3-methyladenine (BioDeep_00000400011)

Main id: BioDeep_00000001843

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


3-methyladenine

化学式: C6H7N5 (149.07014220000002)
中文名称: 3-甲基腺嘌呤
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1C=NC(=C2C1=NC=N2)N
InChI: InChI=1/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3H,7H2,1H3

描述信息

A methyladenine that is adenine substituted with a methyl group at position N-3.

同义名列表

1 个代谢物同义名

3-methyladenine



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(1)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kun Wang, Jiatong Tang, Shengxian Fan, Haochen Su, Ranran Yu, Yixuan Zhang, Hao Wu, Ying Lv, Shu Zhang, Xiaoping Zou. ABBV-744 induces autophagy in gastric cancer cells by regulating PI3K/AKT/mTOR/p70S6k and MAPK signaling pathways. Neoplasia (New York, N.Y.). 2023 11; 45(?):100936. doi: 10.1016/j.neo.2023.100936. [PMID: 37769529]
  • Lihua Cui, Caixia Li, Guixian Zhang, Lanqiu Zhang, Guowang Yao, Yuzhen Zhuo, Naiqiang Cui, Shukun Zhang. S1P/S1PR2 promote pancreatic stellate cell activation and pancreatic fibrosis in chronic pancreatitis by regulating autophagy and the NLRP3 inflammasome. Chemico-biological interactions. 2023 May; 380(?):110541. doi: 10.1016/j.cbi.2023.110541. [PMID: 37169277]
  • Yuting Wu, Cheng Huang, Tianlu Shi, Jun Li. Deficiency of NLR family member NLRC5 alleviates alcohol induced hepatic injury and steatosis by enhancing autophagy of hepatocytes. Toxicology and applied pharmacology. 2023 Feb; 461(?):116406. doi: 10.1016/j.taap.2023.116406. [PMID: 36708882]
  • Ting Li, Jie Zhao, Shuying Miao, Yiyang Chen, Yunfei Xu, Ying Liu. Protective effect of H2S on LPS‑induced AKI by promoting autophagy. Molecular medicine reports. 2022 03; 25(3):. doi: 10.3892/mmr.2022.12612. [PMID: 35059738]
  • Yujie Zhong, Dianjun Sun, Yanpeng Yao, Qi Liu, Tianmin Guo, Xin Wang, Xiaoli Peng. Autophagy and mitochondrial dynamics contribute to the protective effect of diosgenin against 3-MCPD induced kidney injury. Chemico-biological interactions. 2022 Mar; 355(?):109850. doi: 10.1016/j.cbi.2022.109850. [PMID: 35149085]
  • Ibrahim Morgan, Ludger A Wessjohann, Goran N Kaluđerović. In Vitro Anticancer Screening and Preliminary Mechanistic Study of A-Ring Substituted Anthraquinone Derivatives. Cells. 2022 01; 11(1):. doi: 10.3390/cells11010168. [PMID: 35011730]
  • Nan Yang, Yunxiao Shang. Ferrostatin-1 and 3-Methyladenine Ameliorate Ferroptosis in OVA-Induced Asthma Model and in IL-13-Challenged BEAS-2B Cells. Oxidative medicine and cellular longevity. 2022; 2022(?):9657933. doi: 10.1155/2022/9657933. [PMID: 35154576]
  • Jieyu Yue, Yingjie Wang, Jinlan Jiao, Huazhong Wang. Comparative transcriptomic and metabolic profiling provides insight into the mechanism by which the autophagy inhibitor 3-MA enhances salt stress sensitivity in wheat seedlings. BMC plant biology. 2021 Dec; 21(1):577. doi: 10.1186/s12870-021-03351-5. [PMID: 34872497]
  • Yongteng Zhao, Jing Cui, Qingqing Li, Tengsheng Qiao, Du-Bo Zhong, Peng Zhao, Xuya Yu. A joint strategy comprising melatonin and 3-methyladenine to concurrently stimulate biomass and astaxanthin hyperaccumulation by Haematococcus pluvialis. Bioresource technology. 2021 Dec; 341(?):125784. doi: 10.1016/j.biortech.2021.125784. [PMID: 34419876]
  • Junping Guo, Wei Chen, Beibei Bao, Dayong Zhang, Jianping Pan, Mao Zhang. Protective effect of berberine against LPS-induced endothelial cell injury via the JNK signaling pathway and autophagic mechanisms. Bioengineered. 2021 12; 12(1):1324-1337. doi: 10.1080/21655979.2021.1915671. [PMID: 33896366]
  • Jinghui Zhai, Huan Gao, Shuo Wang, Sixi Zhang, Xiaoyu Qu, Yueming Zhang, Lina Tao, Jingmeng Sun, Yanqing Song, Li Fu. Ginsenoside Rg3 attenuates cisplatin-induced kidney injury through inhibition of apoptosis and autophagy-inhibited NLRP3. Journal of biochemical and molecular toxicology. 2021 Nov; 35(11):e22896. doi: 10.1002/jbt.22896. [PMID: 34423507]
  • Myriam Mireault, Yong Xiao, Benoît Barbeau, Catherine Jumarie. Cadmium affects autophagy in the human intestinal cells Caco-2 through ROS-mediated ERK activation. Cell biology and toxicology. 2021 Sep; ?(?):. doi: 10.1007/s10565-021-09655-4. [PMID: 34580807]
  • Jiarui Zhao, Bo Hu, Han Xiao, Qiong Yang, Qi Cao, Xia Li, Qian Zhang, Aiguo Ji, Shuliang Song. Fucoidan reduces lipid accumulation by promoting foam cell autophagy via TFEB. Carbohydrate polymers. 2021 Sep; 268(?):118247. doi: 10.1016/j.carbpol.2021.118247. [PMID: 34127226]
  • Liang Pei, Linxi He. Hepatoprotective effect of anemoside B4 against sepsis-induced acute liver injury through modulating the mTOR/p70S6K-mediated autophagy. Chemico-biological interactions. 2021 Aug; 345(?):109534. doi: 10.1016/j.cbi.2021.109534. [PMID: 34051206]
  • Di Liu, Wan-Pin Sun, Jing-Wei Chen, Yan Jiang, Rong Xue, Lin-Hui Wang, Koji Murao, Guo-Xing Zhang. Autophagy contributes to angiotensin II induced dysfunction of HUVECs. Clinical and experimental hypertension (New York, N.Y. : 1993). 2021 Jul; 43(5):462-473. doi: 10.1080/10641963.2021.1901110. [PMID: 33775188]
  • Alberto Ruiz Priego, Emilio González Parra, Sebastián Mas, José Luis Morgado-Pascual, Marta Ruiz-Ortega, Sandra Rayego-Mateos. Bisphenol A Modulates Autophagy and Exacerbates Chronic Kidney Damage in Mice. International journal of molecular sciences. 2021 Jul; 22(13):. doi: 10.3390/ijms22137189. [PMID: 34281243]
  • Rong Tang, Liu Jia, Yunlong Li, Junbo Zheng, Pingping Qi. Narciclasine attenuates sepsis-induced myocardial injury by modulating autophagy. Aging. 2021 05; 13(11):15151-15163. doi: 10.18632/aging.203078. [PMID: 34035183]
  • Hsin-Ling Yang, Hui-Wen Liu, Sirjana Shrestha, Varadharajan Thiyagarajan, Hui-Chi Huang, You-Cheng Hseu. Antrodia salmonea induces apoptosis and enhances cytoprotective autophagy in colon cancer cells. Aging. 2021 05; 13(12):15964-15989. doi: 10.18632/aging.203019. [PMID: 34031264]
  • Jin Wang, Dan Li, Zhinan Zhang, Yan Zhang, Zhandong Lei, Wenwen Jin, Jimin Cao, Xiangying Jiao. Autoantibody against angiotensin II type I receptor induces pancreatic β-cell apoptosis via enhancing autophagy. Acta biochimica et biophysica Sinica. 2021 May; 53(6):784-795. doi: 10.1093/abbs/gmab049. [PMID: 33928341]
  • Ying Liu, Jiawei Xu, Tian Liu, Jinxiang Wu, Jiping Zhao, Junfei Wang, Minfang Zou, Lili Cao, Xiaofei Liu, Yun Pan, Siyuan Huang, Liang Dong. FSTL1 aggravates cigarette smoke-induced airway inflammation and airway remodeling by regulating autophagy. BMC pulmonary medicine. 2021 Jan; 21(1):45. doi: 10.1186/s12890-021-01409-6. [PMID: 33509151]
  • Xiang Liu, Chunyan Yang, Ying Deng, Ping Liu, Hongqiu Yang, Xiaoshuang Du, Yu Du. Polygoni Multiflori Radix Preparat Delays Skin Aging by Inducing Mitophagy. BioMed research international. 2021; 2021(?):5847153. doi: 10.1155/2021/5847153. [PMID: 33511202]
  • Zixuan Liu, Xuying Lv, Erqun Song, Yang Song. Fostered Nrf2 expression antagonizes iron overload and glutathione depletion to promote resistance of neuron-like cells to ferroptosis. Toxicology and applied pharmacology. 2020 11; 407(?):115241. doi: 10.1016/j.taap.2020.115241. [PMID: 32937103]
  • Yaomin Wang, Chen Xia, Lianfu Chen, Yi Charlie Chen, Youying Tu. Saponins Extracted from Tea (Camellia Sinensis) Flowers Induces Autophagy in Ovarian Cancer Cells. Molecules (Basel, Switzerland). 2020 Nov; 25(22):. doi: 10.3390/molecules25225254. [PMID: 33187244]
  • Mikyoung You, Young-Hyun Lee, Hwa-Jin Kim, Ji Hyun Kook, Hyeon-A Kim. St. John's Wort Suppresses Growth in Triple-Negative Breast Cancer Cell Line MDA-MB-231 by Inducing Prodeath Autophagy and Apoptosis. Nutrients. 2020 Oct; 12(10):. doi: 10.3390/nu12103175. [PMID: 33080824]
  • Tongjian Zhao, Jie Ma, Lulu Li, Wenjing Teng, Yafei Tian, Yongjun Ma, Wei Wang, Weiqun Yan, Ping Jiao. MKP-5 Relieves Lipotoxicity-Induced Islet β-Cell Dysfunction and Apoptosis via Regulation of Autophagy. International journal of molecular sciences. 2020 Sep; 21(19):. doi: 10.3390/ijms21197161. [PMID: 32998359]
  • Juan-Ting Liu, Jaramar Balmori-Cedeno, Ehab Misk, John S Lumsden. Pharmacological and nutritional modulation of autophagy in a rainbow trout (Oncorhynchus mykiss) gill cell line, RTgill-W1. In vitro cellular & developmental biology. Animal. 2020 Sep; 56(8):659-669. doi: 10.1007/s11626-020-00490-1. [PMID: 32901427]
  • Xiaofang Tan, Huifeng Guan, Yang Yang, Shenying Luo, Lina Hou, Hongzhuan Chen, Juan Li. Cu(II) disrupts autophagy-mediated lysosomal degradation of oligomeric Aβ in microglia via mTOR-TFEB pathway. Toxicology and applied pharmacology. 2020 08; 401(?):115090. doi: 10.1016/j.taap.2020.115090. [PMID: 32512069]
  • Chun-Yu Liu, Min Wang, Hong-Min Yu, Fang-Xuan Han, Qiong-Shi Wu, Xing-Jun Cai, Hiroshi Kurihara, Yong-Xing Chen, Yi-Fang Li, Rong-Rong He. Ferroptosis is involved in alcohol-induced cell death in vivo and in vitro. Bioscience, biotechnology, and biochemistry. 2020 Aug; 84(8):1621-1628. doi: 10.1080/09168451.2020.1763155. [PMID: 32419644]
  • Chunxiao Li, Lu Chen, Min Song, Zhirui Fang, Lusha Zhang, Joel Wake Coffie, Liyuan Zhang, Lulu Ma, Qianyi Wang, Wenjie Yang, Leyu Fang, Shaoxia Wang, Xiumei Gao, Hong Wang. Ferulic acid protects cardiomyocytes from TNF-α/cycloheximide-induced apoptosis by regulating autophagy. Archives of pharmacal research. 2020 Aug; 43(8):863-874. doi: 10.1007/s12272-020-01252-z. [PMID: 32720163]
  • Carolina Hassibe Thomé, Germano Aguiar Ferreira, Diego Antonio Pereira-Martins, Guilherme Augusto Dos Santos, César Alexander Ortiz, Lucas Eduardo Botelho de Souza, Lays Martins Sobral, Cleide Lúcia Araújo Silva, Priscila Santos Scheucher, Cristiane Damas Gil, Andréia Machado Leopoldino, Douglas R A Silveira, Juan L Coelho-Silva, Fabíola Traina, Luisa C Koury, Raul A M Melo, Rosane Bittencourt, Katia Pagnano, Ricardo Pasquini, Elenaide C Nunes, Evandro M Fagundes, Ana Beatriz F Gloria, Fábio Rodrigues Kerbauy, Maria de Lourdes Chauffaille, Armand Keating, Martin S Tallman, Raul C Ribeiro, Richard Dillon, Arnold Ganser, Bob Löwenberg, Peter Valk, Francesco Lo-Coco, Miguel A Sanz, Nancy Berliner, Vitor Marcel Faça, Eduardo M Rego. NTAL is associated with treatment outcome, cell proliferation and differentiation in acute promyelocytic leukemia. Scientific reports. 2020 06; 10(1):10315. doi: 10.1038/s41598-020-66223-2. [PMID: 32587277]
  • Xinbo Zhang, Cristina M Ramírez, Binod Aryal, Julio Madrigal-Matute, Xinran Liu, Antonio Diaz, Marta Torrecilla-Parra, Yajaira Suárez, Ana M Cuervo, William C Sessa, Carlos Fernández-Hernando. Cav-1 (Caveolin-1) Deficiency Increases Autophagy in the Endothelium and Attenuates Vascular Inflammation and Atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology. 2020 06; 40(6):1510-1522. doi: 10.1161/atvbaha.120.314291. [PMID: 32349535]
  • Yi-Ju Chou, Ching-Cheng Lin, Ivan Dzhagalov, Nien-Jung Chen, Chao-Hsiung Lin, Chun-Cheng Lin, Szu-Ting Chen, Kuo-Hsin Chen, Shu-Ling Fu. Vaccine adjuvant activity of a TLR4-activating synthetic glycolipid by promoting autophagy. Scientific reports. 2020 05; 10(1):8422. doi: 10.1038/s41598-020-65422-1. [PMID: 32439945]
  • Yuqing Kang, Yuebing Li, Heng Wen, Junfeng Zhu, Jiangbo Zheng, Zhaoming Feng. Prevention of renal ischemia and reperfusion injury by penehyclidine hydrochloride through autophagy activation. Molecular medicine reports. 2020 05; 21(5):2182-2192. doi: 10.3892/mmr.2020.11024. [PMID: 32186764]
  • Lin Xiaolong, Guo Dongmin, Mihua Liu, Wang Zuo, Hu Huijun, Tan Qiufen, Hu XueMei, Lin Wensheng, Pan Yuping, Lin Jun, Zeng Zhaolin. FGF21 induces autophagy-mediated cholesterol efflux to inhibit atherogenesis via RACK1 up-regulation. Journal of cellular and molecular medicine. 2020 05; 24(9):4992-5006. doi: 10.1111/jcmm.15118. [PMID: 32227589]
  • Anmao Li, Xingxin Li, Xuanxin Chen, Chensi Zeng, Zuo Wang, Zhen Li, Jianbin Chen. NUPR1 Silencing Induces Autophagy-Mediated Apoptosis in Multiple Myeloma Cells Through the PI3K/AKT/mTOR Pathway. DNA and cell biology. 2020 Mar; 39(3):368-378. doi: 10.1089/dna.2019.5196. [PMID: 31971825]
  • Yuzheng Zhou, Qianqian Zhang, Yangyang Kong, Xiaohong Guo, Haiyan Zhang, Huiqin Fan, Lixin Liu. Insulin-Like Growth Factor Binding Protein-Related Protein 1 Activates Primary Hepatic Stellate Cells via Autophagy Regulated by the PI3K/Akt/mTOR Signaling Pathway. Digestive diseases and sciences. 2020 02; 65(2):509-523. doi: 10.1007/s10620-019-05798-x. [PMID: 31468266]
  • Di Zhao, Yan Gao, Wei Wang, Hui Pei, Chunxiao Xu, Zhuo Zhao. PKD deletion promotes autophagy and inhibits hypertrophy in cardiomyocyte. Experimental cell research. 2020 01; 386(2):111742. doi: 10.1016/j.yexcr.2019.111742. [PMID: 31759056]
  • Xinxu Zhang, Yuanyuan Deng, Juan Xiang, Huixia Liu, Jiani Zhang, Jie Liao, Ke Chen, Bo Liu, Jun Liu, Ying Pu. Galangin Improved Non-Alcoholic Fatty Liver Disease in Mice by Promoting Autophagy. Drug design, development and therapy. 2020; 14(?):3393-3405. doi: 10.2147/dddt.s258187. [PMID: 32884242]
  • Yufei Cheng, Xudong Pan, Jing Wang, Xu Li, Shaonan Yang, Ruihua Yin, Aijun Ma, Xiaoyan Zhu. Fucoidan Inhibits NLRP3 Inflammasome Activation by Enhancing p62/SQSTM1-Dependent Selective Autophagy to Alleviate Atherosclerosis. Oxidative medicine and cellular longevity. 2020; 2020(?):3186306. doi: 10.1155/2020/3186306. [PMID: 33505579]
  • David S Enyart, Chelsea L Crocker, Jennifer R Stansell, Madeleine Cutrone, Meghann M Dintino, Stephen T Kinsey, Stephan L Brown, Bradley L Baumgarner. Low-dose caffeine administration increases fatty acid utilization and mitochondrial turnover in C2C12 skeletal myotubes. Physiological reports. 2020 01; 8(1):e14340. doi: 10.14814/phy2.14340. [PMID: 31960608]
  • Peng Zhang, Yong Li, Yingjie Fu, Lei Huang, Bailin Liu, Lubo Zhang, Xuesi M Shao, Daliao Xiao. Inhibition of Autophagy Signaling via 3-methyladenine Rescued Nicotine-Mediated Cardiac Pathological Effects and Heart Dysfunctions. International journal of biological sciences. 2020; 16(8):1349-1362. doi: 10.7150/ijbs.41275. [PMID: 32210724]
  • Hui Cao, Qingling Jia, Li Yan, Chuan Chen, Sanli Xing, Dingzhu Shen. Quercetin Suppresses the Progression of Atherosclerosis by Regulating MST1-Mediated Autophagy in ox-LDL-Induced RAW264.7 Macrophage Foam Cells. International journal of molecular sciences. 2019 Dec; 20(23):. doi: 10.3390/ijms20236093. [PMID: 31816893]
  • Yong-Bo Li, De-Zhou Cui, Xin-Xia Sui, Chen Huang, Cheng-Yan Huang, Qing-Qi Fan, Xiu-Sheng Chu. Autophagic Survival Precedes Programmed Cell Death in Wheat Seedlings Exposed to Drought Stress. International journal of molecular sciences. 2019 Nov; 20(22):. doi: 10.3390/ijms20225777. [PMID: 31744172]
  • Mai Shi, Shuang Yang, Xinwang Zhu, Da Sun, Dan Sun, Xue Jiang, Congxiao Zhang, Lining Wang. The RAGE/STAT5/autophagy axis regulates senescence in mesangial cells. Cellular signalling. 2019 10; 62(?):109334. doi: 10.1016/j.cellsig.2019.05.019. [PMID: 31158467]
  • Xiaofei Liang, Chao Wang, Yan Sun, Wei Song, Jing Lin, Jiashan Li, Xiuru Guan. p62/mTOR/LXRα pathway inhibits cholesterol efflux mediated by ABCA1 and ABCG1 during autophagy blockage. Biochemical and biophysical research communications. 2019 07; 514(4):1093-1100. doi: 10.1016/j.bbrc.2019.04.134. [PMID: 31101336]
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  • Barbara Bobrowska-Korczak, Paulina Gątarek, Angelina Rosiak, Joanna Giebułtowicz, Joanna Kałużna-Czaplińska. Reduced levels of modified nucleosides in the urine of autistic children. Preliminary studies. Analytical biochemistry. 2019 04; 571(?):62-67. doi: 10.1016/j.ab.2019.02.009. [PMID: 30771338]
  • Jui-Hu Shih, Chuang-Hsin Chiu, Kuo-Hsing Ma, Yuahn-Sieh Huang, Chyng-Yann Shiue, Ting-Yin Yeh, Li-Ting Kao, Yang-Yi Lin, I-Hsun Li. Autophagy inhibition plays a protective role against 3, 4-methylenedioxymethamphetamine (MDMA)-induced loss of serotonin transporters and depressive-like behaviors in rats. Pharmacological research. 2019 04; 142(?):283-293. doi: 10.1016/j.phrs.2019.02.026. [PMID: 30826457]
  • Li-Hua Cui, Cai-Xia Li, Yu-Zhen Zhuo, Lei Yang, Nai-Qiang Cui, Shu-Kun Zhang. Saikosaponin d ameliorates pancreatic fibrosis by inhibiting autophagy of pancreatic stellate cells via PI3K/Akt/mTOR pathway. Chemico-biological interactions. 2019 Feb; 300(?):18-26. doi: 10.1016/j.cbi.2019.01.005. [PMID: 30611790]
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  • Bing-Xin Chu, Rui-Feng Fan, Shu-Qian Lin, Du-Bao Yang, Zhen-Yong Wang, Lin Wang. Interplay between autophagy and apoptosis in lead(II)-induced cytotoxicity of primary rat proximal tubular cells. Journal of inorganic biochemistry. 2018 05; 182(?):184-193. doi: 10.1016/j.jinorgbio.2018.02.015. [PMID: 29501979]
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