Hydroxyurea (BioDeep_00000003458)
Secondary id: BioDeep_00000269153
human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs
代谢物信息卡片
N-Carbamoylhydroxylamine
化学式: CH4N2O2 (76.0272764)
中文名称: 羟基脲, 羟基脲
谱图信息:
最多检出来源 Homo sapiens(blood) 0.11%
分子结构信息
SMILES: C(=O)(N)NO
InChI: InChI=1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)
描述信息
Hydroxyurea is only found in individuals that have used or taken this drug. It is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. [PubChem]Hydroxyurea is converted to a free radical nitroxide (NO) in vivo, and transported by diffusion into cells where it quenches the tyrosyl free radical at the active site of the M2 protein subunit of ribonucleotide reductase, inactivating the enzyme. The entire replicase complex, including ribonucleotide reductase, is inactivated and DNA synthesis is selectively inhibited, producing cell death in S phase and synchronization of the fraction of cells that survive. Repair of DNA damaged by chemicals or irradiation is also inhibited by hydroxyurea, offering potential synergy between hydroxyurea and radiation or alkylating agents. Hydroxyurea also increases the level of fetal hemoglobin, leading to a reduction in the incidence of vasoocclusive crises in sickle cell anemia. Levels of fetal hemoglobin increase in response to activation of soluble guanylyl cyclase (sGC) by hydroxyurea-derived NO.
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C272 - Antimetabolite
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
C471 - Enzyme Inhibitor > C2150 - Ribonucleotide Reductase Inhibitor
D006401 - Hematologic Agents > D000986 - Antisickling Agents
D000970 - Antineoplastic Agents
KEIO_ID H104
同义名列表
25 个代谢物同义名
N-Carbamoylhydroxylamine; Carbamyl hydroxamic acid; Carbamohydroxyamic acid; Carbamohydroxamic acid; Carbamohydroximic acid; Carbamyl hydroxamate; Carbamohydroxamate; Carbamohydroximate; Hydroxicarbamidum; Hydroxycarbamidum; Hydroxycarbamine; Hidroxicarbamida; Hydroxycarbamide; Idrossicarbamide; Hydroxyharnstoff; Carbamoyl oxime; Hydroxycarbamid; N-HYDROXYUREA; Hydroxylurea; hydroxyurea; Oncocarbide; Oxyurea; Hydrea; Droxia; HU
数据库引用编号
22 个数据库交叉引用编号
- ChEBI: CHEBI:44423
- KEGG: C07044
- KEGGdrug: D00341
- PubChem: 3657
- HMDB: HMDB0015140
- Metlin: METLIN4068
- DrugBank: DB01005
- ChEMBL: CHEMBL467
- Wikipedia: Hydroxyurea
- MeSH: Hydroxyurea
- MetaCyc: HYDROXY-UREA
- chemspider: 3530
- CAS: 127-07-1
- MoNA: KO003159
- MoNA: KO003160
- MoNA: KO003161
- MoNA: KO003158
- PMhub: MS000009707
- PubChem: 9256
- PDB-CCD: NHY
- NIKKAJI: J2.937H
- RefMet: Hydroxyurea
分类词条
相关代谢途径
Reactome(0)
BioCyc(2)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(1)
- D-cycloserine biosynthesis:
O-acetyl-L-serine + hydroxyurea ⟶ O-ureido-L-serine + H+ + acetate
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
- 1827580 Streptomyces nigra: 10.3389/FMICB.2018.01587
- 1827580 Streptomyces nigra: 10.3389/FMICB.2018.01587
- 9606 Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Aneta Żabka, Natalia Gocek, Justyna Teresa Polit, Janusz Maszewski. Oxidative replication stress induced by long-term exposure to hydroxyurea in root meristem cells of Vicia faba.
Plant cell reports.
2024 Mar; 43(4):87. doi:
10.1007/s00299-024-03187-x. [PMID: 38460026] - Saranya Dharmaraj, Akey Krishna Swaroop, Mariappan Esakkimuthukumar, Preeya Negi, Selvaraj Jubie. "In-silico Design and Development of Novel Hydroxyurea Lipid Drug Conjugates for Breast Cancer Therapy Targeting PI3K/AKT/mTOR Pathway".
Drug research.
2024 Jan; 74(1):32-41. doi:
10.1055/a-2213-8457. [PMID: 38211596] - Aneta Żabka, Natalia Gocek, Justyna Teresa Polit, Janusz Maszewski. Epigenetic modifications evidenced by isolation of proteins on nascent DNA and immunofluorescence in hydroxyurea-treated root meristem cells of Vicia faba.
Planta.
2023 Oct; 258(5):95. doi:
10.1007/s00425-023-04249-2. [PMID: 37814174] - Floris Haijer, Shiva Koets-Shajari, Janette Heegsma, Sandra Serna-Salas, Tjasso Blokzijl, Manon Buist-Homan, Han Moshage, Klaas Nico Faber. Hydroxyurea attenuates hepatic stellate cell proliferation in vitro and liver fibrogenesis in vivo.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2023 09; 37(9):e23124. doi:
10.1096/fj.202300920r. [PMID: 37552464] - Zozan Guleken, Zeynep Ceylan, Aynur Aday, Ayşe Gül Bayrak, İpek Yönal Hindilerden, Meliha Nalçacı, Paweł Jakubczyk, Dorota Jakubczyk, Monika Kula-Maximenko, Joanna Depciuch. Detection of primary myelofibrosis in blood serum via Raman spectroscopy assisted by machine learning approaches; correlation with clinical diagnosis.
Nanomedicine : nanotechnology, biology, and medicine.
2023 Aug; ?(?):102706. doi:
10.1016/j.nano.2023.102706. [PMID: 37633405] - Kai Wang, Wentao Zhou, Xiangyu Jin, Xuwei Shang, Xiaomei Wu, Lijuan Wen, Sufen Li, Yiling Hong, Jia Ke, Yichong Xu, Hong Yuan, Fuqiang Hu. Enhanced brain delivery of hypoxia-sensitive liposomes by hydroxyurea for rescue therapy of hyperacute ischemic stroke.
Nanoscale.
2023 Jul; 15(27):11625-11646. doi:
10.1039/d3nr01071f. [PMID: 37377137] - Abhishek Gour, Dilpreet Kour, Ashish Dogra, Diksha Manhas, Priya Wazir, Sanjeev Kumar Digra, Ajay Kumar, Utpal Nandi. Epicatechin exerts dual action to shield sickling and hydroxyurea-induced myelosuppression: Implication in sickle cell anemia management.
Toxicology and applied pharmacology.
2022 08; 449(?):116113. doi:
10.1016/j.taap.2022.116113. [PMID: 35691369] - Muhammad Behroz Naeem Khan, Fizza Iftikhar, Tajwali Khan, Asma Danish, Tahir Shamsi, Syed Ghulam Musharraf, Amna Jabbar Siddiqui. IVS I-5 (G > C) is associated with changes to the RBC membrane lipidome in response to hydroxyurea treatment in β-thalassemia patients.
Molecular omics.
2022 07; 18(6):534-544. doi:
10.1039/d2mo00008c. [PMID: 35578989] - Jessi Cai, Amber Chen-Goodspeed, Modupe Idowu. Risk and protective factors for severe COVID-19 infection in a cohort of patients with sickle cell disease.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research.
2022 06; 70(5):1243-1246. doi:
10.1136/jim-2021-002196. [PMID: 35260481] - Muhammad Behroz Naeem Khan, Fizza Iftikhar, Muhammad Ali, Asma Danish, Tahir Shamsi, Syed Ghulam Musharraf, Amna Jabbar Siddiqui. XMN polymorphism along with HU administration renders alterations to RBC membrane lipidome in β-thalassemia patients.
Chemistry and physics of lipids.
2022 05; 244(?):105195. doi:
10.1016/j.chemphyslip.2022.105195. [PMID: 35288127] - Barbara L Kroner, Jane S Hankins, Norma Pugh, Abdullah Kutlar, Allison A King, Nirmish R Shah, Julie Kanter, Jeffrey Glassberg, Marsha Treadwell, Victor R Gordeuk. Pregnancy outcomes with hydroxyurea use in women with sickle cell disease.
American journal of hematology.
2022 05; 97(5):603-612. doi:
10.1002/ajh.26495. [PMID: 35142007] - Wouter S Hoogenboom, Tharun T Alamuri, Daniel M McMahon, Nino Balanchivadze, Vrushali Dabak, William B Mitchell, Kerry B Morrone, Deepa Manwani, Tim Q Duong. Clinical outcomes of COVID-19 in patients with sickle cell disease and sickle cell trait: A critical appraisal of the literature.
Blood reviews.
2022 05; 53(?):100911. doi:
10.1016/j.blre.2021.100911. [PMID: 34838342] - A M Brandow, R I Liem. Advances in the diagnosis and treatment of sickle cell disease.
Journal of hematology & oncology.
2022 03; 15(1):20. doi:
10.1186/s13045-022-01237-z. [PMID: 35241123] - Václav Bačovský, Tomáš Janíček, Roman Hobza. The Sister Chromatid Division of the Heteromorphic Sex Chromosomes in Silene Species and Their Transmissibility towards the Mitosis.
International journal of molecular sciences.
2022 Feb; 23(5):. doi:
10.3390/ijms23052422. [PMID: 35269563] - Lili Li, Jie Wang, Zijia Yang, Yiling Zhao, Hui Jiang, Luguang Jiang, Wenya Hou, Risheng Ye, Qun He, Martin Kupiec, Brian Luke, Qinhong Cao, Zhi Qi, Zhen Li, Huiqiang Lou. Metabolic remodeling maintains a reducing environment for rapid activation of the yeast DNA replication checkpoint.
The EMBO journal.
2022 02; 41(4):e108290. doi:
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Pediatric research.
2022 02; 91(3):539-544. doi:
10.1038/s41390-021-01495-6. [PMID: 33824452] - Jong-Jer Lee, Guo-Ping Chang-Chien, Sufan Lin, Yu-Ting Hsiao, Mu-Chan Ke, Alexander Chen, Tsu-Kung Lin. 5-Lipoxygenase Inhibition Protects Retinal Pigment Epithelium from Sodium Iodate-Induced Ferroptosis and Prevents Retinal Degeneration.
Oxidative medicine and cellular longevity.
2022; 2022(?):1792894. doi:
10.1155/2022/1792894. [PMID: 35251467] - ShaSha Li, JiaWei Kong, LiXia Yu, QiFeng Liu. Abnormally decreased renal Klotho is linked to endoplasmic reticulum-associated degradation in mice.
International journal of medical sciences.
2022; 19(2):321-330. doi:
10.7150/ijms.68137. [PMID: 35165517] - Moayed Ben Moftah, Asma Eswayah. Repurposing of Hydroxyurea Against COVID-19: A Promising Immunomodulatory Role.
Assay and drug development technologies.
2022 01; 20(1):55-62. doi:
10.1089/adt.2021.090. [PMID: 34990284] - Pamela L Brito, Alisson F Dos Santos, Hanan Chweih, Maria E Favero, Erica M F Gotardo, Juliete A F Silva, Flavia C Leonardo, Carla F Franco-Penteado, Mariana G de Oliveira, Wilson A Ferreira, Bruna C Zaidan, Athanase Billis, Giorgio Baldanzi, Denise A Mashima, Edson Antunes, Sara T Olalla Saad, Fernando F Costa, Nicola Conran. Reduced blood pressure in sickle cell disease is associated with decreased angiotensin converting enzyme (ACE) activity and is not modulated by ACE inhibition.
PloS one.
2022; 17(2):e0263424. doi:
10.1371/journal.pone.0263424. [PMID: 35113975] - Nalan Yurtsever, Vijay Nandi, Yonah Ziemba, Patricia A Shi. Prognostic factors associated with COVID-19 related severity in sickle cell disease.
Blood cells, molecules & diseases.
2021 12; 92(?):102627. doi:
10.1016/j.bcmd.2021.102627. [PMID: 34823201] - Francine Chenou, Bidossessi Wilfried Hounkpe, Igor de Farias Domingos, Wouitchékpo Vincent Tonassé, Thais Helena Chaves Batista, Rodrigo Marcionilo Santana, Gabriela da Silva Arcanjo, Adekunle Emmanuel Alagbe, Aderson da Silva Araújo, Antonio Roberto Lucena-Araújo, Marcos Andre Cavalcanti Bezerra, Fernando Ferreira Costa, Maria de Fátima Sonati, Erich Vinicius De Paula, Magnun Nueldo Nunes Dos Santos. Effect of hydroxyurea therapy on intravascular hemolysis and endothelial dysfunction markers in sickle cell anemia patients.
Annals of hematology.
2021 Nov; 100(11):2669-2676. doi:
10.1007/s00277-021-04636-3. [PMID: 34453189] - Thomas Eekhout, José Antonio Pedroza-Garcia, Pooneh Kalhorzadeh, Geert De Jaeger, Lieven De Veylder. A Mutation in DNA Polymerase α Rescues WEE1KO Sensitivity to HU.
International journal of molecular sciences.
2021 Aug; 22(17):. doi:
10.3390/ijms22179409. [PMID: 34502313] - Amy E Blum, William G Tsiaras, Jacqueline M Kemp. Hydroxyurea-induced genital ulcers and erosions: Two case reports.
Journal of tissue viability.
2021 Aug; 30(3):462-464. doi:
10.1016/j.jtv.2021.06.001. [PMID: 34147315] - Jianjun Tang, Chuang Zhang, Jingjing Lin, Peng Duan, Jian Long, Hongyan Zhu. ALOX5-5-HETE promotes gastric cancer growth and alleviates chemotherapy toxicity via MEK/ERK activation.
Cancer medicine.
2021 08; 10(15):5246-5255. doi:
10.1002/cam4.4066. [PMID: 34121352] - Pratik A Patel, Stacey A Lapp, Gabrielle Grubbs, Venkata V Edara, Christina A Rostad, Claire L Stokes, Melinda G Pauly, Evan J Anderson, Anne Piantadosi, Mehul S Suthar, Surender Khurana, Himalee S Sabnis. Immune responses and therapeutic challenges in paediatric patients with new-onset acute myeloid leukaemia and concomitant COVID-19.
British journal of haematology.
2021 08; 194(3):549-553. doi:
10.1111/bjh.17517. [PMID: 34096051] - Madelyn C Huang, Katie J Turner, Molly Vallant, Veronica G Robinson, Yi Lu, Catherine J Price, Timothy R Fennell, Melanie A Silinski, Suramya Waidyanatha, Kristen R Ryan, Sherry R Black, Reshan A Fernando, Barry S McIntyre. Tolerability and age-dependent toxicokinetics following perinatal hydroxyurea treatment in Sprague Dawley rats.
Journal of applied toxicology : JAT.
2021 07; 41(7):1007-1020. doi:
10.1002/jat.4087. [PMID: 33241551] - Yang Liu, Lu Wang, Xin Xu, Yue Yuan, Bo Zhang, Zeyang Li, Yuchen Xie, Rui Yan, Zeqi Zheng, Jianguo Ji, Johanne M Murray, Antony M Carr, Daochun Kong. The intra-S phase checkpoint directly regulates replication elongation to preserve the integrity of stalled replisomes.
Proceedings of the National Academy of Sciences of the United States of America.
2021 06; 118(24):. doi:
10.1073/pnas.2019183118. [PMID: 34108240] - Philippe Connes, Berenike Möckesch, Emilienne Tudor Ngo Sock, Marie-Dominique Hardy-Dessources, Karen Reminy, Sarah Skinner, Marie Billaud, Elie Nader, Benoit Tressieres, Maryse Etienne-Julan, Nicolas Guillot, Nathalie Lemonne, Olivier Hue, Marc Romana, Sophie Antoine-Jonville. Oxidative stress, inflammation, blood rheology, and microcirculation in adults with sickle cell disease: Effects of hydroxyurea treatment and impact of sickle cell syndrome.
European journal of haematology.
2021 Jun; 106(6):800-807. doi:
10.1111/ejh.13607. [PMID: 33629431] - Slimane Allali, Melissa Taylor, Joséphine Brice, Mariane de de Montalembert. Chronic organ injuries in children with sickle cell disease.
Haematologica.
2021 06; 106(6):1535-1544. doi:
10.3324/haematol.2020.271353. [PMID: 33626864] - Xinlin Xu, Yixi Xu, Ruiyuan Guo, Ran Xu, Congcong Fu, Mengtan Xing, Hiroyuki Sasanuma, Qing Li, Minoru Takata, Shunichi Takeda, Rong Guo, Dongyi Xu. Fanconi anemia proteins participate in a break-induced-replication-like pathway to counter replication stress.
Nature structural & molecular biology.
2021 06; 28(6):487-500. doi:
10.1038/s41594-021-00602-9. [PMID: 34117478] - Crystal M Taylor, Malgorzata Kasztan, Randee Sedaka, Patrick A Molina, Luke S Dunaway, Jennifer S Pollock, David M Pollock. Hydroxyurea improves nitric oxide bioavailability in humanized sickle cell mice.
American journal of physiology. Regulatory, integrative and comparative physiology.
2021 05; 320(5):R630-R640. doi:
10.1152/ajpregu.00205.2020. [PMID: 33624556] - Claire Pressiat, Marie-Georgine Rakotoson, Anoosha Habibi, Caroline Barau, Raphaele Arrouasse, Frédéric Galactéros, Thomas Stehlé, Vincent Audard, Anne Hulin, Pablo Bartolucci. Impact of renal function on hydroxyurea exposure in sickle-cell disease patients.
British journal of clinical pharmacology.
2021 05; 87(5):2274-2285. doi:
10.1111/bcp.14653. [PMID: 33217005] - Marcelina W Musiałek, Joanna Deckert, Dorota Rybaczek. Hydroxyurea and Caffeine Impact pRb-like Protein-Dependent Chromatin Architecture Profiles in Interphase Cells of Vicia faba.
International journal of molecular sciences.
2021 Apr; 22(9):. doi:
10.3390/ijms22094572. [PMID: 33925461] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Animesh Pardanani. Systemic mastocytosis in adults: 2021 Update on diagnosis, risk stratification and management.
American journal of hematology.
2021 04; 96(4):508-525. doi:
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Journal of clinical pharmacology.
2021 04; 61(4):547-554. doi:
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BMJ case reports.
2021 Mar; 14(3):. doi:
10.1136/bcr-2020-237545. [PMID: 33674289] - Paulo R Ribeiro, Rozana Dos S Teixeira, Alzenir R Souza, Tayla C S Pereira, Elisangela F Boffo, Maria G A Carosio, Antonio G Ferreira, Regina V Oliveira, Luiz E A Rodrigues, Jacqueline de J Silva, Amancio J de Souza, Ana Marice T Ladeia. Blood plasma metabolomics of children and adolescents with sickle cell anaemia treated with hydroxycarbamide: a new tool for uncovering biochemical alterations.
British journal of haematology.
2021 03; 192(5):922-931. doi:
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Orphanet journal of rare diseases.
2021 03; 16(1):114. doi:
10.1186/s13023-021-01757-w. [PMID: 33648529] - Yuncheng Man, Erdem Kucukal, Ran An, Allison Bode, Jane A Little, Umut A Gurkan. Standardized microfluidic assessment of red blood cell-mediated microcapillary occlusion: Association with clinical phenotype and hydroxyurea responsiveness in sickle cell disease.
Microcirculation (New York, N.Y. : 1994).
2021 02; 28(2):e12662. doi:
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Blood advances.
2021 01; 5(1):207-215. doi:
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The Journal of clinical investigation.
2021 01; 131(1):. doi:
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Journal of clinical pharmacology.
2021 01; 61(1):41-51. doi:
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Pharmacology.
2021; 106(5-6):316-322. doi:
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Pharmacology.
2021; 106(7-8):451-452. doi:
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Transfusion.
2021 01; 61(1):246-254. doi:
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Scientific reports.
2020 11; 10(1):18982. doi:
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Pediatric blood & cancer.
2020 11; 67(11):e28579. doi:
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Prostaglandins, leukotrienes, and essential fatty acids.
2020 10; 161(?):102174. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Oct; 1154(?):122283. doi:
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International journal of hematology.
2020 Oct; 112(4):584-591. doi:
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Cells.
2020 09; 9(10):. doi:
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Pediatric blood & cancer.
2020 08; 67(8):e28250. doi:
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British journal of haematology.
2020 08; 190(4):e195-e198. doi:
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Blood.
2020 07; 136(2):154-155. doi:
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Blood.
2020 07; 136(2):247-256. doi:
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Journal of natural products.
2020 06; 83(6):1909-1918. doi:
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Blood.
2020 06; 135(25):2320-2322. doi:
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Toxicological sciences : an official journal of the Society of Toxicology.
2020 06; 175(2):220-235. doi:
10.1093/toxsci/kfaa037. [PMID: 32170957] - Enrico M Novelli. COVID-19 and SCA: an old friend comes to the rescue.
Blood.
2020 05; 135(22):1925-1926. doi:
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Blood.
2020 05; 135(22):1997-1999. doi:
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Aging.
2020 05; 12(9):8473-8483. doi:
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Annals of hematology.
2020 May; 99(5):937-945. doi:
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American journal of hematology.
2020 05; 95(5):456-464. doi:
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Scientific reports.
2020 03; 10(1):5016. doi:
10.1038/s41598-020-62086-9. [PMID: 32193460] - John F Tisdale, Swee Lay Thein, William A Eaton. Treating sickle cell anemia.
Science (New York, N.Y.).
2020 03; 367(6483):1198-1199. doi:
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mSphere.
2020 03; 5(2):. doi:
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Biomedical chromatography : BMC.
2020 Mar; 34(3):e4753. doi:
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Cytokine.
2020 03; 127(?):154933. doi:
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Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.
2020 Jan; 26(?):1076029619895111. doi:
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Acta cirurgica brasileira.
2020; 35(3):e202000301. doi:
10.1590/s0102-865020200030000001. [PMID: 32401830] - Gaber El-Saber Batiha, Amany Magdy Beshbishy, Oluyomi Stephen Adeyemi, Eman Nadwa, Eman Rashwan, Naoaki Yokoyama, Ikuo Igarashi. Safety and efficacy of hydroxyurea and eflornithine against most blood parasites Babesia and Theileria.
PloS one.
2020; 15(2):e0228996. doi:
10.1371/journal.pone.0228996. [PMID: 32053698] - Caroline Conceição da Guarda, Sètondji Cocou Modeste Alexandre Yahouédéhou, Rayra Pereira Santiago, Joelma Santana Dos Santos Neres, Camila Felix de Lima Fernandes, Milena Magalhães Aleluia, Camylla Vilas Boas Figueiredo, Luciana Magalhães Fiuza, Suellen Pinheiro Carvalho, Rodrigo Mota de Oliveira, Cleverson Alves Fonseca, Uche Samuel Ndidi, Valma Maria Lopes Nascimento, Larissa Carneiro Rocha, Marilda Souza Goncalves. Sickle cell disease: A distinction of two most frequent genotypes (HbSS and HbSC).
PloS one.
2020; 15(1):e0228399. doi:
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Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.
2020 Jan; 26(?):1076029620955240. doi:
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Scientific reports.
2019 12; 9(1):19362. doi:
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Blood advances.
2019 11; 3(22):3700-3708. doi:
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American journal of hematology.
2019 11; 94(11):E299-E301. doi:
10.1002/ajh.25614. [PMID: 31407373] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Ida Sofie Grønningsæter, Hanne Kristin Fredly, Bjørn Tore Gjertsen, Kimberley Joanne Hatfield, Øystein Bruserud. Systemic Metabolomic Profiling of Acute Myeloid Leukemia Patients before and During Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid, Valproic Acid, and Low-Dose Chemotherapy.
Cells.
2019 10; 8(10):. doi:
10.3390/cells8101229. [PMID: 31658693] - Nan Nitra Than, Htoo Htoo Kyaw Soe, Senthil K Palaniappan, Adinegara Bl Abas, Lucia De Franceschi. Magnesium for treating sickle cell disease.
The Cochrane database of systematic reviews.
2019 09; 9(?):CD011358. doi:
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British journal of haematology.
2019 09; 186(6):879-886. doi:
10.1111/bjh.15996. [PMID: 31140594] - Feng Yang, Flora Teoh, Alrina Shin Min Tan, Yongbing Cao, Norman Pavelka, Judith Berman. Aneuploidy Enables Cross-Adaptation to Unrelated Drugs.
Molecular biology and evolution.
2019 08; 36(8):1768-1782. doi:
10.1093/molbev/msz104. [PMID: 31028698] - Frank Park, Hitesh Soni, Jeffrey D Pressly, Adebowale Adebiyi. Acute hydroxyurea treatment reduces tubular damage following bilateral ischemia-reperfusion injury in a mouse model of sickle cell disease.
Biochemical and biophysical research communications.
2019 07; 515(1):72-76. doi:
10.1016/j.bbrc.2019.05.116. [PMID: 31128920] - Adil A Al-Khatti, Ahmed M Alkhunaizi. Additive effect of sirolimus and hydroxycarbamide on fetal haemoglobin level in kidney transplant patients with sickle cell disease.
British journal of haematology.
2019 06; 185(5):959-961. doi:
10.1111/bjh.15665. [PMID: 30407620] - Prajna Shanbhogue, Reece M Hoffmann, Michael V Airola, Rohan Maini, David J Hamelin, Miguel Garcia-Diaz, John E Burke, Yusuf A Hannun. The juxtamembrane linker in neutral sphingomyelinase-2 functions as an intramolecular allosteric switch that activates the enzyme.
The Journal of biological chemistry.
2019 05; 294(18):7488-7502. doi:
10.1074/jbc.ra118.007288. [PMID: 30890560] - Robert J Charnigo, David Beidler, Denis Rybin, Debra D Pittman, Beesan Tan, Jo Howard, Alan D Michelson, Andrew L Frelinger, Nicholas Clarke. PF-04447943, a Phosphodiesterase 9A Inhibitor, in Stable Sickle Cell Disease Patients: A Phase Ib Randomized, Placebo-Controlled Study.
Clinical and translational science.
2019 03; 12(2):180-188. doi:
10.1111/cts.12604. [PMID: 30597771] - Purnendu Kumar Pathak, Anil Kumar, Bhim Bali Prasad. Functionalized nitrogen doped graphene quantum dots and bimetallic Au/Ag core-shell decorated imprinted polymer for electrochemical sensing of anticancerous hydroxyurea.
Biosensors & bioelectronics.
2019 Feb; 127(?):10-18. doi:
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Scientific reports.
2019 02; 9(1):2041. doi:
10.1038/s41598-019-38823-0. [PMID: 30765825] - Crystal Taylor, Malgorzata Kasztan, Binli Tao, Jennifer S Pollock, David M Pollock. Combined hydroxyurea and ETA receptor blockade reduces renal injury in the humanized sickle cell mouse.
Acta physiologica (Oxford, England).
2019 02; 225(2):e13178. doi:
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Journal of clinical pharmacology.
2019 01; 59(1):98-106. doi:
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Blood purification.
2019; 47(1-3):205-213. doi:
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PloS one.
2019; 14(7):e0218040. doi:
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The Pan African medical journal.
2019; 33(?):253. doi:
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Blood advances.
2018 11; 2(Suppl 1):30-32. doi:
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BMC nephrology.
2018 10; 19(1):256. doi:
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Anti-cancer drugs.
2018 09; 29(8):756-766. doi:
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Blood advances.
2018 08; 2(15):1969-1979. doi:
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British journal of clinical pharmacology.
2018 07; 84(7):1478-1485. doi:
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