Perillyl alcohol (BioDeep_00000229770)

Main id: BioDeep_00000000641

 

human metabolite PANOMIX_OTCML-2023 blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


1-cyclohexene-1-methanol, 4-(1-methylethenyl)-, (4S)-

化学式: C10H16O (152.1201)
中文名称: 紫苏醇, L-紫苏醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C=C(C)[C@@H]1CC=C(CC1)CO
InChI: InChI=1S/C10H16O/c1-8(2)10-5-3-9(7-11)4-6-10/h3,10-11H,1,4-7H2,2H3

描述信息

Perillyl alcohol is a limonene monoterpenoid consists of a cyclohexene ring substituted by a hydroxymethyl and a prop-1-en-2-yl group at positions 1 and 4 respectively. It is a constituent of a variety of essential oils including lavender. It has a role as a plant metabolite and a volatile oil component.
Perillyl alcohol is a natural product found in Trachyspermum anethifolium, Geum heterocarpum, and other organisms with data available.
Perillyl Alcohol is a naturally occurring monoterpene related to limonene with antineoplastic activity. Perillyl alcohol inhibits farnesyl transferase and geranylgeranyl transferase, thereby preventing post-translational protein farnesylation and isoprenylation and activation of oncoproteins such as p21-ras, and arresting tumor cells in the G1 phase of the cell cycle. (NCI04)
Perillyl alcohol is a monoterpene isolated from the essential oils of lavendin, peppermint, spearmint, cherries, celery seeds, and several other plants. In animal studies it has been shown to regress pancreatic, mammary, and liver tumors, to exhibit possible application as a chemopreventative agent for colon, skin, and lung cancer, and as a chemotherapeutic agent for neuroblastoma, and prostate and colon cancer.(PMID: 9855569) [HMDB]. p-Mentha-1,8-dien-7-ol is found in many foods, some of which are caraway, ginger, german camomile, and sweet bay.
Perillyl alcohol is a monoterpene isolated from the essential oils of lavendin, peppermint, spearmint, cherries, celery seeds, and several other plants. In animal studies it has been shown to regress pancreatic, mammary, and liver tumors, to exhibit possible application as a chemopreventative agent for colon, skin, and lung cancer, and as a chemotherapeutic agent for neuroblastoma, and prostate and colon cancer.(PMID:9855569).
A limonene monoterpenoid consists of a cyclohexene ring substituted by a hydroxymethyl and a prop-1-en-2-yl group at positions 1 and 4 respectively. It is a constituent of a variety of essential oils including lavender.
C471 - Enzyme Inhibitor > C2020 - Farnesyl Transferase Inhibitor
D000970 - Antineoplastic Agents
D004791 - Enzyme Inhibitors
(S)-(?)-Perillyl alcohol is a monoterpene found in lavender, inhibits farnesylation of Ras, upregulates the mannose-6-phosphate receptor and induces apoptosis. Anti-cancer activity[1].
(S)-(?)-Perillyl alcohol is a monoterpene found in lavender, inhibits farnesylation of Ras, upregulates the mannose-6-phosphate receptor and induces apoptosis. Anti-cancer activity[1].
Perillyl alcohol, a monoterpene,?is active in inducing apoptosis in tumor cells without affecting normal cells[1].
Perillyl alcohol, a monoterpene,?is active in inducing apoptosis in tumor cells without affecting normal cells[1].

同义名列表

54 个代谢物同义名

1-cyclohexene-1-methanol, 4-(1-methylethenyl)-, (4S)-; (+/-)-1-CYCLOHEXENE-1-METHANOL, 4-(1-METHYLETHENYL)-; (S)-[4-(1-Propen-2-yl)-1-cyclohexen-1-yl]methanol; Cyclohex-1-ene-1-methanol, 4-(1-methylethenyl)-; [4-(prop-1-en-2-yl)cyclohex-1-en-1-yl]methanol; (4-(Prop-1-en-2-yl)cyclohex-1-en-1-yl)methanol; 1-Cyclohexene-1-methanol, 4-(1-methylethenyl)-; cyclohex-1-ene-1-methanol, 4(1-methylethenyl); 4-(1-Methylethenyl)-1-cyclohexene-1-methanol; (4-(prop-1-en-2-yl)cyclohex-1-enyl)methanol; 1-Hydroxymethyl-4-isopropenyl-1-cyclohexene; (4-Isopropenyl-1-cyclohexen-1-yl)methanol; (4-prop-1-en-2-ylcyclohexen-1-yl)methanol; 4-Isopropenylcyclohex-1-en-1-ylmethanol; 4-isopropenyl-cyclohex-1-ene-1-methanol; 4-isopropenyl-cyclohex-1-enylmethanol; 4-Isopropenyl-1-cyclohexene-methanol; 4-Isopropenyl-1-cyclohexene carbinol; P-MENTHA-1,8-DIEN-7-OL [FHFI]; perilla alcohol, (S)-isomer; perilla alcohol, (R)-isomer; (-)-p-mentha-1,8-dien-7-ol; Para-mentha-1,8-dien-7-ol; (S)-(?)-Perillyl alcohol; (S)-(-)-Perillyl alcohol; STERCOBILINHYDROCHLORIDE; dihydrocuminyl alcoholn; BENCYNOATEHYDROCHLORIDE; PERILLYL ALCOHOL [INCI]; p-mentha-1,8-dien-7-ol; dihydrocuminyl alcohol; (+/-)-PERILLYL ALCOHOL; Dihydrocuminic alcohol; 1,8-p-Menthadien-7-ol; (-)-Perillyl alcohol; (S)-perillyl alcohol; Dl-perillyl alcohol; (-)-Perillylalcohol; Hydrocumin alcohol; Perillyl alcohol; Spectrum3_001974; Perillic alcohol; Spectrum2_000838; perilla alcohol; UNII:319R5C7293; 1-perillalcohol; perill alcohol; KBio3_002951; Iso-carveol; Isocarveol; Perillol; (S)-(-)-(4-Isopropenyl-1-cyclohexenyl)methanol; (-)-Perillyl alcohol; Perillyl alcohol



数据库引用编号

31 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

23 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 AKT1, ANG, BCL2, CASP3, CAT, CCND1, CDK2, EIF4EBP1, MTOR, MYC, ODC1, PTGS2, RHOA, TP53
Peripheral membrane protein 2 MTOR, PTGS2
Endoplasmic reticulum membrane 5 BCL2, HMGCR, MTOR, PTGS2, RHOA
Nucleus 13 AKT1, ANG, BCL2, CASP3, CCND1, CDK2, EIF4EBP1, GABPA, MTOR, MYC, PARP1, RHOA, TP53
cytosol 13 AKT1, ANG, BCL2, CASP3, CAT, CCND1, CDK2, EIF4EBP1, MTOR, ODC1, PARP1, RHOA, TP53
dendrite 1 MTOR
nuclear body 1 PARP1
phagocytic vesicle 1 MTOR
centrosome 4 CCND1, CDK2, SLC16A1, TP53
nucleoplasm 9 AKT1, CASP3, CCND1, CDK2, GABPA, MTOR, MYC, PARP1, TP53
Cell membrane 4 AKT1, RHOA, SLC16A1, TNF
Lipid-anchor 1 RHOA
Cytoplasmic side 2 MTOR, RHOA
Cleavage furrow 1 RHOA
lamellipodium 2 AKT1, RHOA
ruffle membrane 1 RHOA
Multi-pass membrane protein 2 HMGCR, SLC16A1
Golgi apparatus membrane 1 MTOR
Synapse 1 SLC16A1
cell cortex 2 AKT1, RHOA
cell junction 2 RHOA, SLC16A1
cell surface 1 TNF
glutamatergic synapse 3 AKT1, CASP3, RHOA
Golgi membrane 1 MTOR
growth cone 1 ANG
lysosomal membrane 1 MTOR
neuronal cell body 3 ANG, CASP3, TNF
postsynapse 2 AKT1, RHOA
Cytoplasm, cytosol 1 PARP1
Lysosome 1 MTOR
endosome 2 CDK2, RHOA
plasma membrane 4 AKT1, RHOA, SLC16A1, TNF
Membrane 9 AKT1, BCL2, CAT, HMGCR, MTOR, MYC, PARP1, SLC16A1, TP53
apical plasma membrane 1 SLC16A1
basolateral plasma membrane 1 SLC16A1
caveola 1 PTGS2
extracellular exosome 3 CAT, RHOA, SLC16A1
Lysosome membrane 1 MTOR
endoplasmic reticulum 4 BCL2, HMGCR, PTGS2, TP53
extracellular space 2 ANG, TNF
bicellular tight junction 1 CCND1
mitochondrion 4 BCL2, CAT, PARP1, TP53
protein-containing complex 7 AKT1, BCL2, CAT, MYC, PARP1, PTGS2, TP53
intracellular membrane-bounded organelle 2 CAT, SLC16A1
Microsome membrane 2 MTOR, PTGS2
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 1 ANG
extracellular region 3 ANG, CAT, TNF
cytoplasmic side of plasma membrane 1 RHOA
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, MTOR
Mitochondrion matrix 1 TP53
mitochondrial matrix 2 CAT, TP53
transcription regulator complex 3 CDK2, PARP1, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 CDK2, TP53
Nucleus membrane 2 BCL2, CCND1
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, CCND1
external side of plasma membrane 1 TNF
actin cytoskeleton 1 ANG
dendritic spine 1 RHOA
microtubule cytoskeleton 1 AKT1
nucleolus 4 ANG, MYC, PARP1, TP53
midbody 1 RHOA
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 2 AKT1, RHOA
Apical cell membrane 1 SLC16A1
Cell projection, lamellipodium 1 RHOA
Membrane raft 1 TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 2 CAT, RHOA
spindle 1 AKT1
Peroxisome 1 CAT
basement membrane 1 ANG
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 2 CAT, HMGCR
Nucleus, PML body 2 MTOR, TP53
PML body 2 MTOR, TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
lateral plasma membrane 1 SLC16A1
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 4 GABPA, MYC, PARP1, TP53
phagocytic cup 1 TNF
cell periphery 1 RHOA
Chromosome 2 ANG, PARP1
cytoskeleton 1 RHOA
Nucleus, nucleolus 3 ANG, MYC, PARP1
nuclear replication fork 1 PARP1
chromosome, telomeric region 2 CDK2, PARP1
Cytoplasm, cell cortex 1 RHOA
Basolateral cell membrane 1 SLC16A1
site of double-strand break 2 PARP1, TP53
nuclear envelope 4 CDK2, MTOR, MYC, PARP1
Endomembrane system 1 MTOR
Nucleus, nucleoplasm 1 MYC
Cell projection, dendrite 1 RHOA
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
Peroxisome membrane 1 HMGCR
basal plasma membrane 1 SLC16A1
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
secretory granule membrane 1 RHOA
endoplasmic reticulum lumen 1 PTGS2
nuclear matrix 1 TP53
transcription repressor complex 2 CCND1, TP53
male germ cell nucleus 1 CDK2
endocytic vesicle 1 ANG
RNA polymerase II transcription repressor complex 1 MYC
Cajal body 1 CDK2
[Isoform 1]: Nucleus 1 TP53
protein-DNA complex 1 PARP1
ficolin-1-rich granule membrane 1 RHOA
death-inducing signaling complex 1 CASP3
apical junction complex 1 RHOA
Rough endoplasmic reticulum 1 MYC
condensed chromosome 1 CDK2
Cytoplasmic vesicle, phagosome 1 MTOR
Nucleus, Cajal body 1 CDK2
X chromosome 1 CDK2
Y chromosome 1 CDK2
site of DNA damage 1 PARP1
cyclin-dependent protein kinase holoenzyme complex 2 CCND1, CDK2
cyclin E1-CDK2 complex 1 CDK2
cyclin E2-CDK2 complex 1 CDK2
Myc-Max complex 1 MYC
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
angiogenin-PRI complex 1 ANG
catalase complex 1 CAT
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CCND1
cyclin A2-CDK2 complex 1 CDK2
cyclin D1-CDK6 complex 1 CCND1
cyclin A1-CDK2 complex 1 CDK2
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
nucleoplasmic reticulum 1 MYC


文献列表

  • Eswara Rao Puppala, Siddhi Jain, Pritam Saha, Mahesh Rachamalla, Syamprasad Np, Sai Sudha Yalamarthi, Md Abubakar, Antra Chaudhary, D Chamundeswari, Murty Usn, Jagadeesh Kumar Gangasani, V G M Naidu. Perillyl alcohol attenuates rheumatoid arthritis via regulating TLR4/NF-κB and Keap1/Nrf2 signaling pathways: A comprehensive study onin-vitro and in-vivo experimental models. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Mar; 97(?):153926. doi: 10.1016/j.phymed.2022.153926. [PMID: 35030388]
  • Marcela de Oliveira Silva, Graziella Ribeiro de Sousa, Sarah Capelupe Simões, Patrícia Nicolucci, Edwin Tamashiro, Fabiano Saggioro, Ricardo Santos de Oliveira, María Sol Brassesco. Perillyl alcohol for pediatric TP53- and RAS-mutated SHH-medulloblastoma: an in vitro and in vivo translational pre-clinical study. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. 2021 07; 37(7):2163-2175. doi: 10.1007/s00381-021-05115-w. [PMID: 33885911]
  • Arlindo César Matias Pereira, Brenda Lorena Sánchez-Ortíz, Ester Lopes de Melo, Lorane Izabel da Silva Hage-Melim, Raphaelle Sousa Borges, Xuebo Hu, José Carlos Tavares Carvalho. Perillyl alcohol decreases the frequency and severity of convulsive-like behavior in the adult zebrafish model of acute seizures. Naunyn-Schmiedeberg's archives of pharmacology. 2021 06; 394(6):1177-1190. doi: 10.1007/s00210-021-02050-0. [PMID: 33515278]
  • Soodeh Rajabi, Hamid Najafipour, Saeideh Jafarinejad-Farsangi, Siyavash Joukar, Ahmad Beik, Majid Askaripour, Elham Jafari, Zohreh Safi. Quercetin, Perillyl Alcohol, and Berberine Ameliorate Right Ventricular Disorders in Experimental Pulmonary Arterial Hypertension: Effects on miR-204, miR-27a, Fibrotic, Apoptotic, and Inflammatory Factors. Journal of cardiovascular pharmacology. 2021 06; 77(6):777-786. doi: 10.1097/fjc.0000000000001015. [PMID: 34016844]
  • Juliane da Silva Santos, Camila Diedrich, Christiane Schineider Machado, Clovis Orlando da Fonseca, Najeh Maissar Khalil, Rubiana Mara Mainardes. Intranasal administration of perillyl alcohol-loaded nanoemulsion and pharmacokinetic study of its metabolite perillic acid in plasma and brain of rats using ultra-performance liquid chromatography/tandem mass spectrometry. Biomedical chromatography : BMC. 2021 Apr; 35(4):e5037. doi: 10.1002/bmc.5037. [PMID: 33238042]
  • Geetika Nehra, Shannon Andrews, Joan Rettig, Michael N Gould, Jill D Haag, Steven P Howard, Robert G Thorne. Intranasal administration of the chemotherapeutic perillyl alcohol results in selective delivery to the cerebrospinal fluid in rats. Scientific reports. 2021 03; 11(1):6351. doi: 10.1038/s41598-021-85293-4. [PMID: 33737566]
  • Chao Sun, Xianjuan Dong, Rubing Zhang, Congxia Xie. Effectiveness of recombinant Escherichia coli on the production of (R)-(+)-perillyl alcohol. BMC biotechnology. 2021 01; 21(1):3. doi: 10.1186/s12896-020-00662-7. [PMID: 33419424]
  • Soodeh Rajabi, Hamid Najafipour, Saeideh Jafarinejad Farsangi, Siyavash Joukar, Ahmad Beik, Maryam Iranpour, Zeinab Kordestani. Perillyle alcohol and Quercetin ameliorate monocrotaline-induced pulmonary artery hypertension in rats through PARP1-mediated miR-204 down-regulation and its downstream pathway. BMC complementary medicine and therapies. 2020 Jul; 20(1):218. doi: 10.1186/s12906-020-03015-1. [PMID: 32660602]
  • Daniela Carneiro de Lima, Silvana Vianna Rodrigues, Gilson Teles Boaventura, Hee-Yeon Cho, Thomas C Chen, Axel H Schönthal, Clovis Orlando Da Fonseca. Simultaneous measurement of perillyl alcohol and its metabolite perillic acid in plasma and lung after inhalational administration in Wistar rats. Drug testing and analysis. 2020 Feb; 12(2):268-279. doi: 10.1002/dta.2722. [PMID: 31800149]
  • Zeeshan Fatima, Saif Hameed. Lipidomic Insight of Anticandidal Perillyl Alcohol and Sesamol Induced Candida Membrane Disruption: Implications of Lipid Alteration, Impaired Fluidity and Flippase Activity. Infectious disorders drug targets. 2020; 20(6):784-797. doi: 10.2174/1871526519666191023125020. [PMID: 31657691]
  • Monika Kopečná, Miloslav Macháček, Anna Nováčková, Georgios Paraskevopoulos, Jaroslav Roh, Kateřina Vávrová. Esters of terpene alcohols as highly potent, reversible, and low toxic skin penetration enhancers. Scientific reports. 2019 10; 9(1):14617. doi: 10.1038/s41598-019-51226-5. [PMID: 31601936]
  • Navneet Kaur, Khushminder Kaur Chahal, Amit Kumar, Ravinder Singh, Urvashi Bhardwaj. Antioxidant activity of Anethum graveolens L. essential oil constituents and their chemical analogues. Journal of food biochemistry. 2019 04; 43(4):e12782. doi: 10.1111/jfbc.12782. [PMID: 31353585]
  • Adriana A Marin Rodriguez, Leonardo J M Carvalho, Emilia A Kimura, Alejandro M Katzin. Perillyl alcohol exhibits in vitro inhibitory activity against Plasmodium falciparum and protects against experimental cerebral malaria. International journal of antimicrobial agents. 2018 Mar; 51(3):370-377. doi: 10.1016/j.ijantimicag.2017.08.025. [PMID: 28843818]
  • Malgorzata Miastkowska, Monika Konieczna, Elwira Lason, Malgorzata Tabaszewska, Elzbieta Sikora, Jan Ogonowski. The Release of Perillyl Alcohol from the Different Kind of Vehicles. Current pharmaceutical biotechnology. 2018; 19(7):573-580. doi: 10.2174/1389201019666180730165330. [PMID: 30062959]
  • Yixiao Xu, Wantie Wang, Keke Jin, Qifan Zhu, Hongzhou Lin, Minye Xie, Dexuan Wang. Perillyl alcohol protects human renal tubular epithelial cells from hypoxia/reoxygenation injury via inhibition of ROS, endoplasmic reticulum stress and activation of PI3K/Akt/eNOS pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Nov; 95(?):662-669. doi: 10.1016/j.biopha.2017.08.129. [PMID: 28886525]
  • Aline C Gomes, Angélica L Mello, Manuel G Ribeiro, Diogo G Garcia, Clovis O Da Fonseca, Marcela D'Alincourt Salazar, Axel H Schönthal, Thereza Quirico-Santos. Perillyl alcohol, a pleiotropic natural compound suitable for brain tumor therapy, targets free radicals. Archivum immunologiae et therapiae experimentalis. 2017 Aug; 65(4):285-297. doi: 10.1007/s00005-017-0459-5. [PMID: 28314870]
  • Lukas Schmidt, Thomas Göen. R-Limonene metabolism in humans and metabolite kinetics after oral administration. Archives of toxicology. 2017 Mar; 91(3):1175-1185. doi: 10.1007/s00204-016-1751-6. [PMID: 27325307]
  • Luciana Nalone Andrade, Ricardo Guimarães Amaral, Grace Anne Azevedo Dória, Cecília Santos Fonseca, Tayane Kayane Mariano da Silva, Ricardo Luiz Cavalcante Albuquerque Júnior, Sara Maria Thomazzi, Lázaro Gomes do Nascimento, Adriana Andrade Carvalho, Damião Pergentino de Sousa. In Vivo Anti-Tumor Activity and Toxicological Evaluations of Perillaldehyde 8,9-Epoxide, a Derivative of Perillyl Alcohol. International journal of molecular sciences. 2016 Jan; 17(1):. doi: 10.3390/ijms17010032. [PMID: 26742032]
  • Moiz A Ansari, Zeeshan Fatima, Saif Hameed. Anticandidal Effect and Mechanisms of Monoterpenoid, Perillyl Alcohol against Candida albicans. PloS one. 2016; 11(9):e0162465. doi: 10.1371/journal.pone.0162465. [PMID: 27627759]
  • Rizwana Tabassum, Kumar Vaibhav, Pallavi Shrivastava, Andleeb Khan, Mohd Ejaz Ahmed, Mohammad Ashafaq, M Badruzzaman Khan, Farah Islam, Mohammed M Safhi, Fakhrul Islam. Perillyl alcohol improves functional and histological outcomes against ischemia-reperfusion injury by attenuation of oxidative stress and repression of COX-2, NOS-2 and NF-κB in middle cerebral artery occlusion rats. European journal of pharmacology. 2015 Jan; 747(?):190-9. doi: 10.1016/j.ejphar.2014.09.015. [PMID: 25240714]
  • Patrizia A d'Alessio, Massoud Mirshahi, Jean-Francois Bisson, Marie C Bene. Skin repair properties of d-Limonene and perillyl alcohol in murine models. Anti-inflammatory & anti-allergy agents in medicinal chemistry. 2014 Mar; 13(1):29-35. doi: 10.2174/18715230113126660021. [PMID: 24160248]
  • Tabetha Sundin, Dennis Peffley, Patricia Hentosh. eIF4E-Overexpression imparts perillyl alcohol and rapamycin-mediated regulation of telomerase reverse transcriptase. Experimental cell research. 2013 Aug; 319(13):2103-2112. doi: 10.1016/j.yexcr.2013.05.029. [PMID: 23747720]
  • M M Silva, C O Da Fonseca, R Moura-Neto, J F Carvalho, T Quirico-Santos, M G Carvalho. Influence of GSTM1 and GSTT1 polymorphisms on the survival rate of patients with malignant glioma under perillyl alcohol-based therapy. Genetics and molecular research : GMR. 2013 May; 12(2):1621-30. doi: 10.4238/2013.may.14.2. [PMID: 23765968]
  • Florence Lefranc, Zhanjie Xu, Patricia Burth, Véronique Mathieu, Germain Revelant, Mauro Velho de Castro Faria, Caroline Noyon, Diogo Gomes Garcia, Damien Dufour, Céline Bruyère, Cassiano Felippe Gonçalves-de-Albuquerque, Pierre Van Antwerpen, Bernard Rogister, Stéphanie Hesse, Gilbert Kirsch, Robert Kiss. 4-Bromo-2-(piperidin-1-yl)thiazol-5-yl-phenyl methanone (12b) inhibits Na+/K(+)-ATPase and Ras oncogene activity in cancer cells. European journal of medicinal chemistry. 2013 May; 63(?):213-23. doi: 10.1016/j.ejmech.2013.01.046. [PMID: 23474907]
  • Francisco das Chagas Abreu da Silveira, Bruno de Almeida Lopes, Clovis Orlando da Fonseca, Thereza Quirico-Santos, Izabel Christina Nunes de Palmer Paixão, Lidia Maria da Fonte de Amorim. Analysis of EGF+61A>G polymorphism and EGF serum levels in Brazilian glioma patients treated with perillyl alcohol-based therapy. Journal of cancer research and clinical oncology. 2012 Aug; 138(8):1347-54. doi: 10.1007/s00432-012-1203-5. [PMID: 22481252]
  • Lars Duelund, Arnaud Amiot, Alexandra Fillon, Ole G Mouritsen. Influence of the active compounds of Perilla frutescens leaves on lipid membranes. Journal of natural products. 2012 Feb; 75(2):160-6. doi: 10.1021/np200713q. [PMID: 22272932]
  • Sabita N Saldanha, Trygve O Tollefsbol. The role of nutraceuticals in chemoprevention and chemotherapy and their clinical outcomes. Journal of oncology. 2012; 2012(?):192464. doi: 10.1155/2012/192464. [PMID: 22187555]
  • Abdul Quaiyoom Khan, Sana Nafees, Sarwat Sultana. Perillyl alcohol protects against ethanol induced acute liver injury in Wistar rats by inhibiting oxidative stress, NFκ-B activation and proinflammatory cytokine production. Toxicology. 2011 Jan; 279(1-3):108-14. doi: 10.1016/j.tox.2010.09.017. [PMID: 20923693]
  • Ompal Singh, Zakia Khanam, Neelam Misra, Manoj Kumar Srivastava. Chamomile (Matricaria chamomilla L.): An overview. Pharmacognosy reviews. 2011 Jan; 5(9):82-95. doi: 10.4103/0973-7847.79103. [PMID: 22096322]
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