Pirinixic acid (BioDeep_00000002328)

   

human metabolite blood metabolite


代谢物信息卡片


2-({4-chloro-6-[(2,3-dimethylphenyl)amino]pyrimidin-2-yl}sulfanyl)acetic acid

化学式: C14H14ClN3O2S (323.0495214)
中文名称: [4-氯-6-(2,3-茬胺基)-2-嘧啶硫代]乙酸
谱图信息: 最多检出来源 Homo sapiens(blood) 50%

分子结构信息

SMILES: CC1=C(C)C(NC2=CC(Cl)=NC(SCC(O)=O)=N2)=CC=C1
InChI: InChI=1S/C14H14ClN3O2S/c1-8-4-3-5-10(9(8)2)16-12-6-11(15)17-14(18-12)21-7-13(19)20/h3-6H,7H2,1-2H3,(H,19,20)(H,16,17,18)

描述信息

2-methylthioribosyl-trans-zeatin, also known as wy-14,643 or cxpta, is a member of the class of compounds known as aryl thioethers. Aryl thioethers are organosulfur compounds containing a thioether group that is substituted by an aryl group. 2-methylthioribosyl-trans-zeatin is practically insoluble (in water) and a weakly acidic compound (based on its pKa). 2-methylthioribosyl-trans-zeatin can be found in common pea and common wheat, which makes 2-methylthioribosyl-trans-zeatin a potential biomarker for the consumption of these food products.
CONFIDENCE standard compound; INTERNAL_ID 293; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9387; ORIGINAL_PRECURSOR_SCAN_NO 9382
CONFIDENCE standard compound; INTERNAL_ID 293; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9350; ORIGINAL_PRECURSOR_SCAN_NO 9349
CONFIDENCE standard compound; INTERNAL_ID 293; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4901; ORIGINAL_PRECURSOR_SCAN_NO 4897
CONFIDENCE standard compound; INTERNAL_ID 293; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4896; ORIGINAL_PRECURSOR_SCAN_NO 4894
CONFIDENCE standard compound; INTERNAL_ID 293; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9397; ORIGINAL_PRECURSOR_SCAN_NO 9396
CONFIDENCE standard compound; INTERNAL_ID 293; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4984; ORIGINAL_PRECURSOR_SCAN_NO 4982
CONFIDENCE standard compound; INTERNAL_ID 293; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9362; ORIGINAL_PRECURSOR_SCAN_NO 9360
CONFIDENCE standard compound; INTERNAL_ID 293; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9288; ORIGINAL_PRECURSOR_SCAN_NO 9287
CONFIDENCE standard compound; INTERNAL_ID 293; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4364; ORIGINAL_PRECURSOR_SCAN_NO 4363
CONFIDENCE standard compound; INTERNAL_ID 293; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9321; ORIGINAL_PRECURSOR_SCAN_NO 9318
CONFIDENCE standard compound; INTERNAL_ID 293; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4386; ORIGINAL_PRECURSOR_SCAN_NO 4382
CONFIDENCE standard compound; INTERNAL_ID 293; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4906; ORIGINAL_PRECURSOR_SCAN_NO 4904
Pirinixic acid (Wy-14643) is a potent agonist of PPARα, with EC50s of 0.63 μM, 32 μM for murine PPARα and PPARγ, and 5.0 μM, 60 μM, 35 μM for human PPARα, PPARγ and PPARδ, respectively.

同义名列表

17 个代谢物同义名

2-({4-chloro-6-[(2,3-dimethylphenyl)amino]pyrimidin-2-yl}sulfanyl)acetic acid; ((4-Chloro-6-((2,3-dimethylphenyl)amino)-2-pyrimidinyl)thio)acetic acid; ((4-Chloro-6-((2,3-dimethylphenyl)amino)-2-pyrimidinyl)thio)acetate; 4-Chloro-6-(2,3-dimethylphenyl)amino-2-pyrimidinylthioacetic acid; (4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio)acetic acid; 4-Chloro-6-(2,3-xylidinyl)-2-pyrimidinylthioacetic acid; (4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio)acetate; 2-Methylthioribosyl-trans-zeatin; Pirinixic acid; Wyeth 14,643; Wyeth-14643; Pirinixate; WY-14,643; CXPTA; [[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-acetic acid; Wy-14643; Wy 14643



数据库引用编号

27 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • G De Soricellis, F Rinaldi, S Tengattini, C Temporini, S Negri, D Capelli, R Montanari, H Cena, S Salerno, G Massolini, F Guzzo, E Calleri. Development of an analytical platform for the affinity screening of natural extracts by SEC-MS towards PPARα and PPARγ receptors. Analytica chimica acta. 2024 Jun; 1309(?):342666. doi: 10.1016/j.aca.2024.342666. [PMID: 38772654]
  • Chen Cao, Qingyuan Yang, Xiaoshuang Xia, Zhuangzhuang Chen, Peilin Liu, Xiaowen Wu, Hu Hu, Zhongren Ding, Xin Li. WY-14643, a novel antiplatelet and antithrombotic agent targeting the GPIbα receptor. Thrombosis research. 2024 Jun; 238(?):41-51. doi: 10.1016/j.thromres.2024.04.011. [PMID: 38669962]
  • Donghwan Kim, Sang Keun Ha, Frank J Gonzalez. CBFA2T3 Is PPARA Sensitive and Attenuates Fasting-Induced Lipid Accumulation in Mouse Liver. Cells. 2024 May; 13(10):. doi: 10.3390/cells13100831. [PMID: 38786053]
  • Yong Fan, Jing Lu, Jinghui Fan, Shuang Guan. 1,3-dichloro-2-propanol caused lipid droplets accumulation by suppressing neutral lipases via BMAL1 in hepatocytes. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 Feb; 174(?):113670. doi: 10.1016/j.fct.2023.113670. [PMID: 36805544]
  • Jie Yang, Shicheng Fan, Yifei Zhang, Min Huang, Yue Gao, Huichang Bi. Chronic Treatment With WY-14643 Induces Tumorigenesis and Triglyceride Accumulation in Mouse Livers. Drug metabolism and disposition: the biological fate of chemicals. 2022 12; 50(12):1464-1471. doi: 10.1124/dmd.122.000908. [PMID: 36184081]
  • Rui Wang, Jun Zhao, Jiacheng Jin, Yun Tian, Lan Lan, Xuejian Wang, Liang Zhu, Jianbo Wang. WY-14643 attenuates lipid deposition via activation of the PPARα/CPT1A axis by targeting Gly335 to inhibit cell proliferation and migration in ccRCC. Lipids in health and disease. 2022 Nov; 21(1):121. doi: 10.1186/s12944-022-01726-7. [PMID: 36384580]
  • Yunhui Xu, Krista L Denning, Yongke Lu. PPARα agonist WY-14,643 induces the PLA2/COX-2/ACOX1 pathway to enhance peroxisomal lipid metabolism and ameliorate alcoholic fatty liver in mice. Biochemical and biophysical research communications. 2022 07; 613(?):47-52. doi: 10.1016/j.bbrc.2022.04.132. [PMID: 35526488]
  • Sabina Sblano, Carmen Cerchia, Antonio Laghezza, Luca Piemontese, Leonardo Brunetti, Rosalba Leuci, Federica Gilardi, Aurelien Thomas, Massimo Genovese, Alice Santi, Paolo Tortorella, Paolo Paoli, Antonio Lavecchia, Fulvio Loiodice. A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivity. European journal of medicinal chemistry. 2022 May; 235(?):114240. doi: 10.1016/j.ejmech.2022.114240. [PMID: 35325635]
  • Cigdem Sahin, Lilia Magomedova, Thais A M Ferreira, Jiabao Liu, Jens Tiefenbach, Priscilla S Alves, Fellipe J G Queiroz, Andressa S de Oliveira, Mousumi Bhattacharyya, Julie Grouleff, Patrícia C N Nogueira, Edilberto R Silveira, Daniel C Moreira, José Roberto Souza de Almeida Leite, Guilherme D Brand, David Uehling, Gennady Poda, Henry Krause, Carolyn L Cummins, Luiz A S Romeiro. Phenolic Lipids Derived from Cashew Nut Shell Liquid to Treat Metabolic Diseases. Journal of medicinal chemistry. 2022 02; 65(3):1961-1978. doi: 10.1021/acs.jmedchem.1c01542. [PMID: 35089724]
  • Shicheng Fan, Yue Gao, Aijuan Qu, Yiming Jiang, Hua Li, Guomin Xie, Xinpeng Yao, Xiao Yang, Shuguang Zhu, Tomoki Yagai, Jianing Tian, Ruimin Wang, Frank J Gonzalez, Min Huang, Huichang Bi. YAP-TEAD mediates PPAR α-induced hepatomegaly and liver regeneration in mice. Hepatology (Baltimore, Md.). 2022 01; 75(1):74-88. doi: 10.1002/hep.32105. [PMID: 34387904]
  • Yunhui Xu, Krista L Denning, Yongke Lu. PPARα agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1. Biochemical pharmacology. 2021 10; 192(?):114678. doi: 10.1016/j.bcp.2021.114678. [PMID: 34265279]
  • Xue Chen, Yunhui Xu, Krista L Denning, Audrey Grigore, Yongke Lu. PPARα agonist WY-14,643 enhances ethanol metabolism in mice: Role of catalase. Free radical biology & medicine. 2021 06; 169(?):283-293. doi: 10.1016/j.freeradbiomed.2021.04.018. [PMID: 33892114]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Guozhu Ye, Bi-Cheng Yang, Han Gao, Zeming Wu, Jinsheng Chen, Xiao-Yan Ai, Qiansheng Huang. Metabolomics Insights into Oleate-Induced Disorders of Phospholipid Metabolism in Macrophages. The Journal of nutrition. 2021 03; 151(3):503-512. doi: 10.1093/jn/nxaa411. [PMID: 33571370]
  • Yu Yang, Yu Zhao, Wenzhen Li, Yuyao Wu, Xin Wang, Yijie Wang, Tingmei Liu, Tinghong Ye, Yongmei Xie, Zhiqiang Cheng, Jun He, Peng Bai, Yiwen Zhang, Liang Ouyang. Emerging targets and potential therapeutic agents in non-alcoholic fatty liver disease treatment. European journal of medicinal chemistry. 2020 Jul; 197(?):112311. doi: 10.1016/j.ejmech.2020.112311. [PMID: 32339855]
  • Yanfeng Xue, Changzheng Guo, Fan Hu, Weiyun Zhu, Shengyong Mao. PPARA/RXRA signalling regulates the fate of hepatic non-esterified fatty acids in a sheep model of maternal undernutrition. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2020 02; 1865(2):158548. doi: 10.1016/j.bbalip.2019.158548. [PMID: 31676441]
  • Yumiko Mizukawa, Yoko Amagase, Tetsuro Urushidani. Extraction of peroxisome proliferator-activated receptor α agonist-induced lipid metabolism-related and unrelated genes in rat liver and analysis of their genomic location. The Journal of toxicological sciences. 2020; 45(8):449-473. doi: 10.2131/jts.45.449. [PMID: 32741897]
  • Lujin Wu, Wei Wang, Meiyan Dai, Huihui Li, Chen Chen, Daowen Wang. PPARα ligand, AVE8134, and cyclooxygenase inhibitor therapy synergistically suppress lung cancer growth and metastasis. BMC cancer. 2019 Dec; 19(1):1166. doi: 10.1186/s12885-019-6379-5. [PMID: 31791289]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Henriette Arnesen, Nadia Nabil Haj-Yasein, Jørn E Tungen, Helen Soedling, Jason Matthews, Steinar M Paulsen, Hilde I Nebb, Ingebrigt Sylte, Trond Vidar Hansen, Thomas Sæther. Molecular modelling, synthesis, and biological evaluations of a 3,5-disubstituted isoxazole fatty acid analogue as a PPARα-selective agonist. Bioorganic & medicinal chemistry. 2019 09; 27(18):4059-4068. doi: 10.1016/j.bmc.2019.07.032. [PMID: 31351846]
  • Almudena Bermejo, Aida Collado, Isabel Barrachina, Patrice Marqués, Noureddine El Aouad, Xavier Franck, Francisco Garibotto, Catherine Dacquet, Daniel H Caignard, Fernando D Suvire, Ricardo D Enriz, Laura Piqueras, Bruno Figadère, María-Jesús Sanz, Nuria Cabedo, Diego Cortes. Polycerasoidol, a Natural Prenylated Benzopyran with a Dual PPARα/PPARγ Agonist Activity and Anti-inflammatory Effect. Journal of natural products. 2019 07; 82(7):1802-1812. doi: 10.1021/acs.jnatprod.9b00003. [PMID: 31268307]
  • Sungjin Ahn, Jungmin Kim, Seungchan An, Jeong Joo Pyo, Daram Jung, Joochang Lee, Seok Young Hwang, Junpyo Gong, Iljin Shin, Hong Pyo Kim, Hyoungsu Kim, Minsoo Noh. 2-Phenyl-8-(1-phenylallyl)-chromenone compounds have a pan-PPAR modulator pharmacophore. Bioorganic & medicinal chemistry. 2019 07; 27(13):2948-2958. doi: 10.1016/j.bmc.2019.05.028. [PMID: 31128991]
  • Xiaoting Jin, Bin Xue, Rifat Zubair Ahmed, Guobin Ding, Zhuoyu Li. Fine particles cause the abnormality of cardiac ATP levels via PPARɑ-mediated utilization of fatty acid and glucose using in vivo and in vitro models. Environmental pollution (Barking, Essex : 1987). 2019 Jun; 249(?):286-294. doi: 10.1016/j.envpol.2019.02.083. [PMID: 30897468]
  • Letizia Giampietro, Antonio Laghezza, Carmen Cerchia, Rosalba Florio, Lucia Recinella, Fabio Capone, Alessandra Ammazzalorso, Isabella Bruno, Barbara De Filippis, Marialuigia Fantacuzzi, Claudio Ferrante, Cristina Maccallini, Paolo Tortorella, Fabio Verginelli, Luigi Brunetti, Alessandro Cama, Rosa Amoroso, Fulvio Loiodice, Antonio Lavecchia. Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome. ACS medicinal chemistry letters. 2019 Apr; 10(4):545-551. doi: 10.1021/acsmedchemlett.8b00574. [PMID: 30996794]
  • Guozhu Ye, Han Gao, Yi Lin, Dongxiao Ding, Xu Liao, Han Zhang, Yulang Chi, Sijun Dong. Peroxisome proliferator-activated receptor A/G reprogrammes metabolism associated with lipid accumulation in macrophages. Metabolomics : Official journal of the Metabolomic Society. 2019 03; 15(3):36. doi: 10.1007/s11306-019-1485-6. [PMID: 30830452]
  • Vegard Lysne, Bodil Bjørndal, Mari Lausund Grinna, Øivind Midttun, Per Magne Ueland, Rolf Kristian Berge, Jutta Dierkes, Ottar Nygård, Elin Strand. Short-term treatment with a peroxisome proliferator-activated receptor α agonist influences plasma one-carbon metabolites and B-vitamin status in rats. PloS one. 2019; 14(12):e0226069. doi: 10.1371/journal.pone.0226069. [PMID: 31805132]
  • Sae On Kim, Yujia Han, Sungjin Ahn, Seungchan An, Jeayoung C Shin, Hyunjung Choi, Hyoung-June Kim, Nok Hyun Park, Yong-Jin Kim, Sun Hee Jin, Ho Sik Rho, Minsoo Noh. Kojyl cinnamate esters are peroxisome proliferator-activated receptor α/γ dual agonists. Bioorganic & medicinal chemistry. 2018 11; 26(21):5654-5663. doi: 10.1016/j.bmc.2018.10.010. [PMID: 30352713]
  • Belen Palomares, Francisco Ruiz-Pino, Carmen Navarrete, Inmaculada Velasco, Miguel A Sánchez-Garrido, Carla Jimenez-Jimenez, Carolina Pavicic, Maria J Vazquez, Giovanni Appendino, M Luz Bellido, Marco A Calzado, Manuel Tena-Sempere, Eduardo Muñoz. VCE-004.8, A Multitarget Cannabinoquinone, Attenuates Adipogenesis and Prevents Diet-Induced Obesity. Scientific reports. 2018 10; 8(1):16092. doi: 10.1038/s41598-018-34259-0. [PMID: 30382123]
  • Antonio Laghezza, Luca Piemontese, Carmen Cerchia, Roberta Montanari, Davide Capelli, Marco Giudici, Maurizio Crestani, Paolo Tortorella, Franck Peiretti, Giorgio Pochetti, Antonio Lavecchia, Fulvio Loiodice. Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation. Journal of medicinal chemistry. 2018 09; 61(18):8282-8298. doi: 10.1021/acs.jmedchem.8b00835. [PMID: 30199253]
  • Thomas Sæther, Steinar M Paulsen, Jørn E Tungen, Anders Vik, Marius Aursnes, Torgeir Holen, Trond Vidar Hansen, Hilde I Nebb. Synthesis and biological evaluations of marine oxohexadecenoic acids: PPARα/γ dual agonism and anti-diabetic target gene effects. European journal of medicinal chemistry. 2018 Jul; 155(?):736-753. doi: 10.1016/j.ejmech.2018.06.034. [PMID: 29940464]
  • Guolin Li, Chad N Brocker, Cen Xie, Tingting Yan, Audrey Noguchi, Kristopher W Krausz, Rong Xiang, Frank J Gonzalez. Hepatic peroxisome proliferator-activated receptor alpha mediates the major metabolic effects of Wy-14643. Journal of gastroenterology and hepatology. 2018 May; 33(5):1138-1145. doi: 10.1111/jgh.14046. [PMID: 29141109]
  • Ireen Vieweg, Eider Bilbao, James P Meador, Ibon Cancio, Morgan Lizabeth Bender, Miren P Cajaraville, Jasmine Nahrgang. Effects of dietary crude oil exposure on molecular and physiological parameters related to lipid homeostasis in polar cod (Boreogadus saida). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2018 Apr; 206-207(?):54-64. doi: 10.1016/j.cbpc.2018.03.003. [PMID: 29555404]
  • Hui Chen, Ricky Y K Man, Susan W S Leung. PPAR-α agonists acutely inhibit Ca2+-independent PLA2 to reduce H2O2-induced contractions in aortae of spontaneously hypertensive rats. American journal of physiology. Heart and circulatory physiology. 2018 03; 314(3):H681-H691. doi: 10.1152/ajpheart.00314.2017. [PMID: 29127234]
  • Celine Pirat, Catherine Dacquet, Veronique Leclerc, Nathalie Hennuyer, Monique Beucher-Gaudin, Ghislaine Zanirato, Anne Géant, Bart Staels, Alain Ktorza, Amaury Farce, Daniel-Henri Caignard, Pascal Berthelot, Nicolas Lebegue. Anti-diabetic activity of fused PPARγ-SIRT1 ligands with limited body-weight gain by mimicking calorie restriction and decreasing SGK1 expression. European journal of medicinal chemistry. 2017 Sep; 137(?):310-326. doi: 10.1016/j.ejmech.2017.06.006. [PMID: 28609708]
  • Mallory P Franklin, Aishwarya Sathyanarayan, Douglas G Mashek. Acyl-CoA Thioesterase 1 (ACOT1) Regulates PPARα to Couple Fatty Acid Flux With Oxidative Capacity During Fasting. Diabetes. 2017 08; 66(8):2112-2123. doi: 10.2337/db16-1519. [PMID: 28607105]
  • Kenta Takei, Song-Iee Han, Yuki Murayama, Aoi Satoh, Fusaka Oikawa, Hiroshi Ohno, Yoshinori Osaki, Takashi Matsuzaka, Motohiro Sekiya, Hitoshi Iwasaki, Shigeru Yatoh, Naoya Yahagi, Hiroaki Suzuki, Nobuhiro Yamada, Yoshimi Nakagawa, Hitoshi Shimano. Selective peroxisome proliferator-activated receptor-α modulator K-877 efficiently activates the peroxisome proliferator-activated receptor-α pathway and improves lipid metabolism in mice. Journal of diabetes investigation. 2017 Jul; 8(4):446-452. doi: 10.1111/jdi.12621. [PMID: 28084058]
  • Wei Zhang, Takashi Sakai, Sakuhei Fujiwara, Yutaka Hatano. Wy14643, an agonist for PPARα, downregulates expression of TARC and RANTES in cultured human keratinocytes. Experimental dermatology. 2017 05; 26(5):457-459. doi: 10.1111/exd.13245. [PMID: 27761952]
  • Zhong-Ze Fang, Naoki Tanaka, Dan Lu, Chang-Tao Jiang, Wei-Hua Zhang, Chunze Zhang, Zuo Du, Zhi-Wei Fu, Peng Gao, Yun-Feng Cao, Hong-Zhi Sun, Zhi-Tu Zhu, Yan Cai, Kristopher W Krausz, Zhi Yao, Frank J Gonzalez. Role of the lipid-regulated NF-κB/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury. Archives of toxicology. 2017 May; 91(5):2235-2244. doi: 10.1007/s00204-016-1877-6. [PMID: 27853831]
  • Yujung Jung, Yongkai Cao, Suresh Paudel, Goo Yoon, Seung Hoon Cheon, Gyu-Un Bae, Li Tai Jin, Yong Kee Kim, Su-Nam Kim. Antidiabetic effect of SN158 through PPARα/γ dual activation in ob/ob mice. Chemico-biological interactions. 2017 Apr; 268(?):24-30. doi: 10.1016/j.cbi.2017.02.014. [PMID: 28242381]
  • Taijyu Satoh, Kimio Satoh, Nobuhiro Yaoita, Nobuhiro Kikuchi, Junichi Omura, Ryo Kurosawa, Kazuhiko Numano, Elias Al-Mamun, Mohammad Abdul Hai Siddique, Shinichiro Sunamura, Masamichi Nogi, Kota Suzuki, Satoshi Miyata, John Morser, Hiroaki Shimokawa. Activated TAFI Promotes the Development of Chronic Thromboembolic Pulmonary Hypertension: A Possible Novel Therapeutic Target. Circulation research. 2017 Apr; 120(8):1246-1262. doi: 10.1161/circresaha.117.310640. [PMID: 28289017]
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