Baicalin (BioDeep_00000003537)

natural product human metabolite PANOMIX_OTCML-2023

代谢物信息卡片

(2S,3S,4S,5R,6R)-6-[(5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid

化学式: C21H18O11 (446.0849078)
中文名称: 黄芩苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1(c(c(c2c(c1)oc(cc2=O)c1ccccc1)O)O)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)C(=O)O)O)O)O
InChI: InChI=1S/C21H18O11/c22-9-6-10(8-4-2-1-3-5-8)30-11-7-12(14(23)15(24)13(9)11)31-21-18(27)16(25)17(26)19(32-21)20(28)29/h1-7,16-19,21,23-27H,(H,28,29)/t16-,17-,18+,19-,21+/m0/s1

描述信息

Baicalin is a flavone, a type of flavonoid. It is found in several species in the genus Scutellaria, including Scutellaria lateriflora (blue skullcap). There are 10 mg/g baicalin in Scutellaria galericulata (common skullcap) leaves. Baicalin is the glucuronide of baicalein. It is a component of Chinese medicinal herb Huang-chin (Scutellaria baicalensis) and one of the chemical ingredients of Sho-Saiko-To, an herbal supplement.
Acquisition and generation of the data is financially supported in part by CREST/JST.
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D000890 - Anti-Infective Agents
D018501 - Antirheumatic Agents
D004791 - Enzyme Inhibitors
Baicalin, as a flavonoid glycoside, is an allosteric carnitine palmityl transferase 1 (CPT1) activator. Baicalin reduces the expression of NF-κB[1][2][3].
Baicalin, as a flavonoid glycoside, is an allosteric carnitine palmityl transferase 1 (CPT1) activator. Baicalin reduces the expression of NF-κB[1][2][3].

同义名列表

13 个代谢物同义名

(2S,3S,4S,5R,6R)-6-[(5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid; (2S,3S,4S,5R,6R)-6-[(5,6-dihydroxy-4-oxo-2-phenylchromen-7-yl)oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid; (2S,3S,4S,5R,6R)-6-[(5,6-Dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy]-3,4,5-trihydroxyoxane-2-carboxylate; 5,6-dihydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl beta-D-glucopyranosiduronic acid; 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid; 5,6,7-trihydroxyflavone 7-O-beta-D-glucuronide; 7-D-glucuronic acid-5,6-dihydroxyflavone; Baicalein 7-O-glucuronide; Baicalein-7-O-glucuronide; Baicalein 7-glucuronide; Oprea1_484812; Baicalin; Baicalein 7-O-β-D-glucuronide

数据库引用编号

44 个数据库交叉引用编号

ChEBI: CHEBI:2981
KEGG: C10025
PubChem: 13654833
PubChem: 3807559
PubChem: 64982
HMDB: HMDB0041832
Metlin: METLIN49507
ChEMBL: CHEMBL485818
Wikipedia: Baicalin
LipidMAPS: LMPK12111081
MetaCyc: CPD-12725
KNApSAcK: C00001024
chemspider: 16498738
CAS: 31564-28-0
CAS: 21967-41-9
MoNA: PS041505
MoNA: PS041510
MoNA: PR020033
MoNA: PR040077
MoNA: PS041502
MoNA: PS041511
MoNA: PS041508
MoNA: PS041504
MoNA: PR040076
MoNA: PR040080
MoNA: PR040074
MoNA: PS041503
MoNA: PS041507
MoNA: PS041501
MoNA: PR040079
MoNA: PS041506
MoNA: PR040073
MoNA: PS041509
MoNA: PR100652
MoNA: PR040078
MoNA: PR100237
MoNA: PR040075
PMhub: MS000009935
PubChem: 12211
PDB-CCD: 0XE
3DMET: B03469
NIKKAJI: J94.473D
RefMet: Baicalin
medchemexpress: HY-N0197

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

122 个相关的物种来源信息

2906878 Aria edulis: 10.1248/CPB.39.199
233893 Scutellaria lateriflora:
396367 Scutellaria barbata:
587679 Scutellaria scordifolia:
516072 Scutellaria rehderiana:
1052904 Scutellaria amoena:
512023 Scutellaria viscidula:
2182738 Scutellaria hypericifolia:
65409 Scutellaria baicalensis:
329779 Solanum incanum:
329779 Solanum incanum:
2291122 Eleutherococcus brachypus: 10.1248/CPB.59.135
2291122 Eleutherococcus brachypus: 10.1248/CPB.59.135
46147 Portulaca oleracea: 10.1002/PCA.2524
46147 Portulaca oleracea: 10.1002/PCA.2524
1986532 Scutellaria strigillosa: 10.1007/S11418-005-0023-1
1986532 Scutellaria strigillosa: 10.1007/S11418-005-0023-1
2200806 Scutellaria squarrosa: 10.1007/BF00599011
2200806 Scutellaria squarrosa: 10.1007/BF00599011
65409 Scutellaria baicalensis:
65409 Scutellaria baicalensis:
2858926 Scutellaria grossa: 10.1248/CPB.39.1051
2858926 Scutellaria grossa: 10.1248/CPB.39.1051
2858894 Scutellaria comosa: 10.1007/BF01167595
2858894 Scutellaria comosa: 10.1007/BF01167595
53167 Scutellaria alpina: 10.1248/CPB.39.199
53167 Scutellaria alpina: 10.1248/CPB.39.199
392618 Cunila: 10.1007/S00299-018-2303-8
392618 Cunila: 10.1007/S00299-018-2303-8
2858946 Scutellaria prostrata: 10.1248/CPB.39.1047
2858946 Scutellaria prostrata: 10.1248/CPB.39.1047
2802346 Scutellaria scandens: 10.1248/CPB.36.2371
2802346 Scutellaria scandens: 10.1248/CPB.36.2371
1264565 Thalictrum baicalense:
1264565 Thalictrum baicalense:
396367 Scutellaria barbata:
396367 Scutellaria barbata:
1052904 Scutellaria amoena:
1052904 Scutellaria amoena:
4139 Scutellaria:
4139 Scutellaria:
2721170 Scutellaria przewalskii: 10.1007/BF00569021
2721170 Scutellaria przewalskii: 10.1007/BF00569021
53168 Scutellaria altissima: 10.1007/BF00566807
53168 Scutellaria altissima: 10.1007/BF00566807
53169 Scutellaria galericulata:
53169 Scutellaria galericulata:
72917 Erigeron canadensis: 10.1016/J.CCLET.2010.02.022
72917 Erigeron canadensis: 10.1016/J.CCLET.2010.02.022
72917 Conyza canadensis: 10.1016/J.CCLET.2010.02.022
72917 Conyza canadensis: 10.1016/J.CCLET.2010.02.022
83951 Oroxylum indicum:
83951 Oroxylum indicum:
53170 Scutellaria orientalis: 10.1007/BF00567878
53170 Scutellaria orientalis: 10.1007/BF00567878
233893 Scutellaria lateriflora: 10.1021/NP0205102
233893 Scutellaria lateriflora: 10.1021/NP0205102
1650721 Rubia yunnanensis: 10.1248/CPB.50.276
1650721 Rubia yunnanensis: 10.1248/CPB.50.276
2906878 Aria edulis: 10.1248/CPB.39.199
233893 Scutellaria lateriflora:
396367 Scutellaria barbata:
587679 Scutellaria scordifolia:
516072 Scutellaria rehderiana:
1052904 Scutellaria amoena:
512023 Scutellaria viscidula:
2182738 Scutellaria hypericifolia:
65409 Scutellaria baicalensis:
329779 Solanum incanum:
329779 Solanum incanum:
2291122 Eleutherococcus brachypus: 10.1248/CPB.59.135
2291122 Eleutherococcus brachypus: 10.1248/CPB.59.135
46147 Portulaca oleracea: 10.1002/PCA.2524
46147 Portulaca oleracea: 10.1002/PCA.2524
1986532 Scutellaria strigillosa: 10.1007/S11418-005-0023-1
1986532 Scutellaria strigillosa: 10.1007/S11418-005-0023-1
2200806 Scutellaria squarrosa: 10.1007/BF00599011
2200806 Scutellaria squarrosa: 10.1007/BF00599011
65409 Scutellaria baicalensis:
65409 Scutellaria baicalensis:
2858926 Scutellaria grossa: 10.1248/CPB.39.1051
2858926 Scutellaria grossa: 10.1248/CPB.39.1051
2858894 Scutellaria comosa: 10.1007/BF01167595
2858894 Scutellaria comosa: 10.1007/BF01167595
53167 Scutellaria alpina: 10.1248/CPB.39.199
53167 Scutellaria alpina: 10.1248/CPB.39.199
392618 Cunila: 10.1007/S00299-018-2303-8
392618 Cunila: 10.1007/S00299-018-2303-8
2858946 Scutellaria prostrata: 10.1248/CPB.39.1047
2858946 Scutellaria prostrata: 10.1248/CPB.39.1047
2802346 Scutellaria scandens: 10.1248/CPB.36.2371
2802346 Scutellaria scandens: 10.1248/CPB.36.2371
1264565 Thalictrum baicalense:
1264565 Thalictrum baicalense:
396367 Scutellaria barbata:
396367 Scutellaria barbata:
1052904 Scutellaria amoena:
1052904 Scutellaria amoena:
4139 Scutellaria:
4139 Scutellaria:
2721170 Scutellaria przewalskii: 10.1007/BF00569021
2721170 Scutellaria przewalskii: 10.1007/BF00569021
53168 Scutellaria altissima: 10.1007/BF00566807
53168 Scutellaria altissima: 10.1007/BF00566807
53169 Scutellaria galericulata:
53169 Scutellaria galericulata:
72917 Erigeron canadensis: 10.1016/J.CCLET.2010.02.022
72917 Erigeron canadensis: 10.1016/J.CCLET.2010.02.022
72917 Conyza canadensis: 10.1016/J.CCLET.2010.02.022
72917 Conyza canadensis: 10.1016/J.CCLET.2010.02.022
83951 Oroxylum indicum:
83951 Oroxylum indicum:
53170 Scutellaria orientalis: 10.1007/BF00567878
53170 Scutellaria orientalis: 10.1007/BF00567878
233893 Scutellaria lateriflora: 10.1021/NP0205102
233893 Scutellaria lateriflora: 10.1021/NP0205102
1650721 Rubia yunnanensis: 10.1248/CPB.50.276
1650721 Rubia yunnanensis: 10.1248/CPB.50.276
9606 Homo sapiens: -
226208 Salvia miltiorrhiza Bge.: -
65409 Scutellaria baicalensis Georgi: -
33090 Plants: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Yuan Gao, Yang-Yang Sun, Dong Bai, Xiao-Xia Wu. Mechanism of the components compatibility of Scutellariae Radix and Coptidis Rhizoma on mice with hyperlipidemia by regulating the Cyp4a family. Journal of ethnopharmacology. 2024 Sep; 331(?):118263. doi: 10.1016/j.jep.2024.118263. [PMID: 38677575]
Yanqin Luo, Bo Lin, Peng Yu, Di Zhang, Yingfan Hu, Xianli Meng, Li Xiang. Scutellaria baicalensis water decoction ameliorates lower respiratory tract infection by modulating respiratory microbiota. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155706. doi: 10.1016/j.phymed.2024.155706. [PMID: 38723528]
Kaili Liu, Ying Zhou, Xianrui Song, Jiahan Zeng, Zhuqi Wang, Ziqing Wang, Honglei Zhang, Jiaxing Xu, Wenting Li, Zixuan Gong, Min Wang, Baolin Liu, Na Xiao, Kang Liu. Baicalin attenuates neuronal damage associated with SDH activation and PDK2-PDH axis dysfunction in early reperfusion. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155570. doi: 10.1016/j.phymed.2024.155570. [PMID: 38579645]
Shunfen Zhang, Shanlong Tang, Zhengqun Liu, Huiyuan Lv, Xueying Cai, Ruqing Zhong, Liang Chen, Hongfu Zhang. Baicalin restore intestinal damage after early-life antibiotic therapy: the role of the MAPK signaling pathway. Pharmacological research. 2024 Jun; 204(?):107194. doi: 10.1016/j.phrs.2024.107194. [PMID: 38663526]
Lihua Shao, Li Zhu, Rong Su, Chunting Yang, Xiaqing Gao, Yan Xu, Hongwei Wang, Chenglong Guo, Hailong Li. Baicalin enhances the chemotherapy sensitivity of oxaliplatin-resistant gastric cancer cells by activating p53-mediated ferroptosis. Scientific reports. 2024 05; 14(1):10745. doi: 10.1038/s41598-024-60920-y. [PMID: 38730240]
Juyeong Cho, Eun-Bin Hong, Young-Sik Kim, Jungbin Song, Yeon Ha Ju, Hyunjin Kim, Hyowon Lee, Hocheol Kim, Min-Ho Nam. Baicalin and baicalein from Scutellaria baicalensis Georgi alleviate aberrant neuronal suppression mediated by GABA from reactive astrocytes. CNS neuroscience & therapeutics. 2024 05; 30(5):e14740. doi: 10.1111/cns.14740. [PMID: 38715318]
Yanfang Zheng, Chenxiang Wang, Wenjing Liu, Jiaying Chen, Yibin Sun, Dennis Chang, Huan Wang, Wen Xu, Jin-Jian Lu, Xian Zhou, Mingqing Huang. Upregulation of Nrf2 signaling: A key molecular mechanism of Baicalin's neuroprotective action against diabetes-induced cognitive impairment. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 May; 174(?):116579. doi: 10.1016/j.biopha.2024.116579. [PMID: 38631145]
Ying Cheng, Mengchao Yan, Shuyu He, Yi Xie, Lihui Wei, Bihan Xuan, Zucheng Shang, Meizhu Wu, Huifang Zheng, Youqin Chen, Meng Yuan, Jun Peng, Aling Shen. Baicalin alleviates angiotensin II-induced cardiomyocyte apoptosis and autophagy and modulates the AMPK/mTOR pathway. Journal of cellular and molecular medicine. 2024 May; 28(9):e18321. doi: 10.1111/jcmm.18321. [PMID: 38712979]
Shuangxiu Wan, Linzheng Wang, Zhili Hao, Lin Zhu, Xiaoxia Mao, Hongquan Li, Panpan Sun, Wei Yin, Kuohai Fan, Hailong Zhang, Beibei Li, Wansen Nie, Zongjie Li, Na Sun. Baicalin ameliorates the gut barrier function and intestinal microbiota of broiler chickens. Acta biochimica et biophysica Sinica. 2024 04; 56(4):634-644. doi: 10.3724/abbs.2024029. [PMID: 38511207]
Lin Zhang, Ceyu Miao, Zhixuan Wang, Xiulu Guan, Yechao Ma, Jingyu Song, Shiyuan Shen, Hongru Song, Mingqian Li, Cuizhe Liu. Preparation and characterisation of baicalin magnesium and its protective effect in ulcerative colitis via gut microbiota-bile acid axis modulation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Apr; 126(?):155416. doi: 10.1016/j.phymed.2024.155416. [PMID: 38394726]
Yucheng Yan, Safdar Ali Amur, Hong Liu, Ruoyao Shen, Huaiqing Sun, Yunlin Pei, Chaowan Guo, Hao Liang. Endogenous crude Scutellaria baicalensis polysaccharide robustly enhances one-pot extraction and deglycosylation of baicalin. International journal of biological macromolecules. 2024 Apr; 263(Pt 1):130349. doi: 10.1016/j.ijbiomac.2024.130349. [PMID: 38387634]
Wanting Fu, Ziyuan Liu, Yingzhou Wang, Xindi Li, Xiang Yu, Yang Li, Zejun Yu, Yinsheng Qiu, Zhinan Mei, Lingyun Xu. Baicalin inhibits monosodium urate crystal-induced pyroptosis in renal tubular epithelial cell line through Panx-1/P2X7 pathways: Molecular docking, molecular dynamics, and in vitro experiments. Chemical biology & drug design. 2024 Apr; 103(4):e14522. doi: 10.1111/cbdd.14522. [PMID: 38580458]
Xiaoxuan Zhao, Ying Zhao, Qujia Yang, Jing Ma, Yang Zhao, Suxia Wang, Yuepeng Jiang, Qin Zhang. Baicalin ameliorates deficient decidualization in URSA by regulating mitochondrial fission induced necroptosis. Biochimica et biophysica acta. Molecular cell research. 2024 Mar; 1871(3):119675. doi: 10.1016/j.bbamcr.2024.119675. [PMID: 38242329]
Lina Wan, Yuchen Li, Wenhao Liao, Lizhen Lei, Maoyuan Zhao, Jinhao Zeng, Ziyi Zhao, Jianyuan Tang. Synergistic inhibition effects of andrographolide and baicalin on coronavirus mechanisms by downregulation of ACE2 protein level. Scientific reports. 2024 02; 14(1):4287. doi: 10.1038/s41598-024-54722-5. [PMID: 38383655]
Haipeng Feng, Jingyan Zhang, Xuezhi Wang, Zhiting Guo, Lei Wang, Kang Zhang, Jianxi Li. Baicalin Protects Broilers against Avian Coronavirus Infection via Regulating Respiratory Tract Microbiota and Amino Acid Metabolism. International journal of molecular sciences. 2024 Feb; 25(4):. doi: 10.3390/ijms25042109. [PMID: 38396786]
Lingchao Miao, Xutao Zhang, Haolin Zhang, Meng Sam Cheong, Xiaojia Chen, Mohamed A Farag, Wai San Cheang, Jianbo Xiao. Baicalin ameliorates insulin resistance and regulates hepatic glucose metabolism via activating insulin signaling pathway in obese pre-diabetic mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Feb; 124(?):155296. doi: 10.1016/j.phymed.2023.155296. [PMID: 38176276]
Jun Chen, Chuhua Lin, Xiurong Huang, Wei Bian. Baicalin enhances proliferation and reduces inflammatory-oxidative stress effect in H2O2-induced granulosa cells apoptosis via USP48 protein regulation. BMC complementary medicine and therapies. 2024 Jan; 24(1):42. doi: 10.1186/s12906-024-04346-z. [PMID: 38245760]
Qirong Lu, Nan Wang, Defeng Wen, Pu Guo, Yu Liu, Shulin Fu, Chun Ye, Zhongyuan Wu, Yinsheng Qiu. Baicalin attenuates lipopolysaccharide-induced intestinal inflammatory injury via suppressing PARP1-mediated NF-κB and NLRP3 signalling pathway. Toxicon : official journal of the International Society on Toxinology. 2024 Jan; 239(?):107612. doi: 10.1016/j.toxicon.2024.107612. [PMID: 38211803]
Jiahua Huang, Xinyue Zhang, Xueping Yang, Qingyun Yv, Fanlong Ye, Sheng Chen, Ying Cui, Linting Gu, Min Zhu, Wenwei Li. Baicalin exerts neuroprotective actions by regulating the Nrf2-NLRP3 axis in toxin-induced models of Parkinson's disease. Chemico-biological interactions. 2024 Jan; 387(?):110820. doi: 10.1016/j.cbi.2023.110820. [PMID: 38016618]
Jiuxiang Liu, Hao Zhou, Jiangqi Chen, Qiang Zuo, Feng Liu. Baicalin inhibits IL-1β-induced ferroptosis in human osteoarthritis chondrocytes by activating Nrf-2 signaling pathway. Journal of orthopaedic surgery and research. 2024 Jan; 19(1):23. doi: 10.1186/s13018-023-04483-0. [PMID: 38166985]
Ruolei Wang, Chunyan Wang, Lianheng Lu, Fuwen Yuan, Feng He. Baicalin and baicalein in modulating tumor microenvironment for cancer treatment: A comprehensive review with future perspectives. Pharmacological research. 2024 Jan; 199(?):107032. doi: 10.1016/j.phrs.2023.107032. [PMID: 38061594]
Zhang Yu, Liu Xiaojia, Zhao Wei, Zhang Jian, Wang Aiting, Wang Jing, Yang Lin, Cao Bangwei, Yan Dan. Baicalin circumvents anti-PD-1 resistance by regulating the gut microbiota metabolite short-chain fatty acids. Pharmacological research. 2024 Jan; 199(?):107033. doi: 10.1016/j.phrs.2023.107033. [PMID: 38061593]
Hongtu Hu, Weiwei Li, Yiqun Hao, Zhuan Peng, Zhengping Zou, Wei Liang. Baicalin ameliorates renal fibrosis by upregulating CPT1α-mediated fatty acid oxidation in diabetic kidney disease. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 122(?):155162. doi: 10.1016/j.phymed.2023.155162. [PMID: 37922789]
Li Wang, Shenyi Huang, Xiaolun Liang, Junliang Zhou, Yifan Han, Jiangshan He, Danping Xu. Immuno-modulatory role of baicalin in atherosclerosis prevention and treatment: current scenario and future directions. Frontiers in immunology. 2024; 15(?):1377470. doi: 10.3389/fimmu.2024.1377470. [PMID: 38698839]
Tomasz Szkudelski, Katarzyna Szkudelska. The Anti-Diabetic Potential of Baicalin: Evidence from Rodent Studies. International journal of molecular sciences. 2023 Dec; 25(1):. doi: 10.3390/ijms25010431. [PMID: 38203600]
Haipeng Feng, Jingyan Zhang, Kang Zhang, Xuezhi Wang, Zhiting Guo, Lei Wang, Jianxi Li. Synergistic anti-infectious bronchitis virus activity of Phillygenin combined Baicalin by modulating respiratory microbiota and improving metabolic disorders. Poultry science. 2023 Dec; 103(2):103371. doi: 10.1016/j.psj.2023.103371. [PMID: 38150830]
Han-Young Kim, Jung-Hoon Kim. Chemical Characterization of the Precipitate Found in and Its Effect on Drug Release of the Scutellaria baicalensis -Coptis chinensis Extract. Chemistry & biodiversity. 2023 Nov; ?(?):e202301461. doi: 10.1002/cbdv.202301461. [PMID: 37961037]
Xiao-Yu Zheng, Ye-Hao Zhang, Wen-Ting Song, Guang-Yu Liu, Zhao Ding, Jian-Xun Liu. [Baicalin improves inflammatory response of human microglia by regulating cAMP-PKA-NF-κB/CREB pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Nov; 48(21):5863-5870. doi: 10.19540/j.cnki.cjcmm.20230614.704. [PMID: 38114182]
Gyeong Han Jeong, Hanui Lee, Hong-Ki Lee, Hyo Jin Choi, Byung Yeoup Chung, Hyoung-Woo Bai. Inhibitory effect of γ-ray-modified hydroxymethylated baicalins on NO production. Bioorganic & medicinal chemistry letters. 2023 Sep; 96(?):129491. doi: 10.1016/j.bmcl.2023.129491. [PMID: 37778427]
Qichao Hu, Shuyu Hou, Baoyi Xiong, Yueqiang Wen, Jundong Wang, Jinhao Zeng, Xiao Ma, Fang Wang. Therapeutic Effects of Baicalin on Diseases Related to Gut-Brain Axis Dysfunctions. Molecules (Basel, Switzerland). 2023 Sep; 28(18):. doi: 10.3390/molecules28186501. [PMID: 37764277]
T Szkudelski, K Konieczna, K Szkudelska. Regulatory effects of baicalin, a flavonoid compound, on adipocyte metabolism. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2023 Aug; 74(4):. doi: 10.26402/jpp.2023.4.05. [PMID: 37865958]
Yan-Rong Gong, Cheng Zhang, Xing Xiang, Zhi-Bo Wang, Yu-Qing Wang, Yong-Hua Su, Hui-Qing Zhang. Baicalin, silver titanate, Bletilla striata polysaccharide and carboxymethyl chitosan in a porous sponge dressing for burn wound healing. Journal of integrative medicine. 2023 Jul; ?(?):. doi: 10.1016/j.joim.2023.07.002. [PMID: 37544834]
Anastasia Dmitrieva, Oksana Kozlova, Victor Atuchin, Irina Milentieva, Anna Vesnina, Svetlana Ivanova, Lyudmila Asyakina, Alexander Prosekov. Study of the Effect of Baicalin from Scutellaria baicalensis on the Gastrointestinal Tract Normoflora and Helicobacter pylori. International journal of molecular sciences. 2023 Jul; 24(15):. doi: 10.3390/ijms241511906. [PMID: 37569279]
Dongli Qi, Bei Jia, Hui Peng, Jiachen He, Jiaxin Pi, Pan Guo, Ying Zhang, Xiuping Deng, Jiawei Li, Zhidong Liu. Baicalin/ambroxol hydrochloride combined dry powder inhalation formulation targeting lung delivery for treatment of idiopathic pulmonary fibrosis: Fabrication, characterization, pharmacokinetics, and pharmacodynamics. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2023 Jul; 188(?):243-253. doi: 10.1016/j.ejpb.2023.05.017. [PMID: 37224929]
Ming-Hui Wu, Kun Wu, Yuan-Bing Zhu, Da-Chuan Li, Huan Yang, Hong Zeng. Baicalin Antagonizes Prostate Cancer Stemness via Inhibiting Notch1/NF-κB Signaling Pathway. Chinese journal of integrative medicine. 2023 Jun; ?(?):. doi: 10.1007/s11655-023-3595-2. [PMID: 37357241]
Xiaoyuan Ning, Dongping Luo, Yong Chen, Yeqing Shao, Jiayun Xu. Baicalin Reduces Renal Inflammation in Mesangial Proliferative Glomerulonephritis through Activation of Nrf2/ARE and PI3K/AKT Pathways. Discovery medicine. 2023 06; 35(176):372-382. doi: 10.24976/discov.med.202335176.38. [PMID: 37272104]
Jialing Sun, Xuemei Yang, Haitao Sun, Shaohui Huang, Haiyan An, Wei Xu, Weicong Chen, Wenting Zhao, Chunyu He, Xiaodan Zhong, Tong Li, Yang Liu, Bin Wen, Qingfeng Du, Songqi He. Baicalin inhibits hepatocellular carcinoma cell growth and metastasis by suppressing ROCK1 signaling. Phytotherapy research : PTR. 2023 May; ?(?):. doi: 10.1002/ptr.7873. [PMID: 37246830]
Jiahua Liang, Ying Zhou, Xinyi Cheng, Jiaqi Chen, Huabin Cao, Xiaoquan Guo, Caiying Zhang, Yu Zhuang, Guoliang Hu. Baicalin Attenuates H2O2-Induced Oxidative Stress by Regulating the AMPK/Nrf2 Signaling Pathway in IPEC-J2 Cells. International journal of molecular sciences. 2023 May; 24(11):. doi: 10.3390/ijms24119435. [PMID: 37298392]
Rui-Jia Wen, Xin Dong, Hao-Wen Zhuang, Feng-Xiang Pang, Shou-Chang Ding, Nan Li, Yong-Xin Mai, Shu-Ting Zhou, Jun-Yan Wang, Jin-Fang Zhang. Baicalin induces ferroptosis in osteosarcomas through a novel Nrf2/xCT/GPX4 regulatory axis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 May; 116(?):154881. doi: 10.1016/j.phymed.2023.154881. [PMID: 37209607]
Zhenqiao Wei, Rui Gao, Zhen Sun, Wen Yang, Qi He, Chenhui Wang, Jingxiang Zhang, Xiaochang Zhang, Liang Guo, Shengqi Wang. Baicalin inhibits influenza A (H1N1)-induced pyroptosis of lung alveolar epithelial cells via caspase-3/GSDME pathway. Journal of medical virology. 2023 May; 95(5):e28790. doi: 10.1002/jmv.28790. [PMID: 37212338]
Aswad Khadilkar, Zoie L Bunch, Jessica Wagoner, Vandana Ravindran, Jessica M Oda, Warren S Vidar, Trevor N Clark, Preston K Manwill, Daniel A Todd, Sarah A Barr, Lauren K Olinger, Susan L Fink, Wendy K Strangman, Roger G Linington, John B MacMillan, Nadja B Cech, Stephen J Polyak. Modulation of in Vitro SARS-CoV-2 Infection by Stephania tetrandra and Its Alkaloid Constituents. Journal of natural products. 2023 Apr; 86(4):1061-1073. doi: 10.1021/acs.jnatprod.3c00159. [PMID: 37043739]
Xiu-Ying Li, Luan-Xia Shi, Ning-Ning Shi, Wei-Wei Chen, Xiu-Wu Qu, Qin-Qing Li, Xiu-Jun Duan, Xue-Tao Li, Qing-Shan Li. Multiple stimulus-response berberine plus baicalin micelles with particle size-charge-release triple variable properties for breast cancer therapy. Drug development and industrial pharmacy. 2023 Apr; ?(?):1-18. doi: 10.1080/03639045.2023.2195501. [PMID: 36971392]
Mengyuan Li, Yumeng Wang, Jing Xue, Qingqing Xu, Yuerong Zhang, Jie Liu, Hai Xu, Zhuo Guan, Chengyue Bian, Guangdong Zhang, Yan Yu. Baicalin can enhance odonto/osteogenic differentiation of inflammatory dental pulp stem cells by inhibiting the NF-κB and β-catenin/Wnt signaling pathways. Molecular biology reports. 2023 Apr; ?(?):. doi: 10.1007/s11033-023-08398-1. [PMID: 37009956]
Peichun Wang, Jiao Wu, Qiongsen Wang, Shaowei Zhuang, Jing Zhao, Ying Yu, Weidong Zhang, Yuejuan Zheng, Xuan Liu. Baicalin inhibited both the Furin/TGFβ1/Smad3/TSP-1 pathway in endothelial cells and the AKT/Ca2+/ROS pathway in platelets to ameliorate inflammatory coagulopathy. European journal of pharmacology. 2023 Mar; ?(?):175674. doi: 10.1016/j.ejphar.2023.175674. [PMID: 36963651]
Jiajie Jiang, Te-Chan Kao, Sihan Hu, Yubing Li, Weiyi Feng, Xiaochuan Guo, Jinhao Zeng, Xiao Ma. Protective role of baicalin in the dynamic progression of lung injury to idiopathic pulmonary fibrosis: A meta-analysis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Mar; 114(?):154777. doi: 10.1016/j.phymed.2023.154777. [PMID: 37018850]
Xiulu Guan, Shiyuan Shen, Jinxia Liu, Hongru Song, Jinhua Chang, Xiaoxia Mao, Jingyu Song, Lin Zhang, Cuizhe Liu. Protective effecs of baicalin magnesium on non-alcoholic steatohepatitis rats are based on inhibiting NLRP3/Caspase-1/IL-1β signaling pathway. BMC complementary medicine and therapies. 2023 Mar; 23(1):72. doi: 10.1186/s12906-023-03903-2. [PMID: 36879310]
Yi Cai, Shisheng Jiang, Chaoming Huang, Ao Shen, Xuan Zhang, Wanling Yang, Yichuan Xiao, Shuhan Gao, Rong Du, Guodong Zheng, Tingdong Yan, Chunpeng Craig Wan. Baicalin inhibits pressure overload-induced cardiac hypertrophy by regulating the SIRT3-dependent signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Mar; 114(?):154747. doi: 10.1016/j.phymed.2023.154747. [PMID: 36931095]
Bin Jia, Yaping Jiang, Yao Yao, Yingxing Xu, Yingzhen Wang, Tao Li. Baicalin attenuates dexamethasone-induced apoptosis of bone marrow mesenchymal stem cells by activating the hedgehog signaling pathway. Chinese medical journal. 2023 Feb; ?(?):. doi: 10.1097/cm9.0000000000002113. [PMID: 36804262]
Yanxia Gao, Jingbo Liu, Zhili Hao, Na Sun, Jianhua Guo, Xiaozhong Zheng, Panpan Sun, Wei Yin, Kuohai Fan, Hongquan Li. Baicalin ameliorates high fat diet-induced nonalcoholic fatty liver disease in mice via adenosine monophosphate-activated protein kinase-mediated regulation of SREBP1/Nrf2/NF-κB signaling pathways. Phytotherapy research : PTR. 2023 Feb; ?(?):. doi: 10.1002/ptr.7762. [PMID: 36752274]
Xiao-Die Cui, Jun-Kai Zhang, Ya-Wei Sun, Feng-Bin Yan, Jin-Feng Zhao, Dan-Dan He, Yu-Shan Pan, Li Yuan, Ya-Jun Zhai, Gong-Zheng Hu. Synergistic antibacterial activity of baicalin and EDTA in combination with colistin against colistin-resistant Salmonella. Poultry science. 2023 Feb; 102(2):102346. doi: 10.1016/j.psj.2022.102346. [PMID: 36493546]
Jingjing Tian, Xiaoyun He, Xinyue Lan, Xingxing Liang, Zhaobin Zhong, Longjiao Zhu, Keren Chen, Qiaoying Chang, Wentao Xu. One-Pot Controllable Assembly of a Baicalin-Condensed Aptamer Nanodrug for Synergistic Anti-Obesity. Small (Weinheim an der Bergstrasse, Germany). 2023 02; 19(6):e2205933. doi: 10.1002/smll.202205933. [PMID: 36461678]
Yu Long, Songyu Liu, Jinyan Wan, Yulu Zhang, Dan Li, Shuang Yu, Ai Shi, Nan Li, Fei He. Brain targeted borneol-baicalin liposome improves blood-brain barrier integrity after cerebral ischemia-reperfusion injury via inhibiting HIF-1α/VEGF/eNOS/NO signal pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Feb; 160(?):114240. doi: 10.1016/j.biopha.2023.114240. [PMID: 36731339]
Zhiyuan Hao, Zheyu Zhang, Yuhang Zhao, Dongsheng Wang. Baicalin Reduces Immune Cell Infiltration by Inhibiting Inflammation and Protecting Tight Junctions in Ischemic Stroke Injury. The American journal of Chinese medicine. 2023 Jan; ?(?):1-18. doi: 10.1142/s0192415x23500180. [PMID: 36661075]
Xiaolu Chen, Jian Liu, Yanqiu Sun, Jianting Wen, Qin Zhou, Xiang Ding, Xianheng Zhang. Correlation analysis of differentially expressed long non-coding RNA HOTAIR with PTEN/PI3K/AKT pathway and inflammation in patients with osteoarthritis and the effect of baicalin intervention. Journal of orthopaedic surgery and research. 2023 Jan; 18(1):34. doi: 10.1186/s13018-023-03505-1. [PMID: 36635778]
Rong Cai, Yan-Ping Zhou, Yun-Hai Li, Jin-Jin Zhang, Zuo-Wei Hu. Baicalin Blocks Colon Cancer Cell Cycle and Inhibits Cell Proliferation through miR-139-3p Upregulation by Targeting CDK16. The American journal of Chinese medicine. 2023; 51(1):189-203. doi: 10.1142/s0192415x23500118. [PMID: 36599649]
Le-Yuan Shang, Ming-Hao Zhou, Si-Yuan Cao, Min Zhang, Peng-Jiao Wang, Shuo Zhang, Xiao-Xia Meng, Qi-Mei Yang, Xiu-Li Gao. Effect of polyethylene glycol 400 on the pharmacokinetics and tissue distribution of baicalin by intravenous injection based on the enzyme activity of UGT1A8/1A9. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2023 Jan; 180(?):106328. doi: 10.1016/j.ejps.2022.106328. [PMID: 36379359]
Qi Wu, Xingxing Wu, Mao Wang, Kexin Liu, Yuge Li, Xiaoyu Ruan, Lin Qian, Lingchang Meng, Zhiting Sun, Lei Zhu, Jing Wu, Genglin Mu. Therapeutic Mechanism of Baicalin in Experimental Colitis Analyzed Using Network Pharmacology and Metabolomics. Drug design, development and therapy. 2023; 17(?):1007-1024. doi: 10.2147/dddt.s399290. [PMID: 37025160]
Lingli Hu, Lulu Li, Chen Yan, Yuxue Cao, Xiaohong Duan, Jing Sun. Baicalin Inhibits Airway Smooth Muscle Cells Proliferation through the RAS Signaling Pathway in Murine Asthmatic Airway Remodeling Model. Oxidative medicine and cellular longevity. 2023; 2023(?):4144138. doi: 10.1155/2023/4144138. [PMID: 36814956]
Panpan Feng, Yue Yang, Neng Liu, Sihang Wang. Baicalin regulates TLR4/IκBα/NFκB signaling pathway to alleviate inflammation in Doxorubicin related cardiotoxicity. Biochemical and biophysical research communications. 2022 12; 637(?):1-8. doi: 10.1016/j.bbrc.2022.10.061. [PMID: 36375245]
Lili Deng, Mingyue Ma, Shuying Li, Lin Zhou, Sun Ye, Juan Wang, Qiaoqiao Yang, Chunling Xiao. Protective effect and mechanism of baicalin on lung inflammatory injury in BALB/cJ mice induced by PM2.5. Ecotoxicology and environmental safety. 2022 Dec; 248(?):114329. doi: 10.1016/j.ecoenv.2022.114329. [PMID: 36442400]
Wentao Wang, Suying Hu, Jing Yang, Caijuan Zhang, Tong Zhang, Donghao Wang, Xiaoyan Cao, Zhezhi Wang. A Novel R2R3-MYB Transcription Factor SbMYB12 Positively Regulates Baicalin Biosynthesis in Scutellaria baicalensis Georgi. International journal of molecular sciences. 2022 Dec; 23(24):. doi: 10.3390/ijms232415452. [PMID: 36555123]
Ali Ahmadi, Zoha Mortazavi, Soghra Mehri, Hossein Hosseinzadeh. Protective and therapeutic effects of Scutellaria baicalensis and its main active ingredients baicalin and baicalein against natural toxicities and physical hazards: a review of mechanisms. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 2022 Dec; 30(2):351-366. doi: 10.1007/s40199-022-00443-x. [PMID: 35870110]
Ziwei Li, Yiting Liu, Jilin Wang, Xiaojiao Feng, Ebuka-Olisaemeka Nwafor, Ying Zhang, Rui Liu, Wenli Dang, Qingqing Zhang, Changxiang Yu, Jiaxin Pi, Zhidong Liu. Baicalin-berberine complex nanocrystals orally promote the co-absorption of two components. Drug delivery and translational research. 2022 12; 12(12):3017-3028. doi: 10.1007/s13346-022-01167-w. [PMID: 35476182]
Sihan Hu, Lan Jiang, Qi Yan, Chenyang Zhou, Xiaochuan Guo, Tong Chen, Siting Ma, Yimiao Luo, Caiyu Hu, Fumin Yang, Lishan Yuan, Xiao Ma, Jinhao Zeng. Evidence construction of baicalin for treating myocardial ischemia diseases: A preclinical meta-analysis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Dec; 107(?):154476. doi: 10.1016/j.phymed.2022.154476. [PMID: 36191551]
Haipeng Feng, Kai Zhang, Kang Zhang, Zhiting Guo, Qin Liu, Lei Wang, Xuezhi Wang, Zhengying Qiu, Guibo Wang, Jingyan Zhang, Jianxi Li. Antiviral activity and underlying mechanisms of baicalin against avian infectious bronchitis virus in vitro. Avian pathology : journal of the W.V.P.A. 2022 Dec; 51(6):574-589. doi: 10.1080/03079457.2022.2109453. [PMID: 35917182]
Jiafeng Li, Huixin Liu, Qiwang Lin, Huajiao Chen, Liya Liu, Hongjuan Liao, Ying Cheng, Xiuli Zhang, Zhenlong Wang, Aling Shen, Guolong Chen. Baicalin suppresses the migration and invasion of breast cancer cells via the TGF-β/lncRNA-MALAT1/miR-200c signaling pathway. Medicine. 2022 Nov; 101(46):e29328. doi: 10.1097/md.0000000000029328. [PMID: 36401368]
Nan Li, Zhiyue Zhao, Hongfei Ma, Yan Liu, Ebuka-Olisaemeka Nwafor, Shan Zhu, Linlin Jia, Xiaochen Pang, Zhenzhen Han, BaoCheng Tian, Hao Pan, Zhidong Liu, Weisan Pan. Optimization and Characterization of Low-Molecular-Weight Chitosan-Coated Baicalin mPEG-PLGA Nanoparticles for the Treatment of Cataract. Molecular pharmaceutics. 2022 11; 19(11):3831-3845. doi: 10.1021/acs.molpharmaceut.2c00341. [PMID: 36067066]
Huilian Shi, Fei Qiao, Weiting Lu, Kaiyue Huang, Yuanyuan Wen, Lifang Ye, Yuanyuan Chen. Baicalin improved hepatic injury of NASH by regulating NRF2/HO-1/NRLP3 pathway. European journal of pharmacology. 2022 Nov; 934(?):175270. doi: 10.1016/j.ejphar.2022.175270. [PMID: 36184988]
Alaa Ibrahim, Sara A Abdel Gaber, Mohamed Fawzi Kabil, Omar A H Ahmed-Farid, Anna K H Hirsch, Ibrahim M El-Sherbiny, Maha Nasr. Baicalin lipid nanocapsules for treatment of glioma: characterization, mechanistic cytotoxicity, and pharmacokinetic evaluation. Expert opinion on drug delivery. 2022 11; 19(11):1549-1560. doi: 10.1080/17425247.2022.2139370. [PMID: 36287914]
Ali Ahmadi, Zoha Mortazavi, Soghra Mehri, Hossein Hosseinzadeh. Scutellaria baicalensis and its constituents baicalin and baicalein as antidotes or protective agents against chemical toxicities: a comprehensive review. Naunyn-Schmiedeberg's archives of pharmacology. 2022 11; 395(11):1297-1329. doi: 10.1007/s00210-022-02258-8. [PMID: 35676380]
Minglong Bao, Yunfei Ma, Mei Liang, Xinyi Sun, Xianghong Ju, Yanhong Yong, Xiaoxi Liu. Research progress on pharmacological effects and new dosage forms of baicalin. Veterinary medicine and science. 2022 11; 8(6):2773-2784. doi: 10.1002/vms3.960. [PMID: 36271488]
Mingshuang Li, Conglin Ren. Exploring the protective mechanism of baicalin in treatment of atherosclerosis using endothelial cells deregulation model and network pharmacology. BMC complementary medicine and therapies. 2022 Oct; 22(1):257. doi: 10.1186/s12906-022-03738-3. [PMID: 36192741]
Salwa R Abo El-Ela, Randa A Zaghloul, Laila A Eissa. Promising cardioprotective effect of baicalin in doxorubicin-induced cardiotoxicity through targeting toll-like receptor 4/nuclear factor-κB and Wnt/β-catenin pathways. Nutrition (Burbank, Los Angeles County, Calif.). 2022 10; 102(?):111732. doi: 10.1016/j.nut.2022.111732. [PMID: 35816809]
Quanfu Zeng, Zhuxian Wang, Zhaoming Zhu, Yi Hu, Yuan Wang, Yaqi Xue, Yufan Wu, Yinglin Guo, Peiyi Liang, Hongkai Chen, Zeying Zheng, Chunyan Shen, Cuiping Jiang, Hongxia Zhu, Qun Shen, Yankui Yi, Hui Li, Zhijun Yang, Li Liu, Qiang Liu. Glycyrrhizin micellar nanocarriers for topical delivery of baicalin to the hair follicles: A targeted approach tailored for alopecia treatment. International journal of pharmaceutics. 2022 Sep; 625(?):122109. doi: 10.1016/j.ijpharm.2022.122109. [PMID: 35973589]
Yonggang Yan, Luhan Li, Kenan Wu, Gang Zhang, Liang Peng, Yanni Liang, Zheng Wang. A Combination of Baicalin and Berberine Hydrochloride Ameliorates Dextran Sulfate Sodium-Induced Colitis by Modulating Colon Gut Microbiota. Journal of medicinal food. 2022 Aug; 25(8):853-862. doi: 10.1089/jmf.2021.k.0173. [PMID: 35980327]
Lin Wang, Ting Feng, Zhilian Su, Chao Pi, Yumeng Wei, Ling Zhao. Latest research progress on anticancer effect of baicalin and its aglycone baicalein. Archives of pharmacal research. 2022 Aug; 45(8):535-557. doi: 10.1007/s12272-022-01397-z. [PMID: 35908250]
Meng Lan, Zhaodi Kong, Fengjie Liu, Tengteng Zou, Lihong Li, Tiange Cai, Huaqin Tian, Yu Cai. Activating caspase-8/Bid/ROS signaling to promote apoptosis of breast cancer cells by folate-modified albumin baicalin-loaded nanoparticles. Nanotechnology. 2022 Aug; 33(43):. doi: 10.1088/1361-6528/ac197b. [PMID: 34330116]
Xiumei Yan, Yulong Zhang, Ying Peng, Xiaobo Li. The water extract of Radix scutellariae, its total flavonoids and baicalin inhibited CYP7A1 expression, improved bile acid, and glycolipid metabolism in T2DM mice. Journal of ethnopharmacology. 2022 Jul; 293(?):115238. doi: 10.1016/j.jep.2022.115238. [PMID: 35351576]
Risha Ganguly, Ashutosh Gupta, Abhay K Pandey. Role of baicalin as a potential therapeutic agent in hepatobiliary and gastrointestinal disorders: A review. World journal of gastroenterology. 2022 Jul; 28(26):3047-3062. doi: 10.3748/wjg.v28.i26.3047. [PMID: 36051349]
Lidan Cui, Tianyi Yuan, Zuomei Zeng, Dianlong Liu, Chenxiao Liu, Jian Guo, Yucai Chen. Mechanistic and therapeutic perspectives of baicalin and baicalein on pulmonary hypertension: A comprehensive review. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jul; 151(?):113191. doi: 10.1016/j.biopha.2022.113191. [PMID: 35643068]
Yu Long, Yan Xiang, Songyu Liu, Yulu Zhang, Jinyan Wan, Zhimin Ci, Mingquan Cui, Lin Shen, Nan Li, Yongmei Guan. Macrophage membrane modified baicalin liposomes improve brain targeting for alleviating cerebral ischemia reperfusion injury. Nanomedicine : nanotechnology, biology, and medicine. 2022 07; 43(?):102547. doi: 10.1016/j.nano.2022.102547. [PMID: 35292367]
Pan Li, Yuwei Chen, Xiumei Ke, Ruoyu Zhang, Ling Zuo, Meng Wang, Zhiwei Chen, Xianqin Luo, Jianwei Wang. Baicalin ameliorates alcohol-induced hepatic steatosis by suppressing SREBP1c elicited PNPLA3 competitive binding to ATGL. Archives of biochemistry and biophysics. 2022 06; 722(?):109236. doi: 10.1016/j.abb.2022.109236. [PMID: 35429444]
Yang Lin, Zi-Yuan Wang, Ma-Jie Wang, Zheng-Meng Jiang, Ya-Qiu Qin, Tian-Qing Huang, Yu Song, Hui-Ting Liang, E-Hu Liu. Baicalin attenuate diet-induced metabolic syndrome by improving abnormal metabolism and gut microbiota. European journal of pharmacology. 2022 Jun; 925(?):174996. doi: 10.1016/j.ejphar.2022.174996. [PMID: 35513018]
Chuanhua Zhai, Debing Wang. Baicalin regulates the development of pediatric asthma via upregulating microRNA-103 and mediating the TLR4/NF-κB pathway. Journal of receptor and signal transduction research. 2022 Jun; 42(3):230-240. doi: 10.1080/10799893.2021.1900865. [PMID: 33730981]
Long Fang, Hui-Fen Wang, Yan-Ming Chen, Ru-Xue Bai, Shi-Yu Du. Baicalin confers hepatoprotective effect against alcohol-associated liver disease by upregulating microRNA-205. International immunopharmacology. 2022 Jun; 107(?):108553. doi: 10.1016/j.intimp.2022.108553. [PMID: 35358777]
Shunfen Zhang, Ruqing Zhong, Shanlong Tang, Hui Han, Liang Chen, Hongfu Zhang. Baicalin Alleviates Short-Term Lincomycin-Induced Intestinal and Liver Injury and Inflammation in Infant Mice. International journal of molecular sciences. 2022 May; 23(11):. doi: 10.3390/ijms23116072. [PMID: 35682750]
Xiaolei Yang, Guanghao Zhu, Ying Zhang, Xubo Wu, Bei Liu, Ye Liu, Qing Yang, Wandi Du, Jingru Liang, Jiarong Hu, Ping Yang, Guangbo Ge, Weimin Cai, Guo Ma. Inhibition of Human UDP-Glucuronosyltransferases1A1-Mediated Bilirubin Glucuronidation by the Popular Flavonoids Baicalein, Baicalin, and Hyperoside Is Responsible for Herb (Shuang-Huang-Lian)-Induced Jaundice. Drug metabolism and disposition: the biological fate of chemicals. 2022 05; 50(5):552-565. doi: 10.1124/dmd.121.000714. [PMID: 35241486]
Wanli Ji, Yan Huo, Yu Zhang, Xinhong Wang, Yifan Zhang. Revealing therapeutic targets and mechanism of baicalin for anti-chronic gastritis using proteomic analysis of the gastric tissue. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2022 Apr; 1196(?):123214. doi: 10.1016/j.jchromb.2022.123214. [PMID: 35303499]
Xiaoqi Sun, Michael Pisano, Longjin Xu, Fumou Sun, Jie Xu, Wei Zheng, Xiujuan Liu, Yanyu Zhang, Runjie Sun, Xing Cui. Baicalin regulates autophagy to interfere with small intestinal acute graft-versus-host disease. Scientific reports. 2022 04; 12(1):6551. doi: 10.1038/s41598-022-10564-7. [PMID: 35449393]
Zhu Changle, Feng Cuiling, Feng Feng, Yao Xiaoqin, Wang Guishu, Shi Liangtian, Zheng Jiakun. Baicalin inhibits inflammation of lipopolysaccharide-induced acute lung injury toll like receptor-4/myeloid differentiation primary response 88/nuclear factor-kappa B signaling pathway. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2022 04; 42(2):200-212. doi: 10.19852/j.cnki.jtcm.20211214.004. [PMID: 35473340]
Linjiang Song, Shaomi Zhu, Chi Liu, Qinxiu Zhang, Xin Liang. Baicalin triggers apoptosis, inhibits migration, and enhances anti-tumor immunity in colorectal cancer via TLR4/NF-κB signaling pathway. Journal of food biochemistry. 2022 03; 46(3):e13703. doi: 10.1111/jfbc.13703. [PMID: 33742464]
Mengmeng Zhang, Xuan Xin, Guanglei Zhao, Yucong Zou, Xiao-Feng Li. In vitro absorption and lipid-lowering activity of baicalin esters synthesized by whole-cell catalyzed esterification. Bioorganic chemistry. 2022 03; 120(?):105628. doi: 10.1016/j.bioorg.2022.105628. [PMID: 35066316]
Chun-Xiang He, Wen-Jing Yu, Miao Yang, Ze Li, Xiao-Fang Xia, Ping Li, Shao-Wu Cheng, Zhen-Yan Song. [Baicalin inhibits LPS/IFN-γ-induced inflammation via TREM2/TLR4/NF-κB pathway in BV2 cells]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Mar; 47(6):1603-1610. doi: 10.19540/j.cnki.cjcmm.20211103.401. [PMID: 35347959]
Yinzhu Hou, Zuqing Liang, Luyu Qi, Chao Tang, Xingkai Liu, Jilin Tang, Yao Zhao, Yanyan Zhang, Tiantian Fang, Qun Luo, Shijun Wang, Fuyi Wang. Baicalin Targets HSP70/90 to Regulate PKR/PI3K/AKT/eNOS Signaling Pathways. Molecules (Basel, Switzerland). 2022 Feb; 27(4):. doi: 10.3390/molecules27041432. [PMID: 35209223]
Tian Xu, Xueqian Wang, Chongyang Ma, Jing Ji, Wenxiu Xu, Qi Shao, Xuejing Liao, Ying Li, Fafeng Cheng, Qingguo Wang. Identification of potential regulating effect of baicalin on NFκB/CCL2/CCR2 signaling pathway in rats with cerebral ischemia by antibody-based array and bioinformatics analysis. Journal of ethnopharmacology. 2022 Feb; 284(?):114773. doi: 10.1016/j.jep.2021.114773. [PMID: 34699947]
Ming Yang, Xiaoyan Zhu, Feida Fu, Qinghua Guo, Xiaopu Zhu, Yang Xu, Xiaotian Yan, Xinya He, Xu Wang. Baicalin Ameliorates Inflammatory Response in a Mouse Model of Rhinosinusitis via Regulating the Treg/Th17 Balance. Ear, nose, & throat journal. 2022 Feb; 101(2_suppl):8S-16S. doi: 10.1177/0145561320986058. [PMID: 33507111]
Lan Wang, Yan-Fang Xian, Steven King Fan Loo, Siu Po Ip, Wen Yang, Wood Yee Chan, Zhi-Xiu Lin, Justin Che Yuen Wu. Baicalin ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice through modulating skin barrier function, gut microbiota and JAK/STAT pathway. Bioorganic chemistry. 2022 02; 119(?):105538. doi: 10.1016/j.bioorg.2021.105538. [PMID: 34929516]
Ganggang Li, Shiyue Zhang, Yating Cheng, Ye Lu, Zhixia Jia, Xiaohui Yang, Shaodan Zhang, Wenxiang Guo, Lin Pei. Baicalin suppresses neuron autophagy and apoptosis by regulating astrocyte polarization in pentylenetetrazol-induced epileptic rats and PC12 cells. Brain research. 2022 01; 1774(?):147723. doi: 10.1016/j.brainres.2021.147723. [PMID: 34780748]
Zhenyan Song, Chunxiang He, Wenjing Yu, Miao Yang, Ze Li, Ping Li, Xu Zhu, Chen Xiao, Shaowu Cheng. Baicalin Attenuated Aβ 1-42-Induced Apoptosis in SH-SY5Y Cells by Inhibiting the Ras-ERK Signaling Pathway. BioMed research international. 2022; 2022(?):9491755. doi: 10.1155/2022/9491755. [PMID: 35528169]