Aloeemodin (BioDeep_00000859686)

Main id: BioDeep_00000002576

 

PANOMIX_OTCML-2023


代谢物信息卡片


InChI=1\C15H10O5\c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17\h1-5,16-18H,6H

化学式: C15H10O5 (270.0528)
中文名称: 芦荟大黄素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)CO
InChI: InChI=1S/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H2

描述信息

Aloe emodin is a hydroxyanthraquinone extracted from aloe leaves and has been shown to have anti-tumor activity in vitro and in vivo.
Aloe emodin is a hydroxyanthraquinone extracted from aloe leaves and has been shown to have anti-tumor activity in vitro and in vivo.

同义名列表

37 个代谢物同义名

InChI=1\C15H10O5\c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17\h1-5,16-18H,6H; 9,10-Anthracenedione, 1,8-dihydroxy-3-(hydroxymethyl)- (9CI); 9,10-Anthracenedione, 1,8-dihydroxy-3-(hydroxymethyl)-; 1,8-dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione; 1,8-Dihydroxy-3-(hydroxymethyl)-9,10-anthracenedione; 1,8-Dihydroxy-3-(hydroxymethyl)anthra-9,10-quinone; Anthraquinone, 1,8-dihydroxy-3-(hydroxymethyl)-; ANTHRAQUINONE, 1,8-DIHYDROXY-3-HYDROXYMETHYL-; 1,8-Dihydroxy-3-(hydroxymethyl)anthraquinone; 4-08-00-03578 (Beilstein Handbook Reference); 1,8-dihydroxy-3-hydroxymethyl-anthraquinone; 1,8-dihydroxy-3-methylol-9,10-anthraquinone; 1,8-Dihydroxy-3-hydroxymethylanthraquinone; 3-Hydroxymethylchrysazin; EINECS 207-571-7; NCGC00163510-02; NCGC00163510-01; aloe emodine; Rhabarberone; LMPK02000031; NCI60_003685; A7687_SIGMA; Aloe-emodin; Aloe emodin; BRN 2059062; AIDS-048396; SMP2_000291; CCRIS 3526; AIDS048396; Aloeemodin; NSC 38628; 481-72-1; NSC38628; EMODINE; C10294; 3-Hydroxymethylchrysazine; Aloe-emodin



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

86 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 17 ABCB1, AKT1, ANXA5, BCL2, CASP3, CASP8, CASP9, CCNB1, CDKN1A, MAPK14, MAPK8, MTOR, MYC, PIK3CA, PTGS2, TP53, VEGFA
Peripheral membrane protein 3 ANXA5, MTOR, PTGS2
Endoplasmic reticulum membrane 3 BCL2, MTOR, PTGS2
Nucleus 13 AKT1, BCL2, CASP3, CASP8, CASP9, CCNB1, CDKN1A, MAPK14, MAPK8, MTOR, MYC, TP53, VEGFA
cytosol 14 AKT1, ANXA5, BCL2, CASP3, CASP8, CASP9, CCNB1, CDKN1A, MAPK14, MAPK8, MTOR, PIK3CA, PRKCQ, TP53
dendrite 1 MTOR
nuclear body 1 CDKN1A
phagocytic vesicle 1 MTOR
centrosome 2 CCNB1, TP53
nucleoplasm 10 AKT1, CASP3, CASP8, CCNB1, CDKN1A, MAPK14, MAPK8, MTOR, MYC, TP53
Cell membrane 3 ABCB1, AKT1, TNF
Cytoplasmic side 1 MTOR
lamellipodium 3 AKT1, CASP8, PIK3CA
Multi-pass membrane protein 1 ABCB1
Golgi apparatus membrane 1 MTOR
Synapse 1 MAPK8
cell cortex 1 AKT1
cell surface 3 ABCB1, TNF, VEGFA
glutamatergic synapse 3 AKT1, CASP3, MAPK14
Golgi apparatus 1 VEGFA
Golgi membrane 1 MTOR
lysosomal membrane 1 MTOR
neuronal cell body 2 CASP3, TNF
postsynapse 1 AKT1
sarcolemma 1 ANXA5
Lysosome 1 MTOR
plasma membrane 5 ABCB1, AKT1, PIK3CA, PRKCQ, TNF
Membrane 9 ABCB1, AKT1, ANXA5, BCL2, CCNB1, MTOR, MYC, TP53, VEGFA
apical plasma membrane 1 ABCB1
axon 1 MAPK8
caveola 1 PTGS2
extracellular exosome 2 ABCB1, ANXA5
Lysosome membrane 1 MTOR
endoplasmic reticulum 4 BCL2, PTGS2, TP53, VEGFA
extracellular space 3 IL6, TNF, VEGFA
perinuclear region of cytoplasm 2 CDKN1A, PIK3CA
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 5 BCL2, CASP8, CASP9, MAPK14, TP53
protein-containing complex 8 AKT1, BCL2, CASP8, CASP9, CDKN1A, MYC, PTGS2, TP53
Microsome membrane 2 MTOR, PTGS2
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 2 IL6, VEGFA
extracellular region 5 ANXA5, IL6, MAPK14, TNF, VEGFA
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 3 BCL2, CASP8, MTOR
Mitochondrion matrix 1 TP53
mitochondrial matrix 2 CCNB1, TP53
transcription regulator complex 1 TP53
centriolar satellite 1 PRKCQ
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 ANXA5, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
microtubule cytoskeleton 1 AKT1
nucleolus 3 CDKN1A, MYC, TP53
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Apical cell membrane 1 ABCB1
Cell projection, lamellipodium 1 CASP8
Membrane raft 1 TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 ANXA5
spindle 1 AKT1
extracellular matrix 1 VEGFA
Nucleus, PML body 2 MTOR, TP53
PML body 2 MTOR, TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 ANXA5
secretory granule 1 VEGFA
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Zymogen granule membrane 1 ANXA5
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 2 MYC, TP53
phagocytic cup 1 TNF
cytoskeleton 1 CASP8
Nucleus, nucleolus 1 MYC
spindle pole 2 CCNB1, MAPK14
site of double-strand break 1 TP53
nuclear envelope 2 MTOR, MYC
Endomembrane system 1 MTOR
Nucleus, nucleoplasm 1 MYC
cell body 1 CASP8
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
endoplasmic reticulum lumen 2 IL6, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
RNA polymerase II transcription repressor complex 1 MYC
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
apoptosome 1 CASP9
outer kinetochore 1 CCNB1
vesicle membrane 1 ANXA5
[Isoform 1]: Nucleus 1 TP53
external side of apical plasma membrane 1 ABCB1
basal dendrite 1 MAPK8
CD95 death-inducing signaling complex 1 CASP8
death-inducing signaling complex 2 CASP3, CASP8
ripoptosome 1 CASP8
Rough endoplasmic reticulum 1 MYC
Cytoplasmic vesicle, phagosome 1 MTOR
cyclin-dependent protein kinase holoenzyme complex 1 CDKN1A
Myc-Max complex 1 MYC
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
cyclin B1-CDK1 complex 1 CCNB1
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2
PCNA-p21 complex 1 CDKN1A
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
caspase complex 1 CASP9
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
nucleoplasmic reticulum 1 MYC


文献列表

  • Huang-Fei Jin, Qian-Xue Shen, Ying Shi, Fang-Ming Liu, Bin Wang, Jun Cao, Li-Hong Ye. Magnetic-stirring-enhanced mechanical amorphous dispersion extraction for the hydrophobic phytochemical constituents using an aqueous solution from a medicinal plant. Journal of pharmaceutical and biomedical analysis. 2024 Aug; 245(?):116191. doi: 10.1016/j.jpba.2024.116191. [PMID: 38728950]
  • Xun Li, Minghe Yao, Lingling Li, Huifen Ma, Yiran Sun, Xiangpeng Lu, Weipeng Jing, Shanshan Nie. Aloe-emodin alleviates cerebral ischemia-reperfusion injury by regulating microglial polarization and pyroptosis through inhibition of NLRP3 inflammasome activation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155578. doi: 10.1016/j.phymed.2024.155578. [PMID: 38621328]
  • Jiali Wu, Yaokun Pang, Dan Liu, Jianxia Sun, Weibin Bai. Photodynamic Inactivation of Staphylococcus aureus Using Aloe-emodin as Photosensitizer. Food research international (Ottawa, Ont.). 2024 Feb; 178(?):113959. doi: 10.1016/j.foodres.2024.113959. [PMID: 38309912]
  • Fang Zhang, Rui Wu, Yanfang Liu, Shu Dai, Xinyan Xue, Xiaohong Gong, Yunxia Li. Comparative Pharmacokinetic Study of Rhubarb Anthraquinones in Normal and Nonalcoholic Fatty Liver Disease Rats. European journal of drug metabolism and pharmacokinetics. 2024 Jan; 49(1):111-121. doi: 10.1007/s13318-023-00875-z. [PMID: 38112917]
  • Huijuan Lv, Jingjing Niu, Wenhao Pan, Yudong Wang, Lifang Wang, Meng Wang, Yali Shi, Guifang Zhang, Bandar Al Hamyari, Shaohua Wang, Xuefeng Li, Yanbin Shi. Stool-softening effect and action mechanism of free anthraquinones extracted from Rheum palmatum L. on water deficit-induced constipation in rats. Journal of ethnopharmacology. 2023 Oct; 319(Pt 3):117336. doi: 10.1016/j.jep.2023.117336. [PMID: 37907143]
  • Martyna Nowak-Perlak, Piotr Ziółkowski, Marta Woźniak. A promising natural anthraquinones mediated by photodynamic therapy for anti-cancer therapy. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Oct; 119(?):155035. doi: 10.1016/j.phymed.2023.155035. [PMID: 37603973]
  • Meng Yu, Xin-Yu Kong, Tong-Tong Chen, Zhong-Mei Zou. In vivo metabolism combined network pharmacology to identify anti-constipation constituents in Aloe barbadensis Mill. Journal of ethnopharmacology. 2023 Sep; 319(Pt 1):117200. doi: 10.1016/j.jep.2023.117200. [PMID: 37726070]
  • Hanaa M Sayed, Mahmoud A Ramadan, Heba H Salem, Iqrar Ahmad, Harun Patel, Marwa A A Fayed. Phytochemical Investigation, In silico/In vivo Analgesic, and Anti-inflammatory Assessment of the Egyptian Cassia occidentalis L. Steroids. 2023 May; 196(?):109245. doi: 10.1016/j.steroids.2023.109245. [PMID: 37141980]
  • Si Li, Xi Wu, Yue Ma, Hua Zhang, Wen Chen. Prediction and verification of the active ingredients and potential targets of Erhuang Quzhi Granules on non-alcoholic fatty liver disease based on network pharmacology. Journal of ethnopharmacology. 2023 Apr; ?(?):116435. doi: 10.1016/j.jep.2023.116435. [PMID: 37023836]
  • Ya-Peng Liu, Wang Zhang, Xin-Jie Liu, Huan Wu, An Zhou. [Determination of complexation ability of rhubarb with copper ions by ultra-high performance liquid chromatography]. Se pu = Chinese journal of chromatography. 2023 Apr; 41(4):323-329. doi: 10.3724/sp.j.1123.2022.06020. [PMID: 37005919]
  • Fan Wu, Yan Wang, Quanxi Mei, Qinhua Chen, Chengpeng Sun, Xia Lv, Lei Feng, Chao Wang, Yanyan Zhang, Bangjiang Fang, Xiaokui Huo, Xiangge Tian, Xiaochi Ma. UGTs-mediated metabolic interactions contribute to enhanced anti-inflammation activity of Jinhongtang. Journal of ethnopharmacology. 2023 Mar; 304(?):116016. doi: 10.1016/j.jep.2022.116016. [PMID: 36535328]
  • Shanlin Chen, Xiaoxue Guan, Lei Xie, Chuanyu Liu, Chunhong Li, Min He, Jiahua Hu, Hui Fan, Quanwen Li, Liuping Xie, Mingqing Yang, Xiaoling Zhang, Shengjun Xiao, Jianhong Tang. Aloe-emodin targets multiple signaling pathways by blocking ubiquitin-mediated degradation of DUSP1 in nasopharyngeal carcinoma cells. Phytotherapy research : PTR. 2023 Mar; ?(?):. doi: 10.1002/ptr.7793. [PMID: 36866539]
  • Dongpeng Wang, Jufeng Duan, Xiao-Jing Chen, Kaiqi Liu, Yingying Guo, Run Shi, Sha Li, Ming Liu, Lijun Zhao, Bei Li, Hongtao Liu, Minglun Li, Yibin Feng, Hongliang Li, Xuanbin Wang. Pharmacokinetic characteristics of emodin in polygoni Multiflori Radix Praeparata. Journal of ethnopharmacology. 2023 Mar; 303(?):115945. doi: 10.1016/j.jep.2022.115945. [PMID: 36435407]
  • Ganesh Dakne, Mohamad Taleuzzaman, Mohammad Sarafroz, Pankaj Yadav, Yasmin Khatoon, Ziyaul Haque, Sufiyan Ahmad. Aloe-emodin quantification using HPTLC and RP-UHPLC in extracts and commercial herbal formulations: Evaluation of antimicrobial and antioxidant effects. Recent advances in anti-infective drug discovery. 2023 Feb; ?(?):. doi: 10.2174/2772434418666230222085606. [PMID: 36815640]
  • Lingling Wang, Guoying Zhou, Shuo Zhao, Yang Yang. Soluble protein content, bioactive compounds and the antioxidant activity in seeds of ten Rheum tanguticum lines from Qinghai-Tibet Plateau. Chemistry & biodiversity. 2023 Feb; ?(?):e202200901. doi: 10.1002/cbdv.202200901. [PMID: 36788177]
  • Guorong Cheng, Zhiqiang Liu, Zhong Zheng, Fengrui Song, Xiaoyu Zhuang, Shu Liu. Cell Metabolomics Reveals the Potential Mechanism of Aloe Emodin and Emodin Inhibiting Breast Cancer Metastasis. International journal of molecular sciences. 2022 Nov; 23(22):. doi: 10.3390/ijms232213738. [PMID: 36430215]
  • Hai Shang, Yue Hu, Jingrong Li, Lingyu Li, Yu Tian, Xiaoxue Li, Qi Wu, Zhongmei Zou. The Synthesis and Biological Evaluation of Aloe-Emodin-Coumarin Hybrids as Potential Antitumor Agents. Molecules (Basel, Switzerland). 2022 Sep; 27(19):. doi: 10.3390/molecules27196153. [PMID: 36234685]
  • Fan Wu, Baojing Zhang, Yu Zhang, Ting Zhao, Yan Wang, Xiangge Tian, Chengpeng Sun, Bangjiang Fang, Xiaokui Huo, Xiaochi Ma. Simultaneous Determination of Ten Active Components From Jinhongtang Granule in Rat Plasma by LC-MS/MS and its Application to a Comparative Pharmacokinetic Study in Normal and Sepsis Rats In Vivo and In Vitro. Journal of chromatographic science. 2022 Aug; ?(?):. doi: 10.1093/chromsci/bmac043. [PMID: 35913259]
  • Magdalena Westermann, Amma G Adomako-Bonsu, Solveig Thiele, Serhat Sezai Çiçek, Hans-Jörg Martin, Edmund Maser. Inhibition of human carbonyl reducing enzymes by plant anthrone and anthraquinone derivatives. Chemico-biological interactions. 2022 Feb; 354(?):109823. doi: 10.1016/j.cbi.2022.109823. [PMID: 35065925]
  • Ibrahim Morgan, Ludger A Wessjohann, Goran N Kaluđerović. In Vitro Anticancer Screening and Preliminary Mechanistic Study of A-Ring Substituted Anthraquinone Derivatives. Cells. 2022 01; 11(1):. doi: 10.3390/cells11010168. [PMID: 35011730]
  • Chwan-Fwu Lin, Shih-Yi Chuang, Tse-Hung Huang, Thi My Huyen Nguyen, Pei-Wen Wang, Ahmed Alalaiwe, Jia-You Fang. A systematic comparison of the effect of topically applied anthraquinone aglycones to relieve psoriasiform lesion: The evaluation of percutaneous absorption and anti-inflammatory potency. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jan; 145(?):112482. doi: 10.1016/j.biopha.2021.112482. [PMID: 34915669]
  • Yuan Zhou, Rong Wu, Fei-Fei Cai, Wen-Jun Zhou, Yi-Yu Lu, Hui Zhang, Qi-Long Chen, Ming-Yu Sun, Shi-Bing Su. Development of a novel anti-liver fibrosis formula with luteolin, licochalcone A, aloe-emodin and acacetin by network pharmacology and transcriptomics analysis. Pharmaceutical biology. 2021 Dec; 59(1):1594-1606. doi: 10.1080/13880209.2021.1999275. [PMID: 34808067]
  • Yitong Liu, Mapa S T Mapa, Robert L Sprando. Anthraquinones inhibit cytochromes P450 enzyme activity in silico and in vitro. Journal of applied toxicology : JAT. 2021 09; 41(9):1438-1445. doi: 10.1002/jat.4134. [PMID: 33438235]
  • Corrado L Galli, Serena Cinelli, Paola Ciliutti, Gloria Melzi, Marina Marinovich. Aloe-emodin, a hydroxyanthracene derivative, is not genotoxic in an in vivo comet test. Regulatory toxicology and pharmacology : RTP. 2021 Aug; 124(?):104967. doi: 10.1016/j.yrtph.2021.104967. [PMID: 34062205]
  • Hans Wilhelm Rauwald, Ralf Maucher, Gerd Dannhardt, Kenny Kuchta. Dihydroisocoumarins, Naphthalenes, and Further Polyketides from Aloe vera and A. plicatilis: Isolation, Identification and Their 5-LOX/COX-1 Inhibiting Potency. Molecules (Basel, Switzerland). 2021 Jul; 26(14):. doi: 10.3390/molecules26144223. [PMID: 34299499]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Ibrahim Halil Gecibesler, Faruk Disli, Sinan Bayindir, Mahmut Toprak, Ali Riza Tufekci, Ayse Sahin Yaglıoglu, Muhammed Altun, Alpaslan Kocak, Ibrahim Demirtas, Sevki Adem. The isolation of secondary metabolites from Rheum ribes L. and the synthesis of new semi-synthetic anthraquinones: Isolation, synthesis and biological activity. Food chemistry. 2021 Apr; 342(?):128378. doi: 10.1016/j.foodchem.2020.128378. [PMID: 33508903]
  • Yuan Gao, Xiaoyu Zhang, Ximeng Li, Ruijuan Qi, Yixin Han, Yuan Kang, Runlan Cai, Cheng Peng, Yun Qi. Aloe-emodin, a naturally occurring anthraquinone, is a highly potent mast cell stabilizer through activating mitochondrial calcium uniporter. Biochemical pharmacology. 2021 04; 186(?):114476. doi: 10.1016/j.bcp.2021.114476. [PMID: 33607072]
  • Mei-Yan Liu, Xiao-Li Pan, Xue-Bo Li, Bing Wu. [Study on the Antioxidant Activity of Aloe-Emodin Metal Complex]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 2021 Mar; 52(2):241-247. doi: 10.12182/20201160110. [PMID: 33829698]
  • Xiang Qiu, Heying Pei, Hengfan Ni, Zhengying Su, Yong Li, Zhuang Yang, Caixia Dou, Lijuan Chen, Li Wan. Design, synthesis and anti-inflammatory study of novel N-heterocyclic substituted Aloe-emodin derivatives. Chemical biology & drug design. 2021 02; 97(2):358-371. doi: 10.1111/cbdd.13788. [PMID: 32889741]
  • Yi Zhang, Ziqing Song, Shan Huang, Li Zhu, Tianyi Liu, Hongyan Shu, Lei Wang, Yi Huang, Yang Chen. Aloe emodin relieves Ang II-induced endothelial junction dysfunction via promoting ubiquitination mediated NLRP3 inflammasome inactivation. Journal of leukocyte biology. 2020 12; 108(6):1735-1746. doi: 10.1002/jlb.3ma0520-582r. [PMID: 32573820]
  • C S Sharanya, K G Arun, A Sabu, M Haridas. Aloe emodin shows high affinity to active site and low affinity to two other sites to result consummately reduced inhibition of lipoxygenase. Prostaglandins & other lipid mediators. 2020 10; 150(?):106453. doi: 10.1016/j.prostaglandins.2020.106453. [PMID: 32380176]
  • Zhen-Li Su, Peng-Zhou Hang, Juan Hu, Yu-Yang Zheng, Han-Qi Sun, Jing Guo, Ke-Yu Liu, Zhi-Min Du. Aloe-emodin exerts cholesterol-lowering effects by inhibiting proprotein convertase subtilisin/kexin type 9 in hyperlipidemic rats. Acta pharmacologica Sinica. 2020 Aug; 41(8):1085-1092. doi: 10.1038/s41401-020-0392-8. [PMID: 32203084]
  • Danting Li, Bo Lv, Di Wang, Doudou Xu, Siyuan Qin, Ying Zhang, Jie Chen, Wei Zhang, Zunjian Zhang, Fengguo Xu. Network Pharmacology and Bioactive Equivalence Assessment Integrated Strategy Driven Q-markers Discovery for Da-Cheng-Qi Decoction to Attenuate Intestinal Obstruction. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Jul; 72(?):153236. doi: 10.1016/j.phymed.2020.153236. [PMID: 32464544]
  • De-Ming Liu, Dong Yang, Chun-Yan Zhou, Jia-Si Wu, Guo-Lin Zhang, Ping Wang, Fei Wang, Xian-Li Meng. Aloe-emodin induces hepatotoxicity by the inhibition of multidrug resistance protein 2. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Mar; 68(?):153148. doi: 10.1016/j.phymed.2019.153148. [PMID: 32028185]
  • Xiaoxv Dong, Yawen Zeng, Yi Liu, Longtai You, Xingbin Yin, Jing Fu, Jian Ni. Aloe-emodin: A review of its pharmacology, toxicity, and pharmacokinetics. Phytotherapy research : PTR. 2020 Feb; 34(2):270-281. doi: 10.1002/ptr.6532. [PMID: 31680350]
  • Yingfu Chen, Burong Feng, Ye Yuan, Juan Hu, Wei Zhao, Huiwei Jiang, Wen Li, Ziyi Fan, Zhimin Du. Aloe Emodin Reduces Cardiac Inflammation Induced by a High-Fat Diet through the TLR4 Signaling Pathway. Mediators of inflammation. 2020; 2020(?):6318520. doi: 10.1155/2020/6318520. [PMID: 32089647]
  • Nuriye Akev, Eda Candoken, Serap Erdem Kuruca. Comparative Study on the Anticancer Drug Potential of a Lectin Purified from Aloe Vera and Aloe-Emodin. Asian Pacific journal of cancer prevention : APJCP. 2020 Jan; 21(1):99-106. doi: 10.31557/apjcp.2020.21.1.99. [PMID: 31983171]
  • Mahesh Sapkota, Saroj Kumar Shrestha, Ming Yang, Young Ran Park, Yunjo Soh. Aloe-emodin inhibits osteogenic differentiation and calcification of mouse vascular smooth muscle cells. European journal of pharmacology. 2019 Dec; 865(?):172772. doi: 10.1016/j.ejphar.2019.172772. [PMID: 31697934]
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