Baicalin (BioDeep_00000230240)

 

Secondary id: BioDeep_00000003537

natural product PANOMIX_OTCML-2023 Chemicals and Drugs


代谢物信息卡片


(2S,3S,4S,5R,6S)-6-((5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid

化学式: C21H18O11 (446.0849)
中文名称: 黄芩苷, 黄芩甙
谱图信息: 最多检出来源 Viridiplantae(plant) 20.7%

分子结构信息

SMILES: C(C(C(O)=O)4)(O)C(C(C(O4)Oc(c1O)cc(O2)c(C(=O)C=C(c(c3)cccc3)2)c1O)O)O
InChI: InChI=1S/C21H18O11/c22-9-6-10(8-4-2-1-3-5-8)30-11-7-12(14(23)15(24)13(9)11)31-21-18(27)16(25)17(26)19(32-21)20(28)29/h1-7,16-19,21,23-27H,(H,28,29)/t16-,17-,18+,19-,21+/m0/s1

描述信息

Baicalin is the glycosyloxyflavone which is the 7-O-glucuronide of baicalein. It is an active ingredient of Chinese herbal medicine Scutellaria baicalensis. It has a role as a non-steroidal anti-inflammatory drug, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor, a prodrug, a plant metabolite, a ferroptosis inhibitor, a neuroprotective agent, an antineoplastic agent, a cardioprotective agent, an antiatherosclerotic agent, an antioxidant, an EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitor, an anticoronaviral agent and an antibacterial agent. It is a glucosiduronic acid, a glycosyloxyflavone, a dihydroxyflavone and a monosaccharide derivative. It is functionally related to a baicalein. It is a conjugate acid of a baicalin(1-).
Baicalin is a natural product found in Scutellaria amoena, Thalictrum baicalense, and other organisms with data available.
See also: Scutellaria baicalensis Root (part of).
The glycosyloxyflavone which is the 7-O-glucuronide of baicalein. It is an active ingredient of Chinese herbal medicine Scutellaria baicalensis.
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D000890 - Anti-Infective Agents
D018501 - Antirheumatic Agents
D004791 - Enzyme Inhibitors
Baicalin, as a flavonoid glycoside, is an allosteric carnitine palmityl transferase 1 (CPT1) activator. Baicalin reduces the expression of NF-κB[1][2][3].
Baicalin, as a flavonoid glycoside, is an allosteric carnitine palmityl transferase 1 (CPT1) activator. Baicalin reduces the expression of NF-κB[1][2][3].

同义名列表

56 个代谢物同义名

(2S,3S,4S,5R,6S)-6-((5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid; (2S,3S,4S,5R,6S)-6-(5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)-3,4,5-trihydroxy-tetrahydro-2H-pyran-2-carboxylic acid; (2S,3S,4S,5R,6S)-6-(5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid; (2S,3S,4S,5R,6S)-6-(5,6-dihydroxy-4-oxo-2-phenyl-chromen-7-yl)oxy-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid; (2S,3S,4S,5R,6R)-6-(5,6-dihydroxy-4-oxo-2-phenyl-chromen-7-yl)oxy-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid; (2S,3S,4S,5R,6S)-6-[(5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid; (2S,3S,4S,5R,6S)-6-(5,6-DIHYDROXY-4-OXO-2-PHENYL-CHROMEN-7-YL)OXY-3,4,5-TRIHYDROXY-OXANE-2-CARBOXYLIC ACID; (2S,3S,4S,5R,6S)-6-(5,6-dihydroxy-4-oxo-2-phenylchromen-7-yl)oxy-3,4,5-trihydroxyoxane-2-carboxylicacid; .BETA.-D-GLUCOPYRANOSIDURONIC ACID, 5,6-DIHYDROXY-4-OXO-2-PHENYL-4H-1-BENZOPYRAN-7-YL; beta-D-Glucopyranosiduronic acid, 5,6-dihydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl; 5,6-dihydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl beta-D-glucopyranosiduronic acid; 5,6-Dihydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl |A-D-Glucopyranosiduronic Acid; 5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid; 5,6,7-Trihydroxyflavone-7-O-.beta.-D-glucopyranosideuronic acid; Baicalin, European Pharmacopoeia (EP) Reference Standard; 5,6,7-trihydroxyflavone 7-O-beta-D-glucuronide; 7-D-glucuronic acid-5,6-dihydroxy-flavone; Baicalein 7-beta-D-glucopyranosiduronate; 7-D-glucuronic acid-5,6-dihydroxyflavone; BAICALEIN 7-O-GLUCURONIDE [USP-RS]; Baicalein 7-O-.beta.-D-glucuronide; BAICALEIN 7-O-GLUCURONIDE (USP-RS); BAICALEIN 7-O-BETA-D-GLUCURONIDE; Baicalein 7-beta-D-glucuronide; Baicalein 7-O-b-D-glucuronide; IKIIZLYTISPENI-ZFORQUDYSA-N; Baicalein 7-O-glucuronide; Baicalin, >=99.0\\% (HPLC); Baicalein-7-D-glucuronide; Baicalein 7-glucuronide; BAICALIN [WHO-DD]; BAICALIN [VANDF]; BAICALIN [INCI]; Baicalin, 95\\%; Baicalin,(S); Baicaloside; Baicalin; baikalin; 0XE; (2S,3S,4S,5R,6S)-6-(5,6-dihydroxy-4-keto-2-phenyl-chromen-7-yl)oxy-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid; (2S,3S,4S,5R,6S)-6-[(5,6-dihydroxy-4-oxo-2-phenyl-7-chromenyl)oxy]-3,4,5-trihydroxy-2-tetrahydropyrancarboxylic acid; (2S,3S,4S,5R,6S)-6-(5,6-dihydroxy-4-oxo-2-phenylchromen-7-yl)oxy-3,4,5-trihydroxyoxane-2-carboxylic acid; 572667_ALDRICH; STOCK1N-21299; AIDS-001402; 100647-26-5; 31564-28-0; AIDS001402; CHEBI:2981; 21967-41-9; 27462-75-5; TJN-151; C10025; 5,6-Dihydroxyflavon-7-yl beta-D-glucopyranosiduronic acid; Baicalein 7-O-β-D-glucuronide; Baicalin



数据库引用编号

46 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

139 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 BDNF, EGFR, HSPA5, JAK2, NFKB1, NOS2, NOS3, PRKAA2, PTGS2, RB1, STAT3, TLR2, TLR4, VIM
Peripheral membrane protein 2 JAK2, PTGS2
Endosome membrane 2 EGFR, TLR4
Endoplasmic reticulum membrane 4 EGFR, HMOX1, HSPA5, PTGS2
Nucleus 12 EGFR, FOS, HMOX1, HSPA5, JAK2, NFKB1, NOS2, NOS3, PPARA, PRKAA2, RB1, STAT3
cytosol 12 FOS, HMOX1, HSPA5, IL1B, JAK2, NFKB1, NOS2, NOS3, PRKAA2, RB1, STAT3, VIM
dendrite 2 BDNF, PRKAA2
phagocytic vesicle 1 VIM
nucleoplasm 10 FOS, HMOX1, JAK2, NFKB1, NOS2, NOS3, PPARA, PRKAA2, RB1, STAT3
RNA polymerase II transcription regulator complex 2 FOS, STAT3
Cell membrane 3 EGFR, TLR4, VIM
Cytoplasmic side 1 HMOX1
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
cell junction 1 EGFR
cell surface 4 EGFR, HSPA5, TLR2, TLR4
glutamatergic synapse 2 EGFR, JAK2
Golgi apparatus 3 NOS3, PRKAA2, TLR2
Golgi membrane 2 EGFR, NOS3
neuronal cell body 1 PRKAA2
postsynapse 1 JAK2
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 2 IL1B, NOS2
Lysosome 1 IL1B
endosome 1 EGFR
plasma membrane 9 EGFR, HSPA5, JAK2, NOS2, NOS3, STAT3, TLR2, TLR4, VIM
Membrane 8 BDNF, EGFR, HMOX1, HSPA5, JAK2, PRKAA2, TLR2, TLR4
apical plasma membrane 1 EGFR
axon 3 BDNF, PRKAA2, VIM
basolateral plasma membrane 1 EGFR
caveola 3 JAK2, NOS3, PTGS2
extracellular exosome 2 HSPA5, VIM
endoplasmic reticulum 4 FOS, HMOX1, HSPA5, PTGS2
extracellular space 6 BDNF, CCL2, EGFR, HMOX1, IL1B, IL2
perinuclear region of cytoplasm 6 BDNF, EGFR, HMOX1, NOS2, NOS3, TLR4
mitochondrion 2 HSPA5, NFKB1
protein-containing complex 3 EGFR, HSPA5, PTGS2
intracellular membrane-bounded organelle 1 HSPA5
Microsome membrane 1 PTGS2
Single-pass type I membrane protein 3 EGFR, TLR2, TLR4
Secreted 4 BDNF, CCL2, IL1B, IL2
extracellular region 5 BDNF, CCL2, IL1B, IL2, NFKB1
cytoplasmic side of plasma membrane 1 JAK2
mitochondrial outer membrane 1 HMOX1
transcription regulator complex 2 NFKB1, STAT3
nuclear membrane 1 EGFR
external side of plasma membrane 1 TLR4
midbody 1 HSPA5
Cytoplasm, P-body 2 NOS2, NOS3
P-body 2 NOS2, NOS3
Early endosome 1 TLR4
Cytoplasm, perinuclear region 1 NOS2
Membrane raft 3 EGFR, JAK2, TLR2
Cytoplasm, cytoskeleton 1 VIM
focal adhesion 4 EGFR, HSPA5, JAK2, VIM
spindle 1 RB1
Peroxisome 2 NOS2, VIM
intracellular vesicle 1 EGFR
peroxisomal matrix 1 NOS2
PML body 1 RB1
secretory granule 1 IL1B
intermediate filament 1 VIM
nuclear speck 1 PRKAA2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 3 EGFR, TLR2, TLR4
neuron projection 2 PTGS2, VIM
chromatin 5 FOS, NFKB1, PPARA, RB1, STAT3
cell leading edge 1 VIM
Cytoplasmic vesicle, phagosome membrane 1 TLR2
cell projection 1 TLR2
phagocytic cup 1 TLR4
phagocytic vesicle membrane 1 TLR2
cytoskeleton 3 JAK2, NOS3, VIM
Endomembrane system 1 JAK2
endosome lumen 1 JAK2
microtubule organizing center 1 VIM
Melanosome 1 HSPA5
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 2 NOS3, PRKAA2
euchromatin 1 JAK2
cell body 1 TLR2
intermediate filament cytoskeleton 1 VIM
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
lipopolysaccharide receptor complex 1 TLR4
secretory granule lumen 1 NFKB1
secretory granule membrane 1 TLR2
endoplasmic reticulum lumen 3 BDNF, HSPA5, PTGS2
nuclear matrix 2 FOS, VIM
specific granule lumen 1 NFKB1
endocytic vesicle membrane 1 NOS3
Secreted, extracellular exosome 1 IL1B
SWI/SNF complex 1 RB1
Single-pass type IV membrane protein 1 HMOX1
Nucleus matrix 1 VIM
clathrin-coated endocytic vesicle membrane 1 EGFR
endoplasmic reticulum-Golgi intermediate compartment 1 HSPA5
extrinsic component of cytoplasmic side of plasma membrane 1 JAK2
protein-DNA complex 1 FOS
nucleotide-activated protein kinase complex 1 PRKAA2
Toll-like receptor 1-Toll-like receptor 2 protein complex 1 TLR2
Toll-like receptor 2-Toll-like receptor 6 protein complex 1 TLR2
extrinsic component of plasma membrane 1 JAK2
granulocyte macrophage colony-stimulating factor receptor complex 1 JAK2
interleukin-12 receptor complex 1 JAK2
interleukin-23 receptor complex 1 JAK2
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
transcription factor AP-1 complex 1 FOS
cortical cytoskeleton 1 NOS2
chromatin lock complex 1 RB1
Rb-E2F complex 1 RB1
endoplasmic reticulum chaperone complex 1 HSPA5
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF


文献列表

  • Yuan Gao, Yang-Yang Sun, Dong Bai, Xiao-Xia Wu. Mechanism of the components compatibility of Scutellariae Radix and Coptidis Rhizoma on mice with hyperlipidemia by regulating the Cyp4a family. Journal of ethnopharmacology. 2024 Sep; 331(?):118263. doi: 10.1016/j.jep.2024.118263. [PMID: 38677575]
  • Yanqin Luo, Bo Lin, Peng Yu, Di Zhang, Yingfan Hu, Xianli Meng, Li Xiang. Scutellaria baicalensis water decoction ameliorates lower respiratory tract infection by modulating respiratory microbiota. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155706. doi: 10.1016/j.phymed.2024.155706. [PMID: 38723528]
  • Kaili Liu, Ying Zhou, Xianrui Song, Jiahan Zeng, Zhuqi Wang, Ziqing Wang, Honglei Zhang, Jiaxing Xu, Wenting Li, Zixuan Gong, Min Wang, Baolin Liu, Na Xiao, Kang Liu. Baicalin attenuates neuronal damage associated with SDH activation and PDK2-PDH axis dysfunction in early reperfusion. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155570. doi: 10.1016/j.phymed.2024.155570. [PMID: 38579645]
  • Shunfen Zhang, Shanlong Tang, Zhengqun Liu, Huiyuan Lv, Xueying Cai, Ruqing Zhong, Liang Chen, Hongfu Zhang. Baicalin restore intestinal damage after early-life antibiotic therapy: the role of the MAPK signaling pathway. Pharmacological research. 2024 Jun; 204(?):107194. doi: 10.1016/j.phrs.2024.107194. [PMID: 38663526]
  • Lihua Shao, Li Zhu, Rong Su, Chunting Yang, Xiaqing Gao, Yan Xu, Hongwei Wang, Chenglong Guo, Hailong Li. Baicalin enhances the chemotherapy sensitivity of oxaliplatin-resistant gastric cancer cells by activating p53-mediated ferroptosis. Scientific reports. 2024 05; 14(1):10745. doi: 10.1038/s41598-024-60920-y. [PMID: 38730240]
  • Juyeong Cho, Eun-Bin Hong, Young-Sik Kim, Jungbin Song, Yeon Ha Ju, Hyunjin Kim, Hyowon Lee, Hocheol Kim, Min-Ho Nam. Baicalin and baicalein from Scutellaria baicalensis Georgi alleviate aberrant neuronal suppression mediated by GABA from reactive astrocytes. CNS neuroscience & therapeutics. 2024 05; 30(5):e14740. doi: 10.1111/cns.14740. [PMID: 38715318]
  • Yanfang Zheng, Chenxiang Wang, Wenjing Liu, Jiaying Chen, Yibin Sun, Dennis Chang, Huan Wang, Wen Xu, Jin-Jian Lu, Xian Zhou, Mingqing Huang. Upregulation of Nrf2 signaling: A key molecular mechanism of Baicalin's neuroprotective action against diabetes-induced cognitive impairment. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 May; 174(?):116579. doi: 10.1016/j.biopha.2024.116579. [PMID: 38631145]
  • Ying Cheng, Mengchao Yan, Shuyu He, Yi Xie, Lihui Wei, Bihan Xuan, Zucheng Shang, Meizhu Wu, Huifang Zheng, Youqin Chen, Meng Yuan, Jun Peng, Aling Shen. Baicalin alleviates angiotensin II-induced cardiomyocyte apoptosis and autophagy and modulates the AMPK/mTOR pathway. Journal of cellular and molecular medicine. 2024 May; 28(9):e18321. doi: 10.1111/jcmm.18321. [PMID: 38712979]
  • Shuangxiu Wan, Linzheng Wang, Zhili Hao, Lin Zhu, Xiaoxia Mao, Hongquan Li, Panpan Sun, Wei Yin, Kuohai Fan, Hailong Zhang, Beibei Li, Wansen Nie, Zongjie Li, Na Sun. Baicalin ameliorates the gut barrier function and intestinal microbiota of broiler chickens. Acta biochimica et biophysica Sinica. 2024 04; 56(4):634-644. doi: 10.3724/abbs.2024029. [PMID: 38511207]
  • Lin Zhang, Ceyu Miao, Zhixuan Wang, Xiulu Guan, Yechao Ma, Jingyu Song, Shiyuan Shen, Hongru Song, Mingqian Li, Cuizhe Liu. Preparation and characterisation of baicalin magnesium and its protective effect in ulcerative colitis via gut microbiota-bile acid axis modulation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Apr; 126(?):155416. doi: 10.1016/j.phymed.2024.155416. [PMID: 38394726]
  • Yucheng Yan, Safdar Ali Amur, Hong Liu, Ruoyao Shen, Huaiqing Sun, Yunlin Pei, Chaowan Guo, Hao Liang. Endogenous crude Scutellaria baicalensis polysaccharide robustly enhances one-pot extraction and deglycosylation of baicalin. International journal of biological macromolecules. 2024 Apr; 263(Pt 1):130349. doi: 10.1016/j.ijbiomac.2024.130349. [PMID: 38387634]
  • Wanting Fu, Ziyuan Liu, Yingzhou Wang, Xindi Li, Xiang Yu, Yang Li, Zejun Yu, Yinsheng Qiu, Zhinan Mei, Lingyun Xu. Baicalin inhibits monosodium urate crystal-induced pyroptosis in renal tubular epithelial cell line through Panx-1/P2X7 pathways: Molecular docking, molecular dynamics, and in vitro experiments. Chemical biology & drug design. 2024 Apr; 103(4):e14522. doi: 10.1111/cbdd.14522. [PMID: 38580458]
  • Xiaoxuan Zhao, Ying Zhao, Qujia Yang, Jing Ma, Yang Zhao, Suxia Wang, Yuepeng Jiang, Qin Zhang. Baicalin ameliorates deficient decidualization in URSA by regulating mitochondrial fission induced necroptosis. Biochimica et biophysica acta. Molecular cell research. 2024 Mar; 1871(3):119675. doi: 10.1016/j.bbamcr.2024.119675. [PMID: 38242329]
  • Lina Wan, Yuchen Li, Wenhao Liao, Lizhen Lei, Maoyuan Zhao, Jinhao Zeng, Ziyi Zhao, Jianyuan Tang. Synergistic inhibition effects of andrographolide and baicalin on coronavirus mechanisms by downregulation of ACE2 protein level. Scientific reports. 2024 02; 14(1):4287. doi: 10.1038/s41598-024-54722-5. [PMID: 38383655]
  • Haipeng Feng, Jingyan Zhang, Xuezhi Wang, Zhiting Guo, Lei Wang, Kang Zhang, Jianxi Li. Baicalin Protects Broilers against Avian Coronavirus Infection via Regulating Respiratory Tract Microbiota and Amino Acid Metabolism. International journal of molecular sciences. 2024 Feb; 25(4):. doi: 10.3390/ijms25042109. [PMID: 38396786]
  • Lingchao Miao, Xutao Zhang, Haolin Zhang, Meng Sam Cheong, Xiaojia Chen, Mohamed A Farag, Wai San Cheang, Jianbo Xiao. Baicalin ameliorates insulin resistance and regulates hepatic glucose metabolism via activating insulin signaling pathway in obese pre-diabetic mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Feb; 124(?):155296. doi: 10.1016/j.phymed.2023.155296. [PMID: 38176276]
  • Jun Chen, Chuhua Lin, Xiurong Huang, Wei Bian. Baicalin enhances proliferation and reduces inflammatory-oxidative stress effect in H2O2-induced granulosa cells apoptosis via USP48 protein regulation. BMC complementary medicine and therapies. 2024 Jan; 24(1):42. doi: 10.1186/s12906-024-04346-z. [PMID: 38245760]
  • Qirong Lu, Nan Wang, Defeng Wen, Pu Guo, Yu Liu, Shulin Fu, Chun Ye, Zhongyuan Wu, Yinsheng Qiu. Baicalin attenuates lipopolysaccharide-induced intestinal inflammatory injury via suppressing PARP1-mediated NF-κB and NLRP3 signalling pathway. Toxicon : official journal of the International Society on Toxinology. 2024 Jan; 239(?):107612. doi: 10.1016/j.toxicon.2024.107612. [PMID: 38211803]
  • Jiahua Huang, Xinyue Zhang, Xueping Yang, Qingyun Yv, Fanlong Ye, Sheng Chen, Ying Cui, Linting Gu, Min Zhu, Wenwei Li. Baicalin exerts neuroprotective actions by regulating the Nrf2-NLRP3 axis in toxin-induced models of Parkinson's disease. Chemico-biological interactions. 2024 Jan; 387(?):110820. doi: 10.1016/j.cbi.2023.110820. [PMID: 38016618]
  • Jiuxiang Liu, Hao Zhou, Jiangqi Chen, Qiang Zuo, Feng Liu. Baicalin inhibits IL-1β-induced ferroptosis in human osteoarthritis chondrocytes by activating Nrf-2 signaling pathway. Journal of orthopaedic surgery and research. 2024 Jan; 19(1):23. doi: 10.1186/s13018-023-04483-0. [PMID: 38166985]
  • Ruolei Wang, Chunyan Wang, Lianheng Lu, Fuwen Yuan, Feng He. Baicalin and baicalein in modulating tumor microenvironment for cancer treatment: A comprehensive review with future perspectives. Pharmacological research. 2024 Jan; 199(?):107032. doi: 10.1016/j.phrs.2023.107032. [PMID: 38061594]
  • Zhang Yu, Liu Xiaojia, Zhao Wei, Zhang Jian, Wang Aiting, Wang Jing, Yang Lin, Cao Bangwei, Yan Dan. Baicalin circumvents anti-PD-1 resistance by regulating the gut microbiota metabolite short-chain fatty acids. Pharmacological research. 2024 Jan; 199(?):107033. doi: 10.1016/j.phrs.2023.107033. [PMID: 38061593]
  • Hongtu Hu, Weiwei Li, Yiqun Hao, Zhuan Peng, Zhengping Zou, Wei Liang. Baicalin ameliorates renal fibrosis by upregulating CPT1α-mediated fatty acid oxidation in diabetic kidney disease. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 122(?):155162. doi: 10.1016/j.phymed.2023.155162. [PMID: 37922789]
  • Li Wang, Shenyi Huang, Xiaolun Liang, Junliang Zhou, Yifan Han, Jiangshan He, Danping Xu. Immuno-modulatory role of baicalin in atherosclerosis prevention and treatment: current scenario and future directions. Frontiers in immunology. 2024; 15(?):1377470. doi: 10.3389/fimmu.2024.1377470. [PMID: 38698839]
  • Tomasz Szkudelski, Katarzyna Szkudelska. The Anti-Diabetic Potential of Baicalin: Evidence from Rodent Studies. International journal of molecular sciences. 2023 Dec; 25(1):. doi: 10.3390/ijms25010431. [PMID: 38203600]
  • Haipeng Feng, Jingyan Zhang, Kang Zhang, Xuezhi Wang, Zhiting Guo, Lei Wang, Jianxi Li. Synergistic anti-infectious bronchitis virus activity of Phillygenin combined Baicalin by modulating respiratory microbiota and improving metabolic disorders. Poultry science. 2023 Dec; 103(2):103371. doi: 10.1016/j.psj.2023.103371. [PMID: 38150830]
  • Han-Young Kim, Jung-Hoon Kim. Chemical Characterization of the Precipitate Found in and Its Effect on Drug Release of the Scutellaria baicalensis -Coptis chinensis Extract. Chemistry & biodiversity. 2023 Nov; ?(?):e202301461. doi: 10.1002/cbdv.202301461. [PMID: 37961037]
  • Xiao-Yu Zheng, Ye-Hao Zhang, Wen-Ting Song, Guang-Yu Liu, Zhao Ding, Jian-Xun Liu. [Baicalin improves inflammatory response of human microglia by regulating cAMP-PKA-NF-κB/CREB pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Nov; 48(21):5863-5870. doi: 10.19540/j.cnki.cjcmm.20230614.704. [PMID: 38114182]
  • Gyeong Han Jeong, Hanui Lee, Hong-Ki Lee, Hyo Jin Choi, Byung Yeoup Chung, Hyoung-Woo Bai. Inhibitory effect of γ-ray-modified hydroxymethylated baicalins on NO production. Bioorganic & medicinal chemistry letters. 2023 Sep; 96(?):129491. doi: 10.1016/j.bmcl.2023.129491. [PMID: 37778427]
  • Qichao Hu, Shuyu Hou, Baoyi Xiong, Yueqiang Wen, Jundong Wang, Jinhao Zeng, Xiao Ma, Fang Wang. Therapeutic Effects of Baicalin on Diseases Related to Gut-Brain Axis Dysfunctions. Molecules (Basel, Switzerland). 2023 Sep; 28(18):. doi: 10.3390/molecules28186501. [PMID: 37764277]
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