Tryptamine (BioDeep_00000399993)

Main id: BioDeep_00000000123

 

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


5-22-10-00045 (Beilstein Handbook Reference)

化学式: C10H12N2 (160.1000432)
中文名称: 色胺
谱图信息: 最多检出来源 Homo sapiens(blood) 3.68%

分子结构信息

SMILES: C1=CC=C2C(=C1)C(=CN2)CCN
InChI: InChI=1S/C10H12N2/c11-6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6,11H2

描述信息

同义名列表

54 个代谢物同义名

5-22-10-00045 (Beilstein Handbook Reference); (Amino-2 ethyl)-3 indole [French]; 2-(1H-indol-3-yl)ethylamine; 2-(1H-Indol-3-yl)ethanamine; Indole, 3-(2-aminoethyl)-; 2-(Indol-3-yl)ethylamine; 2-(3-Indolyl)ethylamine; 1H-Indole-3-ethanamine; 2-Indol-3-ylethylamine; 3-(2-aminoethyl)indole; SDCCGMLS-0066798.P001; Indol-3-ethylamine; Spectrum5_001296; EINECS 200-510-5; Spectrum2_000873; Spectrum3_001890; Spectrum4_000850; NCGC00095081-04; SPECTRUM1503922; NCGC00095081-01; AE-848\30735051; NCGC00014994-01; NCGC00095081-02; Spectrum_000033; 193747_ALDRICH; KBioSS_000393; Oprea1_870097; BSPBio_003400; Lopac0_000061; KBioGR_001459; DivK1c_000862; KBio2_000393; SPBio_000945; KBio2_002961; KBio1_000862; MLS000515794; Lopac-246557; SMR000112268; KBio3_002903; KBio2_005529; NINDS_000862; AIDS-072303; BRN 0125513; CHEBI:16765; IDI1_000862; AIDS072303; Tryptamine; SBB003963; 61-54-1; C00398; TSH; MT4; TSS; Tryptmanine



数据库引用编号

51 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

53 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Lei-Qi Liu, Jing-Ze Chen, Wu-Sheng Fu, Cui-Ying Tang. [Determination of amanita peptide and tryptamine toxins in wild mushrooms by high performance liquid chromatography-tandem mass spectrometry]. Se pu = Chinese journal of chromatography. 2023 Nov; 41(11):976-985. doi: 10.3724/sp.j.1123.2023.07013. [PMID: 37968816]
  • Daijing Wei, Yun Yang, Ruiying Xi, Yunqing He, Ighodaro Igbe, Fei Wang, Guolin Zhang, Yinggang Luo. Hunteriasines A - D, tryptamine-derived alkaloids from Hunteria umbellata. Phytochemistry. 2023 Sep; 213(?):113752. doi: 10.1016/j.phytochem.2023.113752. [PMID: 37330032]
  • Lixiang Zhai, Haitao Xiao, Chengyuan Lin, Hoi Leong Xavier Wong, Yan Y Lam, Mengxue Gong, Guojun Wu, Ziwan Ning, Chunhua Huang, Yijing Zhang, Chao Yang, Jingyuan Luo, Lu Zhang, Ling Zhao, Chenhong Zhang, Johnson Yiu-Nam Lau, Aiping Lu, Lok-Ting Lau, Wei Jia, Liping Zhao, Zhao-Xiang Bian. Gut microbiota-derived tryptamine and phenethylamine impair insulin sensitivity in metabolic syndrome and irritable bowel syndrome. Nature communications. 2023 Aug; 14(1):4986. doi: 10.1038/s41467-023-40552-y. [PMID: 37591886]
  • Jie Chen, Yueqi Zhang, Huanran Yin, Wei Liu, Xin Hu, Dongqin Li, Caixia Lan, Lifeng Gao, Zhonghu He, Fa Cui, Alisdair R Fernie, Wei Chen. The pathway of melatonin biosynthesis in common wheat (Triticum aestivum). Journal of pineal research. 2023 Mar; 74(2):e12841. doi: 10.1111/jpi.12841. [PMID: 36396897]
  • Fateme Zohairi, Himanshu Khandelia, Ali Asghar Hakami Zanjani. Interaction of psychedelic tryptamine derivatives with a lipid bilayer. Chemistry and physics of lipids. 2023 Mar; 251(?):105279. doi: 10.1016/j.chemphyslip.2023.105279. [PMID: 36627076]
  • Marcus Daniel Brandbjerg Bohn Lorensen, Nanna Bjarnholt, Benoit St-Pierre, Vincent Courdavault, Sarah Heinicke, Sarah O'Connor, Christian Janfelt. Spatial localization of monoterpenoid indole alkaloids in Rauvolfia tetraphylla by high resolution mass spectrometry imaging. Phytochemistry. 2023 Feb; ?(?):113620. doi: 10.1016/j.phytochem.2023.113620. [PMID: 36863602]
  • Lea Wagmann, Sascha K Manier, Markus R Meyer. Can the Intake of a Synthetic Tryptamine be Detected Only by Blood Plasma Analysis? A Clinical Toxicology Case Involving 4-HO-MET. Journal of analytical toxicology. 2022 May; 46(5):567-572. doi: 10.1093/jat/bkab062. [PMID: 34100553]
  • Rajasree G Krishnan, Beena Saraswathyamma. Murexide-derived in vitro electrochemical sensor for the simultaneous determination of neurochemicals. Analytical and bioanalytical chemistry. 2021 Nov; 413(27):6803-6812. doi: 10.1007/s00216-021-03282-y. [PMID: 33774711]
  • Jiahui Shao, Yucong Li, Zunfeng Li, Zhihui Xu, Weibing Xun, Nan Zhang, Haichao Feng, Youzhi Miao, Qirong Shen, Ruifu Zhang. Participating mechanism of a major contributing gene ysnE for auxin biosynthesis in Bacillus amyloliquefaciens SQR9. Journal of basic microbiology. 2021 Jun; 61(6):569-575. doi: 10.1002/jobm.202100098. [PMID: 33914927]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Sascha K Manier, Christina Felske, Josef Zapp, Niels Eckstein, Markus R Meyer. Studies on the In Vitro and In Vivo Metabolic Fate of the New Psychoactive Substance N-Ethyl-N-Propyltryptamine for Analytical Purposes. Journal of analytical toxicology. 2021 Feb; 45(2):195-202. doi: 10.1093/jat/bkaa060. [PMID: 32507893]
  • Peisen Su, Lanfei Zhao, Wen Li, Jinxiao Zhao, Jun Yan, Xin Ma, Anfei Li, Hongwei Wang, Lingrang Kong. Integrated metabolo-transcriptomics and functional characterization reveals that the wheat auxin receptor TIR1 negatively regulates defense against Fusarium graminearum. Journal of integrative plant biology. 2021 Feb; 63(2):340-352. doi: 10.1111/jipb.12992. [PMID: 32678930]
  • Dagang Tian, Fang Yang, Yuqing Niu, Yan Lin, Zaijie Chen, Gang Li, Qiong Luo, Feng Wang, Mo Wang. Loss function of SL (sekiguchi lesion) in the rice cultivar Minghui 86 leads to enhanced resistance to (hemi)biotrophic pathogens. BMC plant biology. 2020 Nov; 20(1):507. doi: 10.1186/s12870-020-02724-6. [PMID: 33148178]
  • Analía A Gomez, Zareath P Terán Baptista, Tsvetelina Mandova, Angeliki Barouti, Marina Kritsanida, Raphaël Grougnet, Marta A Vattuone, Diego A Sampietro. Antifungal and antimycotoxigenic metabolites from native plants of northwest Argentina: isolation, identification and potential for control of Aspergillus species. Natural product research. 2020 Nov; 34(22):3299-3302. doi: 10.1080/14786419.2018.1560286. [PMID: 30663391]
  • Jyoti Singh Jadaun, Amit Kumar Kushwaha, Neelam S Sangwan, Lokesh Kumar Narnoliya, Smrati Mishra, Rajender Singh Sangwan. WRKY1-mediated regulation of tryptophan decarboxylase in tryptamine generation for withanamide production in Withania somnifera (Ashwagandha). Plant cell reports. 2020 Nov; 39(11):1443-1465. doi: 10.1007/s00299-020-02574-4. [PMID: 32789542]
  • Janis Fricke, Robert Kargbo, Lars Regestein, Claudius Lenz, Gundela Peschel, Miriam A Rosenbaum, Alexander Sherwood, Dirk Hoffmeister. Scalable Hybrid Synthetic/Biocatalytic Route to Psilocybin. Chemistry (Weinheim an der Bergstrasse, Germany). 2020 Jul; 26(37):8281-8285. doi: 10.1002/chem.202000134. [PMID: 32101345]
  • Hana Leontovyčová, Lucie Trdá, Petre Ivanov Dobrev, Vladimír Šašek, Elise Gay, Marie-Hélène Balesdent, Lenka Burketová. Auxin biosynthesis in the phytopathogenic fungus Leptosphaeria maculans is associated with enhanced transcription of indole-3-pyruvate decarboxylase LmIPDC2 and tryptophan aminotransferase LmTAM1. Research in microbiology. 2020 Jul; 171(5-6):174-184. doi: 10.1016/j.resmic.2020.05.001. [PMID: 32540203]
  • Xiaohong Fan, Junfang Li, Xuemei Deng, Yingmei Lu, Yiyue Feng, Shumeng Ma, Huaixiu Wen, Quanyi Zhao, Wen Tan, Tao Shi, Zhen Wang. Design, synthesis and bioactivity study of N-salicyloyl tryptamine derivatives as multifunctional agents for the treatment of neuroinflammation. European journal of medicinal chemistry. 2020 May; 193(?):112217. doi: 10.1016/j.ejmech.2020.112217. [PMID: 32182488]
  • Xiwen Tong, Yundan Wang, Pengcheng Yang, Chengshu Wang, Le Kang. Tryptamine accumulation caused by deletion of MrMao-1 in Metarhizium genome significantly enhances insecticidal virulence. PLoS genetics. 2020 04; 16(4):e1008675. doi: 10.1371/journal.pgen.1008675. [PMID: 32271756]
  • Brian G O'Flynn, Eric M Lewandowski, Karin Claire Prins, Gabriela Suarez, Angelica N McCaskey, Nasha M Rios-Guzman, Ryan L Anderson, Britney A Shepherd, Ioannis Gelis, James W Leahy, Yu Chen, David J Merkler. Characterization of Arylalkylamine N-Acyltransferase from Tribolium castaneum: An Investigation into a Potential Next-Generation Insecticide Target. ACS chemical biology. 2020 02; 15(2):513-523. doi: 10.1021/acschembio.9b00973. [PMID: 31967772]
  • Jakub Staroń, Rafał Kurczab, Dawid Warszycki, Grzegorz Satała, Martyna Krawczyk, Ryszard Bugno, Tomasz Lenda, Piotr Popik, Adam S Hogendorf, Agata Hogendorf, Krzysztof Dubiel, Mikołaj Matłoka, Rafał Moszczyński-Pętkowski, Jerzy Pieczykolan, Maciej Wieczorek, Paweł Zajdel, Andrzej J Bojarski. Virtual screening-driven discovery of dual 5-HT6/5-HT2A receptor ligands with pro-cognitive properties. European journal of medicinal chemistry. 2020 Jan; 185(?):111857. doi: 10.1016/j.ejmech.2019.111857. [PMID: 31734022]
  • Yang Yu, Mei-Fen Bao, Jing Wu, Jing Chen, Yu-Rong Yang, Johann Schinnerl, Xiang-Hai Cai. Tabernabovines A-C: Three Monoterpenoid Indole Alkaloids from the Leaves of Tabernaemontana bovina. Organic letters. 2019 08; 21(15):5938-5942. doi: 10.1021/acs.orglett.9b02060. [PMID: 31294995]
  • Alma Vázquez-Luna, Fabio García-García, Diana I Caudillo Contreras, Eduardo Rivadeneyra-Domínguez, Rafael Díaz-Sobac. Effect of orange juice and tryptamine on the behavior and c-fos expression of Wistar rats. Metabolic brain disease. 2019 04; 34(2):519-525. doi: 10.1007/s11011-018-0365-5. [PMID: 30604026]
  • Mauro Commisso, Stefano Negri, Martino Bianconi, Sofia Gambini, Sara Avesani, Stefania Ceoldo, Linda Avesani, Flavia Guzzo. Untargeted and Targeted Metabolomics and Tryptophan Decarboxylase In Vivo Characterization Provide Novel Insight on the Development of Kiwifruits (Actinidia deliciosa). International journal of molecular sciences. 2019 Feb; 20(4):. doi: 10.3390/ijms20040897. [PMID: 30791398]
  • Tiantian Ye, Xiaoming Yin, Lei Yu, Shu-Jian Zheng, Wen-Jing Cai, Yan Wu, Yu-Qi Feng. Metabolic analysis of the melatonin biosynthesis pathway using chemical labeling coupled with liquid chromatography-mass spectrometry. Journal of pineal research. 2019 Jan; 66(1):e12531. doi: 10.1111/jpi.12531. [PMID: 30299556]
  • Brian Torres, James S Tyler, Kenneth A Satyshur, Arnold E Ruoho. Human indole(ethyl)amine-N-methyltransferase (hINMT) catalyzed methylation of tryptamine, dimethylsulfide and dimethylselenide is enhanced under reducing conditions - A comparison between 254C and 254F, two common hINMT variants. PloS one. 2019; 14(7):e0219664. doi: 10.1371/journal.pone.0219664. [PMID: 31310642]
  • Felix Blei, Janis Fricke, Jonas Wick, Jason C Slot, Dirk Hoffmeister. Iterative l-Tryptophan Methylation in Psilocybe Evolved by Subdomain Duplication. Chembiochem : a European journal of chemical biology. 2018 10; 19(20):2160-2166. doi: 10.1002/cbic.201800336. [PMID: 30098085]
  • Geofrey Sing'ombe Ombiro, Taku Sawai, Yoshiteru Noutoshi, Yuta Nishina, Hidenori Matsui, Mikihiro Yamamoto, Kazuhiro Toyoda, Yuki Ichinose. Specific growth inhibitors of Ralstonia solanacearum, Xanthomonas oryzae pv. oryzae, X. campestris pv. campestris, and Clavibacter michiganensis subsp. michiganensis. Microbiological research. 2018 Oct; 215(?):29-35. doi: 10.1016/j.micres.2018.06.005. [PMID: 30172306]
  • Desiree Pressnitz, Eva-Maria Fischereder, Jakob Pletz, Christina Kofler, Lucas Hammerer, Katharina Hiebler, Horst Lechner, Nina Richter, Elisabeth Eger, Wolfgang Kroutil. Asymmetric Synthesis of (R)-1-Alkyl-Substituted Tetrahydro-ß-carbolines Catalyzed by Strictosidine Synthases. Angewandte Chemie (International ed. in English). 2018 08; 57(33):10683-10687. doi: 10.1002/anie.201803372. [PMID: 29852524]
  • Yang Yu, Yan Lv, Yana Shi, Tao Li, Yanchun Chen, Dake Zhao, Zhiwei Zhao. The Role of Phyto-Melatonin and Related Metabolites in Response to Stress. Molecules (Basel, Switzerland). 2018 Jul; 23(8):. doi: 10.3390/molecules23081887. [PMID: 30060559]
  • Yogesh Bhattarai, Brianna B Williams, Eric J Battaglioli, Weston R Whitaker, Lisa Till, Madhusudan Grover, David R Linden, Yasutada Akiba, Karunya K Kandimalla, Nicholas C Zachos, Jonathan D Kaunitz, Justin L Sonnenburg, Michael A Fischbach, Gianrico Farrugia, Purna C Kashyap. Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion. Cell host & microbe. 2018 06; 23(6):775-785.e5. doi: 10.1016/j.chom.2018.05.004. [PMID: 29902441]
  • Chris Dockendorff, Disha M Gandhi, Ian H Kimball, Kenneth S Eum, Radda Rusinova, Helgi I Ingólfsson, Ruchi Kapoor, Thasin Peyear, Matthew W Dodge, Stephen F Martin, Richard W Aldrich, Olaf S Andersen, Jon T Sack. Synthetic Analogues of the Snail Toxin 6-Bromo-2-mercaptotryptamine Dimer (BrMT) Reveal That Lipid Bilayer Perturbation Does Not Underlie Its Modulation of Voltage-Gated Potassium Channels. Biochemistry. 2018 05; 57(18):2733-2743. doi: 10.1021/acs.biochem.8b00292. [PMID: 29616558]
  • Smitha Krishnan, Yufang Ding, Nima Saedi, Maria Choi, Gautham V Sridharan, David H Sherr, Martin L Yarmush, Robert C Alaniz, Arul Jayaraman, Kyongbum Lee. Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages. Cell reports. 2018 04; 23(4):1099-1111. doi: 10.1016/j.celrep.2018.03.109. [PMID: 29694888]
  • Jan Honegr, Rafael Dolezal, David Malinak, Marketa Benkova, Ondrej Soukup, Joyce S F D de Almeida, Tanos C C Franca, Kamil Kuca, Roman Prymula. Rational Design of a New Class of Toll-Like Receptor 4 (TLR4) Tryptamine Related Agonists by Means of the Structure- and Ligand-Based Virtual Screening for Vaccine Adjuvant Discovery. Molecules (Basel, Switzerland). 2018 Jan; 23(1):. doi: 10.3390/molecules23010102. [PMID: 29300367]
  • Achim T Caspar, Jonas B Gaab, Julian A Michely, Simon D Brandt, Markus R Meyer, Hans H Maurer. Metabolism of the tryptamine-derived new psychoactive substances 5-MeO-2-Me-DALT, 5-MeO-2-Me-ALCHT, and 5-MeO-2-Me-DIPT and their detectability in urine studied by GC-MS, LC-MSn , and LC-HR-MS/MS. Drug testing and analysis. 2018 Jan; 10(1):184-195. doi: 10.1002/dta.2197. [PMID: 28342193]
  • Abhishek Sharma, Priyanka Verma, Archana Mathur, Ajay Kumar Mathur. Genetic engineering approach using early Vinca alkaloid biosynthesis genes led to increased tryptamine and terpenoid indole alkaloids biosynthesis in differentiating cultures of Catharanthus roseus. Protoplasma. 2018 Jan; 255(1):425-435. doi: 10.1007/s00709-017-1151-7. [PMID: 28808798]
  • Andreas Berger, Elias Tanuhadi, Lothar Brecker, Johann Schinnerl, Karin Valant-Vetschera. Chemodiversity of tryptamine-derived alkaloids in six Costa Rican Palicourea species (Rubiaceae-Palicoureeae). Phytochemistry. 2017 Nov; 143(?):124-131. doi: 10.1016/j.phytochem.2017.07.016. [PMID: 28806604]
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