Lathosterol (BioDeep_00000636703)

Main id: BioDeep_00000004609

 

PANOMIX_OTCML-2023


代谢物信息卡片


(3S,5S,9R,10S,13R,14R,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol

化学式: C27H46O (386.3548466)
中文名称: 5α-胆固醇-7-烯-3ß-醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1[C@]2(C)[C@@]3([H])CC[C@]4(C)[C@@]([H])([C@]([H])(C)CCCC(C)C)CC[C@@]4([H])C3=CC[C@@]2([H])C[C@@H](O)C1
InChI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1

描述信息

Lathosterol is a cholesterol-like molecule. Serum Lathosterol concentration is an indicator of whole-body cholesterol synthesis.
Lathosterol is a cholesterol-like molecule. Serum Lathosterol concentration is an indicator of whole-body cholesterol synthesis.

同义名列表

17 个代谢物同义名

Lathosterol; (3S,5S,9R,10S,13R,14R,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol; (3S,5S,9R,10S,13R,14R,17R)-17-[(1R)-1,5-dimethylhexyl]-10,13-dimethyl-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol; Cholest-7-en-3-ol, (3-beta,5-alpha)- (9CI); (3-beta,5-alpha)-Cholest-7-en-3-ol; 5-alpha-Cholest-7-en-3-beta-ol; 5alpha-Cholest-7-en-3beta-ol; delta(sup 7)-Cholestenol; 7-Cholesten-3-beta-ol; cholest-7-en-3beta-ol; Cholesterin [German]; gamma-Cholesterol; LMST01010089; CHEBI:17168; ST5331314; C01189; ST 27:1;O



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(3)

PlantCyc(3)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

75 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Valéria Sutti Nunes, Angela de Oliveira Godoy Ilha, Guilherme da Silva Ferreira, Renata de Paula Assis Bombo, Milessa Silva Afonso, Maria Silvia Ferrari Lavrador, Roberta Marcondes Machado, Edna Regina Nakandakare, Eder Carlos Rocha Quintão, Ana Maria Lottenberg. Plasma lathosterol measures rates of cholesterol synthesis and efficiency of dietary phytosterols in reducing the plasma cholesterol concentration. Clinics (Sao Paulo, Brazil). 2022; 77(?):100028. doi: 10.1016/j.clinsp.2022.100028. [PMID: 35397367]
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  • Min-Ji Oh, Hee-Jin So, Eun-Sik Hong, Jung-Ah Shin, Ki-Teak Lee. Presence of Cholesterol in Non-Animal Organisms: Identification and Quantification of Cholesterol in Crude Seed Oil from Perilla frutescens and Dehydrated Pyropia tenera. Molecules (Basel, Switzerland). 2021 Jun; 26(12):. doi: 10.3390/molecules26123767. [PMID: 34205624]
  • Wen-Chin Lee, Wei-Hung Kuo, Sin-Hua Moi, Barry Chiu, Jin-Bor Chen, Cheng-Hong Yang. Associations between Circulating Markers of Cholesterol Homeostasis and Macrovascular Events among Patients Undergoing Hemodialysis. Nutrients. 2021 Mar; 13(3):. doi: 10.3390/nu13031014. [PMID: 33801029]
  • Ivana Semova, Amy E Levenson, Joanna Krawczyk, Kevin Bullock, Kathryn A Williams, R Paul Wadwa, Philip R Khoury, Thomas R Kimball, Elaine M Urbina, Sarah D de Ferranti, David M Maahs, Lawrence M Dolan, Amy S Shah, Clary B Clish, Sudha B Biddinger. Markers of cholesterol synthesis are elevated in adolescents and young adults with type 2 diabetes. Pediatric diabetes. 2020 11; 21(7):1126-1131. doi: 10.1111/pedi.13097. [PMID: 32738021]
  • Valéria Sutti Nunes, Isabela M Bensenor, Paulo A Lotufo, Marisa Passarelli, Edna Regina Nakandakare, Eder Carlos Rocha Quintão. The coronary artery calcium score is linked to plasma cholesterol synthesis and absorption markers: Brazilian Longitudinal Study of Adult Health. Bioscience reports. 2020 07; 40(7):. doi: 10.1042/bsr20201094. [PMID: 32579186]
  • Hiroshi Yoshida, Hayato Tada, Kumie Ito, Yoshimi Kishimoto, Hidekatsu Yanai, Tomonori Okamura, Katsunori Ikewaki, Kyoko Inagaki, Tetsuo Shoji, Hideaki Bujo, Takashi Miida, Masayuki Yoshida, Masafumi Kuzuya, Shizuya Yamashita. Reference Intervals of Serum Non-Cholesterol Sterols by Gender in Healthy Japanese Individuals. Journal of atherosclerosis and thrombosis. 2020 May; 27(5):409-417. doi: 10.5551/jat.50187. [PMID: 31484845]
  • Hammad Ullah, Ajmal Khan, Najeeb Ur Rehman, Sobia Ahsan Halim, Haroon Khan, Imran Khan, Rene Csuk, Ahmed Al-Rawahi, Saif Al-Hatmi, Ahmed Al-Harrasi. Lophenol and lathosterol from resin of Commiphora kua possess hepatoprotective effects in vivo. Journal of ethnopharmacology. 2020 Apr; 252(?):112558. doi: 10.1016/j.jep.2020.112558. [PMID: 31926985]
  • Monica Gelzo, Maria Donata Di Taranto, Concetta Sica, Antonio Boscia, Francesco Papagni, Giuliana Fortunato, Gaetano Corso, Antonio Dello Russo. Age-related changes of cholestanol and lathosterol plasma concentrations: an explorative study. Lipids in health and disease. 2019 Dec; 18(1):235. doi: 10.1186/s12944-019-1176-3. [PMID: 31888647]
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  • Satoshi Hirayama, Hironori Nagasaka, Akira Honda, Haruki Komatsu, Takahiro Kodama, Ayano Inui, Ichiro Morioka, Shunsaku Kaji, Tsuyoshi Ueno, Kenji Ihara, Mariko Yagi, Zenro Kizaki, Kazuhiko Bessho, Hiroki Kondou, Tohru Yorifuji, Hirokazu Tsukahara, Kazumoto Iijima, Takashi Miida. Cholesterol Metabolism Is Enhanced in the Liver and Brain of Children With Citrin Deficiency. The Journal of clinical endocrinology and metabolism. 2018 07; 103(7):2488-2497. doi: 10.1210/jc.2017-02664. [PMID: 29659898]
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  • Rgia A Othman, Semone B Myrie, David Mymin, Jean-Baptiste Roullet, Andrea E DeBarber, Robert D Steiner, Peter J H Jones. Thyroid Hormone Status in Sitosterolemia Is Modified by Ezetimibe. The Journal of pediatrics. 2017 09; 188(?):198-204.e1. doi: 10.1016/j.jpeds.2017.05.049. [PMID: 28625503]
  • Marcella Matos Cordeiro Borges, Hanna Leijoto de Oliveira, Keyller Bastos Borges. Molecularly imprinted solid-phase extraction coupled with LC-APCI-MS-MS for the selective determination of serum cholesterol. Electrophoresis. 2017 09; 38(17):2150-2159. doi: 10.1002/elps.201600489. [PMID: 28543542]
  • Akinori Sawamura, Takahiro Okumura, Hiroaki Hiraiwa, Soichiro Aoki, Toru Kondo, Takeo Ichii, Kenji Furusawa, Naoki Watanabe, Naoaki Kano, Kenji Fukaya, Ryota Morimoto, Yasuko K Bando, Toyoaki Murohara. Cholesterol metabolism as a prognostic marker in patients with mildly symptomatic nonischemic dilated cardiomyopathy. Journal of cardiology. 2017 Jun; 69(6):888-894. doi: 10.1016/j.jjcc.2016.08.012. [PMID: 27686044]
  • Frans Stellaard, Klaus von Bergmann, Thomas Sudhop, Dieter Lütjohann. The value of surrogate markers to monitor cholesterol absorption, synthesis and bioconversion to bile acids under lipid lowering therapies. The Journal of steroid biochemistry and molecular biology. 2017 05; 169(?):111-122. doi: 10.1016/j.jsbmb.2016.03.030. [PMID: 27060336]
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  • Eva Herzog, Ingo Pragst, Marcel Waelchli, Andreas Gille, Sabrina Schenk, Jochen Mueller-Cohrs, Svetlana Diditchenko, Paolo Zanoni, Marina Cuchel, Andreas Seubert, Daniel J Rader, Samuel D Wright. Reconstituted high-density lipoprotein can elevate plasma alanine aminotransferase by transient depletion of hepatic cholesterol: role of the phospholipid component. Journal of applied toxicology : JAT. 2016 08; 36(8):1038-47. doi: 10.1002/jat.3264. [PMID: 26651060]
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  • Wendy Whiteside, Meng Tan, Richard E Ostlund, Sunkyung Yu, Lina Ma, Albert Rocchini. Altered Cholesterol Metabolism and Hypocholesterolemia in Patients with Single Ventricle following Fontan Palliation. The Journal of pediatrics. 2016 Apr; 171(?):73-7. doi: 10.1016/j.jpeds.2015.12.038. [PMID: 26806364]
  • R T Ras, W P Koppenol, U Garczarek, A Otten-Hofman, D Fuchs, F Wagner, E A Trautwein. Increases in plasma plant sterols stabilize within four weeks of plant sterol intake and are independent of cholesterol metabolism. Nutrition, metabolism, and cardiovascular diseases : NMCD. 2016 Apr; 26(4):302-9. doi: 10.1016/j.numecd.2015.11.007. [PMID: 26806045]
  • Isabel Andrade, Lèlita Santos, Fernando Ramos. Cholesterol absorption and synthesis markers in Portuguese hypercholesterolemic adults: A cross-sectional study. European journal of internal medicine. 2016 Mar; 28(?):85-90. doi: 10.1016/j.ejim.2015.10.022. [PMID: 26577223]
  • Andrea Mignarri, Alessandro Magni, Marina Del Puppo, Gian Nicola Gallus, Ingemar Björkhem, Antonio Federico, Maria Teresa Dotti. Evaluation of cholesterol metabolism in cerebrotendinous xanthomatosis. Journal of inherited metabolic disease. 2016 Jan; 39(1):75-83. doi: 10.1007/s10545-015-9873-1. [PMID: 26153518]
  • Dylan S MacKay, Peter K Eck, Sarah K Gebauer, David J Baer, Peter Jh Jones. CYP7A1-rs3808607 and APOE isoform associate with LDL cholesterol lowering after plant sterol consumption in a randomized clinical trial. The American journal of clinical nutrition. 2015 Oct; 102(4):951-7. doi: 10.3945/ajcn.115.109231. [PMID: 26333513]
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