Streptozocin (BioDeep_00000006467)

 

Secondary id: BioDeep_00001867757

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


3-methyl-3-nitroso-1-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea

化学式: C8H15N3O7 (265.090996)
中文名称: 链脲菌素
谱图信息: 最多检出来源 Homo sapiens(blood) 31.25%

分子结构信息

SMILES: CN(C(=O)NC1C(C(C(OC1O)CO)O)O)N=O
InChI: InChI=1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)

描述信息

Streptozocin is only found in individuals that have used or taken this drug.It is an antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals. [PubChem]Although its mechanism of action is not completely clear, streptozocin is known to inhibit DNA synthesis, interfere with biochemical reactions of NAD and NADH, and inhibit some enzymes involved in gluconeogenesis. Its activity appears to occur as a result of formation of methylcarbonium ions, which alkylate or bind with many intracellular molecular structures including nucleic acids. Its cytotoxic action is probably due to cross-linking of strands of DNA, resulting in inhibition of DNA synthesis.
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01A - Alkylating agents > L01AD - Nitrosoureas
D000970 - Antineoplastic Agents

同义名列表

17 个代谢物同义名

3-methyl-3-nitroso-1-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea; 2-Deoxy-2-(((methylnitrosoamino)carbonyl)amino)-D-glucopyranose; 2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-glucose; 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose; N-D-Glucosyl-(2)-n'-nitrosomethylharnstoff; N-D-Glucosyl-(2)-n-nitrosomethylurea; Teva brand OF streptozocin; Streptozocin teva brand; Streptozotocin;U 9889; Streptozotocine; Streptozocinium; STREPTOZOTOCIN; Streptozocinum; Estreptozocina; Streptozocine; Streptozocin; Zanosar



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

7 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Vimi Kshetrimayum, Khaidem Devika Chanu, Thokchom Biona, Amit Kar, Pallab Kanti Haldar, Pulok K Mukherjee, Nanaocha Sharma. Paris polyphylla Sm. characterized extract infused ointment accelerates diabetic wound healing in In-vivo model. Journal of ethnopharmacology. 2024 Sep; 331(?):118296. doi: 10.1016/j.jep.2024.118296. [PMID: 38710458]
  • Haihui Jiang, Shibo Feng, Panpan Zhang, Jiaojiao Wang, Yi Jiang, Huawei Zhang, Xiaomei Song, Wenli Huang, Yundong Xie, Chong Deng. Petroleum ether extract of Schisandra sphenanthera prevents hyperglycemia and insulin resistance in association with modulation of sweet taste receptors and gut microbiota in T2DM rats. Journal of ethnopharmacology. 2024 Sep; 331(?):118300. doi: 10.1016/j.jep.2024.118300. [PMID: 38718889]
  • Aribam Indira, Babita Joshi, Ashwani Koul, Nirmala Chongtham. Comparative hepato-ameliorative effects of Bambusa nutans fresh and fermented shoot extracts on STZ induced diabetic LACA mice. Talanta. 2024 Jul; 274(?):126035. doi: 10.1016/j.talanta.2024.126035. [PMID: 38579421]
  • Silu Basumatary, Partha Pradip Adhikari, Ajit Kumar Das, Nanjian Raaman, Gauri Dutt Sharma, Jatin Sarmah, Anjum Dihingia, Rinku Baishya, Prasenjit Manna, Jatin Kalita. Antihyperglycemic and antihyperlipidemic effects of fruit extract of Hodgsonia heteroclita (Roxb.) Hook. f. & Thomson in diabetic mice. Journal of ethnopharmacology. 2024 Jun; 328(?):118094. doi: 10.1016/j.jep.2024.118094. [PMID: 38521433]
  • Nour Elhouda Daoudi, Soufiane El Assri, Mohammed Aziz, Mohammed Choukri, Hassane Mekhfi, Abdelkhaleq Legssyer, Abderrahim Ziyyat, Mohamed Bnouham. The effect of Argania spinosa seed oil on diabetic nephropathy in streptozotocin-induced diabetes in Wistar rats. Journal of ethnopharmacology. 2024 Jun; 328(?):118083. doi: 10.1016/j.jep.2024.118083. [PMID: 38521428]
  • Jie Lv, Meng Su, Yansong Wang, Juan Yang, Yanni Liang, Lin Chen, Liyan Lei. Yunvjian decoction mitigates hyperglycemia in rats induced by a high-fat diet and streptozotocin via reducing oxidative stress in pancreatic beta cells. Journal of ethnopharmacology. 2024 Jun; 327(?):118045. doi: 10.1016/j.jep.2024.118045. [PMID: 38479546]
  • Yanjun Wu, Jiayuan Mo, Jing Liang, Xiang Pu, Yuanqiu Dong, Xiang Zhu, Hai Zhao, Huaming Qiu, Shuguang Wu, Taofeng Lu. Multiomic study of the protective mechanism of Persicaria capitata (Buch.-Ham. ex D.Don) H.Gross against streptozotocin-induced diabetic nephropathy in Guizhou miniature pigs. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155499. doi: 10.1016/j.phymed.2024.155499. [PMID: 38492367]
  • Ebraheem Abouelwafa, Amal Zaki, Omar M Sabry, Riham A El-Shiekh, Giovanni Caprioli, Essam Abdel-Sattar. Unveiling the chemical profiling and remarkable modulation of carbohydrate metabolism by costus root, Dolomiaea costus (Falc.) in streptozotocin (STZ)-induced diabetic rats. Journal of ethnopharmacology. 2024 May; 326(?):117911. doi: 10.1016/j.jep.2024.117911. [PMID: 38355028]
  • Yangchen Tang, Mengli Yan, Zemin Fang, Song Jin, Tingjuan Xu. Effects of metformin, saxagliptin and repaglinide on gut microbiota in high-fat diet/streptozocin-induced type 2 diabetic mice. BMJ open diabetes research & care. 2024 May; 12(3):. doi: 10.1136/bmjdrc-2023-003837. [PMID: 38719505]
  • Nesma A Ghazal, Yara T Agamia, Basant K Meky, Nagwa M Assem, Wafaa M Abdel-Rehim, Sara A Shaker. Cinnamaldehyde ameliorates STZ-induced diabetes through modulation of autophagic process in adipocyte and hepatic tissues on rats. Scientific reports. 2024 05; 14(1):10053. doi: 10.1038/s41598-024-60150-2. [PMID: 38698047]
  • Mostafa Yousefian, Saeid Abedimanesh, Amirhossein Yadegar, Manouchehr Nakhjavani, S Zahra Bathaie. Co-administration of 'L-Lysine, Vitamin C, and Zinc' increased the antioxidant activity, decreased insulin resistance, and improved lipid profile in streptozotocin-induced diabetic rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 May; 174(?):116525. doi: 10.1016/j.biopha.2024.116525. [PMID: 38599057]
  • Mona Abd El-Mouty Raslan, Iman AbdelKhalek AbdelKhalek Kassem, Neveen Sabry Ghaly, May Aly El-Manawaty, Farouk Rasmy Melek, Marian Nabil. Aloe juvenna Brandham & S.Carter as α-Amylase Inhibitor and Hypoglycaemic Agent with Anti-inflammatory Properties for Diabetes Management. Chemistry & biodiversity. 2024 May; 21(5):e202400245. doi: 10.1002/cbdv.202400245. [PMID: 38436134]
  • Tushar Agarwal, Suman Manandhar, Harish Kumar B, Ademola C Famurewa, Prasada Chowdari Gurram, Ramya Shri Suggala, Runali Sankhe, Jayesh Mudgal, K Sreedhara Ranganath Pai. Oxyresveratrol-β-cyclodextrin mitigates streptozotocin-induced Alzheimer's model cognitive impairment, histone deacetylase activity in rats: in silico & in vivo studies. Scientific reports. 2024 04; 14(1):9897. doi: 10.1038/s41598-024-57188-7. [PMID: 38688962]
  • Paloma Lucía Guerra-Ávila, Tereso J Guzmán, Belinda Vargas-Guerrero, José Alfredo Domínguez-Rosales, Alejandra Beatriz Cervantes-Garduño, Adriana María Salazar-Montes, Laura Verónica Sánchez-Orozco, Carmen Magdalena Gurrola-Díaz. Comparative Screening of the Liver Gene Expression Profiles from Type 1 and Type 2 Diabetes Rat Models. International journal of molecular sciences. 2024 Apr; 25(8):. doi: 10.3390/ijms25084151. [PMID: 38673735]
  • C A Rosales-Gómez, B E Martínez-Carrillo, A L Guadarrama-López, A A Reséndiz-Albor, I M Arciniega-Martínez, E Aguilar-Rodríguez. Pharmacological induction of diabetes mellitus in pregnant female mice: a comparison of two doses and routes of administration. European review for medical and pharmacological sciences. 2024 Apr; 28(8):3275-3286. doi: 10.26355/eurrev_202404_36056. [PMID: 38708486]
  • Nasser A Alsabaani, Kawther Amawi, Samy M Eleawa, Wisam Nabeel Ibrahim, Walid Aldhaban, Ahmad Mohammad Alaraj, Badr Alkhalaf, Waqas Sami, Hisham Alshaikhli, Mahmoud A Alkhateeb. Nrf-2-dependent antioxidant and anti-inflammatory effects underlie the protective effect of esculeoside A against retinal damage in streptozotocin-induced diabetic rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Apr; 173(?):116461. doi: 10.1016/j.biopha.2024.116461. [PMID: 38503237]
  • Karuppannan P, Saravanan K, Ashokkumar M, Chukwuebuka Egbuna. Preparation of bio-synthesized Ag nanoparticles and assessment of their antidiabetic and antioxidant potential against STZ-induced diabetic albino rats. Journal of biomaterials science. Polymer edition. 2024 Apr; 35(4):535-558. doi: 10.1080/09205063.2024.2301808. [PMID: 38234041]
  • Shahinaz Ahmed Helmy, Nashwa Fathy Sayed Morsy, Shahenda Mohamed Elaby, Mohammed Abdel Hameed Awad Ghaly. Antidiabetic Effect of Combined Leaf Extracts of Portulaca oleracea L., Beta vulgaris L., and Cichorium intybus L. in Streptozotocin-Induced Diabetic Rats. Journal of medicinal food. 2024 Apr; 27(4):339-347. doi: 10.1089/jmf.2022.0119. [PMID: 37801671]
  • Afrooz Karimi, Farhad Kohpeyma, Ebrahim Asadi, Maryam Ziyaee, Samaneh Karimi. Protective efficacy of Nerium oleander extract on spermatogenesis in streptozotocin-induced diabetic rats. Zygote (Cambridge, England). 2024 Apr; 32(2):139-148. doi: 10.1017/s0967199423000643. [PMID: 38284273]
  • Gangqin Li, Lin Jiang, Kuan Bai, Guangxing Tan. MicroRNA-503-5p protects streptozotocin-induced erectile dysfunction in diabetic rats by downregulating SYDE2. Cellular and molecular biology (Noisy-le-Grand, France). 2024 Mar; 70(3):48-53. doi: 10.14715/cmb/2024.70.3.7. [PMID: 38650154]
  • Junpei Sanada, Tomohiko Kimura, Masashi Shimoda, Yuichiro Iwamoto, Hideyuki Iwamoto, Kazunori Dan, Yoshiro Fushimi, Yukino Katakura, Yuka Nogami, Yoshiko Shirakiya, Yuki Yamasaki, Tomoko Ikeda, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto. Protective effects of imeglimin on the development of atherosclerosis in ApoE KO mice treated with STZ. Cardiovascular diabetology. 2024 Mar; 23(1):105. doi: 10.1186/s12933-024-02189-z. [PMID: 38504316]
  • Saja Majeed Shareef, Raghad Abdulsalam Khaleel, Taif M Maryoosh. Nephroprotective effect of cranberry (Vaccinium oxycoccos) in streptozocin-induced diabetic nephropathy in mice. Drug metabolism and personalized therapy. 2024 Mar; 39(1):35-45. doi: 10.1515/dmpt-2023-0092. [PMID: 38469711]
  • Shimaa Alahmer, Mostafa El-Noss, Alyaa Farid. Preparation of chitosan nanoparticles loaded with Balanites aegyptiaca extract for treatment of streptozotocin-induced diabetes in rats. International journal of biological macromolecules. 2024 Mar; 262(Pt 2):130061. doi: 10.1016/j.ijbiomac.2024.130061. [PMID: 38336324]
  • Saad Fettach, Fatima Zahra Thari, Khalid Karrouchi, Laila Benbacer, Learn-Han Lee, Abdelhakim Bouyahya, Yahia Cherrah, Hassan Sefrioui, Khalid Bougrin, My El Abbes Faouzy. Assessment of anti-hyperglycemic and anti-hyperlipidemic effects of thiazolidine-2,4-dione derivatives in HFD-STZ diabetic animal model. Chemico-biological interactions. 2024 Mar; 391(?):110902. doi: 10.1016/j.cbi.2024.110902. [PMID: 38367680]
  • Ying Zhao, Jian- Wu Li. Quantification of mangiferin in streptozotocin-induced diabetic rat plasma using UPLC-MS/MS: Pharmacokinetic assessment of Gentiana rhodantha extract after oral administration. Pakistan journal of pharmaceutical sciences. 2024 Mar; 37(2):291-296. doi: ". [PMID: 38767095]
  • F M Kasali, J N Kadima, J B Safari, A G Agaba, J Tusiimire, B A Witika. Effects of Physalis peruviana L. (leaf crude extracts) on blood glucose and functional biomarkers in streptozotocin-nicotinamide-induced diabetic rats. Die Pharmazie. 2024 Feb; 79(1):6-10. doi: 10.1691/ph.2024.3640. [PMID: 38509628]
  • Laila Naif Al-Harbi, Ghedeir M Alshammari, Ghalia Shamlan, Manal Abdulaziz Binobead, Sahar Abdulaziz AlSedairy, Doha M Al-Nouri, Shaista Arzoo, Mohammed Abdo Yahya. Nephroprotective and Anti-Diabetic Potential of Beta vulgaris L. Root (Beetroot) Methanolic Extract in a Rat Model of Type 2 Diabetes Mellitus. Medicina (Kaunas, Lithuania). 2024 Feb; 60(3):. doi: 10.3390/medicina60030394. [PMID: 38541120]
  • Feyisayo O Adepoju, Ksenia V Sokolova, Irina F Gette, Irina G Danilova, Mikhail V Tsurkan, Alicia C Mondragon, Elena G Kovaleva, Jose Manuel Miranda. Protective Effect of Betulin on Streptozotocin-Nicotinamide-Induced Diabetes in Female Rats. International journal of molecular sciences. 2024 Feb; 25(4):. doi: 10.3390/ijms25042166. [PMID: 38396842]
  • Nurlaili Susanti, Arifa Mustika, Junaidi Khotib. Clinacanthus nutans leaf extract reduces pancreatic β-cell apoptosis by inhibiting JNK activation and modulating oxidative stress and inflammation in streptozotocin-induced diabetic rats. Open veterinary journal. 2024 Feb; 14(2):730-737. doi: 10.5455/ovj.2024.v14.i2.13. [PMID: 38549571]
  • Israt Jahan Bulbul, Md Jamal Hossain, Mohammad Rashedul Haque, Muhammad Abdullah Al-Mansur, Choudhury M Hasan, Abdullah Al Hasan, Mohammad A Rashid. Two rare flavonoid glycosides from Litsea glutinosa (Lour.) C. B. Rob.: experimental and computational approaches endorse antidiabetic potentiality. BMC complementary medicine and therapies. 2024 Feb; 24(1):69. doi: 10.1186/s12906-024-04337-0. [PMID: 38302935]
  • Mushuang Qi, Xiangka Hu, Wanjun Zhu, Ying Ren, Chunmei Dai. Study on effects and relevant mechanisms of Mudan granules on renal fibrosis in streptozotocin-induced diabetes rats. Renal failure. 2024 Jan; 46(1):2310733. doi: 10.1080/0886022x.2024.2310733. [PMID: 38357745]
  • Eman S Alamri, Haddad A El Rabey. The Protective Effects of Vanillic Acid and Vanillic Acid-Coated Silver Nanoparticles (AgNPs) in Streptozotocin-Induced Diabetic Rats. Journal of diabetes research. 2024; 2024(?):4873544. doi: 10.1155/2024/4873544. [PMID: 38577302]
  • Arifa Mehreen, Muhammad Anwar Iqbal, Zunaira Ashfaq, Rida Anwar, Mahwish Mahmood, Faisal Jameel, Muhammad Awais Khan. Effects of Cucumis melo and Citrullus lanatus extracts on glucose level, lipid profile and hepato-renal performance of streptozotocin-induced diabetic albino rats. Pakistan journal of pharmaceutical sciences. 2024 Jan; 37(1):71-78. doi: ". [PMID: 38741402]
  • Zeng Zhang, Xiaodong Fu, Fengzhu Zhou, Duanchun Zhang, Yanqiu Xu, Zhaohua Fan, Shimei Wen, Yanting Shao, Zheng Yao, Yanming He. Huaju Xiaoji Formula Regulates ERS-lncMGC/miRNA to Enhance the Renal Function of Hypertensive Diabetic Mice with Nephropathy. Journal of diabetes research. 2024; 2024(?):6942156. doi: 10.1155/2024/6942156. [PMID: 38282657]
  • Nural Pastacı Özsobacı, Metehan Karataş, Matem Tunçdemir, Derviş Özcelik. Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker on oxidative stress and metabolism of elements in kidney of STZ-induced diabetic rats. Archives of biochemistry and biophysics. 2024 Jan; 751(?):109851. doi: 10.1016/j.abb.2023.109851. [PMID: 38065251]
  • Guisheng Wang, Rongrong Hua, Xiaoxia Chen, Xucheng He, Yao Dingming, Hua Chen, Buhuan Zhang, Yuru Dong, Muqing Liu, Jiaxiong Liu, Ting Liu, Jingwei Zhao, Yu Qiong Zhao, Li Qiao. MX1 and UBE2L6 are potential metaflammation gene targets in both diabetes and atherosclerosis. PeerJ. 2024; 12(?):e16975. doi: 10.7717/peerj.16975. [PMID: 38406276]
  • Bo Jiang, Yan Jie Mou, Xian Mei Zhang, Kun Lu, Ping Xie, Yan Ling Rao, Ze Wei Cong, Qin Guo Sun. Ziyin Bushen Fang improves Diabetic Osteoporosis by Inhibiting Autophagy and Oxidative Stress In vitro and In vivo. Combinatorial chemistry & high throughput screening. 2024; 27(5):786-796. doi: 10.2174/0113862073261310231113062630. [PMID: 38773797]
  • Handan Mert, Nihan Mert, Salih Cibuk, Serkan Yildirim, Nihat Mert. Antidiabetic Effect of Fig Seed Oil in Rats with Diabetes Induced by Streptozotocin. Journal of oleo science. 2024; 73(5):717-727. doi: 10.5650/jos.ess23255. [PMID: 38692894]
  • Oluwafemi Adeleke Ojo, Akingbolabo Daniel Ogunlakin, Christopher Oloruntoba Akintayo, Olaoluwa Sesan Olukiran, Juliana Bunmi Adetunji, Omolola Adenike Ajayi-Odoko, Theophilus Oghenenyoreme Ogwa, Olorunfemi Raphael Molehin, Omolara Olajumoke Ojo, Ramzi A Mothana, Abdullah R Alanzi. Spilanthes filicaulis (Schumach. & Thonn.) C.D. Adams leaves protects against streptozotocin-induced diabetic nephropathy. PloS one. 2024; 19(4):e0301992. doi: 10.1371/journal.pone.0301992. [PMID: 38640098]
  • Yi Cui, Li Wang, Wentao Liang, Li Huang, Shuting Zhuang, Hong Shi, Nuo Xu, Jianzhang Hu. Identification and Validation of the Pyroptosis-Related Hub Gene Signature and the Associated Regulation Axis in Diabetic Keratopathy. Journal of diabetes research. 2024; 2024(?):2920694. doi: 10.1155/2024/2920694. [PMID: 38529047]
  • Venkata Krishna Karempudi, Tamilselvan Amutha Gokul, Kamatchi Ramesh Kumar, Veeramani Veeramanikandan, Daoud Ali, Federica Impellitteri, Caterina Faggio, Hammad Ullah, Maria Daglia, Paulraj Balaji. Protective role of Pleurotus florida against streptozotocin-induced hyperglycemia in rats: A preclinical study. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Jan; 170(?):116005. doi: 10.1016/j.biopha.2023.116005. [PMID: 38086150]
  • Narumi Takahashi, Osamu Ichii, Masaya Hiraishi, Takashi Namba, Yuki Otani, Teppei Nakamura, Yasuhiro Kon. Phenotypes of streptozotocin-induced gestational diabetes mellitus in mice. PloS one. 2024; 19(4):e0302041. doi: 10.1371/journal.pone.0302041. [PMID: 38626157]
  • Haiyan Chi, Yujing Sun, Peng Lin, Junyu Zhou, Jinbiao Zhang, Yachao Yang, Yun Qiao, Deshan Liu. Glucose Fluctuation Inhibits Nrf2 Signaling Pathway in Hippocampal Tissues and Exacerbates Cognitive Impairment in Streptozotocin-Induced Diabetic Rats. Journal of diabetes research. 2024; 2024(?):5584761. doi: 10.1155/2024/5584761. [PMID: 38282656]
  • Abdullah Khalid Alsulaim, Turki Hussain Almutaz, Abdulaziz Ahmed Albati, Arshad Husain Rahmani. Therapeutic Potential of Curcumin, a Bioactive Compound of Turmeric, in Prevention of Streptozotocin-Induced Diabetes through the Modulation of Oxidative Stress and Inflammation. Molecules (Basel, Switzerland). 2023 Dec; 29(1):. doi: 10.3390/molecules29010128. [PMID: 38202711]
  • Olakunle Sanni, Pilani Nkomozepi, Md Shahidul Islam. Ethyl Acetate Fractions of Tectona Grandis Crude Extract Modulate Glucose Absorption and Uptake as Well as Antihyperglycemic Potential in Fructose-Streptozotocin-Induced Diabetic Rats. International journal of molecular sciences. 2023 Dec; 25(1):. doi: 10.3390/ijms25010028. [PMID: 38203195]
  • Shing-Hwa Liu, Wan-Hsin Wu, Huei-Ping Tzeng, Wenchang Chiang, Meng-Tsan Chiang. Dehulled Adlay (Coix lachryma-jobi L.) ameliorates hepatic gluconeogenesis and steatosis in streptozotocin/high-fat diet-induced diabetic rats. Journal of food and drug analysis. 2023 Dec; 31(4):683-695. doi: 10.38212/2224-6614.3486. [PMID: 38526822]
  • Wensheng Wang, Lin Wang. Protective effect of tretinoin derivative and TXNRD1 protein on streptozotocin induced gestational diabetes via an age-rage signaling-pathway. Acta biochimica Polonica. 2023 Dec; 70(4):985-990. doi: 10.18388/abp.2020_6947. [PMID: 38060807]
  • Shuijing Wang, Liangkun Ma, Jing Ji, Ruichao Huo, Shan Dong, Yunfeng Bai, Linlin Hua, Jiao Lei, Sasa Tian, Manning Wang, Yan Yu. Protective effect of soy isolate protein against streptozotocin induced gestational diabetes mellitus via TLR4/MyD88/NF-κB signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Dec; 168(?):115688. doi: 10.1016/j.biopha.2023.115688. [PMID: 37890205]
  • H Alfheeaid, A Alhowail, F Ahmed, A Zaki, A Alkhaldy. Influence of various intermittent fasting regimens on body weight and glycemic control in streptozotocin-induced diabetic rats. European review for medical and pharmacological sciences. 2023 Dec; 27(23):11433-11444. doi: 10.26355/eurrev_202312_34582. [PMID: 38095391]
  • Arman Syah Goli, Vilasinee Hirunpanich Sato, Hitoshi Sato, Savita Chewchinda, Jiraporn Leanpolchareanchai, Jannarin Nontakham, Jantana Yahuafai, Thavaree Thilavech, Pongsatorn Meesawatsom, Metawee Maitree. Antihyperglycemic effects of Lysiphyllum strychnifolium leaf extract in vitro and in vivo. Pharmaceutical biology. 2023 Dec; 61(1):189-200. doi: 10.1080/13880209.2022.2160771. [PMID: 36625086]
  • Mahdieh Raeeszadeh, Borhan Shokrollahi, Abolfazl Akbari, Sima Masumi, Ali Akbar Amiri. Thyme extract could overcome diabetes-induced reproductive dysfunction by inhibiting oxidative damage and increasing the expression of insulin receptor substrate and pyruvate kinase in the rat sperm. The Journal of pharmacy and pharmacology. 2023 Nov; ?(?):. doi: 10.1093/jpp/rgad099. [PMID: 38007396]
  • Sai-Yang Xie, Shi-Qiang Liu, Tong Zhang, Wen-Ke Shi, Yun Xing, Wen-Xi Fang, Min Zhang, Meng-Ya Chen, Si-Chi Xu, Meng-Qi Fan, Lan-Lan Li, Heng Zhang, Nan Zhao, Zhao-Xiang Zeng, Si Chen, Xiao-Feng Zeng, Wei Deng, Qi-Zhu Tang. USP28 Serves as a Key Suppressor of Mitochondrial Morphofunctional Defects and Cardiac Dysfunction in the Diabetic Heart. Circulation. 2023 Nov; ?(?):. doi: 10.1161/circulationaha.123.065603. [PMID: 37994595]
  • Mehmet Salih Bakaç, Abdulahad Dogan, Mustafa Abdullah Yılmaz, Fikret Altındag, Fatih Donmez, Abdulhamit Battal. Ameliorative effects of Scutellaria Pinnatifida subsp. pichleri (Stapf) Rech.f. Extract in streptozotocin-induced diabetic rats: chemical composition, biochemical and histopathological evaluation. BMC complementary medicine and therapies. 2023 Nov; 23(1):410. doi: 10.1186/s12906-023-04252-w. [PMID: 37964249]
  • Min Luo, Zongren Hu, Ziyu Liu, Xiaoying Tian, Jisong Chen, Jichang Yang, Lumei Liu, Chengxiong Lin, Dian Li, Qinghu He. Methyl protodioscin reduces c-Myc to ameliorate diabetes mellitus erectile dysfunction via downregulation of AKAP12. Diabetes research and clinical practice. 2023 Nov; ?(?):111012. doi: 10.1016/j.diabres.2023.111012. [PMID: 37967586]
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