Isovaleric acid (BioDeep_00000003398)

 

Secondary id: BioDeep_00000405345, BioDeep_00000861645

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


3-Methylbutyric acid: isopropyl-acetic acid

化学式: C5H10O2 (102.068076)
中文名称: 异戊酸, 异戊酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.12%

分子结构信息

SMILES: CC(C)CC(=O)O
InChI: InChI=1S/C5H10O2/c1-4(2)3-5(6)7/h4H,3H2,1-2H3,(H,6,7)

描述信息

Isovaleric acid, is a natural fatty acid found in a wide variety of plants and essential oils. Isovaleric acid is clear colorless liquid that is sparingly soluble in water, but well soluble in most common organic solvents. It has been suggested that isovaleric acid from pilot whales, a species frequently consumed in the Faroe Islands, may be the unusual dietary factor in prolonged gestation in the population of the Faroe Islands. Previous studies suggested that was due to the high intake of n-3 polyunsaturated fatty acids has been, but fatty acid data for eicosapentaenoic acid (EPA) and docosahexanoic acid (DHA) in blood lipids of Faroese and Norwegians was reviewed in terms of the type of fish eaten (mostly lean white fish with DHA much greater than EPA); the popular lean fish, thus, probably provides too little EPA to produce a marked effect on human biochemistry (PMID 2646392). Isovaleric acid is found to be associated with isovaleric acidemia, which is an inborn error of metabolism.
Flavouring agent. Simple esters are used in flavourings. Constituent of hops, cheese etc.; an important component of cheese aroma and flavour
CONFIDENCE standard compound; INTERNAL_ID 152
KEIO_ID I018
Isovaleric acid is a natural fatty acid and known to effect on neonatal death and possible Jamaican vomiting sickness in human.
Isovaleric acid is a natural fatty acid and known to effect on neonatal death and possible Jamaican vomiting sickness in human.

同义名列表

34 个代谢物同义名

3-Methylbutyric acid: isopropyl-acetic acid; 3-Methylbutyric acid: isopropyl-acetate; β-Methylbutyric acid; 3-Methyl-1-butanoic acid; beta-Methylbutyric acid; 3-Methyl-N-butyric acid; 3-methyl-butanoic acid; 3-Methylbutanoic acid; 3-Methyl butyric acid; β-Methylbutyrate; Isopropylacetic acid; 3-Methylbuttersaeure; Β-methylbutyric acid; 3-Methylbutyric acid; b-Methylbutyric acid; beta-Methylbutyrate; Isobutylformic acid; 3-Methyl-N-butyrate; Isovalerianic acid; Isovaleriansaeure; 3-Methylbutanoate; Isopentanoic acid; Β-methylbutyrate; 3-Methylbutyrate; b-Methylbutyrate; Isopropylacetate; ISOVALERIC ACID; Isobutylformate; Isovalerianate; Delphinic acid; Isopentanoate; Isovalerate; Delphinate; FA 5:0



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(2)

BioCyc(0)

PlantCyc(0)

代谢反应

5 个相关的代谢反应过程信息。

Reactome(2)

  • Olfactory Signaling Pathway: GTP + odorant:Olfactory Receptor:GNAL:GDP:GNB1:GNG13 ⟶ GDP + odorant:Olfactory Receptor:GNAL:GTP:GNB1:GNG13
  • Sensory Perception: GTP + odorant:Olfactory Receptor:GNAL:GDP:GNB1:GNG13 ⟶ GDP + odorant:Olfactory Receptor:GNAL:GTP:GNB1:GNG13

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(3)

PharmGKB(0)

113 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Elisa Schuh, Sina Cassau, Ahmed R Ismaieel, Regina Stieber, Jürgen Krieger, Bill S Hansson, Silke Sachse, Sonja Bisch-Knaden. Females smell differently: characteristics and significance of the most common olfactory sensilla of female silkmoths. Proceedings. Biological sciences. 2024 Jan; 291(2015):20232578. doi: 10.1098/rspb.2023.2578. [PMID: 38228178]
  • Yiming Ni, Liangyin Cai, Xiaojun Gou, Wenjie Li, Mingmei Zhou, Ying Huang. Therapeutic effect of Sanhua decoction on rats with middle cerebral artery occlusion and the associated changes in gut microbiota and short-chain fatty acids. PloS one. 2024; 19(2):e0298148. doi: 10.1371/journal.pone.0298148. [PMID: 38363776]
  • Zuren Li, Haodong Bai, Zhendong Bai, Jincai Han, Dingfeng Luo, Lianyang Bai. Multi-omics analysis identifies EcCS4 is negatively regulated in response to phytotoxin isovaleric acid stress in Echinochloa crus-galli. Pest management science. 2023 Dec; ?(?):. doi: 10.1002/ps.7927. [PMID: 38088480]
  • Hui Li, Lihan Zhang, Rongshuang Huang, Qian Ren, Fan Guo, Min Shi, Letian Yang, Yang Yu, Liang Ma, Ping Fu. [Sichuan Dark Tea-Based Medicated Dietary Formula Improves Obesity-Induced Renal Lipid Metabolism Disorder in Mice by Remodeling Gut Microbiota and Short-Chain Fatty Acid Metabolism]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 2023 Nov; 54(6):1112-1120. doi: 10.12182/20231160208. [PMID: 38162058]
  • Xiao-Na Huang, Chen-Yang Zhu, Yu-Zhen Li, Chun-Hui Jin. [Weidiao-3 Mixture Improves the Clinical Efficacy of Immunotherapy for Advanced Gastric Cancer by Regulating Intestinal Flora]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. 2023 Aug; 45(4):581-590. doi: 10.3881/j.issn.1000-503x.15496. [PMID: 37654138]
  • Krzysztof Kowalski, Bogumiła Szponar, Patrycja Bochen, Paulina Żebrowska-Różańska, Łukasz Łaczmański, Jerzy Samochowiec, Błażej Misiak. Altered levels of fecal short-chain fatty acids are associated with subclinical inflammation and worse cognitive performance in patients with schizophrenia. Journal of psychiatric research. 2023 Jul; 165(?):298-304. doi: 10.1016/j.jpsychires.2023.07.042. [PMID: 37552919]
  • Hao Lin, Qingqing Guo, Zhiyong Wen, Songlin Tan, Jie Chen, Lijian Lin, Pengcheng Chen, Jianquan He, Jianbo Wen, Ye Chen. The multiple effects of fecal microbiota transplantation on diarrhea-predominant irritable bowel syndrome (IBS-D) patients with anxiety and depression behaviors. Microbial cell factories. 2021 Dec; 20(1):233. doi: 10.1186/s12934-021-01720-1. [PMID: 34963452]
  • Lijun Ling, Yunhua Zhao, Yixin Tu, Caiyun Yang, Wenxia Ma, Shenglai Feng, Lu Lu, Ji Zhang. The inhibitory effect of volatile organic compounds produced by Bacillus subtilis CL2 on pathogenic fungi of wolfberry. Journal of basic microbiology. 2021 Feb; 61(2):110-121. doi: 10.1002/jobm.202000522. [PMID: 33368461]
  • Paula Cordero-Pérez, Concepción Sánchez-Martínez, Pedro Alberto García-Hernández, Alma L Saucedo. Metabolomics of the diabetic nephropathy: behind the fingerprint of development and progression indicators. Nefrologia. 2020 Nov; 40(6):585-596. doi: 10.1016/j.nefro.2020.07.002. [PMID: 33036786]
  • Naoki Nanashima, Maiko Kitajima, Shizuka Takamagi, Miyuki Fujioka, Toshiko Tomisawa. Comparison of Chemical Composition between Kuromoji (Lindera umbellata) Essential Oil and Hydrosol and Determination of the Deodorizing Effect. Molecules (Basel, Switzerland). 2020 Sep; 25(18):. doi: 10.3390/molecules25184195. [PMID: 32933154]
  • Dannielle Kowacich, Eduardo Hatano, Coby Schal, Loganathan Ponnusamy, Charles S Apperson, Tatsiana Shymanovich, Gideon Wasserberg. The egg and larval pheromone dodecanoic acid mediates density-dependent oviposition of Phlebotomus papatasi. Parasites & vectors. 2020 Jun; 13(1):280. doi: 10.1186/s13071-020-04151-w. [PMID: 32493498]
  • Jun-Juan Wang, Qi-Min Zhang, Wei-Wei Ni, Xin Zhang, Ying Li, Ai-Li Li, Peng Du, Chun Li, Su-Su Yu. Modulatory effect of Lactobacillus acidophilus KLDS 1.0738 on intestinal short-chain fatty acids metabolism and GPR41/43 expression in β-lactoglobulin-sensitized mice. Microbiology and immunology. 2019 Aug; 63(8):303-315. doi: 10.1111/1348-0421.12723. [PMID: 31218724]
  • Jerzy Żuchowski, Łukasz Pecio, Beata Marciniak, Renata Kontek, Anna Stochmal. Unusual isovalerylated flavonoids from the fruit of sea buckthorn (Elaeagnus rhamnoides) grown in Sokółka, Poland. Phytochemistry. 2019 Jul; 163(?):178-186. doi: 10.1016/j.phytochem.2019.03.001. [PMID: 30952449]
  • O P Brinda, Deepu Mathew, M R Shylaja, P Sangeetha Davis, K Anita Cherian, P A Valsala. Isovaleric acid and avicequinone-C are Chikungunya virus resistance principles in Glycosmis pentaphylla (Retz.) Correa. Journal of vector borne diseases. 2019 Apr; 56(2):111-121. doi: 10.4103/0972-9062.263719. [PMID: 31397386]
  • Rían W Manville, Geoffrey W Abbott. Ancient and modern anticonvulsants act synergistically in a KCNQ potassium channel binding pocket. Nature communications. 2018 09; 9(1):3845. doi: 10.1038/s41467-018-06339-2. [PMID: 30242262]
  • Q Liu, C Wang, G Guo, W J Huo, Y L Zhang, C X Pei, S L Zhang, H Wang. Effects of isovalerate supplements on morphology and functional gene expression of rumen mucosa in pre- and post-weaning dairy calves. Animal : an international journal of animal bioscience. 2018 Mar; 12(3):491-500. doi: 10.1017/s175173111700194x. [PMID: 28766470]
  • Paul M Ryan, Lis E E London, Trent C Bjorndahl, Rupasri Mandal, Kiera Murphy, Gerald F Fitzgerald, Fergus Shanahan, R Paul Ross, David S Wishart, Noel M Caplice, Catherine Stanton. Microbiome and metabolome modifying effects of several cardiovascular disease interventions in apo-E-/- mice. Microbiome. 2017 03; 5(1):30. doi: 10.1186/s40168-017-0246-x. [PMID: 28285599]
  • María L Couce, Luís Aldamiz-Echevarría, María A Bueno, Patricia Barros, Amaya Belanger-Quintana, Javier Blasco, María-Teresa García-Silva, Ana M Márquez-Armenteros, Isidro Vitoria, Inmaculada Vives, Rosa Navarrete, Ana Fernández-Marmiesse, Belén Pérez, Celia Pérez-Cerdá. Genotype and phenotype characterization in a Spanish cohort with isovaleric acidemia. Journal of human genetics. 2017 Mar; 62(3):355-360. doi: 10.1038/jhg.2016.144. [PMID: 27904153]
  • Yu V Holota, O O Holubenko, A M Ostapchuk, T M Serhiychuk, L V Zakordonets, G M Tolstanova. Fecal short-chain fatty acids at different time points after ceftriaxone administration in rats. Ukrainian biochemical journal. 2017 Jan; 89(1):50-8. doi: 10.15407/ubj89.01.050. [PMID: 29236389]
  • Benjamin Kalbe, Marian Schlimm, Sebastian Wojcik, Stathis Philippou, Désirée Maßberg, Fabian Jansen, Paul Scholz, Hermann Luebbert, Burkhard Ubrig, Sabrina Osterloh, Hanns Hatt. Olfactory signaling components and olfactory receptors are expressed in tubule cells of the human kidney. Archives of biochemistry and biophysics. 2016 Nov; 610(?):8-15. doi: 10.1016/j.abb.2016.09.017. [PMID: 27693121]
  • Olga Szczesniak, Knut A Hestad, Jon Fredrik Hanssen, Knut Rudi. Isovaleric acid in stool correlates with human depression. Nutritional neuroscience. 2016 Sep; 19(7):279-83. doi: 10.1179/1476830515y.0000000007. [PMID: 25710209]
  • T Ya Vakhitov, N Chalisova, S I Sitkin. EFFECT OF CARBOXYLIC ACIDS OF GUT MICROBIAL ORIGIN ON HOST CELL PROLIFERATION IN ORGANOTYPIC TISSUE CULTURES. Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology. 2016 Jul; 12(12):73-82. doi: . [PMID: 29889427]
  • Sonia Blasioli, Enrico Biondi, Devasena Samudrala, Francesco Spinelli, Antonio Cellini, Assunta Bertaccini, Simona M Cristescu, Ilaria Braschi. Identification of volatile markers in potato brown rot and ring rot by combined GC-MS and PTR-MS techniques: study on in vitro and in vivo samples. Journal of agricultural and food chemistry. 2014 Jan; 62(2):337-47. doi: 10.1021/jf403436t. [PMID: 24313381]
  • Greta Jakobsdottir, Jens Holst Bjerregaard, Hanne Skovbjerg, Margareta Nyman. Fasting serum concentration of short-chain fatty acids in subjects with microscopic colitis and celiac disease: no difference compared with controls, but between genders. Scandinavian journal of gastroenterology. 2013 Jun; 48(6):696-701. doi: 10.3109/00365521.2013.786128. [PMID: 23600961]
  • Mahmoud A Al-Qudah. Chemical composition and antimicrobial activity of the essential oil of Linum pubescens growing wild in Jordan. Natural product research. 2013; 27(12):1141-4. doi: 10.1080/14786419.2012.715291. [PMID: 22913459]
  • J A Sabbia, K F Kalscheur, A D Garcia, A M Gehman, J M Tricarico. Soybean meal substitution with a yeast-derived microbial protein source in dairy cow diets. Journal of dairy science. 2012 Oct; 95(10):5888-900. doi: 10.3168/jds.2011-5237. [PMID: 22863090]
  • Yong-Soo Seo, Hyang-Nam Bae, Sung-Hwan Eom, Keun-Sick Lim, In-Hye Yun, Yong-Hyun Chung, Jeong-Min Jeon, Hyun-Woo Kim, Myung-Suk Lee, Yang-Bong Lee, Young-Mog Kim. Removal of off-flavors from sea tangle (Laminaria japonica) extract by fermentation with Aspergillus oryzae. Bioresource technology. 2012 Oct; 121(?):475-9. doi: 10.1016/j.biortech.2012.07.007. [PMID: 22840201]
  • B R Min, S Solaiman, N Gurung, J Behrends, J-S Eun, E Taha, J Rose. Effects of pine bark supplementation on performance, rumen fermentation, and carcass characteristics of Kiko crossbred male goats. Journal of animal science. 2012 Oct; 90(10):3556-67. doi: 10.2527/jas.2011-4931. [PMID: 22851241]
  • Gemma E Walton, Congyi Lu, Isabel Trogh, Filip Arnaut, Glenn R Gibson. A randomised, double-blind, placebo controlled cross-over study to determine the gastrointestinal effects of consumption of arabinoxylan-oligosaccharides enriched bread in healthy volunteers. Nutrition journal. 2012 Jun; 11(?):36. doi: 10.1186/1475-2891-11-36. [PMID: 22657950]
  • Liz Girardi Müller, Luisa de Andrade Salles, Satchie Sakamoto, Ana Cristina Stein, Simone Tasca Cargnin, Eduardo Cassel, Rubem Figueiró Vargas, Stela Maris Kuze Rates, Gilsane Lino von Poser. Effect of storage time and conditions on the diene valepotriates content of the extract of Valeriana glechomifolia obtained by supercritical carbon dioxide. Phytochemical analysis : PCA. 2012 May; 23(3):222-7. doi: 10.1002/pca.1346. [PMID: 21953720]
  • Xue Gui Liu, Pin Yi Gao, Guo Sheng Wang, Shao Jiang Song, Ling Zhi Li, Xi Li, Xin Sheng Yao, Zhen Xue Zhang. In vivo antidepressant activity of sesquiterpenes from the roots of Valeriana fauriei Briq. Fitoterapia. 2012 Apr; 83(3):599-603. doi: 10.1016/j.fitote.2012.01.004. [PMID: 22285939]
  • E A French, S J Bertics, L E Armentano. Rumen and milk odd- and branched-chain fatty acid proportions are minimally influenced by ruminal volatile fatty acid infusions. Journal of dairy science. 2012 Apr; 95(4):2015-26. doi: 10.3168/jds.2011-4827. [PMID: 22459847]
  • Alana Pimentel Moura, César Augusto João Ribeiro, Ângela Zanatta, Estela Natacha Brandt Busanello, Anelise Miotti Tonin, Moacir Wajner. 3-Methylcrotonylglycine disrupts mitochondrial energy homeostasis and inhibits synaptic Na(+),K (+)-ATPase activity in brain of young rats. Cellular and molecular neurobiology. 2012 Mar; 32(2):297-307. doi: 10.1007/s10571-011-9761-7. [PMID: 21993987]
  • Michael D Sharp, Nurdan A Kocaoglu-Vurma, Vaughan Langford, Luis E Rodriguez-Saona, W James Harper. Rapid discrimination and characterization of vanilla bean extracts by attenuated total reflection infrared spectroscopy and selected ion flow tube mass spectrometry. Journal of food science. 2012 Mar; 77(3):C284-92. doi: 10.1111/j.1750-3841.2011.02544.x. [PMID: 22384952]
  • K R Kerr, B M Vester Boler, C L Morris, K J Liu, K S Swanson. Apparent total tract energy and macronutrient digestibility and fecal fermentative end-product concentrations of domestic cats fed extruded, raw beef-based, and cooked beef-based diets. Journal of animal science. 2012 Feb; 90(2):515-22. doi: 10.2527/jas.2010-3266. [PMID: 22003235]
  • Jing Xu, Yushan Li, Yuanqiang Guo, Ping Guo, Tohru Yamakuni, Yasushi Ohizumi. Isolation, structural elucidation, and neuroprotective effects of iridoids from Valeriana jatamansi. Bioscience, biotechnology, and biochemistry. 2012; 76(7):1401-3. doi: 10.1271/bbb.120097. [PMID: 22785467]
  • Monika Wroblewska, Jerzy Juskiewicz, Wieslaw Wiczkowski. Physiological properties of beetroot crisps applied in standard and dyslipidaemic diets of rats. Lipids in health and disease. 2011 Oct; 10(?):178. doi: 10.1186/1476-511x-10-178. [PMID: 21995671]
  • Yusei Kashima, Hidehiko Yamaki, Takuya Suzuki, Mitsuo Miyazawa. Insecticidal effect and chemical composition of the volatile oil from Bergenia ligulata. Journal of agricultural and food chemistry. 2011 Jul; 59(13):7114-9. doi: 10.1021/jf201401j. [PMID: 21639116]
  • Ramesh B Potu, Amer A AbuGhazaleh, Darcie Hastings, Karen Jones, Salam A Ibrahim. The effect of lipid supplements on ruminal bacteria in continuous culture fermenters varies with the fatty acid composition. Journal of microbiology (Seoul, Korea). 2011 Apr; 49(2):216-23. doi: 10.1007/s12275-011-0365-1. [PMID: 21538241]
  • Marta Daniotti, Giancarlo la Marca, Patrizio Fiorini, Luca Filippi. New developments in the treatment of hyperammonemia: emerging use of carglumic acid. International journal of general medicine. 2011 Jan; 4(?):21-8. doi: 10.2147/ijgm.s10490. [PMID: 21403788]
  • Rajesh Arora, R Chawla, Rohit Marwah, P Arora, R K Sharma, Vinod Kaushik, R Goel, A Kaur, M Silambarasan, R P Tripathi, J R Bhardwaj. Potential of Complementary and Alternative Medicine in Preventive Management of Novel H1N1 Flu (Swine Flu) Pandemic: Thwarting Potential Disasters in the Bud. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):586506. doi: 10.1155/2011/586506. [PMID: 20976081]
  • T V Thu, Teck Chwen Loh, H L Foo, H Yaakub, M H Bejo. Effects of liquid metabolite combinations produced by Lactobacillus plantarum on growth performance, faeces characteristics, intestinal morphology and diarrhoea incidence in postweaning piglets. Tropical animal health and production. 2011 Jan; 43(1):69-75. doi: 10.1007/s11250-010-9655-6. [PMID: 20632092]
  • Marcia Levin Pelchat, Cathy Bykowski, Fujiko F Duke, Danielle R Reed. Excretion and perception of a characteristic odor in urine after asparagus ingestion: a psychophysical and genetic study. Chemical senses. 2011 Jan; 36(1):9-17. doi: 10.1093/chemse/bjq081. [PMID: 20876394]
  • Qing Shen, Yin An Chen, Kieran M Tuohy. A comparative in vitro investigation into the effects of cooked meats on the human faecal microbiota. Anaerobe. 2010 Dec; 16(6):572-7. doi: 10.1016/j.anaerobe.2010.09.007. [PMID: 20934523]
  • V A Corriher, G M Hill, J K Bernard, T C Jenkins, J W West, B G Mullinix. Pigeon peas as a supplement for lactating dairy cows fed corn silage-based diets. Journal of dairy science. 2010 Nov; 93(11):5309-17. doi: 10.3168/jds.2010-3182. [PMID: 20965347]
  • K A Barry, B J Wojcicki, I S Middelbos, B M Vester, K S Swanson, G C Fahey. Dietary cellulose, fructooligosaccharides, and pectin modify fecal protein catabolites and microbial populations in adult cats. Journal of animal science. 2010 Sep; 88(9):2978-87. doi: 10.2527/jas.2009-2464. [PMID: 20495116]
  • Igor Jerković, Zvonimir Marijanović. Volatile composition screening of Salix spp. nectar honey: benzenecarboxylic acids, norisoprenoids, terpenes, and others. Chemistry & biodiversity. 2010 Sep; 7(9):2309-25. doi: 10.1002/cbdv.201000021. [PMID: 20860033]
  • Tomás Rezanka, Ales Prell, Jaroslav Spízek, Karel Sigler. Pilot-plant cultivation of Streptomyces griseus producing homologues of nonactin by precursor-directed biosynthesis and their identification by LC/MS-ESI. The Journal of antibiotics. 2010 Aug; 63(8):524-9. doi: 10.1038/ja.2010.93. [PMID: 20664602]
  • Robin F Benus, Hermie J Harmsen, Gjalt W Welling, Rob Spanjersberg, Jan G Zijlstra, John E Degener, Tjip S van der Werf. Impact of digestive and oropharyngeal decontamination on the intestinal microbiota in ICU patients. Intensive care medicine. 2010 Aug; 36(8):1394-402. doi: 10.1007/s00134-010-1826-4. [PMID: 20232045]
  • Federico E Rey, Jeremiah J Faith, James Bain, Michael J Muehlbauer, Robert D Stevens, Christopher B Newgard, Jeffrey I Gordon. Dissecting the in vivo metabolic potential of two human gut acetogens. The Journal of biological chemistry. 2010 Jul; 285(29):22082-90. doi: 10.1074/jbc.m110.117713. [PMID: 20444704]
  • Yuhao Ren, Gary Strobel, Joe Sears, Melina Park. Geobacillus sp., a thermophilic soil bacterium producing volatile antibiotics. Microbial ecology. 2010 Jul; 60(1):130-6. doi: 10.1007/s00248-009-9630-9. [PMID: 20091406]
  • Mohamed A Ibrahim, Maarit Mäenpää, Viivi Hassinen, Sari Kontunen-Soppela, Lukás Malec, Matti Rousi, Liisa Pietikäinen, Arja Tervahauta, Sirpa Kärenlampi, Jarmo K Holopainen, Elina J Oksanen. Elevation of night-time temperature increases terpenoid emissions from Betula pendula and Populus tremula. Journal of experimental botany. 2010 Jun; 61(6):1583-95. doi: 10.1093/jxb/erq034. [PMID: 20181662]
  • Anthony Schilmiller, Feng Shi, Jeongwoon Kim, Amanda L Charbonneau, Daniel Holmes, A Daniel Jones, Robert L Last. Mass spectrometry screening reveals widespread diversity in trichome specialized metabolites of tomato chromosomal substitution lines. The Plant journal : for cell and molecular biology. 2010 May; 62(3):391-403. doi: 10.1111/j.1365-313x.2010.04154.x. [PMID: 20113441]
  • Susan C Connor, Michael K Hansen, Adam Corner, Randall F Smith, Terence E Ryan. Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes. Molecular bioSystems. 2010 May; 6(5):909-21. doi: 10.1039/b914182k. [PMID: 20567778]
  • P E Urriola, H H Stein. Effects of distillers dried grains with solubles on amino acid, energy, and fiber digestibility and on hindgut fermentation of dietary fiber in a corn-soybean meal diet fed to growing pigs. Journal of animal science. 2010 Apr; 88(4):1454-62. doi: 10.2527/jas.2009-2162. [PMID: 20023135]
  • E Molina-Alcaide, A I Martín-García, A Moumen, M D Carro. Ruminal fermentation, microbial growth and amino acid flow in single-flow continuous culture fermenters fed a diet containing olive leaves. Journal of animal physiology and animal nutrition. 2010 Apr; 94(2):227-36. doi: 10.1111/j.1439-0396.2008.00905.x. [PMID: 19175451]
  • Carla C C R de Carvalho, Pedro Fernandes. Production of metabolites as bacterial responses to the marine environment. Marine drugs. 2010 Mar; 8(3):705-27. doi: 10.3390/md8030705. [PMID: 20411122]
  • J Cameron Thrash, Jarrod Pollock, Tamas Torok, John D Coates. Description of the novel perchlorate-reducing bacteria Dechlorobacter hydrogenophilus gen. nov., sp. nov.and Propionivibrio militaris, sp. nov. Applied microbiology and biotechnology. 2010 Mar; 86(1):335-43. doi: 10.1007/s00253-009-2336-6. [PMID: 19921177]
  • Bungo Shirouchi, Koji Nagao, Kenta Furuya, Toshiharu Nagai, Kenji Ichioka, Shigeru Tokairin, Yasuhiro Iida, Teruyoshi Yanagita. Physiological functions of iso-type short-chain fatty acid and omega 3 polyunsaturated fatty acids containing oil in obese OLETF rats. Journal of oleo science. 2010; 59(6):299-305. doi: 10.5650/jos.59.299. [PMID: 20484835]
  • M L May, M J Quinn, C D Reinhardt, L Murray, M L Gibson, K K Karges, J S Drouillard. Effects of dry-rolled or steam-flaked corn finishing diets with or without twenty-five percent dried distillers grains on ruminal fermentation and apparent total tract digestion. Journal of animal science. 2009 Nov; 87(11):3630-8. doi: 10.2527/jas.2008-0857. [PMID: 19648506]
  • Katharina Breme, Pascal Tournayre, Xavier Fernandez, Uwe J Meierhenrich, Hugues Brevard, Daniel Joulain, Jean Louis Berdagué. Identification of odor impact compounds of Tagetes minuta L. essential oil: comparison of two GC-olfactometry methods. Journal of agricultural and food chemistry. 2009 Sep; 57(18):8572-80. doi: 10.1021/jf9016509. [PMID: 19694437]
  • Y-H Chung, C M Martinez, N E Brown, T W Cassidy, G A Varga. Ruminal and blood responses to propylene glycol during frequent feeding. Journal of dairy science. 2009 Sep; 92(9):4555-64. doi: 10.3168/jds.2009-2131. [PMID: 19700718]
  • Jonas M Bengtsson, Yitbarek Wolde-Hawariat, Hamida Khbaish, Merid Negash, Bekele Jembere, Emiru Seyoum, Bill S Hansson, Mattias C Larsson, Ylva Hillbur. Field attractants for Pachnoda interrupta selected by means of GC-EAD and single sensillum screening. Journal of chemical ecology. 2009 Sep; 35(9):1063-76. doi: 10.1007/s10886-009-9684-7. [PMID: 19768509]
  • M J Spiehs, V H Varel. Nutrient excretion and odorant production in manure from cattle fed corn wet distillers grains with solubles. Journal of animal science. 2009 Sep; 87(9):2977-84. doi: 10.2527/jas.2008-1584. [PMID: 19502500]
  • I Ntaikou, C Kourmentza, E C Koutrouli, K Stamatelatou, A Zampraka, M Kornaros, G Lyberatos. Exploitation of olive oil mill wastewater for combined biohydrogen and biopolymers production. Bioresource technology. 2009 Aug; 100(15):3724-30. doi: 10.1016/j.biortech.2008.12.001. [PMID: 19138844]
  • Donovan P German. Do herbivorous minnows have 'plug-flow reactor' guts? Evidence from digestive enzyme activities, gastrointestinal fermentation, and luminal nutrient concentrations. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. 2009 Aug; 179(6):759-71. doi: 10.1007/s00360-009-0359-z. [PMID: 19363616]
  • Zoey P Zahorodny Duggan, Heather N Koopman, Suzanne M Budge. Distribution and development of the highly specialized lipids in the sound reception systems of dolphins. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. 2009 Aug; 179(6):783-98. doi: 10.1007/s00360-009-0360-6. [PMID: 19373476]
  • D T Loots. Abnormal tricarboxylic acid cycle metabolites in isovaleric acidaemia. Journal of inherited metabolic disease. 2009 Jun; 32(3):403-11. doi: 10.1007/s10545-009-1071-6. [PMID: 19343532]
  • Yun Weng, Tienyi Theresa Hsu, Jing Zhao, Stefanie Nishimura, Gerald G Fuller, James M Sonner. Isovaleric, methylmalonic, and propionic acid decrease anesthetic EC50 in tadpoles, modulate glycine receptor function, and interact with the lipid 1,2-dipalmitoyl-Sn-glycero-3-phosphocholine. Anesthesia and analgesia. 2009 May; 108(5):1538-45. doi: 10.1213/ane.0b013e31819cd964. [PMID: 19372333]
  • Nora A Foroud, François Eudes. Trichothecenes in cereal grains. International journal of molecular sciences. 2009 Jan; 10(1):147-173. doi: 10.3390/ijms10010147. [PMID: 19333439]
  • T Atsumi, K Tonosaki, S Fujisawa. Salivary free radical-scavenging activity is affected by physical and mental activities. Oral diseases. 2008 Sep; 14(6):490-6. doi: 10.1111/j.1601-0825.2007.01406.x. [PMID: 18826379]
  • U Nilsson, M Johansson, A Nilsson, I Björck, M Nyman. Dietary supplementation with beta-glucan enriched oat bran increases faecal concentration of carboxylic acids in healthy subjects. European journal of clinical nutrition. 2008 Aug; 62(8):978-84. doi: 10.1038/sj.ejcn.1602816. [PMID: 17522598]
  • Alexandre F Solano, Guilhian Leipnitz, Giorgia M De Bortoli, Bianca Seminotti, Alexandre U Amaral, Carolina G Fernandes, Alexandra S Latini, Carlos S Dutra-Filho, Moacir Wajner. Induction of oxidative stress by the metabolites accumulating in isovaleric acidemia in brain cortex of young rats. Free radical research. 2008 Aug; 42(8):707-15. doi: 10.1080/10715760802311179. [PMID: 18661426]
  • Doris M Jacobs, Nancy Deltimple, Ewoud van Velzen, Ferdi A van Dorsten, Max Bingham, Elaine E Vaughan, John van Duynhoven. (1)H NMR metabolite profiling of feces as a tool to assess the impact of nutrition on the human microbiome. NMR in biomedicine. 2008 Jul; 21(6):615-26. doi: 10.1002/nbm.1233. [PMID: 18085514]
  • Gary A Strobel, Shanney Spang, Katreena Kluck, W M Hess, Joe Sears, Tom Livinghouse. Synergism among volatile organic compounds resulting in increased antibiosis in Oidium sp. FEMS microbiology letters. 2008 Jun; 283(2):140-5. doi: 10.1111/j.1574-6968.2008.01137.x. [PMID: 18422630]
  • C M Westermann, L Dorland, D M Votion, M G M de Sain-van der Velden, I D Wijnberg, R J A Wanders, W G M Spliet, N Testerink, R Berger, J P N Ruiter, J H van der Kolk. Acquired multiple Acyl-CoA dehydrogenase deficiency in 10 horses with atypical myopathy. Neuromuscular disorders : NMD. 2008 May; 18(5):355-64. doi: 10.1016/j.nmd.2008.02.007. [PMID: 18406615]
  • Martin Heil, Ulrich Lion, Wilhelm Boland. Defense-inducing volatiles: in search of the active motif. Journal of chemical ecology. 2008 May; 34(5):601-4. doi: 10.1007/s10886-008-9464-9. [PMID: 18408973]
  • Jyunichi Kawata, Munekazu Kameda, Mitsuo Miyazawa. Cyclooxygenase-2 inhibitory effects and composition of the volatile oil from the dried roots of Lithospermum erythrorhizon. Journal of natural medicines. 2008 Apr; 62(2):239-43. doi: 10.1007/s11418-007-0221-0. [PMID: 18404332]
  • G Getachew, W Pittroff, E J Depeters, D H Putnam, A Dandekar, S Goyal. Influence of tannic acid application on alfalfa hay: in vitro rumen fermentation, serum metabolites and nitrogen balance in sheep. Animal : an international journal of animal bioscience. 2008 Mar; 2(3):381-90. doi: 10.1017/s1751731107001486. [PMID: 22445040]
  • Asghar Safaralie, Shohreh Fatemi, Fatemeh Sefidkon. Essential oil composition of Valeriana officinalis L. roots cultivated in Iran. Comparative analysis between supercritical CO2 extraction and hydrodistillation. Journal of chromatography. A. 2008 Feb; 1180(1-2):159-64. doi: 10.1016/j.chroma.2007.12.011. [PMID: 18164718]
  • Premsiri Rotsatchakul, Siree Chaiseri, Keith R Cadwallader. Identification of characteristic aroma components of Thai fried chili paste. Journal of agricultural and food chemistry. 2008 Jan; 56(2):528-36. doi: 10.1021/jf072499n. [PMID: 18163558]
  • Francois-Pierre J Martin, Yulan Wang, Norbert Sprenger, Ivan K S Yap, Torbjörn Lundstedt, Per Lek, Serge Rezzi, Ziad Ramadan, Peter van Bladeren, Laurent B Fay, Sunil Kochhar, John C Lindon, Elaine Holmes, Jeremy K Nicholson. Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model. Molecular systems biology. 2008; 4(?):157. doi: 10.1038/msb4100190. [PMID: 18197175]
  • H Song, K R Cadwallader. Aroma components of American country ham. Journal of food science. 2008 Jan; 73(1):C29-35. doi: 10.1111/j.1750-3841.2007.00593.x. [PMID: 18211346]
  • Dominika Bal, Anna Kraska-Dziadecka, Wanda Gradowska, Adam Gryff-Keller. Investigation of a wide spectrum of inherited metabolic disorders by 13C NMR spectroscopy. Acta biochimica Polonica. 2008; 55(1):107-18. doi: 10.18388/abp.2008_3103. [PMID: 18217108]
  • Francois-Pierre J Martin, Yulan Wang, Norbert Sprenger, Ivan K S Yap, Serge Rezzi, Ziad Ramadan, Emma Peré-Trepat, Florence Rochat, Christine Cherbut, Peter van Bladeren, Laurent B Fay, Sunil Kochhar, John C Lindon, Elaine Holmes, Jeremy K Nicholson. Top-down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model. Molecular systems biology. 2008; 4(?):205. doi: 10.1038/msb.2008.40. [PMID: 18628745]
  • J K Htoo, B A Araiza, W C Sauer, M Rademacher, Y Zhang, M Cervantes, R T Zijlstra. Effect of dietary protein content on ileal amino acid digestibility, growth performance, and formation of microbial metabolites in ileal and cecal digesta of early-weaned pigs. Journal of animal science. 2007 Dec; 85(12):3303-12. doi: 10.2527/jas.2007-0105. [PMID: 17785591]
  • Luigi Battaglia, Michele Trotta, Marina Gallarate, M Eugenia Carlotti, Gian Paolo Zara, Alessandro Bargoni. Solid lipid nanoparticles formed by solvent-in-water emulsion-diffusion technique: development and influence on insulin stability. Journal of microencapsulation. 2007 Nov; 24(7):660-72. doi: 10.1080/02652040701532981. [PMID: 17763060]
  • D T Loots, L J Mienie, E Erasmus. Amino-acid depletion induced by abnormal amino-acid conjugation and protein restriction in isovaleric acidemia. European journal of clinical nutrition. 2007 Nov; 61(11):1323-7. doi: 10.1038/sj.ejcn.1602648. [PMID: 17299485]
  • Gregory Kaler, David M Truong, Akash Khandelwal, Megha Nagle, Satish A Eraly, Peter W Swaan, Sanjay K Nigam. Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. The Journal of biological chemistry. 2007 Aug; 282(33):23841-53. doi: 10.1074/jbc.m703467200. [PMID: 17553798]
  • Tang-Chia Chung, Mei-Chyn Chao, Hsin-Lung Wu. A sensitive liquid chromatographic method for the analysis of isovaleric and valeric acids in urine as fluorescent derivatives. Journal of chromatography. A. 2007 Jul; 1156(1-2):259-63. doi: 10.1016/j.chroma.2007.03.009. [PMID: 17374376]
  • César A J Ribeiro, Fabrício Balestro, Vanessa Grando, Moacir Wajner. Isovaleric acid reduces Na+, K+-ATPase activity in synaptic membranes from cerebral cortex of young rats. Cellular and molecular neurobiology. 2007 Jun; 27(4):529-40. doi: 10.1007/s10571-007-9143-3. [PMID: 17394058]
  • K D Dunkley, C S Dunkley, N L Njongmeta, T R Callaway, M E Hume, L F Kubena, D J Nisbet, S C Ricke. Comparison of in vitro fermentation and molecular microbial profiles of high-fiber feed substrates incubated with chicken cecal inocula. Poultry science. 2007 May; 86(5):801-10. doi: 10.1093/ps/86.5.801. [PMID: 17435012]
  • Shong Ji Piao, Takamitsu Tsukahara, Mitsugi Itoh, Akira Shiga, Yoshikazu Adachi, Kazunari Ushida. The organic acid profiles in the feces of pigs at Brachyspira hyodysenteriae- or B. pilosicoli-positive farms. The Journal of veterinary medical science. 2007 Apr; 69(4):425-8. doi: 10.1292/jvms.69.425. [PMID: 17485934]
  • Katie M Queenan, Maria L Stewart, Kristen N Smith, William Thomas, R Gary Fulcher, Joanne L Slavin. Concentrated oat beta-glucan, a fermentable fiber, lowers serum cholesterol in hypercholesterolemic adults in a randomized controlled trial. Nutrition journal. 2007 Mar; 6(?):6. doi: 10.1186/1475-2891-6-6. [PMID: 17386092]
  • G Ferreira, W P Weiss, L B Willett. Changes in measures of biotin status do not reflect milk yield responses when dairy cows are fed supplemental biotin. Journal of dairy science. 2007 Mar; 90(3):1452-9. doi: 10.3168/jds.s0022-0302(07)71630-2. [PMID: 17297118]
  • Guohua Zhao, Jing-Fu Liu, Margareta Nyman, Jan Ake Jönsson. Determination of short-chain fatty acids in serum by hollow fiber supported liquid membrane extraction coupled with gas chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Feb; 846(1-2):202-8. doi: 10.1016/j.jchromb.2006.09.027. [PMID: 17070116]
  • John R Pluske, Lucile Montagne, Fiona S Cavaney, Bruce P Mullan, David W Pethick, David J Hampson. Feeding different types of cooked white rice to piglets after weaning influences starch digestion, digesta and fermentation characteristics and the faecal shedding of beta-haemolytic Escherichia coli. The British journal of nutrition. 2007 Feb; 97(2):298-306. doi: 10.1017/s0007114507332534. [PMID: 17298698]
  • François-Pierre J Martin, Marc-Emmanuel Dumas, Yulan Wang, Cristina Legido-Quigley, Ivan K S Yap, Huiru Tang, Séverine Zirah, Gerard M Murphy, Olivier Cloarec, John C Lindon, Norbert Sprenger, Laurent B Fay, Sunil Kochhar, Peter van Bladeren, Elaine Holmes, Jeremy K Nicholson. A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model. Molecular systems biology. 2007; 3(?):112. doi: 10.1038/msb4100153. [PMID: 17515922]
  • Gregory Kaler, David M Truong, Derina E Sweeney, Darren W Logan, Megha Nagle, Wei Wu, Satish A Eraly, Sanjay K Nigam. Olfactory mucosa-expressed organic anion transporter, Oat6, manifests high affinity interactions with odorant organic anions. Biochemical and biophysical research communications. 2006 Dec; 351(4):872-6. doi: 10.1016/j.bbrc.2006.10.136. [PMID: 17094945]