ent-8(14),15-Pimaradiene (BioDeep_00000006057)

 

Secondary id: BioDeep_00001869622

human metabolite Endogenous natural product


代谢物信息卡片


7-ethenyl-1,1,4a,7-tetramethyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydrophenanthrene

化学式: C20H32 (272.2504)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(plant) 12.12%

分子结构信息

SMILES: C=CC1(C)C=C2CCC3C(C)(C)CCCC3(C)C2CC1
InChI: InChI=1S/C20H32/c1-6-19(4)13-10-16-15(14-19)8-9-17-18(2,3)11-7-12-20(16,17)5/h6,14,16-17H,1,7-13H2,2-5H3

描述信息

ent-8(14),15-Pimaradiene is found in fruits. ent-8(14),15-Pimaradiene is a constituent of Aralia racemosa (American spikenard).
Constituent of Aralia racemosa (American spikenard). ent-8(14),15-Pimaradiene is found in fruits.

同义名列表

6 个代谢物同义名

7-ethenyl-1,1,4a,7-tetramethyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydrophenanthrene; 7-ethenyl-1,1,4a,7-tetramethyl-3,4,4b,5,6,9,10,10a-octahydro-2H-phenanthrene; ent-8(14),15-Pimaradiene; Pimara-8(14),15-diene; 13-Isopimaradiene; Pimaradiene



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

103 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 AIMP2, FPR1, NFKB1, NR1H2, PPARG, PRKAA2, PTGS2, SIRT1, SREBF1, TLR4
Peripheral membrane protein 1 PTGS2
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 2 PTGS2, SREBF1
Nucleus 10 AIMP2, MPO, NFKB1, NR1H2, NR1H4, PPARA, PPARG, PRKAA2, SIRT1, SREBF1
cytosol 8 AIMP2, GPT, NFKB1, NR1H2, PPARG, PRKAA2, SIRT1, SREBF1
dendrite 1 PRKAA2
nucleoplasm 9 MPO, NFKB1, NR1H2, NR1H4, PPARA, PPARG, PRKAA2, SIRT1, SREBF1
RNA polymerase II transcription regulator complex 3 NR1H2, NR1H4, PPARG
Cell membrane 4 FPR1, SELE, TLR4, TNF
Multi-pass membrane protein 2 FPR1, SREBF1
Golgi apparatus membrane 1 SREBF1
cell surface 3 HBEGF, TLR4, TNF
Golgi apparatus 1 PRKAA2
Golgi membrane 1 SREBF1
lysosomal membrane 1 GAA
neuronal cell body 2 PRKAA2, TNF
Cytoplasm, cytosol 1 AIMP2
Lysosome 2 GAA, MPO
plasma membrane 6 FPR1, GAA, HBEGF, SELE, TLR4, TNF
Membrane 5 AIMP2, FPR1, GAA, PRKAA2, TLR4
axon 1 PRKAA2
caveola 2 PTGS2, SELE
extracellular exosome 3 GAA, GPT, MPO
Lysosome membrane 1 GAA
endoplasmic reticulum 2 PTGS2, SREBF1
extracellular space 6 CXCL8, HBEGF, IL6, MPO, SELE, TNF
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 3 PPARG, SELE, TLR4
mitochondrion 2 NFKB1, SIRT1
protein-containing complex 2 PTGS2, SREBF1
intracellular membrane-bounded organelle 3 GAA, MPO, PPARG
Microsome membrane 1 PTGS2
chromatin silencing complex 1 SIRT1
Single-pass type I membrane protein 2 SELE, TLR4
Secreted 3 CXCL8, GAA, IL6
extracellular region 7 CXCL8, GAA, HBEGF, IL6, MPO, NFKB1, TNF
transcription regulator complex 1 NFKB1
external side of plasma membrane 3 SELE, TLR4, TNF
nucleolus 1 SIRT1
Early endosome 1 TLR4
clathrin-coated pit 1 SELE
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
heterochromatin 1 SIRT1
Membrane raft 2 SELE, TNF
Nucleus, PML body 1 SIRT1
PML body 1 SIRT1
secretory granule 1 MPO
nuclear speck 1 PRKAA2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 2 PTGS2, SIRT1
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 3 NR1H4, PPARG, TLR4
neuron projection 1 PTGS2
chromatin 7 NFKB1, NR1H2, NR1H4, PPARA, PPARG, SIRT1, SREBF1
phagocytic cup 2 TLR4, TNF
[Isoform 3]: Nucleus 1 NR1H4
fibrillar center 1 SIRT1
nuclear envelope 2 SIRT1, SREBF1
Cytoplasmic vesicle membrane 1 SREBF1
tertiary granule membrane 1 GAA
cytoplasmic stress granule 1 PRKAA2
euchromatin 2 NR1H4, SIRT1
azurophil granule 1 MPO
lipopolysaccharide receptor complex 1 TLR4
secretory granule lumen 1 NFKB1
secretory granule membrane 1 FPR1
endoplasmic reticulum lumen 2 IL6, PTGS2
specific granule lumen 1 NFKB1
endocytic vesicle membrane 1 HBEGF
azurophil granule membrane 2 FPR1, GAA
azurophil granule lumen 1 MPO
ER to Golgi transport vesicle membrane 1 SREBF1
clathrin-coated endocytic vesicle membrane 1 HBEGF
phagocytic vesicle lumen 1 MPO
[Isoform 2]: Nucleus 1 NR1H4
[Isoform 1]: Nucleus 1 NR1H4
ficolin-1-rich granule membrane 2 FPR1, GAA
eNoSc complex 1 SIRT1
rDNA heterochromatin 1 SIRT1
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
nucleotide-activated protein kinase complex 1 PRKAA2
Cytoplasmic vesicle, COPII-coated vesicle membrane 1 SREBF1
[Isoform 4]: Nucleus 1 NR1H4
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cortical cytoskeleton 1 SELE
interleukin-6 receptor complex 1 IL6
autolysosome lumen 1 GAA
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
[Sterol regulatory element-binding protein 1]: Endoplasmic reticulum membrane 1 SREBF1
[Processed sterol regulatory element-binding protein 1]: Nucleus 1 SREBF1
[Isoform SREBP-1aDelta]: Nucleus 1 SREBF1
[Isoform SREBP-1cDelta]: Nucleus 1 SREBF1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[SirtT1 75 kDa fragment]: Cytoplasm 1 SIRT1


文献列表

  • Dawn E Hall, Philipp Zerbe, Sharon Jancsik, Alfonso Lara Quesada, Harpreet Dullat, Lina L Madilao, Macaire Yuen, Jörg Bohlmann. Evolution of conifer diterpene synthases: diterpene resin acid biosynthesis in lodgepole pine and jack pine involves monofunctional and bifunctional diterpene synthases. Plant physiology. 2013 Feb; 161(2):600-16. doi: 10.1104/pp.112.208546. [PMID: 23370714]
  • Christopher I Keeling, Sabrina Weisshaar, Steven G Ralph, Sharon Jancsik, Britta Hamberger, Harpreet K Dullat, Jörg Bohlmann. Transcriptome mining, functional characterization, and phylogeny of a large terpene synthase gene family in spruce (Picea spp.). BMC plant biology. 2011 Mar; 11(?):43. doi: 10.1186/1471-2229-11-43. [PMID: 21385377]
  • Dana Morrone, Meimei Xu, D Bruce Fulton, Mara K Determan, Reuben J Peters. Increasing complexity of a diterpene synthase reaction with a single residue switch. Journal of the American Chemical Society. 2008 Apr; 130(16):5400-1. doi: 10.1021/ja710524w. [PMID: 18366162]
  • Yung-Jin Chang, Bo-Ra Kim, Soo-Un Kim. Metabolic flux analysis of diterpene biosynthesis pathway in rice. Biotechnology letters. 2005 Sep; 27(18):1375-80. doi: 10.1007/s10529-005-3684-7. [PMID: 16215852]
  • Matthew M Ravn, Reuben J Peters, Robert M Coates, Rodney Croteau. Mechanism of abietadiene synthase catalysis: stereochemistry and stabilization of the cryptic pimarenyl carbocation intermediates. Journal of the American Chemical Society. 2002 Jun; 124(24):6998-7006. doi: 10.1021/ja017734b. [PMID: 12059223]