Dioscin (BioDeep_00000000286)

natural product PANOMIX_OTCML-2023

代谢物信息卡片

化学式: C45H72O16 (868.4820112)
中文名称: 薯蓣皂苷, 薯蓣皂甙, 薯蓣皂甙
谱图信息: 最多检出来源 Viridiplantae(plant) 0.32%

分子结构信息

SMILES: CC1C2C(CC3C4CC=C5CC(CCC5(C)C4CCC23C)OC2OC(CO)C(OC3OC(C)C(O)C(O)C3OC3OC(C)C(O)C(O)C3O)C(O)C2O)OC11CCC(C)CO1
InChI: InChI=1S/C45H72O16/c1-19-9-14-45(54-18-19)20(2)30-28(61-45)16-27-25-8-7-23-15-24(10-12-43(23,5)26(25)11-13-44(27,30)6)57-41-37(53)35(51)38(29(17-46)58-41)59-42-39(34(50)32(48)22(4)56-42)60-40-36(52)33(49)31(47)21(3)55-40/h7,19-22,24-42,46-53H,8-18H2,1-6H3

描述信息

Dioscin is a spirostanyl glycoside that consists of the trisaccharide alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc attached to position 3 of diosgenin via a glycosidic linkage. It has a role as a metabolite, an antifungal agent, an antiviral agent, an antineoplastic agent, an anti-inflammatory agent, a hepatoprotective agent, an apoptosis inducer and an EC 1.14.18.1 (tyrosinase) inhibitor. It is a spirostanyl glycoside, a spiroketal, a hexacyclic triterpenoid and a trisaccharide derivative. It is functionally related to a diosgenin. It derives from a hydride of a spirostan.
Dioscin is a natural product found in Ophiopogon intermedius, Dracaena draco, and other organisms with data available.
See also: Dioscorea polystachya tuber (part of).
A spirostanyl glycoside that consists of the trisaccharide alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc attached to position 3 of diosgenin via a glycosidic linkage.
Dioscin is a member of the class of compounds known as steroidal saponins. Steroidal saponins are saponins in which the aglycone moiety is a steroid. The steroidal aglycone is usually a spirostane, furostane, spirosolane, solanidane, or curcubitacin derivative. Dioscin is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Dioscin can be found in fenugreek and yam, which makes dioscin a potential biomarker for the consumption of these food products.
[Raw Data] CBA65_Dioscin_pos_30eV.txt
[Raw Data] CBA65_Dioscin_pos_20eV.txt
[Raw Data] CBA65_Dioscin_pos_10eV.txt
[Raw Data] CBA65_Dioscin_pos_50eV.txt
[Raw Data] CBA65_Dioscin_pos_40eV.txt
Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells.
Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells.

同义名列表

37 个代谢物同义名

(2S,3R,4R,5R,6S)-2-[(2R,3S,4S,5R,6R)-4-hydroxy-2-(hydroxymethyl)-6-[(1S,2S,4S,5R,6R,7S,8R,9S,12S,13R,16S)-5,7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2-oxane]-16-yl]oxy-5-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]oxy-6-methyloxane-3,4,5-triol; .BETA.-D-GLUCOPYRANOSIDE, (3.BETA.,25R)-SPIROST-5-EN-3-YL O-6- DEOXY-ALPHA-L-MANNOPYRANOSYL-(1->2)-O-(6-DEOXY-.ALPHA.-L- MANNOPYRANOSYL-(1->4))-; (3.BETA.,25R)-SPIROST-5-EN-3-YL O-6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL-(1->2)-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL-(1->4))-.BETA.-D-GLUCOPYRANOSIDE; beta-D-GLUCOPYRANOSIDE, (3beta,25R)-SPIROST-5-EN-3-YL O-6-DEOXY-ALPHA-L-MANNOPYRANOSYL-(1->2)-O-(6-DEOXY-alpha-L-MANNOPYRANOSYL-(1->4))-; (3beta,25R)-SPIROST-5-EN-3-YL O-6-DEOXY-alpha-L-MANNOPYRANOSYL-(1->2)-O-(6-DEOXY-alpha-L-MANNOPYRANOSYL-(1->4))-beta-D-GLUCOPYRANOSIDE; beta-D-Glucopyranoside, (3beta,25R)-spirost-5-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1-2)-O-(6-deoxy-alpha-L-mannopyranosyl-(1-4))-; [(25R)-Spirost-5-en-3beta-yl]2-O-(6-deoxy-alpha-L-mannopyranosyl)-4-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside; (25R)-spirost-5-en-3beta-yl alpha-L-rhamnopyranosyl-(1->2)-[alpha-L-mannopyranosyl-(1->4)]-beta-D-glucopyranoside; (25R)-spirost-5-en-3beta-yl alpha-L-rhamnopyranosyl-(1->2)-(alpha-L-mannopyranosyl-(1->4))-beta-D-glucopyranoside; DIOSGENIN 3-O-.ALPHA.-L-RHAMNOPYRANOSYL-(1->2)-(.ALPHA.-L-RHAMNOPYRANOSYL-(1->4))-.BETA.-D-GLUCOPYRANOSIDE; 3-O-beta-D-alpha-L-Rhamnopyranosyl(1->4)-[alpha-L-rhamnopyranosyl(1->2)]-beta-D-glucopyranoside-diosgenin; DIOSGENIN 3-O-alpha-L-RHAMNOPYRANOSYL-(1->2)-(alpha-L-RHAMNOPYRANOSYL-(1->4))-beta-D-GLUCOPYRANOSIDE; (25r)-3beta-[2-O,4-O-bis(alpha-l-rhamnopyranosyl)-beta-d-glucopyranosyloxy]spirosta-5-ene; Diosgenin bis-alpha-L-rhamnopyranosyl)-(1-2 and 1-4)-beta-D-glucopyranoside; 3-O-(alpha-L-Rhap-(1->4)-(alpha-L-Rhap-(1->2))-beta-D-Glcp)-diosgenin; 3-O-[alpha-L-Rhap-(1->4)-[alpha-L-Rhap-(1->2)]-beta-D-Glcp]-diosgenin; 3-O-[alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc]-diosgenin; 3-O-(alpha-L-Rha-(1->4)-(alpha-L-Rha-(1->2))-beta-D-Glc)-diosgenin; 3-O-[alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc]diosgenin; 3-O-(alpha-L-Rha-(1->4)-(alpha-L-Rha-(1->2))-beta-D-Glc)diosgenin; 3-O-(Rhaalpha1-4(Rhaalpha1-2)Glcbeta)-(25R)-spirost-5-en-3beta-ol; 3-O-(Rhaa1-4(Rhaa1-2)Glcb)-(25R)-spirost-5-en-3beta-ol; Dioscin (Collettiside III); Dioscin, >=95\\% (HPLC); Collettinside III; Collettiside III; DIOSCIN [WHO-DD]; UNII-3B95U4OLWV; DIOSCIN [MI]; (+)-DIOSCIN; 3B95U4OLWV; PARIS III; Dioscine; Dioscin; Dioscin(Collettiside III); DTXSID20975887; CCRIS 4123

数据库引用编号

29 个数据库交叉引用编号

ChEBI: CHEBI:74023
KEGG: C08897
PubChem: 52931449
PubChem: 119245
PubChem: 74193140
PubChem: 271916
Metlin: METLIN67253
ChEMBL: CHEMBL507001
LipidMAPS: LMST01080053
MeSH: dioscin
ChemIDplus: 0019057604
KNApSAcK: C00003575
foodb: FDB000366
chemspider: 23089582
CAS: 19057-60-4
MoNA: CCMSLIB00005723981
MoNA: FIO00893
MoNA: FIO00892
MoNA: FIO00890
MoNA: FIO00891
MoNA: FIO00889
medchemexpress: HY-N0124
PMhub: MS000090553
PMhub: MS000038865
PMhub: MS000013843
MetaboLights: MTBLC74023
PubChem: 11090
3DMET: B02505
NIKKAJI: J15.520I

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

125 个相关的物种来源信息

33090 土茯苓: -
33090 菝葜: -
64700 Dioscorea nipponica:
4631 Costus: 10.1021/NP9702190
145674 Borassus: 10.1248/CPB.55.308
49674 Trillium: 10.1016/J.PHYTOCHEM.2008.08.004
64475 Dioscorea tokoro:
49657 Smilax china: 10.1016/J.FOODCHEM.2012.03.003
115514 Rhapis excelsa: 10.1248/CPB.32.4003
29657 Rhapis humilis: 10.1248/CPB.32.4003
329239 Hellenia lacera: 10.4268/CJCMM20111611
78534 Trigonella foenum-graecum: 10.1016/J.JPBA.2012.11.005
221254 Paris polyphylla var. chinensis:
100532 Dracaena draco:
374975 Dioscorea composita:
210369 Tribulus terrestris:
14027 Trachycarpus fortunei: 10.1248/CPB.32.295
54446 Chamaerops humilis: 10.1248/CPB.34.82
2654448 Dioscorea pseudojaponica:
158496 Triteleia hyacinthina: 10.1016/0031-9422(94)00790-Z
394307 Dioscorea spongiosa:
261420 Polygonatum kingianum: 10.1002/HLCA.200900308
4681 Allium ampeloprasum:
49657 Smilax china:
328752 Costus afer: 10.1021/NP9702190
145675 Borassus flabellifer: 10.1248/CPB.55.308
593754 Dracaena cochinchinensis: 10.1016/J.STEROIDS.2003.11.004
120020 Ypsilandra thibetica: 10.1016/J.STEROIDS.2009.07.001
50545 Trillium erectum:
1280193 Dracaena concinna: 10.1016/S0031-9422(97)00717-6
330167 Dioscorea villosa:
374971 Dioscorea futschauensis:
325984 Dioscorea zingiberensis:
1678672 Dioscorea saxatilis:
374974 Dioscorea sinoparviflora:
336258 Dioscorea panthaica:
930788 Dioscorea parviflora:
55634 Dioscorea communis:
240449 Urochloa decumbens: 10.1590/S0103-50532002000200002
64700 Dioscorea nipponica:
1280246 Sansevieria ehrenbergii: 10.1021/NP040203R
100504 Ophiopogon intermedius: 10.1016/0031-9422(88)80058-X
357959 Dioscorea collettii:
108051 Clintonia udensis: 10.1271/BBB.80003
1045158 Smilax menispermoidea:
261427 Polygonatum zanlanscianense:
143782 Dioscorea mexicana: 10.3109/13880209109082872
1632803 Melilotus tauricus: 10.1007/BF00630610
1045152 Smilax lebrunii: 10.1016/0031-9422(93)85048-V
4111 Solanum melongena: 10.3109/14756369309040765
502766 Dioscorea althaeoides: 10.1016/J.BBAMEM.2012.12.010
64699 Dioscorea gracillima: 10.1016/J.BBAMEM.2012.12.010
4673 Dioscorea japonica: 10.1016/J.BBAMEM.2012.12.010
55575 Dioscorea polystachya: 10.1016/J.BBAMEM.2012.12.010
64475 Dioscorea tokoro: 10.1016/J.BBAMEM.2012.12.010
35875 Allium fistulosum: 10.1021/NP50080A003
261433 Maianthemum atropurpureum: 10.1016/J.STEROIDS.2006.04.005
49666 Paris polyphylla: 10.1016/S0031-9422(00)81066-3
580341 Dracaena cambodiana: 10.1016/J.FITOTE.2014.01.020
55186 Trillium grandiflorum: 10.1021/NP50055A013
746128 Aspergillus fumigatus: 10.1055/S-2004-827187
394303 Dioscorea deltoidea: 10.1042/BJ2190619
64700 Dioscorea nipponica:
4631 Costus: 10.1021/NP9702190
145674 Borassus: 10.1248/CPB.55.308
49674 Trillium: 10.1016/J.PHYTOCHEM.2008.08.004
64475 Dioscorea tokoro:
49657 Smilax china: 10.1016/J.FOODCHEM.2012.03.003
115514 Rhapis excelsa: 10.1248/CPB.32.4003
29657 Rhapis humilis: 10.1248/CPB.32.4003
329239 Hellenia lacera: 10.4268/CJCMM20111611
78534 Trigonella foenum-graecum: 10.1016/J.JPBA.2012.11.005
221254 Paris polyphylla var. chinensis:
100532 Dracaena draco:
374975 Dioscorea composita:
210369 Tribulus terrestris:
14027 Trachycarpus fortunei: 10.1248/CPB.32.295
54446 Chamaerops humilis: 10.1248/CPB.34.82
2654448 Dioscorea pseudojaponica:
158496 Triteleia hyacinthina: 10.1016/0031-9422(94)00790-Z
394307 Dioscorea spongiosa:
261420 Polygonatum kingianum: 10.1002/HLCA.200900308
4681 Allium ampeloprasum:
49657 Smilax china:
328752 Costus afer: 10.1021/NP9702190
145675 Borassus flabellifer: 10.1248/CPB.55.308
593754 Dracaena cochinchinensis: 10.1016/J.STEROIDS.2003.11.004
120020 Ypsilandra thibetica: 10.1016/J.STEROIDS.2009.07.001
50545 Trillium erectum:
1280193 Dracaena concinna: 10.1016/S0031-9422(97)00717-6
330167 Dioscorea villosa:
374971 Dioscorea futschauensis:
325984 Dioscorea zingiberensis:
1678672 Dioscorea saxatilis:
374974 Dioscorea sinoparviflora:
336258 Dioscorea panthaica:
930788 Dioscorea parviflora:
55634 Dioscorea communis:
240449 Urochloa decumbens: 10.1590/S0103-50532002000200002
64700 Dioscorea nipponica:
1280246 Sansevieria ehrenbergii: 10.1021/NP040203R
100504 Ophiopogon intermedius: 10.1016/0031-9422(88)80058-X
357959 Dioscorea collettii:
108051 Clintonia udensis: 10.1271/BBB.80003
1045158 Smilax menispermoidea:
261427 Polygonatum zanlanscianense:
143782 Dioscorea mexicana: 10.3109/13880209109082872
1632803 Melilotus tauricus: 10.1007/BF00630610
1045152 Smilax lebrunii: 10.1016/0031-9422(93)85048-V
4111 Solanum melongena: 10.3109/14756369309040765
502766 Dioscorea althaeoides: 10.1016/J.BBAMEM.2012.12.010
64699 Dioscorea gracillima: 10.1016/J.BBAMEM.2012.12.010
4673 Dioscorea japonica: 10.1016/J.BBAMEM.2012.12.010
55575 Dioscorea polystachya: 10.1016/J.BBAMEM.2012.12.010
64475 Dioscorea tokoro: 10.1016/J.BBAMEM.2012.12.010
35875 Allium fistulosum: 10.1021/NP50080A003
261433 Maianthemum atropurpureum: 10.1016/J.STEROIDS.2006.04.005
49666 Paris polyphylla: 10.1016/S0031-9422(00)81066-3
580341 Dracaena cambodiana: 10.1016/J.FITOTE.2014.01.020
55186 Trillium grandiflorum: 10.1021/NP50055A013
746128 Aspergillus fumigatus: 10.1055/S-2004-827187
394303 Dioscorea deltoidea: 10.1042/BJ2190619
49657 Smilax China: -
64700 Dioscorea nipponica Makino: -
33090 Plants: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Liwei Fan, Runfeng Ni, Haijin Wang, Le Zhang, Aidi Wang, Baoshan Liu. Dioscin alleviates aplastic anemia through regulatory T cells promotion. Hematology (Amsterdam, Netherlands). 2024 Dec; 29(1):2326389. doi: 10.1080/16078454.2024.2326389. [PMID: 38466633]
Jia Liu, Honglin Liu, Liangyan Deng, Tao Wang, Luyao Li, Yuanyuan Chen, Liping Qu, Wenjun Zou. Protective Role of Dioscin against Doxorubicin-Induced Chronic Cardiotoxicity: Insights from Nrf2-GPX4 Axis-Mediated Cardiac Ferroptosis. Biomolecules. 2024 Mar; 14(4):. doi: 10.3390/biom14040422. [PMID: 38672439]
Haoyang Gao, Ze Wang, Danlin Zhu, Linlin Zhao, Weihua Xiao. Dioscin: Therapeutic potential for diabetes and complications. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Jan; 170(?):116051. doi: 10.1016/j.biopha.2023.116051. [PMID: 38154275]
Yi Xiao, Fang Liu, Qinyi Wu, Xinting Zhu, Changyan Yu, Nian Jiang, Sanhua Li, Yun Liu. Dioscin activates endoplasmic reticulum UPR for defense against pathogen bacteria in Caenorhabditis elegans via IRE-1/XBP-1 pathway. The Journal of infectious diseases. 2023 Jul; ?(?):. doi: 10.1093/infdis/jiad294. [PMID: 37499184]
Yang Wang, Peng Liu, Guijie Ma, Chenguang Wu, Wenhui Zhu, Pengce Sun, Wenya Lu, Xinyu Yang, Yilun Zhang, Na Liu, Ping Li. Mechanism of dioscin ameliorating renal fibrosis through NF‑κB signaling pathway‑mediated inflammatory response. Molecular medicine reports. 2023 04; 27(4):. doi: 10.3892/mmr.2023.12980. [PMID: 36960871]
Xiao-Li Li, Xiu-Xiu Zhang, Run-Hui Ma, Zhi-Jing Ni, Kiran Thakur, Carlos L Cespedes-Acuña, Jian-Guo Zhang, Zhao-Jun Wei. Integrated miRNA and mRNA omics reveal dioscin suppresses migration and invasion via MEK/ERK and JNK signaling pathways in human endometrial carcinoma in vivo and in vitro. Journal of ethnopharmacology. 2023 Mar; 303(?):116027. doi: 10.1016/j.jep.2022.116027. [PMID: 36503030]
Donghua Yu, Jiaqi Fu, Yu Wang, Fang Lu, Pingping Chen, Shumin Liu. Integrative metabolomics and network pharmacology to study the preventative impact of dioscin treatment on hyperuricemia. Biomedical chromatography : BMC. 2023 Mar; 37(3):e5558. doi: 10.1002/bmc.5558. [PMID: 36468521]
Jing Xun, Siying Zhou, Zongjing Lv, Botao Wang, Hai Luo, Lanqiu Zhang, Lei Yang, Aimin Zhang, Xueliang Wu, Zhenyu Wang, Ximo Wang, Xiangyang Yu, Qi Zhang. Dioscin modulates macrophages polarization and MDSCs differentiation to inhibit tumorigenesis of colitis-associated colorectal cancer. International immunopharmacology. 2023 Feb; 117(?):109839. doi: 10.1016/j.intimp.2023.109839. [PMID: 36809720]
Chengfei Zhang, Qiue Zhang, Lingling Qin, Zhiyi Yan, Lili Wu, Tonghua Liu. Dioscin Ameliorates Experimental Autoimmune Thyroiditis via the mTOR and TLR4/NF-κB Signaling. Drug design, development and therapy. 2023; 17(?):2273-2285. doi: 10.2147/dddt.s410901. [PMID: 37551407]
Yu Kou, Qidi Sun, Rentao Zhu, Zhijie Lin, Zhuoqun Li, Hairong Xu, Xuan Feng, Yanqing Liu. Dioscin induces M1 macrophage polarization through Connexin-43 Channels in Tumor-associated-macrophages-mediated melanoma metastasis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Jan; 109(?):154559. doi: 10.1016/j.phymed.2022.154559. [PMID: 36610151]
Shofiul Azam, Yon-Suk Kim, Md Jakaria, Ye-Ji Yu, Jae-Yong Ahn, In-Su Kim, Dong-Kug Choi. Dioscorea nipponica Makino Rhizome Extract and Its Active Compound Dioscin Protect against Neuroinflammation and Scopolamine-Induced Memory Deficits. International journal of molecular sciences. 2022 Sep; 23(17):. doi: 10.3390/ijms23179923. [PMID: 36077321]
Zhe Zhang, Xuerong Zhao, Meng Gao, Lina Xu, Yan Qi, Jinhong Wang, Lianhong Yin. Dioscin alleviates myocardial infarction injury via regulating BMP4/NOX1-mediated oxidative stress and inflammation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Aug; 103(?):154222. doi: 10.1016/j.phymed.2022.154222. [PMID: 35675750]
Linshu Guan, Zhang Mao, Sen Yang, Guanlin Wu, Yurong Chen, Lianhong Yin, Yan Qi, Lan Han, Lina Xu. Dioscin alleviates Alzheimer's disease through regulating RAGE/NOX4 mediated oxidative stress and inflammation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Aug; 152(?):113248. doi: 10.1016/j.biopha.2022.113248. [PMID: 35691153]
Ruixia Bao, Wei Wang, Beibei Chen, Jujie Pan, Qian Chen, Mengyang Liu, Dan Wang, Yuzheng Wu, Haiyang Yu, Lifeng Han, Yi Zhang, Tao Wang. Dioscin Ameliorates Hyperuricemia-Induced Atherosclerosis by Modulating of Cholesterol Metabolism through FXR-Signaling Pathway. Nutrients. 2022 May; 14(9):. doi: 10.3390/nu14091983. [PMID: 35565954]
Yujie Zhong, Jiayu Liu, Dianjun Sun, Tianmin Guo, Yanpeng Yao, Xiaodong Xia, Chao Shi, Xiaoli Peng. Dioscin relieves diabetic nephropathy via suppressing oxidative stress and apoptosis, and improving mitochondrial quality and quantity control. Food & function. 2022 Mar; 13(6):3660-3673. doi: 10.1039/d1fo02733f. [PMID: 35262539]
Yanni Zhang, Le Liu, Na Li, Yihua Wang, Xuanfeng Yue. 3D scaffold fabricated with composite material for cell culture and its derived platform for safety evaluation of drugs. Toxicology. 2022 01; 466(?):153066. doi: 10.1016/j.tox.2021.153066. [PMID: 34919984]
Shinjini Bandopadhyay, Uttpal Anand, Vijaykumar Shivaji Gadekar, Niraj Kumar Jha, Piyush Kumar Gupta, Tapan Behl, Manoj Kumar, Radha, Mahipal S Shekhawat, Abhijit Dey. Dioscin: A review on pharmacological properties and therapeutic values. BioFactors (Oxford, England). 2022 Jan; 48(1):22-55. doi: 10.1002/biof.1815. [PMID: 34919768]
Le Zhang, Runfeng Ni, Jiani Li, Liwei Fan, Yanqi Song, Haijin Wang, Aidi Wang, Baoshan Liu. Dioscin Regulating Bone Marrow Apoptosis in Aplastic Anemia. Drug design, development and therapy. 2022; 16(?):3041-3053. doi: 10.2147/dddt.s370506. [PMID: 36105320]
Xiao Liu, Qian Zhou, Jia-He Zhang, Ke-Yong Wang, Takashi Saito, Takaomi C Saido, Xiaoying Wang, Xiumei Gao, Kagaku Azuma. Microglia-Based Sex-Biased Neuropathology in Early-Stage Alzheimer's Disease Model Mice and the Potential Pharmacologic Efficacy of Dioscin. Cells. 2021 11; 10(11):. doi: 10.3390/cells10113261. [PMID: 34831483]
Yun Zhang, Yuangen Li, Changda Lin, Jiequn Zhang, Hanyuan Gao, Jinhai Chen. Dioscin-loaded zein nanoparticles alleviate lipopolysaccharide-induced acute kidney injury via the microRNA-let 7i signalling pathways. IET nanobiotechnology. 2021 Jul; 15(5):465-472. doi: 10.1049/nbt2.12051. [PMID: 34694758]
Xiaofen Li, Sili Liu, Liping Qu, Yang Chen, Chuqiao Yuan, Anquan Qin, Jiyi Liang, Qianqian Huang, Miao Jiang, Wenjun Zou. Dioscin and diosgenin: Insights into their potential protective effects in cardiac diseases. Journal of ethnopharmacology. 2021 Jun; 274(?):114018. doi: 10.1016/j.jep.2021.114018. [PMID: 33716083]
Y Li, M Gao, L-H Yin, L-N Xu, Y Qi, Pengyuan Sun, J-Y Peng. Dioscin ameliorates methotrexate-induced liver and kidney damages via adjusting miRNA-145-5p-mediated oxidative stress. Free radical biology & medicine. 2021 06; 169(?):99-109. doi: 10.1016/j.freeradbiomed.2021.03.035. [PMID: 33836263]
Hui Tian, Xiyan Chen, Yafei Zhang, Ying Wang, Xucheng Fu, Weiting Gu, Yong Wen. Dioscin inhibits SCC15 cell proliferation via the RASSF1A/MST2/YAP axis. Molecular medicine reports. 2021 06; 23(6):. doi: 10.3892/mmr.2021.12053. [PMID: 33786612]
Cao Yongjun, Qiao Nan, Sun Yumeng, Jin Xiaowen, Wen Weibo. Dioscin alleviates hashimoto's thyroiditis by regulating the SUMOylation of IRF4 to promote CD4+CD25+Foxp3+ treg cell differentiation. Autoimmunity. 2021 02; 54(1):51-59. doi: 10.1080/08916934.2020.1855428. [PMID: 33274645]
Zhi Dai, Hui Liu, Bei Wang, Dong Yang, Yan-Yan Zhu, Huan Yan, Pei-Feng Zhu, Ya-Ping Liu, Hui-Cheng Chen, Yun-Li Zhao, Li-Xing Zhao, Xu-Dong Zhao, Hai-Yang Liu, Xiao-Dong Luo. Structures/cytotoxicity/selectivity relationship of natural steroidal saponins against GSCs and primary mechanism of tribulosaponin A. European journal of medicinal chemistry. 2021 Jan; 210(?):113068. doi: 10.1016/j.ejmech.2020.113068. [PMID: 33310292]
Yao Tan, Liming Wang, Jian Gao, Junhong Ma, Haiyang Yu, Yi Zhang, Tao Wang, Lifeng Han. Multiomics Integrative Analysis for Discovering the Potential Mechanism of Dioscin against Hyperuricemia Mice. Journal of proteome research. 2021 01; 20(1):645-660. doi: 10.1021/acs.jproteome.0c00584. [PMID: 33107303]
Yueyue Yang, Lianhong Yin, Manning Zhu, Shasha Song, Changjie Sun, Xu Han, Youwei Xu, Yanyan Zhao, Yan Qi, Lina Xu, J-Y Peng. Protective effects of dioscin on vascular remodeling in pulmonary arterial hypertension via adjusting GRB2/ERK/PI3K-AKT signal. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Jan; 133(?):111056. doi: 10.1016/j.biopha.2020.111056. [PMID: 33378960]
Xue-Min Yao, Feng-Ju Niu, Liang Kong, Fu-Yi Cai, Ming Jing, Min Fu, Jing-Jing Liu, Si-Yu He, Lu Zhang, Xin-Ze Liu, Rui-Jun Ju, Xue-Tao Li. GGP modified daunorubicin plus dioscin liposomes inhibit breast cancer by suppressing epithelial-mesenchymal transition. Drug development and industrial pharmacy. 2020 Jun; 46(6):916-930. doi: 10.1080/03639045.2020.1763397. [PMID: 32362146]
Shengyu Cai, Jiaxu Chen, Yousheng Li. Dioscin protects against diabetic nephropathy by inhibiting renal inflammation through TLR4/NF-κB pathway in mice. Immunobiology. 2020 05; 225(3):151941. doi: 10.1016/j.imbio.2020.151941. [PMID: 32359778]
L-N Xu, L-H Yin, Y Jin, Y Qi, X Han, Y-W Xu, K-X Liu, Y-Y Zhao, J-Y Peng. Effect and possible mechanisms of dioscin on ameliorating metabolic glycolipid metabolic disorder in type-2-diabetes. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Feb; 67(?):153139. doi: 10.1016/j.phymed.2019.153139. [PMID: 31881477]
Liang Kong, Fu-Yi Cai, Xue-Min Yao, Ming Jing, Min Fu, Jing-Jing Liu, Si-Yu He, Lu Zhang, Xin-Ze Liu, Rui-Jun Ju, Xue-Tao Li. RPV-modified epirubicin and dioscin co-delivery liposomes suppress non-small cell lung cancer growth by limiting nutrition supply. Cancer science. 2020 Feb; 111(2):621-636. doi: 10.1111/cas.14256. [PMID: 31777993]
Ying Li, Yong Li, Te Yang, Ming Wang. Dioscin attenuates oxLDL uptake and the inflammatory reaction of dendritic cells under high glucose conditions by blocking p38 MAPK. Molecular medicine reports. 2020 01; 21(1):304-310. doi: 10.3892/mmr.2019.10806. [PMID: 31746382]
Shan Peng, Ligai Bai, Xiaoqian Shi, Mingxue Li, Laisen Wang, Fanrong Sun, Haiyan Liu. A rapid method for on-line solid-phase extraction and determination of dioscin in human plasma using a homemade monolithic sorbent combined with high-performance liquid chromatography. Analytical and bioanalytical chemistry. 2020 Jan; 412(2):473-480. doi: 10.1007/s00216-019-02256-5. [PMID: 31792597]
Li An, Yongliang Yuan, Jingwei Ma, Hong Wang, Xiuying Piao, Junfeng Ma, Junfeng Zhang, Ling Zhou, Xujin Wu. NMR-based metabolomics approach to investigate the distribution characteristics of metabolites in Dioscorea opposita Thunb. cv. Tiegun. Food chemistry. 2019 Nov; 298(?):125063. doi: 10.1016/j.foodchem.2019.125063. [PMID: 31260979]
Qining Yang, Changyuan Wang, Yue Jin, Xiaodong Ma, Tianqi Xie, Jiaying Wang, Kexin Liu, Huijun Sun. Disocin prevents postmenopausal atherosclerosis in ovariectomized LDLR-/- mice through a PGC-1α/ERα pathway leading to promotion of autophagy and inhibition of oxidative stress, inflammation and apoptosis. Pharmacological research. 2019 10; 148(?):104414. doi: 10.1016/j.phrs.2019.104414. [PMID: 31449974]
Bonan Chen, Shikun Zhou, Yujuan Zhan, Junzi Ke, Kun Wang, Qiqi Liang, Yu Hou, Pingping Zhu, Weizhen Ao, Xianli Wei, Jianyong Xiao. Dioscin Inhibits the Invasion and Migration of Hepatocellular Carcinoma HepG2 Cells by Reversing TGF-β1-Induced Epithelial-Mesenchymal Transition. Molecules (Basel, Switzerland). 2019 Jun; 24(12):. doi: 10.3390/molecules24122222. [PMID: 31197076]
Jin Cheng, Chuang Sun, Jingyu Zhang, Qing Zou, Qimeng Hao, Yugang Xue. The Protective Effects of Preconditioning With Dioscin on Myocardial Ischemia/Reperfusion-Induced Ventricular Arrhythmias by Increasing Connexin 43 Expression in Rats. Journal of cardiovascular pharmacology and therapeutics. 2019 05; 24(3):262-268. doi: 10.1177/1074248418801567. [PMID: 30474396]
Zhang Mao, Xu Han, Dahong Chen, Youwei Xu, Lina Xu, Lianhong Yin, Huijun Sun, Yan Qi, Lingling Fang, Kexin Liu, Jinyong Peng. Potent effects of dioscin against hepatocellular carcinoma through regulating TP53-induced glycolysis and apoptosis regulator (TIGAR)-mediated apoptosis, autophagy, and DNA damage. British journal of pharmacology. 2019 04; 176(7):919-937. doi: 10.1111/bph.14594. [PMID: 30710454]
Yan Qi, Ruomiao Li, Lina Xu, Lianhong Yin, Youwei Xu, Xu Han, Jinyong Peng. Neuroprotective Effect of Dioscin on the Aging Brain. Molecules (Basel, Switzerland). 2019 Mar; 24(7):. doi: 10.3390/molecules24071247. [PMID: 30935017]
Haijuan Li, Lianzhi Yu, Changsheng Zhao. Dioscin attenuates high‑fat diet‑induced insulin resistance of adipose tissue through the IRS‑1/PI3K/Akt signaling pathway. Molecular medicine reports. 2019 02; 19(2):1230-1237. doi: 10.3892/mmr.2018.9700. [PMID: 30483735]
Yuanyuan Wang, Min Fu, Jingjing Liu, Yining Yang, Yibin Yu, Jinyu Li, Weisan Pan, Lei Fan, Guiru Li, Xuetao Li, Xiaobo Wang. Inhibition of tumor metastasis by targeted daunorubicin and dioscin codelivery liposomes modified with PFV for the treatment of non-small-cell lung cancer. International journal of nanomedicine. 2019; 14(?):4071-4090. doi: 10.2147/ijn.s194304. [PMID: 31239668]
Yong-Jun Cao, Ying Xu, Bei Liu, Xi Zheng, Jian Wu, Ying Zhang, Xiao-Si Li, Yan Qi, Yu-Meng Sun, Wei-Bo Wen, Lifei Hou, Chun-Ping Wan. Dioscin, a Steroidal Saponin Isolated from Dioscorea nipponica, Attenuates Collagen-Induced Arthritis by Inhibiting Th17 Cell Response. The American journal of Chinese medicine. 2019; 47(2):423-437. doi: 10.1142/s0192415x19500216. [PMID: 30827153]
Xuerong Zhao, Lianhong Yin, Lingling Fang, Lina Xu, Pengyuan Sun, Ming Xu, Kexin Liu, Jinyong Peng. Protective effects of dioscin against systemic inflammatory response syndromevia adjusting TLR2/MyD88/NF‑κb signal pathway. International immunopharmacology. 2018 Dec; 65(?):458-469. doi: 10.1016/j.intimp.2018.10.036. [PMID: 30390593]
Xufeng Tao, Lianhong Yin, Lina Xu, Jinyong Peng. Dioscin: A diverse acting natural compound with therapeutic potential in metabolic diseases, cancer, inflammation and infections. Pharmacological research. 2018 11; 137(?):259-269. doi: 10.1016/j.phrs.2018.09.022. [PMID: 30315966]
Bo Yang, Bin Xu, Hua Zhao, Ya-Bin Wang, Jian Zhang, Chuan-Wei Li, Qing Wu, Yu-Kang Cao, Yang Li, Feng Cao. Dioscin protects against coronary heart disease by reducing oxidative stress and inflammation via Sirt1/Nrf2 and p38 MAPK pathways. Molecular medicine reports. 2018 Jul; 18(1):973-980. doi: 10.3892/mmr.2018.9024. [PMID: 29845299]
Hong Yao, Xufeng Tao, Lina Xu, Yan Qi, Lianhong Yin, Xu Han, Youwei Xu, Lingli Zheng, Jinyong Peng. Dioscin alleviates non-alcoholic fatty liver disease through adjusting lipid metabolism via SIRT1/AMPK signaling pathway. Pharmacological research. 2018 05; 131(?):51-60. doi: 10.1016/j.phrs.2018.03.017. [PMID: 29574225]
Huiqing Zeng, Lijuan Yang, Xiaobin Zhang, Yan Chen, Jianghang Cai. Dioscin prevents LPS‑induced acute lung injury through inhibiting the TLR4/MyD88 signaling pathway via upregulation of HSP70. Molecular medicine reports. 2018 05; 17(5):6752-6758. doi: 10.3892/mmr.2018.8667. [PMID: 29512786]
Ashish Kumar, Antim K Maurya, Gopi Chand, Vijai K Agnihotri. Comparative metabolic profiling of Costus speciosus leaves and rhizomes using NMR, GC-MS and UPLC/ESI-MS/MS. Natural product research. 2018 Apr; 32(7):826-833. doi: 10.1080/14786419.2017.1365069. [PMID: 28814124]
Yi Zhang, Lijun Jin, Jinchang Liu, Wei Wang, Haiyang Yu, Jian Li, Qian Chen, Tao Wang. Effect and mechanism of dioscin from Dioscorea spongiosa on uric acid excretion in animal model of hyperuricemia. Journal of ethnopharmacology. 2018 Mar; 214(?):29-36. doi: 10.1016/j.jep.2017.12.004. [PMID: 29233733]
Yujie Qiao, Lina Xu, Xufeng Tao, Lianhong Yin, Yan Qi, Youwei Xu, Xu Han, Zeyao Tang, Xiaodong Ma, Kexin Liu, Jinyong Peng. Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation. Toxicology letters. 2018 Mar; 284(?):37-45. doi: 10.1016/j.toxlet.2017.11.031. [PMID: 29197622]
Shu Li, Binbin Cheng, Lixin Hou, Lanwei Huang, Yongkang Cui, Duo Xu, Xiaoping Shen, Shuang Li. Dioscin inhibits colon cancer cells' growth by reactive oxygen species-mediated mitochondrial dysfunction and p38 and JNK pathways. Anti-cancer drugs. 2018 03; 29(3):234-242. doi: 10.1097/cad.0000000000000590. [PMID: 29389802]
Jia Li, Qin Liang, Changfu Li, Mengdi Liu, Yansheng Zhang. Comparative Transcriptome Analysis Identifies Putative Genes Involved in Dioscin Biosynthesis in Dioscorea zingiberensis. Molecules (Basel, Switzerland). 2018 Feb; 23(2):. doi: 10.3390/molecules23020454. [PMID: 29463020]
Longfei Yang, Xin Liu, Lili Zhong, Yujie Sui, Guihua Quan, Ying Huang, Fang Wang, Tonghui Ma. Dioscin Inhibits Virulence Factors of Candida albicans. BioMed research international. 2018; 2018(?):4651726. doi: 10.1155/2018/4651726. [PMID: 30598996]
Ping Wang, Li-Ya He, Guo-Dong Shen, Rui-Lin Li, Jun-Li Yang. Inhibitory effects of Dioscin on atherosclerosis and foam cell formation in hyperlipidemia rats. Inflammopharmacology. 2017 Dec; 25(6):633-642. doi: 10.1007/s10787-017-0341-4. [PMID: 28365854]
Ying Jiao, Hong-Ye Ju, Kun-Xia Hu, Zhi-Shu Tang, Xiao Song. [Preparation and evaluation of dioscin nanostructured lipid carriers]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2017 Oct; 42(19):3747-3754. doi: 10.19540/j.cnki.cjcmm.20170808.001. [PMID: 29235290]
Yimeng Zhang, Xufeng Tao, Lianhong Yin, Lina Xu, Youwei Xu, Yan Qi, Xu Han, Shasha Song, Yanyan Zhao, Yuan Lin, Kexin Liu, Jinyong Peng. Protective effects of dioscin against cisplatin-induced nephrotoxicity via the microRNA-34a/sirtuin 1 signalling pathway. British journal of pharmacology. 2017 08; 174(15):2512-2527. doi: 10.1111/bph.13862. [PMID: 28514495]
Xuejiao Li, Chengcheng Zhao, Songsong Jing, Jiachen Sun, Xia Li, Shuli Man, Ying Wang, Wenyuan Gao. Novel phenanthrene and isocoumarin from the rhizomes of Dioscorea nipponica Makino subsp. rosthornii (Prain et Burkill) C. T. Ting (Dioscoreaceae). Bioorganic & medicinal chemistry letters. 2017 08; 27(15):3595-3601. doi: 10.1016/j.bmcl.2017.03.095. [PMID: 28606759]
Jing Zhao, Youwei Xu, Changyuan Wang, Yanfang Ding, Manyu Chen, Yifei Wang, Jinyong Peng, Lei Li, Li Lv. Soluplus/TPGS mixed micelles for dioscin delivery in cancer therapy. Drug development and industrial pharmacy. 2017 Jul; 43(7):1197-1204. doi: 10.1080/03639045.2017.1304956. [PMID: 28300426]
Kyo Bin Kang, Jayoung Ryu, Youngwoong Cho, Sang-Zin Choi, Miwon Son, Sang Hyun Sung. Combined Application of UHPLC-QTOF/MS, HPLC-ELSD and 1 H-NMR Spectroscopy for Quality Assessment of DA-9801, A Standardised Dioscorea Extract. Phytochemical analysis : PCA. 2017 May; 28(3):185-194. doi: 10.1002/pca.2659. [PMID: 27910174]
Yimeng Zhang, Youwei Xu, Yan Qi, Lina Xu, Shasha Song, Lianhong Yin, Xufeng Tao, Yuhong Zhen, Xu Han, Xiaodong Ma, Kexin Liu, Jinyong Peng. Protective effects of dioscin against doxorubicin-induced nephrotoxicity via adjusting FXR-mediated oxidative stress and inflammation. Toxicology. 2017 03; 378(?):53-64. doi: 10.1016/j.tox.2017.01.007. [PMID: 28082111]
Fan Yang, Yuqiong Liang, Li Xu, Leilei Ji, Nan Yao, Ruonan Liu, Le Shi, Tao Liang. Exploration in the cascade working mechanisms of liver injury induced by total saponins extracted from Rhizoma Dioscorea bulbifera. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2016 Oct; 83(?):1048-1056. doi: 10.1016/j.biopha.2016.08.017. [PMID: 27544548]
Ting Ma, Rui-Ping Wang, Xi Zou. Dioscin inhibits gastric tumor growth through regulating the expression level of lncRNA HOTAIR. BMC complementary and alternative medicine. 2016 Sep; 16(1):383. doi: 10.1186/s12906-016-1360-1. [PMID: 27751178]
Meng Qi, Lianhong Yin, Lina Xu, Xufeng Tao, Yan Qi, Xu Han, Changyuan Wang, Youwei Xu, Huijun Sun, Kexin Liu, Jinyong Peng. Dioscin alleviates lipopolysaccharide-induced inflammatory kidney injury via the microRNA let-7i/TLR4/MyD88 signaling pathway. Pharmacological research. 2016 09; 111(?):509-522. doi: 10.1016/j.phrs.2016.07.016. [PMID: 27431331]
Pei Chen, Hong-Yu Jin, Lei Sun, Shuang-Cheng Ma. Multi-component determination and chemometric analysis of Paris polyphylla by ultra high performance liquid chromatography with photodiode array detection. Journal of separation science. 2016 Sep; 39(18):3550-7. doi: 10.1002/jssc.201600259. [PMID: 27461897]
Pranapda Aumsuwan, Shabana I Khan, Ikhlas A Khan, Zulfiqar Ali, Bharathi Avula, Larry A Walker, Zia Shariat-Madar, William G Helferich, Benita S Katzenellenbogen, Asok K Dasmahapatra. The anticancer potential of steroidal saponin, dioscin, isolated from wild yam (Dioscorea villosa) root extract in invasive human breast cancer cell line MDA-MB-231 in vitro. Archives of biochemistry and biophysics. 2016 Feb; 591(?):98-110. doi: 10.1016/j.abb.2015.12.001. [PMID: 26682631]
Meiyu Wang, Huixin Qi, Jiajun Li, Yunting Xu, Hongjian Zhang. Transmembrane transport of steviol glucuronide and its potential interaction with selected drugs and natural compounds. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2015 Dec; 86(?):217-24. doi: 10.1016/j.fct.2015.10.011. [PMID: 26525112]
Lin-Sen Qing, Ying Xue, Li-Sheng Ding, Yi-Ming Liu, Jian Liang, Xun Liao. A Rapid Study of Botanical Drug-Drug Interaction with Protein by Re-ligand Fishing using Human Serum Albumin-Functionalized Magnetic Nanoparticles. Natural product communications. 2015 Dec; 10(12):2161-3. doi: NULL. [PMID: 26882690]
Meng Qi, Lingli Zheng, Yan Qi, Xu Han, Youwei Xu, Lina Xu, Lianhong Yin, Changyuan Wang, Yanyan Zhao, Huijun Sun, Kexin Liu, Jinyong Peng. Dioscin attenuates renal ischemia/reperfusion injury by inhibiting the TLR4/MyD88 signaling pathway via up-regulation of HSP70. Pharmacological research. 2015 Oct; 100(?):341-52. doi: 10.1016/j.phrs.2015.08.025. [PMID: 26348276]
Atsuyoshi Nishina, Kodai Ebina, Motohiko Ukiya, Makoto Fukatsu, Mamoru Koketsu, Masayuki Ninomiya, Daisuke Sato, Hirokazu Kimura. Dioscin Derived from Solanum melongena L. "Usukawamarunasu" Attenuates α-MSH-Induced Melanogenesis in B16 Murine Melanoma Cells via Downregulation of Phospho-CREB and MITF. Journal of food science. 2015 Oct; 80(10):H2354-9. doi: 10.1111/1750-3841.13068. [PMID: 26352003]
He Zhu, Jin-Di Xu, Qian Mao, Hong Shen, Ming Kong, Jian-Ping Chen, Song-Lin Li. Metabolic profiles of dioscin in rats revealed by ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry. Biomedical chromatography : BMC. 2015 Sep; 29(9):1415-21. doi: 10.1002/bmc.3439. [PMID: 25678372]
Hyun Jae Lee, Jin Sung Park, Yong Pill Yoon, Ye Jin Shin, Sang Kook Lee, Yeong Shik Kim, Jang-Hee Hong, Kun Ho Son, Choong Jae Lee. Dioscin and methylprotodioscin isolated from the root of Asparagus cochinchinensis suppressed the gene expression and production of airway MUC5AC mucin induced by phorbol ester and growth factor. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2015 May; 22(5):568-72. doi: 10.1016/j.phymed.2015.03.009. [PMID: 25981923]
Yi-Na Tang, Yu-Xin Pang, Xi-Cheng He, Ya-Zhou Zhang, Jian-Ye Zhang, Zhong-Zhen Zhao, Tao Yi, Hu-Biao Chen. UPLC-QTOF-MS identification of metabolites in rat biosamples after oral administration of Dioscorea saponins: a comparative study. Journal of ethnopharmacology. 2015 May; 165(?):127-40. doi: 10.1016/j.jep.2015.02.017. [PMID: 25698242]
Lianhong Yin, Lingli Zheng, Lina Xu, Deshi Dong, Xu Han, Yan Qi, Yanyan Zhao, Youwei Xu, Jinyong Peng. In-silico prediction of drug targets, biological activities, signal pathways and regulating networks of dioscin based on bioinformatics. BMC complementary and alternative medicine. 2015 Mar; 15(?):41. doi: 10.1186/s12906-015-0579-6. [PMID: 25879470]
Min Liu, Lina Xu, Lianhong Yin, Yan Qi, Youwei Xu, Xu Han, Yanyan Zhao, Huijun Sun, Jihong Yao, Yuan Lin, Kexin Liu, Jinyong Peng. Potent effects of dioscin against obesity in mice. Scientific reports. 2015 Jan; 5(?):7973. doi: 10.1038/srep07973. [PMID: 25609476]
Keiko Taketani, Shohei Hoshino, Taku Uemura, Tsuyoshi Goto, Nobuyuki Takahashi, Nobuaki Tsuge, Teruo Kawada. An Efficient Purification Method for Quantitative Determinations of Protodioscin, Dioscin and Diosgenin in Plasma of Fenugreek-Fed Mice. Journal of nutritional science and vitaminology. 2015; 61(6):465-70. doi: 10.3177/jnsv.61.465. [PMID: 26875488]
Li-Na Xu, Yong-Li Wei, Jin-Yong Peng. [Advances in study of dioscin--a natural product]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2015 Jan; 40(1):36-41. doi: . [PMID: 25993784]
Yong-Kook Kwon, Eun Yee Jie, Alieu Sartie, Dong Jin Kim, Jang Ryol Liu, Byung Whan Min, Suk Weon Kim. Rapid metabolic discrimination and prediction of dioscin content from African yam tubers using Fourier transform-infrared spectroscopy combined with multivariate analysis. Food chemistry. 2015 Jan; 166(?):389-396. doi: 10.1016/j.foodchem.2014.06.035. [PMID: 25053072]
Barun Poudel, Seong-Won Lim, Hyeon-Hui Ki, Sarmila Nepali, Young-Mi Lee, Dae-Ki Kim. Dioscin inhibits adipogenesis through the AMPK/MAPK pathway in 3T3-L1 cells and modulates fat accumulation in obese mice. International journal of molecular medicine. 2014 Nov; 34(5):1401-8. doi: 10.3892/ijmm.2014.1921. [PMID: 25189808]
Junxia Su, Yuhui Wei, Minglong Liu, Tianxi Liu, Jianhua Li, Yuanchun Ji, Jianping Liang. Anti-hyperuricemic and nephroprotective effects of Rhizoma Dioscoreae septemlobae extracts and its main component dioscin via regulation of mOAT1, mURAT1 and mOCT2 in hypertensive mice. Archives of pharmacal research. 2014 Oct; 37(10):1336-44. doi: 10.1007/s12272-014-0413-6. [PMID: 24866061]
Fang Lu, Lei Liu, Dong-hua Yu, Xu-zhao Li, Qi Zhou, Shu-min Liu. Therapeutic effect of Rhizoma Dioscoreae Nipponicae on gouty arthritis based on the SDF-1/CXCR 4 and p38 MAPK pathway: an in vivo and in vitro study. Phytotherapy research : PTR. 2014 Feb; 28(2):280-8. doi: 10.1002/ptr.4997. [PMID: 23620384]
Benwei Wang, Songgang Ji, Hai Zhang, Liang Zhao, Lei Lv, Yueyue Li, Guichen Zhou, Guoqing Zhang. Liquid chromatography tandem mass spectrometry in study of the pharmacokinetics of six steroidal saponins in rats. Steroids. 2013 Dec; 78(12-13):1164-70. doi: 10.1016/j.steroids.2013.08.009. [PMID: 24012730]
Ming-Ju Hsieh, Te-Lung Tsai, Yih-Shou Hsieh, Chau-Jong Wang, Hui-Ling Chiou. Dioscin-induced autophagy mitigates cell apoptosis through modulation of PI3K/Akt and ERK and JNK signaling pathways in human lung cancer cell lines. Archives of toxicology. 2013 Nov; 87(11):1927-1937. doi: 10.1007/s00204-013-1047-z. [PMID: 23552851]
Vamshi K Manda, Bharathi Avula, Zulfiqar Ali, Yan-Hong Wong, Troy J Smillie, Ikhlas A Khan, Shabana I Khan. Characterization of in vitro ADME properties of diosgenin and dioscin from Dioscorea villosa. Planta medica. 2013 Oct; 79(15):1421-8. doi: 10.1055/s-0033-1350699. [PMID: 23970424]
Linlin Lv, Lingli Zheng, Deshi Dong, Lina Xu, Lianhong Yin, Youwei Xu, Yan Qi, Xu Han, Jinyong Peng. Dioscin, a natural steroid saponin, induces apoptosis and DNA damage through reactive oxygen species: a potential new drug for treatment of glioblastoma multiforme. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2013 Sep; 59(?):657-69. doi: 10.1016/j.fct.2013.07.012. [PMID: 23871826]
Ya-Chun Guo, Ya-Xian Gao, Hong-Ru Song. [Effects of dioscornin tablet containing serum on NF-kappaB p65, STAT3, and VEGF mRNA expressions in rats' synovial cell strain RSC-364 induced by IL-17 and TNF-alpha]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2013 Jun; 33(6):814-8. doi: NULL. [PMID: 23980365]
Aijie Zhang, Changyuan Wang, Qi Liu, Qiang Meng, Jinyong Peng, Huijun Sun, Xiaochi Ma, Xiaokui Huo, Kexin Liu. Involvement of organic anion-transporting polypeptides in the hepatic uptake of dioscin in rats and humans. Drug metabolism and disposition: the biological fate of chemicals. 2013 May; 41(5):994-1003. doi: 10.1124/dmd.112.049452. [PMID: 23396419]
Chun-Hsu Pan, Chia-Hua Tsai, Fon-Chang Liu, Ming-Jen Fan, Ming-Jyh Sheu, Wen-Tsong Hsieh, Chieh-Hsi Wu. Influence of different particle processing on hypocholesterolemic and antiatherogenic activities of yam (Dioscorea pseudojaponica) in cholesterol-fed rabbit model. Journal of the science of food and agriculture. 2013 Apr; 93(6):1278-83. doi: 10.1002/jsfa.5882. [PMID: 23400896]
Jaeyong Cho, Hyemin Choi, Juneyoung Lee, Mi-Sun Kim, Ho-Yong Sohn, Dong Gun Lee. The antifungal activity and membrane-disruptive action of dioscin extracted from Dioscorea nipponica. Biochimica et biophysica acta. 2013 Mar; 1828(3):1153-8. doi: 10.1016/j.bbamem.2012.12.010. [PMID: 23262192]
Chaohong Liu, Yun Wang, Chunchen Wu, Rongjuan Pei, Jianhua Song, Shiyun Chen, Xinwen Chen. Dioscin's antiviral effect in vitro. Virus research. 2013 Mar; 172(1-2):9-14. doi: 10.1016/j.virusres.2012.12.001. [PMID: 23238077]
Yong-Sik Kim, Eun-Ae Kim, Kyu-Gun Park, Sung-Jun Lee, Mi-Sun Kim, Ho-Yong Sohn, Tae-Jin Lee. Dioscin sensitizes cells to TRAIL-induced apoptosis through downregulation of c-FLIP and Bcl-2. Oncology reports. 2012 Nov; 28(5):1910-6. doi: 10.3892/or.2012.1962. [PMID: 22895655]
Chun Liang, Ju-Hwan Lim, Seung-Hyung Kim, Dong-Seon Kim. Dioscin: a synergistic tyrosinase inhibitor from the roots of Smilax china. Food chemistry. 2012 Sep; 134(2):1146-8. doi: 10.1016/j.foodchem.2012.03.003. [PMID: 23107741]
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