3',4'-Dihydroxyacetophenone (BioDeep_00000396355)
Secondary id: BioDeep_00000008247
human metabolite PANOMIX_OTCML-2023 Endogenous natural product
代谢物信息卡片
化学式: C8H8O3 (152.0473)
中文名称: 3,4-二羟基苯乙酮, 3'，4'-二羟基苯乙酮
谱图信息:
最多检出来源 Homo sapiens(otcml) 3.81%
分子结构信息
SMILES: c1cc(c(cc1C(=O)C)O)O
InChI: InChI=1S/C8H8O3/c1-5(9)6-2-3-7(10)8(11)4-6/h2-4,10-11H,1H3
描述信息
3,4-Dihydroxyacetophenone is found in coffee and coffee products. 3,4-Dihydroxyacetophenone is extracted from coffee residues. Potential component of FEMA 3662. 3,4-Dihydroxyacetophenone is a mixture of dihydroxyacetophenone isomers is used in food flavourin
3,4-dihydroxyacetophenone is a member of acetophenones. It has a role as a metabolite.
3,4-Dihydroxyacetophenone is a natural product found in Vincetoxicum atratum, Picea obovata, and other organisms with data available.
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
3',4'-Dihydroxyacetophenone (3,4-DHAP), isolated from Picea Schrenkiana Needles exhibits a strong suppressive action against tyrosinase activity, with an IC50 of 10 μM. 3',4'-Dihydroxyacetophenone (3,4-DHAP) is a vasoactive agent and antioxidant[1][2].
3',4'-Dihydroxyacetophenone (3,4-DHAP), isolated from Picea Schrenkiana Needles exhibits a strong suppressive action against tyrosinase activity, with an IC50 of 10 μM. 3',4'-Dihydroxyacetophenone (3,4-DHAP) is a vasoactive agent and antioxidant[1][2].
同义名列表
33 个代谢物同义名
3 inverted exclamation mark ,4 inverted exclamation mark -Dihydroxyacetophenone; 3-METHYL-4-OXO-3,4-DIHYDRO-PHTHALAZINE-1-CARBOXYLICACIDHYDRAZIDE; 1-(3,4-dihydroxyphenyl)ethanone;3,4-Dihydroxyacetophenone; 1-(3,4-Dihydroxyphenyl)ethanone, 9CI; 1-[3,4-bis(oxidanyl)phenyl]ethanone; 1-(3,4-DIHYDROXYPHENYL)-1-ETHANONE; Ethanone, 1-(3,4-dihydroxyphenyl)-; 1-(3,4-dihydroxyphenyl)ethan-1-one; 1-(3,4-Dihydroxyphenyl)ethanone #; Acetopyrocatechol 4-Acetocatechol; 1-(3,4-Dihydroxyphenyl)-Ethanone; 1-(3,4-Dihydroxyphenyl)ethanone; Acetophenone, 3,4-dihydroxy-; Dihydroxyacetophenone; 98\\%; 3’,4’-Dihydroxyacetophenone; Acetophenone-3,4-dihydroxy; 3,4-Dihydroxyacetophenone; 3,4-dihydroxyacetophenone; 4-ACETYL-1,2-BENZENEDIOL; 4-Acetylpyrocatechol; 4-Acetopyrocatechol; Acetylpyrocatechol; Acetopyrocatechol; 4-acetylcatechol; 4-Acetocatechol; UNII-07OQ35LVBK; qingxintong; 07OQ35LVBK; HFO; 3,4-DHAP; 3',4'-Dihydroxyacetophenone; 3',4'-Dihydroxyacetophenone; 3',4'-Dihydroxyacetophenone
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:19868
- ChEBI: CHEBI:69446
- KEGG: C10675
- PubChem: 14530
- HMDB: HMDB0029661
- ChEMBL: CHEMBL243161
- MeSH: 3,4-dihydroxyacetophenone
- ChemIDplus: 0001197097
- KNApSAcK: C00002693
- foodb: FDB000835
- chemspider: 13873
- CAS: 1197-09-7
- medchemexpress: HY-N1775
- PubChem: 12858
- PDB-CCD: HFO
- 3DMET: B04050
- NIKKAJI: J7.452G
- LOTUS: LTS0252444
- KNApSAcK: 19868
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
32 个相关的物种来源信息
- 3319 - Abies: LTS0252444
- 342581 - Abies spectabilis: 10.1248/CPB.58.1646
- 342581 - Abies spectabilis: LTS0252444
- 4056 - Apocynaceae: LTS0252444
- 4890 - Ascomycota: LTS0252444
- 5455 - Colletotrichum: LTS0252444
- 474922 - Colletotrichum gloeosporioides: 10.1016/J.BMCL.2006.08.071
- 474922 - Colletotrichum gloeosporioides: LTS0252444
- 2759 - Eukaryota: LTS0252444
- 4751 - Fungi: LTS0252444
- 681950 - Glomerellaceae: LTS0252444
- 9606 - Homo sapiens: -
- 3398 - Magnoliopsida: LTS0252444
- 474995 - Ophiocordyceps: LTS0252444
- 72228 - Ophiocordyceps sinensis: 10.1021/NP100902F
- 72228 - Ophiocordyceps sinensis: LTS0252444
- 474942 - Ophiocordycipitaceae: LTS0252444
- 3328 - Picea: LTS0252444
- 3330 - Picea glauca: 10.1016/S0031-9422(96)00388-3
- 3330 - Picea glauca: LTS0252444
- 331118 - Picea obovata: 10.1007/BF00570214
- 331118 - Picea obovata: LTS0252444
- 3318 - Pinaceae: LTS0252444
- 58019 - Pinopsida: LTS0252444
- 33090 - Plants: -
- 147550 - Sordariomycetes: LTS0252444
- 35493 - Streptophyta: LTS0252444
- 58023 - Tracheophyta: LTS0252444
- 63501 - Vincetoxicum: LTS0252444
- 157443 - Vincetoxicum atratum: 10.1021/NP000428B
- 157443 - Vincetoxicum atratum: LTS0252444
- 33090 - Viridiplantae: LTS0252444
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zongguang Hui, Xuewei Zhou, Rujiang Li. Effect of 3,4-dihydroxyacetophenone on endothelial dysfunction in obese rats.
Pharmaceutical biology.
2015 Aug; 53(8):1149-54. doi:
10.3109/13880209.2014.962060. [PMID: 25693637] - Caiyan Liu, Jie Sun, Feng Xue, Yanchun Yi, Aiqiang Han. Effect of 3,4-dihydroxyacetophenone on endothelial dysfunction in streptozotocin-induced rats with type 2 diabetes.
Journal of cardiovascular pharmacology.
2015 Jan; 65(1):22-7. doi:
10.1097/fjc.0000000000000158. [PMID: 25162436] - Daijuan Zhang, Jiangyue Liu, Lin Wang, Jianying Wang, Wentao Li, Baoxiang Zhuang, Jianping Hou, Tongmei Liu. Effects of 3,4-dihydroxyacetophenone on the hypercholesterolemia-induced atherosclerotic rabbits.
Biological & pharmaceutical bulletin.
2013; 36(5):733-40. doi:
10.1248/bpb.b12-00710. [PMID: 23412669] - Xiao Ruan, Zhao-Hui Li, Qiang Wang, Cun-De Pan, De-An Jiang, G Geoff Wang. Autotoxicity and allelopathy of 3,4-dihydroxyacetophenone isolated from Picea schrenkiana needles.
Molecules (Basel, Switzerland).
2011 Oct; 16(10):8874-93. doi:
10.3390/molecules16108874. [PMID: 22024957] - Liya Li, Navindra P Seeram. Further investigation into maple syrup yields 3 new lignans, a new phenylpropanoid, and 26 other phytochemicals.
Journal of agricultural and food chemistry.
2011 Jul; 59(14):7708-16. doi:
10.1021/jf2011613. [PMID: 21675726] - Yi-Bin Zhao, Yue-Mao Shen, Hong-Ping He, Quan-Zhang Mu, Xiao-Jiang Hao. Antifungal agent and other constituents from Cynanchum otophyllum.
Natural product research.
2007 Mar; 21(3):203-10. doi:
10.1080/14786410601130364. [PMID: 17365709] - Xue-ya Lu, Wei-chang Chen. Effect of 3, 4-dihydroxyacetophenone on Na+, K+ -ATPase activity of injured mitochondria and the oxygen consumption of brain cells of rat.
Yao xue xue bao = Acta pharmaceutica Sinica.
2005 Jan; 40(1):13-6. doi:
. [PMID: 15881319] - Shizuka Saito, Jun Kawabata. Synergistic effects of thiols and amines on antiradical efficiency of protocatechuic acid.
Journal of agricultural and food chemistry.
2004 Dec; 52(26):8163-8. doi:
10.1021/jf048970j. [PMID: 15612812] - S H Day, J P Wang, S J Won, C N Lin. Bioactive constituents of the roots of Cynanchum atratum.
Journal of natural products.
2001 May; 64(5):608-11. doi:
10.1021/np000428b. [PMID: 11374953] - Y Huang, D Ye, T Ma. [The effects of 3,4-dihydroxyacetophynone on the activity of nitric oxide synthetase in placental vascular endothelial cells and smooth muscle cells and on the level of endothelin-1 in plasma from pregnancy-induced hypertension patients].
Zhonghua fu chan ke za zhi.
1996 Nov; 31(11):667-9. doi:
. [PMID: 9387527] - F Qiao, L Wen, J Xu. [Uteroplacental blood flow monitoring by color Doppler flow imaging in pregnancy induced hypertension].
Zhonghua fu chan ke za zhi.
1995 Jun; 30(6):337-9. doi:
. [PMID: 7555365] - C Lin, Z Zhang, Y Xu. [Therapeutical mechanism of 3,4 dihydroxyacetophenone in treating chronic obstructive pulmonary disease].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases.
1995 Apr; 18(2):97-8, 128. doi:
. [PMID: 7553961] - C L Lin, Z X Zhang, Y J Xu. [Effects of dihydroxyacetophenone on pulmonary hemodynamics and plasma ANP as well as cAMP/cGMP level in patients with chronic obstructive pulmonary disease].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
1995 Mar; 15(3):131-3. doi:
NULL. [PMID: 7647523] - D H Peng, L Shi. [Effect of 3,4-dihydroxyacetophenone on phospholipid components of platelet membrane in aged rats].
Yao xue xue bao = Acta pharmaceutica Sinica.
1995; 30(5):343-6. doi:
". [PMID: 7660804] - Y P Sun. [Effect of 3,4-dihydroxyacetophenone on platelet aggregation in normal pregnancy and pregnancy induced hypertension].
Zhonghua fu chan ke za zhi.
1992 Jan; 27(1):9-11, 57. doi:
. [PMID: 1505279] - D S Yang, W Xi-rui, M Ting-yuan. Effects of 3,4-dihydroxyacetophenone on the biosynthesis of TXA2 and PGI2 in human placental villus and umbilical artery segments in vitro.
Prostaglandins.
1989 Oct; 38(4):497-504. doi:
10.1016/0090-6980(89)90131-7. [PMID: 2510216] - Q B Zhang, K R Gu. [Dihydroxyacetophenone and dihydroxyphenyllactic acid increased blood flow in rat liver microcirculation].
Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine.
1987 Oct; 7(10):608-9, 582. doi:
". [PMID: 3447762] - Y Z Liu. [Effect of Qingxintong on exercise ECG and cardiac function in patients with angina pectoris].
Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine.
1984 May; 4(5):262-4. doi:
. [PMID: 6236891]
