Zongorine (BioDeep_00000000177)

 

Secondary id: BioDeep_00000410491

PANOMIX_OTCML-2023


代谢物信息卡片


(1R,2R,5S,7R,8R,9R,13R,16S,17R)-11-ethyl-7,16-dihydroxy-13-methyl-6-methylidene-11-azahexacyclo[7.7.2.15,8.01,10.02,8.013,17]nonadecan-4-one

化学式: C22H31NO3 (357.2303816)
中文名称: 准葛尔乌头碱, 一枝蒿庚素, 宋果灵, 准葛尔乌头碱
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 20.08%

分子结构信息

SMILES: C=C1C2CC3(C1O)C1CC4C5(C)CCC(O)C4(C1N(CC)C5)C3CC2=O
InChI: InChI=1S/C22H31NO3/c1-4-23-10-20(3)6-5-17(25)22-15(20)7-13(18(22)23)21-9-12(11(2)19(21)26)14(24)8-16(21)22/h12-13,15-19,25-26H,2,4-10H2,1,3H3/t12-,13-,15+,16+,17-,18?,19+,20-,21-,22-/m0/s1

描述信息

Songorine is a kaurane diterpenoid.
Songorine is a diterpenoid alkaloid isolated from the genus Aconitum. Songorine is a GABAA receptor antagonist in rat brain and has anti cancer, antiarrhythmic and anti-inflammatory activities. Songorine has the potential for the treatment of Epithelial ovarian cancer (EOC)[1].
Songorine is a diterpenoid alkaloid isolated from the genus Aconitum. Songorine is a GABAA receptor antagonist in rat brain and has anti cancer, antiarrhythmic and anti-inflammatory activities. Songorine has the potential for the treatment of Epithelial ovarian cancer (EOC)[1].
Songorine is a diterpenoid alkaloid isolated from the genus Aconitum. Songorine is a GABAA receptor antagonist in rat brain and has anti cancer, antiarrhythmic and anti-inflammatory activities. Songorine has the potential for the treatment of Epithelial ovarian cancer (EOC)[1].

同义名列表

8 个代谢物同义名

(1R,2R,5S,7R,8R,9R,13R,16S,17R)-11-ethyl-7,16-dihydroxy-13-methyl-6-methylidene-11-azahexacyclo[7.7.2.15,8.01,10.02,8.013,17]nonadecan-4-one; songorine hydrochloride; STOCK1N-51040; Napellonine; Bullatine G; Zongorine; songorine; Bullatine



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

46 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xiaocui Li, Weiqing Hou, Tingting Lin, Jiadong Ni, Huawei Qiu, Yu Fu, Zhongxiang Zhao, Caihua Yang, Na Li, Hua Zhou, Rong Zhang, Zhongqiu Liu, Ling Fu, Lijun Zhu. Neoline, fuziline, songorine and 10-OH mesaconitine are potential quality markers of Fuzi: In vitro and in vivo explorations as well as pharmacokinetics, efficacy and toxicity evaluations. Journal of ethnopharmacology. 2023 Mar; 303(?):115879. doi: 10.1016/j.jep.2022.115879. [PMID: 36370966]
  • Haolong Liu, Feng Qiu, Haiyu Zhao, Baolin Bian, Lei Wang. Simultaneous high-performance liquid chromatography with tandem mass spectrometry quantification of six bioactive components in rat plasma after oral administration of Yougui pill. Journal of separation science. 2019 May; 42(10):1867-1877. doi: 10.1002/jssc.201800772. [PMID: 30868717]
  • Jiangming Wang, Changhao Bian, Yinan Wang, Quan Shen, Bin Bao, Junting Fan, Aixue Zuo, Wenhui Wu, Ruihua Guo. Syntheses and bioactivities of songorine derivatives as novel G protein-coupled receptor antagonists. Bioorganic & medicinal chemistry. 2019 05; 27(9):1903-1910. doi: 10.1016/j.bmc.2019.03.045. [PMID: 30926314]
  • Weiming Xu, Min Zhang, Hongwu Liu, Kun Wei, Ming He, Xiangyang Li, Deyu Hu, Song Yang, Yuguo Zheng. Antiviral activity of aconite alkaloids from Aconitum carmichaelii Debx. Natural product research. 2019 May; 33(10):1486-1490. doi: 10.1080/14786419.2017.1416385. [PMID: 29271255]
  • Guangguo Tan, Xin Wang, Kui Liu, Xin Dong, Wenting Liao, Hong Wu. Correlation of drug-induced and drug-related ultra-high performance liquid chromatography-mass spectrometry serum metabolomic profiles yields discovery of effective constituents of Sini decoction against myocardial ischemia in rats. Food & function. 2018 Nov; 9(11):5528-5535. doi: 10.1039/c8fo01217b. [PMID: 30209468]
  • Ahmatbeck Samanbay, Bo Zhao, Haji Akber Aisa. A new denudatine type C20-diterpenoid alkaloid from Aconitum sinchiangense W. T. Wang. Natural product research. 2018 Oct; 32(19):2319-2324. doi: 10.1080/14786419.2017.1410814. [PMID: 29212360]
  • G N Zyuz'kov, E V Udut, L A Miroshnichenko, T Yu Polyakova, E V Simanina, L A Stavrova, G A Prosekin, V V Zhdanov, V V Udut. Role of JAK/STAT3 Signaling in Functional Stimulation of Mesenchymal Progenitor Cells with Alkaloid Songorine. Bulletin of experimental biology and medicine. 2018 Sep; 165(5):665-668. doi: 10.1007/s10517-018-4237-0. [PMID: 30225700]
  • Haroon Khan, Seyed Mohammad Nabavi, Antoni Sureda, Nikolay Mehterov, Diana Gulei, Ioana Berindan-Neagoe, Hiroaki Taniguchi, Atanas G Atanasov. Therapeutic potential of songorine, a diterpenoid alkaloid of the genus Aconitum. European journal of medicinal chemistry. 2018 Jun; 153(?):29-33. doi: 10.1016/j.ejmech.2017.10.065. [PMID: 29133056]
  • Yao-yao Dong, Baiping Mao, Hongguo Guan, Yanfang Bai, Binghuan Chi, Yuan-yuan Shan, Qing-Quan Lian, Ren-shan Ge. Determination of songorine in rat plasma by UPLC-MS/MS: Assay development and application to pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2015 Oct; 1002(?):234-8. doi: 10.1016/j.jchromb.2015.08.037. [PMID: 26342165]
  • Yu V Nesterova, T N Povet'yeva, N I Suslov, G N Zyuz'kov, S V Pushkarskii, S G Aksinenko, E E Schultz, S S Kravtsova, A V Krapivin. Analgesic activity of diterpene alkaloids from Aconitum baikalensis. Bulletin of experimental biology and medicine. 2014 Aug; 157(4):488-91. doi: 10.1007/s10517-014-2598-6. [PMID: 25110090]
  • Hui Sun, Mo Wang, Aihua Zhang, Bei Ni, Hui Dong, Xijun Wang. UPLC-Q-TOF-HDMS analysis of constituents in the root of two kinds of Aconitum using a metabolomics approach. Phytochemical analysis : PCA. 2013 May; 24(3):263-76. doi: 10.1002/pca.2407. [PMID: 23225552]
  • Yu V Nesterova, T N Povetieva, N I Suslov, V V Zhdanov, T Yu Hrichkova, E V Udut, A S Chaykovskiy, N N Gaydamovich, T I Andreeva, A M Dygai. Regeneratory characteristics of complex extract and isolated diterpene alkaloids of Aconitum baikalense. Bulletin of experimental biology and medicine. 2012 Feb; 152(4):439-43. doi: 10.1007/s10517-012-1548-4. [PMID: 22803106]
  • A Ameri. Effects of the Aconitum alkaloid songorine on synaptic transmission and paired-pulse facilitation of CA1 pyramidal cells in rat hippocampal slices. British journal of pharmacology. 1998 Oct; 125(3):461-8. doi: 10.1038/sj.bjp.0702100. [PMID: 9806328]