3-Methyladenine (BioDeep_00000001843)

 

Secondary id: BioDeep_00000400011

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


3-Methyl-3H-purin-6-ylamine (acd/name 4.0)

化学式: C6H7N5 (149.0701)
中文名称: 3-甲基腺嘌呤, 6-氨基-3-甲基嘌呤
谱图信息: 最多检出来源 Homo sapiens(blood) 36.14%

分子结构信息

SMILES: CN(C=1)C(=N2)C(N=C2)=C(N)N1
InChI: InChI=1/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3H,7H2,1H3

描述信息

3-Methyladenine, also known as 3-ma nucleobase, belongs to the class of organic compounds known as 6-aminopurines. These are purines that carry an amino group at position 6. Purine is a bicyclic aromatic compound made up of a pyrimidine ring fused to an imidazole ring. 3-Methyladenine exists in all living species, ranging from bacteria to humans. 3-Methyladenine has been detected, but not quantified, in several different foods, such as soft-necked garlics, chinese bayberries, burbots, amaranths, and tea. This could make 3-methyladenine a potential biomarker for the consumption of these foods. 3-Methyladenine is one of the purines damaged by alkylation and oxidation which can be recognized and excised by the human 3-methyladenine DNA glycosylase (AAG) (EC: EC3.2.2.21).
3-Methyladenine is one of the purines damaged by alkylation and oxidation which can be recognized and excised by the human 3-methyladenine DNA glycosylase (AAG) (EC: EC 3.2.2.21) [HMDB]. 3-Methyladenine is found in many foods, some of which are sacred lotus, evergreen huckleberry, swamp cabbage, and red rice.
Acquisition and generation of the data is financially supported in part by CREST/JST.
KEIO_ID M030

同义名列表

13 个代谢物同义名

3-Methyl-3H-purin-6-ylamine (acd/name 4.0); 3-Methyl-3H-purin-6-amine (acd/name 4.0); 3-METHYL-3H-purin-6-ylamine; 3-Methyl-3H-purin-6-amine; 6-Amino-3-methylpurine; 3-Methyl-3H-adenine; N(3)-Methyladenine; 3-Methyl-adenine; 3-MA nucleobase; 3-methyladenine; 3-Methyladenine; 3-Methyladenine; 3-Methyladenine



数据库引用编号

33 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(1)

BioCyc(0)

PlantCyc(0)

代谢反应

65 个相关的代谢反应过程信息。

Reactome(65)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

6 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 15 AKT1, ANXA5, ATG5, BCL2, BECN1, CASP3, MAP1A, MTOR, PIK3C3, PIK3CA, PIK3R6, SQSTM1, SYT1, TLR4, TP53
Golgi apparatus, trans-Golgi network membrane 1 BECN1
Peripheral membrane protein 5 ANXA5, ATG5, BECN1, MTOR, PIK3R6
Endosome membrane 2 BECN1, TLR4
Endoplasmic reticulum membrane 3 BCL2, BECN1, MTOR
Mitochondrion membrane 1 BECN1
Cytoplasmic vesicle, autophagosome 3 BECN1, PIK3C3, SQSTM1
Nucleus 8 AKT1, BCL2, BECN1, CASP3, MTOR, PARP1, SQSTM1, TP53
autophagosome 5 ATG5, BECN1, MAP1LC3A, PIK3C3, SQSTM1
cytosol 15 AKT1, ANXA5, ATG5, BCL2, BECN1, CASP3, MAP1A, MAP1LC3A, MTOR, PARP1, PIK3C3, PIK3CA, PIK3R6, SQSTM1, TP53
dendrite 3 BECN1, MAP1A, MTOR
mitochondrial membrane 1 BECN1
nuclear body 2 BECN1, PARP1
phagocytic vesicle 2 BECN1, MTOR
phosphatidylinositol 3-kinase complex, class III 2 BECN1, PIK3C3
trans-Golgi network 1 BECN1
centrosome 1 TP53
nucleoplasm 6 AKT1, CASP3, MTOR, PARP1, SQSTM1, TP53
Cell membrane 4 AKT1, PIK3R6, TLR4, TNF
Lipid-anchor 1 MAP1LC3A
Cytoplasmic side 1 MTOR
lamellipodium 2 AKT1, PIK3CA
Golgi apparatus membrane 1 MTOR
Synapse 2 MAP1A, SYT1
cell cortex 1 AKT1
cell surface 2 TLR4, TNF
dendritic shaft 1 MAP1A
glutamatergic synapse 7 AKT1, ATG5, CASP3, MAP1LC3A, PIK3C3, SQSTM1, SYT1
Golgi apparatus 1 SYT1
Golgi membrane 1 MTOR
lysosomal membrane 1 MTOR
neuronal cell body 3 CASP3, MAP1A, TNF
postsynapse 2 AKT1, ATG5
presynaptic membrane 1 SYT1
sarcolemma 1 ANXA5
synaptic vesicle 1 SYT1
Cytoplasm, cytosol 2 PARP1, SQSTM1
Lysosome 2 MTOR, SQSTM1
endosome 2 BECN1, PIK3C3
plasma membrane 6 AKT1, PIK3CA, PIK3R6, SYT1, TLR4, TNF
presynaptic active zone 1 SYT1
synaptic vesicle membrane 1 SYT1
Membrane 11 AKT1, ANXA5, ATG5, BCL2, MTOR, PARP1, PIK3C3, PIK3R6, SYT1, TLR4, TP53
axon 3 ATG5, MAP1A, SYT1
extracellular exosome 2 ANXA5, SQSTM1
Lysosome membrane 1 MTOR
endoplasmic reticulum 4 BCL2, BECN1, SQSTM1, TP53
extracellular space 3 IL10, IL6, TNF
perinuclear region of cytoplasm 2 PIK3CA, TLR4
Schaffer collateral - CA1 synapse 1 ATG5
intercalated disc 1 PIK3CA
mitochondrion 4 BCL2, PARP1, SQSTM1, TP53
protein-containing complex 5 AKT1, ATG5, BCL2, PARP1, TP53
intracellular membrane-bounded organelle 2 MAP1LC3A, SQSTM1
Microsome membrane 1 MTOR
postsynaptic density 2 CASP3, SYT1
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 TLR4
Secreted 2 IL10, IL6
extracellular region 4 ANXA5, IL10, IL6, TNF
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 2 BCL2, SYT1
mitochondrial outer membrane 2 BCL2, MTOR
excitatory synapse 1 SYT1
hippocampal mossy fiber to CA3 synapse 1 SYT1
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
transcription regulator complex 2 PARP1, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 SYT1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 3 ANXA5, TLR4, TNF
cytoplasmic vesicle 1 SQSTM1
microtubule cytoskeleton 1 AKT1
nucleolus 2 PARP1, TP53
axon cytoplasm 1 MAP1A
midbody 1 PIK3C3
P-body 1 SQSTM1
Early endosome 1 TLR4
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
postsynaptic membrane 1 SYT1
Membrane raft 1 TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 3 MAP1A, MAP1LC3A, TP53
focal adhesion 1 ANXA5
microtubule 2 MAP1A, MAP1LC3A
spindle 1 AKT1
GABA-ergic synapse 1 PIK3C3
Peroxisome 1 PIK3C3
Nucleus, PML body 3 MTOR, SQSTM1, TP53
PML body 3 MTOR, SQSTM1, TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 ANXA5
axoneme 2 ATG5, PIK3C3
Cell projection, ruffle 1 TLR4
Cytoplasm, myofibril, sarcomere 1 SQSTM1
Late endosome 3 MAP1LC3A, PIK3C3, SQSTM1
ruffle 1 TLR4
sarcomere 1 SQSTM1
receptor complex 1 TLR4
Zymogen granule membrane 1 ANXA5
neuron projection 2 MAP1A, SYT1
ciliary basal body 1 AKT1
chromatin 2 PARP1, TP53
microtubule associated complex 1 MAP1A
Cytoplasmic vesicle, autophagosome membrane 1 MAP1LC3A
autophagosome membrane 1 MAP1LC3A
phagocytic cup 2 TLR4, TNF
phagocytic vesicle membrane 2 ATG5, PIK3C3
Chromosome 1 PARP1
Nucleus, nucleolus 1 PARP1
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
sperm midpiece 1 SQSTM1
organelle membrane 1 MAP1LC3A
site of double-strand break 2 PARP1, TP53
nuclear envelope 2 MTOR, PARP1
Endomembrane system 3 MAP1LC3A, MTOR, SYT1
phagophore assembly site 3 BECN1, PIK3C3, SQSTM1
phosphatidylinositol 3-kinase complex, class III, type I 2 BECN1, PIK3C3
phosphatidylinositol 3-kinase complex, class III, type II 2 BECN1, PIK3C3
Preautophagosomal structure membrane 1 ATG5
Atg12-Atg5-Atg16 complex 1 ATG5
mitochondria-associated endoplasmic reticulum membrane contact site 1 ATG5
phagophore assembly site membrane 1 ATG5
axon initial segment 1 MAP1A
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
exocytic vesicle 1 SYT1
lipopolysaccharide receptor complex 1 TLR4
endoplasmic reticulum lumen 1 IL6
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
phosphatidylinositol 3-kinase complex 2 PIK3CA, PIK3R6
phosphatidylinositol 3-kinase complex, class IA 2 PIK3CA, PIK3R6
dense core granule 1 SYT1
presynaptic endosome 1 PIK3C3
aggresome 1 SQSTM1
vesicle membrane 1 ANXA5
clathrin-coated endocytic vesicle membrane 1 SYT1
[Isoform 1]: Nucleus 1 TP53
protein-DNA complex 1 PARP1
death-inducing signaling complex 1 CASP3
intracellular non-membrane-bounded organelle 1 SQSTM1
Cytoplasmic vesicle, secretory vesicle membrane 1 SYT1
Lewy body 1 SQSTM1
postsynaptic cytosol 1 SYT1
Cytoplasmic vesicle, phagosome 1 MTOR
Preautophagosomal structure 1 SQSTM1
site of DNA damage 1 PARP1
presynaptic cytosol 1 SYT1
transferase complex 1 ATG5
postsynaptic endosome 1 PIK3C3
dendritic microtubule 1 MAP1A
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
Autolysosome 3 MAP1LC3A, PIK3C3, SQSTM1
inclusion body 1 SQSTM1
interleukin-6 receptor complex 1 IL6
neuron projection terminus 1 SYT1
endothelial microparticle 1 ANXA5
Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane 1 SYT1
chromaffin granule membrane 1 SYT1
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
dendritic branch 1 MAP1A
primary dendrite 1 MAP1A
clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane 1 SYT1
clathrin-sculpted acetylcholine transport vesicle membrane 1 SYT1
clathrin-sculpted glutamate transport vesicle membrane 1 SYT1
clathrin-sculpted monoamine transport vesicle membrane 1 SYT1
cytoplasmic side of mitochondrial outer membrane 1 BECN1
phosphatidylinositol 3-kinase complex, class IB 2 PIK3CA, PIK3R6
amphisome 1 SQSTM1
[Beclin-1-C 35 kDa]: Mitochondrion 1 BECN1
[Beclin-1-C 37 kDa]: Mitochondrion 1 BECN1
phagophore 1 ATG5
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Kun Wang, Jiatong Tang, Shengxian Fan, Haochen Su, Ranran Yu, Yixuan Zhang, Hao Wu, Ying Lv, Shu Zhang, Xiaoping Zou. ABBV-744 induces autophagy in gastric cancer cells by regulating PI3K/AKT/mTOR/p70S6k and MAPK signaling pathways. Neoplasia (New York, N.Y.). 2023 11; 45(?):100936. doi: 10.1016/j.neo.2023.100936. [PMID: 37769529]
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