Aloeemodin (BioDeep_00000002576)

 

Secondary id: BioDeep_00000859686

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


InChI=1/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H

化学式: C15H10O5 (270.052821)
中文名称: 芦荟大黄素, 芦荟泻素, 芦荟大黄素
谱图信息: 最多检出来源 Viridiplantae(plant) 10.06%

分子结构信息

SMILES: C12C=C(C=C(O)C=1C(=O)C1=C(C=CC=C1O)C2=O)CO
InChI: InChI=1S/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H2

描述信息

Aloe emodin is a dihydroxyanthraquinone that is chrysazin carrying a hydroxymethyl group at position 3. It has been isolated from plant species of the genus Aloe. It has a role as an antineoplastic agent and a plant metabolite. It is a dihydroxyanthraquinone and an aromatic primary alcohol. It is functionally related to a chrysazin.
Aloe-emodin is a natural product found in Rhamnus davurica, Aloe succotrina, and other organisms with data available.
See also: Frangula purshiana Bark (part of).
Aloeemodin is found in green vegetables. Aloeemodin is found in aloes, also bark of cascara sagrada Rhamnus purshiana, Chinese rhubarb Rheum palmatum and Rheum undulatum (rhubarb).Aloe emodin is an anthraquinone present in aloe latex, an exudate from the aloe plant. It has a strong stimulant-laxative action. (Wikipedia
A dihydroxyanthraquinone that is chrysazin carrying a hydroxymethyl group at position 3. It has been isolated from plant species of the genus Aloe.
CONFIDENCE standard compound; INTERNAL_ID 1086; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5097; ORIGINAL_PRECURSOR_SCAN_NO 5094
CONFIDENCE standard compound; INTERNAL_ID 1086; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8556; ORIGINAL_PRECURSOR_SCAN_NO 8554
CONFIDENCE standard compound; INTERNAL_ID 1086; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8561; ORIGINAL_PRECURSOR_SCAN_NO 8559
CONFIDENCE standard compound; INTERNAL_ID 1086; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8572; ORIGINAL_PRECURSOR_SCAN_NO 8570
CONFIDENCE standard compound; INTERNAL_ID 1086; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5090; ORIGINAL_PRECURSOR_SCAN_NO 5089
CONFIDENCE standard compound; INTERNAL_ID 1086; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5096; ORIGINAL_PRECURSOR_SCAN_NO 5093
CONFIDENCE standard compound; INTERNAL_ID 1086; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5085; ORIGINAL_PRECURSOR_SCAN_NO 5082
CONFIDENCE standard compound; INTERNAL_ID 1086; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8558; ORIGINAL_PRECURSOR_SCAN_NO 8556
CONFIDENCE standard compound; INTERNAL_ID 1086; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8554; ORIGINAL_PRECURSOR_SCAN_NO 8550
CONFIDENCE standard compound; INTERNAL_ID 1086; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5082; ORIGINAL_PRECURSOR_SCAN_NO 5079
CONFIDENCE standard compound; INTERNAL_ID 1086; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5104; ORIGINAL_PRECURSOR_SCAN_NO 5099
CONFIDENCE standard compound; INTERNAL_ID 1086; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8540; ORIGINAL_PRECURSOR_SCAN_NO 8539
Aloe emodin is a hydroxyanthraquinone extracted from aloe leaves and has been shown to have anti-tumor activity in vitro and in vivo.
Aloe emodin is a hydroxyanthraquinone extracted from aloe leaves and has been shown to have anti-tumor activity in vitro and in vivo.

同义名列表

41 个代谢物同义名

InChI=1/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H; Diacerein impurity B, European Pharmacopoeia (EP) Reference Standard; 1,8-Dihydroxy-3-(hydroxymethyl)-anthracene-9,10-dione (Aloe-Emodin); 1,8-DIHYDROXY-3-(HYDROXYMETHYL)-9,10-DIHYDROANTHRACENE-9,10-DIONE; 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-hydroxymethyl-anthracene; 1,8-Dihydroxy-3-hydroxymethyl-9,10-anthracenedione, 9CI; 9,10-Anthracenedione, 1,8-dihydroxy-3-(hydroxymethyl)-; 1,8-dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione; 1,8-Dihydroxy-3-(hydroxymethyl)anthra-9,10-quinone #; 1,8-Dihydroxy-3-(hydroxymethyl)-9,10-anthracenedione; 1,8-Dihydroxy-3-(hydroxymethyl)anthra-9,10-quinone; Anthraquinone, 1,8-dihydroxy-3-(hydroxymethyl)-; ANTHRAQUINONE, 1,8-DIHYDROXY-3-HYDROXYMETHYL-; Anthraquinone,8-dihydroxy-3-(hydroxymethyl)-; 1,8-Dihydroxy-3-(hydroxymethyl)anthraquinone; DIHYDROXY-3-HYDROXYMETHYLANTHRAQUINONE, 1,8-; 4-08-00-03578 (Beilstein Handbook Reference); 1,8-dihydroxy-3-hydroxymethyl-anthraquinone; 1,8-Dihydroxy-3-hydroxymethylanthraquinone; 9, 1,8-dihydroxy-3-(hydroxymethyl)-; Aloe-emodin, analytical standard; 3-(Hydroxymethyl)chrysazin; Aloe-emodin, >=95\\% (HPLC); 3-Hydroxymethylchrysazine; 3-Hydroxymethylchrysazin; Aloe-Emodine,(S); ALOE-EMODIN [MI]; UNII-C8IYT9CR7C; Rhabarberone; Tox21_302400; Aloe-emodine; NCI60_003685; AloeEmodine; Aloe-emodin; Aloe-emodol; Aloe emodin; SMP2_000291; Rottlerin?; Aloeemodin; C8IYT9CR7C; EMODINE



数据库引用编号

34 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

160 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Huang-Fei Jin, Qian-Xue Shen, Ying Shi, Fang-Ming Liu, Bin Wang, Jun Cao, Li-Hong Ye. Magnetic-stirring-enhanced mechanical amorphous dispersion extraction for the hydrophobic phytochemical constituents using an aqueous solution from a medicinal plant. Journal of pharmaceutical and biomedical analysis. 2024 Aug; 245(?):116191. doi: 10.1016/j.jpba.2024.116191. [PMID: 38728950]
  • Xun Li, Minghe Yao, Lingling Li, Huifen Ma, Yiran Sun, Xiangpeng Lu, Weipeng Jing, Shanshan Nie. Aloe-emodin alleviates cerebral ischemia-reperfusion injury by regulating microglial polarization and pyroptosis through inhibition of NLRP3 inflammasome activation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155578. doi: 10.1016/j.phymed.2024.155578. [PMID: 38621328]
  • Wencheng Xu, Shuhe Chen, Xiaoqin Wang, Jinwen Min, Sachiko Tanaka, Kenji Onda, Kentaro Sugiyama, Haruki Yamada, Toshihiko Hirano. Cepharanthine synergistically promotes methylprednisolone pharmacodynamics against human peripheral blood mononuclear cells possibly via regulation of P-glycoprotein/glucocorticoid receptor translocation. BMC complementary medicine and therapies. 2024 May; 24(1):186. doi: 10.1186/s12906-024-04489-z. [PMID: 38734604]
  • Jiangping Yang, Liujie Qin, Shouchang Zhou, Jixing Li, Yu Tu, Minfeng Mo, Xuenian Liu, Jinglun Huang, Xiumei Qin, Aijun Jiao, Wei Wei, Peilin Yang. Network pharmacology, molecular docking and experimental study of CEP in nasopharyngeal carcinoma. Journal of ethnopharmacology. 2024 Apr; 323(?):117667. doi: 10.1016/j.jep.2023.117667. [PMID: 38159821]
  • Zhuo Liu, Shaoqin Shen, Yujie Wang, Shuqi Sun, Tong Yu, Yanhong Fu, Rong Zhou, Chunjin Li, Rui Cao, Yanshu Zhang, Nan Li, Liangdan Sun, Xiaoming Song. The genome of Stephania japonica provides insights into the biosynthesis of cepharanthine. Cell reports. 2024 Mar; 43(3):113832. doi: 10.1016/j.celrep.2024.113832. [PMID: 38381605]
  • Yunfang Yang, Changjiang Li, Sijin Yang, Zhuo Zhang, Xue Bai, Hongmei Tang, Jiang Huang. Cepharanthine maintains integrity of the blood-brain barrier (BBB) in stroke via the VEGF/VEGFR2/ZO-1 signaling pathway. Aging. 2024 Mar; 16(7):5905-5915. doi: 10.18632/aging.205678. [PMID: 38517394]
  • Liang Leng, Zhichao Xu, Bixia Hong, Binbin Zhao, Ya Tian, Can Wang, Lulu Yang, Zhongmei Zou, Lingyu Li, Ke Liu, Wanjun Peng, Jiangning Liu, Zhoujie An, Yalin Wang, Baozhong Duan, Zhigang Hu, Chuan Zheng, Sanyin Zhang, Xiaodong Li, Maochen Li, Zhaoyu Liu, Zenghao Bi, Tianxing He, Baimei Liu, Huahao Fan, Chi Song, Yigang Tong, Shilin Chen. Cepharanthine analogs mining and genomes of Stephania accelerate anti-coronavirus drug discovery. Nature communications. 2024 Feb; 15(1):1537. doi: 10.1038/s41467-024-45690-5. [PMID: 38378731]
  • Jiali Wu, Yaokun Pang, Dan Liu, Jianxia Sun, Weibin Bai. Photodynamic Inactivation of Staphylococcus aureus Using Aloe-emodin as Photosensitizer. Food research international (Ottawa, Ont.). 2024 Feb; 178(?):113959. doi: 10.1016/j.foodres.2024.113959. [PMID: 38309912]
  • Fang Zhang, Rui Wu, Yanfang Liu, Shu Dai, Xinyan Xue, Xiaohong Gong, Yunxia Li. Comparative Pharmacokinetic Study of Rhubarb Anthraquinones in Normal and Nonalcoholic Fatty Liver Disease Rats. European journal of drug metabolism and pharmacokinetics. 2024 Jan; 49(1):111-121. doi: 10.1007/s13318-023-00875-z. [PMID: 38112917]
  • Yichao Liang, Jun Li, Honglin Xu, Mingjie Pang, Changlei Hu, Xie Weng, Wei Xie. Cepharanthine suppresses proliferation and metastasis and enhances apoptosis by regulating JAK2/Stat3 pathway in hepatocellular carcinoma. Cellular and molecular biology (Noisy-le-Grand, France). 2023 Dec; 69(14):94-100. doi: 10.14715/cmb/2023.69.14.15. [PMID: 38279472]
  • Huijuan Lv, Jingjing Niu, Wenhao Pan, Yudong Wang, Lifang Wang, Meng Wang, Yali Shi, Guifang Zhang, Bandar Al Hamyari, Shaohua Wang, Xuefeng Li, Yanbin Shi. Stool-softening effect and action mechanism of free anthraquinones extracted from Rheum palmatum L. on water deficit-induced constipation in rats. Journal of ethnopharmacology. 2023 Oct; 319(Pt 3):117336. doi: 10.1016/j.jep.2023.117336. [PMID: 37907143]
  • Martyna Nowak-Perlak, Piotr Ziółkowski, Marta Woźniak. A promising natural anthraquinones mediated by photodynamic therapy for anti-cancer therapy. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Oct; 119(?):155035. doi: 10.1016/j.phymed.2023.155035. [PMID: 37603973]
  • Jun Chen, Cheng Lei Xia, Rui Dong, Xian Guo Liu, Jing Xia. Cepharanthine Inhibits Doxorubicin-Induced Cellular Senescence by Activating Autophagy via the mTOR Signaling Pathway. Discovery medicine. 2023 Oct; 35(178):777-786. doi: 10.24976/discov.med.202335178.72. [PMID: 37811615]
  • Meng Yu, Xin-Yu Kong, Tong-Tong Chen, Zhong-Mei Zou. In vivo metabolism combined network pharmacology to identify anti-constipation constituents in Aloe barbadensis Mill. Journal of ethnopharmacology. 2023 Sep; 319(Pt 1):117200. doi: 10.1016/j.jep.2023.117200. [PMID: 37726070]
  • YingZheng Wang, Tong Wang, HuaXin Wang, WeiDong Liu, Xiao Li, XiaoYan Wang, YaNan Zhang. A mechanistic updated overview on Cepharanthine as potential anticancer agent. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jul; 165(?):115107. doi: 10.1016/j.biopha.2023.115107. [PMID: 37423171]
  • Ke Liu, Bixia Hong, Shuqi Wang, Fuxing Lou, Yecheng You, Ruolan Hu, Amna Shafqat, Huahao Fan, Yigang Tong. Pharmacological Activity of Cepharanthine. Molecules (Basel, Switzerland). 2023 Jun; 28(13):. doi: 10.3390/molecules28135019. [PMID: 37446681]
  • Liangliang Shi, Shuaizhe Wang, Shangzu Zhang, Jiawei Wang, Yaping Chen, Yangyang Li, Zhiwei Liu, Sichen Zhao, Benjun Wei, Liying Zhang. Research progress on pharmacological effects and mechanisms of cepharanthine and its derivatives. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Jun; ?(?):. doi: 10.1007/s00210-023-02537-y. [PMID: 37338575]
  • Hanaa M Sayed, Mahmoud A Ramadan, Heba H Salem, Iqrar Ahmad, Harun Patel, Marwa A A Fayed. Phytochemical Investigation, In silico/In vivo Analgesic, and Anti-inflammatory Assessment of the Egyptian Cassia occidentalis L. Steroids. 2023 May; 196(?):109245. doi: 10.1016/j.steroids.2023.109245. [PMID: 37141980]
  • Aswad Khadilkar, Zoie L Bunch, Jessica Wagoner, Vandana Ravindran, Jessica M Oda, Warren S Vidar, Trevor N Clark, Preston K Manwill, Daniel A Todd, Sarah A Barr, Lauren K Olinger, Susan L Fink, Wendy K Strangman, Roger G Linington, John B MacMillan, Nadja B Cech, Stephen J Polyak. Modulation of in Vitro SARS-CoV-2 Infection by Stephania tetrandra and Its Alkaloid Constituents. Journal of natural products. 2023 Apr; 86(4):1061-1073. doi: 10.1021/acs.jnatprod.3c00159. [PMID: 37043739]
  • Si Li, Xi Wu, Yue Ma, Hua Zhang, Wen Chen. Prediction and verification of the active ingredients and potential targets of Erhuang Quzhi Granules on non-alcoholic fatty liver disease based on network pharmacology. Journal of ethnopharmacology. 2023 Apr; ?(?):116435. doi: 10.1016/j.jep.2023.116435. [PMID: 37023836]
  • Ya-Peng Liu, Wang Zhang, Xin-Jie Liu, Huan Wu, An Zhou. [Determination of complexation ability of rhubarb with copper ions by ultra-high performance liquid chromatography]. Se pu = Chinese journal of chromatography. 2023 Apr; 41(4):323-329. doi: 10.3724/sp.j.1123.2022.06020. [PMID: 37005919]
  • Fan Wu, Yan Wang, Quanxi Mei, Qinhua Chen, Chengpeng Sun, Xia Lv, Lei Feng, Chao Wang, Yanyan Zhang, Bangjiang Fang, Xiaokui Huo, Xiangge Tian, Xiaochi Ma. UGTs-mediated metabolic interactions contribute to enhanced anti-inflammation activity of Jinhongtang. Journal of ethnopharmacology. 2023 Mar; 304(?):116016. doi: 10.1016/j.jep.2022.116016. [PMID: 36535328]
  • Shanlin Chen, Xiaoxue Guan, Lei Xie, Chuanyu Liu, Chunhong Li, Min He, Jiahua Hu, Hui Fan, Quanwen Li, Liuping Xie, Mingqing Yang, Xiaoling Zhang, Shengjun Xiao, Jianhong Tang. Aloe-emodin targets multiple signaling pathways by blocking ubiquitin-mediated degradation of DUSP1 in nasopharyngeal carcinoma cells. Phytotherapy research : PTR. 2023 Mar; ?(?):. doi: 10.1002/ptr.7793. [PMID: 36866539]
  • Dongpeng Wang, Jufeng Duan, Xiao-Jing Chen, Kaiqi Liu, Yingying Guo, Run Shi, Sha Li, Ming Liu, Lijun Zhao, Bei Li, Hongtao Liu, Minglun Li, Yibin Feng, Hongliang Li, Xuanbin Wang. Pharmacokinetic characteristics of emodin in polygoni Multiflori Radix Praeparata. Journal of ethnopharmacology. 2023 Mar; 303(?):115945. doi: 10.1016/j.jep.2022.115945. [PMID: 36435407]
  • Ganesh Dakne, Mohamad Taleuzzaman, Mohammad Sarafroz, Pankaj Yadav, Yasmin Khatoon, Ziyaul Haque, Sufiyan Ahmad. Aloe-emodin quantification using HPTLC and RP-UHPLC in extracts and commercial herbal formulations: Evaluation of antimicrobial and antioxidant effects. Recent advances in anti-infective drug discovery. 2023 Feb; ?(?):. doi: 10.2174/2772434418666230222085606. [PMID: 36815640]
  • Lingling Wang, Guoying Zhou, Shuo Zhao, Yang Yang. Soluble protein content, bioactive compounds and the antioxidant activity in seeds of ten Rheum tanguticum lines from Qinghai-Tibet Plateau. Chemistry & biodiversity. 2023 Feb; ?(?):e202200901. doi: 10.1002/cbdv.202200901. [PMID: 36788177]
  • Di Liang, Qi Li, Lina Du, Guifang Dou. Pharmacological Effects and Clinical Prospects of Cepharanthine. Molecules (Basel, Switzerland). 2022 Dec; 27(24):. doi: 10.3390/molecules27248933. [PMID: 36558061]
  • Guorong Cheng, Zhiqiang Liu, Zhong Zheng, Fengrui Song, Xiaoyu Zhuang, Shu Liu. Cell Metabolomics Reveals the Potential Mechanism of Aloe Emodin and Emodin Inhibiting Breast Cancer Metastasis. International journal of molecular sciences. 2022 Nov; 23(22):. doi: 10.3390/ijms232213738. [PMID: 36430215]
  • Hai Shang, Yue Hu, Jingrong Li, Lingyu Li, Yu Tian, Xiaoxue Li, Qi Wu, Zhongmei Zou. The Synthesis and Biological Evaluation of Aloe-Emodin-Coumarin Hybrids as Potential Antitumor Agents. Molecules (Basel, Switzerland). 2022 Sep; 27(19):. doi: 10.3390/molecules27196153. [PMID: 36234685]
  • Fan Wu, Baojing Zhang, Yu Zhang, Ting Zhao, Yan Wang, Xiangge Tian, Chengpeng Sun, Bangjiang Fang, Xiaokui Huo, Xiaochi Ma. Simultaneous Determination of Ten Active Components From Jinhongtang Granule in Rat Plasma by LC-MS/MS and its Application to a Comparative Pharmacokinetic Study in Normal and Sepsis Rats In Vivo and In Vitro. Journal of chromatographic science. 2022 Aug; ?(?):. doi: 10.1093/chromsci/bmac043. [PMID: 35913259]
  • Xiang-Yan Wei, Jian-Dong Long, Jing-Rui Chai, Jing Chen, Jian-Ping Gao, Yu-Jun Wang, Jing-Gen Liu. Antinociceptive activities and mechanism of action of Cepharanthine. Biochemical and biophysical research communications. 2022 07; 614(?):219-224. doi: 10.1016/j.bbrc.2022.04.083. [PMID: 35636221]
  • H Fan, K Liu, B Hong, S He, P Han, M Li, S Wang, Y Tong. [Progress in the study of antiviral activity of cepharanthine against SARS-CoV-2]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2022 Jun; 42(6):955-956. doi: 10.12122/j.issn.1673-4254.2022.06.22. [PMID: 35790449]
  • Jian Li, Guangrui Chen, Zhiyun Meng, Zhuona Wu, Hui Gan, Xiaoxia Zhu, Peng Han, Taoyun Liu, Fanjun Wang, Ruolan Gu, Guifang Dou. Bioavailability Enhancement of Cepharanthine via Pulmonary Administration in Rats and Its Therapeutic Potential for Pulmonary Fibrosis Associated with COVID-19 Infection. Molecules (Basel, Switzerland). 2022 Apr; 27(9):. doi: 10.3390/molecules27092745. [PMID: 35566097]
  • Magdalena Westermann, Amma G Adomako-Bonsu, Solveig Thiele, Serhat Sezai Çiçek, Hans-Jörg Martin, Edmund Maser. Inhibition of human carbonyl reducing enzymes by plant anthrone and anthraquinone derivatives. Chemico-biological interactions. 2022 Feb; 354(?):109823. doi: 10.1016/j.cbi.2022.109823. [PMID: 35065925]
  • Ibrahim Morgan, Ludger A Wessjohann, Goran N Kaluđerović. In Vitro Anticancer Screening and Preliminary Mechanistic Study of A-Ring Substituted Anthraquinone Derivatives. Cells. 2022 01; 11(1):. doi: 10.3390/cells11010168. [PMID: 35011730]
  • Chwan-Fwu Lin, Shih-Yi Chuang, Tse-Hung Huang, Thi My Huyen Nguyen, Pei-Wen Wang, Ahmed Alalaiwe, Jia-You Fang. A systematic comparison of the effect of topically applied anthraquinone aglycones to relieve psoriasiform lesion: The evaluation of percutaneous absorption and anti-inflammatory potency. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jan; 145(?):112482. doi: 10.1016/j.biopha.2021.112482. [PMID: 34915669]
  • Shiqi Gao, Liuzhi Zhou, Jianan Lu, Yuanjian Fang, Haijian Wu, Weilin Xu, Yuanbo Pan, Junjie Wang, Xiaoyu Wang, Jianmin Zhang, Anwen Shao. Cepharanthine Attenuates Early Brain Injury after Subarachnoid Hemorrhage in Mice via Inhibiting 15-Lipoxygenase-1-Mediated Microglia and Endothelial Cell Ferroptosis. Oxidative medicine and cellular longevity. 2022; 2022(?):4295208. doi: 10.1155/2022/4295208. [PMID: 35186185]
  • Atsushi Hijikata, Clara Shionyu-Mitsuyama, Setsu Nakae, Masafumi Shionyu, Motonori Ota, Shigehiko Kanaya, Takatsugu Hirokawa, Shogo Nakajima, Koichi Watashi, Tsuyoshi Shirai. Evaluating cepharanthine analogues as natural drugs against SARS-CoV-2. FEBS open bio. 2022 01; 12(1):285-294. doi: 10.1002/2211-5463.13337. [PMID: 34850606]
  • Yuan Zhou, Rong Wu, Fei-Fei Cai, Wen-Jun Zhou, Yi-Yu Lu, Hui Zhang, Qi-Long Chen, Ming-Yu Sun, Shi-Bing Su. Development of a novel anti-liver fibrosis formula with luteolin, licochalcone A, aloe-emodin and acacetin by network pharmacology and transcriptomics analysis. Pharmaceutical biology. 2021 Dec; 59(1):1594-1606. doi: 10.1080/13880209.2021.1999275. [PMID: 34808067]
  • Caihong Lu, Jinpeng Zheng, Yaning Ding, Yuanyuan Meng, Fangyun Tan, Wei Gong, Xiaoyang Chu, Xiaolong Kong, Chunsheng Gao. Cepharanthine loaded nanoparticles coated with macrophage membranes for lung inflammation therapy. Drug delivery. 2021 Dec; 28(1):2582-2593. doi: 10.1080/10717544.2021.2009936. [PMID: 34866533]
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