3-Methyladenine (BioDeep_00000001843)

 

Secondary id: BioDeep_00000400011

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019 Volatile Flavor Compounds


代谢物信息卡片


3-Methyl-3H-purin-6-ylamine (acd/name 4.0)

化学式: C6H7N5 (149.07014220000002)
中文名称: 3-甲基腺嘌呤, 6-氨基-3-甲基嘌呤
谱图信息: 最多检出来源 Homo sapiens(blood) 0.34%

分子结构信息

SMILES: CN(C=1)C(=N2)C(N=C2)=C(N)N1
InChI: InChI=1/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3H,7H2,1H3

描述信息

3-Methyladenine, also known as 3-ma nucleobase, belongs to the class of organic compounds known as 6-aminopurines. These are purines that carry an amino group at position 6. Purine is a bicyclic aromatic compound made up of a pyrimidine ring fused to an imidazole ring. 3-Methyladenine exists in all living species, ranging from bacteria to humans. 3-Methyladenine has been detected, but not quantified, in several different foods, such as soft-necked garlics, chinese bayberries, burbots, amaranths, and tea. This could make 3-methyladenine a potential biomarker for the consumption of these foods. 3-Methyladenine is one of the purines damaged by alkylation and oxidation which can be recognized and excised by the human 3-methyladenine DNA glycosylase (AAG) (EC: EC3.2.2.21).
3-Methyladenine is one of the purines damaged by alkylation and oxidation which can be recognized and excised by the human 3-methyladenine DNA glycosylase (AAG) (EC: EC 3.2.2.21) [HMDB]. 3-Methyladenine is found in many foods, some of which are sacred lotus, evergreen huckleberry, swamp cabbage, and red rice.
Acquisition and generation of the data is financially supported in part by CREST/JST.
KEIO_ID M030

同义名列表

13 个代谢物同义名

3-Methyl-3H-purin-6-ylamine (acd/name 4.0); 3-Methyl-3H-purin-6-amine (acd/name 4.0); 3-METHYL-3H-purin-6-ylamine; 3-Methyl-3H-purin-6-amine; 6-Amino-3-methylpurine; 3-Methyl-3H-adenine; N(3)-Methyladenine; 3-Methyl-adenine; 3-MA nucleobase; 3-methyladenine; 3-Methyladenine; 3-Methyladenine; 3-Methyladenine



数据库引用编号

33 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(1)

BioCyc(0)

PlantCyc(0)

代谢反应

65 个相关的代谢反应过程信息。

Reactome(65)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

6 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kun Wang, Jiatong Tang, Shengxian Fan, Haochen Su, Ranran Yu, Yixuan Zhang, Hao Wu, Ying Lv, Shu Zhang, Xiaoping Zou. ABBV-744 induces autophagy in gastric cancer cells by regulating PI3K/AKT/mTOR/p70S6k and MAPK signaling pathways. Neoplasia (New York, N.Y.). 2023 11; 45(?):100936. doi: 10.1016/j.neo.2023.100936. [PMID: 37769529]
  • Lihua Cui, Caixia Li, Guixian Zhang, Lanqiu Zhang, Guowang Yao, Yuzhen Zhuo, Naiqiang Cui, Shukun Zhang. S1P/S1PR2 promote pancreatic stellate cell activation and pancreatic fibrosis in chronic pancreatitis by regulating autophagy and the NLRP3 inflammasome. Chemico-biological interactions. 2023 May; 380(?):110541. doi: 10.1016/j.cbi.2023.110541. [PMID: 37169277]
  • Yuting Wu, Cheng Huang, Tianlu Shi, Jun Li. Deficiency of NLR family member NLRC5 alleviates alcohol induced hepatic injury and steatosis by enhancing autophagy of hepatocytes. Toxicology and applied pharmacology. 2023 Feb; 461(?):116406. doi: 10.1016/j.taap.2023.116406. [PMID: 36708882]
  • Ting Li, Jie Zhao, Shuying Miao, Yiyang Chen, Yunfei Xu, Ying Liu. Protective effect of H2S on LPS‑induced AKI by promoting autophagy. Molecular medicine reports. 2022 03; 25(3):. doi: 10.3892/mmr.2022.12612. [PMID: 35059738]
  • Yujie Zhong, Dianjun Sun, Yanpeng Yao, Qi Liu, Tianmin Guo, Xin Wang, Xiaoli Peng. Autophagy and mitochondrial dynamics contribute to the protective effect of diosgenin against 3-MCPD induced kidney injury. Chemico-biological interactions. 2022 Mar; 355(?):109850. doi: 10.1016/j.cbi.2022.109850. [PMID: 35149085]
  • Ibrahim Morgan, Ludger A Wessjohann, Goran N Kaluđerović. In Vitro Anticancer Screening and Preliminary Mechanistic Study of A-Ring Substituted Anthraquinone Derivatives. Cells. 2022 01; 11(1):. doi: 10.3390/cells11010168. [PMID: 35011730]
  • Nan Yang, Yunxiao Shang. Ferrostatin-1 and 3-Methyladenine Ameliorate Ferroptosis in OVA-Induced Asthma Model and in IL-13-Challenged BEAS-2B Cells. Oxidative medicine and cellular longevity. 2022; 2022(?):9657933. doi: 10.1155/2022/9657933. [PMID: 35154576]
  • Jieyu Yue, Yingjie Wang, Jinlan Jiao, Huazhong Wang. Comparative transcriptomic and metabolic profiling provides insight into the mechanism by which the autophagy inhibitor 3-MA enhances salt stress sensitivity in wheat seedlings. BMC plant biology. 2021 Dec; 21(1):577. doi: 10.1186/s12870-021-03351-5. [PMID: 34872497]
  • Yongteng Zhao, Jing Cui, Qingqing Li, Tengsheng Qiao, Du-Bo Zhong, Peng Zhao, Xuya Yu. A joint strategy comprising melatonin and 3-methyladenine to concurrently stimulate biomass and astaxanthin hyperaccumulation by Haematococcus pluvialis. Bioresource technology. 2021 Dec; 341(?):125784. doi: 10.1016/j.biortech.2021.125784. [PMID: 34419876]
  • Junping Guo, Wei Chen, Beibei Bao, Dayong Zhang, Jianping Pan, Mao Zhang. Protective effect of berberine against LPS-induced endothelial cell injury via the JNK signaling pathway and autophagic mechanisms. Bioengineered. 2021 12; 12(1):1324-1337. doi: 10.1080/21655979.2021.1915671. [PMID: 33896366]
  • Jinghui Zhai, Huan Gao, Shuo Wang, Sixi Zhang, Xiaoyu Qu, Yueming Zhang, Lina Tao, Jingmeng Sun, Yanqing Song, Li Fu. Ginsenoside Rg3 attenuates cisplatin-induced kidney injury through inhibition of apoptosis and autophagy-inhibited NLRP3. Journal of biochemical and molecular toxicology. 2021 Nov; 35(11):e22896. doi: 10.1002/jbt.22896. [PMID: 34423507]
  • Myriam Mireault, Yong Xiao, Benoît Barbeau, Catherine Jumarie. Cadmium affects autophagy in the human intestinal cells Caco-2 through ROS-mediated ERK activation. Cell biology and toxicology. 2021 Sep; ?(?):. doi: 10.1007/s10565-021-09655-4. [PMID: 34580807]
  • Jiarui Zhao, Bo Hu, Han Xiao, Qiong Yang, Qi Cao, Xia Li, Qian Zhang, Aiguo Ji, Shuliang Song. Fucoidan reduces lipid accumulation by promoting foam cell autophagy via TFEB. Carbohydrate polymers. 2021 Sep; 268(?):118247. doi: 10.1016/j.carbpol.2021.118247. [PMID: 34127226]
  • Liang Pei, Linxi He. Hepatoprotective effect of anemoside B4 against sepsis-induced acute liver injury through modulating the mTOR/p70S6K-mediated autophagy. Chemico-biological interactions. 2021 Aug; 345(?):109534. doi: 10.1016/j.cbi.2021.109534. [PMID: 34051206]
  • Di Liu, Wan-Pin Sun, Jing-Wei Chen, Yan Jiang, Rong Xue, Lin-Hui Wang, Koji Murao, Guo-Xing Zhang. Autophagy contributes to angiotensin II induced dysfunction of HUVECs. Clinical and experimental hypertension (New York, N.Y. : 1993). 2021 Jul; 43(5):462-473. doi: 10.1080/10641963.2021.1901110. [PMID: 33775188]
  • Alberto Ruiz Priego, Emilio González Parra, Sebastián Mas, José Luis Morgado-Pascual, Marta Ruiz-Ortega, Sandra Rayego-Mateos. Bisphenol A Modulates Autophagy and Exacerbates Chronic Kidney Damage in Mice. International journal of molecular sciences. 2021 Jul; 22(13):. doi: 10.3390/ijms22137189. [PMID: 34281243]
  • Rong Tang, Liu Jia, Yunlong Li, Junbo Zheng, Pingping Qi. Narciclasine attenuates sepsis-induced myocardial injury by modulating autophagy. Aging. 2021 05; 13(11):15151-15163. doi: 10.18632/aging.203078. [PMID: 34035183]
  • Hsin-Ling Yang, Hui-Wen Liu, Sirjana Shrestha, Varadharajan Thiyagarajan, Hui-Chi Huang, You-Cheng Hseu. Antrodia salmonea induces apoptosis and enhances cytoprotective autophagy in colon cancer cells. Aging. 2021 05; 13(12):15964-15989. doi: 10.18632/aging.203019. [PMID: 34031264]
  • Jin Wang, Dan Li, Zhinan Zhang, Yan Zhang, Zhandong Lei, Wenwen Jin, Jimin Cao, Xiangying Jiao. Autoantibody against angiotensin II type I receptor induces pancreatic β-cell apoptosis via enhancing autophagy. Acta biochimica et biophysica Sinica. 2021 May; 53(6):784-795. doi: 10.1093/abbs/gmab049. [PMID: 33928341]
  • Ying Liu, Jiawei Xu, Tian Liu, Jinxiang Wu, Jiping Zhao, Junfei Wang, Minfang Zou, Lili Cao, Xiaofei Liu, Yun Pan, Siyuan Huang, Liang Dong. FSTL1 aggravates cigarette smoke-induced airway inflammation and airway remodeling by regulating autophagy. BMC pulmonary medicine. 2021 Jan; 21(1):45. doi: 10.1186/s12890-021-01409-6. [PMID: 33509151]
  • Xiang Liu, Chunyan Yang, Ying Deng, Ping Liu, Hongqiu Yang, Xiaoshuang Du, Yu Du. Polygoni Multiflori Radix Preparat Delays Skin Aging by Inducing Mitophagy. BioMed research international. 2021; 2021(?):5847153. doi: 10.1155/2021/5847153. [PMID: 33511202]
  • Zixuan Liu, Xuying Lv, Erqun Song, Yang Song. Fostered Nrf2 expression antagonizes iron overload and glutathione depletion to promote resistance of neuron-like cells to ferroptosis. Toxicology and applied pharmacology. 2020 11; 407(?):115241. doi: 10.1016/j.taap.2020.115241. [PMID: 32937103]
  • Yaomin Wang, Chen Xia, Lianfu Chen, Yi Charlie Chen, Youying Tu. Saponins Extracted from Tea (Camellia Sinensis) Flowers Induces Autophagy in Ovarian Cancer Cells. Molecules (Basel, Switzerland). 2020 Nov; 25(22):. doi: 10.3390/molecules25225254. [PMID: 33187244]
  • Mikyoung You, Young-Hyun Lee, Hwa-Jin Kim, Ji Hyun Kook, Hyeon-A Kim. St. John's Wort Suppresses Growth in Triple-Negative Breast Cancer Cell Line MDA-MB-231 by Inducing Prodeath Autophagy and Apoptosis. Nutrients. 2020 Oct; 12(10):. doi: 10.3390/nu12103175. [PMID: 33080824]
  • Tongjian Zhao, Jie Ma, Lulu Li, Wenjing Teng, Yafei Tian, Yongjun Ma, Wei Wang, Weiqun Yan, Ping Jiao. MKP-5 Relieves Lipotoxicity-Induced Islet β-Cell Dysfunction and Apoptosis via Regulation of Autophagy. International journal of molecular sciences. 2020 Sep; 21(19):. doi: 10.3390/ijms21197161. [PMID: 32998359]
  • Juan-Ting Liu, Jaramar Balmori-Cedeno, Ehab Misk, John S Lumsden. Pharmacological and nutritional modulation of autophagy in a rainbow trout (Oncorhynchus mykiss) gill cell line, RTgill-W1. In vitro cellular & developmental biology. Animal. 2020 Sep; 56(8):659-669. doi: 10.1007/s11626-020-00490-1. [PMID: 32901427]
  • Xiaofang Tan, Huifeng Guan, Yang Yang, Shenying Luo, Lina Hou, Hongzhuan Chen, Juan Li. Cu(II) disrupts autophagy-mediated lysosomal degradation of oligomeric Aβ in microglia via mTOR-TFEB pathway. Toxicology and applied pharmacology. 2020 08; 401(?):115090. doi: 10.1016/j.taap.2020.115090. [PMID: 32512069]
  • Chun-Yu Liu, Min Wang, Hong-Min Yu, Fang-Xuan Han, Qiong-Shi Wu, Xing-Jun Cai, Hiroshi Kurihara, Yong-Xing Chen, Yi-Fang Li, Rong-Rong He. Ferroptosis is involved in alcohol-induced cell death in vivo and in vitro. Bioscience, biotechnology, and biochemistry. 2020 Aug; 84(8):1621-1628. doi: 10.1080/09168451.2020.1763155. [PMID: 32419644]
  • Chunxiao Li, Lu Chen, Min Song, Zhirui Fang, Lusha Zhang, Joel Wake Coffie, Liyuan Zhang, Lulu Ma, Qianyi Wang, Wenjie Yang, Leyu Fang, Shaoxia Wang, Xiumei Gao, Hong Wang. Ferulic acid protects cardiomyocytes from TNF-α/cycloheximide-induced apoptosis by regulating autophagy. Archives of pharmacal research. 2020 Aug; 43(8):863-874. doi: 10.1007/s12272-020-01252-z. [PMID: 32720163]
  • Carolina Hassibe Thomé, Germano Aguiar Ferreira, Diego Antonio Pereira-Martins, Guilherme Augusto Dos Santos, César Alexander Ortiz, Lucas Eduardo Botelho de Souza, Lays Martins Sobral, Cleide Lúcia Araújo Silva, Priscila Santos Scheucher, Cristiane Damas Gil, Andréia Machado Leopoldino, Douglas R A Silveira, Juan L Coelho-Silva, Fabíola Traina, Luisa C Koury, Raul A M Melo, Rosane Bittencourt, Katia Pagnano, Ricardo Pasquini, Elenaide C Nunes, Evandro M Fagundes, Ana Beatriz F Gloria, Fábio Rodrigues Kerbauy, Maria de Lourdes Chauffaille, Armand Keating, Martin S Tallman, Raul C Ribeiro, Richard Dillon, Arnold Ganser, Bob Löwenberg, Peter Valk, Francesco Lo-Coco, Miguel A Sanz, Nancy Berliner, Vitor Marcel Faça, Eduardo M Rego. NTAL is associated with treatment outcome, cell proliferation and differentiation in acute promyelocytic leukemia. Scientific reports. 2020 06; 10(1):10315. doi: 10.1038/s41598-020-66223-2. [PMID: 32587277]
  • Xinbo Zhang, Cristina M Ramírez, Binod Aryal, Julio Madrigal-Matute, Xinran Liu, Antonio Diaz, Marta Torrecilla-Parra, Yajaira Suárez, Ana M Cuervo, William C Sessa, Carlos Fernández-Hernando. Cav-1 (Caveolin-1) Deficiency Increases Autophagy in the Endothelium and Attenuates Vascular Inflammation and Atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology. 2020 06; 40(6):1510-1522. doi: 10.1161/atvbaha.120.314291. [PMID: 32349535]
  • Yi-Ju Chou, Ching-Cheng Lin, Ivan Dzhagalov, Nien-Jung Chen, Chao-Hsiung Lin, Chun-Cheng Lin, Szu-Ting Chen, Kuo-Hsin Chen, Shu-Ling Fu. Vaccine adjuvant activity of a TLR4-activating synthetic glycolipid by promoting autophagy. Scientific reports. 2020 05; 10(1):8422. doi: 10.1038/s41598-020-65422-1. [PMID: 32439945]
  • Yuqing Kang, Yuebing Li, Heng Wen, Junfeng Zhu, Jiangbo Zheng, Zhaoming Feng. Prevention of renal ischemia and reperfusion injury by penehyclidine hydrochloride through autophagy activation. Molecular medicine reports. 2020 05; 21(5):2182-2192. doi: 10.3892/mmr.2020.11024. [PMID: 32186764]
  • Lin Xiaolong, Guo Dongmin, Mihua Liu, Wang Zuo, Hu Huijun, Tan Qiufen, Hu XueMei, Lin Wensheng, Pan Yuping, Lin Jun, Zeng Zhaolin. FGF21 induces autophagy-mediated cholesterol efflux to inhibit atherogenesis via RACK1 up-regulation. Journal of cellular and molecular medicine. 2020 05; 24(9):4992-5006. doi: 10.1111/jcmm.15118. [PMID: 32227589]
  • Anmao Li, Xingxin Li, Xuanxin Chen, Chensi Zeng, Zuo Wang, Zhen Li, Jianbin Chen. NUPR1 Silencing Induces Autophagy-Mediated Apoptosis in Multiple Myeloma Cells Through the PI3K/AKT/mTOR Pathway. DNA and cell biology. 2020 Mar; 39(3):368-378. doi: 10.1089/dna.2019.5196. [PMID: 31971825]
  • Yuzheng Zhou, Qianqian Zhang, Yangyang Kong, Xiaohong Guo, Haiyan Zhang, Huiqin Fan, Lixin Liu. Insulin-Like Growth Factor Binding Protein-Related Protein 1 Activates Primary Hepatic Stellate Cells via Autophagy Regulated by the PI3K/Akt/mTOR Signaling Pathway. Digestive diseases and sciences. 2020 02; 65(2):509-523. doi: 10.1007/s10620-019-05798-x. [PMID: 31468266]
  • Di Zhao, Yan Gao, Wei Wang, Hui Pei, Chunxiao Xu, Zhuo Zhao. PKD deletion promotes autophagy and inhibits hypertrophy in cardiomyocyte. Experimental cell research. 2020 01; 386(2):111742. doi: 10.1016/j.yexcr.2019.111742. [PMID: 31759056]
  • Xinxu Zhang, Yuanyuan Deng, Juan Xiang, Huixia Liu, Jiani Zhang, Jie Liao, Ke Chen, Bo Liu, Jun Liu, Ying Pu. Galangin Improved Non-Alcoholic Fatty Liver Disease in Mice by Promoting Autophagy. Drug design, development and therapy. 2020; 14(?):3393-3405. doi: 10.2147/dddt.s258187. [PMID: 32884242]
  • Yufei Cheng, Xudong Pan, Jing Wang, Xu Li, Shaonan Yang, Ruihua Yin, Aijun Ma, Xiaoyan Zhu. Fucoidan Inhibits NLRP3 Inflammasome Activation by Enhancing p62/SQSTM1-Dependent Selective Autophagy to Alleviate Atherosclerosis. Oxidative medicine and cellular longevity. 2020; 2020(?):3186306. doi: 10.1155/2020/3186306. [PMID: 33505579]
  • David S Enyart, Chelsea L Crocker, Jennifer R Stansell, Madeleine Cutrone, Meghann M Dintino, Stephen T Kinsey, Stephan L Brown, Bradley L Baumgarner. Low-dose caffeine administration increases fatty acid utilization and mitochondrial turnover in C2C12 skeletal myotubes. Physiological reports. 2020 01; 8(1):e14340. doi: 10.14814/phy2.14340. [PMID: 31960608]
  • Peng Zhang, Yong Li, Yingjie Fu, Lei Huang, Bailin Liu, Lubo Zhang, Xuesi M Shao, Daliao Xiao. Inhibition of Autophagy Signaling via 3-methyladenine Rescued Nicotine-Mediated Cardiac Pathological Effects and Heart Dysfunctions. International journal of biological sciences. 2020; 16(8):1349-1362. doi: 10.7150/ijbs.41275. [PMID: 32210724]
  • Hui Cao, Qingling Jia, Li Yan, Chuan Chen, Sanli Xing, Dingzhu Shen. Quercetin Suppresses the Progression of Atherosclerosis by Regulating MST1-Mediated Autophagy in ox-LDL-Induced RAW264.7 Macrophage Foam Cells. International journal of molecular sciences. 2019 Dec; 20(23):. doi: 10.3390/ijms20236093. [PMID: 31816893]
  • Yong-Bo Li, De-Zhou Cui, Xin-Xia Sui, Chen Huang, Cheng-Yan Huang, Qing-Qi Fan, Xiu-Sheng Chu. Autophagic Survival Precedes Programmed Cell Death in Wheat Seedlings Exposed to Drought Stress. International journal of molecular sciences. 2019 Nov; 20(22):. doi: 10.3390/ijms20225777. [PMID: 31744172]
  • Mai Shi, Shuang Yang, Xinwang Zhu, Da Sun, Dan Sun, Xue Jiang, Congxiao Zhang, Lining Wang. The RAGE/STAT5/autophagy axis regulates senescence in mesangial cells. Cellular signalling. 2019 10; 62(?):109334. doi: 10.1016/j.cellsig.2019.05.019. [PMID: 31158467]
  • Xiaofei Liang, Chao Wang, Yan Sun, Wei Song, Jing Lin, Jiashan Li, Xiuru Guan. p62/mTOR/LXRα pathway inhibits cholesterol efflux mediated by ABCA1 and ABCG1 during autophagy blockage. Biochemical and biophysical research communications. 2019 07; 514(4):1093-1100. doi: 10.1016/j.bbrc.2019.04.134. [PMID: 31101336]
  • Sisi Liu, Yanyan Xing, Junbing Wang, Rui Pan, Guangming Li, Haijie Tang, Guiling Chen, Liang Yan, Luyan Guo, Mingliang Jiang, Zheng Gong, Liqing Lin, Jun Dong. The Dual Role of HIV-1 gp120 V3 Loop-Induced Autophagy in the Survival and Apoptosis of the Primary Rat Hippocampal Neurons. Neurochemical research. 2019 Jul; 44(7):1636-1652. doi: 10.1007/s11064-019-02788-3. [PMID: 31006091]
  • Barbara Bobrowska-Korczak, Paulina Gątarek, Angelina Rosiak, Joanna Giebułtowicz, Joanna Kałużna-Czaplińska. Reduced levels of modified nucleosides in the urine of autistic children. Preliminary studies. Analytical biochemistry. 2019 04; 571(?):62-67. doi: 10.1016/j.ab.2019.02.009. [PMID: 30771338]
  • Jui-Hu Shih, Chuang-Hsin Chiu, Kuo-Hsing Ma, Yuahn-Sieh Huang, Chyng-Yann Shiue, Ting-Yin Yeh, Li-Ting Kao, Yang-Yi Lin, I-Hsun Li. Autophagy inhibition plays a protective role against 3, 4-methylenedioxymethamphetamine (MDMA)-induced loss of serotonin transporters and depressive-like behaviors in rats. Pharmacological research. 2019 04; 142(?):283-293. doi: 10.1016/j.phrs.2019.02.026. [PMID: 30826457]
  • Li-Hua Cui, Cai-Xia Li, Yu-Zhen Zhuo, Lei Yang, Nai-Qiang Cui, Shu-Kun Zhang. Saikosaponin d ameliorates pancreatic fibrosis by inhibiting autophagy of pancreatic stellate cells via PI3K/Akt/mTOR pathway. Chemico-biological interactions. 2019 Feb; 300(?):18-26. doi: 10.1016/j.cbi.2019.01.005. [PMID: 30611790]
  • Zhidong Wang, Ye Tao, Tianming Qiu, Xiaofeng Yao, Liping Jiang, Ningning Wang, Sen Wei, Xue Jia, Pei Pei, Guang Yang, Xiaofang Liu, Shuang Liu, Xiance Sun. Taurine protected As2O3-induced the activation of hepatic stellate cells through inhibiting PPARα-autophagy pathway. Chemico-biological interactions. 2019 Feb; 300(?):123-130. doi: 10.1016/j.cbi.2019.01.019. [PMID: 30677399]
  • Yi-Shing Leu, Yu-Jen Chen, Chien-Chih Chen, Huey-Lan Huang. Induction of Autophagic Death of Human Hepatocellular Carcinoma Cells by Armillaridin from Armillaria mellea. The American journal of Chinese medicine. 2019; 47(6):1365-1380. doi: 10.1142/s0192415x19500708. [PMID: 31488037]
  • Changhui Diao, Lei Wang, Hao Liu, Yang Du, Xiuheng Liu. Aged kidneys are refractory to autophagy activation in a rat model of renal ischemia-reperfusion injury. Clinical interventions in aging. 2019; 14(?):525-534. doi: 10.2147/cia.s197444. [PMID: 30880933]
  • Gang Qian, Dandan Liu, Lili Hou, Mohammed Hamid, Xingxiang Chen, Fang Gan, Suquan Song, Kehe Huang. Ochratoxin A induces cytoprotective autophagy via blocking AKT/mTOR signaling pathway in PK-15 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2018 Dec; 122(?):120-131. doi: 10.1016/j.fct.2018.09.070. [PMID: 30287338]
  • Jinfang Bao, Yingfeng Shi, Min Tao, Na Liu, Shougang Zhuang, Weijie Yuan. Pharmacological inhibition of autophagy by 3-MA attenuates hyperuricemic nephropathy. Clinical science (London, England : 1979). 2018 11; 132(21):2299-2322. doi: 10.1042/cs20180563. [PMID: 30293967]
  • Songsong Luo, Liping Jiang, Qiannan Li, Xiance Sun, Ting Liu, Fuyang Pei, Tianjiao Zhang, Tiehong Liu, Linlin Dong, Xiaofang Liu, Lijie Jiang. Acrolein-induced autophagy-dependent apoptosis via activation of the lysosomal-mitochondrial pathway in EAhy926 cells. Toxicology in vitro : an international journal published in association with BIBRA. 2018 Oct; 52(?):146-153. doi: 10.1016/j.tiv.2018.05.018. [PMID: 29902662]
  • Tianming Qiu, Pei Pei, Xiaofeng Yao, Liping Jiang, Sen Wei, Zhidong Wang, Jie Bai, Guang Yang, Ni Gao, Lei Yang, Shuangyue Qi, Rushan Yan, Xiaofang Liu, Xiance Sun. Taurine attenuates arsenic-induced pyroptosis and nonalcoholic steatohepatitis by inhibiting the autophagic-inflammasomal pathway. Cell death & disease. 2018 09; 9(10):946. doi: 10.1038/s41419-018-1004-0. [PMID: 30237538]
  • Minghua Liu, Ge Zhao, Dan Zhang, Weixiao An, Honglin Lai, Xiaofang Li, Shousong Cao, Xiukun Lin. Active fraction of clove induces apoptosis via PI3K/Akt/mTOR-mediated autophagy in human colorectal cancer HCT-116 cells. International journal of oncology. 2018 Sep; 53(3):1363-1373. doi: 10.3892/ijo.2018.4465. [PMID: 30015913]
  • Tomohisa Ito, Takashi Ando, Miki Suzuki-Karasaki, Tomohiko Tokunaga, Yukihiro Yoshida, Toyoko Ochiai, Yasuaki Tokuhashi, Yoshihiro Suzuki-Karasaki. Cold PSM, but not TRAIL, triggers autophagic cell death: A therapeutic advantage of PSM over TRAIL. International journal of oncology. 2018 Aug; 53(2):503-514. doi: 10.3892/ijo.2018.4413. [PMID: 29845256]
  • Xia Sheng, Pengfei Zhu, Jianmin Qin, Qi Li. The biological role of autophagy in regulating and controlling the proliferation of liver cancer cells induced by bufalin. Oncology reports. 2018 Jun; 39(6):2931-2941. doi: 10.3892/or.2018.6365. [PMID: 29658591]
  • N Geng, B-J Shi, S-L Li, Z-Y Zhong, Y-C Li, W-L Xua, H Zhou, J-H Cai. Knockdown of ferroportin accelerates erastin-induced ferroptosis in neuroblastoma cells. European review for medical and pharmacological sciences. 2018 06; 22(12):3826-3836. doi: 10.26355/eurrev_201806_15267. [PMID: 29949159]
  • Peng Wang, Chang Gao, Wei Wang, Li-Ping Yao, Jing Zhang, Sun-Dong Zhang, Ji Li, Shao-Hong Fang, Yu-Jie Fu. Juglone induces apoptosis and autophagy via modulation of mitogen-activated protein kinase pathways in human hepatocellular carcinoma cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2018 Jun; 116(Pt B):40-50. doi: 10.1016/j.fct.2018.04.004. [PMID: 29627502]
  • Bing-Xin Chu, Rui-Feng Fan, Shu-Qian Lin, Du-Bao Yang, Zhen-Yong Wang, Lin Wang. Interplay between autophagy and apoptosis in lead(II)-induced cytotoxicity of primary rat proximal tubular cells. Journal of inorganic biochemistry. 2018 05; 182(?):184-193. doi: 10.1016/j.jinorgbio.2018.02.015. [PMID: 29501979]
  • Dóra Júlia Szabó, Richárd Nagymihály, Zoltán Veréb, Natasha Josifovska, Agate Noer, Petra Liskova, Andrea Facskó, Morten C Moe, Goran Petrovski. Ex vivo 3D human corneal stroma model for Schnyder corneal dystrophy - role of autophagy in its pathogenesis and resolution. Histology and histopathology. 2018 May; 33(5):455-462. doi: 10.14670/hh-11-928. [PMID: 28872183]
  • Hou-Long Long, Feng-Feng Zhang, Hong-Ling Wang, Wen-Shi Yang, Hai-Tao Hou, Jing-Kui Yu, Bin Liu. Mulberry anthocyanins improves thyroid cancer progression mainly by inducing apoptosis and autophagy cell death. The Kaohsiung journal of medical sciences. 2018 May; 34(5):255-262. doi: 10.1016/j.kjms.2017.11.004. [PMID: 29699632]
  • Qirui Li, Lingyun Li, Xiaoyuan Fei, Yuanyue Zhang, Chang Qi, Shuyao Hua, Feili Gong, Min Fang. Inhibition of autophagy with 3-methyladenine is protective in a lethal model of murine endotoxemia and polymicrobial sepsis. Innate immunity. 2018 05; 24(4):231-239. doi: 10.1177/1753425918771170. [PMID: 29673286]
  • Lizhen Liao, Xiaodong Zhuang, Weidong Li, Qibiao Su, Jie Zhao, Ying Liu. Polysaccharide from Fuzi protects against Ox‑LDL‑induced calcification of human vascular smooth muscle cells by increasing autophagic activity. Molecular medicine reports. 2018 04; 17(4):5109-5115. doi: 10.3892/mmr.2018.8488. [PMID: 29393437]
  • Haoyuan Jia, Yongmin Yan, Zhaofeng Liang, Nitin Tandra, Bin Zhang, Juanjuan Wang, Wenrong Xu, Hui Qian. Autophagy: A new treatment strategy for MSC-based therapy in acute kidney injury (Review). Molecular medicine reports. 2018 03; 17(3):3439-3447. doi: 10.3892/mmr.2017.8311. [PMID: 29257336]
  • Yuanxing Gu, Yingshan Zhou, Xinfeng Shi, Yongping Xin, Ying Shan, Cong Chen, Tong Cao, Weihuan Fang, Xiaoliang Li. Porcine teschovirus 2 induces an incomplete autophagic response in PK-15 cells. Archives of virology. 2018 Mar; 163(3):623-632. doi: 10.1007/s00705-017-3652-2. [PMID: 29177545]
  • Xugui Li, Qilin Lu, Wei Xie, Yang Wang, Guanqing Wang. Anti-tumor effects of triptolide on angiogenesis and cell apoptosis in osteosarcoma cells by inducing autophagy via repressing Wnt/β-Catenin signaling. Biochemical and biophysical research communications. 2018 02; 496(2):443-449. doi: 10.1016/j.bbrc.2018.01.052. [PMID: 29330051]
  • Ye-Li Zhao, Zhuo-Yu Lu, Xuan Zhang, Wei-Wei Liu, Guo-Dong Yao, Xiao-Ling Liu, Wei Liu, Qing-Jie Wu, Toshihiko Hayashi, Masayuki Yamato, Hitomi Fujisaki, Shunji Hattori, Yuji Atsuzawa, Shin-Ichi Tashiro, Satoshi Onodera, Takashi Ikejima. Gelatin promotes cell aggregation and pro-inflammatory cytokine production in PMA-stimulated U937 cells by augmenting endocytosis-autophagy pathway. The international journal of biochemistry & cell biology. 2018 02; 95(?):132-142. doi: 10.1016/j.biocel.2018.01.002. [PMID: 29307663]
  • Liqian Sun, Manman Zhao, Man Liu, Peng Su, Jingbo Zhang, Youxiang Li, Xinjian Yang, Zhongxue Wu. Suppression of FoxO3a attenuates neurobehavioral deficits after traumatic brain injury through inhibiting neuronal autophagy. Behavioural brain research. 2018 Jan; 337(?):271-279. doi: 10.1016/j.bbr.2017.08.042. [PMID: 28889023]
  • Cai Yan, Tang Yuanjie, Xu Zhengqun, Chen Jiayan, Li Kongdan. Neutrophil Gelatinase-Associated Lipocalin Attenuates Ischemia/Reperfusion Injury in an In Vitro Model via Autophagy Activation. Medical science monitor : international medical journal of experimental and clinical research. 2018 Jan; 24(?):479-485. doi: 10.12659/msm.908158. [PMID: 29367586]
  • Rong Lei, Fei Zhao, Cheng-Yuan Tang, Min Luo, Shi-Kun Yang, Wei Cheng, Xu-Wei Li, Shao-Bin Duan. Mitophagy Plays a Protective Role in Iodinated Contrast-Induced Acute Renal Tubular Epithelial Cells Injury. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2018; 46(3):975-985. doi: 10.1159/000488827. [PMID: 29680838]
  • Bao-Hui Wang, Qun Hou, Yu-Qiang Lu, Meng-Meng Jia, Tao Qiu, Xiao-Hang Wang, Zheng-Xiang Zhang, Yan Jiang. Ketogenic diet attenuates neuronal injury via autophagy and mitochondrial pathways in pentylenetetrazol-kindled seizures. Brain research. 2018 Jan; 1678(?):106-115. doi: 10.1016/j.brainres.2017.10.009. [PMID: 29056525]
  • Lei Wang, Xiankui Li, Cai Chen. 3-methyadenine attenuates chloroform-induced hepatotoxicity via autophagy activation. Biomedical research (Tokyo, Japan). 2018; 39(2):87-94. doi: 10.2220/biomedres.39.87. [PMID: 29669987]
  • Na Liu, Rong Lei, Mi-Mi Tang, Wei Cheng, Min Luo, Qian Xu, Shao-Bin Duan. Autophagy is activated to protect renal tubular epithelial cells against iodinated contrast media‑induced cytotoxicity. Molecular medicine reports. 2017 Dec; 16(6):8277-8282. doi: 10.3892/mmr.2017.7599. [PMID: 28944925]
  • Seung-Mok Lee, Da-In Lee, Sung-Hee Park, Hak-Sun Yu, Ji-Eun Lee, Jong-Soo Lee. Effect of Multipurpose Solution Combined With Autophagy Inhibitors on Adhesion of Acanthamoeba trophozoites to Silicone Hydrogel Contact Lenses. Cornea. 2017 Dec; 36(12):1538-1543. doi: 10.1097/ico.0000000000001340. [PMID: 28834815]
  • Teng Zhao, Hong-Jian Wang, Wen-Wen Zhao, Yi-Ling Sun, Li-Kuan Hu. Gambogic acid improves non-small cell lung cancer progression by inhibition of mTOR signaling pathway. The Kaohsiung journal of medical sciences. 2017 Nov; 33(11):543-549. doi: 10.1016/j.kjms.2017.06.013. [PMID: 29050671]
  • X-H Xu, D-F Ding, H-J Yong, C-L Dong, N You, X-L Ye, M-L Pan, J-H Ma, Q You, Y-B Lu. Resveratrol transcriptionally regulates miRNA-18a-5p expression ameliorating diabetic nephropathy via increasing autophagy. European review for medical and pharmacological sciences. 2017 Nov; 21(21):4952-4965. doi: NULL. [PMID: 29164562]
  • Abhishek Kumar Singh, Akalabya Bissoyi, Mahendra Pratap Kashyap, Pradeep Kumar Patra, Syed Ibrahim Rizvi. Autophagy Activation Alleviates Amyloid-β-Induced Oxidative Stress, Apoptosis and Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells. Neurotoxicity research. 2017 Oct; 32(3):351-361. doi: 10.1007/s12640-017-9746-5. [PMID: 28484969]
  • Soumik BasuRay, Eriks Smagris, Jonathan C Cohen, Helen H Hobbs. The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation. Hepatology (Baltimore, Md.). 2017 10; 66(4):1111-1124. doi: 10.1002/hep.29273. [PMID: 28520213]
  • Koichiro Kawaoka, Shigehiro Doi, Ayumu Nakashima, Kyoko Yamada, Toshinori Ueno, Toshiki Doi, Takao Masaki. Valproic acid attenuates renal fibrosis through the induction of autophagy. Clinical and experimental nephrology. 2017 Oct; 21(5):771-780. doi: 10.1007/s10157-016-1365-6. [PMID: 27928635]
  • Hsin-Yuan Chen, Tsui-Chin Huang, Tzong-Ming Shieh, Chi-Hao Wu, Li-Chun Lin, Shih-Min Hsia. Isoliquiritigenin Induces Autophagy and Inhibits Ovarian Cancer Cell Growth. International journal of molecular sciences. 2017 Sep; 18(10):. doi: 10.3390/ijms18102025. [PMID: 28934130]
  • Sapir Bechor, Dikla Nachmias, Natalie Elia, Yulia Haim, Maayan Vatarescu, Alicia Leikin-Frenkel, Martin Gericke, Tanya Tarnovscki, Guy Las, Assaf Rudich. Adipose tissue conditioned media support macrophage lipid-droplet biogenesis by interfering with autophagic flux. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2017 Sep; 1862(9):1001-1012. doi: 10.1016/j.bbalip.2017.06.012. [PMID: 28652194]
  • Lianghong Kuang, Xiongbin Cao, Zuneng Lu. Baicalein Protects against Rotenone-Induced Neurotoxicity through Induction of Autophagy. Biological & pharmaceutical bulletin. 2017 Sep; 40(9):1537-1543. doi: 10.1248/bpb.b17-00392. [PMID: 28659545]
  • Duanyang Zhang, Wei Qiu, Peng Wang, Pan Zhang, Fang Zhang, PeiP Wang, Yong Sun. Autophagy can alleviate severe burn-induced damage to the intestinal tract in mice. Surgery. 2017 08; 162(2):408-417. doi: 10.1016/j.surg.2017.04.003. [PMID: 28624177]
  • Jing-Hsien Chen, Ming-Shih Lee, Chi-Ping Wang, Cheng-Chin Hsu, Hui-Hsuan Lin. Autophagic effects of Hibiscus sabdariffa leaf polyphenols and epicatechin gallate (ECG) against oxidized LDL-induced injury of human endothelial cells. European journal of nutrition. 2017 Aug; 56(5):1963-1981. doi: 10.1007/s00394-016-1239-4. [PMID: 27318926]
  • Junn-Liang Chang, Jyh-Ming Chow, Jer-Hwa Chang, Yu-Ching Wen, Yung-Wei Lin, Shun-Fa Yang, Wei-Jiunn Lee, Ming-Hsien Chien. Quercetin simultaneously induces G0 /G1 -phase arrest and caspase-mediated crosstalk between apoptosis and autophagy in human leukemia HL-60 cells. Environmental toxicology. 2017 Jul; 32(7):1857-1868. doi: 10.1002/tox.22408. [PMID: 28251795]
  • Ki Won Lee, Hyung Won Ryu, Sang-Seok Oh, Soojong Park, Hamadi Madhi, Jiyun Yoo, Ki-Hun Park, Kwang Dong Kim. Depigmentation of α-melanocyte-stimulating hormone-treated melanoma cells by β-mangostin is mediated by selective autophagy. Experimental dermatology. 2017 07; 26(7):585-591. doi: 10.1111/exd.13233. [PMID: 27714857]
  • Wenmin Yu, Zhi Wang, Yiping Li, Lei Liu, Jing Liu, Fenggan Ding, Xiaoyi Zhang, Zhengyuan Cheng, Pingsheng Chen. Effects of autophagy and endocytosis on the activity of matrix metalloproteinase‑2 in human renal proximal tubular cells under hypoxia. Molecular medicine reports. 2017 May; 15(5):3225-3230. doi: 10.3892/mmr.2017.6358. [PMID: 28339082]
  • Xiao-Qian Zhang, Jian-Jun Dong, Tian Cai, Xue Shen, Xiao-Jun Zhou, Lin Liao. High glucose induces apoptosis via upregulation of Bim expression in proximal tubule epithelial cells. Oncotarget. 2017 Apr; 8(15):24119-24129. doi: 10.18632/oncotarget.15491. [PMID: 28445931]
  • Bingying Wang, Haoyuan Jia, Bin Zhang, Juanjuan Wang, Cheng Ji, Xueming Zhu, Yongmin Yan, Lei Yin, Jing Yu, Hui Qian, Wenrong Xu. Pre-incubation with hucMSC-exosomes prevents cisplatin-induced nephrotoxicity by activating autophagy. Stem cell research & therapy. 2017 04; 8(1):75. doi: 10.1186/s13287-016-0463-4. [PMID: 28388958]
  • Scott G Harroun, Yaoting Zhang, Tzu-Heng Chen, Ching-Rong Ku, Huan-Tsung Chang. Biomarkers of cigarette smoking and DNA methylating agents: Raman, SERS and DFT study of 3-methyladenine and 7-methyladenine. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2017 Apr; 176(?):1-7. doi: 10.1016/j.saa.2016.12.012. [PMID: 28061366]
  • Wen Gu, Rong Cui, Tao Ding, Xiaoming Li, Juan Peng, Weiguo Xu, Fengfeng Han, Xuejun Guo. Simvastatin alleviates airway inflammation and remodelling through up-regulation of autophagy in mouse models of asthma. Respirology (Carlton, Vic.). 2017 04; 22(3):533-541. doi: 10.1111/resp.12926. [PMID: 27782356]
  • Neda Feizi, Parvaneh Mehrbod, Bizhan Romani, Hoorieh Soleimanjahi, Taravat Bamdad, Amir Feizi, Ehsan Ollah Jazaeri, Hadiseh Shokouhi Targhi, Maryam Saleh, Abbas Jamali, Fatemeh Fotouhi, Reza Nasrollahi Nargesabad, Asghar Abdoli. Autophagy induction regulates influenza virus replication in a time-dependent manner. Journal of medical microbiology. 2017 Apr; 66(4):536-541. doi: 10.1099/jmm.0.000455. [PMID: 28463668]
  • Renlong Li, Enshuang Guo, Jiankun Yang, Anyi Li, Yan Yang, Shenpei Liu, Anding Liu, Xiaojing Jiang. 1,25(OH)2 D3 attenuates hepatic steatosis by inducing autophagy in mice. Obesity (Silver Spring, Md.). 2017 03; 25(3):561-571. doi: 10.1002/oby.21757. [PMID: 28145056]
  • Hongbo Shi, Honglin Shi, Feng Ren, Dexi Chen, Yu Chen, Zhongping Duan. Naringin in Ganshuang Granule suppresses activation of hepatic stellate cells for anti-fibrosis effect by inhibition of mammalian target of rapamycin. Journal of cellular and molecular medicine. 2017 03; 21(3):500-509. doi: 10.1111/jcmm.12994. [PMID: 27687505]
  • Yu-Hong Jing, Lang Zhang, Li-Ping Gao, Chu-Chu Qi, Dan-Dan Lv, Yan-Feng Song, Jie Yin, De-Gui Wang. Autophagy plays beneficial effect on diabetic encephalopathy in type 2 diabetes: studies in vivo and in vitro. Neuro endocrinology letters. 2017 Feb; 38(1):27-37. doi: ". [PMID: 28456145]
  • Raquel Pascua-Maestro, Sergio Diez-Hermano, Concepción Lillo, Maria D Ganfornina, Diego Sanchez. Protecting cells by protecting their vulnerable lysosomes: Identification of a new mechanism for preserving lysosomal functional integrity upon oxidative stress. PLoS genetics. 2017 02; 13(2):e1006603. doi: 10.1371/journal.pgen.1006603. [PMID: 28182653]