bruneomycin (BioDeep_00001868225)
Main id: BioDeep_00000004839
代谢物信息卡片
streptonigrin
化学式: C25H22N4O8 (506.1437572)
中文名称: 棕霉素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C(=C(N=C1C(=O)O)C2=NC3=C(C=C2)C(=O)C(=C(C3=O)N)OC)N)C4=C(C(=C(C=C4)OC)OC)O
InChI: InChI=1S/C25H22N4O8/c1-9-14(10-6-8-13(35-2)23(36-3)20(10)30)15(26)19(29-17(9)25(33)34)12-7-5-11-18(28-12)22(32)16(27)24(37-4)21(11)31/h5-8,30H,26-27H2,1-4H3,(H,33,34)
描述信息
Complex cytotoxic antibiotic obtained from Streptomyces flocculus or S. rufochronmogenus. It is used in advanced carcinoma and causes leukopenia.
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C259 - Antineoplastic Antibiotic
D000970 - Antineoplastic Agents
同义名列表
2 个代谢物同义名
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:9287
- KEGG: C02081
- KEGGdrug: D05931
- PubChem: 5298
- ChEMBL: CHEMBL11417
- MeSH: Streptonigrin
- CAS: 1079893-79-0
- CAS: 3930-19-6
- MetaboLights: MTBLC9287
- PubChem: 5167
- KNApSAcK: C00026485
- NIKKAJI: J2.203I
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Huiqiang Wei, Jianghong Guo, Xiao Sun, Wenfeng Gou, Hongxin Ning, Haihua Shang, Qiang Liu, Wenbin Hou, Yiliang Li. Discovery of Natural Ursane-type SENP1 Inhibitors and the Platinum Resistance Reversal Activity Against Human Ovarian Cancer Cells: A Structure-Activity Relationship Study.
Journal of natural products.
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European journal of medicinal chemistry.
2021 Dec; 226(?):113840. doi:
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Cells.
2021 01; 10(1):. doi:
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Oncology research and treatment.
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Der Urologe. Ausg. A.
2012 Nov; 51(11):1562-71. doi:
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Annals of family medicine.
2010 Jan; 8(1):11-8. doi:
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Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2007 Mar; 23(3):142-5. doi:
10.1080/09513590701214463. [PMID: 17454167] - Sujatha Subramoni, Ramesh V Sonti. Growth deficiency of a Xanthomonas oryzae pv. oryzae fur mutant in rice leaves is rescued by ascorbic acid supplementation.
Molecular plant-microbe interactions : MPMI.
2005 Jul; 18(7):644-51. doi:
10.1094/mpmi-18-0644. [PMID: 16042010] - Claudio Viegas, Vanderlan da S Bolzani, Maysa Furlan, Eliezer J Barreiro, Maria Claudia M Young, Daniela Tomazela, Marcos N Eberlin. Further bioactive piperidine alkaloids from the flowers and green fruits of Cassia spectabilis.
Journal of natural products.
2004 May; 67(5):908-10. doi:
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Journal of natural products.
2002 Jun; 65(6):932-4. doi:
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Molecular microbiology.
1998 Jun; 28(5):961-70. doi:
10.1046/j.1365-2958.1998.00852.x. [PMID: 9663682] - G G Harrigan, A A Gunatilaka, D G Kingston, G W Chan, R K Johnson. Isolation of bioactive and other oxoaporphine alkaloids from two annonaceous plants, Xylopia aethiopica and Miliusa cf. banacea.
Journal of natural products.
1994 Jan; 57(1):68-73. doi:
10.1021/np50103a009. [PMID: 8158166] - Y P Liu, J B Wu. [Preparation and biological activities of monoclonal antibody-streptonigrin immunoconjugates].
Yao xue xue bao = Acta pharmaceutica Sinica.
1992; 27(7):498-502. doi:
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Microbial pathogenesis.
1987 Nov; 3(5):351-63. doi:
10.1016/0882-4010(87)90005-2. [PMID: 3143887] - P H Williams, N H Carbonetti. Iron, siderophores, and the pursuit of virulence: independence of the aerobactin and enterochelin iron uptake systems in Escherichia coli.
Infection and immunity.
1986 Mar; 51(3):942-7. doi:
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Cancer chemotherapy reports. Part 2.
1974 Dec; 4(4):11-7. doi:
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1972 Jun; 71(1):35-52. doi:
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1966 Oct; 92(4):967-71. doi:
10.1128/jb.92.4.967-971.1966. [PMID: 4288803] - N S Mizuno. Distribution of tritiated methyl ester of streptonigrin in mice bearing sarcoma 180.
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1966 Mar; 15(3):394-5. doi:
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