Matrine (BioDeep_00000003993)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


1H,5H,10H-DIPYRIDO(2,1-F:3,2,1-IJ)(1,6)NAPHTHYRIDIN-10-ONE, DODECAHYDRO-, (7AR-(7A.ALPHA.,13A.ALPHA.,13B.BETA.,13C.BETA.))-

化学式: C15H24N2O (248.1889)
中文名称: (-)-槐定碱, (+)-槐定啶, 槐定碱, 苦参碱, 母菊碱
谱图信息: 最多检出来源 Viridiplantae(plant) 27.19%

分子结构信息

SMILES: C1CC2C3CCCN4C3C(CCC4)CN2C(=O)C1
InChI: InChI=1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2

描述信息

Matrine is an alkaloid.
Matrine is a natural product found in Daphniphyllum oldhamii, Sophora viciifolia, and other organisms with data available.
Matrine is an alkaloid found in plants from the Sophora genus. It has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor and μ-receptor agonist.
Tetracyclic bis-quinolizidine alkaloids found in the family LEGUMINOSAE, mainly in the genus SOPHORA.
See also: Matrine; salicylic acid (component of).
Annotation level-1
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.230
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.224
Sophoridine is a natural product found in Sophora viciifolia, Leontice leontopetalum, and other organisms with data available.
Tetracyclic bis-quinolizidine alkaloids found in the family LEGUMINOSAE, mainly in the genus SOPHORA.
INTERNAL_ID 2268; CONFIDENCE Reference Standard (Level 1)
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2268
Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI)[1][2][3][4][5].
Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI)[1][2][3][4][5].
Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus that can act as a kappa opioid receptor and u-receptor agonist. Matrine has a variety of pharmacological effects, including anti-cancer, anti-oxidative stress, anti-inflammation and anti-apoptosis effects. Matrine is potential in the research of disease like human non-small cell lung cancer, hepatoma, papillary thyroid cancer and acute kidney injury (AKI)[1][2][3][4][5].
Sophoridine is a quinolizidine alkaloid isolated from Leguminous plant Sophora flavescens. Sophoridine induces apoptosis. Sophoridine has the potential to be a novel, potent and selective antitumor agent candidate for pancreatic cancer with well-tolerated toxicity[1].
Sophoridine is a quinolizidine alkaloid isolated from Leguminous plant Sophora flavescens. Sophoridine induces apoptosis. Sophoridine has the potential to be a novel, potent and selective antitumor agent candidate for pancreatic cancer with well-tolerated toxicity[1].

同义名列表

54 个代谢物同义名

1H,5H,10H-DIPYRIDO(2,1-F:3,2,1-IJ)(1,6)NAPHTHYRIDIN-10-ONE, DODECAHYDRO-, (7AS,13AR,13BR,13CS)-; (7aS,13aR,13bR,13cS)-Dodecahydro-1H,5H,10H-dipyrido[2,1-f:3,2,1-ij][1,6]naphthyridin-10-one; (7aS,13aR,13bS,13cS)dodecahydro-1H,5H,10H-dipyrido[2,1-f:3,2,1-ij][1,6]naphthyridin-10-one; (1R,2R,9S,17S)-7,13-diazatetracyclo[7.7.1.02,7.013,17]heptadecan-6-one; 5-24-02-00301 (Beilstein Handbook Reference); Matridin-15-one;Vegard;alpha-Matrine; Matridin-15-one; Vegard; -Matrine; matrine, (5beta)-isomer; Matrine type Alkaloids; Matrine-type Alkaloids; Matrine ((+)-Matrine); Matrine Alkaloids; MATRINE [WHO-DD]; .alpha.-Matrine; Matridin-15-one; MATRINE [INCI]; alpha-Matrine; Matrene, (+)-; MATRINE [MI]; Matrine,(S); sophoridine; (+)-Matrine; a-Matrine; C15H24N2O; Matrinium; Matrines; Matrine; Vegard; 1H,5H,10H-DIPYRIDO(2,1-F:3,2,1-IJ)(1,6)NAPHTHYRIDIN-10-ONE, DODECAHYDRO-, (7AR-(7A.ALPHA.,13A.ALPHA.,13B.BETA.,13C.BETA.))-; (41S,7aR,13aR,13bR)-dodecahydro-1H,5H,10H-dipyrido[2,1-f:3,2,1-ij][1,6]naphthyridin-10-one; (41S,7aR,13aR,13bR)-Dodecahydro-1H-dipyrido[2,1-f:3,2,1-ij][1,6]naphthyridin-10(41H)-one; (1R,2R,9R,17S)-7,13-diazatetracyclo[7.7.1.02,7.013,17]heptadecan-6-one; ZSBXGIUJOOQZMP-BHPKHCPMSA-N; Matridin-15-one, (6.beta.)-; Matridin-15-one, (5-beta)-; Dihydro-5-episophocarpine; 5-Epidihydrosophocarpine; (5-beta)-Matridin-15-one; Tetrahydroisosophoramine; SOPHORIDINE [WHO-DD]; Sophoridine,(S); 6.beta.-Matrine; UNII-W5S1M800J7; (-)-SOPHORIDINE; l-Sophoridine; 6-Allomatrine; d-Sophoridine; W5S1M800J7; Sophoridin; 1ST40361; (+)-Sophoridine; Sophoridine; α-Matrine; Matrine



数据库引用编号

66 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

168 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 AKT1, CAT, CTNNB1, EGFR, JAK2, MTOR, MYC, NOS2, PIK3CA, PTGS2, STAT3, TP53
Peripheral membrane protein 4 ACHE, JAK2, MTOR, PTGS2
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 3 EGFR, MTOR, PTGS2
Nucleus 11 ACHE, AKT1, CTNNB1, EGFR, JAK2, MPO, MTOR, MYC, NOS2, STAT3, TP53
cytosol 10 AKT1, CAT, CTNNB1, GPT, JAK2, MTOR, NOS2, PIK3CA, STAT3, TP53
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
centrosome 2 CTNNB1, TP53
nucleoplasm 9 AKT1, CTNNB1, JAK2, MPO, MTOR, MYC, NOS2, STAT3, TP53
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 5 ACHE, AKT1, CD8A, CTNNB1, EGFR
Cytoplasmic side 1 MTOR
lamellipodium 3 AKT1, CTNNB1, PIK3CA
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Golgi apparatus membrane 1 MTOR
Synapse 2 ACHE, CTNNB1
cell cortex 2 AKT1, CTNNB1
cell junction 2 CTNNB1, EGFR
cell surface 2 ACHE, EGFR
glutamatergic synapse 4 AKT1, CTNNB1, EGFR, JAK2
Golgi apparatus 1 ACHE
Golgi membrane 2 EGFR, MTOR
lysosomal membrane 1 MTOR
neuromuscular junction 1 ACHE
postsynapse 2 AKT1, JAK2
presynaptic membrane 1 CTNNB1
Cytoplasm, cytosol 1 NOS2
Lysosome 2 MPO, MTOR
endosome 1 EGFR
plasma membrane 10 ACHE, AKT1, CD8A, CTNNB1, EGFR, IFNLR1, JAK2, NOS2, PIK3CA, STAT3
Membrane 10 ACHE, AKT1, CAT, CTNNB1, EGFR, IFNLR1, JAK2, MTOR, MYC, TP53
apical plasma membrane 1 EGFR
basolateral plasma membrane 2 CTNNB1, EGFR
caveola 2 JAK2, PTGS2
extracellular exosome 4 CAT, CTNNB1, GPT, MPO
Lysosome membrane 1 MTOR
endoplasmic reticulum 2 PTGS2, TP53
extracellular space 6 ACHE, CCL2, EGFR, IL17A, IL4, MPO
perinuclear region of cytoplasm 5 ACHE, CTNNB1, EGFR, NOS2, PIK3CA
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
intercalated disc 1 PIK3CA
mitochondrion 2 CAT, TP53
protein-containing complex 7 AKT1, CAT, CTNNB1, EGFR, MYC, PTGS2, TP53
intracellular membrane-bounded organelle 2 CAT, MPO
Microsome membrane 2 MTOR, PTGS2
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 3 CD8A, EGFR, IFNLR1
Secreted 4 ACHE, CCL2, IL17A, IL4
extracellular region 7 ACHE, CAT, CCL2, CD8A, IL17A, IL4, MPO
cytoplasmic side of plasma membrane 1 JAK2
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 1 MTOR
[Isoform 2]: Secreted 1 CD8A
Mitochondrion matrix 1 TP53
mitochondrial matrix 2 CAT, TP53
Extracellular side 1 ACHE
transcription regulator complex 3 CTNNB1, STAT3, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
nuclear membrane 1 EGFR
external side of plasma membrane 2 CD8A, IL17A
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
microtubule cytoskeleton 1 AKT1
nucleolus 2 MYC, TP53
Wnt signalosome 1 CTNNB1
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
apical part of cell 1 CTNNB1
cell-cell junction 2 AKT1, CTNNB1
vesicle 1 AKT1
postsynaptic membrane 1 CTNNB1
Cytoplasm, perinuclear region 1 NOS2
Membrane raft 2 EGFR, JAK2
Cytoplasm, cytoskeleton 2 CTNNB1, TP53
focal adhesion 4 CAT, CTNNB1, EGFR, JAK2
spindle 1 AKT1
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
Peroxisome 2 CAT, NOS2
basement membrane 1 ACHE
intracellular vesicle 1 EGFR
Peroxisome matrix 1 CAT
peroxisomal matrix 2 CAT, NOS2
peroxisomal membrane 1 CAT
Nucleus, PML body 2 MTOR, TP53
PML body 2 MTOR, TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 1 MPO
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 2 CD8A, EGFR
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 3 MYC, STAT3, TP53
cell periphery 1 CTNNB1
cytoskeleton 1 JAK2
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
Nucleus, nucleolus 1 MYC
spindle pole 1 CTNNB1
postsynaptic density, intracellular component 1 CTNNB1
Lipid-anchor, GPI-anchor 1 ACHE
microvillus membrane 1 CTNNB1
site of double-strand break 1 TP53
nuclear envelope 2 MTOR, MYC
Endomembrane system 3 CTNNB1, JAK2, MTOR
endosome lumen 1 JAK2
Nucleus, nucleoplasm 1 MYC
euchromatin 2 CTNNB1, JAK2
side of membrane 1 ACHE
germ cell nucleus 1 TP53
replication fork 1 TP53
basal plasma membrane 1 EGFR
azurophil granule 1 MPO
synaptic membrane 1 EGFR
plasma membrane raft 1 CD8A
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
endoplasmic reticulum lumen 1 PTGS2
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
RNA polymerase II transcription repressor complex 1 MYC
beta-catenin-TCF complex 1 CTNNB1
azurophil granule lumen 1 MPO
presynaptic active zone cytoplasmic component 1 CTNNB1
clathrin-coated endocytic vesicle membrane 1 EGFR
phagocytic vesicle lumen 1 MPO
[Isoform 1]: Nucleus 1 TP53
extrinsic component of cytoplasmic side of plasma membrane 1 JAK2
synaptic cleft 1 ACHE
protein-DNA complex 1 CTNNB1
[Isoform 1]: Cell membrane 1 CD8A
Rough endoplasmic reticulum 1 MYC
Cytoplasmic vesicle, phagosome 1 MTOR
extrinsic component of plasma membrane 1 JAK2
granulocyte macrophage colony-stimulating factor receptor complex 1 JAK2
interleukin-12 receptor complex 1 JAK2
interleukin-23 receptor complex 1 JAK2
catenin complex 1 CTNNB1
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
Myc-Max complex 1 MYC
T cell receptor complex 1 CD8A
cortical cytoskeleton 1 NOS2
catalase complex 1 CAT
beta-catenin-TCF7L2 complex 1 CTNNB1
[Isoform H]: Cell membrane 1 ACHE
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
interleukin-28 receptor complex 1 IFNLR1
nucleoplasmic reticulum 1 MYC


文献列表

  • Lin Zhu, Yongle Yu, Youfu Ma, Yenong Shi, Jamal Alzobair Hammad Kowah, Lisheng Wang, Mingqing Yuan, Xu Liu. QSAR prediction, synthesis, anticancer evaluation, and mechanistic investigations of novel sophoridine derivatives as topoisomerase I inhibitors. Fitoterapia. 2024 Jun; 175(?):105921. doi: 10.1016/j.fitote.2024.105921. [PMID: 38561052]
  • Yan Zhi, Xinping Zhao, Zhenyi Liu, Guoyu Shen, Taiming Zhang, Tao Zhang, Ge Hu. Oxymatrine Modulation of TLR3 Signaling: A Dual-Action Mechanism for H9N2 Avian Influenza Virus Defense and Immune Regulation. Molecules (Basel, Switzerland). 2024 Apr; 29(9):. doi: 10.3390/molecules29091945. [PMID: 38731436]
  • Sitong Lai, Bing Wang, Kunhui Sun, Fan Li, Qian Liu, Xie-An Yu, Lihe Jiang, Lisheng Wang. Self-Assembled Matrine-PROTAC Encapsulating Zinc(II) Phthalocyanine with GSH-Depletion-Enhanced ROS Generation for Cancer Therapy. Molecules (Basel, Switzerland). 2024 Apr; 29(8):. doi: 10.3390/molecules29081845. [PMID: 38675664]
  • Chu Erfu, Liu Li, Qu Weiting, Chi Tao, Ma Liwei, Yang Hemin, Lu Junkun. Matrine attenuating cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity through improved mitochondrial membrane potential and activation of mitochondrial respiratory chain Complex I pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Apr; 173(?):116464. doi: 10.1016/j.biopha.2024.116464. [PMID: 38503242]
  • Ruiyang Jiang, Zihan Fang, Yueyang Lai, Liu Li, Jiani Tan, Chengtao Yu, Minmin Fan, Lihuiping Tao, Weixing Shen, Changliang Xu, Dongdong Sun, Haibo Cheng. Sophocarpine alleviates intestinal fibrosis via inhibition of inflammation and fibroblast into myofibroblast transition by targeting the Sirt1/p65 signaling axis. European journal of pharmacology. 2024 Mar; 967(?):176318. doi: 10.1016/j.ejphar.2024.176318. [PMID: 38309678]
  • Jinying Lu, Jiang Bian, Yutong Wang, Yan Zhao, Xinmin Zhao, Gao Wang, Jing Yang. Oxymatrine protects articular chondrocytes from IL-1β-induced damage through autophagy activation via AKT/mTOR signaling pathway inhibition. Journal of orthopaedic surgery and research. 2024 Mar; 19(1):178. doi: 10.1186/s13018-024-04667-2. [PMID: 38468339]
  • Zhenting Ding, Ke Wei, Yiwu Zhang, Xueli Ma, Liu Yang, Weiguang Zhang, Huixiang Liu, Chunyan Jia, Weixing Shen, Shencheng Ma, Li Xu, Chenggang Zhou, Yanxue Liu, Shangkun Gao, Yingchao Ji. 'One-Pot' Method Preparation of Dendritic Mesoporous Silica-Loaded Matrine Nanopesticide for Noninvasive Administration Control of Monochamus alternatus: The Vector Insect of Bursapherenchus xylophophilus. ACS biomaterials science & engineering. 2024 Mar; 10(3):1507-1516. doi: 10.1021/acsbiomaterials.3c01270. [PMID: 38372256]
  • Ding Luo, Jia-Wen Zou, Jing-Hao Wang, He Tian, Hua-Yan Xie, Tian-Xi Zhu, Hui-Hui Zhu, Lu-Ming Deng, Chun-Lin Fan, Hao Wang, Guo-Cai Wang, Yu-Bo Zhang. Undescribed matrine-type alkaloids from Sophora alopecuroides with anti-inflammatory activity. Phytochemistry. 2024 Feb; 218(?):113954. doi: 10.1016/j.phytochem.2023.113954. [PMID: 38104747]
  • Jingchun Sun, Xiaoting Wang, Yulin He, Xuekai Tian, Tiantian Yuan, Gongshe Yang, Taiyong Yu. Sophoridine Counteracts Obesity via Src-Mediated Inhibition of VEGFR Expression and PI3K/AKT Phosphorylation. International journal of molecular sciences. 2024 Jan; 25(2):. doi: 10.3390/ijms25021206. [PMID: 38279206]
  • Jingbo Liu, Bingyan Guo, Siying Zhong, Yabing Shi, Zhengping Li, Zhenwu Yu, Zesheng Hao, Li Zhang, Fengyun Li, Yuanhong Wang, Yuxin Li. Novel Evodiamine-Based Sulfonamide Derivatives as Potent Insecticide Candidates Targeting Insect Ryanodine Receptors. Journal of agricultural and food chemistry. 2024 Jan; 72(2):1292-1301. doi: 10.1021/acs.jafc.3c05680. [PMID: 38178001]
  • Ashmita Das, Onkar Kashyap, Devi P Pandey, Surendra H Bodakhe. Oxymatrine impedes the progression of endotoxin-induced glaucoma via redox system modulations. Journal of biochemical and molecular toxicology. 2024 Jan; 38(1):e23631. doi: 10.1002/jbt.23631. [PMID: 38229309]
  • Jiaqi Jin, Zhaofeng Fan, Yonglin Long, Yinping Li, Qian He, Yiming Yang, Weijian Zhong, Disheng Lin, Dawei Lian, Xiao Wang, Jing Xiao, Yang Chen. Matrine induces ferroptosis in cervical cancer through activation of piezo1 channel. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 122(?):155165. doi: 10.1016/j.phymed.2023.155165. [PMID: 37922791]
  • Xiaochuan Tan, Yumei Hao, Nai Ma, Yige Yang, Wenzhen Jin, Ya Meng, Chuchu Zhou, Wensheng Zheng, Yujia Zhang. M6P-modified solid lipid nanoparticles loaded with matrine for the treatment of fibrotic liver. Drug delivery. 2023 Dec; 30(1):2219432. doi: 10.1080/10717544.2023.2219432. [PMID: 37300371]
  • Benjamin Christian Fischer, Yemurai Musengi, Jeannette König, Benjamin Sachse, Stefanie Hessel-Pras, Bernd Schäfer, Carsten Kneuer, Kristin Herrmann. Matrine and Oxymatrine: Evaluating the gene mutation potential using in silico tools and the bacterial reverse mutation assay (Ames test). Mutagenesis. 2023 Oct; ?(?):. doi: 10.1093/mutage/gead032. [PMID: 37877816]
  • Yifei Gao, Chao Wu, Jiaqi Huang, Zhihong Huang, Zhengsen Jin, Siyu Guo, Xiaoyu Tao, Shan Lu, Jingyuan Zhang, Fanqin Zhang, Yiyan Zhai, Rui Shi, Peizhi Ye, Jiarui Wu. A new strategy to identify ADAM12 and PDGFRB as a novel prognostic biomarker for matrine regulates gastric cancer via high throughput chip mining and computational verification. Computers in biology and medicine. 2023 Oct; 166(?):107562. doi: 10.1016/j.compbiomed.2023.107562. [PMID: 37847945]
  • Xi Wang, Wenjing Zhu, Miao Xing, Haiyan Zhu, Enqing Chen, Jie Zhou. Matrine disrupts Nrf2/GPX4 antioxidant system and promotes hepatocyte ferroptosis. Chemico-biological interactions. 2023 Sep; ?(?):110713. doi: 10.1016/j.cbi.2023.110713. [PMID: 37716422]
  • Q Jin, Z Li, Q Xu, Q Liu. Matrine From Sophora Flavescens Attenuates on Collagen-Induced Osteoarthritis by Modulating the Activity of miR-29B-3P/PGRN Axis. Physiological research. 2023 Aug; 72(4):475-483. doi: . [PMID: 37795890]
  • Xingan Cheng, Fangyun Dong, Junjie Li, Qiwen Zou, Xin Liu, Huiqing He, Hanhui Zhang, Xiaojing Lv, Yuehua Wu, Xuhong Jiang, Xiangjing Qin. Synthesis, and biological evaluation of pyrazole matrine derivatives as an insecticide against Spodoptera frugiperda. Pesticide biochemistry and physiology. 2023 Aug; 194(?):105489. doi: 10.1016/j.pestbp.2023.105489. [PMID: 37532351]
  • Shijie Wei, Yubao Zhang, Xiaoran Ma, Yan Yao, Qinqin Zhou, Wenfeng Zhang, Chao Zhou, Jing Zhuang. MAT as a promising therapeutic strategy against triple-negative breast cancer via inhibiting PI3K/AKT pathway. Scientific reports. 2023 07; 13(1):12351. doi: 10.1038/s41598-023-39655-9. [PMID: 37524857]
  • Jinlei Li, Shijie Wei, Davies Marabada, Zhizhong Wang, Qing Huang. Research Progress of Natural Matrine Compounds and Synthetic Matrine Derivatives. Molecules (Basel, Switzerland). 2023 Jul; 28(15):. doi: 10.3390/molecules28155780. [PMID: 37570750]
  • Zhigang Cao, Xiaoya Ling, Panpan Sun, Xiaozhong Zheng, Hua Zhang, Jia Zhong, Wei Yin, Kuohai Fan, Yaogui Sun, Hongquan Li, Na Sun. Matrine Targets Intestinal Lactobacillus acidophilus to Inhibit Porcine Circovirus Type 2 Infection in Mice. International journal of molecular sciences. 2023 Jul; 24(15):. doi: 10.3390/ijms241511878. [PMID: 37569261]
  • Zheng Sun, Bin Zhang, Wenkui Li, Yiwan Zhou, Jing Zhang, Jun Wang, Zhiqing Ma. Matrine can be absorbed and transmitted bidirectionally to defend against aphids (Hemiptera: Aphididae) on wheat and pepper. Pest management science. 2023 Jun; 79(6):2098-2106. doi: 10.1002/ps.7376. [PMID: 36693803]
  • Ding Luo, Xiaoyong Dai, He Tian, Chunlin Fan, Huayan Xie, Nenghua Chen, Jinghao Wang, Laiqiang Huang, Hao Wang, Guocai Wang, Yubo Zhang. Sophflarine A, a novel matrine-derived alkaloid from Sophora flavescens with therapeutic potential for non-small cell lung cancer through ROS-mediated pyroptosis and autophagy. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 May; 116(?):154909. doi: 10.1016/j.phymed.2023.154909. [PMID: 37269775]
  • Swesha Chhabra, Sidharth Mehan. Matrine exerts its neuroprotective effects by modulating multiple neuronal pathways. Metabolic brain disease. 2023 Apr; ?(?):. doi: 10.1007/s11011-023-01214-6. [PMID: 37103719]
  • Jiamei Liu, Yangtian Liu, Bing Liu, Changchun Dai, Peiling Wang, Yanhui Lu. Life-table parameters, functional response, flight ability, and cross-generational effects of matrine demonstrate its safety to Hippodamia variegata (Coleoptera: Coccinellidae). Journal of economic entomology. 2023 Apr; ?(?):. doi: 10.1093/jee/toad068. [PMID: 37075482]
  • Song Ang, Jinfeng Liang, Wende Zheng, Zhen Zhang, Jinxuan Li, Zhenping Yan, Wing-Leung Wong, Kun Zhang, Min Chen, Panpan Wu. Novel Matrine Derivatives as Potential Larvicidal Agents against Aedes albopictus: Synthesis, Biological Evaluation, and Mechanistic Analysis. Molecules (Basel, Switzerland). 2023 Mar; 28(7):. doi: 10.3390/molecules28073035. [PMID: 37049799]
  • Peng Zhang, Ji Zhang, Qiao An, Juan Wang, Ping Yi, Chun-Mao Yuan, Zhong-Kai Zhang, Li-Hua Zhao, Zhan-Xing Hu, Xiao-Jiang Hao. Matrine-Type Alkaloids with Anti-Tomato Spotted Wilt Virus Activity from the Root of Sophora tonkinensis Gagnep. Journal of agricultural and food chemistry. 2023 Mar; 71(10):4394-4407. doi: 10.1021/acs.jafc.2c09003. [PMID: 36854107]
  • Pan Huang, Fan Hu, Zhi-Bo Yang, Yi Pan, Rong Zhou, Yi-Ning Yan, Hai-Zhen Wang, Chang Wang. Matrine regulates Th1/Th2 inflammatory responses by inhibiting the Hsp90/NF-κB signaling axis to alleviate atopic dermatitis. The Kaohsiung journal of medical sciences. 2023 Feb; ?(?):. doi: 10.1002/kjm2.12655. [PMID: 36757049]
  • Yang Li, Bi Wu, Xin Hao, Jian Diao, Jingxin Cao, Ruina Tan, Wei Ma, Ling Ma. Functional analysis of 3 genes in xenobiotic detoxification pathway of Bursaphelenchus xylophilus against matrine. Pesticide biochemistry and physiology. 2023 Feb; 190(?):105334. doi: 10.1016/j.pestbp.2022.105334. [PMID: 36740342]
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