AS 2-3 (BioDeep_00000396455)

Main id: BioDeep_00000008156

 

PANOMIX_OTCML-2023


代谢物信息卡片


FURO(3,4:6,7)NAPHTHO(2,3-D)-1,3-DIOXOL-6(5AH)-ONE, 5,8,8A,9-TETRAHYDRO-5-(3,4,5-TRIMETHOXYPHENYL)-, (5R-(5.ALPHA.,5A.BETA.,8A.ALPHA.))- PODOPHYLLOTOXIN, DEOXY-

化学式: C22H22O7 (398.1365)
中文名称: 脱氧鬼臼毒素, 去氧鬼臼毒素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=CC(=CC(=C1OC)OC)C2C3C(CC4=CC5=C(C=C24)OCO5)COC3=O
InChI: InChI=1S/C22H22O7/c1-24-17-6-12(7-18(25-2)21(17)26-3)19-14-8-16-15(28-10-29-16)5-11(14)4-13-9-27-22(23)20(13)19/h5-8,13,19-20H,4,9-10H2,1-3H3/t13-,19+,20-/m0/s1

描述信息

Deoxypodophyllotoxin is a member of the class of furonaphthodioxoles that is (5R,5aR,8aR)-5,8,8a,9-tetrahydro-2H-furo[3,4:6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one substituted at position 5 by a 3,4,5-trimethoxyphenyl group. It has a role as a plant metabolite, an antineoplastic agent and an apoptosis inducer. It is a lignan, a furonaphthodioxole, a gamma-lactone and a member of methoxybenzenes.
Deoxypodophyllotoxin is a natural product found in Austrocedrus chilensis, Libocedrus bidwillii, and other organisms with data available.
A member of the class of furonaphthodioxoles that is (5R,5aR,8aR)-5,8,8a,9-tetrahydro-2H-furo[3,4:6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one substituted at position 5 by a 3,4,5-trimethoxyphenyl group.
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
D007155 - Immunologic Factors > D018796 - Immunoconjugates
D007155 - Immunologic Factors > D007136 - Immunoglobulins
D007155 - Immunologic Factors > D000906 - Antibodies
D009676 - Noxae > D000922 - Immunotoxins
Deoxypodophyllotoxin (DPT), a derivative of podophyllotoxin, is a lignan with potent antimitotic, anti-inflammatory and antiviral properties isolated from Anthriscus sylvestris. Deoxypodophyllotoxin, targets the microtubule, has a major impact in oncology not only as anti-mitotics but also as potent inhibitors of angiogenesis[1]. Deoxypodophyllotoxin induces cell autophagy and apoptosis[2]. Deoxypodophyllotoxin evokes increase of intracellular Ca2+ concentrations in DRG neurons[3].
Deoxypodophyllotoxin (DPT), a derivative of podophyllotoxin, is a lignan with potent antimitotic, anti-inflammatory and antiviral properties isolated from Anthriscus sylvestris. Deoxypodophyllotoxin, targets the microtubule, has a major impact in oncology not only as anti-mitotics but also as potent inhibitors of angiogenesis[1]. Deoxypodophyllotoxin induces cell autophagy and apoptosis[2]. Deoxypodophyllotoxin evokes increase of intracellular Ca2+ concentrations in DRG neurons[3].

同义名列表

39 个代谢物同义名

FURO(3,4:6,7)NAPHTHO(2,3-D)-1,3-DIOXOL-6(5AH)-ONE, 5,8,8A,9-TETRAHYDRO-5-(3,4,5-TRIMETHOXYPHENYL)-, (5R-(5.ALPHA.,5A.BETA.,8A.ALPHA.))- PODOPHYLLOTOXIN, DEOXY-; (10R,11R,15R)-10-(3,4,5-trimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.03,7,011,15]hexadeca-1(9),2,7-trien-12-one; Furo(3,4:6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)-, (5R,5aR,8aR)-; Furo[3,4:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)-, (5R,5aR,8aR)-; (5R,5aR,8aR)-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydro-2H-furo[3,4:6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one; (5R,5aR,8aR)-5-(3,4,5-Trimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3,4:6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one; (5R,5AR,8AR)-5,8,8A,9-TETRAHYDRO-5-(3,4,5-TRIMETHOXYPHENYL)FURO(3,4:6,7)NAPHTHO(2,3-D)-1,3-DIOXOL-6(5AH)-ONE; (5R,5aR,8aR)-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3,4:6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one; Furo[3,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)-,(5R,5aR,8aR)-; (5R,5aR,8aR)-5-(3,4,5-Trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3,4:6,7]naphtho[2,3-d][1,3]dioxol-6(5a)-one; (5R,5aR,8aR)-5-(3,4,5-trimethoxyphenyl)-5a,8,8a,9-tetrahydro-5H-isobenzofuro[5,6-f][1,3]benzodioxol-6-one; (5R,5aR,8aR)-5-(3,4,5-trimethoxyphenyl)-5a,8,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-6-one; 5,8,8a,9,-Tetrahydro-5-(3,4,5-trimethoxyphenyl)furo[3,4:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one; deoxypodophyllotoxin, (5R-(5alpha,5aalpha,8aalpha))-isomer; deoxypodophyllotoxin, (5alpha,5aalpha,8aalpha)-(+-)-isomer; deoxypodophyllotoxin, (5R-(5alpha,5aalpha,8abeta))-isomer; deoxypodophyllotoxin, (5R-(5alpha,5abeta,8aalpha))-isomer; deoxypodophyllotoxin, (5alpha,5aalpha,8abeta)-(+-)-isomer; deoxypodophyllotoxin, (5R-(5alpha,5abeta,8abeta))-isomer; Deoxypodophyllotoxin (Anthricin); Podophyllotoxin, 7CI, 8CI); (-)-Desoxypodophyllotoxin; (-)-Deoxypodophyllotoxin; isodeoxypodophyllotoxin; 4-Deoxypodophyllotoxin; deoxypicropodophyllin; Desoxypodophyllotoxin; Deoxypodophyllotoxin; (-)-Anthricin; isoanthricin; NCI60_003794; Silicicolin; Anthriscin; Hernandion; 45NR8XYU1L; Anthricin; Hernandin; AS 2-3; Deoxypodophyllotoxin



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

39 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 17 ANG, ANXA5, BCL2, BCL2L1, CASP3, CCNB1, CDC25C, CDK1, CYP2C9, CYP3A4, EGFR, MAPK14, MTOR, PIK3CA, PTEN, SGCB, TUBB4B
Peripheral membrane protein 2 ANXA5, MTOR
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 6 BCL2, CDK1, CYP2C9, CYP3A4, EGFR, MTOR
Mitochondrion membrane 1 BCL2L1
Nucleus 12 ANG, BCL2, CASP3, CCNB1, CDC25C, CDK1, EGFR, MAPK14, MTOR, PARP1, PTEN, TUBB4B
cytosol 14 ANG, ANXA5, BCL2, BCL2L1, CASP3, CCNB1, CDC25C, CDK1, MAPK14, MTOR, PARP1, PIK3CA, PTEN, TUBB4B
dendrite 1 MTOR
nuclear body 1 PARP1
phagocytic vesicle 1 MTOR
centrosome 3 BCL2L1, CCNB1, CDK1
nucleoplasm 8 CASP3, CCNB1, CDC25C, CDK1, MAPK14, MTOR, PARP1, PTEN
Cell membrane 1 EGFR
Cytoplasmic side 2 BCL2L1, MTOR
lamellipodium 1 PIK3CA
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Golgi apparatus membrane 1 MTOR
cell junction 1 EGFR
cell surface 1 EGFR
glutamatergic synapse 3 CASP3, EGFR, MAPK14
Golgi membrane 2 EGFR, MTOR
growth cone 1 ANG
lysosomal membrane 1 MTOR
mitochondrial inner membrane 1 BCL2L1
neuronal cell body 2 ANG, CASP3
sarcolemma 2 ANXA5, SGCB
Cytoplasm, cytosol 2 BCL2L1, PARP1
Lysosome 1 MTOR
endosome 1 EGFR
plasma membrane 5 CYP2C9, EGFR, PIK3CA, PTEN, SGCB
synaptic vesicle membrane 1 BCL2L1
Membrane 8 ANXA5, BCL2, CCNB1, CDK1, CYP3A4, EGFR, MTOR, PARP1
apical plasma membrane 2 EGFR, PTEN
axon 1 CCK
basolateral plasma membrane 1 EGFR
extracellular exosome 3 ANXA5, CDK1, TUBB4B
Lysosome membrane 1 MTOR
endoplasmic reticulum 2 BCL2, BCL2L1
extracellular space 3 ANG, CCK, EGFR
perinuclear region of cytoplasm 3 CDC25C, EGFR, PIK3CA
intercalated disc 1 PIK3CA
mitochondrion 5 BCL2, BCL2L1, CDK1, MAPK14, PARP1
protein-containing complex 3 BCL2, EGFR, PARP1
intracellular membrane-bounded organelle 2 CYP2C9, CYP3A4
Microsome membrane 3 CYP2C9, CYP3A4, MTOR
postsynaptic density 2 CASP3, PTEN
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 EGFR
Secreted 2 ANG, CCK
extracellular region 6 ANG, ANXA5, CCK, MAPK14, PTEN, TUBB4B
cytoplasmic side of plasma membrane 1 PTEN
Mitochondrion outer membrane 3 BCL2, BCL2L1, MTOR
Single-pass membrane protein 2 BCL2, BCL2L1
mitochondrial outer membrane 3 BCL2, BCL2L1, MTOR
Mitochondrion matrix 1 BCL2L1
mitochondrial matrix 3 BCL2L1, CCNB1, CDK1
transcription regulator complex 1 PARP1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 BCL2L1, CDK1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 BCL2L1
Nucleus membrane 2 BCL2, BCL2L1
Bcl-2 family protein complex 2 BCL2, BCL2L1
nuclear membrane 3 BCL2, BCL2L1, EGFR
external side of plasma membrane 1 ANXA5
Extracellular vesicle 1 TUBB4B
actin cytoskeleton 1 ANG
dendritic spine 1 PTEN
microtubule cytoskeleton 1 TUBB4B
nucleolus 2 ANG, PARP1
midbody 1 CDK1
Single-pass type II membrane protein 1 SGCB
Cell membrane, sarcolemma 1 SGCB
Membrane raft 1 EGFR
pore complex 1 BCL2
Cytoplasm, cytoskeleton 2 SGCB, TUBB4B
focal adhesion 2 ANXA5, EGFR
microtubule 1 TUBB4B
basement membrane 1 ANG
intracellular vesicle 1 EGFR
Cell projection, dendritic spine 1 PTEN
Nucleus, PML body 2 MTOR, PTEN
PML body 2 MTOR, PTEN
mitochondrial intermembrane space 1 CDC25C
collagen-containing extracellular matrix 1 ANXA5
nuclear speck 1 MAPK14
receptor complex 1 EGFR
Cell projection, neuron projection 1 PTEN
Zymogen granule membrane 1 ANXA5
neuron projection 1 PTEN
chromatin 1 PARP1
cell projection 1 PTEN
mitotic spindle 2 CDK1, TUBB4B
Chromosome 2 ANG, PARP1
cytoskeleton 2 SGCB, TUBB4B
Nucleus, nucleolus 2 ANG, PARP1
spindle pole 2 CCNB1, MAPK14
nuclear replication fork 1 PARP1
chromosome, telomeric region 2 CDK1, PARP1
site of double-strand break 1 PARP1
intercellular bridge 1 TUBB4B
Cytoplasm, cytoskeleton, flagellum axoneme 1 TUBB4B
sperm flagellum 1 TUBB4B
nuclear envelope 2 MTOR, PARP1
Endomembrane system 1 MTOR
axonemal microtubule 1 TUBB4B
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
myelin sheath 1 BCL2
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
endocytic vesicle 1 ANG
Schmidt-Lanterman incisure 1 PTEN
azurophil granule lumen 1 TUBB4B
outer kinetochore 1 CCNB1
vesicle membrane 1 ANXA5
clathrin-coated endocytic vesicle membrane 1 EGFR
protein-DNA complex 1 PARP1
spindle microtubule 1 CDK1
death-inducing signaling complex 1 CASP3
dystrophin-associated glycoprotein complex 1 SGCB
sarcoglycan complex 1 SGCB
Cytoplasmic vesicle, phagosome 1 MTOR
site of DNA damage 1 PARP1
cyclin-dependent protein kinase holoenzyme complex 1 CDK1
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
angiogenin-PRI complex 1 ANG
cyclin A1-CDK1 complex 1 CDK1
cyclin A2-CDK1 complex 1 CDK1
cyclin B1-CDK1 complex 2 CCNB1, CDK1
myelin sheath adaxonal region 1 PTEN
endothelial microparticle 1 ANXA5
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
[Isoform alpha]: Secreted 1 PTEN
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[Isoform Bcl-X(L)]: Mitochondrion inner membrane 1 BCL2L1


文献列表

  • Keisuke Kobayashi, Masaomi Yamamura, Bunzo Mikami, Akira Shiraishi, Masato Kumatani, Honoo Satake, Eiichiro Ono, Toshiaki Umezawa. Anthriscus sylvestris Deoxypodophyllotoxin Synthase Involved in Podophyllotoxin Biosynthesis. Plant & cell physiology. 2023 Oct; ?(?):. doi: 10.1093/pcp/pcad103. [PMID: 37948767]
  • Haoyu Tang, Min-Hao Wu, Hsiao-Yu Lin, Meng-Ru Han, Yueh-Hua Tu, Zhi-Jie Yang, Tun-Cheng Chien, Nei-Li Chan, Wei-Chen Chang. Mechanistic analysis of carbon-carbon bond formation by deoxypodophyllotoxin synthase. Proceedings of the National Academy of Sciences of the United States of America. 2022 01; 119(1):. doi: 10.1073/pnas.2113770119. [PMID: 34969844]
  • Davide Decembrino, Alessandra Raffaele, Ronja Knöfel, Marco Girhard, Vlada B Urlacher. Synthesis of (-)-deoxypodophyllotoxin and (-)-epipodophyllotoxin via a multi-enzyme cascade in E. coli. Microbial cell factories. 2021 Sep; 20(1):183. doi: 10.1186/s12934-021-01673-5. [PMID: 34544406]
  • Ya-Nan Li, Ni Ning, Lei Song, Yun Geng, Jun-Ting Fan, Chao-Ying Ma, He-Zhong Jiang. Derivatives of Deoxypodophyllotoxin Induce Apoptosis through Bcl-2/Bax Proteins Expression. Anti-cancer agents in medicinal chemistry. 2021; 21(5):611-620. doi: 10.2174/1871520620999200730160952. [PMID: 32748757]
  • Chang Zu, Yinglan Yu, Caiwei Yu, Yi Li, Runing Sun, Birendra Chaurasiya, Baoqiang Tang, Daquan Chen, Jiasheng Tu, Yan Shen. Highly loaded deoxypodophyllotoxin nano-formulation delivered by methoxy polyethylene glycol-block-poly (D,L-lactide) micelles for efficient cancer therapy. Drug delivery. 2020 Dec; 27(1):248-257. doi: 10.1080/10717544.2020.1716875. [PMID: 32003255]
  • Eman Al-Sayed, Tzu-Yi Ke, Tsong-Long Hwang, Shu-Rong Chen, Michal Korinek, Shu-Li Chen, Yuan-Bin Cheng. Cytotoxic and anti-inflammatory effects of lignans and diterpenes from Cupressus macrocarpa. Bioorganic & medicinal chemistry letters. 2020 05; 30(10):127127. doi: 10.1016/j.bmcl.2020.127127. [PMID: 32223924]
  • Yilin Qiao, Nathan K Sunada, Alyssa E Hatada, Ingo Lange, Manana Khutsishvili, Valida Alizade, Daniel Atha, Dana-Lynn Ko'omoa-Lange, Robert P Borris. Potential anti-neuroblastoma agents from Juniperus oblonga. Biochemical and biophysical research communications. 2019 08; 516(3):733-738. doi: 10.1016/j.bbrc.2019.06.123. [PMID: 31255282]
  • Kwang-Youn Kim, Kwang-Il Park, Seul Gi Lee, Su Youn Baek, Eun Hye Lee, Sang Chan Kim, Sang-Hun Kim, Sul-Gi Park, Sun-Nyoung Yu, Tae Woo Oh, Joung-Hee Kim, Keuk-Jun Kim, Soon-Cheol Ahn, Young Woo Kim. Deoxypodophyllotoxin in Anthriscus sylvestris alleviates fat accumulation in the liver via AMP-activated protein kinase, impeding SREBP-1c signal. Chemico-biological interactions. 2018 Oct; 294(?):151-157. doi: 10.1016/j.cbi.2018.08.025. [PMID: 30148990]
  • Liliana Lalaleo, Pilar Testillano, Maria-Carmen Risueño, Rosa M Cusidó, Javier Palazon, Ruben Alcazar, Mercedes Bonfill. Effect of in vitro morphogenesis on the production of podophyllotoxin derivatives in callus cultures of Linum album. Journal of plant physiology. 2018 Sep; 228(?):47-58. doi: 10.1016/j.jplph.2018.05.007. [PMID: 29852334]
  • Ying-Lan Yu, Ya-Nan Li, Yong Zhang, Ru-Ning Sun, Jia-Sheng Tu, Yan Shen. Optimization and characterization of deoxypodophyllotoxin loaded mPEG-PDLLA micelles by central composite design with response surface methodology. Chinese journal of natural medicines. 2018 Jun; 16(6):471-480. doi: 10.1016/s1875-5364(18)30081-5. [PMID: 30047469]
  • Yang Chen, Kaijing Zhao, Fei Liu, Ying Li, Zeyu Zhong, Shijin Hong, Xiaodong Liu, Li Liu. Predicting Antitumor Effect of Deoxypodophyllotoxin in NCI-H460 Tumor-Bearing Mice on the Basis of In Vitro Pharmacodynamics and a Physiologically Based Pharmacokinetic-Pharmacodynamic Model. Drug metabolism and disposition: the biological fate of chemicals. 2018 06; 46(6):897-907. doi: 10.1124/dmd.117.079830. [PMID: 29618575]
  • Christel L C Seegers, Pieter G Tepper, Rita Setroikromo, Wim J Quax. Cytotoxic Deoxypodophyllotoxin Can Be Extracted in High Purity from Anthriscus sylvestris Roots by Supercritical Carbon Dioxide. Planta medica. 2018 May; 84(8):544-550. doi: 10.1055/s-0043-123938. [PMID: 29253908]
  • Xiaojie Zang, Guangji Wang, Qingyun Cai, Xiao Zheng, Jingwei Zhang, Qianying Chen, Baojin Wu, Xiong Zhu, Haiping Hao, Fang Zhou. A Promising Microtubule Inhibitor Deoxypodophyllotoxin Exhibits Better Efficacy to Multidrug-Resistant Breast Cancer than Paclitaxel via Avoiding Efflux Transport. Drug metabolism and disposition: the biological fate of chemicals. 2018 05; 46(5):542-551. doi: 10.1124/dmd.117.079442. [PMID: 29523600]
  • Joël Doussot, Véronique Mathieu, Cyril Colas, Roland Molinié, Cyrielle Corbin, Josiane Montguillon, Laeticia Moreno Y Banuls, Sullivan Renouard, Frédéric Lamblin, Patricia Dupré, Benoit Maunit, Robert Kiss, Christophe Hano, Eric Lainé. Investigation of the Lignan Content in Extracts from Linum, Callitris and Juniperus Species in Relation to Their In Vitro Antiproliferative Activities. Planta medica. 2017 Apr; 83(6):574-581. doi: 10.1055/s-0042-118650. [PMID: 27776375]
  • Wei Zhao, Chen Zhou, Ze-Yuan Guan, Ping Yin, Fusheng Chen, Ya-Jie Tang. Structural Insights into the Inhibition of Tubulin by the Antitumor Agent 4β-(1,2,4-triazol-3-ylthio)-4-deoxypodophyllotoxin. ACS chemical biology. 2017 03; 12(3):746-752. doi: 10.1021/acschembio.6b00842. [PMID: 28035796]
  • Yutong Wang, Liping Huang, Yan Shen, Lidan Tang, Runing Sun, Di Shi, Thomas J Webster, Jiasheng Tu, Chunmeng Sun. Electrostatic interactions between polyglutamic acid and polylysine yields stable polyion complex micelles for deoxypodophyllotoxin delivery. International journal of nanomedicine. 2017; 12(?):7963-7977. doi: 10.2147/ijn.s140573. [PMID: 29133981]
  • Trong D Tran, Ngoc B Pham, Ron Booth, Paul I Forster, Ronald J Quinn. Lignans from the Australian Endemic Plant Austrobaileya scandens. Journal of natural products. 2016 06; 79(6):1514-23. doi: 10.1021/acs.jnatprod.5b00988. [PMID: 27214307]
  • Alina Ghinet, Iuliana-Monica Moise, Benoît Rigo, Germain Homerin, Amaury Farce, Joëlle Dubois, Elena Bîcu. Studies on phenothiazines: New microtubule-interacting compounds with phenothiazine A-ring as potent antineoplastic agents. Bioorganic & medicinal chemistry. 2016 05; 24(10):2307-17. doi: 10.1016/j.bmc.2016.04.001. [PMID: 27073050]
  • George R Pettit, Justin D Searcy, Rui Tan, Gordon M Cragg, Noeleen Melody, John C Knight, Jean-Charles Chapuis. Antineoplastic Agents. 585. Isolation of Bridelia ferruginea Anticancer Podophyllotoxins and Synthesis of 4-Aza-podophyllotoxin Structural Modifications. Journal of natural products. 2016 Mar; 79(3):507-18. doi: 10.1021/acs.jnatprod.5b00873. [PMID: 26938998]
  • Xiong Zhu, Junjie Fu, Yan Tang, Yuan Gao, Shijin Zhang, Qinglong Guo. Design and synthesis of novel 4'-demethyl-4-deoxypodophyllotoxin derivatives as potential anticancer agents. Bioorganic & medicinal chemistry letters. 2016 Feb; 26(4):1360-4. doi: 10.1016/j.bmcl.2015.06.089. [PMID: 26804229]
  • Ling Hui, Chunyan Sang, Donghong Wang, Xiaohui Wang, Meiliang Wang, Qinghua Jia, Mingren Ma, Shiwu Chen. Newly synthesized podophyllotoxin derivative, LJ12, induces apoptosis and mitotic catastrophe in non-small cell lung cancer cells in vitro. Molecular medicine reports. 2016 Jan; 13(1):339-46. doi: 10.3892/mmr.2015.4561. [PMID: 26573436]
  • Yurong Wang, Bin Wang, Mounia Guerram, Li Sun, Wei Shi, Chongchong Tian, Xiong Zhu, Zhenzhou Jiang, Luyong Zhang. Deoxypodophyllotoxin suppresses tumor vasculature in HUVECs by promoting cytoskeleton remodeling through LKB1-AMPK dependent Rho A activatio. Oncotarget. 2015 Oct; 6(30):29497-512. doi: 10.18632/oncotarget.4985. [PMID: 26470595]
  • Luyen Huynh Cong, Rebecca Dauwe, Michelle Lequart, Sophie Vinchon, Sullivan Renouard, Ophélie Fliniaux, Cyril Colas, Cyrielle Corbin, Joël Doussot, Christophe Hano, Frédéric Lamblin, Roland Molinié, Serge Pilard, Nathalie Jullian, Michèle Boitel, Eric Gontier, François Mesnard, Jean-Claude Laberche. Kinetics of glucosylated and non-glucosylated aryltetralin lignans in Linum hairy root cultures. Phytochemistry. 2015 Jul; 115(?):70-8. doi: 10.1016/j.phytochem.2015.01.001. [PMID: 25698360]
  • Marek Och, Anna Och, Łukasz Cieśla, Tomasz Kubrak, Łukasz Pecio, Anna Stochmal, Janusz Kocki, Anna Bogucka-Kocka. Study of cytotoxic activity, podophyllotoxin, and deoxypodophyllotoxin content in selected Juniperus species cultivated in Poland. Pharmaceutical biology. 2015 Jun; 53(6):831-7. doi: 10.3109/13880209.2014.943246. [PMID: 25720974]
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