee-Chen, Chi-Mei Lee. Medicinal herbs Oenanthe javanica (Blume) DC., Casuarina equisetifolia L. and Sorghum bicolor (L.) Moench protect human cells from MPP+ damage via inducing FBXO7 expression.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2016 Nov; 23(12):1422-1433. doi:
10.1016/j.phymed.2016.08.004. [PMID: 27765362] - J Wang. The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition.
Clinical pharmacology and therapeutics.
2016 Nov; 100(5):489-499. doi:
10.1002/cpt.442. [PMID: 27506881] - Fan Xiao, Ping Zhang, Ai-Hua Chen, Chun-Yan Wang, Wei Zou, Hong-Feng Gu, Xiao-Qing Tang. Hydrogen sulfide inhibits MPP+-induced aldehyde stress and endoplasmic reticulum stress in PC12 cells: involving upregulation of BDNF.
Experimental cell research.
2016 Oct; 348(1):106-114. doi:
10.1016/j.yexcr.2016.09.006. [PMID: 27641114] - Andrea Hubeny, Markus Keiser, Stefan Oswald, Gabriele Jedlitschky, Heyo K Kroemer, Werner Siegmund, Markus Grube. Expression of Organic Anion Transporting Polypeptide 1A2 in Red Blood Cells and Its Potential Impact on Antimalarial Therapy.
Drug metabolism and disposition: the biological fate of chemicals.
2016 10; 44(10):1562-8. doi:
10.1124/dmd.116.069807. [PMID: 27504015] - Qing Zhao, Xiaoyan Yang, Dingfang Cai, Ling Ye, Yuqing Hou, Lijun Zhang, Jiwei Cheng, Yuan Shen, Kaizhe Wang, Yu Bai. Echinacoside Protects Against MPP(+)-Induced Neuronal Apoptosis via ROS/ATF3/CHOP Pathway Regulation.
Neuroscience bulletin.
2016 Aug; 32(4):349-62. doi:
10.1007/s12264-016-0047-4. [PMID: 27432061] - Wendy Lee, James J Crawford, Ignacio Aliagas, Lesley J Murray, Suzanne Tay, Weiru Wang, Christopher E Heise, Klaus P Hoeflich, Hank La, Simon Mathieu, Robert Mintzer, Sreemathy Ramaswamy, Lionel Rouge, Joachim Rudolph. Synthesis and evaluation of a series of 4-azaindole-containing p21-activated kinase-1 inhibitors.
Bioorganic & medicinal chemistry letters.
2016 08; 26(15):3518-24. doi:
10.1016/j.bmcl.2016.06.031. [PMID: 27346791] - Yi Zhang, Xiao-Gang Gong, Zhen-Zhen Wang, Hong-Mei Sun, Zhen-Yu Guo, Cong Gai, Jing-Hong Hu, Ling Ma, Ping Li, Nai-Hong Chen. Protective effects of DJ-1 medicated Akt phosphorylation on mitochondrial function are promoted by Da-Bu-Yin-Wan in 1-methyl-4-phenylpyridinium-treated human neuroblastoma SH-SY5Y cells.
Journal of ethnopharmacology.
2016 Jul; 187(?):83-93. doi:
10.1016/j.jep.2016.04.029. [PMID: 27114059] - Song Yu, Xu Wang, Xingliang He, Yue Wang, Sujie Gao, Lu Ren, Yan Shi. Curcumin exerts anti-inflammatory and antioxidative properties in 1-methyl-4-phenylpyridinium ion (MPP(+))-stimulated mesencephalic astrocytes by interference with TLR4 and downstream signaling pathway.
Cell stress & chaperones.
2016 07; 21(4):697-705. doi:
10.1007/s12192-016-0695-3. [PMID: 27164829] - Thomas M Jeitner, Mike Kalogiannis, Boris F Krasnikov, Irving Gomolin, Morgan R Peltier, Graham R Moran. Linking Inflammation and Parkinson Disease: Hypochlorous Acid Generates Parkinsonian Poisons.
Toxicological sciences : an official journal of the Society of Toxicology.
2016 06; 151(2):388-402. doi:
10.1093/toxsci/kfw052. [PMID: 27026709] - Manuela Meireles, Eduardo Moura, Maria Augusta Vieira-Coelho, Celestino Santos-Buelga, Susana Gonzalez-Manzano, Montserrat Dueñas, Nuno Mateus, Ana Faria, Conceição Calhau. Flavonoids as dopaminergic neuromodulators.
Molecular nutrition & food research.
2016 Mar; 60(3):495-501. doi:
10.1002/mnfr.201500557. [PMID: 26582321] - Su-Yan Dong, Yan-Jie Guo, Ya Feng, Xin-Xin Cui, Sheng-Han Kuo, Te Liu, Yun-Cheng Wu. The epigenetic regulation of HIF-1α by SIRT1 in MPP(+) treated SH-SY5Y cells.
Biochemical and biophysical research communications.
2016 Feb; 470(2):453-459. doi:
10.1016/j.bbrc.2016.01.013. [PMID: 26768367] - L J Martínez-Guerrero, K K Evans, W H Dantzler, S H Wright. The multidrug transporter MATE1 sequesters OCs within an intracellular compartment that has no influence on OC secretion in renal proximal tubules.
American journal of physiology. Renal physiology.
2016 Jan; 310(1):F57-67. doi:
10.1152/ajprenal.00318.2015. [PMID: 26538438] - Liping Li, Siyuan Sun, Yayun Weng, Feifeng Song, Sisi Zhou, Mengru Bai, Hui Zhou, Su Zeng, Huidi Jiang. Interaction of six protoberberine alkaloids with human organic cation transporters 1, 2 and 3.
Xenobiotica; the fate of foreign compounds in biological systems.
2016; 46(2):175-83. doi:
10.3109/00498254.2015.1056283. [PMID: 26134304] - Mona Bains, James L Roberts. Estrogen protects against dopamine neuron toxicity in primary mesencephalic cultures through an indirect P13K/Akt mediated astrocyte pathway.
Neuroscience letters.
2016 Jan; 610(?):79-85. doi:
10.1016/j.neulet.2015.10.054. [PMID: 26520464] - Li Jinfeng, Wang Yunliang, Liu Xinshan, Wang Yutong, Wang Shanshan, Xue Peng, Yang Xiaopeng, Xu Zhixiu, Lu Qingshan, Yin Honglei, Cao Xia, Wang Hongwei, Cao Bingzhen. Therapeutic Effects of CUR-Activated Human Umbilical Cord Mesenchymal Stem Cells on 1-Methyl-4-phenylpyridine-Induced Parkinson's Disease Cell Model.
BioMed research international.
2016; 2016(?):9140541. doi:
10.1155/2016/9140541. [PMID: 27340670] - Kai Liu, Huamin Xu, Hengwei Xiang, Peng Sun, Junxia Xie. Protective effects of Ndfip1 on MPP(+)-induced apoptosis in MES23.5 cells and its underlying mechanisms.
Experimental neurology.
2015 Nov; 273(?):215-24. doi:
10.1016/j.expneurol.2015.08.013. [PMID: 26300475] - Yunlong Zhang, Xiuping Zhang, Shaogang Qu. Ceftriaxone Protects Astrocytes from MPP(+) via Suppression of NF-κB/JNK/c-Jun Signaling.
Molecular neurobiology.
2015 Aug; 52(1):78-92. doi:
10.1007/s12035-014-8845-z. [PMID: 25112679] - Yang Liu, Ren-Yu Zhang, Jun Zhao, Zheng Dong, Dong-Yun Feng, Rui Wu, Ming Shi, Gang Zhao. Ginsenoside Rd Protects SH-SY5Y Cells against 1-Methyl-4-phenylpyridinium Induced Injury.
International journal of molecular sciences.
2015 Jun; 16(7):14395-408. doi:
10.3390/ijms160714395. [PMID: 26114390] - Richard B Rothman, Subramaniam Ananthan, John S Partilla, Surendra K Saini, Omar Moukha-Chafiq, Vibha Pathak, Michael H Baumann. Studies of the biogenic amine transporters 15. Identification of novel allosteric dopamine transporter ligands with nanomolar potency.
The Journal of pharmacology and experimental therapeutics.
2015 Jun; 353(3):529-38. doi:
10.1124/jpet.114.222299. [PMID: 25788711] - Hong Guo, Fang Shi, Meijiao Li, Qingqing Liu, Bin Yu, Limin Hu. Neuroprotective effects of Eucommia ulmoides Oliv. and its bioactive constituent work via ameliorating the ubiquitin-proteasome system.
BMC complementary and alternative medicine.
2015 May; 15(?):151. doi:
10.1186/s12906-015-0675-7. [PMID: 25994206] - Yoshajandith Aguirre-Vidal, Sergio Montes, Luis Tristan-López, Laura Anaya-Ramos, John Teiber, Camilo Ríos, Verónica Baron-Flores, Antonio Monroy-Noyola. The neuroprotective effect of lovastatin on MPP(+)-induced neurotoxicity is not mediated by PON2.
Neurotoxicology.
2015 May; 48(?):166-70. doi:
10.1016/j.neuro.2015.03.012. [PMID: 25842176] - Guoqi Zhu, Junyao Li, Ling He, Xuncui Wang, Xiaoqi Hong. MPTP-induced changes in hippocampal synaptic plasticity and memory are prevented by memantine through the BDNF-TrkB pathway.
British journal of pharmacology.
2015 May; 172(9):2354-68. doi:
10.1111/bph.13061. [PMID: 25560396] - Fei Sa, Lun Qing Zhang, Cheong Meng Chong, Bao Jian Guo, Sai Li, Zai Jun Zhang, Ying Zheng, Pui Man Hoi, Simon Ming Yuen Lee. Discovery of novel anti-parkinsonian effect of schisantherin A in in vitro and in vivo.
Neuroscience letters.
2015 Apr; 593(?):7-12. doi:
10.1016/j.neulet.2015.03.016. [PMID: 25770828] - Weihai Liu, Songzhi Kong, Qingfeng Xie, Jiyan Su, Wenjie Li, Huizhen Guo, Shanshan Li, Xuexuan Feng, Ziren Su, Yang Xu, Xiaoping Lai. Protective effects of apigenin against 1-methyl-4-phenylpyridinium ion‑induced neurotoxicity in PC12 cells.
International journal of molecular medicine.
2015 Mar; 35(3):739-46. doi:
10.3892/ijmm.2014.2056. [PMID: 25573459] - Toyofumi Suzuki, Toshiro Fukami, Kazuo Tomono. Possible involvement of cationic-drug sensitive transport systems in the blood-to-brain influx and brain-to-blood efflux of amantadine across the blood-brain barrier.
Biopharmaceutics & drug disposition.
2015 Mar; 36(2):126-37. doi:
10.1002/bdd.1926. [PMID: 25410756] - Nayoung Bae, Sungkwon Chung, Hee Ju Kim, Jin Wook Cha, Hyungun Oh, Ming-Yao Gu, Myung Sook Oh, Hyun Ok Yang. Neuroprotective effect of modified Chungsimyeolda-tang, a traditional Korean herbal formula, via autophagy induction in models of Parkinson's disease.
Journal of ethnopharmacology.
2015 Jan; 159(?):93-101. doi:
10.1016/j.jep.2014.11.007. [PMID: 25449460] - Maria Bexten, Stefan Oswald, Markus Grube, Jia Jia, Tanja Graf, Uwe Zimmermann, Kathrin Rodewald, Oliver Zolk, Ulrich Schwantes, Werner Siegmund, Markus Keiser. Expression of drug transporters and drug metabolizing enzymes in the bladder urothelium in man and affinity of the bladder spasmolytic trospium chloride to transporters likely involved in its pharmacokinetics.
Molecular pharmaceutics.
2015 Jan; 12(1):171-8. doi:
10.1021/mp500532x. [PMID: 25466967] - Kristina Hacker, Renke Maas, Johannes Kornhuber, Martin F Fromm, Oliver Zolk. Substrate-Dependent Inhibition of the Human Organic Cation Transporter OCT2: A Comparison of Metformin with Experimental Substrates.
PloS one.
2015; 10(9):e0136451. doi:
10.1371/journal.pone.0136451. [PMID: 26327616] - M Rubio-Osornio, E Gorostieta-Salas, S Montes, F Pérez-Severiano, C Rubio, C Gómez, C Ríos, J Guevara. Epicatechin Reduces Striatal MPP⁺-Induced Damage in Rats through Slight Increases in SOD-Cu,Zn Activity.
Oxidative medicine and cellular longevity.
2015; 2015(?):276039. doi:
10.1155/2015/276039. [PMID: 26301040] - Kuo-Chen Wu, Ya-Hsuan Lu, Yi-Hsuan Peng, Ting-Fen Tsai, Yu-Han Kao, Hui-Ting Yang, Chun-Jung Lin. Decreased expression of organic cation transporters, Oct1 and Oct2, in brain microvessels and its implication to MPTP-induced dopaminergic toxicity in aged mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2015 Jan; 35(1):37-47. doi:
10.1038/jcbfm.2014.162. [PMID: 25248837] - Yueting Shao, Hing Man Chan. Effects of methylmercury on dopamine release in MN9D neuronal cells.
Toxicology mechanisms and methods.
2015; 25(8):637-44. doi:
10.3109/15376516.2015.1053654. [PMID: 26056851] - Andrew G Yee, Sun-Min Lee, Morag R Hunter, Michelle Glass, Peter S Freestone, Janusz Lipski. Effects of the Parkinsonian toxin MPP+ on electrophysiological properties of nigral dopaminergic neurons.
Neurotoxicology.
2014 Dec; 45(?):1-11. doi:
10.1016/j.neuro.2014.08.009. [PMID: 25193392] - M M Khan, S Zaheer, J Nehman, A Zaheer. Suppression of glia maturation factor expression prevents 1-methyl-4-phenylpyridinium (MPP⁺)-induced loss of mesencephalic dopaminergic neurons.
Neuroscience.
2014 Sep; 277(?):196-205. doi:
10.1016/j.neuroscience.2014.07.003. [PMID: 25016212] - Mohammad Moshahid Khan, Duraisamy Kempuraj, Smita Zaheer, Asgar Zaheer. Glia maturation factor deficiency suppresses 1-methyl-4-phenylpyridinium-induced oxidative stress in astrocytes.
Journal of molecular neuroscience : MN.
2014 Aug; 53(4):590-9. doi:
10.1007/s12031-013-0225-z. [PMID: 24430624] - Annett Riedel, Roman Lang, Barbara Rohm, Malte Rubach, Thomas Hofmann, Veronika Somoza. Structure-dependent effects of pyridine derivatives on mechanisms of intestinal fatty acid uptake: regulation of nicotinic acid receptor and fatty acid transporter expression.
The Journal of nutritional biochemistry.
2014 Jul; 25(7):750-7. doi:
10.1016/j.jnutbio.2014.03.002. [PMID: 24767308] - Vivian Massmann, Bayram Edemir, Eberhard Schlatter, Rouvier Al-Monajjed, Saliha Harrach, Philipp Klassen, Svenja K Holle, Aleksandra Sindic, Marina Dobrivojevic, Hermann Pavenstädt, Giuliano Ciarimboli. The organic cation transporter 3 (OCT3) as molecular target of psychotropic drugs: transport characteristics and acute regulation of cloned murine OCT3.
Pflugers Archiv : European journal of physiology.
2014 Mar; 466(3):517-27. doi:
10.1007/s00424-013-1335-8. [PMID: 23982114] - Amanda R Decker, Matthew S McNeill, Aaron M Lambert, Jeffrey D Overton, Yu-Chia Chen, Ramón A Lorca, Nicolas A Johnson, Susan E Brockerhoff, Durga P Mohapatra, Heather MacArthur, Pertti Panula, Mark A Masino, Loren W Runnels, Robert A Cornell. Abnormal differentiation of dopaminergic neurons in zebrafish trpm7 mutant larvae impairs development of the motor pattern.
Developmental biology.
2014 Feb; 386(2):428-39. doi:
10.1016/j.ydbio.2013.11.015. [PMID: 24291744] - Aderbal S Aguiar, Fabrine Sales Massafera Tristão, Majid Amar, Caroline Chevarin, Viviane Glaser, Roberta de Paula Martins, Eduardo Luiz Gasnhar Moreira, Raymond Mongeau, Laurence Lanfumey, Rita Raisman-Vozari, Alexandra Latini, Rui D S Prediger. Six weeks of voluntary exercise don't protect C57BL/6 mice against neurotoxicity of MPTP and MPP(+).
Neurotoxicity research.
2014 Feb; 25(2):147-52. doi:
10.1007/s12640-013-9412-5. [PMID: 23873578] - Adriana Alarcón-Aguilar, Viridiana Yazmín González-Puertos, Armando Luna-López, Ambar López-Macay, Julio Morán, Abel Santamaría, Mina Königsberg. Comparing the effects of two neurotoxins in cortical astrocytes obtained from rats of different ages: involvement of oxidative damage.
Journal of applied toxicology : JAT.
2014 Feb; 34(2):127-38. doi:
10.1002/jat.2841. [PMID: 23280820] - Alexander Brendel, Jana Renziehausen, Christian Behl, Parvana Hajieva. Downregulation of PMCA2 increases the vulnerability of midbrain neurons to mitochondrial complex I inhibition.
Neurotoxicology.
2014 Jan; 40(?):43-51. doi:
10.1016/j.neuro.2013.11.003. [PMID: 24269647] - Baojian Guo, Daping Xu, Hongwei Duan, Jing Du, Zaijun Zhang, Simon Mingyuen Lee, Yuqiang Wang. Therapeutic effects of multifunctional tetramethylpyrazine nitrone on models of Parkinson's disease in vitro and in vivo.
Biological & pharmaceutical bulletin.
2014; 37(2):274-85. doi:
10.1248/bpb.b13-00743. [PMID: 24305623] - Dongwei Li, Qingping Liu, Dong Jia, Deqiang Dou, Xiaofei Wang, Tingguo Kang. Protective effect of arctigenin against MPP+ and MPTP-induced neurotoxicity.
Planta medica.
2014 Jan; 80(1):48-55. doi:
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