N-Methyl-D-aspartic acid (BioDeep_00000399922)
natural product BioNovoGene_Lab2019
代谢物信息卡片
N-Methyl-D-aspartic acid
化学式: C5H9NO4 (147.0532)
中文名称: N-甲基-D-天冬氨酸水合物, N-甲基-D-天冬氨酸
谱图信息:
最多检出来源 Ferula hexiensis(natural_products) 100%
分子结构信息
SMILES: CNC(CC(=O)O)C(=O)O
InChI: InChI=1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/t3-/m1/s1
描述信息
D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018690 - Excitatory Amino Acid Agonists
同义名列表
2 个代谢物同义名
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:31882
- PubChem: 22880
- ChEMBL: CHEMBL291278
- MeSH: N-Methylaspartate
- CAS: 6384-92-5
- MoNA: CCMSLIB00005720403
- MoNA: CCMSLIB00005720696
- MoNA: EMBL-MCF_spec115434
- MoNA: EMBL-MCF_spec43911
- MoNA: MoNA001838
- MoNA: MoNA001837
- MoNA: MoNA001836
- MoNA: HMDB0002393_ms_ms_2099
- MoNA: HMDB0002393_ms_ms_2098
- MoNA: HMDB0002393_ms_ms_2100
- MoNA: CCMSLIB00000577964
- RefMet: N-Methyl-D-aspartic acid
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-166
分类词条
相关代谢途径
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jiaojiao Wang, Abolfazl Akbari, Marjan Chardahcherik, Jun Wu. Ginger (Zingiber Officinale Roscoe) ameliorates ethanol-induced cognitive impairment by modulating NMDA and GABA-A receptors in rat hippocampus.
Metabolic brain disease.
2023 Nov; ?(?):. doi:
10.1007/s11011-023-01301-8. [PMID: 37966694] - Han Shuai, Mao Hua, Jin Tingting, Yan Rubing, Wang Ziyi, Zhang Jie, Shi Jianwen, Liang Yongxin. Inhibitory effect of berberine on morphine tolerance and hyperalgesia in mice.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2023 10; 43(5):915-924. doi:
10.19852/j.cnki.jtcm.20230802.006. [PMID: 37679979] - Dmitry A Sibarov, Zoia D Zhuravleva, Margarita A Ilina, Sergei I Boikov, Yulia D Stepanenko, Tatiana V Karelina, Sergei M Antonov. Unveiling the Role of Cholesterol in Subnanomolar Ouabain Rescue of Cortical Neurons from Calcium Overload Caused by Excitotoxic Insults.
Cells.
2023 08; 12(15):. doi:
10.3390/cells12152011. [PMID: 37566090] - Mohammad Keimasi, Kowsar Salehifard, Sayyed Jafar Hoseini, Fariba Esmaeili, Noushin Mirshah Jafar Esfahani, Mohammadreza Amirsadri, Mohammadjavad Keimasi, Majid Moradmand, Mohammad Reza Mofid. Purified Native Protein Extracted from the Venom of Agelena orientalis Attenuates Memory Defects in the Rat Model of Glutamate-Induced Excitotoxicity.
The protein journal.
2023 Aug; ?(?):. doi:
10.1007/s10930-023-10140-6. [PMID: 37531037] - Weronika Krzeszowiec, Aleksandra Lewandowska, Jan Jakub Lyczakowski, Kateryna Bebko, Sandra S Scholz, Halina Gabryś. Two types of GLR channels cooperate differently in light and dark growth of Arabidopsis seedlings.
BMC plant biology.
2023 Jul; 23(1):358. doi:
10.1186/s12870-023-04367-9. [PMID: 37442951] - Kenan Yıldızhan, Mustafa Nazıroğlu. NMDA Receptor Activation Stimulates Hypoxia-Induced TRPM2 Channel Activation, Mitochondrial Oxidative Stress, and Apoptosis in Neuronal Cell Line: Modular Role of Memantine.
Brain research.
2023 Mar; 1803(?):148232. doi:
10.1016/j.brainres.2023.148232. [PMID: 36610553] - Afiqq Aiman B Abd Ghapor, Nurul Alimah Abdul Nasir, Igor Iezhitsa, Renu Agarwal, Norhafiza Razali. Neuroprotection by trans-resveratrol in rats with N-methyl-D-aspartate (NMDA)-induced retinal injury: insights into the role of adenosine A1 receptors.
Neuroscience research.
2023 Feb; ?(?):. doi:
10.1016/j.neures.2023.02.004. [PMID: 36796452] - Ming Gao, Yi Wu, Lishou Yang, Faju Chen, Liangqun Li, Qiji Li, Yu Wang, Lilang Li, Mei Peng, Yanfang Yan, Juan Yang, Xiaosheng Yang. Anti-depressant-like effect of fermented Gastrodia elata Bl. by regulating monoamine levels and BDNF/NMDAR pathways in mice.
Journal of ethnopharmacology.
2023 Jan; 301(?):115832. doi:
10.1016/j.jep.2022.115832. [PMID: 36283636] - Wenda Zhu, Yiping Fan, Yanbing Li, Lizhi Peng, Yifang Li, Fengxia Yan, Jiaqiang Zhao, Lei Zhang, Hiroshi Kurihara, Rongrong He, Heru Chen. Hybridization of amantadine with gardenamide A enhances NMDA antagonism and in vivo anti-PD effects.
Bioorganic chemistry.
2023 01; 130(?):106223. doi:
10.1016/j.bioorg.2022.106223. [PMID: 36356372] - Xiao-Hong Li, Jie-Jun Fu, Xiao-Juan Shi, Yun-Na Zhang, Min Shao, Shao-Jie Yue, Chen Li, Zi-Qiang Luo. Sp1 mediated the inhibitory effect of glutamate on pulmonary surfactant synthesis.
PloS one.
2023; 18(8):e0289530. doi:
10.1371/journal.pone.0289530. [PMID: 37556489] - Faju Chen, Li Wang, Fengli Jin, Liangqun Li, Tao Wang, Ming Gao, Lilang Li, Yu Wang, Zhongsheng Lou, Juan Yang, Qiji Li, Xiaosheng Yang. Neuroprotection of Kaji-Ichigoside F1 via the BDNF/Akt/mTOR Signaling Pathways against NMDA-Induced Neurotoxicity.
International journal of molecular sciences.
2022 Dec; 23(24):. doi:
10.3390/ijms232416150. [PMID: 36555790] - Meixi He, Yingang Feng, Yi Wang, Mengchun Cheng, Xiaozhe Zhang, Lihua Zhang. Discovery of a cysteine-rich peptide with glycation modification from Achyranthes bidentata Blume.
Fitoterapia.
2022 Nov; 163(?):105338. doi:
10.1016/j.fitote.2022.105338. [PMID: 36270560] - Haiying Guan, Ting Yan, Dongyang Wu, Alok Shiomurti Tripathi. Epifriedelinol Ameliorates the Neuropathic Pain and Recovers the Function in Spinal Cord Injury by Downregulation of Neuronal Apoptosis and NMDA Receptor.
The Tohoku journal of experimental medicine.
2022 Sep; 258(2):143-148. doi:
10.1620/tjem.2022.j065. [PMID: 35965095] - Timothy A Troppoli, Panos Zanos, Polymnia Georgiou, Todd D Gould, Uwe Rudolph, Scott M Thompson. Negative Allosteric Modulation of Gamma-Aminobutyric Acid A Receptors at α5 Subunit-Containing Benzodiazepine Sites Reverses Stress-Induced Anhedonia and Weakened Synaptic Function in Mice.
Biological psychiatry.
2022 08; 92(3):216-226. doi:
10.1016/j.biopsych.2021.11.024. [PMID: 35120711] - Afiqq Aiman Abd Ghapor, Igor Iezhitsa, Renu Agarwal, Nurul Alimah Abdul Nasir. Intravitreal Trans-Resveratrol Ameliorates NMDA-Induced Optic Nerve and Retinal Injury.
Current eye research.
2022 Jun; 47(6):866-873. doi:
10.1080/02713683.2022.2033270. [PMID: 35188034] - Yasunori Iwata, Yusuke Nakade, Shinji Kitajima, Shiori Yoneda-Nakagawa, Megumi Oshima, Norihiko Sakai, Hisayuki Ogura, Koichi Sato, Tadashi Toyama, Yuta Yamamura, Taro Miyagawa, Hiroka Yamazaki, Akinori Hara, Miho Shimizu, Kengo Furuichi, Masashi Mita, Kenji Hamase, Tomohiro Tanaka, Motohiro Nishida, Wataru Muramatsu, Hisashi Yamamoto, Shigeyuki Shichino, Satoshi Ueha, Kouji Matsushima, Takashi Wada. Protective effect of d-alanine against acute kidney injury.
American journal of physiology. Renal physiology.
2022 06; 322(6):F667-F679. doi:
10.1152/ajprenal.00198.2021. [PMID: 35435002] - Tung-Hsia Liu, Hsiao-Hui Tsou, Ren-Hua Chung, Shu Chih Liu, Sheng-Chang Wang, Hsiang-Wei Kuo, Chiu-Ping Fang, Andrew C H Chen, Yu-Li Liu. Association of the D-amino acid oxidase gene with methadone dose in heroin dependent patients under methadone maintenance treatment.
Journal of human genetics.
2022 May; 67(5):273-278. doi:
10.1038/s10038-021-01008-7. [PMID: 34983973] - Amy Kunchok, Andrew McKeon, Anastasia Zekeridou, Eoin P Flanagan, Divyanshu Dubey, Vanda A Lennon, Christopher J Klein, John R Mills, Sean J Pittock. Autoimmune/Paraneoplastic Encephalitis Antibody Biomarkers: Frequency, Age, and Sex Associations.
Mayo Clinic proceedings.
2022 03; 97(3):547-559. doi:
10.1016/j.mayocp.2021.07.023. [PMID: 34955239] - Mette Scheller Nissen, Maren Synnøve Ørvik, Anna Christine Nilsson, Matias Ryding, Magnus Lydolph, Morten Blaabjerg. NMDA-receptor encephalitis in Denmark from 2009 to 2019: a national cohort study.
Journal of neurology.
2022 Mar; 269(3):1618-1630. doi:
10.1007/s00415-021-10738-9. [PMID: 34351472] - Steven L Gonias, Michael A Banki, Pardis Azmoon, Haylie K Romero, Christina J Sigurdson, Elisabetta Mantuano, Wendy M Campana. Cellular prion protein in human plasma-derived extracellular vesicles promotes neurite outgrowth via the NMDA receptor-LRP1 receptor system.
The Journal of biological chemistry.
2022 03; 298(3):101642. doi:
10.1016/j.jbc.2022.101642. [PMID: 35090893] - Iryna Ivanivna Kamyshna, Larysa Borysivna Pavlovych, Aleksandr Mychailovich Kamyshnyi. Association between NMDA gene polymorphism (rs4880213) and GRIN2B blood serum levels in thyroid pathology patients.
Journal of medicine and life.
2022 Jan; 15(1):109-116. doi:
10.25122/jml-2021-0372. [PMID: 35186144] - Libor Uttl, Tomáš Hložek, Pavel Mareš, Tomáš Páleníček, Hana Kubová. Anticonvulsive Effects and Pharmacokinetic Profile of Cannabidiol (CBD) in the Pentylenetetrazol (PTZ) or N-Methyl-D-Aspartate (NMDA) Models of Seizures in Infantile Rats.
International journal of molecular sciences.
2021 Dec; 23(1):. doi:
10.3390/ijms23010094. [PMID: 35008517] - J W Liao, P Ma, H H Yang, J Y Pan. [mRNA level of N-methyl-D-aspartic acid receptor NR1 subunit in patients with major depressive disorder and its relationship with clinical features].
Zhonghua yi xue za zhi.
2021 Oct; 101(39):3227-3231. doi:
10.3760/cma.j.cn112137-20210306-00573. [PMID: 34689535] - Qiang Gao, Dan-Feng Tian, Dan-Dan Zhang, Yang-Yang Guo, Jing-Feng Lin, Gan-Lu Liu, Ze Chang, Yu-Chun Wang, Zhen-Yun Han. Tongluo Huatan capsule improves cognitive function by regulating the endocytosis of N-methyl-D-aspartic acid receptors mediated by clathrin in a rat model of vascular dementia.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2021 10; 41(5):771-778. doi:
10.19852/j.cnki.jtcm.2021.05.011. [PMID: 34708636] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Clara Woods, Jose Marques-Lopes, Natalina H Contoreggi, Teresa A Milner, Virginia M Pickel, Gang Wang, Michael J Glass. Tumor Necrosis Factor α Receptor Type 1 Activation in the Hypothalamic Paraventricular Nucleus Contributes to Glutamate Signaling and Angiotensin II-Dependent Hypertension.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2021 02; 41(6):1349-1362. doi:
10.1523/jneurosci.2360-19.2020. [PMID: 33303682] - Neeru M Sharma, Andréa S Haibara, Kenichi Katsurada, Shyam S Nandi, Xuefei Liu, Hong Zheng, Kaushik P Patel. Central Ang II (Angiotensin II)-Mediated Sympathoexcitation: Role for HIF-1α (Hypoxia-Inducible Factor-1α) Facilitated Glutamatergic Tone in the Paraventricular Nucleus of the Hypothalamus.
Hypertension (Dallas, Tex. : 1979).
2021 01; 77(1):147-157. doi:
10.1161/hypertensionaha.120.16002. [PMID: 33296248] - Gollapalle Lakshminarayanashastry Viswanatha, Hanumanthappa Shylaja, Darisi Venkata Kishore, Marikunte V Venkataranganna, Nunna Bheema Lingeswara Prasad. Acteoside Isolated from Colebrookea oppositifolia Smith Attenuates Epilepsy in Mice Via Modulation of Gamma-Aminobutyric Acid Pathways.
Neurotoxicity research.
2020 Dec; 38(4):1010-1023. doi:
10.1007/s12640-020-00267-0. [PMID: 32803629] - Pavel Montes de Oca Balderas, Mauricio Matus Núñez, Arturo Picones, Arturo Hernández-Cruz. NMDAR in cultured astrocytes: Flux-independent pH sensor and flux-dependent regulator of mitochondria and plasma membrane-mitochondria bridging.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2020 12; 34(12):16622-16644. doi:
10.1096/fj.202001300r. [PMID: 33131132] - Yue Yang, Lingyue Gao, Yixuan Niu, Xiang Li, Wenwu Liu, Xiaowen Jiang, Yaqian Liu, Qingchun Zhao. Kukoamine A Protects against NMDA-Induced Neurotoxicity Accompanied with Down-Regulation of GluN2B-Containing NMDA Receptors and Phosphorylation of PI3K/Akt/GSK-3β Signaling Pathway in Cultured Primary Cortical Neurons.
Neurochemical research.
2020 Nov; 45(11):2703-2711. doi:
10.1007/s11064-020-03114-y. [PMID: 32892226] - Indre Lapeikaite, Vilmantas Pupkis, Vladas Neniskis, Osvaldas Ruksenas, Vilma Kisnieriene. Glutamate and NMDA affect cell excitability and action potential dynamics of single cell of macrophyte Nitellopsis obtusa.
Functional plant biology : FPB.
2020 11; 47(12):1032-1040. doi:
10.1071/fp20074. [PMID: 33213696] - Haipeng Cheng, Qingmei Cheng, Xingwen Bao, Yongyu Luo, Yan Zhou, Yanghang Li, Qingzhong Hua, Wei Liu, Siyuan Tang, Dandan Feng, Ziqiang Luo. Over-activation of NMDA receptors promotes ABCA1 degradation and foam cell formation.
Biochimica et biophysica acta. Molecular and cell biology of lipids.
2020 10; 1865(10):158778. doi:
10.1016/j.bbalip.2020.158778. [PMID: 32745694] - Alice Franchi, Marco Pedrazzi, Alessandro Alberto Casazza, Enrico Millo, Gianluca Damonte, Annalisa Salis, Nara Liessi, Franco Onofri, Antonella Marte, Silvia Casagrande, Roberta De Tullio, Patrizia Perego, Monica Averna. A Bioactive Olive Pomace Extract Prevents the Death of Murine Cortical Neurons Triggered by NMDAR Over-Activation.
Molecules (Basel, Switzerland).
2020 09; 25(19):. doi:
10.3390/molecules25194385. [PMID: 32987671] - Wei-Ting Liu, Meng-Hong Jiang, Zhi-Fu Wang, Mei-Feng Zheng, Xiao-Mei Chen, Liang-Ping Zhang, Sheng-Xiang Liang, Xiang-Mei Yu. [Effect of wrist-ankle acupuncture on the expression of glutamate and NMDA receptor of the spinal dorsal horn in rats with neuropathic pain].
Zhen ci yan jiu = Acupuncture research.
2020 Aug; 45(8):623-7. doi:
10.13702/j.1000-0607.190794. [PMID: 32869571] - Santosh Rijal, Dong Hyu Cho, Seon-Ah Park, Seon Hui Jang, István M Ábrahám, Seong Kyu Han. Melatonin Suppresses the Kainate Receptor-Mediated Excitation on Gonadotropin-Releasing Hormone Neurons in Female and Male Prepubertal Mice.
International journal of molecular sciences.
2020 Aug; 21(17):. doi:
10.3390/ijms21175991. [PMID: 32825350] - Hailou Zhang, Yan Sun, Shiyu Qian, Rui Ge, Xiaoyan Guo, Qinqin Shen, Li Sheng, Chunying Nie, Yi Zhang, Yao Yao, Tong Zhou, Wei Wang, Wenda Xue, Gang Chen. Yueju-Ganmaidazao Decoction confers rapid antidepressant-like effects and the involvement of suppression of NMDA/NO/cGMP signaling.
Journal of ethnopharmacology.
2020 Mar; 250(?):112380. doi:
10.1016/j.jep.2019.112380. [PMID: 31707048] - Sergei I Boikov, Dmitry A Sibarov, Sergei M Antonov. Ethanol inhibition of NMDA receptors in calcium-dependent and -independent modes.
Biochemical and biophysical research communications.
2020 02; 522(4):1046-1051. doi:
10.1016/j.bbrc.2019.12.007. [PMID: 31818458] - Josep Dalmau. Letter by Dalmau Regarding Article, 'Serum Anti-NMDA (N-Methyl-D-Aspartate)-Receptor Antibodies and Long-Term Clinical Outcome After Stroke (PROSCIS-B)'.
Stroke.
2020 02; 51(2):e28. doi:
10.1161/strokeaha.119.027885. [PMID: 31928149] - Joanna Gruszczynska-Biegala, Klaudia Strucinska, Filip Maciag, Lukasz Majewski, Maria Sladowska, Jacek Kuznicki. STIM Protein-NMDA2 Receptor Interaction Decreases NMDA-Dependent Calcium Levels in Cortical Neurons.
Cells.
2020 01; 9(1):. doi:
10.3390/cells9010160. [PMID: 31936514] - Junzo Kinoshita, Katsumi Fujita, Kyohei Yasuno, Takami Suzuki, Takuma Iguchi, Takayoshi Nishiya, Kazuhiko Mori. Outer retinal involvement in N-methyl-D-aspartate-induced inner retinal injury in rabbits assessed by optical coherence tomography.
The Journal of toxicological sciences.
2020; 45(5):261-269. doi:
10.2131/jts.45.261. [PMID: 32404558] - Yi-Min Kuo, Pei-Chien Hsu, Chia-Chi Hung, Ya-Yu Hu, Yu-Jie Huang, Yu-Ling Gan, Chun-Hua Lin, Feng-Shiun Shie, Wen-Kuei Chang, Lung-Sen Kao, Mei-Yung Tsou, Yi-Hsuan Lee. Soluble Epoxide Hydrolase Inhibition Attenuates Excitotoxicity Involving 14,15-Epoxyeicosatrienoic Acid-Mediated Astrocytic Survival and Plasticity to Preserve Glutamate Homeostasis.
Molecular neurobiology.
2019 Dec; 56(12):8451-8474. doi:
10.1007/s12035-019-01669-8. [PMID: 31257558] - Yang Zhao, Haiyan Deng, Kun Li, Lijun Wang, Yongkang Wu, Xianwen Dong, Xingyu Wang, Yongjun Chen, Ying Xu. Trans-cinnamaldehyde improves neuroinflammation-mediated NMDA receptor dysfunction and memory deficits through blocking NF-κB pathway in presenilin1/2 conditional double knockout mice.
Brain, behavior, and immunity.
2019 11; 82(?):45-62. doi:
10.1016/j.bbi.2019.07.032. [PMID: 31376499] - Dinesh C Joshi, Chuan-Li Zhang, Lavanya Babujee, Jason D Vevea, Benjamin K August, Zu-Hang Sheng, Edwin R Chapman, Timothy M Gomez, Shing Yan Chiu. Inappropriate Intrusion of an Axonal Mitochondrial Anchor into Dendrites Causes Neurodegeneration.
Cell reports.
2019 10; 29(3):685-696.e5. doi:
10.1016/j.celrep.2019.09.012. [PMID: 31618636] - Angélica María Sabogal-Guáqueta, Fabian Hobbie, Akshaya Keerthi, Asmaa Oun, Arjan Kortholt, Erik Boddeke, Amalia Dolga. Linalool attenuates oxidative stress and mitochondrial dysfunction mediated by glutamate and NMDA toxicity.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Oct; 118(?):109295. doi:
10.1016/j.biopha.2019.109295. [PMID: 31545255] - Venkataramaiah Chintha, Rajendra Wudayagiri. Bioavailability and Neuroprotectivity of 3-(3, 4-dimethoxy phenyl)-1-4 (methoxy phenyl) prop-2-en-1-one against Schizophrenia: an in silico approach.
Journal of receptor and signal transduction research.
2019 Oct; 39(5-6):392-398. doi:
10.1080/10799893.2019.1702689. [PMID: 31829066] - Efthalia Angelopoulou, Christina Piperi. Beneficial Effects of Fingolimod in Alzheimer's Disease: Molecular Mechanisms and Therapeutic Potential.
Neuromolecular medicine.
2019 09; 21(3):227-238. doi:
10.1007/s12017-019-08558-2. [PMID: 31313064] - Cheng-Tsung Liu, Yuahn-Sieh Huang, Hsin-Chien Chen, Kuo-Hsing Ma, Chih-Hung Wang, Chuang-Hsin Chiu, Jui-Hu Shih, Hsiao-Hsien Kang, Chyng-Yann Shiue, I-Hsun Li. Evaluation of brain SERT with 4-[18F]-ADAM/micro-PET and hearing protective effects of dextromethorphan in hearing loss rat model.
Toxicology and applied pharmacology.
2019 09; 378(?):114604. doi:
10.1016/j.taap.2019.114604. [PMID: 31153898] - Hong Feng Liu, ZhengLin Zhao, Jie Zhang, Yi Yan Wu, Yu Jiao, Tong Wu, Sang Chan Kim, Bong Hyo Lee, Yu Fan, Chul Won Lee, Young Woo Kim, Chae Ha Yang, Xiao Dong Zhu, Rong Jie Zhao. Acupuncture reduces nicotine-induced norepinephrine release in the hypothalamus via the solitary NMDA receptor/NOS pathway.
Neuroscience letters.
2019 07; 705(?):33-38. doi:
10.1016/j.neulet.2019.04.036. [PMID: 31004707] - David Soto, Mireia Olivella, Cristina Grau, Judith Armstrong, Clara Alcon, Xavier Gasull, Ana Santos-Gómez, Sílvia Locubiche, Macarena Gómez de Salazar, Roberto García-Díaz, Esther Gratacòs-Batlle, David Ramos-Vicente, Emeline Chu-Van, Benoit Colsch, Víctor Fernández-Dueñas, Francisco Ciruela, Àlex Bayés, Carlos Sindreu, Anna López-Sala, Àngels García-Cazorla, Xavier Altafaj. L-Serine dietary supplementation is associated with clinical improvement of loss-of-function GRIN2B-related pediatric encephalopathy.
Science signaling.
2019 06; 12(586):. doi:
10.1126/scisignal.aaw0936. [PMID: 31213567] - Raffaele Nardone, Viviana Versace, Luca Sebastianelli, Francesco Brigo, Monica Christova, Giuditta Ilaria Scarano, Leopold Saltuari, Eugen Trinka, Larissa Hauer, Johann Sellner. Transcranial magnetic stimulation in subjects with phantom pain and non-painful phantom sensations: A systematic review.
Brain research bulletin.
2019 05; 148(?):1-9. doi:
10.1016/j.brainresbull.2019.03.001. [PMID: 30862485] - Jing-Yuan Wang, Yin-Huan Zhao, Ji-Hui Zhang, Hong-Wei Lei. Anti-N-Methyl-D-Aspartic Acid Receptor 2 (Anti-NR2) Antibody in Neuropsychiatric Lupus Serum Damages the Blood-Brain Barrier and Enters the Brain.
Medical science monitor : international medical journal of experimental and clinical research.
2019 Jan; 25(?):532-539. doi:
10.12659/msm.912389. [PMID: 30657743] - Dai Kakiuchi, Yoshikazu Taketa, Etsuko Ohta, Yasuhiro Fujikawa, Kyoko Nakano-Ito, Shoji Asakura, Satoru Hosokawa. Combination of circulating microRNAs as indicators of specific targets of retinal toxicity in rats.
Toxicology.
2019 01; 411(?):163-171. doi:
10.1016/j.tox.2018.10.008. [PMID: 30336191] - Hiroshi Adachi, Yukiko Ide, Toshiyuki Takahashi, Yukihiro Yoneda, Yasufumi Kageyama. [Cerebral cortical encephalitis with anti-myelin oligodendrocyte glycoprotein (MOG) antibody].
Rinsho shinkeigaku = Clinical neurology.
2018 Dec; 58(12):767-770. doi:
10.5692/clinicalneurol.cn-001224. [PMID: 30487364] - Priyal Barai, Nisith Raval, Sanjeev Acharya, Niyati Acharya. Neuroprotective effects of Bergenia ciliata on NMDA induced injury in SH-SY5Y cells and attenuation of cognitive deficits in scopolamine induced amnesia in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Dec; 108(?):374-390. doi:
10.1016/j.biopha.2018.09.011. [PMID: 30227331] - Dmitry A Sibarov, Ekaterina E Poguzhelskaya, Sergei M Antonov. Downregulation of calcium-dependent NMDA receptor desensitization by sodium-calcium exchangers: a role of membrane cholesterol.
BMC neuroscience.
2018 Nov; 19(1):73. doi:
10.1186/s12868-018-0475-3. [PMID: 30419823] - Lydie Boussicault, Radhia Kacher, Antonin Lamazière, Peter Vanhoutte, Jocelyne Caboche, Sandrine Betuing, Marie-Claude Potier. CYP46A1 protects against NMDA-mediated excitotoxicity in Huntington's disease: Analysis of lipid raft content.
Biochimie.
2018 Oct; 153(?):70-79. doi:
10.1016/j.biochi.2018.07.019. [PMID: 30107216] - María Rodríguez-Muñoz, Yara Onetti, Elsa Cortés-Montero, Javier Garzón, Pilar Sánchez-Blázquez. Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor.
Molecular brain.
2018 09; 11(1):51. doi:
10.1186/s13041-018-0395-2. [PMID: 30223868] - Jung-Hwa Tao-Cheng. Stimulation-induced structural changes at the nucleus, endoplasmic reticulum and mitochondria of hippocampal neurons.
Molecular brain.
2018 07; 11(1):44. doi:
10.1186/s13041-018-0387-2. [PMID: 30049284] - Liur Wang, Guoming Shen, Hao Wang, Mengjie Hu, Yongchuan Yao, Shu Ye. [The effects of electroacupuncture at shu and mu points of stomach on gastric motility, the NMDA of vagus nerve dorsal nucleus and serum NO expression in functional dyspepsia rats].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion.
2018 Mar; 38(3):285-90. doi:
10.13703/j.0255-2930.2018.03.016. [PMID: 29701047] - Alessia Antonini, Silvia Caioli, Luana Saba, Giulia Vindigni, Silvia Biocca, Nadia Canu, Cristina Zona. Membrane cholesterol depletion in cortical neurons highlights altered NMDA receptor functionality in a mouse model of amyotrophic lateral sclerosis.
Biochimica et biophysica acta. Molecular basis of disease.
2018 Feb; 1864(2):509-519. doi:
10.1016/j.bbadis.2017.11.008. [PMID: 29154925] - Benjamin Gronier, Helene M Savignac, Mathieu Di Miceli, Sherif M Idriss, George Tzortzis, Daniel Anthony, Philip W J Burnet. Increased cortical neuronal responses to NMDA and improved attentional set-shifting performance in rats following prebiotic (B-GOS®) ingestion.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2018 01; 28(1):211-224. doi:
10.1016/j.euroneuro.2017.11.001. [PMID: 29174530] - Shigeto Maekawa, Kota Sato, Kosuke Fujita, Reiko Daigaku, Hiroshi Tawarayama, Namie Murayama, Satoru Moritoh, Takeshi Yabana, Yukihiro Shiga, Kazuko Omodaka, Kazuichi Maruyama, Koji M Nishiguchi, Toru Nakazawa. The neuroprotective effect of hesperidin in NMDA-induced retinal injury acts by suppressing oxidative stress and excessive calpain activation.
Scientific reports.
2017 07; 7(1):6885. doi:
10.1038/s41598-017-06969-4. [PMID: 28761134] - Hayder Amin, Thierry Nieus, Davide Lonardoni, Alessandro Maccione, Luca Berdondini. High-resolution bioelectrical imaging of Aβ-induced network dysfunction on CMOS-MEAs for neurotoxicity and rescue studies.
Scientific reports.
2017 05; 7(1):2460. doi:
10.1038/s41598-017-02635-x. [PMID: 28550283] - Robert Schwamborn, Heiko Düssmann, Hans-Georg König, Jochen H M Prehn. Time-lapse imaging of p65 and IκBα translocation kinetics following Ca2+-induced neuronal injury reveals biphasic translocation kinetics in surviving neurons.
Molecular and cellular neurosciences.
2017 04; 80(?):148-158. doi:
10.1016/j.mcn.2017.02.007. [PMID: 28238890] - Fernanda R Marins, Jennifer A Iddings, Marco A P Fontes, Jessica A Filosa. Evidence that remodeling of insular cortex neurovascular unit contributes to hypertension-related sympathoexcitation.
Physiological reports.
2017 Mar; 5(5):. doi:
10.14814/phy2.13156. [PMID: 28270592] - Yuqin Zhang, Lifei Qiao, Wen Xu, Xiaoying Wang, Huang Li, Wei Xu, Kedan Chu, Yu Lin. Paeoniflorin Attenuates Cerebral Ischemia-Induced Injury by Regulating Ca2+/CaMKII/CREB Signaling Pathway.
Molecules (Basel, Switzerland).
2017 Feb; 22(3):. doi:
10.3390/molecules22030359. [PMID: 28264448] - J-D Xia, J Chen, H-J Sun, L-H Zhou, G-Q Zhu, Y Chen, Y-T Dai. Centrally mediated ejaculatory response via sympathetic outflow in rats: role of N-methyl-D-aspartic acid receptors in paraventricular nucleus.
Andrology.
2017 01; 5(1):153-159. doi:
10.1111/andr.12274. [PMID: 27860425] - Azliana Jusnida Ahmad Jafri, Natasha Najwa Nor Arfuzir, Lidawani Lambuk, Igor Iezhitsa, Renu Agarwal, Puneet Agarwal, Norhafiza Razali, Anna Krasilnikova, Maria Kharitonova, Vasily Demidov, Evgeny Serebryansky, Anatoly Skalny, Alexander Spasov, Ahmad Pauzi Md Yusof, Nafeeza Mohd Ismail. Protective effect of magnesium acetyltaurate against NMDA-induced retinal damage involves restoration of minerals and trace elements homeostasis.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS).
2017 Jan; 39(?):147-154. doi:
10.1016/j.jtemb.2016.09.005. [PMID: 27908408] - Ikumi Hayashi, Yuto Aoki, Hiroko Ushikubo, Daiki Asano, Asami Mori, Kenji Sakamoto, Tsutomu Nakahara, Kunio Ishii. Protective effects of PF-4708671 against N-methyl-d-aspartic acid-induced retinal damage in rats.
Fundamental & clinical pharmacology.
2016 Dec; 30(6):529-536. doi:
10.1111/fcp.12216. [PMID: 27371338] - Levente Herman, Ildiko Reka Zsigmond, Laszlo Peter, Janos M Rethelyi. [Review of the psychiatric aspects of anti-NMDA (N-methyl-D-aspartic acid) receptor encephalitis, case report, and our plans for a future study].
Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology.
2016 12; 18(4):199-208. doi:
NULL. [PMID: 28259863] - Jean-Pascal Morin, Sofía Díaz-Cintra, Federico Bermúdez-Rattoni, Ilse Delint-Ramírez. Decreased levels of NMDA but not AMPA receptors in the lipid-raft fraction of 3xTg-AD model of Alzheimer's disease: Relation to Arc/Arg3.1 protein expression.
Neurochemistry international.
2016 11; 100(?):159-163. doi:
10.1016/j.neuint.2016.09.013. [PMID: 27650435] - Harald Hegen, Christian Uprimny, Astrid Grams, Irene Virgolini, Melanie Ramberger, Ronny Beer, Raimund Helbok, Bettina Pfausler, Erich Schmutzhard. Bi-insular cortical involvement in anti-NMDA-receptor encephalitis - a case report.
BMC neurology.
2016 Aug; 16(?):130. doi:
10.1186/s12883-016-0653-9. [PMID: 27502387] - Shafaq Sikandar, Ynette Gustavsson, Marc J Marino, Anthony H Dickenson, Tony L Yaksh, Linda S Sorkin, Roshni Ramachandran. Effects of intraplantar botulinum toxin-B on carrageenan-induced changes in nociception and spinal phosphorylation of GluA1 and Akt.
The European journal of neuroscience.
2016 07; 44(1):1714-22. doi:
10.1111/ejn.13261. [PMID: 27108664] - Amit S Korde, William F Maragos. Direct exposure to N-methyl-d-aspartate alters mitochondrial function.
Neuroscience letters.
2016 06; 623(?):47-51. doi:
10.1016/j.neulet.2016.04.054. [PMID: 27132085] - J Leslie Glick, Philip A McMillan. A multipronged, nutritional-based strategy for managing Alzheimer's disease.
Medical hypotheses.
2016 Jun; 91(?):98-102. doi:
10.1016/j.mehy.2016.04.007. [PMID: 27142155] - Christian Peters, Fernando J Sepúlveda, Eduardo J Fernández-Pérez, Robert W Peoples, Luis G Aguayo. The Level of NMDA Receptor in the Membrane Modulates Amyloid-β Association and Perforation.
Journal of Alzheimer's disease : JAD.
2016 05; 53(1):197-207. doi:
10.3233/jad-160170. [PMID: 27163827] - Chanjuan Zhang, Zhen Wang, Jiayi Zhao, Qin Li, Cuiqin Huang, Lihong Zhu, Daxiang Lu. Neuroprotective Effect of Lutein on NMDA-Induced Retinal Ganglion Cell Injury in Rat Retina.
Cellular and molecular neurobiology.
2016 May; 36(4):531-40. doi:
10.1007/s10571-015-0231-5. [PMID: 26119305] - Helena K Kim, Cameron Isaacs-Trepanier, Nika Elmi, Stanley I Rapoport, Ana C Andreazza. Mitochondrial dysfunction and lipid peroxidation in rat frontal cortex by chronic NMDA administration can be partially prevented by lithium treatment.
Journal of psychiatric research.
2016 May; 76(?):59-65. doi:
10.1016/j.jpsychires.2016.02.001. [PMID: 26894301] - Fernanda Ribeiro Marins, Marcelo Limborço-Filho, Carlos Henrique Xavier, Vinicia C Biancardi, Gisele C Vaz, Javier E Stern, Stephen M Oppenheimer, Marco Antonio Peliky Fontes. Functional topography of cardiovascular regulation along the rostrocaudal axis of the rat posterior insular cortex.
Clinical and experimental pharmacology & physiology.
2016 Apr; 43(4):484-93. doi:
10.1111/1440-1681.12542. [PMID: 26748663] - Jinhua Que, Miao Ye, Yuqin Zhang, Wen Xu, Huang Li, Wei Xu, Kedan Chu. Bryonolic Acid, a Triterpenoid, Protect Against N-methyl-d-Aspartate-Induced Neurotoxicity in PC12 Cells.
Molecules (Basel, Switzerland).
2016 Mar; 21(4):418. doi:
10.3390/molecules21040418. [PMID: 27043504] - Nancy Scardua Binda, Charles Porto Petruceli Carayon, Rafael Mourão Agostini, Ana Cristina do Nascimento Pinheiro, Marta Nascimento Cordeiro, Marco Aurélio Romano Silva, Juliana Figueira Silva, Elizete Maria Rita Pereira, Claudio Antonio da Silva Junior, Célio José de Castro Junior, Andre Luiz Sena Guimarães, Marcus Vinicius Gomez. PhTx3-4, a Spider Toxin Calcium Channel Blocker, Reduces NMDA-Induced Injury of the Retina.
Toxins.
2016 Mar; 8(3):. doi:
10.3390/toxins8030070. [PMID: 26978403] - Xiao-Qian Fang, Haifa Qiao, Bradley R Groveman, Shuang Feng, Melissa Pflueger, Wen-Kuan Xin, Mohammad K Ali, Shuang-Xiu Lin, Jindong Xu, Florian Duclot, Mohamed Kabbaj, Wei Wang, Xin-Sheng Ding, Teresa Santiago-Sim, Xing-Hong Jiang, Michael W Salter, Xian-Min Yu. Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors.
Molecular brain.
2015 Nov; 8(1):75. doi:
10.1186/s13041-015-0167-1. [PMID: 26584860] - Yasukuni Kiyoyuki, Wataru Taniguchi, Masamichi Okubo, Hiroki Yamanaka, Kimiko Kobayashi, Naoko Nishio, Terumasa Nakatsuka, Koichi Noguchi. Leukotriene enhances NMDA-induced inward currents in dorsal horn neurons of the rat spinal cord after peripheral nerve injury.
Molecular pain.
2015 Sep; 11(?):53. doi:
10.1186/s12990-015-0059-5. [PMID: 26353783] - Iandra Holzmann, Luísa Mota da Silva, José Afonso Corrêa da Silva, Viviane Miranda Bispo Steimbach, Márcia Maria de Souza. Antidepressant-like effect of quercetin in bulbectomized mice and involvement of the antioxidant defenses, and the glutamatergic and oxidonitrergic pathways.
Pharmacology, biochemistry, and behavior.
2015 Sep; 136(?):55-63. doi:
10.1016/j.pbb.2015.07.003. [PMID: 26196245] - Zheng-guang Xu, Jun Yang, Zhi-ping Lv, Ting-hua Wang, Xiao-song Li, Jiang-hua Liu, Nan Zhao, Yan-bin Xiyang. [Effect of Herba Lycopodii Alcohol Extracted Granule Combined Methylprednisolone on Expression Levels of BDNF and NMDA and Behavior of Traumatic Spinal Cord Injury Rats].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2015 Aug; 35(8):1004-10. doi:
". [PMID: 26485919] - Xiao-Long Hu, Li-Ping Guo, Qi Song, Qiao Zhang, Ying Chen, Jian Wang, Wei-Hong Meng, Qing-Chun Zhao. Kukoamine B, an amide alkaloid, protects against NMDA-induced neurotoxicity and potential mechanisms in vitro.
Neurochemistry international.
2015 Aug; 87(?):66-76. doi:
10.1016/j.neuint.2015.06.001. [PMID: 26065936] - Michael J Glass, Gang Wang, Christal G Coleman, June Chan, Evgeny Ogorodnik, Tracey A Van Kempen, Teresa A Milner, Scott D Butler, Colin N Young, Robin L Davisson, Costantino Iadecola, Virginia M Pickel. NMDA Receptor Plasticity in the Hypothalamic Paraventricular Nucleus Contributes to the Elevated Blood Pressure Produced by Angiotensin II.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2015 Jul; 35(26):9558-67. doi:
10.1523/jneurosci.2301-14.2015. [PMID: 26134639] - Fanny C F Ip, Wing-Yu Fu, Elaine Y L Cheng, Estella P S Tong, Ka-Chun Lok, Yan Liang, Wen-Cai Ye, Nancy Y Ip. Anemoside A3 Enhances Cognition through the Regulation of Synaptic Function and Neuroprotection.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2015 Jul; 40(8):1877-87. doi:
10.1038/npp.2015.37. [PMID: 25649278] - Katarzyna Młyniec, Magdalena Gaweł, Tadeusz Librowski, Witold Reczyński, Beata Bystrowska, Birgitte Holst. Investigation of the GPR39 zinc receptor following inhibition of monoaminergic neurotransmission and potentialization of glutamatergic neurotransmission.
Brain research bulletin.
2015 Jun; 115(?):23-9. doi:
10.1016/j.brainresbull.2015.04.005. [PMID: 25917396] - Yu Wang, Shanshan Zhao, Zhe Wu, Yu Feng, Chuansheng Zhao, Chaodong Zhang. Oxytocin in the regulation of social behaviours in medial amygdala-lesioned mice via the inhibition of the extracellular signal-regulated kinase signalling pathway.
Clinical and experimental pharmacology & physiology.
2015 May; 42(5):465-74. doi:
10.1111/1440-1681.12378. [PMID: 25707920] - Clarissa S Schitine, Orquidia G Mendez-Flores, Luis E Santos, Isis Ornelas, Karin C Calaza, Karla Pérez-Toledo, Esther López-Bayghen, Arturo Ortega, Patrícia F Gardino, Fernando G de Mello, Ricardo A M Reis. Functional plasticity of GAT-3 in avian Müller cells is regulated by neurons via a glutamatergic input.
Neurochemistry international.
2015 Mar; 82(?):42-51. doi:
10.1016/j.neuint.2015.02.004. [PMID: 25700791] - Romain Chassefeyre, José Martínez-Hernández, Federica Bertaso, Nathalie Bouquier, Béatrice Blot, Marine Laporte, Sandrine Fraboulet, Yohann Couté, Anny Devoy, Adrian M Isaacs, Karin Pernet-Gallay, Rémy Sadoul, Laurent Fagni, Yves Goldberg. Regulation of postsynaptic function by the dementia-related ESCRT-III subunit CHMP2B.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2015 Feb; 35(7):3155-73. doi:
10.1523/jneurosci.0586-14.2015. [PMID: 25698751] - Daiki Asano, Tsutomu Nakahara, Asami Mori, Kenji Sakamoto, Kunio Ishii. Regression of retinal capillaries following N-methyl-D-aspartate-induced neurotoxicity in the neonatal rat retina.
Journal of neuroscience research.
2015 Feb; 93(2):380-90. doi:
10.1002/jnr.23492. [PMID: 25284371] - Mauro Cunha Xavier Pinto, Isabel Vieira de Assis Lima, Flávia Lage Pessoa da Costa, Daniela Valadão Rosa, Vânia Aparecida Mendes-Goulart, Rodrigo Ribeiro Resende, Marco Aurélio Romano-Silva, Antônio Carlos Pinheiro de Oliveira, Marcus Vinícius Gomez, Renato Santiago Gomez. Glycine transporters type 1 inhibitor promotes brain preconditioning against NMDA-induced excitotoxicity.
Neuropharmacology.
2015 Feb; 89(?):274-81. doi:
10.1016/j.neuropharm.2014.10.003. [PMID: 25312280] - Andy J Fischer, Christopher Zelinka, Nima Milani-Nejad. Reactive retinal microglia, neuronal survival, and the formation of retinal folds and detachments.
Glia.
2015 Feb; 63(2):313-27. doi:
10.1002/glia.22752. [PMID: 25231952] - Robin Ortiz, Mark J Niciu, Nada Lukkahati, Leorey N Saligan, Allison C Nugent, David A Luckenbaugh, Rodrigo Machado-Vieira, Carlos A Zarate. Shank3 as a potential biomarker of antidepressant response to ketamine and its neural correlates in bipolar depression.
Journal of affective disorders.
2015 Feb; 172(?):307-11. doi:
10.1016/j.jad.2014.09.015. [PMID: 25451430] - Pavel Montes de Oca Balderas, Penélope Aguilera. A Metabotropic-Like Flux-Independent NMDA Receptor Regulates Ca2+ Exit from Endoplasmic Reticulum and Mitochondrial Membrane Potential in Cultured Astrocytes.
PloS one.
2015; 10(5):e0126314. doi:
10.1371/journal.pone.0126314. [PMID: 25954808] - S A Castner, N V Murthy, K Ridler, H Herdon, B M Roberts, D P Weinzimmer, Y Huang, M Q Zheng, E A Rabiner, R N Gunn, R E Carson, G V Williams, M Laruelle. Relationship between glycine transporter 1 inhibition as measured with positron emission tomography and changes in cognitive performances in nonhuman primates.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2014 Nov; 39(12):2742-9. doi:
10.1038/npp.2014.4. [PMID: 24487737] - Suzanne M Caliph, Fried W Faassen, Christopher J H Porter. The influence of intestinal lymphatic transport on the systemic exposure and brain deposition of a novel highly lipophilic compound with structural similarity to cholesterol.
The Journal of pharmacy and pharmacology.
2014 Oct; 66(10):1377-87. doi:
10.1111/jphp.12268. [PMID: 24821499]
