cinaroside (BioDeep_00000859295)

Main id: BioDeep_00000000277

 

PANOMIX_OTCML-2023 Antitumor activity


代谢物信息卡片


2-(3,4-dihydroxyphenyl)-5-hydroxy-7-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]-4-chromenone

化学式: C21H20O11 (448.100557)
中文名称: 木犀草苷, 木犀草素葡萄糖甙
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=C(C=C1C2=CC(=O)C3=C(C=C(C=C3O2)OC4C(C(C(C(O4)CO)O)O)O)O)O)O
InChI: InChI=1S/C21H20O11/c22-7-16-18(27)19(28)20(29)21(32-16)30-9-4-12(25)17-13(26)6-14(31-15(17)5-9)8-1-2-10(23)11(24)3-8/h1-6,16,18-25,27-29H,7H2/t16-,18-,19+,20-,21-/m1/s1

描述信息

Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 32 nM. Cynaroside also is a promising inhibitor for H2O2-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities[1][3][4][5].

同义名列表

40 个代谢物同义名

2-(3,4-dihydroxyphenyl)-5-hydroxy-7-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]-4-chromenone; 2-(3,4-dihydroxyphenyl)-5-hydroxy-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-chromen-4-one; 2-(3,4-dihydroxyphenyl)-5-hydroxy-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxy-chromone; 2-(3,4-dihydroxyphenyl)-5-hydroxy-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-chromen-4-one; 2-(3,4-dihydroxyphenyl)-5-hydroxy-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one; 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-, mono-beta-D-glucopyranoside; 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one mono-beta-D-glucopyranoside; 4H-1-benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-7-(beta-D-glucopyranosyloxy)-5-hydroxy-; 2-(3,4-Dihydroxyphenyl)-7-(beta-D-glucopyranosyloxy)-5-hydroxy-4H-1-benzopyran-4-one; 7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(3,4-dihydroxyphenyl)-4H-chromen-4-one; 2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-yl beta-D-glucopyranoside; Flavone, 3,4,5,7-tetrahydroxy-, mono-beta-D-glucopyranoside; 7-O-beta-D-Glucosyl-5,7,3,4-tetrahydroxyflavone; Flavon, 3,4,5,7-tetrahydroxy-, glucoside; Luteolin 7-O-beta-D-glucoside; Luteolin 7-O-glucopyranoside; Luteolin 7-O-D-glucoside; Luteolin 7-monoglucoside; Luteolin 7-O-glucoside; luteolin-7-O-glucoside; Luteolin monoglucoside; luteolin-7-glucoside; Luteolin 7-glucoside; Luteolin, glucoside; 7-Glucosylluteolin; EINECS 226-365-8; NCGC00163589-01; 7-Glucoluteolin; Glucoluteolin; MEGxp0_000619; STOCK1N-08497; CHEBI:27994; luteoloside; AIDS-070478; AIDS070478; cinaroside; Cynaroside; 26811-41-6; C03951; Luteolin 7-O-β-D-glucoside



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

531 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yiwei Zhou, Yuhan Huang, Wei Ye, Zijie Chen, Zhengzhong Yuan. Cynaroside improved depressive-like behavior in CUMS mice by suppressing microglial inflammation and ferroptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Apr; 173(?):116425. doi: 10.1016/j.biopha.2024.116425. [PMID: 38490155]
  • Sahar Saleh Alghamdi, Sara Abdulaziz Alghashem, Rizwan Ali, Arwa Alsubait, Rasha Saad Suliman, Afrah E Mohammed, Zeyad Alehaideb, Raghad Abdullah Alshafi, Allulu Yousef Alturki, Ishrat Rahman. Exploring the potential of Ziziphus nummularia and luteolin-7-O-glucoside as tubulin inhibitors in cancer therapy and survival. Scientific reports. 2024 03; 14(1):7202. doi: 10.1038/s41598-024-57680-0. [PMID: 38531974]
  • Taghreed A Majrashi, Mahmoud A El Hassab, Sara H Mahmoud, Ahmed Mostafa, Engy A Wahsh, Eslam B Elkaeed, Fatma E Hassan, Wagdy M Eldehna, Shimaa M Abdelgawad. In vitro biological evaluation and in silico insights into the antiviral activity of standardized olive leaves extract against SARS-CoV-2. PloS one. 2024; 19(4):e0301086. doi: 10.1371/journal.pone.0301086. [PMID: 38662719]
  • Lucia Camelia Pirvu, Lucia Pintilie, Adrian Albulescu, Amalia Stefaniu, Georgeta Neagu. Anti-Proliferative Potential of Cynaroside and Orientin-In Silico (DYRK2) and In Vitro (U87 and Caco-2) Studies. International journal of molecular sciences. 2023 Nov; 24(23):. doi: 10.3390/ijms242316555. [PMID: 38068880]
  • Abdelhakim Bouyahya, Douae Taha, Taoufiq Benali, Gokhan Zengin, Nasreddine El Omari, Naoufal El Hachlafi, Asaad Khalid, Ashraf N Abdalla, Chrismawan Ardianto, Ching Siang Tan, Long Chiau Ming, Narjis Sahib. Natural sources, biological effects, and pharmacological properties of cynaroside. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Feb; 161(?):114337. doi: 10.1016/j.biopha.2023.114337. [PMID: 36812715]
  • Sezen Yılmaz Sarıaltın, Özlem Bahadır Acıkara. Assessment of Correlation Analysis, Phytochemical Profile, and Biological Activities of Endemic Scorzonera Species from Turkey. Chemistry & biodiversity. 2022 Oct; 19(10):e202200007. doi: 10.1002/cbdv.202200007. [PMID: 36031843]
  • Gabin Thierry M Bitchagno, Anja Schüffler, Jonathan Gross, Matthias Krumb, Pierre Tane, Till Opatz. Sesquiterpene Lactones from Vernonia tufnelliae: Structural Characterization and Biological Evaluation. Journal of natural products. 2022 07; 85(7):1681-1690. doi: 10.1021/acs.jnatprod.2c00055. [PMID: 35704432]
  • Shu-Ping Chen, Tian-Hong Hu, Qing Zhou, Tian-Peng Chen, Dong Yin, Huan He, Qing Huang, Ming He. Luteoloside protects the vascular endothelium against iron overload injury via the ROS/ADMA/DDAH II/eNOS/NO pathway. Chinese journal of natural medicines. 2022 Jan; 20(1):22-32. doi: 10.1016/s1875-5364(21)60110-3. [PMID: 35101247]
  • Aboli Girme, Prajkta Bhoj, Ganesh Saste, Sandeep Pawar, Amit Mirgal, Dipak Raut, Machindra Chavan, Lal Hingorani. Development and Validation of RP-HPLC Method for Vicenin-2, Orientin, Cynaroside, Betulinic Acid, Genistein, and Major Eight Bioactive Constituents with LC-ESI-MS/MS Profiling in Ocimum Genus. Journal of AOAC International. 2021 Dec; 104(6):1634-1651. doi: 10.1093/jaoacint/qsab067. [PMID: 33930142]
  • Juanli Ji, Zhongze Wang, Wei Sun, Zekun Li, Huarui Cai, Erhu Zhao, Hongjuan Cui. Effects of Cynaroside on Cell Proliferation, Apoptosis, Migration and Invasion though the MET/AKT/mTOR Axis in Gastric Cancer. International journal of molecular sciences. 2021 Nov; 22(22):. doi: 10.3390/ijms222212125. [PMID: 34830011]
  • Bruno César Correa Salles, Krissia Caroline Leme, Marcelo Aparecido da Silva, Cláudia Quintino da Rocha, Marcelo M P Tangerina, Wagner Vilegas, Sônia A Figueiredo, Stella Maris da Silveira Duarte, Maria Rita Rodrigues, Fernanda Borges de Araújo Paula. Protective effect of flavonoids from Passiflora edulis Sims on diabetic complications in rats. The Journal of pharmacy and pharmacology. 2021 Sep; 73(10):1361-1368. doi: 10.1093/jpp/rgab046. [PMID: 33772554]
  • Zheng Wang, Wen Chen, Yunying Li, Shuying Zhang, He Lou, Xiaoyan Lu, Xiaohui Fan. Reduning injection and its effective constituent luteoloside protect against sepsis partly via inhibition of HMGB1/TLR4/NF-κB/MAPKs signaling pathways. Journal of ethnopharmacology. 2021 Apr; 270(?):113783. doi: 10.1016/j.jep.2021.113783. [PMID: 33421596]
  • Jun Gu Kim, Jin Woo Lee, Thi Phuong Linh Le, Jae Sang Han, Yong Beom Cho, Haeun Kwon, Dongho Lee, Mi Kyeong Lee, Bang Yeon Hwang. Sesquiterpenoids from Chrysanthemum indicum with Inhibitory Effects on NO Production. Journal of natural products. 2021 03; 84(3):562-569. doi: 10.1021/acs.jnatprod.0c01121. [PMID: 33667099]
  • Alessandro De Stefano, Sabrina Caporali, Nicola Di Daniele, Valentina Rovella, Carmine Cardillo, Francesca Schinzari, Marilena Minieri, Massimo Pieri, Eleonora Candi, Sergio Bernardini, Manfredi Tesauro, Alessandro Terrinoni. Anti-Inflammatory and Proliferative Properties of Luteolin-7-O-Glucoside. International journal of molecular sciences. 2021 Jan; 22(3):. doi: 10.3390/ijms22031321. [PMID: 33525692]
  • Stefania Monari, Maura Ferri, Beatrice Montecchi, Mirko Salinitro, Annalisa Tassoni. Phytochemical characterization of raw and cooked traditionally consumed alimurgic plants. PloS one. 2021; 16(8):e0256703. doi: 10.1371/journal.pone.0256703. [PMID: 34437649]
  • Eui Jeong Nam, Gyhye Yoo, Joo Young Lee, Myungsuk Kim, Changho Jhin, Yang-Ju Son, Sun Young Kim, Sang Hoon Jung, Chu Won Nho. Glycosyl flavones from Humulus japonicus suppress MMP-1 production via decreasing oxidative stress in UVB irradiated human dermal fibroblasts. BMB reports. 2020 Jul; 53(7):379-384. doi: . [PMID: 32317077]
  • Saied Goodarzi, Mir Javad Tabatabaei, Razieh Mohammad Jafari, Farzaneh Shemirani, Saeed Tavakoli, Mansur Mofasseri, Zahra Tofighi. Cuminum cyminum fruits as source of luteolin- 7-O-glucoside, potent cytotoxic flavonoid against breast cancer cell lines. Natural product research. 2020 Jun; 34(11):1602-1606. doi: 10.1080/14786419.2018.1519824. [PMID: 30580606]
  • Faten Emad, Ali K Khalafalah, Magdi A El Sayed, Abou-Elhamd H Mohamed, Marc Stadler, Soleiman E Helaly. Three new polyacetylene glycosides (PAGs) from the aerial part of Launaea capitata (Asteraceae) with anti-biofilm activity against Staphylococcus aureus. Fitoterapia. 2020 Jun; 143(?):104548. doi: 10.1016/j.fitote.2020.104548. [PMID: 32209391]
  • Izabela Szymborska-Sandhu, Jarosław L Przybył, Olga Kosakowska, Katarzyna Bączek, Zenon Węglarz. Chemical Diversity of Bastard Balm (Melittis melisophyllum L.) as Affected by Plant Development. Molecules (Basel, Switzerland). 2020 May; 25(10):. doi: 10.3390/molecules25102421. [PMID: 32455929]
  • Bharath Kumar Velmurugan, Jen-Tsun Lin, B Mahalakshmi, Yi-Ching Chuang, Chia-Chieh Lin, Yu-Sheng Lo, Ming-Ju Hsieh, Mu-Kuan Chen. Luteolin-7-O-Glucoside Inhibits Oral Cancer Cell Migration and Invasion by Regulating Matrix Metalloproteinase-2 Expression and Extracellular Signal-Regulated Kinase Pathway. Biomolecules. 2020 03; 10(4):. doi: 10.3390/biom10040502. [PMID: 32224968]
  • Ewa Witkowska-Banaszczak, Violetta Krajka-Kuźniak, Katarzyna Papierska. The effect of luteolin 7-glucoside, apigenin 7-glucoside and Succisa pratensis extracts on NF-κB activation and α-amylase activity in HepG2 cells. Acta biochimica Polonica. 2020 Mar; 67(1):41-47. doi: 10.18388/abp.2020_2894. [PMID: 32129972]
  • Reham S Ibrahim, Asmaa Khairy, Hala H Zaatout, Hala M Hammoda, Aly M Metwally, Asmaa M Salman. Chemometric evaluation of alfalfa sprouting impact on its metabolic profile using HPTLC fingerprint-efficacy relationship analysis modelled with partial least squares regression. Journal of pharmaceutical and biomedical analysis. 2020 Feb; 179(?):112990. doi: 10.1016/j.jpba.2019.112990. [PMID: 31791836]
  • Jang Hoon Kim, Chang Hyun Jin. Inhibitory Activity of Flavonoids, Chrysoeriol and Luteolin-7-O-Glucopyranoside, on Soluble Epoxide Hydrolase from Capsicum chinense. Biomolecules. 2020 01; 10(2):. doi: 10.3390/biom10020180. [PMID: 31991570]
  • Young H Seo, Shin-Young Kang, Ji-Sun Shin, Seung M Ryu, A Y Lee, Goya Choi, Byeong C Moon, Dae-Sik Jang, Sang H Shim, Dongho Lee, Kyung-Tae Lee, Jun Lee. Chemical Constituents from the Aerial Parts of Agastache rugosa and Their Inhibitory Activities on Prostaglandin E2 Production in Lipopolysaccharide-Treated RAW 264.7 Macrophages. Journal of natural products. 2019 12; 82(12):3379-3385. doi: 10.1021/acs.jnatprod.9b00697. [PMID: 31747281]
  • Heba Abd El Hady El Gizawy, Mohammed Abdalla Hussein, Essam Abdel-Sattar. Biological activities, isolated compounds and HPLC profile of Verbascum nubicum. Pharmaceutical biology. 2019 Dec; 57(1):485-497. doi: 10.1080/13880209.2019.1643378. [PMID: 31401911]
  • Perihan Koysu, Nusret Genc, Mahfuz Elmastas, Huseyin Aksit, Ramazan Erenler. Isolation, identification of secondary metabolites from Salvia absconditiflora and evaluation of their antioxidative properties. Natural product research. 2019 Dec; 33(24):3592-3595. doi: 10.1080/14786419.2018.1488700. [PMID: 30445824]
  • Aleksandra Maria Juszczak, Marijana Zovko-Končić, Michał Tomczyk. Recent Trends in the Application of Chromatographic Techniques in the Analysis of Luteolin and Its Derivatives. Biomolecules. 2019 11; 9(11):. doi: 10.3390/biom9110731. [PMID: 31726801]
  • Liyue Qin, Ziyu Chen, Liu Yang, Hailian Shi, Hui Wu, Beibei Zhang, Weiqi Zhang, Qi Xu, Fei Huang, Xiaojun Wu. Luteolin-7-O-glucoside protects dopaminergic neurons by activating estrogen-receptor-mediated signaling pathway in MPTP-induced mice. Toxicology. 2019 10; 426(?):152256. doi: 10.1016/j.tox.2019.152256. [PMID: 31381935]
  • Hongyan Liu, Shu Zhu, Qian Liu, Yongqing Zhang. Spectrum-effect relationship study between HPLC fingerprints and antioxidant of honeysuckle extract. Biomedical chromatography : BMC. 2019 Oct; 33(10):e4583. doi: 10.1002/bmc.4583. [PMID: 31087668]
  • Antonio Lama-Muñoz, María Del Mar Contreras, Francisco Espínola, Manuel Moya, Antonia de Torres, Inmaculada Romero, Eulogio Castro. Extraction of oleuropein and luteolin-7-O-glucoside from olive leaves: Optimization of technique and operating conditions. Food chemistry. 2019 Sep; 293(?):161-168. doi: 10.1016/j.foodchem.2019.04.075. [PMID: 31151597]
  • Wenlong Li, Xu Yan, Jianchao Pan, Shaoyong Liu, Dongsheng Xue, Haibin Qu. Rapid analysis of the Tanreqing injection by near-infrared spectroscopy combined with least squares support vector machine and Gaussian process modeling techniques. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2019 Jul; 218(?):271-280. doi: 10.1016/j.saa.2019.03.110. [PMID: 31004970]
  • Bo Zhang, Tie-Gui Nan, Jie Xin, Zhi-Lai Zhan, Li-Ping Kang, Yuan Yuan, Bao-Min Wang, Lu-Qi Huang. Development of a colloidal gold-based lateral flow dipstick immunoassay for rapid detection of chlorogenic acid and luteoloside in Flos Lonicerae Japonicae. Journal of pharmaceutical and biomedical analysis. 2019 Jun; 170(?):83-88. doi: 10.1016/j.jpba.2019.03.035. [PMID: 30909057]
  • Seung Hwan Hwang, Hyun-Yong Kim, Yanymee N Guillen Quispe, Zhiqiang Wang, Guanglei Zuo, Soon Sung Lim. Aldose Reductase, Protein Glycation Inhibitory and Antioxidant of Peruvian Medicinal Plants: the Case of Tanacetum parthenium L. and Its Constituents. Molecules (Basel, Switzerland). 2019 May; 24(10):. doi: 10.3390/molecules24102010. [PMID: 31130646]
  • Tantan Wang, Bingxian Yang, Qijie Guan, Xi Chen, Zhuoheng Zhong, Wei Huang, Wei Zhu, Jingkui Tian. Transcriptional regulation of Lonicera japonica Thunb. during flower development as revealed by comprehensive analysis of transcription factors. BMC plant biology. 2019 May; 19(1):198. doi: 10.1186/s12870-019-1803-1. [PMID: 31088368]
  • Zhengyan Xia, Yiming Sun, Chengyong Cai, Yong He, Pengcheng Nie. Rapid Determination of Chlorogenic Acid, Luteoloside and 3,5-O-dicaffeoylquinic Acid in Chrysanthemum Using Near-Infrared Spectroscopy. Sensors (Basel, Switzerland). 2019 Apr; 19(9):. doi: 10.3390/s19091981. [PMID: 31035325]
  • Hee Ju Lee, Basanta Dhodary, Ju Yong Lee, Jin-Pyo An, Young-Kyoung Ryu, Kyoung-Shim Kim, Chul-Ho Lee, Won Keun Oh. Dereplication of Components Coupled with HPLC-qTOF-MS in the Active Fraction of Humulus japonicus and It's Protective Effects against Parkinson's Disease Mouse Model. Molecules (Basel, Switzerland). 2019 Apr; 24(7):. doi: 10.3390/molecules24071435. [PMID: 30979037]
  • Zhicong Wang, Rongjie Fu, Jianguo Ji, Bo Chen. [Simultaneous determination of chlorogenic acid and cynaroside contents in Lonicerae Japonica Flos by high resolution sampling two-dimensional liquid chromatography]. Se pu = Chinese journal of chromatography. 2019 Feb; 37(2):201-206. doi: 10.3724/sp.j.1123.2018.10008. [PMID: 30693729]
  • Angélica Ferraz Gomes, Maiara Prates Almeida, Mateus Freire Leite, Stefan Schwaiger, Hermann Stuppner, Maria Halabalaki, Juliano Geraldo Amaral, Jorge Mauricio David. Seasonal variation in the chemical composition of two chemotypes of Lippia alba. Food chemistry. 2019 Feb; 273(?):186-193. doi: 10.1016/j.foodchem.2017.11.089. [PMID: 30292367]
  • M Villalva, L Jaime, D Villanueva-Bermejo, B Lara, T Fornari, G Reglero, S Santoyo. Supercritical anti-solvent fractionation for improving antioxidant and anti-inflammatory activities of an Achillea millefolium L. extract. Food research international (Ottawa, Ont.). 2019 01; 115(?):128-134. doi: 10.1016/j.foodres.2018.08.027. [PMID: 30599924]
  • José Luiz Carneiro da Rocha, Danielle Figuerêdo da Silva, Anne Ramos de Santana, Diego Mota da Costa, José Floriano Barêa Pastore, Clayton Queiroz Alves, Manoelito Coelho Santos Santos Junior, Hugo Neves Brandão. Asemeia ovata (Polygalaceae): Quantitative determination and evaluation in silico of identified substances by HPLC-DAD. Computational biology and chemistry. 2018 Aug; 75(?):65-73. doi: 10.1016/j.compbiolchem.2018.04.018. [PMID: 29747077]
  • Didier Fraisse, Alexandra Degerine-Roussel, Alexis Bred, Samba Fama Ndoye, Magali Vivier, Catherine Felgines, François Senejoux. A Novel HPLC Method for Direct Detection of Nitric Oxide Scavengers from Complex Plant Matrices and Its Application to Aloysia triphylla Leaves. Molecules (Basel, Switzerland). 2018 06; 23(7):. doi: 10.3390/molecules23071574. [PMID: 29958472]
  • Yueran Zhao, Deqiang Dou, Yueqiu Guo, Yue Qi, Jun Li, Dong Jia. Comparison of the Trace Elements and Active Components of Lonicera japonica flos and Lonicera flos Using ICP-MS and HPLC-PDA. Biological trace element research. 2018 Jun; 183(2):379-388. doi: 10.1007/s12011-017-1138-4. [PMID: 28864954]
  • Sarra Kefi, Rym Essid, Khawla Mkadmini, Asma Kefi, Faouzia Mahjoub Haddada, Olfa Tabbene, Ferid Limam. Phytochemical investigation and biological activities of Echium arenarium (Guss) extracts. Microbial pathogenesis. 2018 May; 118(?):202-210. doi: 10.1016/j.micpath.2018.02.050. [PMID: 29486276]
  • Zexiong Chen, Guohua Liu, Ning Tang, Zhengguo Li. Transcriptome Analysis Reveals Molecular Signatures of Luteoloside Accumulation in Senescing Leaves of Lonicera macranthoides. International journal of molecular sciences. 2018 Mar; 19(4):. doi: 10.3390/ijms19041012. [PMID: 29597293]
  • Qing-Jun Zou, Tao Wang, Qiao-Sheng Guo, You-Mei Xiao, Li-Wei Wu. [Cloning and expression analysis of F3'H and quantification of downstream products in Chrysanthemum morifolium under flooding stress]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2018 Jan; 43(1):52-57. doi: 10.19540/j.cnki.cjcmm.20171030.008. [PMID: 29552811]
  • Menglu Zhou, Shuying Shen, Xin Zhao, Xingguo Gong. Luteoloside induces G0/G1 arrest and pro-death autophagy through the ROS-mediated AKT/mTOR/p70S6K signalling pathway in human non-small cell lung cancer cell lines. Biochemical and biophysical research communications. 2017 12; 494(1-2):263-269. doi: 10.1016/j.bbrc.2017.10.042. [PMID: 29024631]
  • Mouna Maatouk, Nadia Mustapha, Imen Mokdad-Bzeouich, Hind Chaaban, Besma Abed, Irina Iaonnou, Kamel Ghedira, Mohamed Ghoul, Leila Chekir Ghedira. Thermal treatment of luteolin-7-O-β-glucoside improves its immunomodulatory and antioxidant potencies. Cell stress & chaperones. 2017 11; 22(6):775-785. doi: 10.1007/s12192-017-0808-7. [PMID: 28578499]
  • Eirini Sarrou, Ioannis Ganopoulos, Aliki Xanthopoulou, Domenico Masuero, Stefan Martens, Panagiotis Madesis, Athanasios Mavromatis, Paschalina Chatzopoulou. Genetic diversity and metabolic profile of Salvia officinalis populations: implications for advanced breeding strategies. Planta. 2017 Aug; 246(2):201-215. doi: 10.1007/s00425-017-2666-z. [PMID: 28314999]
  • Rudi Hendra, Paul A Keller. Phytochemical Studies on Two Australian Anigozanthos Plant Species. Journal of natural products. 2017 07; 80(7):2141-2145. doi: 10.1021/acs.jnatprod.7b00063. [PMID: 28682615]
  • Juanqiang Wang, Shan Geng, Binghai Wang, Qian Shao, Yingtong Fang, Yun Wei. Magnetic nanoparticles and high-speed countercurrent chromatography coupled in-line and using the same solvent system for separation of quercetin-3-O-rutinoside, luteoloside and astragalin from a Mikania micrantha extract. Journal of chromatography. A. 2017 Jul; 1508(?):42-52. doi: 10.1016/j.chroma.2017.05.062. [PMID: 28602506]
  • Cristina Sgherri, Usue Pérez-López, Francesco Micaelli, Jon Miranda-Apodaca, Amaia Mena-Petite, Alberto Muñoz-Rueda, Mike Frank Quartacci. Elevated CO2 and salinity are responsible for phenolics-enrichment in two differently pigmented lettuces. Plant physiology and biochemistry : PPB. 2017 Jun; 115(?):269-278. doi: 10.1016/j.plaphy.2017.04.006. [PMID: 28411511]
  • Peng-Fei Yang, Zi-Ming Feng, Ya-Nan Yang, Jian-Shuang Jiang, Pei-Cheng Zhang. Neuroprotective Caffeoylquinic Acid Derivatives from the Flowers of Chrysanthemum morifolium. Journal of natural products. 2017 04; 80(4):1028-1033. doi: 10.1021/acs.jnatprod.6b01026. [PMID: 28248102]
  • Amit Rai, Hidetaka Kamochi, Hideyuki Suzuki, Michimi Nakamura, Hiroki Takahashi, Tomoki Hatada, Kazuki Saito, Mami Yamazaki. De novo transcriptome assembly and characterization of nine tissues of Lonicera japonica to identify potential candidate genes involved in chlorogenic acid, luteolosides, and secoiridoid biosynthesis pathways. Journal of natural medicines. 2017 Jan; 71(1):1-15. doi: 10.1007/s11418-016-1041-x. [PMID: 27629269]
  • Jia-xin Fan, Shuai Wang, Xian-sheng Meng, Yong-rui Bao, Tian-jiao Li. [Study of cancer cell apoptosis induced by Schizonepeta tenuifolia with microfluidic chip technology]. Yao xue xue bao = Acta pharmaceutica Sinica. 2017 01; 52(1):126-31. doi: . [PMID: 29911809]
  • Shuang Liu, Jian Yang, Liang-Ping Zha, Yu-Yang Zhao, Yong Liu, Yuan Yuan, Lu-Qi Huang. [Research of regulating synthesis of luteolin and luteoloside of Lonicera japonica by LjFNS Ⅱ 1.1 and LjFNS Ⅱ 2.1 treated with 5-azaC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2016 Oct; 41(19):3597-3601. doi: 10.4268/cjcmm20161916. [PMID: 28925154]
  • Secil Yazici-Tutunis, Ebru Gurel-Gurevin, Savas Ustunova, Cihan Demirci-Tansel, Filiz Mericli. Possible effects of Phillyrea latifolia on weight loss in rats fed a high-energy diet. Pharmaceutical biology. 2016 Oct; 54(10):1991-7. doi: 10.3109/13880209.2015.1137952. [PMID: 26850900]
  • Bo Zhang, Tiegui Nan, Zhilai Zhan, Liping Kang, Jian Yang, Yuan Yuan, Baomin Wang, Luqi Huang. Development of a monoclonal antibody-based enzyme-linked immunosorbent assay for luteoloside detection in Flos Lonicerae Japonicae. Analytical and bioanalytical chemistry. 2016 Sep; 408(22):6053-61. doi: 10.1007/s00216-016-9396-0. [PMID: 26892641]
  • Bo Liu, Yu-Zhen Xie, Xiao-Xiu Li, Ying-Ying Sun, Fang Xu, Teng-Fei Ji. [Chemical constituents of Myripnois dioica]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2016 Sep; 41(17):3260-3264. doi: 10.4268/cjcmm20161723. [PMID: 28920380]
  • Yanqing Zang, Kiharu Igarashi, Yu Li. Anti-diabetic effects of luteolin and luteolin-7-O-glucoside on KK-A(y) mice. Bioscience, biotechnology, and biochemistry. 2016 Aug; 80(8):1580-6. doi: 10.1080/09168451.2015.1116928. [PMID: 27170065]
  • Malek Besbes Hlila, Habib Mosbah, Nahla Zanina, Aymen Ben Nejma, Hichem Ben Jannet, Mahjoub Aouni, Boulbaba Selmi. Characterisation of phenolic antioxidants in Scabiosa arenaria flowers by LC-ESI-MS/MS and NMR. The Journal of pharmacy and pharmacology. 2016 Jul; 68(7):932-40. doi: 10.1111/jphp.12561. [PMID: 27230582]
  • Michael Plioukas, Chrysi Gabrieli, Diamanto Lazari, Eugene Kokkalou. Phytochemical analysis with the antioxidant and aldose reductase inhibitory capacities of Tephrosia humilis aerial parts' extracts. Natural product research. 2016 Jun; 30(12):1366-72. doi: 10.1080/14786419.2015.1057729. [PMID: 26209262]
  • Ivana Kroslakova, Simona Pedrussio, Evelyn Wolfram. Direct Coupling of HPTLC with MALDI-TOF MS for Qualitative Detection of Flavonoids on Phytochemical Fingerprints. Phytochemical analysis : PCA. 2016 May; 27(3-4):222-8. doi: 10.1002/pca.2621. [PMID: 27313160]
  • Yi Sun, Ying Wang, Bi-lin Tan, Yan-ru Deng. [Comparison of Six Flavonoid Components of Closely-Related Plants Agrimonia pilosa,Potentilla chinensis and Potentilla discolor]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2016 May; 39(5):991-5. doi: . [PMID: 30132635]
  • N M Ammar, S S El-Hawary, D A Mohamed, A M El-Halawany, A A El-Anssary, L T Abou El-Kassem, R A Hussein, G A Abdel Jaleel, A H El-Dosoky. Estrogenic Activity Including Bone Enhancement and Effect on Lipid Profile of Luteolin-7-O-glucoside Isolated from Trifolium alexandrinum L. in Ovariectomized Rats. Phytotherapy research : PTR. 2016 May; 30(5):768-73. doi: 10.1002/ptr.5564. [PMID: 27145225]
  • Jing Chen, Yang Wang, Xinlei Liang, Tingting Sun, Jinghan Luo, Xingjie Guo, Longshan Zhao. Simultaneous determination of shanzhiside methyl ester, 8-O-acetylshan- zhiside methyl ester and luteolin-7-O-β-D-glucopyranoside in rat plasma by ultra performance liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study after oral administration of Lamiophlomis rotata Pill. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 May; 1020(?):62-6. doi: 10.1016/j.jchromb.2016.03.021. [PMID: 27023158]
  • Anxy Lim, Nusrat Subhan, Jalal A Jazayeri, George John, Thiru Vanniasinkam, Hassan K Obied. Plant Phenols as Antibiotic Boosters: In Vitro Interaction of Olive Leaf Phenols with Ampicillin. Phytotherapy research : PTR. 2016 Mar; 30(3):503-9. doi: 10.1002/ptr.5562. [PMID: 26931616]
  • Zeyu Cao, Yue Ding, Zhipeng Ke, Liang Cao, Na Li, Gang Ding, Zhenzhong Wang, Wei Xiao. Luteoloside Acts as 3C Protease Inhibitor of Enterovirus 71 In Vitro. PloS one. 2016; 11(2):e0148693. doi: 10.1371/journal.pone.0148693. [PMID: 26870944]
  • Jin Qi, You-Hua Chen, Ying Wang, Xi Chen, Lu Wang, Yuan-Jia Hu, Bo-Yang Yu. Screening of peroxynitrite scavengers in Flos Lonicerae by using two new methods, an HPLC-DAD-CL technique and a peroxynitrite spiking test followed by HPLC-DAD analysis. Phytochemical analysis : PCA. 2016 Jan; 27(1):57-63. doi: 10.1002/pca.2599. [PMID: 26567775]
  • Hong Liu, Yan-fang Zheng, Chu-yuan Li, Yu-ying Zheng, De-qin Wang, Zhong Wu, Lin Huang, Yong-gang Wang, Pei-bo Li, Wei Peng, Wei-wei Su. Discovery of Anti-inflammatory Ingredients in Chinese Herbal Formula Kouyanqing Granule based on Relevance Analysis between Chemical Characters and Biological Effects. Scientific reports. 2015 Dec; 5(?):18080. doi: 10.1038/srep18080. [PMID: 26657159]
  • Chin-Feng Hsuan, Hsia-Fen Hsu, Wei-Kung Tseng, Thung-Lip Lee, Yu-Feng Wei, Kwan-Lih Hsu, Chau-Chung Wu, Jer-Yiing Houng. Glossogyne tenuifolia Extract Inhibits TNF-α-Induced Expression of Adhesion Molecules in Human Umbilical Vein Endothelial Cells via Blocking the NF-kB Signaling Pathway. Molecules (Basel, Switzerland). 2015 Sep; 20(9):16908-23. doi: 10.3390/molecules200916908. [PMID: 26393541]
  • Lie-Chwen Lin, Yu-Feng Pai, Tung-Hu Tsai. Isolation of Luteolin and Luteolin-7-O-glucoside from Dendranthema morifolium Ramat Tzvel and Their Pharmacokinetics in Rats. Journal of agricultural and food chemistry. 2015 Sep; 63(35):7700-6. doi: 10.1021/jf505848z. [PMID: 25625345]
  • Wei Yin, Zu-rong Song, Jin-qi Liu, Guo-sheng Zhang. [Chemical Constituents of Paris polyphylla var. chinensis Aerial Parts]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Sep; 38(9):1875-8. doi: ". [PMID: 26930982]
  • Chi-Chih Chang, Sheau Ling Ho, Shoei-Sheng Lee. Acylated glucosylflavones as α-glucosidase inhibitors from Tinospora crispa leaf. Bioorganic & medicinal chemistry. 2015 Jul; 23(13):3388-96. doi: 10.1016/j.bmc.2015.04.053. [PMID: 25999202]
  • Souichi Nakashima, Yoshimi Oda, Seikou Nakamura, Jiang Liu, Koko Onishi, Miki Kawabata, Hisako Miki, Yugo Himuro, Masayuki Yoshikawa, Hisashi Matsuda. Inhibitors of melanogenesis in B16 melanoma 4A5 cells from flower buds of Lawsonia inermis (Henna). Bioorganic & medicinal chemistry letters. 2015 Jul; 25(13):2702-6. doi: 10.1016/j.bmcl.2015.04.052. [PMID: 25987378]
  • Wen Hu, Ting Guo, Wen-Jun Jiang, Guang-Li Dong, Da-Wei Chen, Shi-Lin Yang, He-Ran Li. Effects of ultrahigh pressure extraction on yield and antioxidant activity of chlorogenic acid and cynaroside extracted from flower buds of Lonicera japonica. Chinese journal of natural medicines. 2015 Jun; 13(6):445-53. doi: 10.1016/s1875-5364(15)30038-8. [PMID: 26073341]
  • Imen Samet, Myra O Villareal, Hideko Motojima, Junkyu Han, Sami Sayadi, Hiroko Isoda. Olive leaf components apigenin 7-glucoside and luteolin 7-glucoside direct human hematopoietic stem cell differentiation towards erythroid lineage. Differentiation; research in biological diversity. 2015 Jun; 89(5):146-55. doi: 10.1016/j.diff.2015.07.001. [PMID: 26299581]
  • Qiang Wei, Xiao-ying Ji, Fei Xu, Qian-rong Li, Hao Yin. [Chemical Constituents from Leaves of Hibiscus syriacus and Their α-Glucosidase Inhibitory Activities]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 May; 38(5):975-9. doi: . [PMID: 26767290]
  • Bui Thi Thuy Luyen, Bui Huu Tai, Nguyen Phuong Thao, Ji Yun Cha, Hoon Yeon Lee, Young Mi Lee, Young Ho Kim. Anti-inflammatory components of Chrysanthemum indicum flowers. Bioorganic & medicinal chemistry letters. 2015 Jan; 25(2):266-9. doi: 10.1016/j.bmcl.2014.11.054. [PMID: 25497988]
  • D Russo, N Malafronte, D Frescura, G Imbrenda, I Faraone, L Milella, E Fernandez, N De Tommasi. Antioxidant activities and quali-quantitative analysis of different Smallanthus sonchifolius [(Poepp. and Endl.) H. Robinson] landrace extracts. Natural product research. 2015; 29(17):1673-7. doi: 10.1080/14786419.2014.990906. [PMID: 25533266]
  • Jin-Long Li, Li-Xin Gao, Fan-Wang Meng, Chun-Lan Tang, Ru-Jun Zhang, Jing-Ya Li, Cheng Luo, Jia Li, Wei-Min Zhao. PTP1B inhibitors from stems of Angelica keiskei (Ashitaba). Bioorganic & medicinal chemistry letters. 2015; 25(10):2028-32. doi: 10.1016/j.bmcl.2015.04.003. [PMID: 25891102]
  • Irina Iakovleva, Afshan Begum, Malgorzata Pokrzywa, Malin Walfridsson, A Elisabeth Sauer-Eriksson, Anders Olofsson. The flavonoid luteolin, but not luteolin-7-O-glucoside, prevents a transthyretin mediated toxic response. PloS one. 2015; 10(5):e0128222. doi: 10.1371/journal.pone.0128222. [PMID: 26020516]
  • Ying Zhang, Long-yun Li, Peng Ma, Guang-lin Cui. [Effects of Aphid Occurring on Lonicera macranthoides Bud Yield and Quality]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Jan; 38(1):8-10. doi: . [PMID: 26214864]
  • Zhu-can Lin, Lin Qiu, Ying-juan Fang, An-yu Huang, Su-hua Guo. [Chemical constituents from ethyl acetate extract of Sedum aizoon]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2014 Oct; 37(10):1792-5. doi: . [PMID: 25895385]
  • Liwu Chen, Jian Du, Qiwen Dai, Hongcheng Zhang, Wensheng Pang, Juan Hu. Prediction of anti-tumor chemical probes of a traditional Chinese medicine formula by HPLC fingerprinting combined with molecular docking. European journal of medicinal chemistry. 2014 Aug; 83(?):294-306. doi: 10.1016/j.ejmech.2014.06.037. [PMID: 24974349]
  • Margarita H Ahmad-Qasem, Jaime Cánovas, Enrique Barrajón-Catalán, José E Carreres, Vicente Micol, José V García-Pérez. Influence of olive leaf processing on the bioaccessibility of bioactive polyphenols. Journal of agricultural and food chemistry. 2014 Jul; 62(26):6190-8. doi: 10.1021/jf501414h. [PMID: 24926566]
  • Hui-Peng Song, Hui Zhang, Yu Fu, Hua-yan Mo, Mu Zhang, Jun Chen, Ping Li. Screening for selective inhibitors of xanthine oxidase from Flos Chrysanthemum using ultrafiltration LC-MS combined with enzyme channel blocking. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Jun; 961(?):56-61. doi: 10.1016/j.jchromb.2014.05.001. [PMID: 24861872]
  • Ewa Skrzypczak-Pietraszek, Jacek Pietraszek. Seasonal changes of flavonoid content in Melittis melissophyllum L. (Lamiaceae). Chemistry & biodiversity. 2014 Apr; 11(4):562-70. doi: 10.1002/cbdv.201300148. [PMID: 24706626]
  • Yuan-Yuan Jia, Rong-Fa Guan, Yi-Hang Wu, Xiao-Ping Yu, Wen-Yan Lin, Yong-Yong Zhang, Tao Liu, Jun Zhao, Shu-Yun Shi, Yu Zhao. Taraxacum mongolicum extract exhibits a protective effect on hepatocytes and an antiviral effect against hepatitis B virus in animal and human cells. Molecular medicine reports. 2014 Apr; 9(4):1381-7. doi: 10.3892/mmr.2014.1925. [PMID: 24481875]
  • Lei Chen, Young-Hwa Kang. Antioxidant and enzyme inhibitory activities of Plebeian herba (Salvia plebeia R. Br.) under different cultivation conditions. Journal of agricultural and food chemistry. 2014 Mar; 62(10):2190-7. doi: 10.1021/jf404570s. [PMID: 24422962]
  • Sumaira Sahreen, Muhammad Rashid Khan, Rahmat Ali Khan. Comprehensive assessment of phenolics and antiradical potential of Rumex hastatus D. Don. roots. BMC complementary and alternative medicine. 2014 Feb; 14(?):47. doi: 10.1186/1472-6882-14-47. [PMID: 24507200]
  • Fei-hong Zuo, Guo-jiang Wu, Jin-jin Li, Guo-ping Zhou, Hui-zheng Fu, Yuan-yue Liao. [Chemical constituents of Salix matsudana leaf]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2013 Dec; 36(12):1959-62. doi: . [PMID: 25090681]
  • Yuanzhang Yao, Jie Yang, Dawei Wang, Fei Zhou, Xueting Cai, Wuguang Lu, Chunping Hu, Zhenghua Gu, Shihui Qian, Xiaoxiang Guan, Peng Cao. The aqueous extract of Lycopus lucidus Turcz ameliorates streptozotocin-induced diabetic renal damage via inhibiting TGF-β1 signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2013 Oct; 20(13):1160-7. doi: 10.1016/j.phymed.2013.06.004. [PMID: 23827664]
  • Esma Kozan, Serap Arabaci Anul, I Irem Tatli. In vitro anthelmintic effect of Vicia pannonica var. purpurascens on trichostrongylosis in sheep. Experimental parasitology. 2013 Jul; 134(3):299-303. doi: 10.1016/j.exppara.2013.03.018. [PMID: 23562885]
  • Sinikka Rahte, Richard Evans, Philippe J Eugster, Laurence Marcourt, Jean-Luc Wolfender, Andreas Kortenkamp, Deniz Tasdemir. Salvia officinalis for hot flushes: towards determination of mechanism of activity and active principles. Planta medica. 2013 Jun; 79(9):753-60. doi: 10.1055/s-0032-1328552. [PMID: 23670626]
  • Feng Qiu, Zhaoxia Li, Lang He, Dan Wang. HPLC-ESI-MS/MS analysis and pharmacokinetics of luteoloside, a potential anticarcinogenic component isolated from Lonicera japonica, in beagle dogs. Biomedical chromatography : BMC. 2013 Mar; 27(3):311-7. doi: 10.1002/bmc.2793. [PMID: 22865633]
  • R Quirantes-Piné, G Zurek, E Barrajón-Catalán, C Bäßmann, V Micol, A Segura-Carretero, A Fernández-Gutiérrez. A metabolite-profiling approach to assess the uptake and metabolism of phenolic compounds from olive leaves in SKBR3 cells by HPLC-ESI-QTOF-MS. Journal of pharmaceutical and biomedical analysis. 2013 Jan; 72(?):121-6. doi: 10.1016/j.jpba.2012.09.029. [PMID: 23146235]
  • Ran Yin, Fei Han, Zheng Tang, Ran Liu, Xu Zhao, Xiaohui Chen, Kaishun Bi. UFLC-MS/MS method for simultaneous determination of luteolin-7-O-gentiobioside, luteolin-7-O-β-D-glucoside and luteolin-7-O-β-D-glucuronide in beagle dog plasma and its application to a pharmacokinetic study after administration of traditional Chinese medicinal preparation: Kudiezi injection. Journal of pharmaceutical and biomedical analysis. 2013 Jan; 72(?):127-33. doi: 10.1016/j.jpba.2012.09.028. [PMID: 23146236]
  • Qi-Shi-San Wu, Qing-Hu Wang, Yin-Tai Na. [Study on chemical constituents of Ixeris chinensis]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2012 Dec; 35(12):1945-9. doi: . [PMID: 23705357]
  • Qi-Mei Liu, Hai-Yan Zhao, Xian-Ke Zhong, Jian-Guo Jiang. Eclipta prostrata L. phytochemicals: isolation, structure elucidation, and their antitumor activity. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2012 Nov; 50(11):4016-22. doi: 10.1016/j.fct.2012.08.007. [PMID: 22902823]