Classification Term: 170355
Alkaloids (ontology term: c3a26bed11a7526e0c11f2290f331141)
found 500 associated metabolites at sub_class metabolite taxonomy ontology rank level.
Ancestor: Alkaloids
Child Taxonomies: There is no child term of current ontology term.
Benzyl isothiocyanate
Benzyl isothiocyanate, also known as alpha-isothiocyanatotoluene or isothiocyanic acid, benzyl ester, belongs to benzene and substituted derivatives class of compounds. Those are aromatic compounds containing one monocyclic ring system consisting of benzene. Benzyl isothiocyanate is practically insoluble (in water) and an extremely weak basic (essentially neutral) compound (based on its pKa). Benzyl isothiocyanate is a mild, dusty, and horseradish tasting compound and can be found in a number of food items such as cabbage, garden onion, garden cress, and papaya, which makes benzyl isothiocyanate a potential biomarker for the consumption of these food products. Benzyl isothiocyanate (BITC) is an isothiocyanate found in plants of the mustard family . Benzyl isothiocyanate is an isothiocyanate and a member of benzenes. It has a role as an antibacterial drug. Benzyl isothiocyanate is a natural product found in Erucaria microcarpa, Simicratea welwitschii, and other organisms with data available. See also: Lepidium meyenii root (part of). Benzyl isothiocyanate is found in brassicas. Benzyl isothiocyanate is isolated from Tropaeolum majus (garden nasturtium) and Lepidium sativum (garden cress), also in other plants especially in the Cruciferae. Potential nutriceutical. Benzyl isothiocyanate is a member of natural isothiocyanates with antimicrobial activity[1][2]. Benzyl isothiocyanate potent inhibits cell mobility, migration and invasion nature and matrix metalloproteinase-2 (MMP-2) activity of murine melanoma cells[2]. Benzyl isothiocyanate is a member of natural isothiocyanates with antimicrobial activity[1][2]. Benzyl isothiocyanate potent inhibits cell mobility, migration and invasion nature and matrix metalloproteinase-2 (MMP-2) activity of murine melanoma cells[2].
Biotin
Biotin (also known as vitamin B7 or vitamin H) is one of the B vitamins.[1][2][3] It is involved in a wide range of metabolic processes, both in humans and in other organisms, primarily related to the utilization of fats, carbohydrates, and amino acids.[4] The name biotin, borrowed from the German Biotin, derives from the Ancient Greek word βίοτος (bíotos; 'life') and the suffix "-in" (a suffix used in chemistry usually to indicate 'forming').[5] Biotin appears as a white, needle-like crystalline solid.[6] Biotin is an organic heterobicyclic compound that consists of 2-oxohexahydro-1H-thieno[3,4-d]imidazole having a valeric acid substituent attached to the tetrahydrothiophene ring. The parent of the class of biotins. It has a role as a prosthetic group, a coenzyme, a nutraceutical, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a mouse metabolite, a cofactor and a fundamental metabolite. It is a member of biotins and a vitamin B7. It is a conjugate acid of a biotinate. A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk. Biotin is a metabolite found in or produced by Escherichia coli (strain K12, MG1655). Biotin is a natural product found in Lysinibacillus sphaericus, Aspergillus nidulans, and other organisms with data available. Biotin is hexahydro-2-oxo-1H-thieno(3,4-d)imidazole-4-pentanoic acid. Growth factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk. The biotin content of cancerous tissue is higher than that of normal tissue. Biotin is an enzyme co-factor present in minute amounts in every living cell. Biotin is also known as vitamin H or B7 or coenzyme R. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk. Biotin has been recognized as an essential nutrient. Our biotin requirement is fulfilled in part through diet, through endogenous reutilization of biotin and perhaps through capture of biotin generated in the intestinal flora. The utilization of biotin for covalent attachment to carboxylases and its reutilization through the release of carboxylase biotin after proteolytic degradation constitutes the biotin cycle. Biotin deficiency is associated with neurological manifestations, skin rash, hair loss and metabolic disturbances that are thought to relate to the various carboxylase deficiencies (metabolic ketoacidosis with lactic acidosis). It has also been suggested that biotin deficiency is associated with protein malnutrition, and that marginal biotin deficiency in pregnant women may be teratogenic. Biotin acts as a carboxyl carrier in carboxylation reactions. There are four biotin-dependent carboxylases in mammals: those of propionyl-CoA (PCC), 3-methylcrotonyl-CoA (MCC), pyruvate (PC) and acetyl-CoA carboxylases (isoforms ACC-1 and ACC-2). All but ACC-2 are mitochondrial enzymes. The biotin moiety is covalently bound to the epsilon amino group of a Lysine residue in each of these carboxylases in a domain 60-80 amino acids long. The domain is structurally similar among carboxylases from bacteria to mammals. There are four biotin-dependent carboxylases in mammals: those of propionyl-CoA (PCC), 3-methylcrotonyl-CoA (MCC), pyruvate (PC) and acetyl-CoA carboxylases (isoforms ACC-1 and ACC-2). All but ACC-2 are mitochondrial enzymes. The biotin moiety is covalently bound to the epsilon amino group of a Lys residue in each of these carboxylases in a domain 60-80 amino acids long. The domain is structurally similar among carboxylases from bacteria to mammals. Evidence is emerging that biotin participates in processes other than classical carboxylation reactions. Specifically, novel roles for biotin in cell signaling, gene expression, and chromatin structure have been identified in recent years. Human cells accumulate biotin by using both the sodium-dependent multivitamin transporter and monocarboxylate transporter 1. These transporters and other biotin-binding proteins partition biotin to compartments involved in biotin signaling: cytoplasm, mitochondria, and nuclei. The activity of cell signals such as biotinyl-AMP, Sp1 and Sp3, nuclear factor (NF)-kappaB, and receptor tyrosine kinases depends on biotin supply. Consistent with a role for biotin and its catabolites in ... Biotin is an enzyme co-factor present in minute amounts in every living cell. Biotin is also known as coenzyme R and vitamin H or B7. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk. Biotin has been recognized as an essential nutrient. Humans fulfill their biotin requirement through their diet through endogenous reutilization of biotin and perhaps through the capture of biotin generated in the intestinal flora. The utilization of biotin for covalent attachment to carboxylases and its reutilization through the release of carboxylase biotin after proteolytic degradation constitutes the biotin cycle. Biotin deficiency is associated with neurological manifestations, skin rash, hair loss, and metabolic disturbances that are thought to relate to the various carboxylase deficiencies (metabolic ketoacidosis with lactic acidosis). It has also been suggested that biotin deficiency is associated with protein malnutrition, and that marginal biotin deficiency in pregnant women may be teratogenic. Biotin acts as a carboxyl carrier in carboxylation reactions. There are four biotin-dependent carboxylases in mammals: those of propionyl-CoA (PCC), 3-methylcrotonyl-CoA (MCC), pyruvate (PC), and acetyl-CoA carboxylases (isoforms ACC-1 and ACC-2). All but ACC-2 are mitochondrial enzymes. The biotin moiety is covalently bound to the epsilon amino group of a lysine residue in each of these carboxylases in a domain 60-80 amino acids long. The domain is structurally similar among carboxylases from bacteria to mammals. Evidence is emerging that biotin participates in processes other than classical carboxylation reactions. Specifically, novel roles for biotin in cell signalling, gene expression, and chromatin structure have been identified in recent years. Human cells accumulate biotin by using both the sodium-dependent multivitamin transporter and monocarboxylate transporter 1. These transporters and other biotin-binding proteins partition biotin to compartments involved in biotin signalling: cytoplasm, mitochondria, and nuclei. The activity of cell signals such as biotinyl-AMP, Sp1 and Sp3, nuclear factor (NF)-kappaB, and receptor tyrosine kinases depends on biotin supply. Consistent with a role for biotin and its catabolites in modulating these cell signals, greater than 2000 biotin-dependent genes have been identified in various human tissues. Many biotin-dependent gene products play roles in signal transduction and localize to the cell nucleus, consistent with a role for biotin in cell signalling. Posttranscriptional events related to ribosomal activity and protein folding may further contribute to the effects of biotin on gene expression. Finally, research has shown that biotinidase and holocarboxylase synthetase mediate covalent binding of biotin to histones (DNA-binding proteins), affecting chromatin structure; at least seven biotinylation sites have been identified in human histones. Biotinylation of histones appears to play a role in cell proliferation, gene silencing, and the cellular response to DNA repair. Roles for biotin in cell signalling and chromatin structure are consistent with the notion that biotin has a unique significance in cell biology (PMID: 15992684, 16011464). Present in many foods; particularly rich sources include yeast, eggs, liver, certain fish (e.g. mackerel, salmon, sardines), soybeans, cauliflower and cow peas. Dietary supplement. Isolated from various higher plant sources, e.g. sweet corn seedlings and radish leaves An organic heterobicyclic compound that consists of 2-oxohexahydro-1H-thieno[3,4-d]imidazole having a valeric acid substituent attached to the tetrahydrothiophene ring. The parent of the class of biotins. [Raw Data] CB004_Biotin_pos_50eV_CB000006.txt [Raw Data] CB004_Biotin_pos_30eV_CB000006.txt [Raw Data] CB004_Biotin_pos_40eV_CB000006.txt [Raw Data] CB004_Biotin_pos_20eV_CB000006.txt [Raw Data] CB004_Biotin_pos_10eV_CB000006.txt [Raw Data] CB004_Biotin_neg_10eV_000006.txt [Raw Data] CB004_Biotin_neg_20eV_000006.txt Biosynthesis Biotin, synthesized in plants, is essential to plant growth and development.[22] Bacteria also synthesize biotin,[23] and it is thought that bacteria resident in the large intestine may synthesize biotin that is absorbed and utilized by the host organism.[18] Biosynthesis starts from two precursors, alanine and pimeloyl-CoA. These form 7-keto-8-aminopelargonic acid (KAPA). KAPA is transported from plant peroxisomes to mitochondria where it is converted to 7,8-diaminopelargonic acid (DAPA) with the help of the enzyme, BioA. The enzyme dethiobiotin synthetase catalyzes the formation of the ureido ring via a DAPA carbamate activated with ATP, creating dethiobiotin with the help of the enzyme, BioD, which is then converted into biotin which is catalyzed by BioB.[24] The last step is catalyzed by biotin synthase, a radical SAM enzyme. The sulfur is donated by an unusual [2Fe-2S] ferredoxin.[25] Depending on the species of bacteria, Biotin can be synthesized via multiple pathways.[24] Biotin (Vitamin B7) is a water-soluble B vitamin and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids[1][2][3]. Biotin, vitamin B7 and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids[1][2][3]. Biotin (Vitamin B7) is a water-soluble B vitamin and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids[1][2][3].
Sulfadiazine
Sulfadiazine is only found in individuals that have used or taken this drug. It is one of the short-acting sulfonamides used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections. [PubChem]Sulfadiazine is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase. This enzyme is needed for the proper processing of para-aminobenzoic acid (PABA) which is essential for folic acid synthesis. The inhibited reaction is necessary in these organisms for the synthesis of folic acid. J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01E - Sulfonamides and trimethoprim > J01EC - Intermediate-acting sulfonamides D - Dermatologicals > D06 - Antibiotics and chemotherapeutics for dermatological use > D06B - Chemotherapeutics for topical use > D06BA - Sulfonamides Antibacterial agent. It is used in some countries for control of bacterial disease in farmed fish. Not approved for aquacultural use in the USA D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents C254 - Anti-Infective Agent > C29739 - Sulfonamide Anti-Infective Agent D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents D000890 - Anti-Infective Agents > D013424 - Sulfanilamides CONFIDENCE standard compound; EAWAG_UCHEM_ID 179 CONFIDENCE standard compound; INTERNAL_ID 1011
Sulfanilamide
Sulfanilamide is only found in individuals that have used or taken this drug. It is a molecule containing the sulfonamide functional group attached to an aniline. [Wikipedia]Sulfanilamide is a competitive inhibitor of bacterial enzyme dihydropteroate synthetase. This enzyme normally uses para-aminobenzoic acid (PABA) for synthesizing the necessary folic acid. The inhibited reaction is normally necessary in these organisms for the synthesis of folic acid. Without it, bacteria cannot replicate. D - Dermatologicals > D06 - Antibiotics and chemotherapeutics for dermatological use > D06B - Chemotherapeutics for topical use > D06BA - Sulfonamides J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01E - Sulfonamides and trimethoprim > J01EB - Short-acting sulfonamides C254 - Anti-Infective Agent > C29739 - Sulfonamide Anti-Infective Agent D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents D000890 - Anti-Infective Agents > D013424 - Sulfanilamides CONFIDENCE standard compound; INTERNAL_ID 1022 KEIO_ID S016
Benzylamine
Benzylamine, also known as a-aminotoluene or moringine, belongs to the class of organic compounds known as phenylmethylamines. Phenylmethylamines are compounds containing a phenylmethtylamine moiety, which consists of a phenyl group substituted by an methanamine. Benzylamine is found, on average, in the highest concentration within a few different foods, such as corns, white cabbages, and cabbages and in a lower concentration in wild carrots, carrots, and apples. Benzylamine has also been detected, but not quantified, in several different foods, such as common chokecherries, black cabbages, macadamia nut (m. tetraphylla), ginsengs, and lettuces. This could make benzylamine a potential biomarker for the consumption of these foods. Alkaloid from Moringa oleifera (horseradish tree) CONFIDENCE standard compound; INTERNAL_ID 8084
goitrin
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D013956 - Antithyroid Agents D000890 - Anti-Infective Agents > D023303 - Oxazolidinones CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2335 INTERNAL_ID 2335; CONFIDENCE Reference Standard (Level 1)
Cyclohexanone
Cyclohexanone is a food flavourant. Present in various plant spp. e.g. Cistus ladaniferus (labdanum). Cyclohexanone is a colorless oily liquid with an odor resembling acetone and peppermint. Cyclohexanone is occasionally found as a volatile component of human urine. Biological fluids such as blood and urine have been shown to contain a large number of components, some of them volatiles (low boiling point) apparently present in all individuals, while others such are much more variable. In some cases differences up to an order of magnitude are observed. Although some of these changes may have dietary origins, others seem to be characteristic of the individual. Cyclohexanone is obtained through oxidation of cyclohexane or dehydrogenation of phenol. Approx. 95\\% of its manuf. is used for the production of nylon. Information on toxicity to human beings is fragmentary. Acute exposure is characterized by irritation of the eyes, nose, and throat. In two persons, drowsiness and renal impairment were found; Like cyclohexanol, cyclohexanone is not carcinogenic and is only moderately toxic, with a TLV of 25 ppm for the vapor. It is an irritant.; The great majority of cyclohexanone is consumed in the production of precursors to Nylon 66 and Nylon 6. About half of the worlds supply is converted to adipic acid, one of two precursors for nylon 66. For this application, the KA oil (see above) is oxidized with nitric acid. The other half of the cyclohexanone supply is converted to the oxime. In the presence of sulfuric acid catalyst, the oxime rearranges to caprolactam, a precursor to nylon 6:; however, there were embryotoxic effects and influence on reproduction Cyclohexanone is well absorbed through the skin, respiratory tract, and alimentary tract. The main metabolic pathway leads to cyclohexanol, which is excreted in urine coupled with glucuronic acid. A high correlation was found between the concentration of cyclohexanone in the working environment and its concentration in urine. Cyclohexanone is formed from the hydrocarbons cyclohexane and 1-, 2-, and 3-hexanol. A patients case report documents the development of anosmia (an olfactory disorder) and rhinitis caused by occupational exposure to organic solvents, including cyclohexanone (PMID: 10476412, 16925936, 16477465); however, these workers were also exposed to other compounds. Hepatic disorders were found in a group of workers exposed for over five years. In animals, cyclohexanone is characterized by relatively low acute toxicity (DL50 by intragastric administration is approx. 2 g/kg body wt.). Effects on the central nervous system (CNS) were found (narcosis), as well as irritation of the eyes and skin. Following multiple administration, effects were found in the CNS, liver, and kidneys as well as irritation of the conjunctiva. Mutagenic and genotoxic effects were found, but no teratogenic effects were detected Cyclohexanone is a colorless oily liquid with an odor resembling acetone and peppermint. Cyclohexanone is occasionally found as a volatile component of human urine. Biological fluids such as blood and urine have been shown to contain a large number of components, some of them volatiles (low boiling point) apparently present in all individuals, while others such are much more variable. In some cases differences up to an order of magnitude are observed. Although some of these changes may have dietary origins, others seem to be characteristic of the individual. Cyclohexanone is obtained through oxidation of cyclohexane or dehydrogenation of phenol. Approx. 95\\% of its manufacturing is used for the production of nylon. Information on toxicity to human beings is fragmentary. Acute exposure is characterized by irritation of the eyes, nose, and throat. In two persons, drowsiness and renal impairment were found; however, these workers were also exposed to other compounds. Hepatic disorders were found in a group of workers exposed for over five years. In animals, cyclohexanone is characterized by relatively low acute toxicity (DL50 by intragastric administration is approximately 2 g/kg body wt.). Effects on the central nervous system (CNS) were found (narcosis), as well as irritation of the eyes and skin. Following multiple administration, effects were found in the CNS, liver, and kidneys as well as irritation of the conjunctiva. Mutagenic and genotoxic effects were found, but no teratogenic effects were detected; however, there were embryotoxic effects and influence on reproduction Cyclohexanone is well absorbed through the skin, respiratory tract, and alimentary tract. The main metabolic pathway leads to cyclohexanol, which is excreted in urine coupled with glucuronic acid. A high correlation was found between the concentration of cyclohexanone in the working environment and its concentration in urine. Cyclohexanone is formed from the hydrocarbons cyclohexane and 1-, 2-, and 3-hexanol. A patients case report documents the development of anosmia (an olfactory disorder) and rhinitis caused by occupational exposure to organic solvents, including cyclohexanone (PMID:10476412, 16925936, 16477465).
Uroporphyrinogen III
Uroporphyrinogens are porphyrinogen variants in which each pyrrole ring has one acetate side chain and one propionate side chain; it is formed by condensation 4 four molecules of porphobilinogen. 4 isomers are possible but only 2 commoly are found, types I and III. Uroporphyrinogen III is a functional intermediate in heme biosynthesis while Uroporphyrinogen I is produced in an abortive side reaction. COVID info from COVID-19 Disease Map Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS
Cichorine
A member of the class of isoindoles that is 6-hydroxy-4-methoxy-5-methyl-2,3-dihydro-1H-isoindol-1-one which is substituted at position 4, 5, and 6 by methoxy, methyl, and hydroxy groups, respectively. A secondary metabolite found in Aspergillus silvativus, Aspergillus nidulans and Alternaria cichorii, it is poisonous to Russian knapweed (Acroptilon repens).
Benzyl ethyl ether
Benzyl ethyl ether is found in cocoa and cocoa products. Benzyl ethyl ether is present in cocoa. Benzyl ethyl ether is a flavouring agent Present in cocoa. Flavouring agent. Benzyl ethyl ether is found in cocoa and cocoa products. (Ethoxymethyl)benzene is an endogenous metabolite.
Goitrin
5-ethenyl-1,3-oxazolidine-2-thione is a member of the class of oxazolidines that is 1,3-oxazolidine substituted by sulfanylidene and ethenyl groups at positions 2 and 5, respectively. It is a member of oxazolidines and an olefinic compound. DL-Goitrin is a natural product found in Isatis tinctoria with data available. D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D013956 - Antithyroid Agents D000890 - Anti-Infective Agents > D023303 - Oxazolidinones (R)-goitrin is a 5-ethenyl-1,3-oxazolidine-2-thione that has R-configuration. It is a constituent of a traditional Chinese herbal medicine, Radix isatidis. It has a role as an antiviral agent and a plant metabolite. It is an enantiomer of a (S)-goitrin. Epigoitrin is a natural product found in Isatis tinctoria, Diplotaxis harra, and other organisms with data available. A 5-ethenyl-1,3-oxazolidine-2-thione that has R-configuration. It is a constituent of a traditional Chinese herbal medicine, Radix isatidis. DL-Goitrin, also called (R, S)- report by the spring, consists of the epigoitrin (reported by the R- Spring) and the spring (-S- reported by spring), and the two mutually isomers, and the mixture is the ingredient of cruciferous vegetables[1]. DL-Goitrin, also called (R, S)- report by the spring, consists of the epigoitrin (reported by the R- Spring) and the spring (-S- reported by spring), and the two mutually isomers, and the mixture is the ingredient of cruciferous vegetables[1]. Epigoitrin is a natural alkaloid from Isatis tinctoria, with antiviral activities. Epigoitrin reduces susceptibility to influenza virus via mitochondrial antiviral signaling[1][2]. Epigoitrin is a natural alkaloid from Isatis tinctoria, with antiviral activities. Epigoitrin reduces susceptibility to influenza virus via mitochondrial antiviral signaling[1][2].
Benzyl isothiocyanate
Benzyl isothiocyanate is a member of natural isothiocyanates with antimicrobial activity[1][2]. Benzyl isothiocyanate potent inhibits cell mobility, migration and invasion nature and matrix metalloproteinase-2 (MMP-2) activity of murine melanoma cells[2]. Benzyl isothiocyanate is a member of natural isothiocyanates with antimicrobial activity[1][2]. Benzyl isothiocyanate potent inhibits cell mobility, migration and invasion nature and matrix metalloproteinase-2 (MMP-2) activity of murine melanoma cells[2].
asterriquinone dimethyl ether
A member of the class of asterriquinones that is asterriquinone in which the hydrogens of both of the hydroxy groups have replaced by methyl groups.
Biotin
A - Alimentary tract and metabolism > A11 - Vitamins D018977 - Micronutrients > D014815 - Vitamins CONFIDENCE standard compound; INTERNAL_ID 1328; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2876; ORIGINAL_PRECURSOR_SCAN_NO 2873 CONFIDENCE standard compound; INTERNAL_ID 1328; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2877; ORIGINAL_PRECURSOR_SCAN_NO 2875 CONFIDENCE standard compound; INTERNAL_ID 1328; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2896; ORIGINAL_PRECURSOR_SCAN_NO 2894 CONFIDENCE standard compound; INTERNAL_ID 1328; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2875; ORIGINAL_PRECURSOR_SCAN_NO 2872 CONFIDENCE standard compound; INTERNAL_ID 1328; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2894; ORIGINAL_PRECURSOR_SCAN_NO 2891 CONFIDENCE standard compound; INTERNAL_ID 1328; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 2908; ORIGINAL_PRECURSOR_SCAN_NO 2906 CONFIDENCE standard compound; INTERNAL_ID 1328; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6231; ORIGINAL_PRECURSOR_SCAN_NO 6229 CONFIDENCE standard compound; INTERNAL_ID 1328; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6248; ORIGINAL_PRECURSOR_SCAN_NO 6246 CONFIDENCE standard compound; INTERNAL_ID 1328; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6251; ORIGINAL_PRECURSOR_SCAN_NO 6246 CONFIDENCE standard compound; INTERNAL_ID 1328; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6253; ORIGINAL_PRECURSOR_SCAN_NO 6251 CONFIDENCE standard compound; INTERNAL_ID 1328; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6265; ORIGINAL_PRECURSOR_SCAN_NO 6263 CONFIDENCE standard compound; INTERNAL_ID 1328; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6256; ORIGINAL_PRECURSOR_SCAN_NO 6253 CONFIDENCE standard compound; INTERNAL_ID 219 INTERNAL_ID 219; CONFIDENCE standard compound relative retention time with respect to 9-anthracene Carboxylic Acid is 0.474 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.471 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.469 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.470 Biotin (Vitamin B7) is a water-soluble B vitamin and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids[1][2][3]. Biotin, vitamin B7 and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids[1][2][3]. Biotin (Vitamin B7) is a water-soluble B vitamin and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids[1][2][3].
Marineosin A
A macrocycle isolated from a marine sediment-derived actinomycete, Streptomyces sp. It exhibits cytotoxicity against colon tumour cell lines.
sulfanilamide
D - Dermatologicals > D06 - Antibiotics and chemotherapeutics for dermatological use > D06B - Chemotherapeutics for topical use > D06BA - Sulfonamides J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01E - Sulfonamides and trimethoprim > J01EB - Short-acting sulfonamides C254 - Anti-Infective Agent > C29739 - Sulfonamide Anti-Infective Agent D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents D000890 - Anti-Infective Agents > D013424 - Sulfanilamides CONFIDENCE standard compound; INTERNAL_ID 576; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3370; ORIGINAL_PRECURSOR_SCAN_NO 3366 CONFIDENCE standard compound; INTERNAL_ID 576; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3389; ORIGINAL_PRECURSOR_SCAN_NO 3387 CONFIDENCE standard compound; INTERNAL_ID 576; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3366; ORIGINAL_PRECURSOR_SCAN_NO 3363 CONFIDENCE standard compound; INTERNAL_ID 576; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3385; ORIGINAL_PRECURSOR_SCAN_NO 3381 CONFIDENCE standard compound; INTERNAL_ID 576; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3372; ORIGINAL_PRECURSOR_SCAN_NO 3369 CONFIDENCE standard compound; INTERNAL_ID 576; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3376; ORIGINAL_PRECURSOR_SCAN_NO 3373 CONFIDENCE standard compound; UCHEM_ID 4195
1-[3-(3,4,5-Trimethoxyphenyl)propanoyl]piperidin-2-one
muscimol
A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita. D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018755 - GABA Agonists D009676 - Noxae > D011042 - Poisons > D009183 - Mycotoxins
sulfadiazine
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01E - Sulfonamides and trimethoprim > J01EC - Intermediate-acting sulfonamides D - Dermatologicals > D06 - Antibiotics and chemotherapeutics for dermatological use > D06B - Chemotherapeutics for topical use > D06BA - Sulfonamides D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents A sulfonamide consisting of pyrimidine with a 4-aminobenzenesulfonamido group at the 2-position. C254 - Anti-Infective Agent > C29739 - Sulfonamide Anti-Infective Agent D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents D000890 - Anti-Infective Agents > D013424 - Sulfanilamides
(12s,15r,16s,17r)-11,11,15-trimethyl-10,19-dioxa-2-azapentacyclo[14.2.1.0³,⁸.0⁹,¹⁸.0¹²,¹⁷]nonadeca-1,3,5,7,9(18)-pentaen-15-ol
3-({7,9-dibromo-10-hydroxy-8-methoxy-6-methyl-1-oxa-2-azaspiro[4.5]deca-2,6,8-trien-3-yl}formamido)propanoic acid
(1'r,3's,7's,8r)-9-hydroxy-4,4,4',4',14'-pentamethyl-12'-methylidene-9',14'-diazaspiro[[1,4]dioxepino[2,3-g]indole-8,5'-tetracyclo[5.5.2.0¹,⁹.0³,⁷]tetradecan]-13'-one
(2r,3s,4r,5r)-6-{[2,2-bis(diisopropylamino)acetyl]oxy}-2,3,4,5-tetrahydroxyhexanoic acid
5-(3-amino-3-carboxypropyl)-1h,2h,3h,8h,9h,10h,11h,11ah,11bh-pyrido[2,1-f]1,6-naphthyridine-8-carboxylic acid
(2r,6r)-11-bromo-5-methyl-2,9-bis(3-methylbut-2-en-1-yl)-7-oxa-5-azatricyclo[6.4.0.0²,⁶]dodeca-1(8),9,11-trien-12-amine
(3r,5s)-5-[(1r,4s,6r,7s,9r,10e,12r,17r,19r,20s,29s,32s)-9,32-dihydroxy-6,10,13,19,20,32-hexamethyl-27-methylidene-33,34,35-trioxa-22-azahexacyclo[27.3.1.1¹,⁴.1⁴,⁷.0¹²,¹⁷.0¹⁷,²³]pentatriaconta-10,13,22-trien-14-yl]-3-methyloxolan-2-one
(3r,8s,11ar,11br)-5-[(3r)-3-amino-3-carboxypropyl]-8-hydroxy-1h,2h,3h,8h,9h,10h,11h,11ah,11bh-pyrido[2,1-f]1,6-naphthyridine-3-carboxylic acid
(2e)-n-(3-{2,6-dibromo-4-[2-(dimethylamino)ethyl]phenoxy}propyl)-3-{3,5-dibromo-4-[3-(dimethylamino)propoxy]phenyl}-n-methylprop-2-enamide
n-{2-hydroxy-1-[(2r,5s,6r)-5-hydroxy-6-methyloxan-2-yl]pyrimidin-4-ylidene}-4-methylpent-2-enamide
(2s,3r,4as,5s,8ar)-5-[(5r)-5-hydroxyoctyl]-2-methyl-decahydroquinolin-3-yl (2e,4e)-octa-2,4-dienoate
n-{1-[(2r,5s,6r)-5-{[(2r,3r,4s,5s,6r)-5-(dimethylamino)-3,4-dihydroxy-6-methyloxan-2-yl]oxy}-6-methyloxan-2-yl]-2-hydroxypyrimidin-4-ylidene}-4-[(4r)-4-(hydroxymethyl)-4-methyl-5-oxoimidazolidin-1-yl]benzamide
(5z)-5-[(2e)-but-2-en-1-ylidene]-1h,2h,3h,6h,7h,7ah-cyclopenta[b]pyridin-1-yl
13-(dimethoxymethyl)-8-oxa-15-azatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadeca-1(15),2,4,6,12(16),13-hexaen-4-ol
(1's,3s,11's)-6'-ethyl-11'-hydroxy-1-methoxy-10'-oxa-5'-azaspiro[indole-3,2'-tricyclo[5.3.1.0⁴,⁸]undecan]-5'-en-2-one
(1r,4s,5r)-4-hydroxy-5-methoxy-13-methyl-6-oxa-13-azapentacyclo[8.6.2.1¹,⁵.0⁷,¹⁷.0¹⁴,¹⁸]nonadeca-7(17),9,14(18)-trien-8-one
(3s)-n-(2-{[(3as,7r,7as)-4,7-dihydroxy-3h,3ah,6h,7h,7ah-imidazo[4,5-c]pyridin-2-yl]amino}-4,5-dihydroxy-6-[(c-hydroxycarbonimidoyloxy)methyl]oxan-3-yl)-6-{[(3s)-3,6-diamino-1-hydroxyhexylidene]amino}-3-[(1-hydroxyethylidene)amino]hexanimidic acid
4-[(3s,3as)-3h,3ah,4h,5h,6h-pyrrolo[1,2-b]pyrazol-3-yl]phenol
4-benzyl-9-{3-[(5-benzyl-3,6-dihydroxy-2,5-dihydropyrazin-2-yl)methyl]indol-1-yl}-6-hydroxy-2,5,16-triazatetracyclo[7.7.0.0²,⁷.0¹⁰,¹⁵]hexadeca-5,10,12,14-tetraen-3-one
n-{2-[(11r)-8-hydroxy-13-oxo-12,15-dioxa-4-azatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁴]hexadeca-1(16),2,4,6,8,10(14)-hexaen-11-yl]ethyl}guanidine
2-(dimethylamino)-n-[3-(1h-indol-3-yl)-1-oxo-1-{[4-(sulfooxy)phenyl]methoxy}propan-2-yl]-4-methylhexanimidic acid
(3s,4s)-2-[(2s)-1-amino-6-{[(2,3-dihydroxyphenyl)(hydroxy)methylidene]amino}hexan-2-yl]-3,7,8-trihydroxy-4-(1h-indol-3-yl)-1-oxo-4h-isoquinoline-3-carboxylic acid
(1'r,3'r,7's,8r,12'r)-9,12'-dihydroxy-4,4,4',4',12',14'-hexamethyl-9',14'-diazaspiro[[1,4]dioxepino[2,3-g]indole-8,5'-tetracyclo[5.5.2.0¹,⁹.0³,⁷]tetradecan]-13'-one
7,9-dibromo-n-(2-{3,5-dibromo-4-[3-({7,9-dibromo-10-hydroxy-8-oxo-1-oxa-2-azaspiro[4.5]deca-2,6-dien-3-yl}formamido)-2-hydroxypropoxy]phenyl}-2-hydroxyethyl)-10-hydroxy-8-oxo-1-oxa-2-azaspiro[4.5]deca-2,6-diene-3-carboxamide
n-methyl-n-[(2z)-3-(methylsulfanyl)prop-2-enoyl]-2-phenylacetamide
n-[4-chloro-6-(ethylimino)-1,3-dihydro-1,3,5-triazin-2-ylidene]propan-2-amine
(2s)-2-({[(3r,4e)-1-[(2s)-6-carbamimidamido-2-[(1-hydroxy-3-methylbut-2-en-1-ylidene)amino]hexanoyl]-4-ethylidene-3-methylpyrrolidin-2-yl](hydroxy)methylidene}amino)-4-methylpentanoic acid
10-chloro-2,2-dimethyl-5-methylidenedeca-7,9-dien-3-yl 1-methylpyrrolidine-2-carboxylate
n-(4,5-dihydroxy-2-{[(1r,2s)-1-hydroxy-1-(4-hydroxy-2-imino-5,6,7,8-tetrahydro-1h-pteridin-6-yl)propan-2-yl]oxy}-6-(hydroxymethyl)oxan-3-yl)ethanimidic acid
[(2r,3s,4s,5r,6s)-6-{[(2s,3r,4r,5r,6s)-2-{[(10r)-10-(acetyloxy)-8-butanoyl-3-hydroxy-1,4,8-triazacyclotridec-3-en-1-yl]oxy}-4,5-dihydroxy-6-methyloxan-3-yl]oxy}-3,4,5-trihydroxyoxan-2-yl]methyl benzoate
n-[3-ethyl-5,8-dihydroxy-3-methyl-7-(2-methylpropyl)-2-oxa-6,9-diazabicyclo[10.2.2]hexadeca-1(14),5,8,10,12,15-hexaen-4-yl]-1-methylpyrrolidine-2-carboximidic acid
2-{2-[1-(dimethylamino)-2-phenylethyl]-1,3-oxazole-5-carbonyl}aniline
7-imino-2-methyl-10,13,15-trioxa-6,8-diazapentacyclo[7.4.1.1³,¹².0⁵,¹¹.0⁵,¹⁴]pentadecane-2,4,12-triol
4-(prop-2-en-1-yl)-5h,6h,7h-cyclopenta[c]pyridine-1,5-diol
n-{2-[5-(4-hydroxyphenyl)-1-methyl-4,8-dioxo-7h-pyrrolo[3,2-f]indol-3-yl]ethyl}-n-methylformamide
n-[(2s,3s,6r,8s)-4-chloro-3-ethenyl-8-hydroxy-3,7,7,10-tetramethyl-9,16-dioxo-10-azatetracyclo[6.6.1.1²,⁶.0¹¹,¹⁵]hexadeca-1(14),4,11(15),12-tetraen-2-yl]carboximidic acid
2-(4-hydroxyphenyl)-5,6-dihydro-4h-1λ⁶,4-thiazine-1,1-dione
2-(4-{4-hexyl-2-oxa-6-azatricyclo[5.3.0.0¹,³]dec-8-en-10-ylidene}but-2-enamido)-4-(c-hydroxycarbonimidoyl)butanoic acid
16,33,36-tribromo-4,17-dihydroxy-12,25-bis(hydroxyimino)-2,19-dioxa-10,27-diazapentacyclo[28.2.2.2²⁰,²³.1³,⁷.1¹⁴,¹⁸]octatriaconta-1(32),3(38),4,6,14,16,18(37),20,22,30,33,35-dodecaene-11,26-dione
3-hydroxy-5-(hydroxymethyl)-2-(sec-butyl)-1h-pyridin-4-one
6-(4-aminobutyl)-3-isopropyl-13-(10-methylundecyl)-1,4,7,10-tetraazacyclotrideca-1,4,7,10-tetraene-2,5,8,11-tetrol
[(2r,3r,4s,5r,6s)-6-{[(2s,3r,4r,5r,6s)-4,5-dihydroxy-2-{4-[(2s)-4-hydroxy-9-[(2z)-3-phenylprop-2-enoyl]-1,5,9-triazacyclotridec-4-en-2-yl]phenoxy}-6-methyloxan-3-yl]oxy}-3,4,5-trihydroxyoxan-2-yl]methyl benzoate
5-{[(3as,6ar)-2-hydroxy-6a-methoxy-1h,3ah,5h,6h-pyrrolo[2,3-d]imidazol-4-yl]methyl}-3,4-dibromobenzene-1,2-diol
4,26-dimethoxy-2-oxa-11,15,20-triazatricyclo[22.3.1.1³,⁷]nonacosa-1(28),3(29),4,6,8,10,20,22,24,26-decaene-10,21,27-triol
3-[(1-{[3-(2-imino-1,3-dihydroimidazol-4-yl)propyl]-c-hydroxycarbonimidoyl}-3-methylbutyl)-c-hydroxycarbonimidoyl]oxirane-2-carboxylic acid
3,3-dimethyl-5-(3,3,3-trichloro-2-methylpropyl)-1-(4,4,4-trichloro-3-methylbutanoyl)pyrrolidine-2,4-dione
n-{12-[(1-hydroxy-2-methylpropylidene)amino]-2-methyl-4,6,11,13-tetraazatricyclo[8.3.0.0³,⁷]trideca-1(10),3(7),5,11-tetraen-5-yl}benzenecarboximidic acid
[(2r,3r,4r,5r)-1-acetyl-3,4,5-tris(acetyloxy)piperidin-2-yl]methyl acetate
(1s,2s,4s,8s)-4-methoxy-14-oxa-7-azatetracyclo[6.6.1.0¹,¹¹.0²,⁷]pentadeca-9,11-dien-13-one
(2s)-2-[(4-{1-hydroxy-3-imino-4h,5h,6h,6ah,7h,9h-imidazo[1,5-f]pteridin-8-yl}phenyl)formamido]pentanedioic acid
3-[2-(hydroxymethyl)-3-methoxyphenyl]-2-(1h-indol-6-yl)-10-methyl-2-azatricyclo[6.3.1.0⁴,¹²]dodeca-1(11),3,6,8(12),9-pentaen-5-one
n-{3-[(3s,5r,8r,9r)-9-hydroxy-8-(2-hydroxy-4-iminopyrimidin-1-yl)-2-(hydroxyimino)-1,7-dioxa-4-azaspiro[4.5]decan-3-yl]propyl}guanidine
5-(dimethylamino)-6,7-dimethoxy-8-(methyldisulfanyl)-3,4-dihydro-2-benzothiopyran-1-one
5-chloro-3-hydroxy-6-methoxy-1-methyl-3-(2-oxopropyl)indol-2-one
(3as)-6-hydroxy-1-(1h-indol-3-yl)-3ah,4h-naphtho[2,1-b]furan-2,5-dione
3-hydroxy-1-isopropyl-1h,6h,7h,8h,8ah-imidazo[1,5-a]pyridin-5-one
5-(2h-1,3-benzodioxol-5-yl)-n-(2-hydroxy-2-methylpropyl)penta-2,4-dienamide
(4s,5s)-2-{[(2r,3r,4s,5r,6r)-3-{[(3s)-6-amino-1-hydroxy-3-[(1-hydroxyethylidene)amino]hexylidene]amino}-4,5-dihydroxy-6-[(c-hydroxycarbonimidoyloxy)methyl]oxan-2-yl]amino}-5-[(1r)-2-amino-1-hydroxyethyl]-4,5-dihydro-3h-imidazole-4-carboxylic acid
1-(6-methyl-2,3,4,5-tetrahydropyridin-2-yl)propan-2-one
15-(dihydroxymethyl)-10-({[5-(dimethylamino)-4-hydroxy-4,6-dimethyloxan-2-yl]oxy}methyl)-12-hydroxy-7-methoxy-6-methyl-11,16-diazatetracyclo[11.2.1.0²,¹¹.0⁴,⁹]hexadeca-4(9),6-diene-5,8-dione
(3s)-n-(2-{[(2z,3ar,7r,7as)-4,7-dihydroxy-1h,3h,3ah,6h,7h,7ah-imidazo[4,5-c]pyridin-2-ylidene]methyl}-4,5-dihydroxy-6-methyloxan-3-yl)-3-amino-6-{[(4s)-4-amino-7-{[(3s)-3,6-diamino-1-hydroxyhexylidene]amino}hept-1-en-2-yl]amino}hexanimidic acid
4-[(2-amino-4,5-dimethylphenyl)imino]-2,6-dihydroxypyrimidin-5-one
(4s,5s,6z,9r,11s)-6-ethylidene-5,9-dihydroxy-3-oxa-1-azatricyclo[5.3.1.0⁴,¹¹]undec-7-en-2-one
(2e)-4-[2-hydroxy-3-(propan-2-ylidene)indol-6-yl]-2-methylbut-2-enimidic acid
(1'r,3's,7's,8r,12's)-4,4,4',4',12'-pentamethyl-9',14'-diazaspiro[[1,4]dioxepino[2,3-g]indole-8,5'-tetracyclo[5.5.2.0¹,⁹.0³,⁷]tetradecan]-13'-ene-9,13'-diol
(1s,4r,7r,9s)-6-hydroxy-9-[(1s,4r,7r,9s)-6-hydroxy-4-isopropyl-3-oxo-2,5,16-triazatetracyclo[7.7.0.0²,⁷.0¹⁰,¹⁵]hexadeca-5,10,12,14-tetraen-9-yl]-4-(2-methylpropyl)-2,5,16-triazatetracyclo[7.7.0.0²,⁷.0¹⁰,¹⁵]hexadeca-5,10,12,14-tetraen-3-one
6-{2-[1-(5-chloro-1h-pyrrol-2-yl)-3-hydroxyprop-1-en-2-yl]-1,3-oxazol-4-yl}-4-methoxy-5-methyl-5,6-dihydropyran-2-one
(1s,14s)-5-methyl-3,6-dioxo-4-sulfanylidene-11-oxa-2,5-diazatricyclo[7.5.0.0²,⁷]tetradeca-7,9,12-trien-14-yl 3-(5-formyl-2-methoxyphenoxy)-4-methoxybenzoate
(1's,3'r,7'r)-9-hydroxy-4,4,4',4',14'-pentamethyldispiro[[1,4]dioxepino[2,3-g]indole-8,5'-[9,14]diazatetracyclo[5.5.2.0¹,⁹.0³,⁷]tetradecane-12',2''-oxiran]-13'-one
methyl (2s)-3-{[(2s)-3-methoxy-2-[(3r)-3-methyl-2,5-dioxopyrrolidin-1-yl]-3-oxopropyl]disulfanyl}-2-[(3r)-3-methyl-2,5-dioxopyrrolidin-1-yl]propanoate
(2r,3s,6s,10r,11s)-5-acetyl-13-methoxy-6-[(7-methoxy-2h-1,3-benzodioxol-5-yl)methyl]-11-phenyl-15,17-dioxa-5,8-diazapentacyclo[10.7.0.0²,¹⁰.0³,⁸.0¹⁴,¹⁸]nonadeca-1(12),13,18-trien-9-one
(8e,22e)-27-methoxy-2-oxa-11,16,20-triazatricyclo[22.2.2.1³,⁷]nonacosa-1(26),3(29),4,6,8,10,20,22,24,27-decaene-4,10,21-triol
7,9-dibromo-n-(2-{3,5-dibromo-4-[3-(dimethylamino)propoxy]phenyl}ethyl)-10-hydroxy-8-methoxy-1-oxa-2-azaspiro[4.5]deca-2,6,8-triene-3-carboxamide
(9z)-n-({[(2r,3r,4r,5r)-2-[(1s)-1,2-dihydroxyethyl]-4,5-dihydroxy-6-(9h-purin-6-ylamino)oxan-3-yl]-c-hydroxycarbonimidoyl}methyl)-14-methylpentadec-9-enimidic acid
2-methoxy-5-methyl-6-[(1e,3e)-3-methyl-4-(1h-pyrrol-2-yl)buta-1,3-dien-1-yl]-3-(2-methylbut-3-en-2-yl)pyran-4-one
methyl 2-hydroxy-3-{4-[5-hydroxy-4-(2-methylpropyl)-2-oxopyrrol-3-yl]phenoxy}propanoate
6-hydroxy-7-(2-methylpropyl)-4-(2-methylpropylidene)-15-oxa-2,5,8-triazatricyclo[8.5.0.0³,⁸]pentadeca-1(10),2,5,11,13-pentaen-9-one
(12e,28e)-16,21,33,36-tetrabromo-12,25-bis(hydroxyimino)-2,18-dioxa-10,27-diazapentacyclo[28.2.2.2¹⁴,¹⁷.1³,⁷.1¹⁹,²³]octatriaconta-1(32),3(38),4,6,10,14,16,19(35),20,22,26,28,30,33,36-pentadecaene-4,11,20,26-tetrol
(1'r,3r,3's,7'r,12'r)-2,12'-dihydroxy-4',4',7,7,12',14'-hexamethyl-9',14'-diazaspiro[chromeno[5,6-b]pyrrole-3,5'-tetracyclo[5.5.2.0¹,⁹.0³,⁷]tetradecan]-13'-one
(1r,4s,5r,7s,8s,12r,15s,16r,18s,19s)-19-(butanoyloxy)-2,13-dioxo-6,17-dioxa-23,24-dithia-3,14-diazaoctacyclo[10.10.2.0¹,¹⁴.0³,¹².0⁴,¹⁰.0⁵,⁷.0¹⁵,²¹.0¹⁶,¹⁸]tetracosa-9,20-dien-8-yl hexanoate
1-hydroxy-3-{[2-(2-methylbut-3-en-2-yl)-1h-indol-3-yl]methylidene}-6h,7h,8h,8ah-pyrrolo[1,2-a]pyrazin-4-one
1-[(7s,7as)-7-hydroxy-5-[(1r)-1-hydroxyethyl]-2h,3h,7h,7ah-cyclopenta[b]pyridin-1-yl]ethanone
5-hydroxy-7,7,9,9-tetramethyl-1h,2h,3h,10bh-pyrrolo[1,2-c]quinazoline-8,10-dione
(10e)-11-[5-({[(3s)-3-carboxy-1-hydroxy-3-methylpropylidene]amino}carbonyl)-4-oxo-1h-pyridin-2-yl]undec-10-enoic acid
5,8,12,13-tetrahydroxy-8-(hydroxymethyl)-3-imino-10-oxa-2,4-diazatricyclo[7.3.1.0¹,⁶]tridecan-11-one
(2s)-n-[(1z)-2-(5-bromo-1h-indol-3-yl)ethenyl]-4-[(2r)-butan-2-yl]-2-isopropyl-5-oxo-1h-imidazole-2-carboximidic acid
(4r)-2-hydroxy-3,4-dihydroquinoline-4-carboximidic acid
(1r,2s,11r,12r,15s,16r,18r)-12-[(1s)-1-hydroxyethyl]-14,20-dioxa-6-azahexacyclo[16.2.1.0¹,⁶.0²,¹⁰.0²,¹⁶.0¹¹,¹⁵]henicos-9-en-13-one
(3s,6s)-3-{[7,7-dimethyl-2-(2-methylbut-3-en-2-yl)-1h-chromeno[5,6-b]pyrrol-3-yl]methyl}-6-methyl-3,6-dihydropyrazine-2,5-diol
(3s,7r,8as)-1,7-dihydroxy-3-(hydroxymethyl)-3h,6h,7h,8h,8ah-pyrrolo[1,2-a]pyrazin-4-one
1-hydroxy-8-methyl-3h,6h,7h,8h,8ah-pyrrolo[1,2-a]pyrazin-4-one
3-[(3r,21s,22s)-16-ethenyl-11-ethyl-12-(hydroxymethylidene)-3-(methoxycarbonyl)-17,21,26-trimethyl-4-oxo-7,23,24,25-tetraazahexacyclo[18.2.1.1⁵,⁸.1¹⁰,¹³.1¹⁵,¹⁸.0²,⁶]hexacosa-1,5(26),6,8,10,13(25),14,16,18,20(23)-decaen-22-yl]propanoic acid
(2s,4e)-4-[(2e)-2-[(4-carboxybutyl)imino]ethylidene]-2,3-dihydro-1h-pyridine-2,6-dicarboxylic acid
6-hydroxy-6-[5-(2-hydroxypropan-2-yl)-2-methyloxolan-2-yl]-3-methyl-1-(1h-pyrrol-2-yl)hexa-2,4-dien-1-one
2-[(2s)-7-methyl-2h,3h-furo[3,2-h]isoquinolin-2-yl]propan-2-ol
3-benzyl-6-(1h-indol-3-ylmethyl)-3,6-dihydropyrazine-2,5-diol
(1r,2r)-2-{1,3-dioxo-6h,7h,8h,9h-naphtho[2,3-f]isoindol-2-yl}cyclohexyl (12s)-12-methyltetradecanoate
(2e)-2-({[(2s,3r)-1-(5-carbamimidamido-3-chloro-4-hydroxy-2-{[hydroxy({4-hydroxy-3-[3-(prop-1-en-2-yl)quinolin-4-yl]phenyl})methylidene]amino}pentanoyl)-3-hydroxy-3-methylpyrrolidin-2-yl](hydroxy)methylidene}amino)-3-methylpent-2-enoic acid
9,13'-dihydroxy-4,4,4',4',11'-pentamethyl-9',14'-diazaspiro[[1,4]dioxepino[2,3-g]indole-8,5'-tetracyclo[5.5.2.0¹,⁹.0³,⁷]tetradecan]-13'-en-10'-one
4,4-dichloro-n-{5-chloro-4-methyl-1-oxo-1-[2-(1,3-thiazol-2-yl)pyrrolidin-1-yl]pentan-2-yl}-n,3-dimethylbutanamide
(1z,4s,5r,14r,15s,16s,19z)-14,16-dihydroxy-15-methoxy-5,6,6,21,21-pentamethyl-3,7,18,23-tetraazaoctacyclo[16.13.0.0³,¹⁶.0⁴,⁷.0⁴,¹⁴.0⁸,¹³.0²²,³⁰.0²⁴,²⁹]hentriaconta-1(31),8,10,12,19,22(30),24,26,28-nonaene-2,17-dione
(10s)-4,6,6,10,12,12,14-heptamethyl-2-thia-7,11-diazatricyclo[8.4.0.0³,⁸]tetradeca-1(14),3,7-triene-5,13-dione
n-(2-{8-hydroxy-13-oxo-12,15-dioxa-4-azatetracyclo[7.6.1.0⁵,¹⁶.0¹⁰,¹⁴]hexadeca-1(16),2,4,6,8,10(14)-hexaen-11-yl}ethyl)guanidine
(2-{2-[(3,4-dihydroxyphenyl)({4-[2-(dimethylamino)ethyl]imidazol-1-yl})methyl]-2h-1,3-benzodioxol-5-yl}ethenyl)oxysulfonic acid
n-(2-carbamimidoylethyl)-4-hydroxy-2-imino-1h,7h-pyrrolo[2,3-d]pyrimidine-5-carboximidic acid
5-(4,5-dimethoxy-2-methylnaphthalen-1-yl)-8-methoxy-1,2,3-trimethyl-3,4-dihydroisoquinolin-6-one
4-chloro-5-hydroxy-6-(sulfooxy)indole-1-sulfonic acid
4-methoxy-14-oxa-7-azatetracyclo[6.6.1.0¹,¹¹.0²,⁷]pentadeca-9,11-dien-13-one
10-hydroxy-3-methoxy-4-methylidene-11-[(1e)-prop-1-en-1-yl]-6-oxa-3-azatricyclo[5.3.1.0¹,⁵]undecane-2,9-dione
6'-acetyl-1,6-dimethoxy-10'-oxa-5'-azaspiro[indole-3,2'-tricyclo[5.3.1.0⁴,⁸]undecan]-5'-en-2-one
(1s,9r,10r)-9-butyl-10-methyl-5,7-diazatricyclo[6.3.1.0⁴,¹²]dodeca-4(12),7-dien-6-imine
2-bromo-6-[(dimethylamino)methyl]-4-(2,4,4-trimethylpentan-2-yl)phenol
(3s,6s)-3-benzyl-6-(1h-indol-3-ylmethyl)-3,6-dihydropyrazine-2,5-diol
(2s)-2-({[(3s)-2-[(2s)-2-amino-3-(1h-indol-3-yl)propanoyl]-6,8-dihydroxy-7-methoxy-3,4-dihydro-1h-isoquinolin-3-yl](hydroxy)methylidene}amino)-5-hydroxy-4-methylpentanoic acid
n-sulfo{[(3as,4r,10as)-5,10,10-trihydroxy-2,6-diimino-hexahydropyrrolo[1,2-c]purin-4-yl]methoxy}carboximidic acid
(3r)-5-hydroxy-3-(3-hydroxypropyl)-1-methyl-6-(phenylmethylidene)-3h-pyrazin-2-one
(3z,8ar)-1,8a-dihydroxy-3-{[2-(2-methylbut-3-en-2-yl)-1h-indol-3-yl]methylidene}-6h,7h,8h-pyrrolo[1,2-a]pyrazin-4-one
(5s,9s,10r)-7,9-dibromo-n-{2-[3,5-dibromo-4-(3-{[(5s,9s,10r)-7,9-dibromo-10-hydroxy-8-oxo-1-oxa-2-azaspiro[4.5]deca-2,6-dien-3-yl]formamido}-2-hydroxypropoxy)phenyl]-2-hydroxyethyl}-10-hydroxy-8-oxo-1-oxa-2-azaspiro[4.5]deca-2,6-diene-3-carboxamide
(3r)-n-{2-[(7ar)-3-oxo-tetrahydropyrrolo[1,2-c][1,3]oxazol-1-ylidene]acetyl}-3-hydroxytetradecanimidic acid
n-[(1ar,2s,6as,6bs)-5-{1-[(1ar,2s,6as,6bs)-4-[(1-hydroxy-3-methylbut-2-en-1-ylidene)amino]-2,6a-dimethyl-6-oxo-1ah,2h,6bh-oxireno[2,3-a]pyrrolizin-5-yl]ethyl}-2,6a-dimethyl-6-oxo-1ah,2h,6bh-oxireno[2,3-a]pyrrolizin-4-yl]-3-methylbut-2-enimidic acid
4-(dimethylamino)-6-(1h-indol-3-yl)-1,3,5-oxadiazin-2-one
(1's,3s,4's,7'r,8's,11'r)-6'-ethyl-6,11'-dihydroxy-1-methoxy-10'-oxa-5'-azaspiro[indole-3,2'-tricyclo[5.3.1.0⁴,⁸]undecan]-5'-en-2-one
(2s)-2-amino-3-(3-bromo-4-methoxyphenyl)-n-(2-{3,5-dibromo-4-[3-(dimethylamino)propoxy]phenyl}ethyl)propanimidic acid
(2s)-n-[(10s,13s,20s,21r)-3,35-dichloro-12-hydroxy-10-isopropyl-8,37,40-trioxa-4,11,22,34,39-pentaazadecacyclo[27.6.1.1²,⁵.1⁶,⁹.1¹⁵,¹⁹.1¹⁸,²¹.0⁷,²⁰.0²⁰,²⁴.0²³,²⁸.0³³,³⁶]tetraconta-1(35),2,4,6,9(39),11,15,17,19(38),23(28),24,26,29(36),30,32-pentadecaen-13-yl]-2-hydroxy-3-methylbutanimidic acid
3,12-diazatetracyclo[8.7.0.0²,⁸.0¹¹,¹⁵]heptadeca-1,5,7,10,12,14,16-heptaene-4,9-dione
(1r,9r,19s,21s)-5-bromo-21-chloro-17-hydroxy-20,20-dimethyl-2,12,16,18-tetraazahexacyclo[10.10.0.0¹,⁹.0²,¹⁹.0³,⁸.0¹⁵,¹⁹]docosa-3,5,7,13,15,17-hexaen-11-one
12-[4-(acetyloxy)-3-methoxyphenyl]-8,16,17,18-tetramethoxy-3-oxo-4-oxa-1-azapentacyclo[11.8.0.0²,¹¹.0⁵,¹⁰.0¹⁴,¹⁹]henicosa-2(11),5(10),6,8,12,14(19),15,17-octaen-7-yl acetate
n-(1-{10-benzyl-8,11-dihydroxy-16-methoxy-2-oxa-6,9,12-triazatricyclo[13.3.1.0³,⁷]nonadeca-1(18),8,11,13,15(19),16-hexaen-6-yl}-1-oxo-3-phenylpropan-2-yl)-2-(methylamino)-3-phenylpropanimidic acid
(3s)-n-[(2r,3r,4s,5r,6r)-2-{[(3as,7r,7as)-4,7-dihydroxy-3h,3ah,6h,7h,7ah-imidazo[4,5-c]pyridin-2-yl]amino}-4,5-dihydroxy-6-[(c-hydroxycarbonimidoyloxy)methyl]oxan-3-yl]-3,6-diaminohexanimidic acid
(1r,2r)-2-{1,3-dioxo-6h,7h,8h,9h-naphtho[2,3-f]isoindol-2-yl}cyclohexyl (14s)-14-methylhexadecanoate
[(2r,3s,4s,5r,6s)-6-{[(2s,3r,4r,5r,6s)-2-{4-[(2s,11r)-11-(acetyloxy)-4-hydroxy-9-(2-methylpropanoyl)-1,5,9-triazacyclotridec-4-en-2-yl]phenoxy}-4,5-dihydroxy-6-methyloxan-3-yl]oxy}-3,4,5-trihydroxyoxan-2-yl]methyl benzoate
n-[(2r,3r,4s,5r,6r)-2-{[(3as,7r,7as)-4,7-dihydroxy-3h,3ah,6h,7h,7ah-imidazo[4,5-c]pyridin-2-yl]amino}-4,5-dihydroxy-6-[(c-hydroxycarbonimidoyloxy)methyl]oxan-3-yl]-3-amino-6-{[(3s)-3-amino-6-{[(3s)-3-amino-6-{[(3s)-3,6-diamino-1-hydroxyhexylidene]amino}-1-hydroxyhexylidene]amino}-1-hydroxyhexylidene]amino}hexanimidic acid
4,10-dihydroxy-7,8-dioxo-1h,2h,3h,4h-cyclohexa[c]1,5-naphthyridine-2-carboxylic acid
2-(1-amino-6-{[(2,3-dihydroxyphenyl)(hydroxy)methylidene]amino}hexan-2-yl)-3,7,8-trihydroxy-1-oxo-4-phenyl-4h-isoquinoline-3-carboxylic acid
[(2r,3r,4s,5r,6s)-6-{[(2s,3r,4r,5r,6s)-4,5-dihydroxy-2-{4-[(2s)-4-hydroxy-9-[(2e)-3-phenylprop-2-enoyl]-1,5,9-triazacyclotridec-4-en-2-yl]phenoxy}-6-methyloxan-3-yl]oxy}-3,4,5-trihydroxyoxan-2-yl]methyl benzoate
(2s,10r,11r,18r)-2-hydroxy-4,6-dimethoxy-10-(4-methoxyphenyl)-11-phenyl-9-oxa-14,19-diazapentacyclo[10.7.0.0²,¹⁰.0³,⁸.0¹⁴,¹⁸]nonadeca-1(12),3,5,7-tetraen-13-one
7-ethenyl-12-ethyl-21-hydroxy-6,11,27,28-tetramethyl-20-oxa-2,16,29,30-tetraazaheptacyclo[15.8.1.1³,²⁵.1⁵,⁸.1¹⁰,¹³.1¹⁵,¹⁸.0²¹,²⁶]triaconta-1,3,5,7,9,11,13(29),14,17(26),18(28)-decaene-19,22-dione
n-(2-{3,5-dibromo-4-[3-(dimethylamino)propoxy]phenyl}ethyl)methoxycarboximidic acid
5-hydroxy-6-[1-(c-hydroxycarbonimidoyl)-2-iminoimidazolidin-4-yl]hexanoic acid
3-[4-(1h-indol-3-yl)-2,3,5,6-tetramethoxyphenyl]-1h-indol-5-ol
(3s)-n-[(2r,3r,4s,5r,6r)-2-{[(3as,7r,7as)-4,7-dihydroxy-3h,3ah,6h,7h,7ah-imidazo[4,5-c]pyridin-2-yl]amino}-4,5-dihydroxy-6-[(c-hydroxycarbonimidoyloxy)methyl]oxan-3-yl]-3-amino-6-{[(3s)-3,6-diamino-1-hydroxyhexylidene]amino}hexanimidic acid
16,21,33,36-tetrabromo-4,17-dihydroxy-12,25-bis(hydroxyimino)-2,19-dioxa-10,27-diazapentacyclo[28.2.2.2²⁰,²³.1³,⁷.1¹⁴,¹⁸]octatriaconta-1(32),3(38),4,6,14,16,18(37),20,22,30,33,35-dodecaene-11,26-dione
(2s,3s,6r)-3-{[(3s)-3-carbamimidamido-1-hydroxy-5-(methylamino)pentylidene]amino}-6-(2-hydroxy-4-iminopyrimidin-1-yl)-3,6-dihydro-2h-pyran-2-carboxylic acid
(10r)-2-hydroxy-10-{[(4z)-5-hydroxy-2-imino-3-methylimidazol-4-ylidene]methyl}-1,3,6,8-tetraazatricyclo[6.3.1.0⁴,¹²]dodeca-2,4(12),6-trien-5-one
(2e)-n-{3-[(2s,5s)-5-{3-[(2e)-n,5-dihydroxy-3-methylpent-2-enamido]propyl}-3,6-dihydroxy-2,5-dihydropyrazin-2-yl]propyl}-5-hydroxy-3-methylpent-2-enimidic acid
(2s,6'r)-11'-chloro-4-methyl-6'-(methylamino)-2'-azaspiro[furan-2,7'-tricyclo[6.3.1.0⁴,¹²]dodecane]-1'(11'),3',8'(12'),9'-tetraen-5-one
(5r,10r)-7,9-dibromo-n-[(2r)-4-{[(5s,10r)-7,9-dibromo-10-hydroxy-8-methoxy-1-oxa-2-azaspiro[4.5]deca-2,6,8-trien-3-yl]formamido}-2-hydroxy-3-oxobutyl]-10-hydroxy-8-methoxy-2-azaspiro[4.5]deca-2,6,8-triene-3-carboxamide
5-{2,5-dihydroxy-3h-imidazo[4,5-b]pyridin-6-yl}-6-hydroxypyridine-2,3-dione
(2s,3s)-3-methyl-2-(methylamino)-n-[2-(2,5,6-tribromo-1-methylindol-3-yl)ethyl]pentanimidic acid
6-hydroxy-2-(3-hydroxy-3-methylbutyl)-3h-quinolin-4-one
(8s)-4-methoxy-14-oxa-7-azatetracyclo[6.6.1.0¹,¹¹.0²,⁷]pentadeca-9,11-dien-13-one
n,n'-bis[2-(3,5-diiodo-4-methoxyphenyl)ethyl]ethanediamide
7,12-dihydroxy-4,5,5,14-tetramethyl-3-oxa-9-azatetracyclo[6.6.1.0²,⁶.0¹¹,¹⁵]pentadeca-1,6,8(15),11,13-pentaen-10-one
(3s,8as)-1,7-dihydroxy-3-(2-methylpropyl)-3h,6h,7h,8h,8ah-pyrrolo[1,2-a]pyrazin-4-one
(2-{9-[2-(dimethylamino)ethyl]-3,4,6,7-tetramethoxy-2,8-bis(methylsulfanyl)thianthren-1-yl}ethyl)dimethylamine
8-hydroxy-4,11-dimethyl-1h,2h,3h,5h,6h,8h,9h,9ah,10h-indeno[1,7a-e]azonin-13-one
6'-acetyl-11'-hydroxy-1,6-dimethoxy-10'-oxa-5'-azaspiro[indole-3,2'-tricyclo[5.3.1.0⁴,⁸]undecan]-5'-en-2-one
[(3as,4r,10as)-10,10-dihydroxy-2,6-diimino-hexahydro-1h-pyrrolo[1,2-c]purin-4-yl]methoxycarboximidic acid
n-{2-[(z)-ethylideneamino]phenyl}-n-methylformamide
(2r,5'z)-5'-[(2-hydroxyphenyl)methylidene]-3h-spiro[1-benzofuran-2,2'-pyrazine]-3',6'-diol
3-{[3-amino-1-hydroxy-5-(n-methylcarbamimidamido)pentylidene]amino}-6-(2-hydroxy-4-iminopyrimidin-1-yl)-3,6-dihydro-2h-pyran-2-carboxylic acid
1-(4-hydroxy-2-imino-1,6,7,8-tetrahydropteridin-5-yl)propan-1-one
(7s)-2-ethyl-7-hydroxy-6,7-dihydro-5h-indolizin-3-one
(2s,3s,4r,6s,8s)-4-chloro-3-ethenyl-9-hydroxy-2-isothiocyanato-3,7,7-trimethyl-10-azatetracyclo[6.6.1.1²,⁶.0¹¹,¹⁵]hexadeca-1(14),9,11(15),12-tetraen-16-one
4,5-dibromo-n-{[(2r,6s,10s,11r,12r,13r,14r)-14-chloro-12-{[(4,5-dibromo-1h-pyrrol-2-yl)formamido]methyl}-2,10-dihydroxy-4,8-diimino-3,5,7,9-tetraazatetracyclo[9.3.0.0¹,⁵.0⁶,¹⁰]tetradecan-13-yl]methyl}-1h-pyrrole-2-carboxamide
n-{[(1s,2s,3s,4r,5s,6r,10r,12s)-2-{[(1s,2s,3s,4r,5r,6r,10r,12s)-3,4-bis({[(4,5-dibromo-1h-pyrrol-2-yl)formamido]methyl})-6-hydroxy-8,14-diimino-11-oxa-7,9,13,15-tetraazatetracyclo[10.3.0.0¹,⁵.0⁶,¹⁰]pentadecan-2-yl]oxy}-3-{[(4,5-dibromo-1h-pyrrol-2-yl)formamido]methyl}-6-hydroxy-8,14-diimino-11-oxa-7,9,13,15-tetraazatetracyclo[10.3.0.0¹,⁵.0⁶,¹⁰]pentadecan-4-yl]methyl}-4,5-dibromo-1h-pyrrole-2-carboxamide
5-hydroxy-6-[(4-hydroxyphenyl)methyl]-3-(1h-indol-3-ylmethyl)-1-methyl-3,6-dihydropyrazin-2-one
5,6-dichloro-2-[(1e)-3-(5,6-dichloro-1,3-diethyl-1,3-benzodiazol-2-ylidene)prop-1-en-1-yl]-1,3-diethyl-2h-1,3-benzodiazol-2-yl
6,7-dimethoxy-1,2-dimethyl-3,4-dihydroisoquinolin-8-one
bis(4-hydroxy-3-(hydroxyimino)cyclohexa-1,5-diene-1-carbaldehyde); 6-(hydroxyimino)-4-(hydroxymethyl)cyclohexa-2,4-dien-1-ol
[(6s,8ar)-8-hydroxy-8a-(hydroxymethyl)-1-methyl-2,5-dioxo-3h,6h-imidazo[1,2-a]pyrazin-6-yl]methyl 2,3-dihydroxy-2-(hydroxymethyl)-1,4-benzoxazine-5-carboxylate
n-[(2s)-3-(4-chloro-1h-indol-3-yl)-1-methoxy-1-oxopropan-2-yl]-3-methoxy-3-oxopropanimidic acid
(s)-({[(4s)-2-(6-chloro-4-hydroxy-1-methylindol-3-yl)-4-methyl-5h-1,3-oxazol-4-yl](hydroxy)methylidene}amino)((2r)-pyrrolidin-2-yl)acetic acid
10-hydroxy-3-(2-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl)-5-oxa-1-azatricyclo[5.2.1.0⁴,¹⁰]decane-2,6-dione
1-hydroxy-21-methoxy-12-(4-methoxyphenyl)-11-phenyl-13,17,19-trioxa-3,8-diazahexacyclo[10.10.0.0²,¹⁰.0⁴,⁸.0¹⁴,²².0¹⁶,²⁰]docosa-2(10),14,16(20),21-tetraen-9-one
(13e)-1-amino-13-(2-hydroxyethylidene)-11-methyl-6-azatricyclo[7.3.1.0²,⁷]trideca-2,4,6,10-tetraen-5-ol
(2s,6's)-3',11'-dichloro-4-methyl-6'-(methylamino)-2'-azaspiro[furan-2,7'-tricyclo[6.3.1.0⁴,¹²]dodecane]-1'(11'),3',8'(12'),9'-tetraen-5-one
(1s)-3-[(3r,4r)-3-ethenylpiperidin-4-yl]-1-(quinolin-4-yl)propan-1-ol
(3e)-6-methoxy-3-(3-methylbut-2-en-1-ylidene)indol-2-ol
1-(2-{[(2s)-2-[(2r)-2-carboxy-2-hydroxy-5-oxopyrrolidin-1-yl]-1-hydroxypropylidene]amino}ethyl)-2-hydroxypropane-1,2,3-tricarboxylic acid
(12z,25z,26e,28e)-5,21,33,36-tetrabromo-12,25-bis(hydroxyimino)-2,18-dioxa-10,27-diazapentacyclo[28.2.2.2¹⁴,¹⁷.1³,⁷.1¹⁹,²³]octatriaconta-1(32),3(38),4,6,10,14,16,19(35),20,22,26,28,30,33,36-pentadecaene-4,11,20,26-tetrol
(5s)-5-(3,5-dibromo-4-{[(5r)-2-hydroxy-4,5-dihydro-1,3-oxazol-5-yl]methoxy}phenyl)-4,5-dihydro-1,3-oxazol-2-ol
2h,5h,6h-[1,3]dioxolo[4,5-g]isoquinolin-5-yl(4-methoxyphenyl)methanol
(2r,3s)-n-(3-{[2-(2,4-dibromo-5-methoxyphenyl)ethyl](methyl)amino}propyl)-3-methyl-2-(methylamino)pentanimidic acid
methyl 10-hydroxy-2-oxa-9-azatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3(8),4,6,9,11,13-heptaene-7-carboxylate
3,6-diamino-n-{4-amino-5-[(4-amino-5-{[4-hydroxy-2-({7-hydroxy-5-methyl-4-oxo-3h,3ah,6h,7h,7ah-imidazo[4,5-c]pyridin-2-yl}amino)-5-(c-hydroxycarbonimidoyloxy)-6-(hydroxymethyl)oxan-3-yl]-c-hydroxycarbonimidoyl}pentyl)-c-hydroxycarbonimidoyl]pentyl}hexanimidic acid
2-{7-methyl-2h,3h-furo[3,2-h]isoquinolin-2-yl}propan-2-ol
n-{3-[(2s,5z)-5-[(3,5-dibromo-4-methoxyphenyl)methylidene]-4-hydroxy-2h-1,3-oxazol-2-yl]propyl}guanidine
10-amino-3-[10-amino-7-(3-hydroxypropyl)-11-oxo-2,7-diazatricyclo[6.3.1.0⁴,¹²]dodeca-1,3,5,8(12),9-pentaen-3-yl]-7-(3-hydroxypropyl)-2,7-diazatricyclo[6.3.1.0⁴,¹²]dodeca-1,3,5,8(12),9-pentaen-11-one
7-[(2,3-dibromo-4,5-dihydroxyphenyl)methyl]purine-2,6-diol
1-[(7s,7ar)-2-hydroxy-7-methyl-4h,5h,6h,7h,7ah-pyrrolo[3,2-b]pyridin-3-yl]ethanone
1-[2-(3,4-dimethoxyphenyl)-3-(2-oxo-5,6-dihydropyridine-1-carbonyl)-4-(3,4,5-trimethoxyphenyl)cyclobutanecarbonyl]-5,6-dihydropyridin-2-one
(3z,8as)-1-hydroxy-3-{[2-(2-methylbut-3-en-2-yl)-1h-indol-3-yl]methylidene}-6h,7h,8h,8ah-pyrrolo[1,2-a]pyrazin-4-one
(14s)-14-methoxy-8-oxa-17-azatetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-1(10),2,4,6,11(15),16-hexaen-4-ol
n-[4-({7,9-dibromo-10-hydroxy-8-methoxy-1-oxa-2-azaspiro[4.5]deca-2,6,8-trien-3-yl}formamido)-2-oxobutyl]methoxycarboximidic acid
[(1s,2s,3r,6r,10r,11s,12s)-7-(2h-1,3-benzodioxol-5-yl)-9-oxotetracyclo[8.2.1.0³,¹².0⁶,¹¹]trideca-4,7-dien-2-yl]acetic acid
(3s)-n-[(4s)-5-{[(2r,3r,4r,5s,6r)-2-{[(3as,7r,7as)-7-hydroxy-5-methyl-4-oxo-3h,3ah,6h,7h,7ah-imidazo[4,5-c]pyridin-2-yl]amino}-4-hydroxy-5-(c-hydroxycarbonimidoyloxy)-6-(hydroxymethyl)oxan-3-yl]-c-hydroxycarbonimidoyl}-4-aminopentyl]-3-amino-6-{[(3s)-3,6-diamino-1-hydroxyhexylidene]amino}hexanimidic acid
(5s)-5-[(1r,3r,4r,6s,7e,9s,14r,16s,17r,26s,29r)-6,29-dihydroxy-3,7,10,16,17,29-hexamethyl-24-methylidene-30,31-dioxa-19-azapentacyclo[24.3.1.1¹,⁴.0⁹,¹⁴.0¹⁴,²⁰]hentriaconta-7,10,19-trien-11-yl]-3-methyl-5h-furan-2-one
(3s)-1,4-dimethyl-3-({4-[(3-methylbut-2-en-1-yl)oxy]phenyl}methyl)-6-sulfanylidenepiperazine-2,5-dione
n-{2-[3,5-dibromo-4-(3-{[(5s,10r)-7,9-dibromo-10-hydroxy-8-methoxy-1-oxa-2-azaspiro[4.5]deca-2,6,8-trien-3-yl]formamido}propoxy)phenyl]-2-hydroxyethyl}ethanimidic acid
3',5'-dimethyl 5,9'-dichloro-4',13'-diazaspiro[indole-3,7'-tetracyclo[6.6.1.0²,⁶.0¹²,¹⁵]pentadecane]-1'(14'),2',5',8'(15'),9',11'-hexaene-3',5'-dicarboxylate
n-{4-methyl-5-oxo-[1,2]dithiolo[4,3-b]pyrrol-6-yl}propanimidic acid
(7e,9e)-10-chloro-2,2-dimethyl-5-methylidenedeca-7,9-dien-3-yl (2s)-1-methylpyrrolidine-2-carboxylate
2-hydroxy-6,7-dimethoxy-4-(4-methoxyphenyl)-1-methylnaphtho[2,3-d]imidazole-5,8-dione
(2e)-n-[(1s,2s,4s,5s,6s,7r,8s)-1,7-dihydroxy-5-methoxy-10-oxo-3-oxatricyclo[4.3.1.0²,⁴]decan-8-yl]dodec-2-enimidic acid
[(2r,3s,4s,5r,6s)-6-{[(2s,3r,4r,5r,6s)-2-{[(10r)-10-(acetyloxy)-3-hydroxy-8-[(2s)-2-methylbutanoyl]-1,4,8-triazacyclotridec-3-en-1-yl]oxy}-4,5-dihydroxy-6-methyloxan-3-yl]oxy}-3,4,5-trihydroxyoxan-2-yl]methyl (2e)-2-methylbut-2-enoate
Based on the functional groups mentioned in the compound's name, we can speculate about its possible biological functions: Hydroxyl group (-OH): The hydroxyl group is a polar functional group that can form hydrogen bonds, increasing the compound's water solubility. It may participate in nucleophilic attacks or act as a proton acceptor in enzyme-catalyzed reactions. In biological systems, hydroxyl groups may be involved in the metabolism of carbohydrates, lipids, and other molecules. Acetyloxy group (-OCOCH3): The acetyloxy group is an ester functional group that may increase the compound's lipid solubility. In biological systems, ester functional groups may serve as energy storage forms or participate in signal transduction. Triazacycle: Nitrogen atoms can form hydrogen bonds and participate in interactions with biological macromolecules such as proteins and nucleic acids. The triazacycle may possess basic properties, acting as a proton acceptor or donor in biological systems. It may have enzyme-inhibiting activity, involved in the regulation of enzyme activity within organisms. Methyl group (-CH3): The methyl group is a hydrophobic group that can affect the compound's lipid solubility and intermolecular interactions. In biological systems, methylation reactions are often associated with gene expression regulation, signal transduction, and other processes. Alkene bond (C=C): The alkene bond is a reactive site that may participate in electrophilic addition, cycloaddition, and other reactions. In biological systems, alkene bonds may be involved in redox reactions or serve as substrates for enzymes. Combining these functional groups, the possible biological functions of this compound include: Enzyme Inhibition: The triazacycle and hydroxyl groups may confer enzyme-inhibiting activity on the compound, involved in the regulation of metabolic pathways within organisms. Signal Transduction: The acetyloxy and methyl groups may enable the compound to participate in cellular signal transduction processes. Metabolic Regulation: The hydroxyl and alkene groups may involve the compound in the metabolism of carbohydrates, lipids, and other molecules. Molecular Recognition: The presence of both polar and non-polar groups may allow the compound to participate in interactions and recognition with biological macromolecules such as proteins and nucleic acids. Please note that these speculations are based on the common biological functions of the functional groups, and the actual situation may be more complex. Experimental validation is required to determine the specific biological functions of this compound.
