3,4-Dihydroxybenzaldehyde (BioDeep_00000002890)

Main id: BioDeep_00000229764

 

human metabolite PANOMIX_OTCML-2023 blood metabolite Volatile Flavor Compounds natural product


代谢物信息卡片


protocatechualdehyde, formyl-14C-labeled

化学式: C7H6O3 (138.03169259999999)
中文名称: 3,4-二羟基苯甲醛
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=C(C=C1C=O)O)O
InChI: InChI=1S/C7H6O3/c8-4-5-1-2-6(9)7(10)3-5/h1-4,9-10H

描述信息

Protocatechualdehyde, also known as rancinamycin iv or 1,2-dihydroxy-4-formylbenzene, is a member of the class of compounds known as hydroxybenzaldehydes. Hydroxybenzaldehydes are organic aromatic compounds containing a benzene ring carrying an aldehyde group and a hydroxyl group. Protocatechualdehyde is soluble (in water) and a very weakly acidic compound (based on its pKa). Protocatechualdehyde is an almond, bitter, and dry tasting compound and can be found in a number of food items such as plains prickly pear, mugwort, silver linden, and cardamom, which makes protocatechualdehyde a potential biomarker for the consumption of these food products. Protocatechualdehyde can be found primarily in urine. This molecule can be used as a precursor in the vanillin synthesis by biotransformation by cell cultures of Capsicum frutescens, a type of Chili pepper. It is also found in the mushroom Phellinus linteus .
3,4-Dihydroxybenzaldehyde, also known as protocatechuic aldehyde, is a phenolic aldehyde, a compound released from cork stoppers into wine. This molecule can be used as a precursor in vanillin synthesis via biotransformation by cell cultures of Capsicum frutescens, a type of chili pepper. It is also found in the mushroom Phellinus linteus (Wikipedia).
D006401 - Hematologic Agents > D000925 - Anticoagulants
Protocatechualdehyde (Catechaldehyde), a natural polyphenol compound isolated from the roots of radix Salviae Miltiorrhizae, is associated with a wide variety of biological activities and has been widely used in medicine as an antioxidant, anti-aging, an antibacterial and anti-inflammatory agent[1].
Protocatechualdehyde (Catechaldehyde), a natural polyphenol compound isolated from the roots of radix Salviae Miltiorrhizae, is associated with a wide variety of biological activities and has been widely used in medicine as an antioxidant, anti-aging, an antibacterial and anti-inflammatory agent[1].

同义名列表

13 个代谢物同义名

protocatechualdehyde, formyl-14C-labeled; protocatechualdehyde, 3H-labeled; 4-Formyl-1,2-dihydroxybenzene; 1,2-Dihydroxy-4-formylbenzene; 3,4-Dihydroxybenzenecarbonal; 3,4-dihydroxybenzaldehyde; 4-Formyl-1,2-benzenediol; protocatechuic aldehyde; Protocatechualdehyde; rancinamycin IV; catechaldehyde; 3,4-Dihydroxybenzaldehyde; 3,4-Dihydroxybenzaldehyde



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

245 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Lei Zhang, Yuan Li, Wenqing Yang, Lin Lin, Jie Li, Dekun Liu, Chao Li, Jibiao Wu, Yunlun Li. Protocatechuic aldehyde increases pericyte coverage and mitigates pericyte damage to enhance the atherosclerotic plaque stability. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Dec; 168(?):115742. doi: 10.1016/j.biopha.2023.115742. [PMID: 37871558]
  • Yangjing Bai, Shiying Lang, Yangrui Du, Qinsheng Hu, Xinyun Li, Gongyan Liu. Metallic-Polyphenolic Nanoparticles Reinforced Cationic Guar Gum Hydrogel for Effectively Treating Burn Wound. Macromolecular bioscience. 2023 Oct; ?(?):e2300396. doi: 10.1002/mabi.202300396. [PMID: 37831011]
  • Shao-Ru Wu, Wei-Hong Feng, Kai-Ming Chen, Liang-Jun Guan, Liang-Mian Chen, Zhi-Min Wang, Hui-Min Gao, Zong-Hua Song. [Chemical composition and antioxidant activity of different parts of Prunella vulgaris by UPLC-Q-TOF-MS/MS and UPLC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Sep; 48(17):4569-4588. doi: 10.19540/j.cnki.cjcmm.20221227.202. [PMID: 37802797]
  • Chunliu Wang, Jie Zhou, Shixiang Wang, Yang Liu, Kaihua Long, Tingting Sun, Wenbing Zhi, Yang Yang, Hong Zhang, Ye Zhao, Xiaopu Zheng, Xiaohui Zheng, Ye Li, Pu Jia. Guanxining injection alleviates fibrosis in heart failure mice and regulates SLC7A11/GPX4 axis. Journal of ethnopharmacology. 2023 Jun; 310(?):116367. doi: 10.1016/j.jep.2023.116367. [PMID: 36914037]
  • Junxia Pei, Zhou Su, Xin Zeng, Ya Zhong, Yamei Zhang, Yixi Yang, Qiuxia Lu, Jian Li, Yu Deng. Protocatechuic aldehyde acts synergistically with dacarbazine to augment DNA double-strand breaks and promote apoptosis in cutaneous melanoma cells. BMC complementary medicine and therapies. 2023 Apr; 23(1):111. doi: 10.1186/s12906-023-03933-w. [PMID: 37024907]
  • Pengjun Wang, Qingxiang Zhang. Protocatechuic aldehyde alleviates D-galactose-induced cardiomyocyte senescence by regulating the TCF3 / ATG5 axis. Journal of cardiovascular pharmacology. 2022 Dec; ?(?):. doi: 10.1097/fjc.0000000000001394. [PMID: 36651950]
  • Xin-Yu Lin, Jing Zhou, Cai-Feng Hao, He Zhu, Shan-Shan Zhou, Jin-Di Xu, Qian Mao, Song-Lin Li, Ming Kong. Quality consistency evaluation of commercial Prunellae Spica by integrating determination of secondary metabolites and saccharides. Phytochemical analysis : PCA. 2022 Dec; ?(?):. doi: 10.1002/pca.3197. [PMID: 36494085]
  • Yu-Teng Chang, Mu-Chi Chung, Chi-Hao Chang, Kuan-Hsun Chiu, Jeng-Jer Shieh, Ming-Ju Wu. Anti-EMT and anti-fibrosis effects of protocatechuic aldehyde in renal proximal tubular cells and the unilateral ureteral obstruction animal model. Pharmaceutical biology. 2022 Dec; 60(1):1198-1206. doi: 10.1080/13880209.2022.2088809. [PMID: 35758295]
  • Nikhil Maheshwari, Riaz Mahmood. 3,4-Dihydroxybenzaldehyde attenuates pentachlorophenol-induced cytotoxicity, DNA damage and collapse of mitochondrial membrane potential in isolated human blood cells. Drug and chemical toxicology. 2022 May; 45(3):1225-1242. doi: 10.1080/01480545.2020.1811722. [PMID: 32854525]
  • Eun-A Kim, Eui-Jeong Han, Junseong Kim, Ilekuttige Priyan Shanura Fernando, Jae-Young Oh, Kil-Nam Kim, Ginnae Ahn, Soo-Jin Heo. Anti-Allergic Effect of 3,4-Dihydroxybenzaldehyde Isolated from Polysiphonia morrowii in IgE/BSA-Stimulated Mast Cells and a Passive Cutaneous Anaphylaxis Mouse Model. Marine drugs. 2022 Feb; 20(2):. doi: 10.3390/md20020133. [PMID: 35200662]
  • Yan Guo, Jie-Hong Yang, Yu He, Hui-Fen Zhou, Yu Wang, Zhi-Shan Ding, Bo Jin, Hai-Tong Wan. Protocatechuic aldehyde prevents ischemic injury by attenuating brain microvascular endothelial cell pyroptosis via lncRNA Xist. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jan; 94(?):153849. doi: 10.1016/j.phymed.2021.153849. [PMID: 34775360]
  • Ruhi Anjum, Nikhil Maheshwari, Riaz Mahmood. 3,4-Dihydroxybenzaldehyde mitigates fluoride-induced cytotoxicity and oxidative damage in human RBC. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 2022 Jan; 69(?):126888. doi: 10.1016/j.jtemb.2021.126888. [PMID: 34773916]
  • Yu-Teng Chang, Mu-Chi Chung, Chang-Chi Hsieh, Jeng-Jer Shieh, Ming-Ju Wu. Evaluation of the Therapeutic Effects of Protocatechuic Aldehyde in Diabetic Nephropathy. Toxins. 2021 08; 13(8):. doi: 10.3390/toxins13080560. [PMID: 34437430]
  • Tao Tian, Guo-Ying Chen, Hao Zhang, Feng-Qing Yang. Personal Glucose Meter for α-Glucosidase Inhibitor Screening Based on the Hydrolysis of Maltose. Molecules (Basel, Switzerland). 2021 Jul; 26(15):. doi: 10.3390/molecules26154638. [PMID: 34361791]
  • Brahmam Kapalavavi, Ninad Doctor, Baohong Zhang, Yu Yang. Subcritical Water Extraction of Salvia miltiorrhiza. Molecules (Basel, Switzerland). 2021 Mar; 26(6):. doi: 10.3390/molecules26061634. [PMID: 33804141]
  • Jieke Yang, Jianchun Li, Ruizhi Tan, Xingcan He, Xiao Lin, Xia Zhong, Junming Fan, Li Wang. Protocatechualdehyde attenuates obstructive nephropathy through inhibiting lncRNA9884 induced inflammation. Phytotherapy research : PTR. 2021 Mar; 35(3):1521-1533. doi: 10.1002/ptr.6919. [PMID: 33118280]
  • Yan-Jun Wan, Yan-Hang Wang, Qiang Guo, Yong Jiang, Peng-Fei Tu, Ke-Wu Zeng. Protocatechualdehyde protects oxygen-glucose deprivation/reoxygenation-induced myocardial injury via inhibiting PERK/ATF6α/IRE1α pathway. European journal of pharmacology. 2021 Jan; 891(?):173723. doi: 10.1016/j.ejphar.2020.173723. [PMID: 33159933]
  • Yunyun Qu, Xin Liu, Shuai Zong, Huanxin Sun, Shuang Liu, Yueran Zhao. Protocatechualdehyde Inhibits the Osteoclast Differentiation of RAW264.7 and BMM Cells by Regulating NF-κB and MAPK Activity. BioMed research international. 2021; 2021(?):6108999. doi: 10.1155/2021/6108999. [PMID: 34327232]
  • Shuang Wu, Qingyu Wang, Jinquan Wang, Baoyu Duan, Qihe Tang, Zhuojian Sun, Jinlong Han, Chenggang Shan, Zhifen Wang, Zhihui Hao. Protocatechuic aldehyde from Salvia miltiorrhiza exhibits an anti-inflammatory effect through inhibiting MAPK signalling pathway. BMC complementary medicine and therapies. 2020 Nov; 20(1):347. doi: 10.1186/s12906-020-03090-4. [PMID: 33203388]
  • Danqing Wang, Shuangshuang Zhang, Han Tang, Cuiping Jiang, Bingwei Wang, Jianping Liu. Development of sustained-release pellets to modulate the in vivo processes of the main active components of Danshen: A pharmacokinetic and pharmacodynamic evaluation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 May; 58(?):152793. doi: 10.1016/j.phymed.2018.12.016. [PMID: 31005724]
  • Aparna Singh, Marie-Ange Massicotte, Ariane Garand, Laurence Tousignant, Vincent Ouellette, Gervais Bérubé, Isabel Desgagné-Penix. Cloning and characterization of norbelladine synthase catalyzing the first committed reaction in Amaryllidaceae alkaloid biosynthesis. BMC plant biology. 2018 Dec; 18(1):338. doi: 10.1186/s12870-018-1570-4. [PMID: 30526483]
  • Nazim Husain, Riaz Mahmood. 3,4-Dihydroxybenzaldehyde quenches ROS and RNS and protects human blood cells from Cr(VI)-induced cytotoxicity and genotoxicity. Toxicology in vitro : an international journal published in association with BIBRA. 2018 Aug; 50(?):293-304. doi: 10.1016/j.tiv.2018.04.004. [PMID: 29665407]
  • Bin Sun, Peng Wang, Ren Wang, Yikui Li, Sheng Xu. Molecular Cloning and Characterization of a meta/para-O-Methyltransferase from Lycoris aurea. International journal of molecular sciences. 2018 06; 19(7):. doi: 10.3390/ijms19071911. [PMID: 29966257]
  • Nikhil Maheshwari, Fahim Halim Khan, Riaz Mahmood. 3,4-Dihydroxybenzaldehyde lowers ROS generation and protects human red blood cells from arsenic(III) induced oxidative damage. Environmental toxicology. 2018 May; ?(?):. doi: 10.1002/tox.22572. [PMID: 29732668]
  • Ajing Zhao, Li Zhang, Rong Li, Jiao Shang, Huihui Yi, Yuan Wang, Dian Zhang, Shixiang Wang, Minfeng Fang. Development and validation of an LC-MS/MS method for the simultaneous quantification of seven constituents in rat plasma and application in a pharmacokinetic study of the Zaoren Anshen prescription. Biomedical chromatography : BMC. 2018 Feb; 32(2):. doi: 10.1002/bmc.4055. [PMID: 28744886]
  • Lin Zhang, Huiying Xu, Libin Zhan. Pharmacokinetic Assessments of Liquiritin, Protocatechuic Aldehyde and Rosmarinic Acid in Rat Plasma by UPLC-MS-MS After Administration of ZibuPiyin Recipe. Journal of chromatographic science. 2018 Feb; 56(2):139-146. doi: 10.1093/chromsci/bmx093. [PMID: 29186346]
  • Tsung-Ting Shih, Hui-Ling Lee, Show-Chuen Chen, Chih-Yuan Kang, Ren-Shang Shen, Yi-An Su. Rapid analysis of traditional Chinese medicine Pinellia ternata by microchip electrophoresis with electrochemical detection. Journal of separation science. 2018 Feb; 41(3):740-746. doi: 10.1002/jssc.201700901. [PMID: 29152857]
  • Jing Zhou, Min Li, Weifeng Jin, Xiaohong Li, Hongjin Fan, Yuyan Zhang. Pharmacokinetic Study on Protocatechuic Aldehyde and Hydroxysafflor Yellow A of Danhong Injection in Rats with Hyperlipidemia. Pharmacology. 2018; 102(3-4):154-160. doi: 10.1159/000491020. [PMID: 30045035]
  • Wei Li, Hongjie Zhou, Yang Chu, Xiangyang Wang, Ruizhi Luo, Liu Yang, Navaneethakrishnan Polachi, Xiao Li, Min Chen, Luqi Huang, Xueying Yan, Zhixin Guo, He Sun. Simultaneous determination and pharmacokinetics of danshensu, protocatechuic aldehyde, 4-hydroxy-3-methyloxyphenyl lactic acid and protocatechuic acid in human plasma by LC-MS/MS after oral administration of Compound Danshen Dripping Pills. Journal of pharmaceutical and biomedical analysis. 2017 Oct; 145(?):860-864. doi: 10.1016/j.jpba.2017.06.014. [PMID: 28830061]
  • Yan Song, Lan Pan, Wenjie Li, Yingying Si, Di Zhou, Chengjian Zheng, Xiaofang Hao, Xinyue Jia, Yuemei Jia, Minghui Shi, Xiaoguang Jia, Ning Li, Yue Hou. Natural neuro-inflammatory inhibitors from Caragana turfanensis. Bioorganic & medicinal chemistry letters. 2017 10; 27(20):4765-4769. doi: 10.1016/j.bmcl.2017.08.047. [PMID: 28911817]
  • Wei-Jun Kong, Shan-Shan Zhang, Yan-Ling Zhao, Ming-Quan Wu, Ping Chen, Xiao-Ru Wu, Xin-Ping Ma, Wei-Ying Guo, Mei-Hua Yang. Combination of chemical fingerprint and bioactivity evaluation to explore the antibacterial components of Salvia miltiorrhizae. Scientific reports. 2017 08; 7(1):8112. doi: 10.1038/s41598-017-08377-0. [PMID: 28808259]
  • Yaping Shao, Wen Zhang, Ling Tong, Jingyi Huang, Dongxiang Li, Wei Nie, Yan Zhu, Yunfei Li, Tao Lu. Simultaneous determination of eight bioactive components of Qishen Yiqi dripping pills in rat plasma using UFLC-MS/MS and its application to a pharmacokinetic study. Biomedical chromatography : BMC. 2017 Aug; 31(8):. doi: 10.1002/bmc.3941. [PMID: 28146302]
  • Hong-Jing Fan, Li Yu, Wei-Feng Jin, Min Li, Jing Zhou, Xiao-Hong Li, Yu-Yan Zhang. [Pharmacokinetics-pharmacodynamics correlation of protocatechuic aldehyde and hydroxysafflor yellow A alone or their combination use in rats with hyperlipidemia]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2017 Jul; 42(13):2564-2570. doi: 10.19540/j.cnki.cjcmm.20170523.008. [PMID: 28840700]
  • Tingyang Li, Yang Chu, Kaijing Yan, Shuming Li, Xiangyang Wang, Ying Wang, Wei Li, Xiaohui Ma, Jin Yang, Changxiao Liu. Simultaneous determination of tanshinol, protocatechuic aldehyde, protocatechuic acid, notoginsenoside R1, ginsenoside Rg1 and Rb1 in rat plasma by LC-MS/MS and its application. Biomedical chromatography : BMC. 2017 Jun; 31(6):. doi: 10.1002/bmc.3889. [PMID: 28164352]
  • Di Zhou, Hongyan Wei, Zhe Jiang, Xuezheng Li, Kun Jiao, Xiaoguang Jia, Yue Hou, Ning Li. Natural potential neuroinflammatory inhibitors from Alhagi sparsifolia Shap. Bioorganic & medicinal chemistry letters. 2017 02; 27(4):973-978. doi: 10.1016/j.bmcl.2016.12.075. [PMID: 28073678]
  • Shuangshuang Zhang, Hongxiang Yan, Panpan Yu, Yulong Xia, Wenli Zhang, Jianping Liu. Development of protocatechualdehyde proliposomes-based sustained-release pellets with improved bioavailability and desired pharmacokinetic behavior for angina chronotherapy. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2016 Oct; 93(?):341-50. doi: 10.1016/j.ejps.2016.08.040. [PMID: 27568854]
  • Zhanli Liu, Xunyang Zheng, Yanlei Guo, Weihan Qin, Lei Hua, Yong Yang. Quantitatively metabolic profiles of salvianolic acids in rats after gastric-administration of Salvia miltiorrhiza extract. Fitoterapia. 2016 Sep; 113(?):27-34. doi: 10.1016/j.fitote.2016.06.017. [PMID: 27370098]
  • Jung Woo Byun, Sena Hwang, Chan Woo Kang, Jin Hee Kim, Min Kyung Chae, Jin Sook Yoon, Eun Jig Lee. Therapeutic Effect of Protocatechuic Aldehyde in an In Vitro Model of Graves' Orbitopathy. Investigative ophthalmology & visual science. 2016 08; 57(10):4055-62. doi: 10.1167/iovs.15-19037. [PMID: 27494347]
  • Kai Liang, Shuiting Zhai, Zhidong Zhang, Guoquan Wang, Xiaoyang Fu, Tianxiao Li. Study on the small intestine absorptive kinetics characters of tanshinol and protocatechualdehyde of Salvia miltiorrhiza extracts in rats in vivo. Pakistan journal of pharmaceutical sciences. 2016 Jul; 29(4 Suppl):1415-20. doi: . [PMID: 27592492]
  • Hao Ren, Dawei Qian, Shulan Su, Hanliang Guan, Wei Zhang, Erxin Shang, Jinao Duan. Simultaneous determination of tanshinones and polyphenolics in rat plasma by UPLC-MS/MS and its application to the pharmacokinetic interaction between them. Drug testing and analysis. 2016 Jul; 8(7):744-54. doi: 10.1002/dta.1840. [PMID: 26382027]
  • Shili Li, Yanmei Yu, Juanni Chen, Bing Guo, Liang Yang, Wei Ding. Evaluation of the Antibacterial Effects and Mechanism of Action of Protocatechualdehyde against Ralstonia solanacearum. Molecules (Basel, Switzerland). 2016 Jun; 21(6):. doi: 10.3390/molecules21060754. [PMID: 27294898]
  • Md Iqbal Alam, Mohammed A Alam, Ozair Alam, Amit Nargotra, Subhash Chandra Taneja, Surrinder Koul. Molecular modeling and snake venom phospholipase A2 inhibition by phenolic compounds: Structure-activity relationship. European journal of medicinal chemistry. 2016 May; 114(?):209-19. doi: 10.1016/j.ejmech.2016.03.008. [PMID: 26986086]
  • Xiangyang Wang, Kaijing Yan, Xiaohui Ma, Wei Li, Yang Chu, Jiahua Guo, Shuming Li, Shuiping Zhou, Yonghong Zhu, Changxiao Liu. Simultaneous Determination and Pharmacokinetic Study of Protocatechuic Aldehyde and Its Major Active Metabolite Protocatechuic Acid in Rat Plasma by Liquid Chromatography-Tandem Mass Spectrometry. Journal of chromatographic science. 2016 May; 54(5):697-705. doi: 10.1093/chromsci/bmv240. [PMID: 26969682]
  • Zheng-yi Qu, Yu-wei Zhang, Si-Wen Zheng, Chun-lin Yao, Yin-ping Jin, Pei-he Zheng, Cheng-he Sun, Ying-ping Wang. A new phenylethanoid glycoside from Orobanche cernua Loefling. Natural product research. 2016; 30(8):948-53. doi: 10.1080/14786419.2015.1084305. [PMID: 26358786]
  • Monica R Loizzo, Deborah Pacetti, Paolo Lucci, Oscar Núñez, Francesco Menichini, Natale Giuseppe Frega, Rosa Tundis. Prunus persica var. platycarpa (Tabacchiera Peach): Bioactive Compounds and Antioxidant Activity of Pulp, Peel and Seed Ethanolic Extracts. Plant foods for human nutrition (Dordrecht, Netherlands). 2015 Sep; 70(3):331-7. doi: 10.1007/s11130-015-0498-1. [PMID: 26138775]
  • Lin Zheng, Zipeng Gong, Yuan Lu, Yumin Xie, Yong Huang, Yue Liu, Yanyu Lan, Aimin Wang, Yonglin Wang. A UPLC-MS/MS method for simultaneous determination of danshensu, protocatechuic aldehyde, rosmarinic acid, and ligustrazine in rat plasma, and its application to pharmacokinetic studies of Shenxiong glucose injection in rats. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2015 Aug; 997(?):210-7. doi: 10.1016/j.jchromb.2015.06.008. [PMID: 26118621]
  • Didier Froissard, Sylvie Rapior, Jean-Marie Bessière, Bruno Buatois, Alain Fruchier, Vincent Sol, Françoise Fons. Asplenioideae Species as a Reservoir of Volatile Organic Compounds with Potential Therapeutic Properties. Natural product communications. 2015 Jun; 10(6):1079-83. doi: . [PMID: 26197556]
  • Hongli Luo, Weijun Kong, Yichen Hu, Ping Chen, Xiaoru Wu, Li Wan, Meihua Yang. Quality evaluation of Salvia miltiorrhiza Bge. by ultra high performance liquid chromatography with photodiode array detection and chemical fingerprinting coupled with chemometric analysis. Journal of separation science. 2015 May; 38(9):1544-51. doi: 10.1002/jssc.201401430. [PMID: 25708915]
  • Verónica Calcatierra, Óscar López, José G Fernández-Bolaños, Gabriela B Plata, José M Padrón. Phenolic thio- and selenosemicarbazones as multi-target drugs. European journal of medicinal chemistry. 2015 Apr; 94(?):63-72. doi: 10.1016/j.ejmech.2015.02.037. [PMID: 25752525]
  • Lin Zhou, Yuan-Bo Li, Yu Yuan, Mei Dai, Bo Huang, Ai-Jun Zhang. Study of the in vitro-in vivo correlation of Danshensu and protocatechuic aldehyde in a two-step release system. Journal of Asian natural products research. 2015; 17(4):391-402. doi: 10.1080/10286020.2014.1003813. [PMID: 25631212]
  • Sheng-Min Liu, Zhi-Hong Yang, Xiao-Bo Sun. [Simultaneous determination of six Salvia miltiorrhiza gradients in rat plasma and brain by LC-MS/MS]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2014 May; 39(9):1704-8. doi: . [PMID: 25095388]
  • Zhang-wei Wang, Xiang-hong Xu, Xiao-tian Chen, Shi-shan Yu, Hong-dong Liu, Toshimitsu Hayashi, Bin Li. [Chemical constituents from the aerial part of Sibiraea angustata]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2014 Jan; 37(1):57-60. doi: ". [PMID: 25090704]
  • Jian-Ming Lü, Qizhi Yao, Changyi Chen. 3,4-Dihydroxy-5-nitrobenzaldehyde (DHNB) is a potent inhibitor of xanthine oxidase: a potential therapeutic agent for treatment of hyperuricemia and gout. Biochemical pharmacology. 2013 Nov; 86(9):1328-37. doi: 10.1016/j.bcp.2013.08.011. [PMID: 23994369]
  • Jian-ping Zhang, Yuan-yuan Zhang, Ying Zhang, Yong-gang Gao, Juan-juan Ma, Na Wang, Jiang-yan Wang, Yun Xie, Feng-hua Zhang, Li Chu. Salvia miltiorrhiza (Danshen) injection ameliorates iron overload-induced cardiac damage in mice. Planta medica. 2013 Jun; 79(9):744-52. doi: 10.1055/s-0032-1328588. [PMID: 23700113]
  • Pierluigi Caboni, Nadhem Aissani, Tiziana Cabras, Andrea Falqui, Roberto Marotta, Barbara Liori, Nikoletta Ntalli, Giorgia Sarais, Nicola Sasanelli, Graziella Tocco. Potent nematicidal activity of phthalaldehyde, salicylaldehyde, and cinnamic aldehyde against Meloidogyne incognita. Journal of agricultural and food chemistry. 2013 Feb; 61(8):1794-803. doi: 10.1021/jf305164m. [PMID: 23379671]
  • Jun Chen, Jian-Hua Wei, Shao-Fang Cai, Wei-Sheng Miao, Li-Wei Pan. [Study on chemical constituents of Cardiospermum halicacabum]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2013 Feb; 36(2):228-30. doi: . [PMID: 23901648]
  • Yuzo Nakagawa-Yagi, Yukiko Sato, Emi Matsumoto, Shin-Ichi Nakatsuka, Tsuyoshi Sakaki, Yukiko Muramatsu, Takaaki Hara, Toshiro Aigaki. Pharmacological modulation of histone demethylase activity by a small molecule isolated from subcritical water extracts of Sasa senanensis leaves prolongs the lifespan of Drosophila melanogaster. BMC complementary and alternative medicine. 2012 Jul; 12(?):101. doi: 10.1186/1472-6882-12-101. [PMID: 22809229]
  • Shanshan Zeng, Lu Wang, Teng Chen, Yuefei Wang, Huanbiao Mo, Haibin Qu. Direct analysis in real time mass spectrometry and multivariate data analysis: a novel approach to rapid identification of analytical markers for quality control of traditional Chinese medicine preparation. Analytica chimica acta. 2012 Jul; 733(?):38-47. doi: 10.1016/j.aca.2012.04.025. [PMID: 22704374]
  • Guiwu Qu, Xidian Yue, Fengshan An, Shengjun Dai, Guisheng Li, Bafang Li. [Chemical constituents contained in Salvia castanea]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Jul; 37(13):1985-9. doi: . [PMID: 23019884]
  • Chang Yoon Moon, Cheol Ryong Ku, Yoon Hee Cho, Eun Jig Lee. Protocatechuic aldehyde inhibits migration and proliferation of vascular smooth muscle cells and intravascular thrombosis. Biochemical and biophysical research communications. 2012 Jun; 423(1):116-21. doi: 10.1016/j.bbrc.2012.05.092. [PMID: 22640742]
  • Yufeng Zhang, Peiying Shi, Hong Yao, Qing Shao, Xiaohui Fan. Metabolite profiling and pharmacokinetics of herbal compounds following oral administration of a cardiovascular multi-herb medicine (Qishen yiqi pills) in rats. Current drug metabolism. 2012 Jun; 13(5):510-23. doi: 10.2174/1389200211209050510. [PMID: 22292791]
  • Yong Xu, Wang-Lin Jiang, Shu-Ping Zhang, Hai-Bo Zhu, Jian Hou. Protocatechuic aldehyde protects against experimental sepsis in vitro and in vivo. Basic & clinical pharmacology & toxicology. 2012 Apr; 110(4):384-9. doi: 10.1111/j.1742-7843.2011.00827.x. [PMID: 22050905]
  • Yunfei Chen, Shoujin Liu, Fei Wang. [Sesquiterpenoids of Coniogramme maxima]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Apr; 37(7):946-50. doi: ". [PMID: 22792795]
  • Jian-Shuang Jiang, Zhi-Lai Zhan, Zi-Ming Feng, Ya-Nan Yang, Pei-Cheng Zhang. [Study on the chemical constituents from Cyathea spinulosa]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2012 Apr; 35(4):568-70. doi: ". [PMID: 23019903]
  • Ming Ruan, Yi Li, Xin Li, Jianguang Luo, Lingyi Kong. Qualitative and quantitative analysis of the major constituents in Chinese medicinal preparation Guan-Xin-Ning injection by HPLC-DAD-ESI-MS(n). Journal of pharmaceutical and biomedical analysis. 2012 Feb; 59(?):184-9. doi: 10.1016/j.jpba.2011.10.007. [PMID: 22071444]
  • Md Sarfaraj Hussain, Sheeba Fareed, Saba Ansari, Md Akhlaquer Rahman, Iffat Zareen Ahmad, Mohd Saeed. Current approaches toward production of secondary plant metabolites. Journal of pharmacy & bioallied sciences. 2012 Jan; 4(1):10-20. doi: 10.4103/0975-7406.92725. [PMID: 22368394]
  • Mengyue Wang, Ke Li, Yuxiao Nie, Yingfang Wei, Xiaobo Li. Antirheumatoid Arthritis Activities and Chemical Compositions of Phenolic Compounds-Rich Fraction from Urtica atrichocaulis, an Endemic Plant to China. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):818230. doi: 10.1155/2012/818230. [PMID: 21904564]
  • Hua Li, Si-Wang Wang, Bang-Le Zhang, Yan-Hua Xie, Qian Yang, Wei Cao, Jian-Bo Wang. Simultaneous quantitative determination of 9 active components in traditional Chinese medicinal preparation ShuangDan oral liquid by RP-HPLC coupled with photodiode array detection. Journal of pharmaceutical and biomedical analysis. 2011 Dec; 56(4):820-4. doi: 10.1016/j.jpba.2011.07.016. [PMID: 21821374]
  • Farid Khallouki, Roswitha Haubner, Cornelia M Ulrich, Robert W Owen. Ethnobotanical survey, chemical composition, and antioxidant capacity of methanolic extract of the root bark of Annona cuneata Oliv. Journal of medicinal food. 2011 Nov; 14(11):1397-402. doi: 10.1089/jmf.2010.0228. [PMID: 21870939]
  • Yi Wang, Xiaoping Zhao, Xiumei Gao, Xiaojing Nie, Yingxin Yang, Xiaohui Fan. Development of fluorescence imaging-based assay for screening cardioprotective compounds from medicinal plants. Analytica chimica acta. 2011 Sep; 702(1):87-94. doi: 10.1016/j.aca.2011.06.020. [PMID: 21819864]
  • Jae B Park. Identification and quantification of a major anti-oxidant and anti-inflammatory phenolic compound found in basil, lemon thyme, mint, oregano, rosemary, sage, and thyme. International journal of food sciences and nutrition. 2011 Sep; 62(6):577-84. doi: 10.3109/09637486.2011.562882. [PMID: 21506887]
  • Thomas Widiez, Thomas G Hartman, Nativ Dudai, Qing Yan, Michael Lawton, Daphna Havkin-Frenkel, Faith C Belanger. Functional characterization of two new members of the caffeoyl CoA O-methyltransferase-like gene family from Vanilla planifolia reveals a new class of plastid-localized O-methyltransferases. Plant molecular biology. 2011 Aug; 76(6):475-88. doi: 10.1007/s11103-011-9772-2. [PMID: 21629984]
  • Yuqin Li, Yingjie Cui, Xiaoming Zhao, Baoxiu Jia, Yongxiu Qi. [Capillary electrophoresis with field-enhanced stacking for determination of water-soluble active principles in Salvia miltiorrhiza var. miltiorrhiza f. alba]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Jun; 36(11):1466-70. doi: 10.4268/cjcmm20111113. [PMID: 22779179]
  • Ya-He Liu, Sui-Lin Mo, Hui-Chang Bi, Bing-Fang Hu, Chun Guang Li, Yi-Tao Wang, Ling Huang, Min Huang, Wei Duan, Jun-Ping Liu, Ming Qian Wei, Shu-Feng Zhou. Regulation of human pregnane X receptor and its target gene cytochrome P450 3A4 by Chinese herbal compounds and a molecular docking study. Xenobiotica; the fate of foreign compounds in biological systems. 2011 Apr; 41(4):259-80. doi: 10.3109/00498254.2010.537395. [PMID: 21117944]
  • Zhijuan Gao, Bo Sang, Yangjing Liang, Shixiang Wang, Jie Yu, Xiaohui Zheng. [Pharmacokinetics of three phenolic acids of xiangdan injection in rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Apr; 36(7):922-5. doi: 10.4268/cjcmm20110722. [PMID: 21761736]
  • Yu-Ling Wang, Jiang-Feng Yuan, Wei Shang, Jing Zhang, Zhi-Qi Zhang. Dialysis sampling on-line coupled with high-performance liquid chromatography for simultaneous investigation of the interactions between multi-components in herbs and the albumin. The Analyst. 2011 Feb; 136(4):823-8. doi: 10.1039/c0an00471e. [PMID: 21127792]
  • Sze Man Wong, Po Yee Chiu, Hoi Yan Leung, Limin Zhou, Zhong Zuo, Philip Y Lam, Kam Ming Ko. Myocardial post-conditioning with Danshen-Gegen decoction protects against isoproterenol-induced myocardial injury via a PKCε/mKATP-mediated pathway in rats. Chinese medicine. 2011 Feb; 6(1):7. doi: 10.1186/1749-8546-6-7. [PMID: 21320349]
  • Yang Wang, Xi Huang, Feng Qin, Ping Ren, Zhengyan Zhu, Rong Fan, Chunhu Zhang, Hainan Zhang, Tao Tang, Juan He, Zhaoqian Liu, Honghao Zhou. A strategy for detecting optimal ratio of cardioprotection-dependent three compounds as quality control of guan-xin-er-hao formula. Journal of ethnopharmacology. 2011 Jan; 133(2):735-42. doi: 10.1016/j.jep.2010.11.006. [PMID: 21073938]
  • Jian-Wei Gao, Takuya Yamane, Hiroshi Maita, Shizuma Ishikawa, Sanae M M Iguchi-Ariga, Xiao-Ping Pu, Hiroyoshi Ariga. DJ-1-Mediated protective effect of protocatechuic aldehyde against oxidative stress in SH-SY5Y cells. Journal of pharmacological sciences. 2011; 115(1):36-44. doi: 10.1254/jphs.10271fp. [PMID: 21160133]
  • Vanisree Mulabagal, Ruby L Alexander-Lindo, David L Dewitt, Muraleedharan G Nair. Health-Beneficial Phenolic Aldehyde in Antigonon leptopus Tea. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):601249. doi: 10.1093/ecam/nep041. [PMID: 19454555]
  • Di Zhao, De-en Han, Ning Li, Yang Lu, Ting-ting Li, Suo-ye Yang, Jia-ke He, Xi-jing Chen. Simultaneous determination of six phenolic constituents of Danshen injection in rat plasma by LC-ESI-MS and its application to a pharmacokinetic study. European journal of mass spectrometry (Chichester, England). 2011; 17(4):395-403. doi: 10.1255/ejms.1137. [PMID: 22006631]
  • Jiangang Liu, Dawu Zhang, Jie Li, Jiatao Feng, Xiaoping Yang, Dazhuo Shi, Xinmiao Liang. [Effects of Salvia miltiorrhiza and Carthamus tinctorius aqueous extracts and compatibility on rat myocardial ischemic reperfusion injury]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Jan; 36(2):189-94. doi: 10.4268/cjcmm20110222. [PMID: 21506421]
  • Yeon Sil Lee, Il-Jun Kang, Moo Ho Won, Jae-Yong Lee, Jin Kyu Kim, Soon Sung Lim. Inhibition of protein tyrosine phosphatase 1beta by hispidin derivatives isolated from the fruiting body of Phellinus linteus. Natural product communications. 2010 Dec; 5(12):1927-30. doi: ". [PMID: 21299122]
  • Qian Zhang, Wenyi Kang. [Active compounds from rhizomes of Musa basjoo]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 Sep; 35(18):2424-7. doi: . [PMID: 21141492]
  • Kedan Chu, Jian Zheng, Wei Xu, Weirong Xie, Xiaoqin Zhang. [Determination of tanshinol and protocatechuic aldehyde in shenkangling granula by HPLC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 Jul; 35(13):1699-701. doi: 10.4268/cjcmm20101310. [PMID: 20862960]
  • Bo-bo Chang, Lin Zhang, Wan-wen Cao, Yuan Cao, Wen-liang Yang, Yan Wang, Yuan-cheng Chen, Xiao-quan Liu. Pharmacokinetic interactions induced by content variation of major water-soluble components of Danshen preparation in rats. Acta pharmacologica Sinica. 2010 May; 31(5):638-46. doi: 10.1038/aps.2010.27. [PMID: 20364158]
  • Souichi Nakashima, Hisashi Matsuda, Yoshimi Oda, Seikou Nakamura, Fengming Xu, Masayuki Yoshikawa. Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells. Bioorganic & medicinal chemistry. 2010 Mar; 18(6):2337-2345. doi: 10.1016/j.bmc.2010.01.046. [PMID: 20189399]
  • Baojun Xu, Sam K C Chang. Phenolic substance characterization and chemical and cell-based antioxidant activities of 11 lentils grown in the northern United States. Journal of agricultural and food chemistry. 2010 Feb; 58(3):1509-17. doi: 10.1021/jf903532y. [PMID: 20058926]
  • Mary Omwamba, Qiuhui Hu. Antioxidant activity in barley (Hordeum Vulgare L.) grains roasted in a microwave oven under conditions optimized using response surface methodology. Journal of food science. 2010 Jan; 75(1):C66-73. doi: 10.1111/j.1750-3841.2009.01426.x. [PMID: 20492152]
  • Ryszard Amarowicz, Isabell Estrella, Teresa Hernández, Montserrat Dueñas, Agnieszka Troszyńska, Agnieszka Kosińska, Ronald B Pegg. Antioxidant activity of a red lentil extract and its fractions. International journal of molecular sciences. 2009 Dec; 10(12):5513-5527. doi: 10.3390/ijms10125513. [PMID: 20054484]
  • Shun-ichi Wada, Yumiko Yasui, Harukuni Tokuda, Reiko Tanaka. Anti-tumor-initiating effects of phenolic compounds isolated from the bark of Picea jezoensis var. jezoensis. Bioorganic & medicinal chemistry. 2009 Sep; 17(17):6414-21. doi: 10.1016/j.bmc.2009.07.016. [PMID: 19646881]
  • Shuo Yan, Wenyuan Gao, Juan Wang, Tao Huang, Yu Cao. [Affects of different bioreactors in process of Salvia miltiorrhiza adventitious root culture]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2009 Aug; 34(16):2027-30. doi: ". [PMID: 19938537]
  • Hai-Yan Qin, Zhi-Rong Suo, Wen-Zhe Liu. [Dynamic changes of content of salvianolic acid in vegetative organs of Salvia miltiorrhiza]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2009 Aug; 32(8):1199-201. doi: ". [PMID: 19960940]
  • Hairong Xu, Ping Bu, Xiangming Li. [Establishment of reporter gene-based cell screening model for discovering new chemopreventive agents]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2009 Jul; 34(14):1835-9. doi: . [PMID: 19894520]
  • Ren-Liang Yan, Zhi-Gang Liu. [Isolation and characterization of polyphenols in seed of Litchi chinensis]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2009 Apr; 32(4):522-3. doi: ". [PMID: 19645237]
  • Jun Cao, Lian-Wen Qi, E-Hu Liu, Wei-Dong Zhang, Ping Li. Separation and on-line preconcentration by stacking and sweeping of charged analytes in the plant by microemulsion electrokinetic chromatography with nonionic surfactants. Journal of pharmaceutical and biomedical analysis. 2009 Feb; 49(2):475-80. doi: 10.1016/j.jpba.2008.10.016. [PMID: 19062218]
  • Xiaowei Zeng, Jun Yang, Xianzhe Yang, Dongsheng Hong, Limao Wu, Jun Yu. Effect of Guanxin No.2 decoction on gene expression in different areas of the myocardial infarcted heart of rats using microarray technology. The Journal of pharmacy and pharmacology. 2009 Feb; 61(2):213-9. doi: 10.1211/jpp/61.02.0011. [PMID: 19178769]
  • B Klejdus, J Kopecký, L Benesová, J Vacek. Solid-phase/supercritical-fluid extraction for liquid chromatography of phenolic compounds in freshwater microalgae and selected cyanobacterial species. Journal of chromatography. A. 2009 Jan; 1216(5):763-71. doi: 10.1016/j.chroma.2008.11.096. [PMID: 19111311]
  • Xi Huang, Feng Qin, Hong-Min Zhang, Hong-Bin Xiao, Long-Xin Wang, Xue-Ya Zhang, Ping Ren. Cardioprotection by Guanxin II in rats with acute myocardial infarction is related to its three compounds. Journal of ethnopharmacology. 2009 Jan; 121(2):268-73. doi: 10.1016/j.jep.2008.10.029. [PMID: 19041701]