Benzyl isothiocyanate (BioDeep_00000000734)

Main id: BioDeep_00000266580

Secondary id: BioDeep_00000862717

human metabolite PANOMIX_OTCML-2023 Chemicals and Drugs natural product


代谢物信息卡片


4-12-00-02276 (Beilstein Handbook Reference)

化学式: C8H7NS (149.0299)
中文名称: 苄基异硫氰酸酯, 异硫氰酸苄酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C=C1)CN=C=S
InChI: InChI=1S/C8H7NS/c10-7-9-6-8-4-2-1-3-5-8/h1-5H,6H2

描述信息

Benzyl isothiocyanate, also known as alpha-isothiocyanatotoluene or isothiocyanic acid, benzyl ester, belongs to benzene and substituted derivatives class of compounds. Those are aromatic compounds containing one monocyclic ring system consisting of benzene. Benzyl isothiocyanate is practically insoluble (in water) and an extremely weak basic (essentially neutral) compound (based on its pKa). Benzyl isothiocyanate is a mild, dusty, and horseradish tasting compound and can be found in a number of food items such as cabbage, garden onion, garden cress, and papaya, which makes benzyl isothiocyanate a potential biomarker for the consumption of these food products. Benzyl isothiocyanate (BITC) is an isothiocyanate found in plants of the mustard family .
Benzyl isothiocyanate is an isothiocyanate and a member of benzenes. It has a role as an antibacterial drug.
Benzyl isothiocyanate is a natural product found in Erucaria microcarpa, Simicratea welwitschii, and other organisms with data available.
See also: Lepidium meyenii root (part of).
Benzyl isothiocyanate is found in brassicas. Benzyl isothiocyanate is isolated from Tropaeolum majus (garden nasturtium) and Lepidium sativum (garden cress), also in other plants especially in the Cruciferae. Potential nutriceutical.
Benzyl isothiocyanate is a member of natural isothiocyanates with antimicrobial activity[1][2]. Benzyl isothiocyanate potent inhibits cell mobility, migration and invasion nature and matrix metalloproteinase-2 (MMP-2) activity of murine melanoma cells[2].
Benzyl isothiocyanate is a member of natural isothiocyanates with antimicrobial activity[1][2]. Benzyl isothiocyanate potent inhibits cell mobility, migration and invasion nature and matrix metalloproteinase-2 (MMP-2) activity of murine melanoma cells[2].

同义名列表

68 个代谢物同义名

4-12-00-02276 (Beilstein Handbook Reference); Benzyl isothiocyanate, analytical standard; (Isothiocyanatomethyl)benzene, 9CI; Isothiocyanic acid, benzyl ester; Toluene, .alpha.-isothiocyanato-; Benzene, (isothiocyanatomethyl)-; 1-(isothiocyanatomethyl)benzene; Benzyl isothiocyanate, 98\\%, FG; Toluene, alpha -isothiocyanato-; Isothiocyanic Acid Benzyl Ester; (Isothiocyanatomethyl)benzene #; (isothiocyanatomethyl)-benzene; Toluene, alpha-isothiocyanato-; (Isothiocyanatomethyl)benzene; isothiocyanato-methyl-benzene; BENZYL ISOTHIOCYANATE (MART.); BENZYLISOTHIOCYANATE [WHO-DD]; BENZYL ISOTHIOCYANATE [MART.]; alpha-Isothiocyanato-Toluene; isothiocyanatomethyl-benzene; BENZYL ISOTHIOCYANATE [FHFI]; Isothiocyanatomethyl)benzene; Isothiocyanate, benzyl ester; Isothiocyanotaomethylbenzene; alpha-isothiocyanatotoluene; isothiocyanatomethylbenzene; Benzyl isothiocyanate, 98\\%; phenylmethyl isothiocyanate; 3-Benzylisothiocyanic acid; Tromalyt active substance; Benzyl isothiocyanic acid; Α-isothiocyanatotoluene; a-Isothiocyanatotoluene; Benzyl isothio cyanate; Benzylsenfoel [German]; 3-Benzylisothiocyanate; Benzylsenfoel (german); Benzyl isothiocyanate; Benzyl-isothiocyanate; benzylisothiocyanate; Benzyl mustard oil; Spectrum2_000852; Spectrum3_000793; Spectrum4_001059; Spectrum5_001837; Benzylsenfoel; DivK1c_006780; NCI60_000455; KBio3_001746; Tox21_201191; KBio2_007457; KBio2_004889; KBio1_001724; KBio2_002321; QTL1_000013; WLN: SCN1R; AB 2 (VAN); Tromocaps; PMITC cpd; AI3-02736; Tromacaps; Tromalyt; BITC, 17; Urogran; AB 2; BITC; Benzyl isothiocyanate; Benzyl isothiocyanate



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

32 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(31)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

61 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 15 ANXA5, BCL2, CASP3, CASP9, CAT, CCNB1, CCND1, CDK1, CDKN1A, CTNNB1, HPGDS, MAPK14, MAPK8, MTOR, PIK3CA
Peripheral membrane protein 4 ANXA5, CYP1B1, GORASP1, MTOR
Endoplasmic reticulum membrane 4 BCL2, CDK1, CYP1B1, MTOR
Nucleus 12 BCL2, CASP3, CASP9, CCNB1, CCND1, CDK1, CDKN1A, CTNNB1, JUN, MAPK14, MAPK8, MTOR
cytosol 15 ANXA5, BCL2, CASP3, CASP9, CAT, CCNB1, CCND1, CDK1, CDKN1A, CTNNB1, HPGDS, MAPK14, MAPK8, MTOR, PIK3CA
dendrite 1 MTOR
nuclear body 1 CDKN1A
phagocytic vesicle 1 MTOR
centrosome 4 CCNB1, CCND1, CDK1, CTNNB1
nucleoplasm 11 CASP3, CCNB1, CCND1, CDK1, CDKN1A, CTNNB1, HPGDS, JUN, MAPK14, MAPK8, MTOR
RNA polymerase II transcription regulator complex 1 JUN
Cell membrane 2 CTNNB1, TNF
Cytoplasmic side 2 GORASP1, MTOR
lamellipodium 2 CTNNB1, PIK3CA
Golgi apparatus membrane 2 GORASP1, MTOR
Synapse 2 CTNNB1, MAPK8
cell cortex 1 CTNNB1
cell junction 1 CTNNB1
cell surface 1 TNF
glutamatergic synapse 3 CASP3, CTNNB1, MAPK14
Golgi apparatus 1 GORASP1
Golgi membrane 3 GORASP1, INS, MTOR
lysosomal membrane 1 MTOR
neuronal cell body 2 CASP3, TNF
presynaptic membrane 1 CTNNB1
sarcolemma 1 ANXA5
Lysosome 1 MTOR
plasma membrane 3 CTNNB1, PIK3CA, TNF
Membrane 8 ANXA5, BCL2, CAT, CCNB1, CDK1, CTNNB1, CYP1B1, MTOR
axon 1 MAPK8
basolateral plasma membrane 1 CTNNB1
extracellular exosome 4 ANXA5, CAT, CDK1, CTNNB1
Lysosome membrane 1 MTOR
endoplasmic reticulum 1 BCL2
extracellular space 2 INS, TNF
perinuclear region of cytoplasm 3 CDKN1A, CTNNB1, PIK3CA
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 2 CCND1, CTNNB1
intercalated disc 1 PIK3CA
mitochondrion 6 BCL2, CASP9, CAT, CDK1, CYP1B1, MAPK14
protein-containing complex 5 BCL2, CASP9, CAT, CDKN1A, CTNNB1
intracellular membrane-bounded organelle 3 CAT, CYP1B1, HPGDS
Microsome membrane 2 CYP1B1, MTOR
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 1 INS
extracellular region 5 ANXA5, CAT, INS, MAPK14, TNF
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, MTOR
mitochondrial matrix 3 CAT, CCNB1, CDK1
transcription regulator complex 2 CTNNB1, JUN
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 CDK1
Nucleus membrane 2 BCL2, CCND1
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, CCND1
external side of plasma membrane 2 ANXA5, TNF
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
nucleolus 1 CDKN1A
Wnt signalosome 1 CTNNB1
midbody 1 CDK1
apical part of cell 1 CTNNB1
cell-cell junction 1 CTNNB1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 1 CTNNB1
Membrane raft 1 TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 CTNNB1
focal adhesion 3 ANXA5, CAT, CTNNB1
cis-Golgi network 1 GORASP1
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 1 MTOR
PML body 1 MTOR
collagen-containing extracellular matrix 1 ANXA5
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
nuclear speck 1 MAPK14
Zymogen granule membrane 1 ANXA5
chromatin 1 JUN
phagocytic cup 1 TNF
cell periphery 1 CTNNB1
mitotic spindle 1 CDK1
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
spindle pole 3 CCNB1, CTNNB1, MAPK14
chromosome, telomeric region 1 CDK1
nuclear chromosome 1 JUN
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
nuclear envelope 1 MTOR
Endomembrane system 2 CTNNB1, MTOR
endosome lumen 1 INS
euchromatin 2 CTNNB1, JUN
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 3 CAT, INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
transcription repressor complex 1 CCND1
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
beta-catenin-TCF complex 1 CTNNB1
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 GORASP1, INS
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
apoptosome 1 CASP9
outer kinetochore 1 CCNB1
presynaptic active zone cytoplasmic component 1 CTNNB1
vesicle membrane 1 ANXA5
protein-DNA complex 1 CTNNB1
spindle microtubule 1 CDK1
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
Cytoplasmic vesicle, phagosome 1 MTOR
catenin complex 1 CTNNB1
cyclin-dependent protein kinase holoenzyme complex 3 CCND1, CDK1, CDKN1A
transcription factor AP-1 complex 1 JUN
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
cyclin A1-CDK1 complex 1 CDK1
cyclin A2-CDK1 complex 1 CDK1
cyclin B1-CDK1 complex 2 CCNB1, CDK1
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CCND1
PCNA-p21 complex 1 CDKN1A
beta-catenin-TCF7L2 complex 1 CTNNB1
cyclin D1-CDK6 complex 1 CCND1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
caspase complex 1 CASP9
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Juan Pedro Rojas-Armas, Miriam Palomino-Pacheco, Jorge Luis Arroyo-Acevedo, José Manuel Ortiz-Sánchez, Hugo Jesús Justil-Guerrero, Jaime Teodocio Martínez-Heredia, Américo Castro-Luna, Crescencio Rodríguez Flores, Aldo Javier Guzmán Duxtan. Phytochemical Profiling by UHPLC-Q-TOF/MS and Chemopreventive Effect of Aqueous Extract of Moringa oleifera Leaves and Benzyl Isothiocyanate on Murine Mammary Carcinogenesis. Molecules (Basel, Switzerland). 2024 Mar; 29(6):. doi: 10.3390/molecules29061380. [PMID: 38543016]
  • Simon P Pfäffle, Corinna Herz, Eva Brombacher, Michele Proietti, Michael Gigl, Christoph K Hofstetter, Verena K Mittermeier-Kleßinger, Sophie Claßen, Hoai T T Tran, Corinna Dawid, Clemens Kreutz, Stefan Günther, Evelyn Lamy. A 14-Day Double-Blind, Randomized, Controlled Crossover Intervention Study with Anti-Bacterial Benzyl Isothiocyanate from Nasturtium (Tropaeolum majus) on Human Gut Microbiome and Host Defense. Nutrients. 2024 Jan; 16(3):. doi: 10.3390/nu16030373. [PMID: 38337658]
  • Lina B Flor-Weiler, Robert W Behle, Mark A Berhow, Susan P McCormick, Steven F Vaughn, Ephantus J Muturi, William T Hay. Bioactivity of brassica seed meals and its compounds as ecofriendly larvicides against mosquitoes. Scientific reports. 2023 Mar; 13(1):3936. doi: 10.1038/s41598-023-30563-6. [PMID: 36894606]
  • Saranya Varadarajan, Balaji Thodur Madapusi, Malathi Narasimhan, Chamundeeswari Durai Pandian, Sakthisekaran Dhanapal. Anticancer Effects of Carica papaya L. and Benzyl Isothiocyanate on an Oral Squamous Cell Carcinoma Cell Line: An In Vitro Study. The journal of contemporary dental practice. 2022 Aug; 23(8):839-844. doi: 10.5005/jp-journals-10024-3384. [PMID: 37283020]
  • Hui-Ju Kim, Ah-Hyeon Jeong, Ji-Hoon Lee, Jun-Hwan Park. Persistence Enhancement of a Promising Tick Repellent, Benzyl Isothiocyanate, by Yeast Microcarriers. Molecules (Basel, Switzerland). 2021 Nov; 26(22):. doi: 10.3390/molecules26226817. [PMID: 34833912]
  • Marta Henklewska, Aleksandra Pawlak, Rong-Fang Li, Jine Yi, Iwona Zbyryt, Bożena Obmińska-Mrukowicz. Benzyl Isothiocyanate, a Vegetable-Derived Compound, Induces Apoptosis via ROS Accumulation and DNA Damage in Canine Lymphoma and Leukemia Cells. International journal of molecular sciences. 2021 Oct; 22(21):. doi: 10.3390/ijms222111772. [PMID: 34769202]
  • Jenny Spöttel, Johannes Brockelt, Sven Falke, Sascha Rohn. Characterization of Conjugates between α-Lactalbumin and Benzyl Isothiocyanate-Effects on Molecular Structure and Proteolytic Stability. Molecules (Basel, Switzerland). 2021 Oct; 26(20):. doi: 10.3390/molecules26206247. [PMID: 34684828]
  • Hongbo Li, Xujia Ming, Dan Xu, Haizhen Mo, Zhenbin Liu, Liangbin Hu, Xiaohui Zhou. Transcriptome Analysis and Weighted Gene Co-expression Network Reveal Multitarget-Directed Antibacterial Mechanisms of Benzyl Isothiocyanate against Staphylococcus aureus. Journal of agricultural and food chemistry. 2021 Oct; 69(39):11733-11741. doi: 10.1021/acs.jafc.1c03979. [PMID: 34558287]
  • Svenja Badekow, Mascha Treblin, Jenny Spöttel, Sascha Rohn. Benzyl isothiocyanate-modified α-lactalbumin - Two-dimensional high-performance thin-layer chromatography for analyzing modified peptides. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2021 Sep; 1181(?):122937. doi: 10.1016/j.jchromb.2021.122937. [PMID: 34536835]
  • N Yamada, W Murata, Y Yamaguchi, K-I Fujita, A Ogita, T Tanaka. Enhancing the fungicidal activity of amphotericin B via vacuole disruption by benzyl isothiocyanate, a cruciferous plant constituent. Letters in applied microbiology. 2021 Apr; 72(4):390-398. doi: 10.1111/lam.13425. [PMID: 33128810]
  • Ping Li, Yi-Meng Zhao, Cui Wang, Hua-Ping Zhu. Antibacterial activity and main action pathway of benzyl isothiocyanate extracted from papaya seeds. Journal of food science. 2021 Jan; 86(1):169-176. doi: 10.1111/1750-3841.15539. [PMID: 33300139]
  • Wei-Ting Chuang, Chih-Ching Yen, Chin-Shiu Huang, Haw-Wen Chen, Chong-Kuei Lii. Benzyl Isothiocyanate Ameliorates High-Fat Diet-Induced Hyperglycemia by Enhancing Nrf2-Dependent Antioxidant Defense-Mediated IRS-1/AKT/TBC1D1 Signaling and GLUT4 Expression in Skeletal Muscle. Journal of agricultural and food chemistry. 2020 Dec; 68(51):15228-15238. doi: 10.1021/acs.jafc.0c06269. [PMID: 33301311]
  • Yue Tang, Xiaohan Wang, Hui Jiang, Liang Song, Haozhe Cui, Zhihui Zhang, Songyi Lin. Pseudosciaena crocea roe protein-stabilized emulsions for oral delivery systems: In vitro digestion and in situ intestinal perfusion study. Journal of food science. 2020 Sep; 85(9):2923-2932. doi: 10.1111/1750-3841.15371. [PMID: 32839962]
  • Linhua Huang, Chunmao Yuan, Yu Wang. Bioactivity-Guided Identification of Anti-Adipogenic Isothiocyanates in the Moringa (Moringa oleifera) Seed and Investigation of the Structure-Activity Relationship. Molecules (Basel, Switzerland). 2020 May; 25(11):. doi: 10.3390/molecules25112504. [PMID: 32481514]
  • Haw-Wen Chen, Chih-Ching Yen, Li-Li Kuo, Chia-Wen Lo, Chin-Shiu Huang, Chih-Chieh Chen, Chong-Kuei Lii. Benzyl isothiocyanate ameliorates high-fat/cholesterol/cholic acid diet-induced nonalcoholic steatohepatitis through inhibiting cholesterol crystal-activated NLRP3 inflammasome in Kupffer cells. Toxicology and applied pharmacology. 2020 04; 393(?):114941. doi: 10.1016/j.taap.2020.114941. [PMID: 32126212]
  • Shin-Ichiro Yokoyama, Miyuki Kodera, Akiko Hirai, Mitsuhiko Nakada, Yuki Ueno, Toshihiko Osawa. Benzyl Isothiocyanate Produced by Garden Cress (Lepidium sativum) Prevents Accumulation of Hepatic Lipids. Journal of nutritional science and vitaminology. 2020; 66(5):481-487. doi: 10.3177/jnsv.66.481. [PMID: 33132353]
  • Toshiyuki Nakamura, Yoshiyuki Murata, Yoshimasa Nakamura. Characterization of benzyl isothiocyanate extracted from mashed green papaya by distillation. Food chemistry. 2019 Nov; 299(?):125118. doi: 10.1016/j.foodchem.2019.125118. [PMID: 31288160]
  • Wei-Ting Chuang, Yun-Ta Liu, Chin-Shiu Huang, Chia-Wen Lo, Hsien-Tsung Yao, Haw-Wen Chen, Chong-Kuei Lii. Benzyl Isothiocyanate and Phenethyl Isothiocyanate Inhibit Adipogenesis and Hepatosteatosis in Mice with Obesity Induced by a High-Fat Diet. Journal of agricultural and food chemistry. 2019 Jun; 67(25):7136-7146. doi: 10.1021/acs.jafc.9b02668. [PMID: 31240929]
  • Lei Ma, Yongjun Chen, Rui Han, Shuangyi Wang. Benzyl isothiocyanate inhibits invasion and induces apoptosis via reducing S100A4 expression and increases PUMA expression in oral squamous cell carcinoma cells. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 2019 Apr; 52(4):e8409. doi: 10.1590/1414-431x20198409. [PMID: 30970087]
  • Su-Hyeong Kim, Shivendra V Singh. Role of Krüppel-like Factor 4-p21CIP1 Axis in Breast Cancer Stem-like Cell Inhibition by Benzyl Isothiocyanate. Cancer prevention research (Philadelphia, Pa.). 2019 03; 12(3):125-134. doi: 10.1158/1940-6207.capr-18-0393. [PMID: 30723175]
  • Qifu Yang, Miku Miyagawa, Xiaoyang Liu, Beiwei Zhu, Shintaro Munemasa, Toshiyuki Nakamura, Yoshiyuki Murata, Yoshimasa Nakamura. Methyl-β-cyclodextrin potentiates the BITC-induced anti-cancer effect through modulation of the Akt phosphorylation in human colorectal cancer cells. Bioscience, biotechnology, and biochemistry. 2018 Dec; 82(12):2158-2167. doi: 10.1080/09168451.2018.1514249. [PMID: 30200817]
  • Ying Liang, Ikumi Sasaki, Yuki Takeda, Beiwei Zhu, Shintaro Munemasa, Toshiyuki Nakamura, Yoshiyuki Murata, Yoshimasa Nakamura. Benzyl isothiocyanate ameliorates lipid accumulation in 3T3-L1 preadipocytes during adipocyte differentiation. Bioscience, biotechnology, and biochemistry. 2018 Dec; 82(12):2130-2139. doi: 10.1080/09168451.2018.1514247. [PMID: 30185113]
  • Mohamed Z M Salem, Said I Behiry, Abdelfattah Z M Salem. Effectiveness of root-bark extract from Salvadora persica against the growth of certain molecularly identified pathogenic bacteria. Microbial pathogenesis. 2018 Apr; 117(?):320-326. doi: 10.1016/j.micpath.2018.02.044. [PMID: 29486275]
  • Subrata K Pore, Eun-Ryeong Hahm, Joseph D Latoche, Carolyn J Anderson, Yongli Shuai, Shivendra V Singh. Prevention of breast cancer-induced osteolytic bone resorption by benzyl isothiocyanate. Carcinogenesis. 2018 02; 39(2):134-145. doi: 10.1093/carcin/bgx114. [PMID: 29040431]
  • Alain Oliveira Dos Santos, Danielle Rocha do Val, Felipe Dantas da Silveira, Francisco Isaac Fernandes Gomes, Hermany Capistrano Freitas, Ellen Lima de Assis, Diana Kelly Castro de Almeida, Igor Iuco Castro da Silva, Francisco Geraldo Barbosa, Jair Mafezoli, Marcos Reinaldo da Silva, Gerly Anne de Castro Brito, Juliana Trindade Clemente-Napimoga, Vicente de Paulo Teixeira de Paulo Teixera Pinto, Gerardo Cristino Filho, Mirna Marques Bezerra, Hellíada Vasconcelos Chaves. Antinociceptive, anti-inflammatory and toxicological evaluation of semi-synthetic molecules obtained from a benzyl-isothiocyanate isolated from Moringa oleifera Lam. in a temporomandibular joint inflammatory hypernociception model in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Feb; 98(?):609-618. doi: 10.1016/j.biopha.2017.12.102. [PMID: 29289835]
  • Imran Khamis, John J Heikkila. Effect of isothiocyanates, BITC and PEITC, on stress protein accumulation, protein aggregation and aggresome-like structure formation in Xenopus A6 kidney epithelial cells. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2018 Jan; 204(?):1-13. doi: 10.1016/j.cbpc.2017.10.011. [PMID: 29100952]
  • Sary Alsanea, Dexi Liu. BITC and S-Carvone Restrain High-Fat Diet-Induced Obesity and Ameliorate Hepatic Steatosis and Insulin Resistance. Pharmaceutical research. 2017 Nov; 34(11):2241-2249. doi: 10.1007/s11095-017-2230-3. [PMID: 28733781]
  • Sabrina Giacoppo, Renato Iori, Placido Bramanti, Emanuela Mazzon. Topical moringin-cream relieves neuropathic pain by suppression of inflammatory pathway and voltage-gated ion channels in murine model of multiple sclerosis. Molecular pain. 2017 Jan; 13(?):1744806917724318. doi: 10.1177/1744806917724318. [PMID: 28741431]
  • Feixia Liu, Han Yang, Limin Wang, Bo Yu. Biosynthesis of the High-Value Plant Secondary Product Benzyl Isothiocyanate via Functional Expression of Multiple Heterologous Enzymes in Escherichia coli. ACS synthetic biology. 2016 12; 5(12):1557-1565. doi: 10.1021/acssynbio.6b00143. [PMID: 27389525]
  • Anuradha Sehrawat, Claudette St Croix, Catherine J Baty, Simon Watkins, Dhanir Tailor, Rana P Singh, Shivendra V Singh. Inhibition of mitochondrial fusion is an early and critical event in breast cancer cell apoptosis by dietary chemopreventative benzyl isothiocyanate. Mitochondrion. 2016 09; 30(?):67-77. doi: 10.1016/j.mito.2016.06.006. [PMID: 27374852]
  • Anuradha Sehrawat, Shivendra V Singh. Short-form RON overexpression augments benzyl isothiocyanate-induced apoptosis in human breast cancer cells. Molecular carcinogenesis. 2016 May; 55(5):473-85. doi: 10.1002/mc.22295. [PMID: 25857724]
  • Valentina Guzmán-Pérez, Christiane Bumke-Vogt, Monika Schreiner, Inga Mewis, Andrea Borchert, Andreas F H Pfeiffer. Benzylglucosinolate Derived Isothiocyanate from Tropaeolum majus Reduces Gluconeogenic Gene and Protein Expression in Human Cells. PloS one. 2016; 11(9):e0162397. doi: 10.1371/journal.pone.0162397. [PMID: 27622707]
  • Niels Agerbirk, Gina Rosalinda De Nicola, Carl Erik Olsen, Caroline Müller, Renato Iori. Derivatization of isothiocyanates and their reactive adducts for chromatographic analysis. Phytochemistry. 2015 Oct; 118(?):109-15. doi: 10.1016/j.phytochem.2015.06.004. [PMID: 26342619]
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