Formononetin (BioDeep_00000398529)

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019

代谢物信息卡片

Formononetin (Biochanin B)

化学式: C16H12O4 (268.0735552)
中文名称: 刺芒柄花素, 芒柄花黄素, 芒柄花黄素, 芒柄花黄素
谱图信息: 最多检出来源 Homo sapiens(blood) 0.06%

分子结构信息

SMILES: COC1=CC=C(C=C1)C1=COC2=C(C=CC(O)=C2)C1=O
InChI: InChI=1/C16H12O4/c1-19-12-5-2-10(3-6-12)14-9-20-15-8-11(17)4-7-13(15)16(14)18/h2-9,17H,1H3

描述信息

Annotation level-1
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D004967 - Estrogens
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.059
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.061
Formononetin is a potent FGFR2 inhibitor with an IC50 of ~4.31 μM. Formononetin potently inhibits angiogenesis and tumor growth[1].
Formononetin is a potent FGFR2 inhibitor with an IC50 of ~4.31 μM. Formononetin potently inhibits angiogenesis and tumor growth[1].

同义名列表

6 个代谢物同义名

Formononetin (Biochanin B); Formononetin; Norberto Lopes; Biochanin B; Flavosil; Formononetol

数据库引用编号

95 个数据库交叉引用编号

ChEBI: CHEBI:18088
KEGG: C00858
PubChem: 5280378
DrugBank: DB15335
ChEMBL: CHEMBL242341
CAS: 485-72-3
MoNA: CCMSLIB00000081282
MoNA: CCMSLIB00000081283
MoNA: VF-NPL-QTOF007721
MoNA: VF-NPL-QTOF007720
MoNA: VF-NPL-QTOF007719
MoNA: VF-NPL-QTOF007718
MoNA: VF-NPL-QTOF007717
MoNA: VF-NPL-QTOF007716
MoNA: VF-NPL-QTOF007715
MoNA: VF-NPL-QTOF007714
MoNA: PR310858
MoNA: PR309182
MoNA: RIKENPlaSMA006548
MoNA: RIKENPlaSMA006543
MoNA: RIKENPlaSMA006538
MoNA: RIKENPlaSMA006533
MoNA: RIKENPlaSMA006528
MoNA: RIKENPlaSMA006523
MoNA: RIKENPlaSMA006518
MoNA: RIKENPlaSMA006514
MoNA: RIKENPlaSMA006509
MoNA: RIKENPlaSMA006504
MoNA: RIKENPlaSMA006499
MoNA: RIKENPlaSMA006495
MoNA: RIKENPlaSMA002858
MoNA: RIKENPlaSMA002853
MoNA: RIKENPlaSMA002848
MoNA: RIKENPlaSMA002843
MoNA: RIKENPlaSMA002838
MoNA: RIKENPlaSMA002833
MoNA: RIKENPlaSMA002828
MoNA: RIKENPlaSMA002823
MoNA: RIKENPlaSMA002818
MoNA: RIKENPlaSMA002813
MoNA: RIKENPlaSMA002808
MoNA: RIKENPlaSMA002803
MoNA: VF-NPL-LTQ007154
MoNA: VF-NPL-LTQ007152
MoNA: VF-NPL-LTQ007151
MoNA: VF-NPL-LTQ003710
MoNA: VF-NPL-LTQ003709
MoNA: VF-NPL-LTQ003708
MoNA: VF-NPL-LTQ003707
MoNA: VF-NPL-QEHF013965
MoNA: VF-NPL-QEHF013964
MoNA: VF-NPL-QEHF013963
MoNA: VF-NPL-QEHF013962
MoNA: VF-NPL-QEHF013961
MoNA: VF-NPL-QEHF013960
MoNA: VF-NPL-QEHF013959
MoNA: VF-NPL-QEHF013958
MoNA: VF-NPL-QEHF013957
MoNA: VF-NPL-QEHF013320
MoNA: VF-NPL-QEHF013319
MoNA: VF-NPL-QEHF013318
MoNA: VF-NPL-QEHF013317
MoNA: VF-NPL-QEHF013316
MoNA: VF-NPL-QEHF013315
MoNA: PM001307
MoNA: PM019109
MoNA: PM019127
MoNA: PM008228
MoNA: PM002117
MoNA: PM011508
MoNA: MetaboBASE0360
MoNA: MetaboBASE0359
MoNA: MetaboBASE0358
MoNA: MetaboBASE0357
MoNA: MetaboBASE0356
MoNA: MetaboBASE0355
MoNA: PT206800
MoNA: PT106800
MoNA: BML81258
MoNA: BML81257
MoNA: BML81256
MoNA: BML81255
MoNA: BML00230
MoNA: BML00217
MoNA: BML00204
MoNA: BML00177
MoNA: BML00163
PubChem: 4115
LipidMAPS: LMPK12050037
KNApSAcK: C00002525
3DMET: B00192
NIKKAJI: J12.525C
RefMet: Formononetin
medchemexpress: HY-N0183
BioNovoGene_Lab2019: BioNovoGene_Lab2019-692

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

177 个相关的物种来源信息

64040 - Actaea racemosa:
149628 - Amburana cearensis: 10.1590/S0103-50532010000900022
126911 - Ammopiptanthus mongolicus:
48131 - Amorpha fruticosa:
53825 - Andira inermis:
3818 - Arachis hypogaea: 10.1111/J.1365-3059.1995.TB01679.X
1009002 - Ardisia paniculata: 10.1016/J.BMC.2008.12.033
1460044 - Astragalus clusii: 10.1007/978-1-4615-3476-1_53
339489 - Astragalus glaux: 10.1007/978-1-4615-3476-1_53
649199 - Astragalus membranaceus:
119829 - Astragalus mongholicus:
313911 - Baptisia alba:
149633 - Baptisia australis:
313912 - Baptisia bracteata:
1969220 - Baptisia calycosa:
313913 - Baptisia cinerea:
1969221 - Baptisia lanceolata:
1969222 - Baptisia lecontei:
1969223 - Baptisia megacarpa:
1871516 - Baptisia perfoliata:
1969224 - Baptisia simplicifolia:
313914 - Baptisia sphaerocarpa:
49797 - Baptisia tinctoria:
56060 - Butea monosperma:
480422 - Butea superba: 10.3987/COM-05-10350
185709 - Callerya cinerea:
1505188 - Callerya dielsiana:
626677 - Caragana conferta: 10.1007/S10600-010-9725-Z
220690 - Caragana microphylla: 10.1007/S10600-007-0083-4
24962 - Castanospermum australe: 10.1071/CH9630188
500180 - Centrolobium robustum:
500181 - Centrolobium sclerophyllum:
500182 - Centrolobium tomentosum:
185703 - Centrosema pubescens: 10.1515/ZNC-1980-11-1208
167617 - Centrosema virginianum: 10.1515/ZNC-1980-11-1208
242878 - Cicer anatolicum: 10.1016/S0031-9422(97)00798-X
3827 - Cicer arietinum:
90899 - Cicer bijugum:
200948 - Cicer canariense:
107682 - Cicer chorassanicum:
92720 - Cicer cuneatum:
90897 - Cicer echinospermum:
242867 - Cicer flexuosum:
92719 - Cicer judaicum:
200949 - Cicer macracanthum:
224826 - Cicer microphyllum:
242879 - Cicer montbretii:
242870 - Cicer nuristanicum:
242871 - Cicer oxyodon:
47088 - Cicer pinnatifidum:
242872 - Cicer pungens:
380786 - Cicer rechingeri:
90898 - Cicer reticulatum:
242873 - Cicer songaricum:
242877 - Cicer tragacanthoides: 10.1007/BF00629810
92718 - Cicer yamashitae:
38412 - Cladrastis kentukea: 10.1016/S0040-4020(01)82920-3
53857 - Cladrastis sikokiana: 10.1016/S0040-4020(01)82920-3
384038 - Cyclopia intermedia: 10.1021/JF980258X
337842 - Cyclopia sessiliflora: 10.1533/9781845698188.5.242
1353437 - Dalbergia baronii:
1353443 - Dalbergia candenatensis:
1353446 - Dalbergia cearensis:
862910 - Dalbergia cultrata: 10.1021/NP0302450
450024 - Dalbergia ecastaphyllum:
450026 - Dalbergia frutescens:
1353457 - Dalbergia inundata:
1225666 - Dalbergia lanceolaria:
450027 - Dalbergia monetaria:
298683 - Dalbergia nigrescens: 10.1021/NP0302450
1265830 - Dalbergia nitidula:
499988 - Dalbergia odorifera:
1030150 - Dalbergia oliveri: 10.1016/J.PHYTOCHEM.2003.08.010
1353466 - Dalbergia parviflora:
2507847 - Dalbergia sissoides: 10.3906/KIM-1206-45
107308 - Dalbergia sissoo: 10.1021/NP070478H
1353472 - Dalbergia spruceana:
1966414 - Dalbergia stevensonii:
1544813 - Dalbergia volubilis:
149639 - Dermatophyllum secundiflorum:
1225674 - Derris cuneifolia:
238419 - Echinospartum horridum: 10.1016/S0031-9422(00)94255-9
244311 - Erigeron Breviscapus: -
256638 - Euchresta formosana:
457900 - Eysenhardtia polystachya: 10.1300/J044V07N02_03
132443 - Fordia cauliflora: 10.1016/J.CCLET.2010.03.021
147456 - Genista sessilifolia: 10.1007/S10600-009-9248-7
167663 - Gliricidia sepium: 10.1016/S0031-9422(97)00517-7
3846 - Glycine: 10.1207/S15327914NC5402_5
3847 - Glycine max:
46348 - Glycyrrhiza echinata:
49827 - Glycyrrhiza glabra:
49827 - Glycyrrhiza glabra L.: -
74614 - Glycyrrhiza inflata:
74614 - Glycyrrhiza inflata Bat.: -
74859 - Glycyrrhiza pallidiflora:
74613 - Glycyrrhiza uralensis:
74613 - Glycyrrhiza uralensis Fisch.: -
648866 - Grona styracifolia: 10.1016/J.PHYTOCHEM.2007.02.015
119828 - Hedysarum polybotrys: 10.1248/CPB.32.3267
2419554 - Hedysarum theinum:
3860 - Lathyrus sativus: 10.1007/BF00630331
37501 - Maackia amurensis:
53896 - Maackia floribunda: 10.1248/CPB.20.2488
2654228 - Machaerium aristulatum:
450031 - Machaerium brasiliense:
70936 - Medicago arabica: 10.1016/0305-1978(82)90048-5
70952 - Medicago laciniata: 10.1016/S0305-1978(96)00101-9
70963 - Medicago orthoceras: 10.1016/S0305-1978(96)00101-9
70965 - Medicago polyceratia: 10.1016/S0305-1978(96)00101-9
70968 - Medicago radiata: 10.1016/0305-1978(82)90048-5
3879 - Medicago sativa:
3880 - Medicago truncatula:
1279044 - Melilotus messanensis: 10.1016/S0031-9422(98)00453-1
62119 - Millettia dura:
1712206 - Millettia leucantha:
53906 - Myroxylon balsamum: 10.1016/S0031-9422(00)89391-7
3882 - Onobrychis viciifolia: 10.1016/S0031-9422(00)91022-7
798039 - Ononis speciosa:
58890 - Ononis spinosa:
1479707 - Oxytropis falcata: 10.1021/NP100339U
1929974 - Pericopsis laxiflora: 10.1039/P19760000186
3888 - Pisum sativum: 10.1016/0031-9422(81)80130-6
33090 - Plants: -
56065 - Pongamia pinnata: 10.1016/J.BMCL.2014.11.015
100170 - Pterocarpus indicus:
1071187 - Pterocarpus marsupium:
1071200 - Pterocarpus soyauxii:
3893 - Pueraria montana var. lobata:
224864 - Pycnanthus angolensis: 10.1021/NP9007393
49840 - Sophora flavescens:
49840 - SophorA flavescens Ait.: -
256637 - Sophora tomentosa:
455371 - Spatholobus suberectus: 10.1016/J.PHYTOCHEM.2006.05.008
455371 - Spatholobus Suberectus Dunn: -
3897 - Styphnolobium japonicum:
450104 - Swartzia polyphylla: 10.1248/CPB.40.2970
334483 - Syzygium jambos: 10.1002/(SICI)1099-1565(199707)8:4<176::AID-PCA351>3.0.CO;2-K
754915 - Taverniera abyssinica: 10.1016/S0031-9422(98)00066-1
2785040 - Tephrosia maxima: 10.1021/NP50042A015
49853 - Thermopsis fabacea: 10.1248/CPB.28.3686
114320 - Thermopsis lanceolata: 10.1248/CPB.28.3686
114322 - Thermopsis macrophylla: 10.1016/S0031-9422(00)88458-7
2805045 - Thermopsis mollis: 10.1016/S0031-9422(00)88458-7
61122 - Thermopsis rhombifolia: 10.1016/S0031-9422(00)88458-7
114325 - Thermopsis villosa: 10.1016/S0031-9422(00)88458-7
54894 - Tipuana tipu:
97007 - Trifolium alpestre:
361560 - Trifolium arvense: 10.1016/J.TALANTA.2009.03.011
97023 - Trifolium fragiferum: 10.1021/JF00049A020
60916 - Trifolium incarnatum:
97028 - Trifolium medium: 10.1016/J.TALANTA.2009.03.011
74522 - Trifolium montanum: 10.1021/JF00049A020
97032 - Trifolium pannonicum: 10.1016/J.TALANTA.2009.03.011
361972 - Trifolium polyphyllum: 10.1007/BF00577206
57577 - Trifolium pratense:
3899 - Trifolium repens:
97036 - Trifolium resupinatum: 10.1007/S10600-007-0206-Y
97037 - Trifolium rubens: 10.1016/J.TALANTA.2009.03.011
3900 - Trifolium subterraneum:
200959 - Trifolium willdenovii: 10.1007/BF00564617
390135 - Trigonella anguina: 10.1016/0305-1978(82)90048-5
119380 - Trigonella arabica: 10.1016/S0305-1978(96)00101-9
1210108 - Trigonella cylindracea: 10.1016/S0305-1978(96)00101-9
78534 - Trigonella foenum-graecum:
390136 - Trigonella glabra: 10.1016/S0305-1978(96)00101-9
1210111 - Trigonella maritima:
119386 - Trigonella spicata: 10.1016/0305-1978(82)90048-5
119388 - Trigonella stellata: 10.1016/S0305-1978(96)00101-9
157791 - Vigna radiata: 10.1007/BF00633405
3916 - Vigna radiata var. radiata: 10.1007/BF00633405
58847 - Virgilia oroboides:
224910 - Virola surinamensis:
185975 - Wisteria brachybotrys:
54882 - Wisteriopsis reticulata: 10.1021/JF903216R
318068 - Xanthium strumarium: 10.1007/S10600-006-0215-2
1231576 - Zollernia paraensis: 10.1016/0031-9422(83)80106-X

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Hao-Tian Xu, Qi Zheng, Zong-Guang Tai, Wen-Cheng Jiang, Shao-Qiong Xie, Yue Luo, Xiao-Ya Fei, Ying Luo, Xin Ma, Le Kuai, Ying Zhang, Rui-Ping Wang, Bin Li, Quan-Gang Zhu, Jian-Kun Song. Formononetin attenuates psoriasiform inflammation by regulating interferon signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155412. doi: 10.1016/j.phymed.2024.155412. [PMID: 38579666]
Palash Mandal, David A Mortensen, André F Brito, Anna K Wallingford, Marta R M Lima, Nicholas D Warren, Richard G Smith. Water Stress Influences Phytoestrogen Levels in Red Clover (Trifolium pratense) but Not Kura Clover (T. ambiguum). Journal of agricultural and food chemistry. 2024 May; 72(18):10247-10256. doi: 10.1021/acs.jafc.4c00300. [PMID: 38683760]
Jie Luo, Youde Cai, Dingling Wei, Liping Cao, Qiansong He, Yuanhua Wu. Formononetin alleviates cerebral ischemia-reperfusion injury in rats by targeting the PARP-1/PARG/Iduna signaling pathway. Brain research. 2024 Apr; 1829(?):148845. doi: 10.1016/j.brainres.2024.148845. [PMID: 38452845]
Haipeng Chen, Yanmei Lou, Senyi Lin, Xuanjing Tan, Yuting Zheng, Hong Yu, Ruidi Jiang, Yijie Wei, Huijie Huang, Xiaoxiao Qi, Rong Zhang, Zhongqiu Liu, Jinjun Wu. Formononetin, a bioactive isoflavonoid constituent from Astragalus membranaceus (Fisch.) Bunge, ameliorates type 1 diabetes mellitus via activation of Keap1/Nrf2 signaling pathway: An integrated study supported by network pharmacology and experimental validation. Journal of ethnopharmacology. 2024 Mar; 322(?):117576. doi: 10.1016/j.jep.2023.117576. [PMID: 38104880]
Ying He, Youde Cai, Dingling Wei, Liping Cao, Qiansong He, Yazhou Zhang. Elucidating the mechanisms of formononetin in modulating atherosclerotic plaque formation in ApoE-/- mice. BMC cardiovascular disorders. 2024 Feb; 24(1):121. doi: 10.1186/s12872-024-03774-6. [PMID: 38388385]
Jiabao Liao, Xuehua Xie, Ning Wang, Yuming Wang, Jie Zhao, Feng Chen, Fei Qu, Weibo Wen, Jing Miao, Huantian Cui. Formononetin promotes fatty acid β-oxidation to treat non-alcoholic steatohepatitis through SIRT1/PGC-1α/PPARα pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Feb; 124(?):155285. doi: 10.1016/j.phymed.2023.155285. [PMID: 38185065]
Xiaomei Li, Xianhan Jiang, Runhao Zeng, Xiujuan Lai, Jing Wang, Hao Liu, Huihui Wu, Jiaxun He, Lian Liu, Zhiying Zhu, Jingpei Li, Xue Liang. Formononetin attenuates cigarette smoke-induced COPD in mice by suppressing inflammation, endoplasmic reticulum stress, and apoptosis in bronchial epithelial cells via AhR/CYP1A1 and AKT/mTOR signaling pathways. Phytotherapy research : PTR. 2024 Jan; ?(?):. doi: 10.1002/ptr.8104. [PMID: 38191199]
Mi Li, Chengzhi Jiang, Jianting Chen, Junyan Wang. [Formononetin enhances the antitumor effect of H22 hepatoma transplanted mice]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2023 Dec; 39(12):1063-1068. doi: . [PMID: 38140864]
Liang Zhang, Qian Wu, Yuying Huang, Jun Zheng, Sheng Guo, Li He. Formononetin ameliorates airway inflammation by suppressing ESR1/NLRP3/Caspase-1 signaling in asthma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Dec; 168(?):115799. doi: 10.1016/j.biopha.2023.115799. [PMID: 37922653]
Wen Jiang, Ting Hu, Chen Ye, Man Hu, Qingqing Yu, Lijuan Sun, Jichao Liang, Yong Chen. Formononetin attenuates high glucose-induced neurotoxicity by negatively regulating oxidative stress and mitochondrial dysfunction in Schwann cells via activation of SIRT3. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 Nov; 182(?):114156. doi: 10.1016/j.fct.2023.114156. [PMID: 37944786]
Yu-Zhu Yang, Tao Wang, Qi-Lei Chen, Hu-Biao Chen, Qian-Song He, Ya-Zhou Zhang. Identification of the Metabolites of Both Formononetin in Rat Hepatic S9 and Ononin in Rat Urine Samples and Preliminary Network Pharmacology Evaluation of Their Main Metabolites. Molecules (Basel, Switzerland). 2023 Nov; 28(21):. doi: 10.3390/molecules28217451. [PMID: 37959870]
Zhijing Zhou, Peng Zhang. Formononetin ameliorates the LPS-induced inflammatory response and apoptosis of neuronal cells via NF-κB/NLRP3 signaling pathway. Functional & integrative genomics. 2023 Oct; 23(4):321. doi: 10.1007/s10142-023-01247-1. [PMID: 37847432]
Chun Li, Yuxin Xie, Shaoyu Hu, Hong Yu, Yunke Xu, Hongping Shen, Yuan Yuan, Long Gu, Bangming Pu. Identification of formononetin as the active compound of CR-SR in hepatocellular carcinoma treatment: An integrated approach combining network pharmacology and weighted gene co-expression networks. Chemical biology & drug design. 2023 Oct; ?(?):. doi: 10.1111/cbdd.14363. [PMID: 37793997]
Zi-Wen Zhou, Xue-Yan Zhu, Shu-Ying Li, Si-En Lin, Yu-Han Zhu, Kunmei Ji, Jia-Jie Chen. Formononetin Inhibits Mast Cell Degranulation to Ameliorate Compound 48/80-Induced Pseudoallergic Reactions. Molecules (Basel, Switzerland). 2023 Jul; 28(13):. doi: 10.3390/molecules28135271. [PMID: 37446928]
Tanvi Dayanand Pingale, Girdhari Lal Gupta. Acute & sub-acute toxicity study reveals no dentrimental effect of formononetin in mice upon repeated i.p. dosing. Toxicology mechanisms and methods. 2023 Jul; ?(?):1-17. doi: 10.1080/15376516.2023.2234026. [PMID: 37415263]
Chunhua Zhang, Lingyun Hu, Yun Xie, Jing Wen, Yadi Chen. [Formononetin improves cognitive behavior in aging rats with chronic unpredictable mild in hippocampal tissue stress by blocking the NF-κB pathway and inhibiting the release of inflammatory factors]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2023 Jul; 39(7):610-616. doi: . [PMID: 37403720]
Xin Yu, Binkui Yang, Bin Chen, Qi Wu, Zhengrong Ren, Dongsheng Wang, Tao Yuan, Hao Ding, Chao Ding, Yang Liu, Lei Zhang, Zhongyang Sun, Jianning Zhao. Inhibitory effects of Formononetin on CoCrMo particle-induced osteoclast activation and bone loss through downregulating NF-κB and MAPK signaling. Cellular signalling. 2023 Jun; 106(?):110651. doi: 10.1016/j.cellsig.2023.110651. [PMID: 36894124]
Lan-Fang Zhang, Xiao-Yan Zhang, Ai-Cheng Wang, Yi-Jia Feng, Xiao-Ming Qi, Yuan-Lin Zhang, Qing-Fang Li, Yuan-Biao Qiao, Qing-Shan Li. Bidirectional crosstalk of the cAMP/ROS-dependent signaling pathways in inflammatory macrophage: An activation of formononetin. Toxicology and applied pharmacology. 2023 Jun; ?(?):116571. doi: 10.1016/j.taap.2023.116571. [PMID: 37269934]
Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
Gereltsetseg Enkhbat, Kevin J Foster, Phillip G H Nichols, William Erskine, Yoshiaki Inukai, Megan H Ryan. Leaf formononetin content of Trifolium subterraneum increases in response to waterlogging but its proportion of total isoflavones is little changed. Functional plant biology : FPB. 2023 May; ?(?):. doi: 10.1071/fp22151. [PMID: 37142401]
Bingwen Zhu, Yufang Ni, Yi Gong, Xiaoshuang Kang, Huaiying Guo, Xiaoheng Liu, Jianchun Li, Li Wang. Formononetin ameliorates ferroptosis-associated fibrosis in renal tubular epithelial cells and in mice with chronic kidney disease by suppressing the Smad3/ATF3/SLC7A11 signaling. Life sciences. 2023 Feb; 315(?):121331. doi: 10.1016/j.lfs.2022.121331. [PMID: 36586573]
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