Matrine (BioDeep_00000003993)

   

PANOMIX_OTCML-2023


代谢物信息卡片


1H,5H,10H-DIPYRIDO(2,1-F:3,2,1-IJ)(1,6)NAPHTHYRIDIN-10-ONE, DODECAHYDRO-, (7AR-(7A.ALPHA.,13A.ALPHA.,13B.BETA.,13C.BETA.))-

化学式: C15H24N2O (248.18885339999997)
中文名称: 苦参碱, 槐定碱, (-)-槐定碱, (+)-槐定啶, 槐定碱, 苦参碱, 母菊碱
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 1.47%

分子结构信息

SMILES: C1CC2C3CCCN4C3C(CCC4)CN2C(=O)C1
InChI: InChI=1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2

描述信息

Matrine is an alkaloid.
Matrine is a natural product found in Daphniphyllum oldhamii, Sophora viciifolia, and other organisms with data available.
Matrine is an alkaloid found in plants from the Sophora genus. It has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor and μ-receptor agonist.
Tetracyclic bis-quinolizidine alkaloids found in the family LEGUMINOSAE, mainly in the genus SOPHORA.
See also: Matrine; salicylic acid (component of).
Annotation level-1
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.230
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.224
Sophoridine is a natural product found in Sophora viciifolia, Leontice leontopetalum, and other organisms with data available.
Tetracyclic bis-quinolizidine alkaloids found in the family LEGUMINOSAE, mainly in the genus SOPHORA.
INTERNAL_ID 2268; CONFIDENCE Reference Standard (Level 1)
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2268
Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI)[1][2][3][4][5].
Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI)[1][2][3][4][5].
Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI)[1][2][3][4][5].
Sophoridine is a quinolizidine alkaloid isolated from Leguminous plant Sophora flavescens. Sophoridine induces apoptosis. Sophoridine has the potential to be a novel, potent and selective antitumor agent candidate for pancreatic cancer with well-tolerated toxicity[1].
Sophoridine is a quinolizidine alkaloid isolated from Leguminous plant Sophora flavescens. Sophoridine induces apoptosis. Sophoridine has the potential to be a novel, potent and selective antitumor agent candidate for pancreatic cancer with well-tolerated toxicity[1].

同义名列表

52 个代谢物同义名

1H,5H,10H-DIPYRIDO(2,1-F:3,2,1-IJ)(1,6)NAPHTHYRIDIN-10-ONE, DODECAHYDRO-, (7AS,13AR,13BR,13CS)-; (7aS,13aR,13bR,13cS)-Dodecahydro-1H,5H,10H-dipyrido[2,1-f:3,2,1-ij][1,6]naphthyridin-10-one; (7aS,13aR,13bS,13cS)dodecahydro-1H,5H,10H-dipyrido[2,1-f:3,2,1-ij][1,6]naphthyridin-10-one; (1R,2R,9S,17S)-7,13-diazatetracyclo[7.7.1.02,7.013,17]heptadecan-6-one; 5-24-02-00301 (Beilstein Handbook Reference); Matridin-15-one;Vegard;alpha-Matrine; Matridin-15-one; Vegard; -Matrine; matrine, (5beta)-isomer; Matrine type Alkaloids; Matrine-type Alkaloids; Matrine ((+)-Matrine); Matrine Alkaloids; MATRINE [WHO-DD]; .alpha.-Matrine; Matridin-15-one; MATRINE [INCI]; alpha-Matrine; Matrene, (+)-; MATRINE [MI]; Matrine,(S); sophoridine; (+)-Matrine; a-Matrine; C15H24N2O; Matrinium; Matrines; Matrine; Vegard; 1H,5H,10H-DIPYRIDO(2,1-F:3,2,1-IJ)(1,6)NAPHTHYRIDIN-10-ONE, DODECAHYDRO-, (7AR-(7A.ALPHA.,13A.ALPHA.,13B.BETA.,13C.BETA.))-; (41S,7aR,13aR,13bR)-dodecahydro-1H,5H,10H-dipyrido[2,1-f:3,2,1-ij][1,6]naphthyridin-10-one; (41S,7aR,13aR,13bR)-Dodecahydro-1H-dipyrido[2,1-f:3,2,1-ij][1,6]naphthyridin-10(41H)-one; (1R,2R,9R,17S)-7,13-diazatetracyclo[7.7.1.02,7.013,17]heptadecan-6-one; ZSBXGIUJOOQZMP-BHPKHCPMSA-N; Matridin-15-one, (6.beta.)-; Matridin-15-one, (5-beta)-; Dihydro-5-episophocarpine; 5-Epidihydrosophocarpine; (5-beta)-Matridin-15-one; Tetrahydroisosophoramine; SOPHORIDINE [WHO-DD]; Sophoridine,(S); 6.beta.-Matrine; UNII-W5S1M800J7; (-)-SOPHORIDINE; l-Sophoridine; 6-Allomatrine; d-Sophoridine; W5S1M800J7; Sophoridin; 1ST40361; (+)-Sophoridine; α-Matrine



数据库引用编号

61 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

91 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Lin Zhu, Yongle Yu, Youfu Ma, Yenong Shi, Jamal Alzobair Hammad Kowah, Lisheng Wang, Mingqing Yuan, Xu Liu. QSAR prediction, synthesis, anticancer evaluation, and mechanistic investigations of novel sophoridine derivatives as topoisomerase I inhibitors. Fitoterapia. 2024 Jun; 175(?):105921. doi: 10.1016/j.fitote.2024.105921. [PMID: 38561052]
  • Yan Zhi, Xinping Zhao, Zhenyi Liu, Guoyu Shen, Taiming Zhang, Tao Zhang, Ge Hu. Oxymatrine Modulation of TLR3 Signaling: A Dual-Action Mechanism for H9N2 Avian Influenza Virus Defense and Immune Regulation. Molecules (Basel, Switzerland). 2024 Apr; 29(9):. doi: 10.3390/molecules29091945. [PMID: 38731436]
  • Sitong Lai, Bing Wang, Kunhui Sun, Fan Li, Qian Liu, Xie-An Yu, Lihe Jiang, Lisheng Wang. Self-Assembled Matrine-PROTAC Encapsulating Zinc(II) Phthalocyanine with GSH-Depletion-Enhanced ROS Generation for Cancer Therapy. Molecules (Basel, Switzerland). 2024 Apr; 29(8):. doi: 10.3390/molecules29081845. [PMID: 38675664]
  • Chu Erfu, Liu Li, Qu Weiting, Chi Tao, Ma Liwei, Yang Hemin, Lu Junkun. Matrine attenuating cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity through improved mitochondrial membrane potential and activation of mitochondrial respiratory chain Complex I pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Apr; 173(?):116464. doi: 10.1016/j.biopha.2024.116464. [PMID: 38503242]
  • Ruiyang Jiang, Zihan Fang, Yueyang Lai, Liu Li, Jiani Tan, Chengtao Yu, Minmin Fan, Lihuiping Tao, Weixing Shen, Changliang Xu, Dongdong Sun, Haibo Cheng. Sophocarpine alleviates intestinal fibrosis via inhibition of inflammation and fibroblast into myofibroblast transition by targeting the Sirt1/p65 signaling axis. European journal of pharmacology. 2024 Mar; 967(?):176318. doi: 10.1016/j.ejphar.2024.176318. [PMID: 38309678]
  • Jinying Lu, Jiang Bian, Yutong Wang, Yan Zhao, Xinmin Zhao, Gao Wang, Jing Yang. Oxymatrine protects articular chondrocytes from IL-1β-induced damage through autophagy activation via AKT/mTOR signaling pathway inhibition. Journal of orthopaedic surgery and research. 2024 Mar; 19(1):178. doi: 10.1186/s13018-024-04667-2. [PMID: 38468339]
  • Zhenting Ding, Ke Wei, Yiwu Zhang, Xueli Ma, Liu Yang, Weiguang Zhang, Huixiang Liu, Chunyan Jia, Weixing Shen, Shencheng Ma, Li Xu, Chenggang Zhou, Yanxue Liu, Shangkun Gao, Yingchao Ji. 'One-Pot' Method Preparation of Dendritic Mesoporous Silica-Loaded Matrine Nanopesticide for Noninvasive Administration Control of Monochamus alternatus: The Vector Insect of Bursapherenchus xylophophilus. ACS biomaterials science & engineering. 2024 Mar; 10(3):1507-1516. doi: 10.1021/acsbiomaterials.3c01270. [PMID: 38372256]
  • Ding Luo, Jia-Wen Zou, Jing-Hao Wang, He Tian, Hua-Yan Xie, Tian-Xi Zhu, Hui-Hui Zhu, Lu-Ming Deng, Chun-Lin Fan, Hao Wang, Guo-Cai Wang, Yu-Bo Zhang. Undescribed matrine-type alkaloids from Sophora alopecuroides with anti-inflammatory activity. Phytochemistry. 2024 Feb; 218(?):113954. doi: 10.1016/j.phytochem.2023.113954. [PMID: 38104747]
  • Jingchun Sun, Xiaoting Wang, Yulin He, Xuekai Tian, Tiantian Yuan, Gongshe Yang, Taiyong Yu. Sophoridine Counteracts Obesity via Src-Mediated Inhibition of VEGFR Expression and PI3K/AKT Phosphorylation. International journal of molecular sciences. 2024 Jan; 25(2):. doi: 10.3390/ijms25021206. [PMID: 38279206]
  • Jingbo Liu, Bingyan Guo, Siying Zhong, Yabing Shi, Zhengping Li, Zhenwu Yu, Zesheng Hao, Li Zhang, Fengyun Li, Yuanhong Wang, Yuxin Li. Novel Evodiamine-Based Sulfonamide Derivatives as Potent Insecticide Candidates Targeting Insect Ryanodine Receptors. Journal of agricultural and food chemistry. 2024 Jan; 72(2):1292-1301. doi: 10.1021/acs.jafc.3c05680. [PMID: 38178001]
  • Ashmita Das, Onkar Kashyap, Devi P Pandey, Surendra H Bodakhe. Oxymatrine impedes the progression of endotoxin-induced glaucoma via redox system modulations. Journal of biochemical and molecular toxicology. 2024 Jan; 38(1):e23631. doi: 10.1002/jbt.23631. [PMID: 38229309]
  • Jiaqi Jin, Zhaofeng Fan, Yonglin Long, Yinping Li, Qian He, Yiming Yang, Weijian Zhong, Disheng Lin, Dawei Lian, Xiao Wang, Jing Xiao, Yang Chen. Matrine induces ferroptosis in cervical cancer through activation of piezo1 channel. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 122(?):155165. doi: 10.1016/j.phymed.2023.155165. [PMID: 37922791]
  • Xiaochuan Tan, Yumei Hao, Nai Ma, Yige Yang, Wenzhen Jin, Ya Meng, Chuchu Zhou, Wensheng Zheng, Yujia Zhang. M6P-modified solid lipid nanoparticles loaded with matrine for the treatment of fibrotic liver. Drug delivery. 2023 Dec; 30(1):2219432. doi: 10.1080/10717544.2023.2219432. [PMID: 37300371]
  • Benjamin Christian Fischer, Yemurai Musengi, Jeannette König, Benjamin Sachse, Stefanie Hessel-Pras, Bernd Schäfer, Carsten Kneuer, Kristin Herrmann. Matrine and Oxymatrine: Evaluating the gene mutation potential using in silico tools and the bacterial reverse mutation assay (Ames test). Mutagenesis. 2023 Oct; ?(?):. doi: 10.1093/mutage/gead032. [PMID: 37877816]
  • Yifei Gao, Chao Wu, Jiaqi Huang, Zhihong Huang, Zhengsen Jin, Siyu Guo, Xiaoyu Tao, Shan Lu, Jingyuan Zhang, Fanqin Zhang, Yiyan Zhai, Rui Shi, Peizhi Ye, Jiarui Wu. A new strategy to identify ADAM12 and PDGFRB as a novel prognostic biomarker for matrine regulates gastric cancer via high throughput chip mining and computational verification. Computers in biology and medicine. 2023 Oct; 166(?):107562. doi: 10.1016/j.compbiomed.2023.107562. [PMID: 37847945]
  • Xi Wang, Wenjing Zhu, Miao Xing, Haiyan Zhu, Enqing Chen, Jie Zhou. Matrine disrupts Nrf2/GPX4 antioxidant system and promotes hepatocyte ferroptosis. Chemico-biological interactions. 2023 Sep; ?(?):110713. doi: 10.1016/j.cbi.2023.110713. [PMID: 37716422]
  • Q Jin, Z Li, Q Xu, Q Liu. Matrine From Sophora Flavescens Attenuates on Collagen-Induced Osteoarthritis by Modulating the Activity of miR-29B-3P/PGRN Axis. Physiological research. 2023 Aug; 72(4):475-483. doi: . [PMID: 37795890]
  • Xingan Cheng, Fangyun Dong, Junjie Li, Qiwen Zou, Xin Liu, Huiqing He, Hanhui Zhang, Xiaojing Lv, Yuehua Wu, Xuhong Jiang, Xiangjing Qin. Synthesis, and biological evaluation of pyrazole matrine derivatives as an insecticide against Spodoptera frugiperda. Pesticide biochemistry and physiology. 2023 Aug; 194(?):105489. doi: 10.1016/j.pestbp.2023.105489. [PMID: 37532351]
  • Shijie Wei, Yubao Zhang, Xiaoran Ma, Yan Yao, Qinqin Zhou, Wenfeng Zhang, Chao Zhou, Jing Zhuang. MAT as a promising therapeutic strategy against triple-negative breast cancer via inhibiting PI3K/AKT pathway. Scientific reports. 2023 07; 13(1):12351. doi: 10.1038/s41598-023-39655-9. [PMID: 37524857]
  • Jinlei Li, Shijie Wei, Davies Marabada, Zhizhong Wang, Qing Huang. Research Progress of Natural Matrine Compounds and Synthetic Matrine Derivatives. Molecules (Basel, Switzerland). 2023 Jul; 28(15):. doi: 10.3390/molecules28155780. [PMID: 37570750]
  • Zhigang Cao, Xiaoya Ling, Panpan Sun, Xiaozhong Zheng, Hua Zhang, Jia Zhong, Wei Yin, Kuohai Fan, Yaogui Sun, Hongquan Li, Na Sun. Matrine Targets Intestinal Lactobacillus acidophilus to Inhibit Porcine Circovirus Type 2 Infection in Mice. International journal of molecular sciences. 2023 Jul; 24(15):. doi: 10.3390/ijms241511878. [PMID: 37569261]
  • Zheng Sun, Bin Zhang, Wenkui Li, Yiwan Zhou, Jing Zhang, Jun Wang, Zhiqing Ma. Matrine can be absorbed and transmitted bidirectionally to defend against aphids (Hemiptera: Aphididae) on wheat and pepper. Pest management science. 2023 Jun; 79(6):2098-2106. doi: 10.1002/ps.7376. [PMID: 36693803]
  • Ding Luo, Xiaoyong Dai, He Tian, Chunlin Fan, Huayan Xie, Nenghua Chen, Jinghao Wang, Laiqiang Huang, Hao Wang, Guocai Wang, Yubo Zhang. Sophflarine A, a novel matrine-derived alkaloid from Sophora flavescens with therapeutic potential for non-small cell lung cancer through ROS-mediated pyroptosis and autophagy. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 May; 116(?):154909. doi: 10.1016/j.phymed.2023.154909. [PMID: 37269775]
  • Swesha Chhabra, Sidharth Mehan. Matrine exerts its neuroprotective effects by modulating multiple neuronal pathways. Metabolic brain disease. 2023 Apr; ?(?):. doi: 10.1007/s11011-023-01214-6. [PMID: 37103719]
  • Jiamei Liu, Yangtian Liu, Bing Liu, Changchun Dai, Peiling Wang, Yanhui Lu. Life-table parameters, functional response, flight ability, and cross-generational effects of matrine demonstrate its safety to Hippodamia variegata (Coleoptera: Coccinellidae). Journal of economic entomology. 2023 Apr; ?(?):. doi: 10.1093/jee/toad068. [PMID: 37075482]
  • Song Ang, Jinfeng Liang, Wende Zheng, Zhen Zhang, Jinxuan Li, Zhenping Yan, Wing-Leung Wong, Kun Zhang, Min Chen, Panpan Wu. Novel Matrine Derivatives as Potential Larvicidal Agents against Aedes albopictus: Synthesis, Biological Evaluation, and Mechanistic Analysis. Molecules (Basel, Switzerland). 2023 Mar; 28(7):. doi: 10.3390/molecules28073035. [PMID: 37049799]
  • Peng Zhang, Ji Zhang, Qiao An, Juan Wang, Ping Yi, Chun-Mao Yuan, Zhong-Kai Zhang, Li-Hua Zhao, Zhan-Xing Hu, Xiao-Jiang Hao. Matrine-Type Alkaloids with Anti-Tomato Spotted Wilt Virus Activity from the Root of Sophora tonkinensis Gagnep. Journal of agricultural and food chemistry. 2023 Mar; 71(10):4394-4407. doi: 10.1021/acs.jafc.2c09003. [PMID: 36854107]
  • Pan Huang, Fan Hu, Zhi-Bo Yang, Yi Pan, Rong Zhou, Yi-Ning Yan, Hai-Zhen Wang, Chang Wang. Matrine regulates Th1/Th2 inflammatory responses by inhibiting the Hsp90/NF-κB signaling axis to alleviate atopic dermatitis. The Kaohsiung journal of medical sciences. 2023 Feb; ?(?):. doi: 10.1002/kjm2.12655. [PMID: 36757049]
  • Yang Li, Bi Wu, Xin Hao, Jian Diao, Jingxin Cao, Ruina Tan, Wei Ma, Ling Ma. Functional analysis of 3 genes in xenobiotic detoxification pathway of Bursaphelenchus xylophilus against matrine. Pesticide biochemistry and physiology. 2023 Feb; 190(?):105334. doi: 10.1016/j.pestbp.2022.105334. [PMID: 36740342]
  • Tao Song, Yuanyuan Hao, Mingye Wang, Tongtong Li, Chi Zhao, Jiajia Li, Yunlong Hou. Sophoridine manifests as a leading compound for anti-arrhythmia with multiple ion-channel blocking effects. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Jan; 112(?):154688. doi: 10.1016/j.phymed.2023.154688. [PMID: 36738478]
  • Lingyu Li, Jingrong Li, Liyan Ma, Hai Shang, Zhongmei Zou. SAR-guided development of indole-matrine hybrids as potential anticancer agents via mitochondrial stress/cytochrome c/caspase 3 signaling pathway. Bioorganic chemistry. 2023 Jan; 134(?):106341. doi: 10.1016/j.bioorg.2023.106341. [PMID: 36842321]
  • Qiu Du, Yingda Lin, Changping Ding, Ling Wu, Yuan Xu, Qingling Feng. Pharmacological Activity of Matrine in Inhibiting Colon Cancer Cells VM Formation, Proliferation, and Invasion by Downregulating Claudin-9 Mediated EMT Process and MAPK Signaling Pathway. Drug design, development and therapy. 2023; 17(?):2787-2804. doi: 10.2147/dddt.s417077. [PMID: 37719361]
  • Si-Wei Rao, Yuan-Yuan Duan, Dong-Sheng Zhao, Cheng-Jun Liu, Shao-Hua Xu, Dong Liang, Feng-Xiang Zhang, Wei Shi. Integrative Analysis of Transcriptomic and Metabolomic Data for Identification of Pathways Related to Matrine-Induced Hepatotoxicity. Chemical research in toxicology. 2022 12; 35(12):2271-2284. doi: 10.1021/acs.chemrestox.2c00264. [PMID: 36440846]
  • Yun Cheng, Chen Yu, Weibing Li, Yongming He, Yuhua Bao. Matrine Inhibits Proliferation, Invasion, and Migration and Induces Apoptosis of Colorectal Cancer Cells Via miR-10b/PTEN Pathway. Cancer biotherapy & radiopharmaceuticals. 2022 Dec; 37(10):871-881. doi: 10.1089/cbr.2020.3800. [PMID: 32907349]
  • Mingrong Liang, Senquan Zhang, Xiaobin Zheng, Jiefu Deng, Jiaqi Yang, Yuling Liang, Zhiqiang Li, Xinlu Yue, Yongyue Lu, Yijuan Xu, Lei Wang. Efficacy of Matrine, Rotenone, and Pyrethrin Against Red Imported Fire Ant Solenopsis invicta (Hymenoptera: Formicidae) and Their Impact on Aquatic Organisms. Environmental entomology. 2022 10; 51(5):948-957. doi: 10.1093/ee/nvac072. [PMID: 36130186]
  • Jeff K Kerkovius, Andrea Stegner, Aneta Turlik, Pik Hoi Lam, Kendall N Houk, Sarah E Reisman. A Pyridine Dearomatization Approach to the Matrine-Type Lupin Alkaloids. Journal of the American Chemical Society. 2022 09; 144(35):15938-15943. doi: 10.1021/jacs.2c06584. [PMID: 36006400]
  • Nanjing Liu, Chunmei Yang, Li Yang, Ting Li, Maoyuan Gong, Haobiao Wang, Jun Zhang, Hui Zhao, Lin Zou, Xiaoyan He. Matrine induces autophagy in human neuroblastoma cells via blocking the AKT-mTOR pathway. Medical oncology (Northwood, London, England). 2022 Aug; 39(11):167. doi: 10.1007/s12032-022-01762-4. [PMID: 35972593]
  • Xingan Cheng, Huiqing He, Fangyun Dong, Chunbao Charles Xu, Hanhui Zhang, Zhanmei Liu, Xiaojing Lv, Yuehua Wu, Xuhong Jiang, Xiangjing Qin. Synthesis of Halopyrazole Matrine Derivatives and Their Insecticidal and Fungicidal Activities. Molecules (Basel, Switzerland). 2022 Aug; 27(15):. doi: 10.3390/molecules27154974. [PMID: 35956924]
  • Yi Zhou, Jiyingzi Wu, Sukun Lin, Junlang He, Yangyang Deng, Jingchao He, Dongmei Cheng. The synergistic effects of rosehip oil and matrine against Icerya aegyptiaca (Douglas) (Hemiptera: Coccoidea) and the underlying mechanisms. Pest management science. 2022 Aug; 78(8):3424-3432. doi: 10.1002/ps.6983. [PMID: 35545955]
  • Lu Yuan, Jingchao Yang, Ying Li, Longhui Yuan, Fei Liu, Yujia Yuan, Xiaochi Tang. Matrine alleviates cisplatin-induced acute kidney injury by inhibiting mitochondrial dysfunction and inflammation via SIRT3/OPA1 pathway. Journal of cellular and molecular medicine. 2022 07; 26(13):3702-3715. doi: 10.1111/jcmm.17398. [PMID: 35650472]
  • Chao Zhang, Lan Wang, Yixiang Xu, Yunyuan Huang, Junyang Huang, Jin Zhu, Wei Wang, Wangsheng Li, Annan Sun, Xiaokang Li, Haiyan Zhang, Jian Li. Discovery of novel dual RAGE/SERT inhibitors for the potential treatment of the comorbidity of Alzheimer's disease and depression. European journal of medicinal chemistry. 2022 Jun; 236(?):114347. doi: 10.1016/j.ejmech.2022.114347. [PMID: 35430560]
  • Mona Kordestani, Kamran Mahdian, Valiollah Baniameri, Aziz Sheikhi Garjan. Proteus, Matrine, and Pyridalyl Toxicity and Their Sublethal Effects on Orius laevigatus (Hemiptera: Anthocoridae). Journal of economic entomology. 2022 04; 115(2):573-581. doi: 10.1093/jee/toab267. [PMID: 35078239]
  • Pan-Ling Xu, Chien-Shan Cheng, Ju-Ying Jiao, Hao Chen, Zhen Chen, Ping Li. Matrine injection inhibits pancreatic cancer growth via modulating carbonic anhydrases- a network pharmacology-based study with in vitro validation. Journal of ethnopharmacology. 2022 Apr; 287(?):114691. doi: 10.1016/j.jep.2021.114691. [PMID: 34597654]
  • Hongtao Ren, Yali Wang, Ya Guo, Mincong Wang, Xiulong Ma, Wen Li, Yuyan Guo, Yiming Li. Matrine impedes colorectal cancer proliferation and migration by downregulating endoplasmic reticulum lipid raft associated protein 1 expression. Bioengineered. 2022 04; 13(4):9780-9791. doi: 10.1080/21655979.2022.2060777. [PMID: 35412433]
  • Fengyuan Chen, Yunxia Pan, Jing Xu, Bin Liu, Hang Song. Research progress of matrine's anticancer activity and its molecular mechanism. Journal of ethnopharmacology. 2022 Mar; 286(?):114914. doi: 10.1016/j.jep.2021.114914. [PMID: 34919987]
  • Chan Li, Yao-Hao Xu, Yu-Tao Hu, Xiu Zhou, Zhi-Shu Huang, Ji-Ming Ye, Yong Rao. Matrine counteracts obesity in mice via inducing adipose thermogenesis by activating HSF1/PGC-1α axis. Pharmacological research. 2022 03; 177(?):106136. doi: 10.1016/j.phrs.2022.106136. [PMID: 35202821]
  • Ruyi Zhang, Wenli Liao, Ke Wu, Liangliang Hua, Mengyu Wu, Cairong Li, Fei Cai. Matrine alleviates spatial learning and memory impairment in diabetic mice by inhibiting endoplasmic reticulum stress and through modulation of PK2/PKRs pathway. Neurochemistry international. 2022 03; 154(?):105289. doi: 10.1016/j.neuint.2022.105289. [PMID: 35074478]
  • Pengqi Guo, Fanru Zhong, Yongze Zhao, Xinya Xu, Weiming Xue, Yichen Wang, Xiaoping Song, Weili Tang, Daidi Fan. Thermosensitive molecularly imprinted polymer coupled with HPLC for selective enrichment and determination of matrine in traditional Chinese medicine. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2022 Feb; 1191(?):123130. doi: 10.1016/j.jchromb.2022.123130. [PMID: 35066245]
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