Liquiritigenin (BioDeep_00000270165)

Main id: BioDeep_00000000383

Secondary id: BioDeep_00000860867

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


(S) -2,3-Dihydro-7-hydroxy-2- (4-hydroxyphenyl) -4H-1-benzopyran-4-one

化学式: C15H12O4 (256.0736)
中文名称: 甘草素
谱图信息: 最多检出来源 Ferula hexiensis(otcml) 3.77%

分子结构信息

SMILES: C1C(OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)O
InChI: InChI=1S/C15H12O4/c16-10-3-1-9(2-4-10)14-8-13(18)12-6-5-11(17)7-15(12)19-14/h1-7,14,16-17H,8H2/t14-/m0/s1

描述信息

Origin: Plant; Formula(Parent): C15H12O4; Bottle Name:Liquiritigenin; PRIME Parent Name:4,7-Dihydroxyflavanone; PRIME in-house No.:T0084, Pyrans
Bottle Name:Liquiritigenin; Origin: Plant; Formula(Parent): C15H12O4; PRIME Parent Name:4,7-Dihydroxyflavanone; PRIME in-house No.:T0084, Pyrans
Liquiritigenin, a flavanone isolated from Glycyrrhiza uralensis, is a highly selective estrogen receptor β (ERβ) agonist with an EC50 of 36.5 nM for activation of the ERE tk-Luc.
Liquiritigenin, a flavanone isolated from Glycyrrhiza uralensis, is a highly selective estrogen receptor β (ERβ) agonist with an EC50 of 36.5 nM for activation of the ERE tk-Luc.

同义名列表

5 个代谢物同义名

Liquiritigenin; (S) -2,3-Dihydro-7-hydroxy-2- (4-hydroxyphenyl) -4H-1-benzopyran-4-one; 4,7-Dihydroxyflavanone; 4',7-Dihydroxyflavanone; Liquiritigenin



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

74 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 AKT1, BCL2, BDNF, CASP3, ESR1, KEAP1, MAPK14, MTOR, NFE2L2, PIK3CA, PTGS2, RELA
Peripheral membrane protein 5 ACHE, CYP1B1, ESR1, MTOR, PTGS2
Endoplasmic reticulum membrane 4 BCL2, CYP1B1, MTOR, PTGS2
Nucleus 12 ACHE, AKT1, BCL2, CASP3, ESR1, ESR2, KEAP1, MAPK14, MTOR, NFE2L2, PARP1, RELA
cytosol 11 AKT1, BCL2, CASP3, ESR1, KEAP1, MAPK14, MTOR, NFE2L2, PARP1, PIK3CA, RELA
dendrite 2 BDNF, MTOR
nuclear body 1 PARP1
phagocytic vesicle 1 MTOR
centrosome 1 NFE2L2
nucleoplasm 10 AKT1, CASP3, ESR1, ESR2, KEAP1, MAPK14, MTOR, NFE2L2, PARP1, RELA
RNA polymerase II transcription regulator complex 1 NFE2L2
Cell membrane 4 ACHE, AKT1, ESR1, TNF
Cytoplasmic side 2 ESR1, MTOR
lamellipodium 2 AKT1, PIK3CA
Golgi apparatus membrane 1 MTOR
Synapse 1 ACHE
cell cortex 1 AKT1
cell surface 2 ACHE, TNF
glutamatergic synapse 4 AKT1, CASP3, MAPK14, RELA
Golgi apparatus 3 ACHE, ESR1, NFE2L2
Golgi membrane 1 MTOR
lysosomal membrane 1 MTOR
neuromuscular junction 1 ACHE
neuronal cell body 2 CASP3, TNF
postsynapse 1 AKT1
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 2 NFE2L2, PARP1
Lysosome 1 MTOR
plasma membrane 7 ACHE, AKT1, BCHE, ESR1, NFE2L2, PIK3CA, TNF
Membrane 8 ACHE, AKT1, BCL2, BDNF, CYP1B1, ESR1, MTOR, PARP1
axon 1 BDNF
caveola 1 PTGS2
extracellular exosome 1 MMP9
Lysosome membrane 1 MTOR
endoplasmic reticulum 3 BCL2, KEAP1, PTGS2
extracellular space 6 ACHE, BCHE, BDNF, IL6, MMP9, TNF
perinuclear region of cytoplasm 3 ACHE, BDNF, PIK3CA
intercalated disc 1 PIK3CA
mitochondrion 5 BCL2, CYP1B1, ESR2, MAPK14, PARP1
protein-containing complex 5 AKT1, BCL2, ESR1, PARP1, PTGS2
intracellular membrane-bounded organelle 2 CYP1B1, ESR2
Microsome membrane 3 CYP1B1, MTOR, PTGS2
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 4 ACHE, BCHE, BDNF, IL6
extracellular region 7 ACHE, BCHE, BDNF, IL6, MAPK14, MMP9, TNF
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, MTOR
Extracellular side 1 ACHE
transcription regulator complex 3 ESR1, PARP1, RELA
centriolar satellite 1 KEAP1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 TNF
Secreted, extracellular space, extracellular matrix 1 MMP9
microtubule cytoskeleton 1 AKT1
nucleolus 1 PARP1
midbody 1 KEAP1
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Membrane raft 1 TNF
pore complex 1 BCL2
spindle 1 AKT1
basement membrane 1 ACHE
Nucleus, PML body 1 MTOR
PML body 1 MTOR
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 MMP9
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 5 ESR1, ESR2, NFE2L2, PARP1, RELA
mediator complex 1 NFE2L2
phagocytic cup 1 TNF
Chromosome 1 PARP1
Nucleus, nucleolus 1 PARP1
spindle pole 1 MAPK14
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
actin filament 1 KEAP1
blood microparticle 1 BCHE
Lipid-anchor, GPI-anchor 1 ACHE
site of double-strand break 1 PARP1
Cul3-RING ubiquitin ligase complex 1 KEAP1
nuclear envelope 2 MTOR, PARP1
Endomembrane system 1 MTOR
euchromatin 1 ESR1
side of membrane 1 ACHE
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 2 MAPK14, MMP9
secretory granule lumen 1 MAPK14
endoplasmic reticulum lumen 4 BCHE, BDNF, IL6, PTGS2
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
tertiary granule lumen 1 MMP9
nuclear envelope lumen 1 BCHE
[Isoform 1]: Nucleus 1 ESR1
synaptic cleft 1 ACHE
protein-DNA complex 2 NFE2L2, PARP1
death-inducing signaling complex 1 CASP3
Cytoplasmic vesicle, phagosome 1 MTOR
site of DNA damage 1 PARP1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
inclusion body 1 KEAP1
interleukin-6 receptor complex 1 IL6
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
NF-kappaB p50/p65 complex 1 RELA
[Isoform H]: Cell membrane 1 ACHE
NF-kappaB complex 1 RELA
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Peijun Sun, Huixian Chen, Xiaoyu Fan, Jiayi Wang, Lujie Lu, Guangchao Yang, Jining Liu, Weifeng Yao, Feng Ding, Jie Ding, Jianmei Liu, Tulin Lu, Lihong Chen. Exploring the effective components of honey-processed licorice (Glycyrrhiza uralensis Fisch.) in attenuating Doxorubicin-induced myocardial cytotoxicity by combining network pharmacology and in vitro experiments. Journal of ethnopharmacology. 2024 Jul; 329(?):118178. doi: 10.1016/j.jep.2024.118178. [PMID: 38604511]
  • Lei Bao, Pei Hao, Meiju Jiang, Weijiang Chu. Liquiritigenin regulates insulin sensitivity and ameliorates inflammatory responses in the nonalcoholic fatty liver by activation PI3K/AKT pathway. Chemical biology & drug design. 2023 Jul; ?(?):. doi: 10.1111/cbdd.14292. [PMID: 37455324]
  • Atieh Hajirahimkhan, Caitlin Howell, Elizabeth T Bartom, Huali Dong, Daniel D Lantvit, Xiaoling Xuei, Shao-Nong Chen, Guido F Pauli, Judy L Bolton, Susan E Clare, Seema A Khan, Birgit M Dietz. Breast cancer prevention with liquiritigenin from licorice through the inhibition of aromatase and protein biosynthesis in high-risk women's breast tissue. Scientific reports. 2023 05; 13(1):8734. doi: 10.1038/s41598-023-34762-z. [PMID: 37253812]
  • Vineet Babu, Deepak Singh Kapkoti, Monika Binwal, Rajendra S Bhakuni, Karuna Shanker, Manju Singh, Sudeep Tandon, Madhav N Mugale, Narendra Kumar, Dnyaneshwar U Bawankule. Liquiritigenin, isoliquiritigenin rich extract of glycyrrhiza glabra roots attenuates inflammation in macrophages and collagen-induced arthritis in rats. Inflammopharmacology. 2023 Mar; ?(?):. doi: 10.1007/s10787-023-01152-w. [PMID: 36947299]
  • Qi Lu, Lin-Feng Zou, Yuan-Zhen Gao, Ting Ye, Meng-Jiao Li, Yu-Kun Zhang, Bing Liang, Wenshe Sun, Dong-Ming Xing. Liquiritigenin reverses skin aging by inhibiting UV-induced mitochondrial uncoupling and excessive energy consumption. Journal of cosmetic dermatology. 2023 Mar; 22(3):1017-1030. doi: 10.1111/jocd.15506. [PMID: 36575875]
  • Muqing Zhang, Jiaying Qi, Qianqian He, Donglai Ma, Jing Li, Xi Chu, Saijie Zuo, Yixin Zhang, Li Li, Li Chu. Liquiritigenin protects against myocardial ischemic by inhibiting oxidative stress, apoptosis, and L-type Ca2+ channels. Phytotherapy research : PTR. 2022 Sep; 36(9):3619-3631. doi: 10.1002/ptr.7528. [PMID: 35747908]
  • Meng Zhou, Yanpeng Dai, Yong Ma, Yi Yan, Min Hua, Qi Gao, Xue Geng, Qian Zhou. Protective Effects of Liquiritigenin against Cisplatin-Induced Nephrotoxicity via NRF2/SIRT3-Mediated Improvement of Mitochondrial Function. Molecules (Basel, Switzerland). 2022 Jun; 27(12):. doi: 10.3390/molecules27123823. [PMID: 35744945]
  • Hong Qin, Ziyu Song, Chunyu Zhao, Jinxin Yang, Fan Xia, Lewen Wang, Anwar Ali, Wenya Zheng. Liquiritigenin Inhibits Lipid Accumulation in 3T3-L1 Cells via mTOR-Mediated Regulation of the Autophagy Mechanism. Nutrients. 2022 Mar; 14(6):. doi: 10.3390/nu14061287. [PMID: 35334944]
  • Zhibing Xu, Zongde Hu, Hanchen Xu, Lifen Zhang, Liang Li, Yi Wang, Yuanqing Zhu, Limeng Yang, Dan Hu. Liquiritigenin alleviates doxorubicin-induced chronic heart failure via promoting ARHGAP18 and suppressing RhoA/ROCK1 pathway. Experimental cell research. 2022 02; 411(2):113008. doi: 10.1016/j.yexcr.2022.113008. [PMID: 34990617]
  • Zhanwei Zhang, Jie Lin, Jinhui Hu, Lifang Liu. Liquiritigenin Blocks Breast Cancer Progression by Inhibiting Connective Tissue Growth Factor Expression via Up-Regulating miR-383-5p. International journal of toxicology. 2022 Jan; 41(1):5-15. doi: 10.1177/10915818211059470. [PMID: 35045746]
  • Yingchen Ji, Weiwei Hu, Yan Jin, Huiming Yu, Jin Fang. Liquiritigenin exerts the anti-cancer role in oral cancer via inducing autophagy-related apoptosis through PI3K/AKT/mTOR pathway inhibition in vitro and in vivo. Bioengineered. 2021 12; 12(1):6070-6082. doi: 10.1080/21655979.2021.1971501. [PMID: 34488535]
  • Muqing Zhang, Yucong Xue, Bin Zheng, Li Li, Xi Chu, Yang Zhao, Yongchao Wu, Jianping Zhang, Xue Han, Zhonglin Wu, Li Chu. Liquiritigenin protects against arsenic trioxide-induced liver injury by inhibiting oxidative stress and enhancing mTOR-mediated autophagy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Nov; 143(?):112167. doi: 10.1016/j.biopha.2021.112167. [PMID: 34560535]
  • Li Li, Hui Fang, Yong-Hong Yu, Shan-Xin Liu, Zhi-Qiang Yang. Liquiritigenin attenuates isoprenaline‑induced myocardial fibrosis in mice through the TGF‑β1/Smad2 and AKT/ERK signaling pathways. Molecular medicine reports. 2021 Oct; 24(4):. doi: 10.3892/mmr.2021.12326. [PMID: 34328199]
  • Yexiang Du, Min Luo, Yehong Du, Mingliang Xu, Qiuhui Yao, Kejian Wang, Guiqiong He. Liquiritigenin Decreases Aβ Levels and Ameliorates Cognitive Decline by Regulating Microglia M1/M2 Transformation in AD Mice. Neurotoxicity research. 2021 Apr; 39(2):349-358. doi: 10.1007/s12640-020-00284-z. [PMID: 32990912]
  • Eun Ju Lee, Sibhghatulla Shaikh, Khurshid Ahmad, Syed Sayeed Ahmad, Jeong Ho Lim, Soyoung Park, Hye Jin Yang, Won-Kyung Cho, Sang-Joon Park, Yong-Ho Lee, So-Young Park, Jin-Yeul Ma, Inho Choi. Isolation and Characterization of Compounds from Glycyrrhiza uralensis as Therapeutic Agents for the Muscle Disorders. International journal of molecular sciences. 2021 Jan; 22(2):. doi: 10.3390/ijms22020876. [PMID: 33467209]
  • Mingming Qin, Aili Guo, Feng Li, Fuxiang Zhang, Meirong Bi, Yamin Zhang, Weiwei Zhu. Liquiritigenin enhances cyclic adenosine monophosphate production to mitigate inflammation in dendritic cells. International journal of immunopathology and pharmacology. 2021 Jan; 35(?):20587384211038098. doi: 10.1177/20587384211038098. [PMID: 34939873]
  • Chang-Can Shi, Kun-Ming Qin, Ke Xu, An Chen, Ting Cai, Bao-Chang Cai. Development of liquiritigenin-phospholipid complex with the enhanced oral bioavailability. Chinese journal of natural medicines. 2020 Dec; 18(12):916-921. doi: 10.1016/s1875-5364(20)60035-8. [PMID: 33357722]
  • Tianyang Wang, Song Lin, Hua Li, Ran Liu, Zihan Liu, Huarong Xu, Qing Li, Kaishun Bi. A stepwise integrated multi-system to screen quality markers of Chinese classic prescription Qingzao Jiufei decoction on the treatment of acute lung injury by combining 'network pharmacology-metabolomics-PK/PD modeling'. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Nov; 78(?):153313. doi: 10.1016/j.phymed.2020.153313. [PMID: 32866904]
  • Su-Jin Ahn, Hyung Joo Kim, Ayoung Lee, Seung-Sik Min, Sangwhan In, Eunmi Kim. Determination of 12 herbal compounds for estimating the presence of Angelica Gigas Root, Cornus Fruit, Licorice Root, Pueraria Root, and Schisandra Fruit in foods by LC-MS/MS. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2020 Sep; 37(9):1437-1448. doi: 10.1080/19440049.2020.1778187. [PMID: 32530783]
  • Lin Zhang, Chen-Xiang Wang, Jing Wu, Tian-Yun Wang, Qiao-Qiao Zhong, Yan Du, Shuai Ji, Liang Wang, Meng-Zhe Guo, Sheng-Qiu Xu, Dao-Quan Tang. Metabolic profiling of mice plasma, bile, urine and feces after oral administration of two licorice flavonones. Journal of ethnopharmacology. 2020 Jul; 257(?):112892. doi: 10.1016/j.jep.2020.112892. [PMID: 32320727]
  • Gari Vidal Ccana-Ccapatinta, Jennyfer Andrea Aldana Mejía, Matheus Hikaru Tanimoto, Milton Groppo, Jean Carlos Andrade Sarmento de Carvalho, Jairo Kenupp Bastos. Dalbergia ecastaphyllum (L.) Taub. and Symphonia globulifera L.f.: The Botanical Sources of Isoflavonoids and Benzophenones in Brazilian Red Propolis. Molecules (Basel, Switzerland). 2020 Apr; 25(9):. doi: 10.3390/molecules25092060. [PMID: 32354180]
  • Hao Wang, Hu Shan, Haitao Lü. Preparative separation of liquiritigenin and glycyrrhetic acid from Glycyrrhiza uralensis Fisch using hydrolytic extraction combined with high-speed countercurrent chromatography. Biomedical chromatography : BMC. 2020 Apr; 34(4):e4788. doi: 10.1002/bmc.4788. [PMID: 31899545]
  • Kang Uk Kim, Sung-Jin Lee, Inhyung Lee. Development of an Improved Menopausal Symptom-Alleviating Licorice (Glycyrrhiza uralensis) by Biotransformation Using Monascus albidulus. Journal of microbiology and biotechnology. 2020 Feb; 30(2):178-186. doi: 10.4014/jmb.1909.09037. [PMID: 31752065]
  • Xiangsheng Zhao, Shihui Zhang, Dan Liu, Meihua Yang, Jianhe Wei. Analysis of Flavonoids in Dalbergia odorifera by Ultra-Performance Liquid Chromatography with Tandem Mass Spectrometry. Molecules (Basel, Switzerland). 2020 Jan; 25(2):. doi: 10.3390/molecules25020389. [PMID: 31963485]
  • Changcan Shi, Hongjuan Wu, Ke Xu, Ting Cai, Kunming Qin, Li Wu, Baochang Cai. Liquiritigenin-Loaded Submicron Emulsion Protects Against Doxorubicin-Induced Cardiotoxicity via Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Activity. International journal of nanomedicine. 2020; 15(?):1101-1115. doi: 10.2147/ijn.s235832. [PMID: 32110010]
  • Zhenlin Huang, Qing Zhao, Minwei Chen, Jingnan Zhang, Lili Ji. Liquiritigenin and liquiritin alleviated monocrotaline-induced hepatic sinusoidal obstruction syndrome via inhibiting HSP60-induced inflammatory injury. Toxicology. 2019 12; 428(?):152307. doi: 10.1016/j.tox.2019.152307. [PMID: 31589899]
  • Wei Li, Tae In Kim, Ji Hye Kim, Hwan-Suck Chung. Immune Checkpoint PD-1/PD-L1 CTLA-4/CD80 are Blocked by Rhus verniciflua Stokes and its Active Compounds. Molecules (Basel, Switzerland). 2019 Nov; 24(22):. doi: 10.3390/molecules24224062. [PMID: 31717574]
  • Vivek Kumar Yadav, Abha Mishra. In vitro & in silico study of hypoglycemic potential of Pterocarpus marsupium heartwood extract. Natural product research. 2019 Nov; 33(22):3298-3302. doi: 10.1080/14786419.2018.1471078. [PMID: 29726721]
  • Yi-Dan Zhang, Hai-Ying Li, Fan-Ye Liu, Jie Niu, Xiao Wang, Chao Liang, Hua Sun. [7-hydroxy sulfonation of liquiritigenin by recombinant SULT1A3 enzyme and HEK-SULT1A3 cells]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2019 Oct; 44(19):4249-4256. doi: 10.19540/j.cnki.cjcmm.20190726.202. [PMID: 31872706]
  • Minwei Chen, Chaochao Zhang, Jingnan Zhang, Guoyin Kai, Bin Lu, Zhenlin Huang, Lili Ji. The involvement of DAMPs-mediated inflammation in cyclophosphamide-induced liver injury and the protection of liquiritigenin and liquiritin. European journal of pharmacology. 2019 Aug; 856(?):172421. doi: 10.1016/j.ejphar.2019.172421. [PMID: 31136760]
  • Jun-Jin Liu, Yao Cheng, Yun-Yun Shao, Zhuang-Peng Chang, Yi-Ting Guo, Xiao-Juan Feng, Ding Xu, Jing-Ping Zhang, Yan Song, Rui-Gang Hou. Comparative pharmacokinetics and metabolites study of seven major bioactive components of Shaoyao-Gancao decoction in normal and polycystic ovary syndrome rats by ultra high pressure liquid chromatography with tandem mass spectrometry. Journal of separation science. 2019 Aug; 42(15):2534-2549. doi: 10.1002/jssc.201900002. [PMID: 31144455]
  • Xi Huang, Jianjun Xu, Juan He, Shaoqi Shi, Hongbin Yan, Jian Wang, Ping Ren. Pharmacokinetic study of the prokinetic ABCs liquiritigenin, naringenin and hesperitin following the oral administration of Si-Ni-San decoction to functional dyspepsia patients. Xenobiotica; the fate of foreign compounds in biological systems. 2019 Jun; 49(6):708-717. doi: 10.1080/00498254.2018.1493756. [PMID: 30286676]
  • You Jin Han, Bitna Kang, Eun-Ju Yang, Min-Koo Choi, Im-Sook Song. Simultaneous Determination and Pharmacokinetic Characterization of Glycyrrhizin, Isoliquiritigenin, Liquiritigenin, and Liquiritin in Rat Plasma Following Oral Administration of Glycyrrhizae Radix Extract. Molecules (Basel, Switzerland). 2019 May; 24(9):. doi: 10.3390/molecules24091816. [PMID: 31083444]
  • Marta Carnovali, Livio Luzi, Ileana Terruzzi, Giuseppe Banfi, Massimo Mariotti. Liquiritigenin Reduces Blood Glucose Level and Bone Adverse Effects in Hyperglycemic Adult Zebrafish. Nutrients. 2019 May; 11(5):. doi: 10.3390/nu11051042. [PMID: 31075971]
  • Aleksandra Golonko, Tomasz Pienkowski, Renata Swislocka, Ryszard Lazny, Marek Roszko, Wlodzimierz Lewandowski. Another look at phenolic compounds in cancer therapy the effect of polyphenols on ubiquitin-proteasome system. European journal of medicinal chemistry. 2019 Apr; 167(?):291-311. doi: 10.1016/j.ejmech.2019.01.044. [PMID: 30776692]
  • Xinrui Li, Jing Liu, Liang Ma, Ping Fu. Pharmacological urate-lowering approaches in chronic kidney disease. European journal of medicinal chemistry. 2019 Mar; 166(?):186-196. doi: 10.1016/j.ejmech.2019.01.043. [PMID: 30769179]
  • Pille Link, Michael Wink. Isoliquiritigenin exerts antioxidant activity in Caenorhabditis elegans via insulin-like signaling pathway and SKN-1. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Mar; 55(?):119-124. doi: 10.1016/j.phymed.2018.07.004. [PMID: 30668421]
  • Guangguo Tan, Xin Wang, Kui Liu, Xin Dong, Wenting Liao, Hong Wu. Correlation of drug-induced and drug-related ultra-high performance liquid chromatography-mass spectrometry serum metabolomic profiles yields discovery of effective constituents of Sini decoction against myocardial ischemia in rats. Food & function. 2018 Nov; 9(11):5528-5535. doi: 10.1039/c8fo01217b. [PMID: 30209468]
  • Zhenlin Huang, Yuchen Sheng, Minwei Chen, Zhanxia Hao, Feifei Hu, Lili Ji. Liquiritigenin and liquiritin alleviated MCT-induced HSOS by activating Nrf2 antioxidative defense system. Toxicology and applied pharmacology. 2018 09; 355(?):18-27. doi: 10.1016/j.taap.2018.06.014. [PMID: 29908794]
  • Yannan Li, Jing Ning, Yan Wang, Chao Wang, Chengpeng Sun, Xiaokui Huo, Zhenlong Yu, Lei Feng, Baojing Zhang, Xiangge Tian, Xiaochi Ma. Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicology letters. 2018 Sep; 294(?):27-36. doi: 10.1016/j.toxlet.2018.05.008. [PMID: 29753067]
  • Svetlana S Efimova, Anastasiia A Zakharova, Roman Ya Medvedev, Olga S Ostroumova. Ion Channels Induced by Antimicrobial Agents in Model Lipid Membranes are Modulated by Plant Polyphenols Through Surrounding Lipid Media. The Journal of membrane biology. 2018 08; 251(4):551-562. doi: 10.1007/s00232-018-0031-1. [PMID: 29549386]
  • Hazir Rahman, Ilyas Khan, Anwar Hussain, Abdelaaty Abdelaziz Shahat, Abdul Tawab, Muhammad Qasim, Muhammad Adnan, Mansour S Al-Said, Riaz Ullah, Shahid Niaz Khan. Glycyrrhiza glabra HPLC fractions: identification of Aldehydo Isoophiopogonone and Liquirtigenin having activity against multidrug resistant bacteria. BMC complementary and alternative medicine. 2018 May; 18(1):140. doi: 10.1186/s12906-018-2207-8. [PMID: 29720152]
  • Atieh Hajirahimkhan, Obinna Mbachu, Charlotte Simmler, Sarah G Ellis, Huali Dong, Dejan Nikolic, David C Lankin, Richard B van Breemen, Shao-Nong Chen, Guido F Pauli, Birgit M Dietz, Judy L Bolton. Estrogen Receptor (ER) Subtype Selectivity Identifies 8-Prenylapigenin as an ERβ Agonist from Glycyrrhiza inflata and Highlights the Importance of Chemical and Biological Authentication. Journal of natural products. 2018 04; 81(4):966-975. doi: 10.1021/acs.jnatprod.7b01070. [PMID: 29641206]
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