Piperine (BioDeep_00000298279)

Secondary id: BioDeep_00000420892

natural product PANOMIX_OTCML-2023

代谢物信息卡片

Isopiperine

化学式: C17H19NO3 (285.1365)
中文名称: 胡椒碱, 胡椒脂碱
谱图信息: 最多检出来源 Homo sapiens(blood) 38.1%

分子结构信息

SMILES: C1CCN(CC1)C(=O)/C=C/C=C/c1ccc2c(c1)OCO2
InChI: InChI=1S/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2

描述信息

Constituent of pepper (Piper nigrum) (Piperaceae). Isopiperine is found in herbs and spices and pepper (spice).
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
Origin: Plant; SubCategory_DNP: Alkaloids derived from lysine, Piperidine alkaloids
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors
Annotation level-1
MS2 deconvoluted using MS2Dec from all ion fragmentation data, MetaboLights identifier MTBLS1040; MXXWOMGUGJBKIW-YPCIICBESA-N_STSL_0203_Piperine_0031fmol_180831_S2_L02M02_45; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
MS2 deconvoluted using CorrDec from all ion fragmentation data, MetaboLights identifier MTBLS1040; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.245
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.243
Piperine, a natural alkaloid isolated from Piper nigrum L, inhibits P-glycoprotein and CYP3A4 activities with an IC50 value of 61.94±0.054 μg/mL in HeLa cell.
Piperine, a natural alkaloid isolated from Piper nigrum L, inhibits P-glycoprotein and CYP3A4 activities with an IC50 value of 61.94±0.054 μg/mL in HeLa cell.

同义名列表

7 个代谢物同义名

Isopiperine; Piperine; chavicine; Bioperine; 1-Piperoylpiperidine; Piperine; Piperine

数据库引用编号

87 个数据库交叉引用编号

ChEBI: CHEBI:93043
ChEBI: CHEBI:28821
KEGG: C03882
PubChem: 638024
PubChem: 4840
DrugBank: DB12582
ChEMBL: CHEMBL43185
foodb: FDB000452
CAS: 94-62-2
CAS: 147030-08-8
CAS: 7780-20-3
CAS: 495-91-0
MoNA: Bruker_HCD_library001476
MoNA: CCMSLIB00005720175
MoNA: VF-NPL-QTOF009336
MoNA: VF-NPL-QTOF009335
MoNA: VF-NPL-QTOF009334
MoNA: NGA02816
MoNA: NGA02815
MoNA: NGA02814
MoNA: NGA02813
MoNA: CB000031
MoNA: PR310562
MoNA: MoNA009986
MoNA: MoNA009985
MoNA: MoNA009984
MoNA: MoNA009983
MoNA: MoNA009982
MoNA: MoNA009981
MoNA: RIKENPlaSMA001810
MoNA: RIKENPlaSMA001807
MoNA: RIKENPlaSMA001804
MoNA: RIKENPlaSMA001801
MoNA: RIKENPlaSMA001798
MoNA: RIKENPlaSMA001795
MoNA: RIKENPlaSMA001792
MoNA: RIKENPlaSMA001790
MoNA: RIKENPlaSMA001787
MoNA: RIKENPlaSMA001784
MoNA: RIKENPlaSMA001781
MoNA: RIKENPlaSMA001779
MoNA: VF-NPL-LTQ007734
MoNA: VF-NPL-LTQ007733
MoNA: VF-NPL-LTQ000302
MoNA: VF-NPL-LTQ000301
MoNA: VF-NPL-LTQ000300
MoNA: VF-NPL-LTQ000299
MoNA: VF-NPL-QEHF028035
MoNA: VF-NPL-QEHF028034
MoNA: VF-NPL-QEHF028033
MoNA: VF-NPL-QEHF028032
MoNA: VF-NPL-QEHF028031
MoNA: VF-NPL-QEHF028030
MoNA: VF-NPL-QEHF028029
MoNA: VF-NPL-QEHF028028
MoNA: VF-NPL-QEHF028027
MoNA: VF-NPL-QEHF028026
MoNA: VF-NPL-QEHF028025
MoNA: VF-NPL-QEHF028024
MoNA: VF-NPL-QEHF028023
MoNA: VF-NPL-QEHF028022
MoNA: VF-NPL-QEHF028021
MoNA: VF-NPL-QEHF000639
MoNA: VF-NPL-QEHF000638
MoNA: VF-NPL-QEHF000637
MoNA: VF-NPL-QEHF000636
MoNA: VF-NPL-QEHF000635
MoNA: VF-NPL-QEHF000634
MoNA: FiehnHILIC002264
MoNA: FiehnHILIC000698
MoNA: BML81977
MoNA: BML81975
MoNA: BML01671
MoNA: BML01660
MoNA: BML01649
PMhub: MS000059427
PubChem: 6615
KNApSAcK: C00002065
PDB-CCD: AYR
3DMET: B00649
NIKKAJI: J4.701E
RefMet: Piperine
medchemexpress: HY-N0144
KNApSAcK: 28821
LOTUS: LTS0014461
LOTUS: LTS0038631
wikidata: Q27294941

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

212 个相关的物种来源信息

201006 - Aglaia: LTS0014461
306512 - Aglaia perviridis: 10.1080/10286020903565226
306512 - Aglaia perviridis: LTS0014461
5598 - Alternaria: LTS0014461
119947 - Alternaria sect. Ulocladium: 10.1016/0031-9422(88)80168-7
119947 - Alternaria sect. Ulocladium: LTS0014461
4890 - Ascomycota: LTS0014461
4210 - Asteraceae: LTS0014461
4071 - Capsicum: LTS0014461
4072 - Capsicum annuum: 10.1016/S0021-9673(01)89200-1
4072 - Capsicum annuum: LTS0014461
41503 - Centaurea: LTS0014461
147541 - Dothideomycetes: LTS0014461
2759 - Eukaryota: LTS0014461
4751 - Fungi: LTS0014461
130372 - Macropiper:
130372 - Macropiper: 10.1016/J.CHROMA.2004.03.056
130372 - Macropiper: 10.1016/S0031-9422(00)00226-0
130372 - Macropiper: 10.1021/JF00103A029
130372 - Macropiper: 10.1055/S-0035-1546106
130372 - Macropiper: 10.3390/MOLECULES15042398
130372 - Macropiper: LTS0014461
3398 - Magnoliopsida: LTS0014461
43707 - Meliaceae: LTS0014461
97971 - Periconia: 10.1038/JA.2011.27
97971 - Periconia: LTS0014461
1898439 - Periconiaceae: LTS0014461
13215 - Piper: 10.1002/JBT.20251
13215 - Piper: 10.1007/S13277-013-1433-4
13215 - Piper: 10.1016/J.CHROMA.2004.03.056
13215 - Piper: 10.1016/J.EJPHAR.2015.01.038
13215 - Piper: 10.1016/J.FCT.2008.06.014
13215 - Piper: 10.1016/J.INTIMP.2004.08.005
13215 - Piper: 10.1016/S0031-9422(00)00226-0
13215 - Piper: 10.1016/S0031-9422(98)00208-8
13215 - Piper: 10.1021/JF00103A029
13215 - Piper: 10.1038/JA.2011.27
13215 - Piper: 10.1055/S-0035-1546106
13215 - Piper: 10.1055/S-1999-14031
13215 - Piper: 10.3390/MOLECULES15042398
13215 - Piper: LTS0014461
538233 - Piper attenuatum: 10.1016/0031-9422(74)80272-4
538233 - Piper attenuatum: LTS0014461
13217 - Piper betle: 10.1002/JBT.20251
13217 - Piper betle: 10.1007/S13277-013-1433-4
13217 - Piper betle: 10.1016/J.EJPHAR.2015.01.038
13217 - Piper betle: 10.1016/J.FCT.2008.06.014
13217 - Piper betle: 10.1016/J.INTIMP.2004.08.005
13217 - Piper betle: 10.1016/S0031-9422(00)00226-0
13217 - Piper betle: 10.1016/S0031-9422(98)00208-8
13217 - Piper betle: 10.1038/JA.2011.27
13217 - Piper betle: 10.1055/S-1999-14031
13217 - Piper betle: LTS0014461
130389 - Piper boehmeriifolium: 10.1002/JPS.2600630733
130389 - Piper boehmeriifolium: LTS0014461
247681 - Piper capense: 10.3390/MOLECULES14093833
247681 - Piper capense: LTS0014461
405322 - Piper cubeba: 10.1002/BIO.1209
405322 - Piper cubeba: LTS0014461
511543 - Piper guineense:
511543 - Piper guineense: 10.1002/CHIN.200340213
511543 - Piper guineense: 10.1002/JBT.20251
511543 - Piper guineense: 10.1007/S13277-013-1433-4
511543 - Piper guineense: 10.1016/J.EJPHAR.2015.01.038
511543 - Piper guineense: 10.1016/J.FCT.2008.06.014
511543 - Piper guineense: 10.1016/J.INTIMP.2004.08.005
511543 - Piper guineense: 10.1016/S0031-9422(00)00226-0
511543 - Piper guineense: 10.1016/S0031-9422(00)94460-1
511543 - Piper guineense: 10.1021/NP030475E
511543 - Piper guineense: 10.1038/JA.2011.27
511543 - Piper guineense: 10.1039/P19740002195
511543 - Piper guineense: 10.1055/S-1999-14031
511543 - Piper guineense: LTS0014461
405331 - Piper khasianum: 10.1016/S0031-9422(98)00208-8
405331 - Piper khasianum: LTS0014461
49511 - Piper longum:
49511 - Piper longum: 10.1002/CHIN.200552178
49511 - Piper longum: 10.1002/JBT.20251
49511 - Piper longum: 10.1007/S11010-005-3702-Z
49511 - Piper longum: 10.1007/S13277-013-1433-4
49511 - Piper longum: 10.1016/J.CHROMA.2004.03.056
49511 - Piper longum: 10.1016/J.EJPHAR.2015.01.038
49511 - Piper longum: 10.1016/J.FCT.2008.06.014
49511 - Piper longum: 10.1016/J.FITOTE.2012.12.001
49511 - Piper longum: 10.1016/J.INTIMP.2004.08.005
49511 - Piper longum: 10.1016/J.PHYMED.2007.06.011
49511 - Piper longum: 10.1016/S0031-9422(00)00226-0
49511 - Piper longum: 10.1021/JF00103A029
49511 - Piper longum: 10.1021/NP030475E
49511 - Piper longum: 10.1038/JA.2011.27
49511 - Piper longum: 10.1055/S-0035-1546106
49511 - Piper longum: 10.1055/S-1999-14031
49511 - Piper longum: 10.1055/S-2006-957982
49511 - Piper longum: 10.1076/PHBI.39.3.236.5926
49511 - Piper longum: 10.1080/10286020.2010.546789
49511 - Piper longum: 10.1248/CPB.31.3562
49511 - Piper longum: 10.1248/CPB.53.832
49511 - Piper longum: 10.3109/13880209.2014.991835
49511 - Piper longum: 10.3390/MOLECULES15042398
49511 - Piper longum: LTS0014461
49511 - Piper longum L.: -
13216 - Piper nigrum:
13216 - Piper nigrum: 10.1002/CHIN.200352219
13216 - Piper nigrum: 10.1002/JBT.20251
13216 - Piper nigrum: 10.1007/BF02856625
13216 - Piper nigrum: 10.1007/S13277-013-1433-4
13216 - Piper nigrum: 10.1016/0031-9422(88)80249-8
13216 - Piper nigrum: 10.1016/0031-9422(90)85102-L
13216 - Piper nigrum: 10.1016/J.BMCL.2012.09.056
13216 - Piper nigrum: 10.1016/J.EJMECH.2010.04.033
13216 - Piper nigrum: 10.1016/J.EJPHAR.2015.01.038
13216 - Piper nigrum: 10.1016/J.FCT.2008.06.014
13216 - Piper nigrum: 10.1016/J.INTIMP.2004.08.005
13216 - Piper nigrum: 10.1016/S0021-9673(01)83545-7
13216 - Piper nigrum: 10.1016/S0021-9673(01)95038-1
13216 - Piper nigrum: 10.1016/S0031-9422(00)00226-0
13216 - Piper nigrum: 10.1016/S0031-9422(97)00202-1
13216 - Piper nigrum: 10.1016/S0968-0896(02)00130-X
13216 - Piper nigrum: 10.1021/ED070P598
13216 - Piper nigrum: 10.1021/IE010359B
13216 - Piper nigrum: 10.1021/IE0107845
13216 - Piper nigrum: 10.1021/JF60178A026
13216 - Piper nigrum: 10.1021/NP030475E
13216 - Piper nigrum: 10.1021/NP030475E.S001
13216 - Piper nigrum: 10.1021/NP900656G
13216 - Piper nigrum: 10.1038/JA.2011.27
13216 - Piper nigrum: 10.1055/S-1999-14031
13216 - Piper nigrum: 10.1055/S-2001-11505
13216 - Piper nigrum: 10.1080/00021369.1981.10864708
13216 - Piper nigrum: 10.1080/14786410310001608028
13216 - Piper nigrum: 10.1080/14786410902757998
13216 - Piper nigrum: 10.1177/1934578X0600100101
13216 - Piper nigrum: 10.1248/BPB.31.1063
13216 - Piper nigrum: 10.1248/CPB.36.2452
13216 - Piper nigrum: 10.1248/CPB.45.685
13216 - Piper nigrum: 10.1271/BBB1961.45.1257
13216 - Piper nigrum: 10.1590/S0103-50532010001000003
13216 - Piper nigrum: 10.17660/ACTAHORTIC.1996.426.21
13216 - Piper nigrum: 10.3390/MOLECULES15042398
13216 - Piper nigrum: 10.3987/COM-02-9518
13216 - Piper nigrum: LTS0014461
1546314 - Piper pedicellatum: 10.1002/CHIN.200447158
1546314 - Piper pedicellatum: LTS0014461
1595994 - Piper peepuloides: LTS0014461
130414 - Piper retrofractum:
130414 - Piper retrofractum: 10.1002/CHIN.199246266
130414 - Piper retrofractum: 10.1002/JBT.20251
130414 - Piper retrofractum: 10.1007/S13277-013-1433-4
130414 - Piper retrofractum: 10.1016/0031-9422(92)83736-I
130414 - Piper retrofractum: 10.1016/J.EJPHAR.2015.01.038
130414 - Piper retrofractum: 10.1016/J.FCT.2008.06.014
130414 - Piper retrofractum: 10.1016/J.INTIMP.2004.08.005
130414 - Piper retrofractum: 10.1016/S0031-9422(00)00226-0
130414 - Piper retrofractum: 10.1016/S0031-9422(00)86838-7
130414 - Piper retrofractum: 10.1016/S0031-9422(01)00364-8
130414 - Piper retrofractum: 10.1038/JA.2011.27
130414 - Piper retrofractum: 10.1055/S-1999-14031
130414 - Piper retrofractum: 10.1055/S-2002-34410
130414 - Piper retrofractum: 10.1271/BBB.57.1329
130414 - Piper retrofractum: LTS0014461
405344 - Piper swartzianum:
405344 - Piper swartzianum: 10.1002/JBT.20251
405344 - Piper swartzianum: 10.1007/S00044-008-9161-9
405344 - Piper swartzianum: 10.1007/S13277-013-1433-4
405344 - Piper swartzianum: 10.1016/J.BMC.2010.03.013
405344 - Piper swartzianum: 10.1016/J.EJPHAR.2015.01.038
405344 - Piper swartzianum: 10.1016/J.FCT.2008.06.014
405344 - Piper swartzianum: 10.1016/J.INTIMP.2004.08.005
405344 - Piper swartzianum: 10.1016/S0031-9422(00)00226-0
405344 - Piper swartzianum: 10.1038/JA.2011.27
405344 - Piper swartzianum: 10.1055/S-1999-14031
405344 - Piper swartzianum: LTS0014461
405345 - Piper sylvaticum: 10.1002/JPS.2600630733
405345 - Piper sylvaticum: LTS0014461
405346 - Piper thomsonii: 10.1002/JBT.20251
405346 - Piper thomsonii: 10.1007/S13277-013-1433-4
405346 - Piper thomsonii: 10.1016/J.EJPHAR.2015.01.038
405346 - Piper thomsonii: 10.1016/J.FCT.2008.06.014
405346 - Piper thomsonii: 10.1016/J.INTIMP.2004.08.005
405346 - Piper thomsonii: 10.1016/S0031-9422(00)00226-0
405346 - Piper thomsonii: 10.1016/S0031-9422(98)00208-8
405346 - Piper thomsonii: 10.1038/JA.2011.27
405346 - Piper thomsonii: 10.1055/S-1999-14031
405346 - Piper thomsonii: LTS0014461
1595995 - Piper trichostachyon: 10.1002/JBT.20251
1595995 - Piper trichostachyon: 10.1007/S13277-013-1433-4
1595995 - Piper trichostachyon: 10.1016/J.EJPHAR.2015.01.038
1595995 - Piper trichostachyon: 10.1016/J.FCT.2008.06.014
1595995 - Piper trichostachyon: 10.1016/J.INTIMP.2004.08.005
1595995 - Piper trichostachyon: 10.1016/S0031-9422(00)00226-0
1595995 - Piper trichostachyon: 10.1038/JA.2011.27
1595995 - Piper trichostachyon: 10.1055/S-1999-14031
1595995 - Piper trichostachyon: LTS0014461
247704 - Piper tuberculatum:
247704 - Piper tuberculatum: 10.1002/JBT.20251
247704 - Piper tuberculatum: 10.1007/S00044-008-9161-9
247704 - Piper tuberculatum: 10.1007/S13277-013-1433-4
247704 - Piper tuberculatum: 10.1016/J.BMC.2010.03.013
247704 - Piper tuberculatum: 10.1016/J.EJPHAR.2015.01.038
247704 - Piper tuberculatum: 10.1016/J.FCT.2008.06.014
247704 - Piper tuberculatum: 10.1016/J.INTIMP.2004.08.005
247704 - Piper tuberculatum: 10.1016/S0031-9422(00)00226-0
247704 - Piper tuberculatum: 10.1038/JA.2011.27
247704 - Piper tuberculatum: 10.1055/S-1999-14031
247704 - Piper tuberculatum: LTS0014461
16739 - Piperaceae: LTS0014461
33090 - Plants: -
28556 - Pleosporaceae: LTS0014461
4070 - Solanaceae: LTS0014461
35493 - Streptophyta: LTS0014461
58023 - Tracheophyta: LTS0014461
33090 - Viridiplantae: LTS0014461

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位		关联基因列表
Cytoplasm	11	ABCB1, ALB, CDKN1A, CTNNB1, EGFR, MTOR, PIK3CA, PTGS2, STAT3, TP53, VEGFA
Peripheral membrane protein	3	ACHE, MTOR, PTGS2
Endosome membrane	1	EGFR
Endoplasmic reticulum membrane	3	EGFR, MTOR, PTGS2
Nucleus	10	ACHE, ALB, CDKN1A, CTNNB1, EGFR, MTOR, PARP1, STAT3, TP53, VEGFA
cytosol	10	ALB, CDKN1A, CTNNB1, GPT, LEP, MTOR, PARP1, PIK3CA, STAT3, TP53
dendrite	1	MTOR
nuclear body	2	CDKN1A, PARP1
phagocytic vesicle	1	MTOR
centrosome	3	ALB, CTNNB1, TP53
nucleoplasm	6	CDKN1A, CTNNB1, MTOR, PARP1, STAT3, TP53
RNA polymerase II transcription regulator complex	1	STAT3
Cell membrane	5	ABCB1, ACHE, CTNNB1, EGFR, TRPV1
Cytoplasmic side	1	MTOR
lamellipodium	2	CTNNB1, PIK3CA
ruffle membrane	1	EGFR
Early endosome membrane	1	EGFR
Multi-pass membrane protein	2	ABCB1, TRPV1
Golgi apparatus membrane	1	MTOR
Synapse	2	ACHE, CTNNB1
cell cortex	1	CTNNB1
cell junction	2	CTNNB1, EGFR
cell surface	5	ABCB1, ACHE, ADIPOQ, EGFR, VEGFA
glutamatergic synapse	2	CTNNB1, EGFR
Golgi apparatus	3	ACHE, ALB, VEGFA
Golgi membrane	3	EGFR, INS, MTOR
lysosomal membrane	1	MTOR
neuromuscular junction	1	ACHE
neuronal cell body	1	TRPV1
presynaptic membrane	1	CTNNB1
Cytoplasm, cytosol	1	PARP1
Lysosome	1	MTOR
endosome	1	EGFR
plasma membrane	7	ABCB1, ACHE, CTNNB1, EGFR, PIK3CA, STAT3, TRPV1
Membrane	9	ABCB1, ACHE, CTNNB1, EGFR, MTOR, PARP1, TP53, TRPV1, VEGFA
apical plasma membrane	2	ABCB1, EGFR
basolateral plasma membrane	2	CTNNB1, EGFR
caveola	1	PTGS2
extracellular exosome	4	ABCB1, ALB, CTNNB1, GPT
Lysosome membrane	1	MTOR
endoplasmic reticulum	5	ADIPOQ, ALB, PTGS2, TP53, VEGFA
extracellular space	9	ACHE, ADIPOQ, ALB, EGFR, IL2, IL4, INS, LEP, VEGFA
perinuclear region of cytoplasm	5	ACHE, CDKN1A, CTNNB1, EGFR, PIK3CA
Schaffer collateral - CA1 synapse	1	CTNNB1
adherens junction	2	CTNNB1, VEGFA
apicolateral plasma membrane	1	CTNNB1
bicellular tight junction	1	CTNNB1
intercalated disc	1	PIK3CA
mitochondrion	2	PARP1, TP53
protein-containing complex	7	ALB, CDKN1A, CTNNB1, EGFR, PARP1, PTGS2, TP53
Microsome membrane	2	MTOR, PTGS2
TORC1 complex	1	MTOR
TORC2 complex	1	MTOR
Single-pass type I membrane protein	1	EGFR
Secreted	8	ACHE, ADIPOQ, ALB, IL2, IL4, INS, LEP, VEGFA
extracellular region	8	ACHE, ADIPOQ, ALB, IL2, IL4, INS, LEP, VEGFA
Mitochondrion outer membrane	1	MTOR
mitochondrial outer membrane	1	MTOR
Mitochondrion matrix	1	TP53
mitochondrial matrix	1	TP53
Extracellular side	1	ACHE
anchoring junction	1	ALB
transcription regulator complex	4	CTNNB1, PARP1, STAT3, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome	1	TP53
nuclear membrane	1	EGFR
external side of plasma membrane	1	TRPV1
Secreted, extracellular space, extracellular matrix	1	VEGFA
Z disc	1	CTNNB1
beta-catenin destruction complex	1	CTNNB1
nucleolus	3	CDKN1A, PARP1, TP53
Wnt signalosome	1	CTNNB1
apical part of cell	1	CTNNB1
cell-cell junction	1	CTNNB1
postsynaptic membrane	2	CTNNB1, TRPV1
Apical cell membrane	1	ABCB1
Membrane raft	1	EGFR
Cytoplasm, cytoskeleton	2	CTNNB1, TP53
focal adhesion	2	CTNNB1, EGFR
GABA-ergic synapse	1	TRPV1
Cell junction, adherens junction	1	CTNNB1
flotillin complex	1	CTNNB1
extracellular matrix	1	VEGFA
basement membrane	1	ACHE
collagen trimer	1	ADIPOQ
intracellular vesicle	1	EGFR
Nucleus, PML body	2	MTOR, TP53
PML body	2	MTOR, TP53
collagen-containing extracellular matrix	1	ADIPOQ
secretory granule	1	VEGFA
fascia adherens	1	CTNNB1
lateral plasma membrane	1	CTNNB1
Nucleus inner membrane	1	PTGS2
Nucleus outer membrane	1	PTGS2
nuclear inner membrane	1	PTGS2
nuclear outer membrane	1	PTGS2
Postsynaptic cell membrane	1	TRPV1
receptor complex	1	EGFR
Cell projection, neuron projection	1	TRPV1
neuron projection	1	PTGS2
ciliary basal body	1	ALB
chromatin	3	PARP1, STAT3, TP53
cell periphery	1	CTNNB1
Chromosome	1	PARP1
Cytoplasm, cytoskeleton, cilium basal body	1	CTNNB1
centriole	1	ALB
Nucleus, nucleolus	1	PARP1
spindle pole	2	ALB, CTNNB1
nuclear replication fork	1	PARP1
chromosome, telomeric region	1	PARP1
blood microparticle	1	ALB
postsynaptic density, intracellular component	1	CTNNB1
Lipid-anchor, GPI-anchor	1	ACHE
microvillus membrane	1	CTNNB1
site of double-strand break	2	PARP1, TP53
nuclear envelope	2	MTOR, PARP1
Endomembrane system	2	CTNNB1, MTOR
endosome lumen	1	INS
euchromatin	1	CTNNB1
side of membrane	1	ACHE
germ cell nucleus	1	TP53
replication fork	1	TP53
basal plasma membrane	1	EGFR
synaptic membrane	1	EGFR
secretory granule lumen	1	INS
Golgi lumen	1	INS
endoplasmic reticulum lumen	3	ALB, INS, PTGS2
nuclear matrix	1	TP53
transcription repressor complex	1	TP53
platelet alpha granule lumen	2	ALB, VEGFA
phosphatidylinositol 3-kinase complex	1	PIK3CA
phosphatidylinositol 3-kinase complex, class IA	1	PIK3CA
transport vesicle	1	INS
beta-catenin-TCF complex	1	CTNNB1
Endoplasmic reticulum-Golgi intermediate compartment membrane	1	INS
presynaptic active zone cytoplasmic component	1	CTNNB1
clathrin-coated endocytic vesicle membrane	1	EGFR
[Isoform 1]: Nucleus	1	TP53
synaptic cleft	1	ACHE
protein-DNA complex	2	CTNNB1, PARP1
external side of apical plasma membrane	1	ABCB1
Cytoplasmic vesicle, phagosome	1	MTOR
catenin complex	1	CTNNB1
site of DNA damage	1	PARP1
Cell projection, dendritic spine membrane	1	TRPV1
dendritic spine membrane	1	TRPV1
cyclin-dependent protein kinase holoenzyme complex	1	CDKN1A
multivesicular body, internal vesicle lumen	1	EGFR
Shc-EGFR complex	1	EGFR
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome	1	PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm	1	PARP1
PCNA-p21 complex	1	CDKN1A
[N-VEGF]: Cytoplasm	1	VEGFA
[VEGFA]: Secreted	1	VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum	1	VEGFA
[Isoform VEGF121]: Secreted	1	VEGFA
[Isoform VEGF165]: Secreted	1	VEGFA
VEGF-A complex	1	VEGFA
beta-catenin-TCF7L2 complex	1	CTNNB1
[Isoform H]: Cell membrane	1	ACHE
beta-catenin-ICAT complex	1	CTNNB1
Scrib-APC-beta-catenin complex	1	CTNNB1
phosphatidylinositol 3-kinase complex, class IB	1	PIK3CA
ciliary transition fiber	1	ALB

文献列表

Phanit Songvut, Tussapon Boonyarattanasoonthorn, Nitra Nuengchamnong, Thammaporn Junsai, Teetat Kongratanapasert, Kittitach Supannapan, Phisit Khemawoot. Enhancing oral bioavailability of andrographolide using solubilizing agents and bioenhancer: comparative pharmacokinetics of Andrographis paniculata formulations in beagle dogs. Pharmaceutical biology. 2024 Dec; 62(1):183-194. doi: 10.1080/13880209.2024.2311201. [PMID: 38351624]
Yifei Wu, Jiayu Zhang, Sha Du, Xiaochuan Wang, Jinrong Li, Yi Chen, Hongying Zhou, Su Gao, Yongrong Li, Xiuhong Liu. Combination of 308-nm excimer laser and piperine promotes melanocyte proliferation, migration, and melanin content production via the miR-328/SFRP1 axis. Photodermatology, photoimmunology & photomedicine. 2024 May; 40(3):e12970. doi: 10.1111/phpp.12970. [PMID: 38685665]
Kangyun Zhao, Siwei Zhang, Chunhong Piao, Fei Xu, Yutong Zhang, Xu Wang, Jiyue Zhang, Chunxia Zhao, Sang Guan You, Yanjun Zhang. Investigation of the formation mechanism of the pepper starch-piperine complex. International journal of biological macromolecules. 2024 May; 268(Pt 1):131777. doi: 10.1016/j.ijbiomac.2024.131777. [PMID: 38663710]
Bin Tang, Shangrong Hu, Yujia Luo, Dongmei Shi, Xiangyu Liu, Fan Zhong, Xinyi Jiang, Gao Hu, Can Li, Hongxia Duan, Yan Wu. Impact of Three Thiazolidinone Compounds with Piperine Skeletons on Trehalase Activity and Development of Spodoptera frugiperda Larvae. Journal of agricultural and food chemistry. 2024 Apr; 72(15):8423-8433. doi: 10.1021/acs.jafc.3c08898. [PMID: 38565327]
Asmaa Badawy Darwish, Amira Mohamed Mohsen, Shaimaa ElShebiney, Rania Elgohary, Mostafa Mohamed Younis. Development of chitosan lipid nanoparticles to alleviate the pharmacological activity of piperine in the management of cognitive deficit in diabetic rats. Scientific reports. 2024 04; 14(1):8247. doi: 10.1038/s41598-024-58601-x. [PMID: 38589438]
Lan Yu, Xiaolu Hu, Rongrong Xu, Yimeng Zhao, Lijuan Xiong, Jiaxuan Ai, Xing Wang, Xiaoqing Chen, Yinying Ba, Zhikai Xing, Chongye Guo, Shuangli Mi, Xia Wu. Piperine promotes PI3K/AKT/mTOR-mediated gut-brain autophagy to degrade α-Synuclein in Parkinson's disease rats. Journal of ethnopharmacology. 2024 Mar; 322(?):117628. doi: 10.1016/j.jep.2023.117628. [PMID: 38158101]
Meghana N Kumar, Sreeram Peringattu Kalarikkal, Yashaswini Jayaram, Janakiraman Narayanan, Gopinath M Sundaram. Protocol to produce plant-based hybrid nanovesicles from fresh turmeric and pepper using polyethylene glycol. STAR protocols. 2024 Mar; 5(1):102924. doi: 10.1016/j.xpro.2024.102924. [PMID: 38430518]
Protha Biswas, Devendra Kumar Pandey, Mahipal S Shekhawat, Abhijit Dey, Tabarak Malik. Tissue-specific variations of piperine in ten populations of Piper longum L.: bioactivities and toxicological profile. Scientific reports. 2024 03; 14(1):5062. doi: 10.1038/s41598-024-52297-9. [PMID: 38424458]
Koniyan Shaheer, Br Swathi Prabhu, H Shabeer Ali, Divya Lakshmanan-M. Breast cancer cells are sensitized by piperine to radiotherapy through estrogen receptor-α mediated modulation of a key NHEJ repair protein- DNA-PK. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 122(?):155126. doi: 10.1016/j.phymed.2023.155126. [PMID: 37913642]
Sakineh Rezaei, Hoda-Sadat Meftah, Yasamin Ebtehajpour, Hamid Reza Rahimi, Jamshidkhan Chamani. Investigation on the Effect of Fluorescence Quenching of Calf Thymus DNA by Piperine: Caspase Activation in the Human Breast Cancer Cell Line Studies. DNA and cell biology. 2024 Jan; 43(1):26-38. doi: 10.1089/dna.2023.0269. [PMID: 38079271]
Jin Han, Shaoyong Zhang, Jun He, Tianze Li. Piperine: Chemistry and Biology. Toxins. 2023 Dec; 15(12):. doi: 10.3390/toxins15120696. [PMID: 38133200]
Kosar Boshagh, Fariborz Khorvash, Amirhossein Sahebkar, Muhammed Majeed, Nimah Bahreini, Gholamreza Askari, Mohammad Bagherniya. The effects of curcumin-piperine supplementation on inflammatory, oxidative stress and metabolic indices in patients with ischemic stroke in the rehabilitation phase: a randomized controlled trial. Nutrition journal. 2023 Dec; 22(1):69. doi: 10.1186/s12937-023-00905-1. [PMID: 38082237]
Ying Liu, Rui Zhu, Xinwei Liu, Dengzhou Li, Mengyu Guo, Bing Fei, Yanying Ren, Xiaojuan You, Yongwei Li. Effect of piperine on the inhibitory potential of MexAB-OprM efflux pump and imipenem resistance in carbapenem-resistant Pseudomonas aeruginosa. Microbial pathogenesis. 2023 Dec; 185(?):106397. doi: 10.1016/j.micpath.2023.106397. [PMID: 37852553]
Claudia Patricia Bravo-Chaucanés, Luis Carlos Chitiva, Yerly Vargas-Casanova, Valentina Diaz-Santoyo, Andrea Ximena Hernández, Geison M Costa, Claudia Marcela Parra-Giraldo. Exploring the Potential Mechanism of Action of Piperine against Candida albicans and Targeting Its Virulence Factors. Biomolecules. 2023 11; 13(12):. doi: 10.3390/biom13121729. [PMID: 38136600]
Maria D Octavia, Hasmiwati Hasmiwati, Gusti Revilla, Erizal Zaini. Effect of multicomponent crystal of piperine-nicotinic acid on antihyperlipidemic activity in rats. Pakistan journal of pharmaceutical sciences. 2023 Nov; 36(6):1777-1781. doi: . [PMID: 38124418]
Muhammed Majeed, Kalyanam Nagabhushanam, Avinash Murali, Devarajan T Vishwanathan, Ramamohan V Mamidala, Lakshmi Mundkur. A Standardized Withania somniferra (Linn.) Root Extract with Piperine Alleviates the Symptoms of Anxiety and Depression by Increasing Serotonin Levels: A Double-Blind, Randomized, Placebo-Controlled Study. Journal of integrative and complementary medicine. 2023 Oct; ?(?):. doi: 10.1089/jicm.2023.0279. [PMID: 37878284]
Pu Jian, Takuto Kumano, Mio Kimura, Makoto Kurisaki, Yoshiteru Hashimoto, Michihiko Kobayashi. Biodegradation of the methylenedioxyphenyl group in piperine and its derivatives: discovery of a novel methylenetransferase in an actinomycete. Applied and environmental microbiology. 2023 Oct; ?(?):e0114523. doi: 10.1128/aem.01145-23. [PMID: 37874289]
Sohail Hussain, Abdulmajeed M Jali, Saeed Alshahrani, Khairat H M Khairat, Rahimullah Siddiqui, Mohammad Intakhab Alam, Raisuddin Ali, Manal Mohammed, Andleeb Khan, Hamad Al Shahi, Ali Hanbashi, Marwa Qadri, Mohammad Ashafaq. Hepatoprotective and Antioxidant Effects of Nanopiperine against Cypermethrin via Mitigation of Oxidative Stress, Inflammations and Gene Expression Using qRT-PCR. International journal of molecular sciences. 2023 Oct; 24(20):. doi: 10.3390/ijms242015361. [PMID: 37895045]
Rizal Subahar, Ayleen Huang, Rafaella Shiene Wijaya, Lia Savitri Eka Nur, Lisawati Susanto, Nurhadi Eko Firmansyah, Yulhasri Yulhasri, Gulshan Fahmi El Bayani, Surya Dwira. First report on evaluation of commercial eugenol and piperine against Aedes aegypti L (Diptera: Culicidae) larvae: Mortality, detoxifying enzyme, and histopathological changes in the midgut. Parasitology international. 2023 Oct; ?(?):102813. doi: 10.1016/j.parint.2023.102813. [PMID: 37793471]
Yuanyuan Lv, Jinjin Zhu, Sihui Huang, Xiaoli Xing, Shen Zhou, Hui Yao, Zhuang Yang, Ling Liu, Sishu Huang, Yuanyuan Miao, Xianqing Liu, Alisdair R Fernie, Yuanhao Ding, Jie Luo. Metabolome profiling and transcriptome analysis filling the early crucial missing steps of piperine biosynthesis in Piper nigrum L. The Plant journal : for cell and molecular biology. 2023 Sep; ?(?):. doi: 10.1111/tpj.16476. [PMID: 37753665]
Xuejiao Wang, Jiangbin Wang, Helin Li. Enhanced anticancer activity of piperine: Structural optimization and chitosan-based microgels with boosted drug delivery. International journal of biological macromolecules. 2023 Sep; 253(Pt 5):127019. doi: 10.1016/j.ijbiomac.2023.127019. [PMID: 37739282]
Sri-Arun Iamjan, Siriluk Veerasakul, Samur Thanoi, Waree Tiyaboonchai, Sutisa Nudmamud-Thanoi. A solid lipid particle formulation of long pepper extract reduces pain and astrocyte activation in a rat model of neuropathic pain. Journal of complementary & integrative medicine. 2023 Sep; ?(?):. doi: 10.1515/jcim-2023-0043. [PMID: 37712769]
Ligang Yu, Xiaoyue Zhang, Wenyan Sun, Guang Shen, Yukun Yang, Maomao Zeng. The influence of piperine on oxidation-induced porcine myofibrillar protein gelation behavior and fluorescent advanced glycation end products formation in model systems. Food chemistry. 2023 Sep; 420(?):136119. doi: 10.1016/j.foodchem.2023.136119. [PMID: 37060667]
Zehra Omeroglu Ulu, Nurdan Sena Degirmenci, Zeynep Busra Bolat, Fikrettin Sahin. Synergistic anti-cancer effect of sodium pentaborate pentahydrate, curcumin and piperine on hepatocellular carcinoma cells. Scientific reports. 2023 09; 13(1):14404. doi: 10.1038/s41598-023-40809-y. [PMID: 37658091]
Xiaolu Hu, Lan Yu, Yatong Li, Xiaoxi Li, Yimeng Zhao, Lijuan Xiong, Jiaxuan Ai, Qijun Chen, Xing Wang, Xiaoqing Chen, Yinying Ba, Yaonan Wang, Xia Wu. Piperine improves levodopa availability in the 6-OHDA-lesioned rat model of Parkinson's disease by suppressing gut bacterial tyrosine decarboxylase. CNS neuroscience & therapeutics. 2023 Aug; ?(?):. doi: 10.1111/cns.14383. [PMID: 37528534]
Di Wu, Xia Hu, Zhangyu Cai, Jing Zhang, Fang Geng, Hui Li. Binding behavior and antioxidant study of spice extract piperine with respect to meat myoglobin. Food & function. 2023 Jul; 14(14):6422-6431. doi: 10.1039/d3fo00617d. [PMID: 37395089]
Sharmistha Das, Ritwik Roy, Payel Paul, Poulomi Chakraborty, Sudipta Chatterjee, Moumita Malik, Sarita Sarkar, Anirban Das Gupta, Debasish Maiti, Prosun Tribedi. Piperine, a Plant Alkaloid, Exhibits Efficient Disintegration of the Pre-existing Biofilm of Staphylococcus aureus: a Step Towards Effective Management of Biofilm Threats. Applied biochemistry and biotechnology. 2023 Jun; ?(?):. doi: 10.1007/s12010-023-04610-x. [PMID: 37389724]
Hanieh Karimi, Shahram Rabbani, Delaram Babadi, Simin Dadashzadeh, Azadeh Haeri. Piperine liposome-embedded in hyaluronan hydrogel as an effective platform for prevention of postoperative peritoneal adhesion. Journal of microencapsulation. 2023 Jun; 40(4):279-301. doi: 10.1080/02652048.2023.2194415. [PMID: 36948888]
Min Lv, Shaochen Li, Houpeng Wen, Yanyan Wang, Jiawei Du, Hui Xu. Expedient discovery of novel oxime ester derivatives of piperine/piperine analogs as potent pesticide candidates and their mode of action against Tetranychus cinnabarinus Boisduval. Pest management science. 2023 May; ?(?):. doi: 10.1002/ps.7521. [PMID: 37139821]
Niloofar Ghobadi, Ahmad Asoodeh. Co-administration of curcumin with other phytochemicals improves anticancer activity by regulating multiple molecular targets. Phytotherapy research : PTR. 2023 Mar; ?(?):. doi: 10.1002/ptr.7794. [PMID: 36883534]
Kamil Wdowiak, Andrzej Miklaszewski, Robert Pietrzak, Judyta Cielecka-Piontek. Amorphous System of Hesperetin and Piperine-Improvement of Apparent Solubility, Permeability, and Biological Activities. International journal of molecular sciences. 2023 Mar; 24(5):. doi: 10.3390/ijms24054859. [PMID: 36902286]
Shima Sharifi, Mohammad Bagherniya, Ziba Khoram, Amrollah Ebrahimi Varzaneh, Stephen L Atkin, Tannaz Jamialahmadi, Amirhossein Sahebkar, Gholamreza Askari. Efficacy of curcumin plus piperine co-supplementation in moderate-to-high hepatic steatosis: A double-blind, randomized, placebo-controlled clinical trial. Phytotherapy research : PTR. 2023 Feb; ?(?):. doi: 10.1002/ptr.7764. [PMID: 36799355]
Hajar Heidari, Mohammad Bagherniya, Muhammed Majeed, Thozhukat Sathyapalan, Tannaz Jamialahmadi, Amirhossein Sahebkar. Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies. Phytotherapy research : PTR. 2023 Jan; ?(?):. doi: 10.1002/ptr.7737. [PMID: 36720711]
Lais Silva Morais, João Paulo Barreto Sousa, Carolina Melo Aguiar, Ciro Martins Gomes, Daniel Pecoraro Demarque, Lorena Carneiro Albernaz, Laila Salmen Espindola. Edible Plant Extracts against Aedes aegypti and Validation of a Piper nigrum L. Ethanolic Extract as a Natural Insecticide. Molecules (Basel, Switzerland). 2023 Jan; 28(3):. doi: 10.3390/molecules28031264. [PMID: 36770931]
Hossein Hosseini, Farideh Ghavidel, Ghodratollah Panahi, Muhammed Majeed, Amirhossein Sahebkar. A systematic review and meta-analysis of randomized controlled trials investigating the effect of the curcumin and piperine combination on lipid profile in patients with metabolic syndrome and related disorders. Phytotherapy research : PTR. 2023 Jan; ?(?):. doi: 10.1002/ptr.7730. [PMID: 36649934]
Fanli Shi, Ruilong Li, Wenjing Wang, Xiangyu Yu, Fenxia Zhu, Yiping Huang, Jing Wang, Zhenhai Zhang. Carboxymethyl starch as a solid dispersion carrier to enhance the dissolution and bioavailability of piperine and 18β-glycyrrhetinic acid. Drug development and industrial pharmacy. 2023 Jan; 49(1):30-41. doi: 10.1080/03639045.2023.2182120. [PMID: 36803327]
Isha Gupta, Syeda Nashvia Adin, Mohd Aqil, Mohd Mujeeb, Yasmin Sultana. Quality by design-based development and validation of an HPLC method for simultaneous estimation of pregabalin and piperine in dual drug-loaded liposomes. Biomedical chromatography : BMC. 2023 Jan; 37(1):e5510. doi: 10.1002/bmc.5510. [PMID: 36100737]
Sagar Joshi, Salahuddin, Avijit Mazumder, Rajnish Kumar, Km Shabana, Sonakshi Tyagi, Kavita Rana, Mohamed Jawed Ahsan, Mohammad Shahar Yar, Arvind Arya, Navneet Khurana. Significant Advancement in Various Synthetic Strategies and Pharmacotherapy of Piperine Derivatives: A Review. Current topics in medicinal chemistry. 2023; 23(25):2394-2415. doi: 10.2174/0115680266256255231009075303. [PMID: 37828679]
Shaochen Li, Min Lv, Hui Xu. Overview of Piperine: Bioactivities, Total Synthesis, Structural Modification, and Structure-Activity Relationships. Mini reviews in medicinal chemistry. 2023; 23(8):917-940. doi: 10.2174/1389557522666220726121012. [PMID: 35894471]
Mohsin Kazi, Muhammad Farooq Khan, Fahd A Nasr, Mohammad Z Ahmed, Ali S Alqahtani, Meser M Ali, Mohammed S Aldughaim. Development of Curcumin and Piperine-Loaded Bio-Active Self-Nanoemulsifying Drugs and Investigation of Their Bioactivity in Zebrafish Embryos and Human Hematological Cancer Cell Lines. International journal of nanomedicine. 2023; 18(?):1793-1808. doi: 10.2147/ijn.s400330. [PMID: 37051315]
Tianze Li, Min Lv, Houpeng Wen, Jingru Wang, Zhen Wang, Jianwei Xu, Shanshan Fang, Hui Xu. High Value-Added Application of Natural Plant Products in Crop Protection: Construction and Pesticidal Activities of Piperine-Type Ester Derivatives and Their Toxicology Study. Journal of agricultural and food chemistry. 2022 Dec; 70(51):16126-16134. doi: 10.1021/acs.jafc.2c06136. [PMID: 36525582]
Tussapon Boonyarattanasoonthorn, Teetat Kongratanapasert, Arnatchai Maiuthed, Robert Hamlin, Anusak Kijtawornrat, Phisit Khemawoot. Bioenhancing effects of piperine and curcumin on triterpenoid pharmacokinetics and neurodegenerative metabolomes from Centella asiatica extract in beagle dogs. Scientific reports. 2022 12; 12(1):20789. doi: 10.1038/s41598-022-24935-7. [PMID: 36456663]
Jirakrit Saetang, Aman Tedasen, Surasak Sangkhathat, Natnaree Sangkaew, Sirinapa Dokduang, Napat Prompat, Siriporn Taraporn, Potchanapond Graidist. The attenuation effect of low piperine Piper nigrum extract on doxorubicin-induced toxicity of blood chemical and immunological properties in mammary tumour rats. Pharmaceutical biology. 2022 Dec; 60(1):96-107. doi: 10.1080/13880209.2021.2018470. [PMID: 34962450]
Xiong Wang, Yanhua Zhang, Lei Zhang, Wenli Wang, Huilian Che, Yali Zhang. Piperine attenuates hepatic steatosis and insulin resistance in high-fat diet-induced obesity in Sprague-Dawley rats. Nutrition research (New York, N.Y.). 2022 Dec; 108(?):9-21. doi: 10.1016/j.nutres.2022.10.007. [PMID: 36375392]
Murugammal Shanmugam, Subashini Subramanian, Shakila Ramachandran. Method development and validation for quantification of six bioactive compounds (andrographolide, columbin, piperine, gallic, paracoumaric and oleanolic acids) by HPTLC. Journal of complementary & integrative medicine. 2022 Nov; ?(?):. doi: 10.1515/jcim-2022-0135. [PMID: 36384045]
Chandan Sarkar, Milon Mondal, Khattab Al-Khafaji, Dina M El-Kersh, Sarmin Jamaddar, Pranta Ray, Uttam Kumar Roy, Mirola Afroze, Md Moniruzzaman, Mala Khan, Umma Hafsa Asha, Abul Bashar Ripon Khalipha, Edna Mori, Bruna Caroline Gonçalves Vasconcelos de Lacerda, Isaac Moura Araújo, Henrique Douglas Melo Coutinho, Manik Chandra Shill, Muhammad Torequl Islam. GC-MS analysis, and evaluation of protective effect of Piper chaba stem bark against paracetamol-induced liver damage in Sprague-Dawley rats: Possible defensive mechanism by targeting CYP2E1 enzyme through in silico study. Life sciences. 2022 Nov; 309(?):121044. doi: 10.1016/j.lfs.2022.121044. [PMID: 36208657]
Luiza V Vieira, Maria Eduarda M Juvenato, Maiara Krause, Otávio A Heringer, Juliano S Ribeiro, Geisamanda P Brandão, Ricardo M Kuster, Maria Tereza W D Carneiro. The effects of drying methods and harvest season on piperine, essential oil composition, and multi-elemental composition of black pepper. Food chemistry. 2022 Oct; 390(?):133148. doi: 10.1016/j.foodchem.2022.133148. [PMID: 35551027]
Jameel Mohammed Al-Khayri, Vinayak Upadhya, Sandeep Ramachandra Pai, Poornananda Madhava Naik, Muneera Qassim Al-Mssallem, Fatima Mohammed Alessa. Comparative Quantification of the Phenolic Compounds, Piperine Content, and Total Polyphenols along with the Antioxidant Activities in the Piper trichostachyon and P. nigrum. Molecules (Basel, Switzerland). 2022 Sep; 27(18):. doi: 10.3390/molecules27185965. [PMID: 36144701]
Masakazu Ishii, Haruka Miyata, Nao Ikeda, Takashi Tagawa, Masahiro Nishimura. Piper retrofractum extract and its component piperine promote lymphangiogenesis via an AKT- and ERK-dependent mechanism. Journal of food biochemistry. 2022 09; 46(9):e14233. doi: 10.1111/jfbc.14233. [PMID: 35567300]
Zhiyang Jiang, Dongmei Shi, Huilin Li, Danchan He, Kai Zhu, Jingyi Li, Yunjiang Zi, Zhijian Xu, Jiaxing Huang, Hongxia Duan, Qing Yang. Rational Design and Identification of Novel Piperine Derivatives as Multichitinase Inhibitors. Journal of agricultural and food chemistry. 2022 Aug; 70(33):10326-10336. doi: 10.1021/acs.jafc.2c03751. [PMID: 35960858]
Luise Jäckel, Arianne Schnabel, Hagen Stellmach, Ulrike Klauß, Susanne Matschi, Gerd Hause, Thomas Vogt. The terminal enzymatic step in piperine biosynthesis is co-localized with the product piperine in specialized cells of black pepper (Piper nigrum L.). The Plant journal : for cell and molecular biology. 2022 08; 111(3):731-747. doi: 10.1111/tpj.15847. [PMID: 35634755]
Gholamreza Askari, Amirhossein Sahebkar, Davood Soleimani, Atena Mahdavi, Sahar Rafiee, Muhammed Majeed, Farzin Khorvash, Bijan Iraj, Mahshid Elyasi, Mohammad Hossein Rouhani, Mohammad Bagherniya. The efficacy of curcumin-piperine co-supplementation on clinical symptoms, duration, severity, and inflammatory factors in COVID-19 outpatients: a randomized double-blind, placebo-controlled trial. Trials. 2022 Jun; 23(1):472. doi: 10.1186/s13063-022-06375-w. [PMID: 35668500]
Jirakrit Saetang, Aman Tedasen, Surasak Sangkhathat, Natnaree Sangkaew, Sirinapa Dokduang, Napat Prompat, Siriporn Taraporn, Potchanapond Graidist. Low Piperine Fractional Piper nigrum Extract Enhanced the Antitumor Immunity via Regulating the Th1/Th2/Treg Cell Subsets on NMU-Induced Tumorigenesis Rats. Planta medica. 2022 Jun; 88(7):527-537. doi: 10.1055/a-1458-5646. [PMID: 33902130]
Nayyer Islam, Muhammad Irfan, Talib Hussain, Maria Mushtaq, Ikram Ullah Khan, Abid Mehmood Yousaf, Muhammad Usman Ghori, Yasser Shahzad. Piperine phytosomes for bioavailability enhancement of domperidone. Journal of liposome research. 2022 Jun; 32(2):172-180. doi: 10.1080/08982104.2021.1918153. [PMID: 33944662]
Joice Guilherme de Oliveira, Harry Luiz Pilz-Júnior, Alessandra Bittencourt de Lemos, Felipe Allan da Silva da Costa, Millena Fernandes, Douglas Zelinger Gonçalves, Paula Fassicolo Variza, Fernanda Mendes de Moraes, Fernando Dal Pont Morisso, Rachel Faverzani Magnago, Karine Modolon Zepon, Luiz Alberto Kanis, Onilda Santos da Silva, Josiane Somariva Prophiro. Polymer-based nanostructures loaded with piperine as a platform to improve the larvicidal activity against Aedes aegypti. Acta tropica. 2022 Jun; 230(?):106395. doi: 10.1016/j.actatropica.2022.106395. [PMID: 35278367]
Weiyun Zhang, Chi-Tang Ho, Muwen Lu. Piperine Improves Lipid Dysregulation by Modulating Circadian Genes Bmal1 and Clock in HepG2 Cells. International journal of molecular sciences. 2022 May; 23(10):. doi: 10.3390/ijms23105611. [PMID: 35628429]
Eman M M Shehata, Mennatallah A Gowayed, Samar O El-Ganainy, Eman Sheta, Yosra S R Elnaggar, Ossama Y Abdallah. Pectin coated nanostructured lipid carriers for targeted piperine delivery to hepatocellular carcinoma. International journal of pharmaceutics. 2022 May; 619(?):121712. doi: 10.1016/j.ijpharm.2022.121712. [PMID: 35367582]
Rattanaporn Wansri, Aye Chan Khine Lin, Jutharat Pengon, Sumalee Kamchonwongpaisan, Nitipol Srimongkolpithak, Roonglawan Rattanajak, Patcharin Wilasluck, Peerapon Deetanya, Kittikhun Wangkanont, Kowit Hengphasatporn, Yasuteru Shigeta, Jatupol Liangsakul, Aphinya Suroengrit, Siwaporn Boonyasuppayakorn, Taksina Chuanasa, Wanchai De-Eknamkul, Supot Hannongbua, Thanyada Rungrotmongkol, Supakarn Chamni. Semi-Synthesis of N-Aryl Amide Analogs of Piperine from Piper nigrum and Evaluation of Their Antitrypanosomal, Antimalarial, and Anti-SARS-CoV-2 Main Protease Activities. Molecules (Basel, Switzerland). 2022 Apr; 27(9):. doi: 10.3390/molecules27092841. [PMID: 35566194]
Lara Dürr, Tanja Hell, Maciej Dobrzyński, Alberto Mattei, Anika John, Nathanja Augsburger, Gloria Bradanini, Jakob K Reinhardt, Florian Rossberg, Milos Drobnjakovic, Mahabir P Gupta, Matthias Hamburger, Olivier Pertz, Eliane Garo. High-Content Screening Pipeline for Natural Products Targeting Oncogenic Signaling in Melanoma. Journal of natural products. 2022 04; 85(4):1006-1017. doi: 10.1021/acs.jnatprod.1c01154. [PMID: 35231173]
Nikhitha Lakshmi, Ameer Basha Shaik, Pragya Paramita Pal, Sajeli Begum Ahil, Ramya Vittal, Saida Naik, Uma Devi Gali, Vidya Sagar Bokka. Piperine, Reserpine and β-Sitosterol Attenuate Stem Rot (Sclerotium rolfsii Sacc.) of Groundnut by Inducing the Secretion of defense Enzymes and Phenolic Acids. Chemistry & biodiversity. 2022 Apr; 19(4):e202100880. doi: 10.1002/cbdv.202100880. [PMID: 35182415]
Ruolin Li, Yongquan Lu, Qidi Zhang, Weijin Liu, Runing Yang, Jie Jiao, Jia Liu, Ge Gao, Hui Yang. Piperine promotes autophagy flux by P2RX4 activation in SNCA/α-synuclein-induced Parkinson disease model. Autophagy. 2022 03; 18(3):559-575. doi: 10.1080/15548627.2021.1937897. [PMID: 34092198]
Pravin Kumar, Dinesh Kumar Sharma, Mahendra Singh Ashawat. Topical creams of piperine loaded lipid nanocarriers for management of atopic dermatitis: development, characterization, and in vivo investigation using BALB/c mice model. Journal of liposome research. 2022 Mar; 32(1):62-73. doi: 10.1080/08982104.2021.1880436. [PMID: 33944670]
Mayuko Itaya, Taiki Miyazawa, Saoussane Khalifa, Naoki Shimizu, Kiyotaka Nakagawa. The inhibition of interaction with serum albumin enhances the physiological activity of curcumin by increasing its cellular uptake. Food & function. 2022 Jan; 13(2):639-648. doi: 10.1039/d1fo03234h. [PMID: 34931204]
Mohd Imran, Monalisha Samal, Abdul Qadir, Asad Ali, Showkat R Mir. A critical review on the extraction and pharmacotherapeutic activity of piperine. Polimery w medycynie. 2022 Jan; 52(1):31-36. doi: 10.17219/pim/145512. [PMID: 35196422]
Mohit Kumar, Devesh Kumar, Sumant Kumar, Akshay Kumar, Uttam Kumar Mandal. A Recent Review on Bio-availability Enhancement of Poorly Water-soluble Drugs by using Bioenhancer and Nanoparticulate Drug Delivery System. Current pharmaceutical design. 2022; 28(39):3212-3224. doi: 10.2174/1381612829666221021152354. [PMID: 36281868]
Génesis V Buitimea-Cantúa, Héctor Manuel Leija Gutiérrez, Nydia E Buitimea-Cantúa, María Del Refugio Rocha-Pizaña, Antonio García-Triana, Alejandro Hernández-Morales, Elisa Magaña-Barajas, Jorge Molina-Torres. The aflatoxin inhibitors capsaicin and piperine from Capsicum chinense and Piper nigrum fruits modulate the antioxidant system in Aspergillus parasiticus. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2022; 57(5):358-368. doi: 10.1080/03601234.2022.2060029. [PMID: 35392762]
Dheeran Rajarajan, Jagadish Natesh, Dhanamjai Penta, Syed Musthapa Meeran. Dietary Piperine Suppresses Obesity-Associated Breast Cancer Growth and Metastasis by Regulating the miR-181c-3p/PPARα Axis. Journal of agricultural and food chemistry. 2021 Dec; 69(51):15562-15574. doi: 10.1021/acs.jafc.1c05670. [PMID: 34905918]
Sharmistha Das, Payel Paul, Sudipta Chatterjee, Poulomi Chakraborty, Ranojit K Sarker, Amlan Das, Debasish Maiti, Prosun Tribedi. Piperine exhibits promising antibiofilm activity against Staphylococcus aureus by accumulating reactive oxygen species (ROS). Archives of microbiology. 2021 Dec; 204(1):59. doi: 10.1007/s00203-021-02642-7. [PMID: 34940904]
Sayan Biswas, Amit Kar, Nanaocha Sharma, Pallab K Haldar, Pulok K Mukherjee. Synergistic effect of ursolic acid and piperine in CCl4 induced hepatotoxicity. Annals of medicine. 2021 12; 53(1):2009-2017. doi: 10.1080/07853890.2021.1995625. [PMID: 34751064]
Wenli Wang, Yanhua Zhang, Xiong Wang, Huilian Che, Yali Zhang. Piperine Improves Obesity by Inhibiting Fatty Acid Absorption and Repairing Intestinal Barrier Function. Plant foods for human nutrition (Dordrecht, Netherlands). 2021 Dec; 76(4):410-418. doi: 10.1007/s11130-021-00919-2. [PMID: 34591253]
Khaled AbouAitah, Imane M Higazy, Anna Swiderska-Sroda, Reda M Abdelhameed, Stanislaw Gierlotka, Tarik A Mohamed, Urszula Szałaj, Witold Lojkowski. Anti-inflammatory and antioxidant effects of nanoformulations composed of metal-organic frameworks delivering rutin and/or piperine natural agents. Drug delivery. 2021 Dec; 28(1):1478-1495. doi: 10.1080/10717544.2021.1949073. [PMID: 34254539]
Xiangge Tian, Meirong Zhou, Jing Ning, Xiaopeng Deng, Lei Feng, Huilian Huang, Dahong Yao, Xiaochi Ma. The development of novel cytochrome P450 2J2 (CYP2J2) inhibitor and the underlying interaction between inhibitor and CYP2J2. Journal of enzyme inhibition and medicinal chemistry. 2021 Dec; 36(1):737-748. doi: 10.1080/14756366.2021.1896500. [PMID: 33682565]
Yuanhao Ding, Yuyuan Mao, Yi Cen, Lisong Hu, Yuefeng Su, Xuemin Ma, Lu Long, Haiyan Hu, Chaoyun Hao, Jie Luo. Small RNA sequencing reveals various microRNAs involved in piperine biosynthesis in black pepper (Piper nigrum L.). BMC genomics. 2021 Nov; 22(1):838. doi: 10.1186/s12864-021-08154-4. [PMID: 34794378]
Shivaprasad Shilpa, Hulikere Jagdish Shwetha, Madan Kumar Perumal, Rudrappa Ambedkar, Manjunatha Hanumanthappa, Vallikannan Baskaran, Rangaswamy Lakshminarayana. Turmeric, red pepper, and black pepper affect carotenoids solubilized micelles properties and bioaccessibility: Capsaicin/piperine improves and curcumin inhibits carotenoids uptake and transport in Caco-2 cells. Journal of food science. 2021 Nov; 86(11):4877-4891. doi: 10.1111/1750-3841.15926. [PMID: 34658029]
Joana Furtado de Figueiredo Neta, Vivian Saraiva Veras, Danilo Ferreira de Sousa, Maria da Conceição Dos Santos Oliveira Cunha, Maria Veraci Oliveira Queiroz, José Claudio Garcia Lira Neto, Marta Maria Coelho Damasceno, Márcio Flávio Moura de Araújo, Roberto Wagner Júnior Freire de Freitas. Effectiveness of the piperine-supplemented Curcuma longa L. in metabolic control of patients with type 2 diabetes: a randomised double-blind placebo-controlled clinical trial. International journal of food sciences and nutrition. 2021 Nov; 72(7):968-977. doi: 10.1080/09637486.2021.1885015. [PMID: 33586583]
Alana Shunnarah, Robin Tumlinson, Angela I Calderón. Natural Products with Potential for Nonhormonal Male Contraception. Journal of natural products. 2021 10; 84(10):2762-2774. doi: 10.1021/acs.jnatprod.1c00565. [PMID: 34633803]
Vishal Sharad Chaudhari, Basveshwar Gawali, Pritam Saha, V G M Naidu, Upadhyayula Suryanarayana Murty, Subham Banerjee. Quercetin and piperine enriched nanostructured lipid carriers (NLCs) to improve apoptosis in oral squamous cellular carcinoma (FaDu cells) with improved biodistribution profile. European journal of pharmacology. 2021 Oct; 909(?):174400. doi: 10.1016/j.ejphar.2021.174400. [PMID: 34332920]
A Vurmaz, E Atay. Antioxidant effects of piperine on steroid-induced hepatotoxicity. European review for medical and pharmacological sciences. 2021 Sep; 25(17):5500-5506. doi: 10.26355/eurrev_202109_26659. [PMID: 34533800]
Ameeduzzafar Zafar, Nabil K Alruwaili, Syed Sarim Imam, Omar Awad Alsaidan, Khalid Saad Alharbi, Mohd Yasir, Mohammed Elmowafy, Elshaer F Mohammed, Ziad H Al-Oanzi. Formulation of Chitosan-Coated Piperine NLCs: Optimization, In Vitro Characterization, and In Vivo Preclinical Assessment. AAPS PharmSciTech. 2021 Aug; 22(7):231. doi: 10.1208/s12249-021-02098-4. [PMID: 34477999]
Acharya Balkrishna, Priyanka Sharma, Monali Joshi, Jyotish Srivastava, Anurag Varshney. Development and validation of a rapid high-performance thin-layer chromatographic method for quantification of gallic acid, cinnamic acid, piperine, eugenol, and glycyrrhizin in Divya-Swasari-Vati, an ayurvedic medicine for respiratory ailments. Journal of separation science. 2021 Aug; 44(16):3146-3157. doi: 10.1002/jssc.202100096. [PMID: 34101986]
Qing Han, Nan Wu, Hui-Lin Li, Jing-Yu Zhang, Xiang Li, Ming-Fei Deng, Kai Zhu, Jin-E Wang, Hong-Xia Duan, Qing Yang. A Piperine-Based Scaffold as a Novel Starting Point to Develop Inhibitors against the Potent Molecular Target OfChtI. Journal of agricultural and food chemistry. 2021 Jul; 69(27):7534-7544. doi: 10.1021/acs.jafc.0c08119. [PMID: 34185539]
Christian Rafael Quijia, Victor Hugo Araujo, Marlus Chorilli. Piperine: Chemical, biological and nanotechnological applications. Acta pharmaceutica (Zagreb, Croatia). 2021 Jun; 71(2):185-213. doi: 10.2478/acph-2021-0015. [PMID: 33151173]
Yanting Yuan, Ji Zhou, Ruixin Hu, Linhai Zou, Lixia Ji, Guohui Jiang. Piperine protects against pancreatic β-cell dysfunction by alleviating macrophage inflammation in obese mice. Life sciences. 2021 Jun; 274(?):119312. doi: 10.1016/j.lfs.2021.119312. [PMID: 33667521]
Howard H Bailey, Jeremy J Johnson, Taja Lozar, Cameron O Scarlett, Barbara W Wollmer, KyungMann Kim, Thomas Havinghurst, Nihal Ahmad. A randomized, double-blind, dose-ranging, pilot trial of piperine with resveratrol on the effects on serum levels of resveratrol. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 2021 05; 30(3):285-290. doi: 10.1097/cej.0000000000000621. [PMID: 32868637]
Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Lokanatha Oruganti, Karunakaran Reddy Sankaran, Haritha Goud Dinnupati, Venkata Subbaiah Kotakadi, Balaji Meriga. Anti-adipogenic and lipid-lowering activity of piperine and epigallocatechin gallate in 3T3-L1 adipocytes. Archives of physiology and biochemistry. 2021 Apr; ?(?):1-8. doi: 10.1080/13813455.2021.1908366. [PMID: 33836628]
Arianne Schnabel, Benedikt Athmer, Kerstin Manke, Frank Schumacher, Fernando Cotinguiba, Thomas Vogt. Identification and characterization of piperine synthase from black pepper, Piper nigrum L. Communications biology. 2021 04; 4(1):445. doi: 10.1038/s42003-021-01967-9. [PMID: 33833371]
Archana Thakre, Vyankatesh Jadhav, Rubina Kazi, Amruta Shelar, Rajendra Patil, Kiran Kharat, Gajanan Zore, S Mohan Karuppayil. Oxidative stress induced by piperine leads to apoptosis in Candida albicans. Medical mycology. 2021 Apr; 59(4):366-378. doi: 10.1093/mmy/myaa058. [PMID: 32658959]
Roland Wedekind, Pekka Keski-Rahkonen, Nivonirina Robinot, Vivian Viallon, Joseph A Rothwell, Marie-Christine Boutron-Ruault, Krasimira Aleksandrova, Clemens Wittenbecher, Matthias B Schulze, Jytte Halkjaer, Agnetha Linn Rostgaard-Hansen, Rudolf Kaaks, Verena Katzke, Giovanna Masala, Rosario Tumino, Maria Santucci de Magistris, Vittorio Krogh, Carlotta Sacerdote, Paula Jakszyn, Elisabete Weiderpass, Marc J Gunter, Inge Huybrechts, Augustin Scalbert. Pepper Alkaloids and Processed Meat Intake: Results from a Randomized Trial and the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort. Molecular nutrition & food research. 2021 04; 65(7):e2001141. doi: 10.1002/mnfr.202001141. [PMID: 33592132]
Shanmugam Ramaswamy, Kuppusamy Gowthamarajan, Lalitha Priyanka Dwarampudi, Mahendran Bhaskaran, Madhuri Kadiyala. Analytical method development, validation and forced degradation studies for rutin, quercetin, curcumin, and piperine by RP-UFLC method. Drug development and industrial pharmacy. 2021 Apr; 47(4):562-568. doi: 10.1080/03639045.2021.1892740. [PMID: 33648389]
Gajendra Kumar, Dharmendra Kumar, Netra Pal Singh. Therapeutic Approach against 2019-nCoV by Inhibition of ACE-2 Receptor. Drug research. 2021 Apr; 71(4):213-218. doi: 10.1055/a-1275-0228. [PMID: 33184809]
Sharna-Kay Daley, Geoffrey A Cordell. Biologically Significant and Recently Isolated Alkaloids from Endophytic Fungi. Journal of natural products. 2021 03; 84(3):871-897. doi: 10.1021/acs.jnatprod.0c01195. [PMID: 33534564]
Asha B Thomas, Durga C Choudhary, Amol Raje, Shatrughna S Nagrik. Pharmacokinetics and Pharmacodynamic Herb-Drug Interaction of Piperine with Atorvastatin in Rats. Journal of chromatographic science. 2021 Mar; 59(4):371-380. doi: 10.1093/chromsci/bmaa126. [PMID: 33434916]
Gisele Dias da Silva, Hélimar Gonçalves de Lima, Humberto Fonseca de Freitas, Samuel Silva da Rocha Pita, Yann Dos Santos Luz, Mauro Pereira de Figueiredo, Rosângela Soares Uzêda, Alexsandro Branco, Silvia Lima Costa, Maria José Moreira Batatinha, Mariana Borges Botura. In vitro and in silico studies of the larvicidal and anticholinesterase activities of berberine and piperine alkaloids on Rhipicephalus microplus. Ticks and tick-borne diseases. 2021 03; 12(2):101643. doi: 10.1016/j.ttbdis.2020.101643. [PMID: 33388555]
Xingming Hou, Congxiao Zhang, Limei Wang, KeWei Wang. Natural Piperine Improves Lipid Metabolic Profile of High-Fat Diet-Fed Mice by Upregulating SR-B1 and ABCG8 Transporters. Journal of natural products. 2021 02; 84(2):373-381. doi: 10.1021/acs.jnatprod.0c01018. [PMID: 33492139]
Prabhakar Singh, Kanti Bhooshan Pandey, Syed Ibrahim Rizvi. Piperine protects oxidative modifications in human erythrocytes. Journal of basic and clinical physiology and pharmacology. 2021 Feb; 33(2):163-167. doi: 10.1515/jbcpp-2020-0100. [PMID: 33559462]
Lipika Ray, R Karthik, Vikas Srivastava, Sheelendra Pratap Singh, A B Pant, Neena Goyal, Kailash C Gupta. Efficient antileishmanial activity of amphotericin B and piperine entrapped in enteric coated guar gum nanoparticles. Drug delivery and translational research. 2021 02; 11(1):118-130. doi: 10.1007/s13346-020-00712-9. [PMID: 32016707]
Jiu-Wang Yu, Hong-Wei Yuan, Li-Dao Bao, Leng-Ge Si. Interaction between piperine and genes associated with sciatica and its mechanism based on molecular docking technology and network pharmacology. Molecular diversity. 2021 Feb; 25(1):233-248. doi: 10.1007/s11030-020-10055-9. [PMID: 32130644]
Iahtisham-Ul Haq, Muhammad Imran, Muhammad Nadeem, Tabussam Tufail, Tanweer A Gondal, Mohammad S Mubarak. Piperine: A review of its biological effects. Phytotherapy research : PTR. 2021 Feb; 35(2):680-700. doi: 10.1002/ptr.6855. [PMID: 32929825]