Ritalin (BioDeep_00000408851)
Main id: BioDeep_00000002043
代谢物信息卡片
methylphenidate
化学式: C14H19NO2 (233.1416)
中文名称: 匹普鲁多, 哌醋甲酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC(=O)C(C(C2)NCCC2)c(c1)cccc1
InChI: InChI=1S/C14H19NO2/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3
描述信息
N - Nervous system > N06 - Psychoanaleptics > N06B - Psychostimulants, agents used for adhd and nootropics > N06BA - Centrally acting sympathomimetics
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018765 - Dopamine Uptake Inhibitors
D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants
C78272 - Agent Affecting Nervous System > C47795 - CNS Stimulant
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents
D049990 - Membrane Transport Modulators
同义名列表
4 个代谢物同义名
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:84276
- ChEBI: CHEBI:6887
- KEGG: C07196
- KEGGdrug: D04999
- PubChem: 4158
- DrugBank: DB00422
- ChEMBL: CHEMBL796
- MeSH: Methylphenidate
- CAS: 113-45-1
- MoNA: WA001252
- MoNA: WA001251
- MoNA: WA001250
- MoNA: WA001249
- MoNA: WA001248
- PubChem: 9405
- NIKKAJI: J5.133K
- KNApSAcK: 6887
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Susu Qu, Xiangyu Zhou, Zhicheng Wang, Yi Wei, Han Zhou, Xinshuang Zhang, Qingjie Zhu, Yanmin Wang, Quanjun Yang, Likun Jiang, Yuan Ma, Yuan Gao, Lei Kong, Li Zhang. The effects of methylphenidate and atomoxetine on Drosophila brain at single-cell resolution and potential drug repurposing for ADHD treatment.
Molecular psychiatry.
2023 Nov; ?(?):. doi:
10.1038/s41380-023-02314-6. [PMID: 37957291] - Franziska Huber, Jan Schulz, Robert Schlack, Heike Hölling, Ulrike Ravens-Sieberer, Thomas Meyer, Aribert Rothenberger, Biyao Wang, Andreas Becker. Long-term changes in serum levels of lipoproteins in children and adolescents with attention-deficit/hyperactivity disorder (ADHD).
Journal of neural transmission (Vienna, Austria : 1996).
2023 04; 130(4):597-609. doi:
10.1007/s00702-022-02583-5. [PMID: 36826608] - Nilifer Gürbüzer, Hacer Akgül Ceyhun, Nurinnisa Öztürk, Kamber Kasali. The Relationship Between Eating-Attitudes and Clinical Characteristics, Agouti-Related Peptide, and Other Biochemical Markers in Adult-Attention Deficit Hyperactivity Disorder.
Journal of attention disorders.
2023 02; 27(4):394-409. doi:
10.1177/10870547221149198. [PMID: 36642920] - Jing Wang, Xin-Qiang Ni, Li-Min Li, Ying-Zhao Liao, Yao Chen, Chun-Ling Huang. [Effect of Rehmanniae Radix Praeparata on energy metabolism in prefrontal cortex of rats with attention deficit hyperactivity disorder based on "static Yin and dynamic Yang" theory].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Jul; 47(13):3554-3561. doi:
10.19540/j.cnki.cjcmm.20220412.402. [PMID: 35850809] - Javier Quintero, Alberto Rodríguez-Quiroga, Miguel Ángel Álvarez-Mon, Fernando Mora, Anthony L Rostain. Addressing the Treatment and Service Needs of Young Adults with Attention Deficit Hyperactivity Disorder.
Child and adolescent psychiatric clinics of North America.
2022 Jul; 31(3):531-551. doi:
10.1016/j.chc.2022.03.007. [PMID: 35697400] - Liang-Jen Wang, Ying-Hua Huang, Wen-Jiun Chou, Sheng-Yu Lee. Growth Hormone and Thyroid Function in Children With Attention Deficit Hyperactivity Disorder Undergoing Drug Therapy.
The Journal of clinical endocrinology and metabolism.
2022 06; 107(7):2047-2056. doi:
10.1210/clinem/dgac139. [PMID: 35262170] - Rene Braeckman, Sven Guenther, Travis C Mickle, Andrew C Barrett, Adam Smith, Charles Oh. Dose Proportionality and Steady-State Pharmacokinetics of Serdexmethylphenidate/Dexmethylphenidate, a Novel Prodrug Combination to Treat Attention-Deficit/Hyperactivity Disorder.
Journal of child and adolescent psychopharmacology.
2022 Jun; 32(5):288-295. doi:
10.1089/cap.2022.0015. [PMID: 35666231] - Majid Motaghinejad, Manijeh Motevalian. Neuroprotective Properties of Minocycline Against Methylphenidate-Induced Neurodegeneration: Possible Role of CREB/BDNF and Akt/GSK3 Signaling Pathways in Rat Hippocampus.
Neurotoxicity research.
2022 Jun; 40(3):689-713. doi:
10.1007/s12640-021-00454-7. [PMID: 35446003] - Michel Arvidsson, Johan Franck, Gerd Ackehed, Madeleine Pettersson Bergstrand, Lena Ekström, Staffan Rosenborg, Marja-Liisa Dahl. Plasma concentrations of methylphenidate enantiomers in adults with ADHD and substance use disorder, with focus on high doses and relationship to carboxylesterase activity.
Basic & clinical pharmacology & toxicology.
2022 Apr; 130(4):492-500. doi:
10.1111/bcpt.13707. [PMID: 35040257] - Jian Shi, Jingcheng Xiao, Xinwen Wang, Sun Min Jung, Barry E Bleske, John S Markowitz, Kennerly S Patrick, Hao-Jie Zhu. Plasma Carboxylesterase 1 Predicts Methylphenidate Exposure: A Proof-of-Concept Study Using Plasma Protein Biomarker for Hepatic Drug Metabolism.
Clinical pharmacology and therapeutics.
2022 04; 111(4):878-885. doi:
10.1002/cpt.2486. [PMID: 34743324] - Vincent Chin-Hung Chen, Yao-Hsu Yang, Charles Tzu-Chi Lee, Yi-Lung Chen, Michael E Dewey, Michael Gossop. Methylphenidate and TBI in ADHD and co-occurring epilepsy and mental disorders: a self-controlled case series study.
European child & adolescent psychiatry.
2022 Feb; 31(2):361-368. doi:
10.1007/s00787-020-01694-2. [PMID: 33389157] - Peter Manza, Ehsan Shokri-Kojori, Corinde E Wiers, Danielle Kroll, Dana Feldman, Katherine McPherson, Erin Biesecker, Evan Dennis, Allison Johnson, Andrew Kelleher, Song Qu, Dardo Tomasi, Gene-Jack Wang, Nora D Volkow. Sex differences in methylphenidate-induced dopamine increases in ventral striatum.
Molecular psychiatry.
2022 02; 27(2):939-946. doi:
10.1038/s41380-021-01294-9. [PMID: 34707237] - Peter Manu. Repurposing Drugs for Post-COVID-19 Fatigue Syndrome: Methylphenidate, Duloxetine, and Brexpiprazole.
American journal of therapeutics.
2022 01; 29(2):e229-e230. doi:
10.1097/mjt.0000000000001471. [PMID: 35389574] - Francesco Traccis, Riccardo Presciuttini, Pier Paolo Pani, Julia M A Sinclair, Lorenzo Leggio, Roberta Agabio. Alcohol-medication interactions: A systematic review and meta-analysis of placebo-controlled trials.
Neuroscience and biobehavioral reviews.
2022 01; 132(?):519-541. doi:
10.1016/j.neubiorev.2021.11.019. [PMID: 34826511] - Danfeng Yuan, Manxue Zhang, Yan Huang, Xinwei Wang, Jian Jiao, Yi Huang. Noradrenergic genes polymorphisms and response to methylphenidate in children with ADHD: A systematic review and meta-analysis.
Medicine.
2021 Nov; 100(46):e27858. doi:
10.1097/md.0000000000027858. [PMID: 34797323] - X Zhang, J Talpos, M S Berridge, S M Apana, W Slikker, C Wang, M G Paule. MicroPET/CT assessment of neurochemical effects in the brain after long-term methylphenidate treatment in nonhuman primates.
Neurotoxicology and teratology.
2021 Sep; 87(?):107017. doi:
10.1016/j.ntt.2021.107017. [PMID: 34265415] - Antonio Molina-Carballo, Isabel Cubero-Millán, Luisa Fernández-López, Ana Checa-Ros, Irene Machado-Casas, Antonio Jerez-Calero, Enrique Blanca-Jover, Antonio-Manuel Cantarero-Malagón, José Uberos, Antonio Muñoz-Hoyos. Methylphenidate ameliorates the homeostatic balance between levels of kynurenines in ADHD children.
Psychiatry research.
2021 09; 303(?):114060. doi:
10.1016/j.psychres.2021.114060. [PMID: 34175711] - Hang Thi Nguyet Pham, Hong Nguyen Tran, Xoan Thi Le, Ha Thi Do, Tue Trong Nguyen, Chien Le Nguyen, Hideki Yoshida, Masamistu Yamaguchi, Folk R William, Kinzo Matsumoto. Ilex kudingcha C.J. Tseng Mitigates Phenotypic Characteristics of Human Autism Spectrum Disorders in a Drosophila Melanogaster Rugose Mutant.
Neurochemical research.
2021 Aug; 46(8):1995-2007. doi:
10.1007/s11064-021-03337-7. [PMID: 33950474] - Ping Zhou, Mark Lee Wolraich, Ai-Hua Cao, Fei-Yong Jia, Bin Liu, Lin Zhu, Yongfang Liu, Xiaoli Li, Chao Li, Bin Peng, Ting Yang, Jie Chen, Qian Cheng, Tingyu Li, Li Chen. Adjuvant effects of vitamin A and vitamin D supplementation on treatment of children with attention-deficit/hyperactivity disorder: a study protocol for a randomised, double-blinded, placebo-controlled, multicentric trial in China.
BMJ open.
2021 06; 11(6):e050541. doi:
10.1136/bmjopen-2021-050541. [PMID: 34135055] - Satoru Aoki, Asuka Kaizaki-Mitsumoto, Natsumi Hattori, Satoshi Numazawa. Fetal methylphenidate exposure induced ADHD-like phenotypes and decreased Drd2 and Slc6a3 expression levels in mouse offspring.
Toxicology letters.
2021 Jun; 344(?):1-10. doi:
10.1016/j.toxlet.2021.02.016. [PMID: 33647392] - Liang-Jen Wang, Ying-Hua Huang, Wen-Jiun Chou, Sheng-Yu Lee, Ching-Shu Tsai, Min-Jing Lee, Miao-Chun Chou. Potential disturbance of methylphenidate of gonadal hormones or pubescent development in patients with attention-deficit/hyperactivity disorder: A twelve-month follow-up study.
Progress in neuro-psychopharmacology & biological psychiatry.
2021 06; 108(?):110181. doi:
10.1016/j.pnpbp.2020.110181. [PMID: 33227299] - Sarah L Belsey, Robert J Flanagan. Analytical Detection of Novel Stimulants by Immunoassay and Liquid Chromatography-High Resolution Mass Spectrometry: Case Studies on Ethylphenidate and Mephedrone.
Journal of analytical toxicology.
2021 May; 45(5):521-528. doi:
10.1093/jat/bkaa102. [PMID: 32816012] - Natália Freddo, Suelen Mendonça Soares, Milena Fortuna, Aline Pompermaier, Amanda Carolina Cole Varela, Victoria Costa Maffi, Mateus Timbola Mozzato, Heloísa Helena de Alcantara Barcellos, Gessi Koakoski, Leonardo José Gil Barcellos, Luciana Grazziotin Rossato-Grando. Stimulants cocktail: Methylphenidate plus caffeine impairs memory and cognition and alters mitochondrial and oxidative status.
Progress in neuro-psychopharmacology & biological psychiatry.
2021 03; 106(?):110069. doi:
10.1016/j.pnpbp.2020.110069. [PMID: 32800866] - Yi-Chun Liu, Vincent Chin-Hung Chen, Yao-Hsu Yang, Yi-Lung Chen, Michael Gossop. Association of psychiatric comorbidities with the risk of transport accidents in ADHD and MPH.
Epidemiology and psychiatric sciences.
2021 Feb; 30(?):e14. doi:
10.1017/s2045796021000032. [PMID: 33583471] - Shamia L Faison, Nicholas Fry, Toyin Adewole, Oyinkansola Odebo, Stefan Schwabe, Zhao Wang, Vladimir Maletic, Azmi Nasser. Pharmacokinetics of Coadministered Viloxazine Extended-Release (SPN-812) and Methylphenidate in Healthy Adults.
Clinical drug investigation.
2021 Feb; 41(2):149-159. doi:
10.1007/s40261-020-00992-6. [PMID: 33368026] - Raissa Carolina F Cândido, Cristiane A Menezes de Padua, Su Golder, Daniela R Junqueira. Immediate-release methylphenidate for attention deficit hyperactivity disorder (ADHD) in adults.
The Cochrane database of systematic reviews.
2021 01; 1(?):CD013011. doi:
10.1002/14651858.cd013011.pub2. [PMID: 33460048] - Amir Raoofi, Ali Delbari, Davood Mahdian, Mohammad-Shafi Mojadadi, Maedeh Akhlaghi, Ghazaleh Dadashizadeh, Vahid Ebrahimi, Abdollah Amini, Rahim Golmohammadi, Sara Sadat Javadinia, Amin Mousavi Khaneghah. Effects of curcumin nanoparticle on the histological changes and apoptotic factors expression in testis tissue after methylphenidate administration in rats.
Acta histochemica.
2021 Jan; 123(1):151656. doi:
10.1016/j.acthis.2020.151656. [PMID: 33249311] - Robert Lew, Cristian C Constantinescu, Daniel Holden, Richard E Carson, Vincent Carroll, Gerald Galluppi, Kenneth S Koblan, Seth C Hopkins. The rate of dasotraline brain entry is slow following intravenous administration.
Psychopharmacology.
2020 Nov; 237(11):3435-3446. doi:
10.1007/s00213-020-05623-8. [PMID: 32813030] - Martin A Katzman, Greg Mattingly, Larry J Klassen, Marc J Cataldo, Graeme A E Donnelly. Randomized Controlled Crossover Trials of the Pharmacokinetics of PRC-063, a Novel Multilayer Extended-Release Formulation of Methylphenidate, in Healthy Adults.
Journal of clinical psychopharmacology.
2020 Nov; 40(6):579-587. doi:
10.1097/jcp.0000000000001277. [PMID: 33009228] - Anibah Khalid, Umme Aimen Abbasi, Sanila Amber, Sumera, Fatima Javed Mirza, Muhammad Asif, Aneela Javed, Saadia Zahid. Methylphenidate and Rosmarinus officinalis improves cognition and regulates inflammation and synaptic gene expression in AlCl3-induced neurotoxicity mouse model.
Molecular biology reports.
2020 Oct; 47(10):7861-7870. doi:
10.1007/s11033-020-05864-y. [PMID: 33011892] - Amir Raoofi, Ali Delbari, Davood Mahdian, Mohammad-Shafi Mojadadi, Abdollah Amini, Sara Sadat Javadinia, Ghazaleh Dadashizadeh, Behnaz Ahrabi, Vahid Ebrahimi, Amin Mousavi Khaneghah. Toxicology of long-term and high-dose administration of methylphenidate on the kidney tissue - a histopathology and molecular study.
Toxicology mechanisms and methods.
2020 Oct; 30(8):611-619. doi:
10.1080/15376516.2020.1805665. [PMID: 32746681] - Akwete L Adjei, Inder Chaudhary, Scott H Kollins, Americo Padilla. A Pharmacokinetic Study of Methylphenidate Hydrochloride Multilayer Extended-Release Capsules (Aptensio XR®) in Preschool-Aged Children with Attention-Deficit/Hyperactivity Disorder.
Paediatric drugs.
2020 Oct; 22(5):561-570. doi:
10.1007/s40272-020-00409-z. [PMID: 32776159] - Yuli Qian, John S Markowitz. Natural Products as Modulators of CES1 Activity.
Drug metabolism and disposition: the biological fate of chemicals.
2020 10; 48(10):993-1007. doi:
10.1124/dmd.120.000065. [PMID: 32591414] - Kyle B Womack, Rosemary Dubiel, Librada Callender, Cynthia Dunklin, Marie Dahdah, Thomas S Harris, Michael D Devous, Shannon B Juengst, Kathleen Bell, Ramon Diaz-Arrastia, Kan Ding. 123I-Iofluopane Single-Photon Emission Computed Tomography as an Imaging Biomarker of Pre-Synaptic Dopaminergic System after Moderate-to-Severe Traumatic Brain Injury.
Journal of neurotrauma.
2020 10; 37(19):2113-2119. doi:
10.1089/neu.2019.6892. [PMID: 32216525] - Nazanin Aryan, Hamid Reza Banafshe, Vahid Farnia, Jalal Shakeri, Mostafa Alikhani, Habibollah Rahimi, Mojtaba Sehat, Peyman Mamsharifi, Amir Ghaderi, Abdollah Omidi. The therapeutic effects of methylphenidate and matrix-methylphenidate on addiction severity, craving, relapse and mental health in the methamphetamine use disorder.
Substance abuse treatment, prevention, and policy.
2020 09; 15(1):72. doi:
10.1186/s13011-020-00317-y. [PMID: 32977820] - Daria Piacentino, Pietro De Rossi, Georgios D Kotzalidis, Ignazio Maniscalco, Maurizio Pompili, Giancarlo Giupponi, Christoph Hiemke, Andreas Conca. Methylphenidate challenge test in adults with attention deficit/hyperactivity disorder (ADHD): Clinical effects and their predictors.
Human psychopharmacology.
2020 09; 35(5):e2740. doi:
10.1002/hup.2740. [PMID: 32785944] - Cian-Ling Jhang, Hom-Yi Lee, Jin-Chung Chen, Wenlin Liao. Dopaminergic loss of cyclin-dependent kinase-like 5 recapitulates methylphenidate-remediable hyperlocomotion in mouse model of CDKL5 deficiency disorder.
Human molecular genetics.
2020 08; 29(14):2408-2419. doi:
10.1093/hmg/ddaa122. [PMID: 32588892] - Vitor S Tardelli, Adam Bisaga, Felipe B Arcadepani, Gilberto Gerra, Frances R Levin, Thiago M Fidalgo. Prescription psychostimulants for the treatment of stimulant use disorder: a systematic review and meta-analysis.
Psychopharmacology.
2020 Aug; 237(8):2233-2255. doi:
10.1007/s00213-020-05563-3. [PMID: 32601988] - Ottavia Dipasquale, Daniel Martins, Arjun Sethi, Mattia Veronese, Swen Hesse, Michael Rullmann, Osama Sabri, Federico Turkheimer, Neil A Harrison, Mitul A Mehta, Mara Cercignani. Unravelling the effects of methylphenidate on the dopaminergic and noradrenergic functional circuits.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2020 08; 45(9):1482-1489. doi:
10.1038/s41386-020-0724-x. [PMID: 32473593] - Vincent Chin-Hung Chen, Yao-Hsu Yang, Ting Yu Kuo, Mong-Liang Lu, Wei-Ting Tseng, Tsai-Yu Hou, Jia-Ying Yeh, Charles Tzu-Chi Lee, Yi-Lung Chen, Min-Jing Lee, Michael E Dewey, Michael Gossop. Methylphenidate and the risk of burn injury among children with attention-deficit/hyperactivity disorder.
Epidemiology and psychiatric sciences.
2020 Jul; 29(?):e146. doi:
10.1017/s2045796020000608. [PMID: 32686635] - Gideon Charach, Eli Karniel, Itamar Grosskopf, Alexander Rabinovich, Lior Charach. Methylphenidate has mild hyperglycemic and hypokalemia effects and increases leukocyte and neutrophil counts.
Medicine.
2020 Jul; 99(27):e20931. doi:
10.1097/md.0000000000020931. [PMID: 32629693] - Shiho Suzuki, Ryo Kimura, Shingo Maegawa, Masatoshi Nakata, Masatoshi Hagiwara. Different effects of methylphenidate and atomoxetine on the behavior and brain transcriptome of zebrafish.
Molecular brain.
2020 05; 13(1):70. doi:
10.1186/s13041-020-00614-4. [PMID: 32375837] - Cristiana Carbone, Anna Brancato, Annalisa Adinolfi, Sara Lucia Maria Lo Russo, Enrico Alleva, Carla Cannizzaro, Walter Adriani. Motor Transitions' Peculiarity of Heterozygous DAT Rats When Offspring of an Unconventional KOxWT Mating.
Neuroscience.
2020 05; 433(?):108-120. doi:
10.1016/j.neuroscience.2020.03.005. [PMID: 32171819] - Meenu Dutt, Ravinder Naik Dharavath, Tanzeer Kaur, Navpreet Kaur, Kanwaljit Chopra, Shweta Sharma. Co-abuse of alprazolam augments the hepato-renal toxic effects of methylphenidate.
Indian journal of pharmacology.
2020 May; 52(3):216-221. doi:
10.4103/ijp.ijp_758_19. [PMID: 32874006] - Gaia Faustini, Francesca Longhena, Agostino Bruno, Federica Bono, Jessica Grigoletto, Luca La Via, Alessandro Barbon, Andrea Casiraghi, Valentina Straniero, Ermanno Valoti, Gabriele Costantino, Fabio Benfenati, Cristina Missale, Marina Pizzi, Maria Grazia Spillantini, Arianna Bellucci. Alpha-synuclein/synapsin III pathological interplay boosts the motor response to methylphenidate.
Neurobiology of disease.
2020 05; 138(?):104789. doi:
10.1016/j.nbd.2020.104789. [PMID: 32032728] - Luisa Fernández-López, Antonio Molina-Carballo, Isabel Cubero-Millán, Ana Checa-Ros, Irene Machado-Casas, Enrique Blanca-Jover, Antonio Jerez-Calero, Yolanda Madrid-Fernández, José Uberos, Antonio Muñoz-Hoyos. Indole Tryptophan Metabolism and Cytokine S100B in Children with Attention-Deficit/Hyperactivity Disorder: Daily Fluctuations, Responses to Methylphenidate, and Interrelationship with Depressive Symptomatology.
Journal of child and adolescent psychopharmacology.
2020 04; 30(3):177-188. doi:
10.1089/cap.2019.0072. [PMID: 32048862] - Sascha K Manier, Sophia Niedermeier, Jan Schäper, Markus R Meyer. Use of UPLC-HRMS/MS for In Vitro and In Vivo Metabolite Identification of Three Methylphenidate-derived New Psychoactive Substances.
Journal of analytical toxicology.
2020 Mar; 44(2):156-162. doi:
10.1093/jat/bkz052. [PMID: 31355413] - Tianyi Chen, Haixia Yuan, Yu-Bo Sun, Yu-Chen Song, Manqi Lu, Xinqiang Ni, Xinmin Han. Metabolomics study of the prefrontal cortex in a rat model of attention deficit hyperactivity disorder reveals the association between cholesterol metabolism disorder and hyperactive behavior.
Biochemical and biophysical research communications.
2020 03; 523(2):315-321. doi:
10.1016/j.bbrc.2019.12.016. [PMID: 31864712] - Mai Hoang Philipsen, Nhu T N Phan, John Stephen Fletcher, Andrew G Ewing. Interplay between Cocaine, Drug Removal, and Methylphenidate Reversal on Phospholipid Alterations in Drosophila Brain Determined by Imaging Mass Spectrometry.
ACS chemical neuroscience.
2020 03; 11(5):806-813. doi:
10.1021/acschemneuro.0c00014. [PMID: 32045198] - Hajra Mazhar, Brian C Foster, Candace Necyk, Paula M Gardiner, Cory S Harris, Philippe Robaey. Natural Health Product-Drug Interaction Causality Assessment in Pediatric Adverse Event Reports Associated with Attention-Deficit/Hyperactivity Disorder Medication.
Journal of child and adolescent psychopharmacology.
2020 02; 30(1):38-47. doi:
10.1089/cap.2019.0102. [PMID: 31670573] - Michel Arvidsson, Marja-Liisa Dahl, Olof Beck, Gerd Ackehed, Karin Nordin, Staffan Rosenborg. Pharmacokinetics of methylphenidate and ritalinic acid in plasma correlations with exhaled breath and oral fluid in healthy volunteers.
European journal of clinical pharmacology.
2020 Feb; 76(2):229-237. doi:
10.1007/s00228-019-02787-x. [PMID: 31786618] - Eva Martinez, Benjamin Pasquereau, Guillaume Drui, Yosuke Saga, Élise Météreau, Léon Tremblay. Ventral striatum supports Methylphenidate therapeutic effects on impulsive choices expressed in temporal discounting task.
Scientific reports.
2020 01; 10(1):716. doi:
10.1038/s41598-020-57595-6. [PMID: 31959838] - Jae Hyun Yoo, Vinod Sharma, Jae-Won Kim, Dana L McMakin, Soon-Beom Hong, Andrew Zalesky, Bung-Nyun Kim, Neal D Ryan. Prediction of sleep side effects following methylphenidate treatment in ADHD youth.
NeuroImage. Clinical.
2020; 26(?):102030. doi:
10.1016/j.nicl.2019.102030. [PMID: 31711956] - Sabrina Lehmann, Tobias Kieliba, Mario Thevis, Markus A Rothschild, Katja Mercer-Chalmers-Bender. Fatalities associated with NPS stimulants in the Greater Cologne area.
International journal of legal medicine.
2020 Jan; 134(1):229-241. doi:
10.1007/s00414-019-02193-z. [PMID: 31735981] - Stephanie Maxine Ross. Saffron (Crocus sativus L.): A Phytomedicine as Effective as Methylphenidate in Treating ADHD in Children.
Holistic nursing practice.
2020 Jan; 34(1):65-67. doi:
10.1097/hnp.0000000000000365. [PMID: 31725101] - Vanessa Coelho-Santos, Filipa L Cardoso, Ana Magalhães, Margarida Ferreira-Teixeira, Ricardo A Leitão, Célia Gomes, Manuel Rito, Marcos Barbosa, Carlos A Fontes-Ribeiro, Ana Paula Silva. Effect of chronic methylphenidate treatment on hippocampal neurovascular unit and memory performance in late adolescent rats.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2019 12; 29(2):195-210. doi:
10.1016/j.euroneuro.2018.12.007. [PMID: 30554860] - Brian Chan, Michele Freeman, Karli Kondo, Chelsea Ayers, Jessica Montgomery, Robin Paynter, Devan Kansagara. Pharmacotherapy for methamphetamine/amphetamine use disorder-a systematic review and meta-analysis.
Addiction (Abingdon, England).
2019 12; 114(12):2122-2136. doi:
10.1111/add.14755. [PMID: 31328345] - Jing Gan, Peter Galer, Dan Ma, Chao Chen, Tao Xiong. The Effect of Vitamin D Supplementation on Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Journal of child and adolescent psychopharmacology.
2019 11; 29(9):670-687. doi:
10.1089/cap.2019.0059. [PMID: 31368773] - Cem Gokcen, Ayse Binnur Erbagci, Tuba Mutluer, Mustafa Orkmez, Christoph U Correll. Mullerian inhibiting substance, sex hormone binding globulin and sex hormone levels in stimulant-naïve, first-diagnosed prepubertal boys with attention-deficit/hyperactivity disorder: comparison with matched healthy controls as well as before and after oros-methylpenidate treatment.
International journal of psychiatry in clinical practice.
2019 Nov; 23(4):251-257. doi:
10.1080/13651501.2019.1602657. [PMID: 31339400] - Chloe J Jordan, Jianjing Cao, Amy Hauck Newman, Zheng-Xiong Xi. Progress in agonist therapy for substance use disorders: Lessons learned from methadone and buprenorphine.
Neuropharmacology.
2019 11; 158(?):107609. doi:
10.1016/j.neuropharm.2019.04.015. [PMID: 31009632] - Haixia Yuan, Xinqiang Ni, Min Zheng, Xinmin Han, Yuchen Song, Minfeng Yu. Effect of catalpol on behavior and neurodevelopment in an ADHD rat model.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Oct; 118(?):109033. doi:
10.1016/j.biopha.2019.109033. [PMID: 31545235] - Barkha J Yadav-Samudrala, Jose M Eltit, Richard A Glennon. Synthetic Cathinone Analogues Structurally Related to the Central Stimulant Methylphenidate as Dopamine Reuptake Inhibitors.
ACS chemical neuroscience.
2019 09; 10(9):4043-4050. doi:
10.1021/acschemneuro.9b00284. [PMID: 31369229] - Elisa N Shoff, Joseph H Kahl, George W Hime, Marta Coburn, Diane M Boland. 4-Fluoromethylphenidate: Fatal Intoxication Involving a Previously Unreported Novel Psychoactive Substance in the USA.
Journal of analytical toxicology.
2019 Sep; 43(8):666-672. doi:
10.1093/jat/bkz061. [PMID: 31424072] - Ana Checa-Ros, Ana Haro-García, Isabel Seiquer, Antonio Molina-Carballo, José Uberos-Fernández, Antonio Muñoz-Hoyos. Early monitoring of fatty acid profile in children with attention deficit and/or hyperactivity disorder under treatment with omega-3 polyunsaturated fatty acids.
Minerva pediatrica.
2019 Aug; 71(4):313-325. doi:
10.23736/s0026-4946.18.04975-7. [PMID: 30419741] - Isabela Gertrudes Batalhão, Daína Lima, Ana Paula Montedor Russi, Camila Nomura Pereira Boscolo, Danilo Grunig Humberto Silva, Thiago Scremin Boscolo Pereira, Afonso Celso Dias Bainy, Eduardo Alves de Almeida. Effects of methylphenidate on the aggressive behavior, serotonin and dopamine levels, and dopamine-related gene transcription in brain of male Nile tilapia (Oreochromis niloticus).
Fish physiology and biochemistry.
2019 Aug; 45(4):1377-1391. doi:
10.1007/s10695-019-00645-2. [PMID: 31054043] - Peter O Jenkins, Sara De Simoni, Niall J Bourke, Jessica Fleminger, Gregory Scott, David J Towey, William Svensson, Sameer Khan, Maneesh C Patel, Richard Greenwood, Daniel Friedland, Adam Hampshire, James H Cole, David J Sharp. Stratifying drug treatment of cognitive impairments after traumatic brain injury using neuroimaging.
Brain : a journal of neurology.
2019 08; 142(8):2367-2379. doi:
10.1093/brain/awz149. [PMID: 31199462] - Tyler Stevens, Katrin Sangkuhl, Jacob T Brown, Russ B Altman, Teri E Klein. PharmGKB summary: methylphenidate pathway, pharmacokinetics/pharmacodynamics.
Pharmacogenetics and genomics.
2019 08; 29(6):136-154. doi:
10.1097/fpc.0000000000000376. [PMID: 30950912] - Monireh Sadat Motaharifard, Mohammad Effatpanah, Mehrdad Karimi, Shahin Akhondzadeh, Habibollah Rahimi, Seyed Ali Yasrebi, Fatemeh Nejatbakhsh. Effect of sweet almond syrup versus methylphenidate in children with ADHD: A randomized triple-blind clinical trial.
Complementary therapies in clinical practice.
2019 Aug; 36(?):170-175. doi:
10.1016/j.ctcp.2019.07.008. [PMID: 31383435] - Lixia Yan, Siyuan Wang, Yang Yuan, Junhua Zhang. Effects of neurofeedback versus methylphenidate for the treatment of ADHD: systematic review and meta-analysis of head-to-head trials.
Evidence-based mental health.
2019 08; 22(3):111-117. doi:
10.1136/ebmental-2019-300088. [PMID: 31221690] - Kennerly S Patrick, Wendy Rodriguez. Potential for Underestimation of d-Methylphenidate Bioavailability Using Chiral Derivatization/Gas Chromatography.
Drug metabolism and disposition: the biological fate of chemicals.
2019 07; 47(7):764-767. doi:
10.1124/dmd.119.087189. [PMID: 31028056] - Anne Zwartsen, Carlijn H C Litjens, Laura Hondebrink, Jeroen J M W van den Heuvel, Rick Greupink, Frans G M Russel, Dylan W de Lange, Juliette Legler, Jan B Koenderink, Remco H S Westerink. Differential effects of psychoactive substances on human wildtype and polymorphic T356M dopamine transporters (DAT).
Toxicology.
2019 06; 422(?):69-75. doi:
10.1016/j.tox.2019.04.012. [PMID: 31009648] - Pietro Papa, Antonella Valli, Marcello Di Tuccio, Giampietro Frison, Flavio Zancanaro, Eleonora Buscaglia, Carlo Alessandro Locatelli. Analytically Confirmed Intoxication by 4-Fluoromethylphenidate, an Analog of Methylphenidate.
Journal of analytical toxicology.
2019 Jun; 43(5):e1-e7. doi:
10.1093/jat/bkz001. [PMID: 30843073] - Patrícia Maidana Miguel, Bruna Ferrary Deniz, Heloísa Deola Confortim, Loise Peres Bronauth, Bruna Chaves de Oliveira, Márcio Bonesso Alves, Patrícia Pelufo Silveira, Lenir Orlandi Pereira. Methylphenidate administration reverts attentional inflexibility in adolescent rats submitted to a model of neonatal hypoxia-ischemia: Predictive validity for ADHD study.
Experimental neurology.
2019 05; 315(?):88-99. doi:
10.1016/j.expneurol.2019.02.004. [PMID: 30771298] - Jordan M Buck, Kelsey N Sanders, Charles R Wageman, Valerie S Knopik, Jerry A Stitzel, Heidi C O'Neill. Developmental nicotine exposure precipitates multigenerational maternal transmission of nicotine preference and ADHD-like behavioral, rhythmometric, neuropharmacological, and epigenetic anomalies in adolescent mice.
Neuropharmacology.
2019 05; 149(?):66-82. doi:
10.1016/j.neuropharm.2019.02.006. [PMID: 30742847] - Ryosuke Shimizu, Naotaka Horiguchi, Koji Yano, Masashi Sakuramoto, Naoki Kanegawa, Shunji Shinohara, Shuichi Ohnishi. Pharmacokinetic-Pharmacodynamic Modeling of Brain Dopamine Levels Based on Dopamine Transporter Occupancy after Administration of Methylphenidate in Rats.
The Journal of pharmacology and experimental therapeutics.
2019 04; 369(1):78-87. doi:
10.1124/jpet.118.252262. [PMID: 30674560] - Adele Stewart, Gwynne L Davis, Paul J Gresch, Rania M Katamish, Rodeania Peart, Maximilian J Rabil, Raajaram Gowrishankar, F Ivy Carroll, Maureen K Hahn, Randy D Blakely. Serotonin transporter inhibition and 5-HT2C receptor activation drive loss of cocaine-induced locomotor activation in DAT Val559 mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2019 04; 44(5):994-1006. doi:
10.1038/s41386-018-0301-8. [PMID: 30578419] - Courtney A Marshall, Zachary D Brodnik, Ole V Mortensen, Maarten E A Reith, Jed S Shumsky, Barry D Waterhouse, Rodrigo A España, Sandhya Kortagere. Selective activation of Dopamine D3 receptors and norepinephrine transporter blockade enhances sustained attention.
Neuropharmacology.
2019 04; 148(?):178-188. doi:
10.1016/j.neuropharm.2019.01.003. [PMID: 30633928] - John P Dougherty, Danielle A Springer, Mary J Cullen, Marvin C Gershengorn. Evaluation of the effects of chemotherapy-induced fatigue and pharmacological interventions in multiple mouse behavioral assays.
Behavioural brain research.
2019 03; 360(?):255-261. doi:
10.1016/j.bbr.2018.12.011. [PMID: 30529403] - Emmanuel Quansah, Tyra S C Zetterström. Chronic methylphenidate preferentially alters catecholamine protein targets in the parietal cortex and ventral striatum.
Neurochemistry international.
2019 03; 124(?):193-199. doi:
10.1016/j.neuint.2019.01.016. [PMID: 30660754] - Nausheen Alam, Nousheen Wasi, Sadaf Naeem, Sadia Suri Kashif, Tuba Siddiqui, Lubna Bashir, Shazia Naz, Rahila Ikram. Methylphenidate increases the urinary excretion of vanillylmandelic acid in rats that is attenuated by buspirone co-administration.
Pakistan journal of pharmaceutical sciences.
2019 Mar; 32(2 (Supplementary)):895-898. doi:
. [PMID: 31103989] - Thomas Iliou, Pauline Casta, Judy Lequeux, Liselotte Pochard, Elisabeth Frauger, Michel Spadari, Joëlle Micallef. Venlafaxine Abuse in a Patient With a History of Methylphenidate Abuse: A Case Report.
Journal of clinical psychopharmacology.
2019 Mar; 39(2):172-174. doi:
10.1097/jcp.0000000000001011. [PMID: 30811375] - Rasmus M Birn, Alexander K Converse, Abigail Z Rajala, Andrew L Alexander, Walter F Block, Alan B McMillan, Bradley T Christian, Caitlynn N Filla, Dhanabalan Murali, Samuel A Hurley, Rick L Jenison, Luis C Populin. Changes in Endogenous Dopamine Induced by Methylphenidate Predict Functional Connectivity in Nonhuman Primates.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2019 02; 39(8):1436-1444. doi:
10.1523/jneurosci.2513-18.2018. [PMID: 30530859] - Shu-Cheng Chen, Branda Yee-Man Yu, Lorna Kwai-Ping Suen, Juan Yu, Fiona Yan-Yee Ho, Jun-Jun Yang, Wing-Fai Yeung. Massage therapy for the treatment of attention deficit/hyperactivity disorder (ADHD) in children and adolescents: A systematic review and meta-analysis.
Complementary therapies in medicine.
2019 Feb; 42(?):389-399. doi:
10.1016/j.ctim.2018.12.011. [PMID: 30670272] - James D Wilkinson, Ralph Callicott, William F Salminen, Satinder K Sandhu, James Greenhaw, Angel Paredes, Kelly Davis, Yvonne Jones, Merle G Paule, William Slikker, Paolo G Rusconi, Jason Czachor, Amy Bodien, Joslyn A Westphal, Danielle D Dauphin, Steven E Lipshultz. A randomized controlled laboratory study on the long-term effects of methylphenidate on cardiovascular function and structure in rhesus monkeys.
Pediatric research.
2019 02; 85(3):398-404. doi:
10.1038/s41390-018-0256-9. [PMID: 30555154] - Danielly Chierrito, Camila B Villas-Boas, Fernanda S Tonin, Fernando Fernandez-Llimos, Andréia C C Sanches, João C P de Mello. Using Cell Cultures for the Investigation of Treatments for Attention Deficit Hyperactivity Disorder: A Systematic Review.
Current neuropharmacology.
2019; 17(10):916-925. doi:
10.2174/1570159x17666190409143155. [PMID: 31079591] - Nico Adelhöfer, Krutika Gohil, Susanne Passow, Benjamin Teufert, Veit Roessner, Shu-Chen Li, Christian Beste. The system-neurophysiological basis for how methylphenidate modulates perceptual-attentional conflicts during auditory processing.
Human brain mapping.
2018 12; 39(12):5050-5061. doi:
10.1002/hbm.24344. [PMID: 30133058] - Wakaho Hayashi, Akira Iwanami. [Biological Mechanisms of ADHD].
Brain and nerve = Shinkei kenkyu no shinpo.
2018 Nov; 70(11):1265-1277. doi:
10.11477/mf.1416201172. [PMID: 30416120] - Heather K Knych, Dan S McKemie, Kelsey Seminoff, Petra Hartmann, Lynn Hovda, Dionne Benson. L- and D-threo ethylphenidate concentrations, pharmacokinetics, and pharmacodynamics in horses.
Drug testing and analysis.
2018 Oct; 10(10):1508-1517. doi:
10.1002/dta.2408. [PMID: 29786965] - Rami Bou Khalil, Viviane Smayra, Youakim Saliba, Joelle Hajal, Jules-Joël Bakhos, Lama Souaiby, Sami Richa, Jean Tamraz, Nassim Farès. Mifepristone reduces hypothalamo-pituitary-adrenal axis activation and restores weight loss in rats subjected to dietary restriction and methylphenidate administration.
Neuroscience research.
2018 Oct; 135(?):46-53. doi:
10.1016/j.neures.2017.12.008. [PMID: 29288690] - Soichiro Ide, Yuiko Ikekubo, Jennifer Hua, Yukio Takamatsu, George R Uhl, Ichiro Sora, Kazutaka Ikeda. Reward-enhancing effect of methylphenidate is abolished in dopamine transporter knockout mice: A model of attention-deficit/hyperactivity disorder.
Neuropsychopharmacology reports.
2018 09; 38(3):149-153. doi:
10.1002/npr2.12020. [PMID: 30175528] - Hai-Xia Yuan, Xin-Qiang Ni, Zheng-Zhi Wu, Xin-Min Han, Dan-Gui Xu, Yu-Chen Song, Tian-Yi Chen. [Regulatory effect of Shudihuang on expressions of BDNF/TrkB and NRG-3 in prefrontal cortex and striatum of ADHD model rats].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2018 Sep; 43(17):3539-3544. doi:
10.19540/j.cnki.cjcmm.20180522.004. [PMID: 30347924] - Lixia Yan, Junhua Zhang, Yang Yuan, Samuele Cortese. Effects of neurofeedback versus methylphenidate for the treatment of attention-deficit/hyperactivity disorder protocol for a systematic review and meta-analysis of head-to-head trials.
Medicine.
2018 Sep; 97(39):e12623. doi:
10.1097/md.0000000000012623. [PMID: 30278582] - N M Myer, J R Boland, S V Faraone. Pharmacogenetics predictors of methylphenidate efficacy in childhood ADHD.
Molecular psychiatry.
2018 09; 23(9):1929-1936. doi:
10.1038/mp.2017.234. [PMID: 29230023] - Aynur Pekcanlar Akay, Gamze Çapa Kaya, Samet Kose, Çiğdem Eresen Yazıcıoğlu, Handan Özek Erkuran, Sevay Alşen Güney, Kaya Oğuz, Duygu Keskin, Burak Baykara, Neslihan İnal Emiroğlu, Mine Şencan Eren, Sefa Kızıldağ, Türkan Ertay, Dua Özsoylu, Süha Miral, Hatice Durak, Ali Saffet Gönül, Luis Augusto Rohde. Genetic imaging study with [Tc-99m] TRODAT-1 SPECT in adolescents with ADHD using OROS-methylphenidate.
Progress in neuro-psychopharmacology & biological psychiatry.
2018 08; 86(?):294-300. doi:
10.1016/j.pnpbp.2018.04.008. [PMID: 29684537] - Chin-Hsiung Wang, Hung Su, Jo-Han Chou, Min-Zong Huang, Hsing-Jung Lin, Jentaie Shiea. Solid phase microextraction combined with thermal-desorption electrospray ionization mass spectrometry for high-throughput pharmacokinetics assays.
Analytica chimica acta.
2018 Aug; 1021(?):60-68. doi:
10.1016/j.aca.2018.03.002. [PMID: 29681285] - Carmen T Mulet, Luis E Arroyo-Mora, Lorena A Leon, Elizabeth Gnagy, Anthony P DeCaprio. Rapid quantitative analysis of methylphenidate and ritalinic acid in oral fluid by liquid chromatography triple quadrupole mass spectrometry (LC-QqQ-MS).
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Aug; 1092(?):313-319. doi:
10.1016/j.jchromb.2018.06.025. [PMID: 29935479] - Joshua Preiskorn, Sophie Studer, Reinhold Rauh, Richard Lukačin, Christoph Geffert, Christian Fleischhaker, Hans-Willi Clement, Eberhard Schulz, Monica Biscaldi. Interindividual and Intraindividual Variation of Methylphenidate Concentrations in Serum and Saliva of Patients With Attention-Deficit/Hyperactivity Disorder.
Therapeutic drug monitoring.
2018 08; 40(4):435-442. doi:
10.1097/ftd.0000000000000520. [PMID: 29750737] - Rima Kaddurah-Daouk, Thomas Hankemeier, Elizabeth H Scholl, Rebecca Baillie, Amy Harms, Claus Stage, Kim P Dalhoff, Gesche Jűrgens, Olivier Taboureau, Grace S Nzabonimpa, Alison A Motsinger-Reif, Ragnar Thomsen, Kristian Linnet, Henrik B Rasmussen. Pharmacometabolomics Informs About Pharmacokinetic Profile of Methylphenidate.
CPT: pharmacometrics & systems pharmacology.
2018 08; 7(8):525-533. doi:
10.1002/psp4.12309. [PMID: 30169917] - Aza Kobakhidze, Vladimir Elisashvili, Philippe F-X Corvini, Monika Čvančarová. Biotransformation of ritalinic acid by laccase in the presence of mediator TEMPO.
New biotechnology.
2018 Jul; 43(?):44-52. doi:
10.1016/j.nbt.2017.08.008. [PMID: 28855123]
