N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide (BioDeep_00000175188)
human metabolite blood metabolite
代谢物信息卡片
N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enimidate
化学式: C18H27NO3 (305.1991)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 57.53%
分子结构信息
SMILES: COC1=CC(CNC(=O)CCCCC=CC(C)C)=CC=C1O
InChI: InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
4 个相关的物种来源信息
- 4071 - Capsicum: 10.3892/OR_00000269
- 4072 - Capsicum annuum:
- 113210 - Capsicum pubescens: 10.1055/S-0028-1097200
- 9606 - Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zhenyu Liu, Weili Wang, Xueqin Li, Sha Tang, Dongwei Meng, Wenli Xia, Hong Wang, Yuzhang Wu, Xinyuan Zhou, Jingbo Zhang. Capsaicin ameliorates renal fibrosis by inhibiting TGF-β1-Smad2/3 signaling.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Jun; 100(?):154067. doi:
10.1016/j.phymed.2022.154067. [PMID: 35349832] - Dongling Luo, Wenxin Li, Changming Xie, Li Yin, Xiaoyan Su, Jie Chen, Hui Huang. Capsaicin Attenuates Arterial Calcification Through Promoting SIRT6-Mediated Deacetylation and Degradation of Hif1α (Hypoxic-Inducible Factor-1 Alpha).
Hypertension (Dallas, Tex. : 1979).
2022 05; 79(5):906-917. doi:
10.1161/hypertensionaha.121.18778. [PMID: 35232219] - Yue Qiao, Yang Zhang, Zhenrui Qiao, Wenya He, Yingda Chen, Depu Song, Guohao Wang, Ning Guo, Lulian Shao, Zhiyong Tian, Qiang Wang, Lin Yan, Hai Qian. Discovery of (S)-N-(3-isopropylphenyl)-2-(5-phenylthiazol-2-yl)pyrrolidine-1-carboxamide as potent and brain-penetrant TRPV1 antagonist.
European journal of medicinal chemistry.
2022 Apr; 233(?):114191. doi:
10.1016/j.ejmech.2022.114191. [PMID: 35263708] - Mikako Yoshikawa, Retsu Mitsui, Hiromichi Takano, Hikaru Hashitani. Mechanosensitive modulation of peristaltic contractions in the mouse renal pelvis.
European journal of pharmacology.
2022 Apr; 920(?):174834. doi:
10.1016/j.ejphar.2022.174834. [PMID: 35183536] - Yu-Shan Chen, Yu Zhi Lian, Wen-Chao Chen, Chun-Chao Chang, Alexey A Tinkov, Anatoly V Skalny, Jane C-J Chao. Lycium barbarum Polysaccharides and Capsaicin Inhibit Oxidative Stress, Inflammatory Responses, and Pain Signaling in Rats with Dextran Sulfate Sodium-Induced Colitis.
International journal of molecular sciences.
2022 Feb; 23(5):. doi:
10.3390/ijms23052423. [PMID: 35269566] - Ankita Chaudhary, Jalaj Kumar Gour, Syed Ibrahim Rizvi. Capsaicin has potent anti-oxidative effects in vivo through a mechanism which is non-receptor mediated.
Archives of physiology and biochemistry.
2022 Feb; 128(1):141-147. doi:
10.1080/13813455.2019.1669056. [PMID: 31566018] - Judit Rosta, Máté Tóth, Nadine Friedrich, Péter Sántha, Gábor Jancsó, Mária Dux. Insulin sensitizes neural and vascular TRPV1 receptors in the trigeminovascular system.
The journal of headache and pain.
2022 Jan; 23(1):7. doi:
10.1186/s10194-021-01380-x. [PMID: 35033025] - Qiuyue Wang, Caihui Zhang, Chen Yang, Yue Sun, Keyang Chen, Yao Lu. Capsaicin Alleviates Vascular Endothelial Dysfunction and Cardiomyopathy via TRPV1/eNOS Pathway in Diabetic Rats.
Oxidative medicine and cellular longevity.
2022; 2022(?):6482363. doi:
10.1155/2022/6482363. [PMID: 35602097] - Fei Ran, Yi Yang, Lun Yang, Shichao Chen, Ping He, Qiting Liu, Qingliang Zou, Dan Wang, Jixin Hou, Peijian Wang. Capsaicin Prevents Contrast-Associated Acute Kidney Injury through Activation of Nrf2 in Mice.
Oxidative medicine and cellular longevity.
2022; 2022(?):1763922. doi:
10.1155/2022/1763922. [PMID: 35615576] - Marco Kreidl, Matthias Rainer, Günther K Bonn, Herbert Oberacher. Electrochemical Simulation of the Oxidative Capsaicin Metabolism.
Chemical research in toxicology.
2021 12; 34(12):2522-2533. doi:
10.1021/acs.chemrestox.1c00288. [PMID: 34879203] - Mark S Wallace. Effect of Pregabalin on the Median Effective Plasma Concentration of Intravenous Alfentanil in Capsaicin-Induced Pain.
Pain medicine (Malden, Mass.).
2021 Dec; 22(12):3072-3079. doi:
10.1093/pm/pnab222. [PMID: 34329455] - Mayara Alves Amorim, Janiana Raíza Jentsch Matias de Oliveira, Vitor Hélio Souza Oliveira, Daniela Almeida Cabrini, Michel Fleith Otuki, Eunice André. Role of nitric oxide, bradykinin B2 receptor, and TRPV1 in the airway alterations caused by simvastatin in rats.
European journal of pharmacology.
2021 Dec; 912(?):174591. doi:
10.1016/j.ejphar.2021.174591. [PMID: 34710369] - Sara A Aldossary, Muhammad Shahzad Chohan, Mohammed Al Mohaini, Sahibzada Tasleem Rasool. Capsaicin ameliorate the nephrotoxicity induced by methotrexate.
Pakistan journal of pharmaceutical sciences.
2021 Nov; 34(6):2191-2195. doi:
NULL. [PMID: 35034880] - Suk-Yun Kang, Su Yeon Seo, Se Kyun Bang, Seong Jin Cho, Kwang-Ho Choi, Yeonhee Ryu. Inhibition of Spinal TRPV1 Reduces NMDA Receptor 2B Phosphorylation and Produces Anti-Nociceptive Effects in Mice with Inflammatory Pain.
International journal of molecular sciences.
2021 Oct; 22(20):. doi:
10.3390/ijms222011177. [PMID: 34681836] - Yanxin Li, Xiaoying Chen, Yingying Nie, Yuhua Tian, Xian Xiao, Fan Yang. Endocannabinoid activation of the TRPV1 ion channel is distinct from activation by capsaicin.
The Journal of biological chemistry.
2021 09; 297(3):101022. doi:
10.1016/j.jbc.2021.101022. [PMID: 34332978] - Kazim Sahin, Osman Kucuk, Cemal Orhan, Emre Sahin, Kelli Fowler, Tyler White, Shane Durkee, Aouatef Bellamine. Bioavailability of a Capsaicin Lipid Multi-particulate Formulation in Rats.
European journal of drug metabolism and pharmacokinetics.
2021 Sep; 46(5):645-650. doi:
10.1007/s13318-021-00697-x. [PMID: 34287807] - Leon J DeLalio, Sean D Stocker. Impact of anesthesia and sex on sympathetic efferent and hemodynamic responses to renal chemo- and mechanosensitive stimuli.
Journal of neurophysiology.
2021 08; 126(2):668-679. doi:
10.1152/jn.00277.2021. [PMID: 34259043] - Yingying Nie, Yanxin Li, Lei Liu, Shouyan Ren, Yuhua Tian, Fan Yang. Molecular mechanism underlying modulation of TRPV1 heat activation by polyols.
The Journal of biological chemistry.
2021 07; 297(1):100806. doi:
10.1016/j.jbc.2021.100806. [PMID: 34022223] - Anne-Sofie Ravn Ballegaard, Jeppe Madura Larsen, Peter Have Rasmussen, Eva Untersmayr, Kirsten Pilegaard, Katrine Lindholm Bøgh. Quinoa (Chenopodium quinoa Willd.) Seeds Increase Intestinal Protein Uptake.
Molecular nutrition & food research.
2021 07; 65(13):e2100102. doi:
10.1002/mnfr.202100102. [PMID: 33939283] - Kaori Takahashi, Takashi Yoshida, Minoru Wakamori. Mode-selective inhibitory effects of eugenol on the mouse TRPV1 channel.
Biochemical and biophysical research communications.
2021 06; 556(?):156-162. doi:
10.1016/j.bbrc.2021.03.126. [PMID: 33839411] - Stewart Christie, Vladimir Zagorodnyuk. CB2 cannabinoid receptor agonist selectively inhibits the mechanosensitivity of mucosal afferents in the guinea pig bladder.
American journal of physiology. Renal physiology.
2021 05; 320(5):F859-F865. doi:
10.1152/ajprenal.00065.2021. [PMID: 33749323] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Shuang-Quan Yu, Shuangtao Ma, Donna H Wang. Ablation of TRPV1-positive nerves exacerbates salt-induced hypertension and tissue injury in rats after renal ischemia-reperfusion via infiltration of macrophages.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2021 Apr; 43(3):254-262. doi:
10.1080/10641963.2020.1860078. [PMID: 33327798] - J M Viveros-Paredes, A M Puebla-Pérez, O Gutiérrez-Coronado, A M Macías-Lamas, G Hernández-Flores, P C Ortiz-Lazareno, A Bravo-Cuéllar, M M Villaseñor-García. Capsaicin attenuates immunosuppression induced by chronic stress in BALB/C mice.
International immunopharmacology.
2021 Apr; 93(?):107341. doi:
10.1016/j.intimp.2020.107341. [PMID: 33486334] - Luis Apaza Ticona, Ángel Rumbero Sánchez, Cristina Thiebaut Estrada, Olga M Palomino. Identification of TRPV1 Ion Channels Agonists of Tropaeolum tuberosum in Human Skin Keratinocytes.
Planta medica.
2021 Apr; 87(5):383-394. doi:
10.1055/a-1264-0572. [PMID: 33007786] - J G Liu, W G Xia, W Chen, K F M Abouelezz, D Ruan, S Wang, Y N Zhang, X B Huang, K C Li, C T Zheng, J P Deng. Effects of capsaicin on laying performance, follicle development, and ovarian antioxidant capacity in aged laying ducks.
Poultry science.
2021 Apr; 100(4):100901. doi:
10.1016/j.psj.2020.11.070. [PMID: 33667870] - Joanna K Bujak, Daria Kosmala, Kinga Majchrzak-Kuligowska, Piotr Bednarczyk. Functional Expression of TRPV1 Ion Channel in the Canine Peripheral Blood Mononuclear Cells.
International journal of molecular sciences.
2021 Mar; 22(6):. doi:
10.3390/ijms22063177. [PMID: 33804707] - Bálint Botz, Gábor Kriszta, Kata Bölcskei, Ádám István Horváth, Attila Mócsai, Zsuzsanna Helyes. Capsaicin-Sensitive Peptidergic Sensory Nerves Are Anti-Inflammatory Gatekeepers in the Hyperacute Phase of a Mouse Rheumatoid Arthritis Model.
International journal of molecular sciences.
2021 Feb; 22(4):. doi:
10.3390/ijms22041682. [PMID: 33567493] - Ivan Urits, Nathan Li, Amnon A Berger, Paul Walker, Brendan Wesp, Alec M Zamarripa, Daniel An, Elyse M Cornett, Alaa Abd-Elsayed, Alan D Kaye. Treatment and Management of Loin Pain Hematuria Syndrome.
Current pain and headache reports.
2021 Jan; 25(1):6. doi:
10.1007/s11916-020-00925-0. [PMID: 33495883] - Chunliang Xu, Maria Gulinello, Paul S Frenette. Nociceptors protect sickle cell disease mice from vaso-occlusive episodes and chronic organ damage.
The Journal of experimental medicine.
2021 01; 218(1):. doi:
10.1084/jem.20200065. [PMID: 33045060] - Jing Xia, Li Gu, Yitong Guo, Hongyan Feng, Shuhan Chen, Jessore Jurat, Wenjing Fu, Dongfang Zhang. Gut Microbiota Mediates the Preventive Effects of Dietary Capsaicin Against Depression-Like Behavior Induced by Lipopolysaccharide in Mice.
Frontiers in cellular and infection microbiology.
2021; 11(?):627608. doi:
10.3389/fcimb.2021.627608. [PMID: 33987106] - Wimonrat Panpetch, Peerapat Visitchanakun, Wilasinee Saisorn, Ajcharaporn Sawatpanich, Piraya Chatthanathon, Naraporn Somboonna, Somying Tumwasorn, Asada Leelahavanichkul. Lactobacillus rhamnosus attenuates Thai chili extracts induced gut inflammation and dysbiosis despite capsaicin bactericidal effect against the probiotics, a possible toxicity of high dose capsaicin.
PloS one.
2021; 16(12):e0261189. doi:
10.1371/journal.pone.0261189. [PMID: 34941893] - Leon J DeLalio, Sean D Stocker. Impact of anesthesia, sex, and circadian cycle on renal afferent nerve sensitivity.
American journal of physiology. Heart and circulatory physiology.
2021 01; 320(1):H117-H132. doi:
10.1152/ajpheart.00675.2020. [PMID: 33216622] - Chieh-Hsin Wu, Ming-Kung Wu, Chun-Ching Lu, Hung-Pei Tsai, Ying-Yi Lu, Chih-Lung Lin. Impact of Hepatoma-Derived Growth Factor Blockade on Resiniferatoxin-Induced Neuropathy.
Neural plasticity.
2021; 2021(?):8854461. doi:
10.1155/2021/8854461. [PMID: 33727914] - Sara AlMarabeh, Julie O'Neill, Jeremy Cavers, Eric F Lucking, Ken D O'Halloran, Mohammed H Abdulla. Chronic intermittent hypoxia impairs diuretic and natriuretic responses to volume expansion in rats with preserved low-pressure baroreflex control of the kidney.
American journal of physiology. Renal physiology.
2021 01; 320(1):F1-F16. doi:
10.1152/ajprenal.00377.2020. [PMID: 33166181] - Fan Deng, Bing-Cheng Zhao, Xiao Yang, Ze-Bin Lin, Qi-Shun Sun, Yi-Fan Wang, Zheng-Zheng Yan, Wei-Feng Liu, Cai Li, Jing-Juan Hu, Ke-Xuan Liu. The gut microbiota metabolite capsiate promotes Gpx4 expression by activating TRPV1 to inhibit intestinal ischemia reperfusion-induced ferroptosis.
Gut microbes.
2021 Jan; 13(1):1-21. doi:
10.1080/19490976.2021.1902719. [PMID: 33779497] - Luis Manuel Sarmiento-Machado, Guilherme Ribeiro Romualdo, Joyce Regina Zapaterini, Mariana Baptista Tablas, Ana Angélica Henrique Fernandes, Fernando Salvador Moreno, Luís Fernando Barbisan. Protective Effects of Dietary Capsaicin on the Initiation Step of a Two-Stage Hepatocarcinogenesis Rat Model.
Nutrition and cancer.
2021; 73(5):817-828. doi:
10.1080/01635581.2020.1764067. [PMID: 32400193] - Kristina Rodionova, Karl F Hilgers, Eva-Maria Paulus, Gisa Tiegs, Christian Ott, Roland Schmieder, Mario Schiffer, Kerstin Amann, Roland Veelken, Tilmann Ditting. Neurogenic tachykinin mechanisms in experimental nephritis of rats.
Pflugers Archiv : European journal of physiology.
2020 12; 472(12):1705-1717. doi:
10.1007/s00424-020-02469-z. [PMID: 33070237] - Monika Kubacka, Anna Rapacz, Kinga Sałat, Barbara Filipek, Agnieszka Cios, Krzysztof Pociecha, Elżbieta Wyska, Urszula Hubicka, Barbara Żuromska-Witek, Anna Kwiecień, Henryk Marona, Anna M Waszkielewicz. KM-416, a novel phenoxyalkylaminoalkanol derivative with anticonvulsant properties exerts analgesic, local anesthetic, and antidepressant-like activities. Pharmacodynamic, pharmacokinetic, and forced degradation studies.
European journal of pharmacology.
2020 Nov; 886(?):173540. doi:
10.1016/j.ejphar.2020.173540. [PMID: 32896552] - Fen Zheng, Chao Ye, Guo-Wei Wan, Bing Zhou, Ying Tong, Jian-Zhen Lei, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu. Interleukin-1β in hypothalamic paraventricular nucleus mediates excitatory renal reflex.
Pflugers Archiv : European journal of physiology.
2020 11; 472(11):1577-1586. doi:
10.1007/s00424-020-02461-7. [PMID: 32915316] - Hugues Petitjean, Tarheen Fatima, Stephanie Mouchbahani-Constance, Albena Davidova, Catherine E Ferland, John Orlowski, Reza Sharif-Naeini. Loss of SLC9A6/NHE6 impairs nociception in a mouse model of Christianson syndrome.
Pain.
2020 11; 161(11):2619-2628. doi:
10.1097/j.pain.0000000000001961. [PMID: 32569089] - Feifei Cui, Qingmei Yin, Chao Wu, Meifen Shen, Yijie Zhang, Chen Ma, Haiying Zhang, Fang Shen. Capsaicin combined with ice stimulation improves swallowing function in patients with dysphagia after stroke: A randomised controlled trial.
Journal of oral rehabilitation.
2020 Oct; 47(10):1297-1303. doi:
10.1111/joor.13068. [PMID: 32757479] - Jihang Chen, Wing Man Chan, Hoi Yan Leung, Pou Kuan Leong, Choly Tat Ming Yan, Kam Ming Ko. Anti-Inflammatory Effects of a Cordyceps sinensis Mycelium Culture Extract (Cs-4) on Rodent Models of Allergic Rhinitis and Asthma.
Molecules (Basel, Switzerland).
2020 Sep; 25(18):. doi:
10.3390/molecules25184051. [PMID: 32899766] - Zhi-Cheng Wang, Bingyan Wei, Fang-Ning Pei, Teng Yang, Jie Tang, Song Yang, Li-Fang Yu, Cai-Guang Yang, Fan Yang. Capsaicin derivatives with nitrothiophene substituents: Design, synthesis and antibacterial activity against multidrug-resistant S. aureus.
European journal of medicinal chemistry.
2020 Jul; 198(?):112352. doi:
10.1016/j.ejmech.2020.112352. [PMID: 32387838] - Lijuan Sun, Hui Jen Goh, Priya Govindharajulu, Lei Sun, Christiani Jeyakumar Henry, Melvin Khee-Shing Leow. A Feedforward Loop within the Thyroid-Brown Fat Axis Facilitates Thermoregulation.
Scientific reports.
2020 06; 10(1):9661. doi:
10.1038/s41598-020-66697-0. [PMID: 32541662] - Yukiko Segawa, Hiroko Hashimoto, Saki Maruyama, Miki Shintani, Hitomi Ohno, Yuko Nakai, Tomoko Osera, Nobutaka Kurihara. Dietary capsaicin-mediated attenuation of hypertension in a rat model of renovascular hypertension.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2020 May; 42(4):352-359. doi:
10.1080/10641963.2019.1665676. [PMID: 31518162] - Kenichi Katsurada, Shyam S Nandi, Hong Zheng, Xuefei Liu, Neeru M Sharma, Kaushik P Patel. GLP-1 mediated diuresis and natriuresis are blunted in heart failure and restored by selective afferent renal denervation.
Cardiovascular diabetology.
2020 05; 19(1):57. doi:
10.1186/s12933-020-01029-0. [PMID: 32384887] - Lin Ming Lu, Ting Ting Yu, Xiao Wei He, Juan Tang, Xian Wei Li. [Effect of small dose capsaicin for treatment of pulmonary fibrosis in mice and its mechanism].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2020 May; 36(3):216-222. doi:
10.12047/j.cjap.5974.2020.048. [PMID: 32981275] - Yun Qiu, Fen Zheng, Chao Ye, Ai-Dong Chen, Jue-Jin Wang, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu. Angiotensin Type 1 Receptors and Superoxide Anion Production in Hypothalamic Paraventricular Nucleus Contribute to Capsaicin-Induced Excitatory Renal Reflex and Sympathetic Activation.
Neuroscience bulletin.
2020 May; 36(5):463-474. doi:
10.1007/s12264-019-00460-y. [PMID: 31989424] - Chao Ye, Yun Qiu, Feng Zhang, Ai-Dong Chen, Hong Zhou, Jue-Jin Wang, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu. Chemical Stimulation of Renal Tissue Induces Sympathetic Activation and a Pressor Response via the Paraventricular Nucleus in Rats.
Neuroscience bulletin.
2020 Feb; 36(2):143-152. doi:
10.1007/s12264-019-00417-1. [PMID: 31392556] - Shuang-Quan Yu, Shuangtao Ma, Donna H Wang. TRPV1 Activation Prevents Renal Ischemia-Reperfusion Injury-Induced Increase in Salt Sensitivity by Suppressing Renal Sympathetic Nerve Activity.
Current hypertension reviews.
2020; 16(2):148-155. doi:
10.2174/1573402115666191112122339. [PMID: 31721716] - Barbora Melkes, Vendula Markova, Lucie Hejnova, Ales Marek, Jiri Novotny. Naloxone Is a Potential Binding Ligand and Activator of the Capsaicin Receptor TRPV1.
Biological & pharmaceutical bulletin.
2020; 43(5):908-912. doi:
10.1248/bpb.b19-00806. [PMID: 32378567] - Verena Stoeger, Barbara Lieder, Johanna Riedel, Kerstin Schweiger, Julia Hoi, Veronika Ruzsanyi, Martin Klieber, Petra Rust, Joachim Hans, Jakob P Ley, Gerhard E Krammer, Veronika Somoza. Wheat Protein Hydrolysate Fortified With l-Arginine Enhances Satiation Induced by the Capsaicinoid Nonivamide in Moderately Overweight Male Subjects.
Molecular nutrition & food research.
2019 12; 63(23):e1900133. doi:
10.1002/mnfr.201900133. [PMID: 31535460] - Vivian Shinobu Kishimoto Nishihira, Alexandre Machado Rubim, Morgana Brondani, Jessica Tadiello Dos Santos, Ariane Ribas Pohl, Jadriane Fontoura Friedrich, Jéssica Dotto de Lara, Christian Masseron Nunes, Luciane Rosa Feksa, Eder Simão, Rodrigo de Almeida Vaucher, Michael Gonzalez Durruthy, Luciane Varini Laporta, Virginia Cielo Rech. In vitro and in silico protein corona formation evaluation of curcumin and capsaicin loaded-solid lipid nanoparticles.
Toxicology in vitro : an international journal published in association with BIBRA.
2019 Dec; 61(?):104598. doi:
10.1016/j.tiv.2019.104598. [PMID: 31299314] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Hsien-Tsung Yao, Jia-Hsuan Lin, Yun-Ta Liu, Mei-Ling Li, Wenchang Chiang. Food-Drug Interaction between the Adlay Bran Oil and Drugs in Rats.
Nutrients.
2019 Oct; 11(10):. doi:
10.3390/nu11102473. [PMID: 31618937] - Lu Liu, Cheng Ding, Min Tian, Dongzheng Yi, Jun Wang, Jinyue Zhao, Yong Hu, Chao Wang. Fermentation improves the potentiality of capsicum in decreasing high-fat diet-induced obesity in C57BL/6 mice by modulating lipid metabolism and hormone response.
Food research international (Ottawa, Ont.).
2019 10; 124(?):49-60. doi:
10.1016/j.foodres.2018.10.015. [PMID: 31466650] - Juan Carlos Torres-Narváez, Israel Pérez-Torres, Vicente Castrejón-Téllez, Elvira Varela-López, Víctor Hugo Oidor-Chan, Verónica Guarner-Lans, Álvaro Vargas-González, Raúl Martínez-Memije, Pedro Flores-Chávez, Etzna Zizith Cervantes-Yañez, Claudia Angélica Soto-Peredo, Gustavo Pastelín-Hernández, Leonardo Del Valle-Mondragón. The Role of the Activation of the TRPV1 Receptor and of Nitric Oxide in Changes in Endothelial and Cardiac Function and Biomarker Levels in Hypertensive Rats.
International journal of environmental research and public health.
2019 09; 16(19):. doi:
10.3390/ijerph16193576. [PMID: 31557799] - Yue Yin, Yawen Dong, Simon Vu, Fan Yang, Vladimir Yarov-Yarovoy, Yuhua Tian, Jie Zheng. Structural mechanisms underlying activation of TRPV1 channels by pungent compounds in gingers.
British journal of pharmacology.
2019 09; 176(17):3364-3377. doi:
10.1111/bph.14766. [PMID: 31207668] - Yawen Dong, Yue Yin, Simon Vu, Fan Yang, Vladimir Yarov-Yarovoy, Yuhua Tian, Jie Zheng. A distinct structural mechanism underlies TRPV1 activation by piperine.
Biochemical and biophysical research communications.
2019 08; 516(2):365-372. doi:
10.1016/j.bbrc.2019.06.039. [PMID: 31213294] - Mónika Kuzma, Krisztina Fodor, Attila Almási, Gyula Mózsik, Tibor Past, Pál Perjési. Toxicokinetic Study of a Gastroprotective Dose of Capsaicin by HPLC-FLD Method.
Molecules (Basel, Switzerland).
2019 Aug; 24(15):. doi:
10.3390/molecules24152848. [PMID: 31387338] - Alejandro Sánchez-Arreguin, Ramón Carriles, Neftalí Ochoa-Alejo, Mercedes G López, Lino Sánchez-Segura. Generation of BSA-capsaicin Nanoparticles and Their Hormesis Effect on the Rhodotorula mucilaginosa Yeast.
Molecules (Basel, Switzerland).
2019 Aug; 24(15):. doi:
10.3390/molecules24152800. [PMID: 31374810] - Padmamalini Baskaran, Laurel Markert, Jane Bennis, Liesl Zimmerman, Jonathan Fox, Baskaran Thyagarajan. Assessment of Pharmacology, Safety, and Metabolic activity of Capsaicin Feeding in Mice.
Scientific reports.
2019 06; 9(1):8588. doi:
10.1038/s41598-019-45050-0. [PMID: 31197191] - Leonardo G B Ferreira, Jessika P Prevatto, Hercules R Freitas, Ricardo A M Reis, Patrícia M R Silva, Marco A Martins, Robson X Faria, Vinicius F Carvalho. Capsaicin inhibits lipopolysaccharide-induced adrenal steroidogenesis by raising intracellular calcium levels.
Endocrine.
2019 04; 64(1):169-175. doi:
10.1007/s12020-019-01849-5. [PMID: 30729424] - Kenta Yamamura, Johsuke Hara, Noriyuki Ohkura, Miki Abo, Takashi Sone, Hideharu Kimura, Kazuo Kasahara. Increased Cough Receptor Sensitivity to Capsaicin Predicts a Positive Bronchial Thermoplasty Response: A Single-center Retrospective Study.
Journal of bronchology & interventional pulmonology.
2019 Apr; 26(2):137-141. doi:
10.1097/lbr.0000000000000577. [PMID: 30829895] - Jung Eun Kim, Yeong Ji Oh, Ah Young Song, Sea C Min. Preservation of red pepper flakes using microwave-combined cold plasma treatment.
Journal of the science of food and agriculture.
2019 Mar; 99(4):1577-1585. doi:
10.1002/jsfa.9336. [PMID: 30146707] - T A Nees, M Schiltenwolf. [Pharmacological treatment of osteoarthritis-related pain].
Schmerz (Berlin, Germany).
2019 Feb; 33(1):30-48. doi:
10.1007/s00482-018-0286-6. [PMID: 29644468] - Siyuan Yang, Lin Liu, Like Meng, Xuanyi Hu. Capsaicin is beneficial to hyperlipidemia, oxidative stress, endothelial dysfunction, and atherosclerosis in Guinea pigs fed on a high-fat diet.
Chemico-biological interactions.
2019 Jan; 297(?):1-7. doi:
10.1016/j.cbi.2018.10.006. [PMID: 30342015] - Sérgio Ricardo de Brito Bello, Katya Naliwaiko, Mariana Scudeller Vicentini, Francini Xavier Rossetti, Luiz Claudio Fernandes, Iara José de Messias-Reason. Nutrition and Cancercapsaicin Treatment Reduces Tumor Growth, Tumor Cell Proliferation Ex Vivo and Partially Reverses Cancer Cachexia in Walker 256 Tumor-Bearing Rats.
Nutrition and cancer.
2019; 71(1):111-117. doi:
10.1080/01635581.2018.1557219. [PMID: 30741012] - Mónica Ríos-Silva, Rubén Santos-Álvarez, Xóchitl Trujillo, Rosa Yolitzy Cárdenas-María, Marisa López-Zamudio, Jaime Alberto Bricio-Barrios, Caridad Leal, Alfredo Saavedra-Molina, Miguel Huerta-Trujillo, Karina Espinoza-Mejía, Miguel Huerta. Effects of Chronic Administration of Capsaicin on Biomarkers of Kidney Injury in Male Wistar Rats with Experimental Diabetes.
Molecules (Basel, Switzerland).
2018 Dec; 24(1):. doi:
10.3390/molecules24010036. [PMID: 30583465] - Ádám Horváth, Éva Borbély, Kata Bölcskei, Nikolett Szentes, Tamás Kiss, Mátyás Belák, Tibor Rauch, Tibor Glant, Róza Zákány, Tamás Juhász, Edina Karanyicz, Ferenc Boldizsár, Zsuzsanna Helyes, Bálint Botz. Regulatory role of capsaicin-sensitive peptidergic sensory nerves in the proteoglycan-induced autoimmune arthritis model of the mouse.
Journal of neuroinflammation.
2018 Dec; 15(1):335. doi:
10.1186/s12974-018-1364-5. [PMID: 30509328] - N I Yarushkina, M N Sudalina, Y M Punin, L P Filaretova. Vulnerability of gastric and small intestinal mucosa to ulcerogenic action of indomethacin in C57/BL6/J mice and transient receptor potential channel vanilloid type 1 knockout mice.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2018 Dec; 69(6):. doi:
10.26402/jpp.2018.6.09. [PMID: 30802217] - Guilherme B L De Freitas, Durinézio J De Almeida, Emerson Carraro, Ivo I Kerppers, Guilherme A G Martins, Rubiana M Mainardes, Najeh M Khalil, Iara J T Messias-Reason. Formulation, characterization, and in vitro/in vivo studies of capsaicin-loaded albumin nanoparticles.
Materials science & engineering. C, Materials for biological applications.
2018 Dec; 93(?):70-79. doi:
10.1016/j.msec.2018.07.064. [PMID: 30274103] - Shijie Zhang, Hui Liu, Qing Xu, Fei Huang, Ranran Xu, Qingquan Liu, Yongman Lv. Role of capsaicin sensitive sensory nerves in ischemia reperfusion-induced acute kidney injury in rats.
Biochemical and biophysical research communications.
2018 11; 506(1):176-182. doi:
10.1016/j.bbrc.2018.10.061. [PMID: 30342853] - Wang Siran, Chiara E Ghezzi, Dana M Cairns, Rachel E Pollard, Ying Chen, Rachel Gomes, Tina B McKay, Dimitra Pouli, Arsia Jamali, Irene Georgakoudi, James L Funderburgh, Kenneth Kenyon, Pedram Hamrah, David L Kaplan. Human Corneal Tissue Model for Nociceptive Assessments.
Advanced healthcare materials.
2018 10; 7(19):e1800488. doi:
10.1002/adhm.201800488. [PMID: 30091220] - Hong Zheng, Kenichi Katsurada, Xuefei Liu, Mark M Knuepfer, Kaushik P Patel. Specific Afferent Renal Denervation Prevents Reduction in Neuronal Nitric Oxide Synthase Within the Paraventricular Nucleus in Rats With Chronic Heart Failure.
Hypertension (Dallas, Tex. : 1979).
2018 09; 72(3):667-675. doi:
10.1161/hypertensionaha.118.11071. [PMID: 30012866] - Shuang-Quan Yu, Shuangtao Ma, Donna H Wang. Selective ablation of TRPV1 by intrathecal injection of resiniferatoxin in rats increases renal sympathoexcitatory responses and salt sensitivity.
Hypertension research : official journal of the Japanese Society of Hypertension.
2018 Sep; 41(9):679-690. doi:
10.1038/s41440-018-0073-x. [PMID: 30006640] - Otávio Augusto Chaves, Maurício Temotheo Tavares, Micael Rodrigues Cunha, Roberto Parise-Filho, Carlos Maurício R Sant'Anna, José Carlos Netto-Ferreira. Multi-Spectroscopic and Theoretical Analysis on the Interaction between Human Serum Albumin and a Capsaicin Derivative-RPF101.
Biomolecules.
2018 08; 8(3):. doi:
10.3390/biom8030078. [PMID: 30142945] - Ting Ren, Yuming You, Yuanli Luo, Yuanwei Wang, Xiong Liu. Hypocholesterolemic Effects of Capsaicinoids and Lactobacillus plantarum Swun5815 Combined by Inhibiting Cholesterol Synthesis and Increasing Bile Acid and Sterols Excretion on Ovariectomized Rats.
Journal of food science.
2018 Aug; 83(8):2247-2256. doi:
10.1111/1750-3841.14285. [PMID: 30059144] - Fan Yang, Xian Xiao, Bo Hyun Lee, Simon Vu, Wei Yang, Vladimir Yarov-Yarovoy, Jie Zheng. The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel.
Nature communications.
2018 07; 9(1):2879. doi:
10.1038/s41467-018-05339-6. [PMID: 30038260] - Milad Mohammadi, Beatrice Oehler, Jan Kloka, Corinna Martin, Alexander Brack, Robert Blum, Heike L Rittner. Antinociception by the anti-oxidized phospholipid antibody E06.
British journal of pharmacology.
2018 07; 175(14):2940-2955. doi:
10.1111/bph.14340. [PMID: 29679953] - Amritlal Mandal, Mohammad Shahidullah, Nicholas A Delamere. TRPV1-dependent ERK1/2 activation in porcine lens epithelium.
Experimental eye research.
2018 07; 172(?):128-136. doi:
10.1016/j.exer.2018.04.006. [PMID: 29654770] - Yalan Han, Bowen Li, Ting-Ting Yin, Cheng Xu, Rose Ombati, Lei Luo, Yujie Xia, Lizhen Xu, Jie Zheng, Yaping Zhang, Fan Yang, Guo-Dong Wang, Shilong Yang, Ren Lai. Molecular mechanism of the tree shrew's insensitivity to spiciness.
PLoS biology.
2018 07; 16(7):e2004921. doi:
10.1371/journal.pbio.2004921. [PMID: 30001322] - Taige Cao, Hong Liang Tey, Gil Yosipovitch. Chronic Pruritus in the Geriatric Population.
Dermatologic clinics.
2018 Jul; 36(3):199-211. doi:
10.1016/j.det.2018.02.004. [PMID: 29929593] - A Zak, N Siwinska, M Slowikowska, H Borowicz, P Szpot, M Zawadzki, A Niedzwiedz. The detection of capsaicin and dihydrocapsaicin in horse serum following long-term local administration.
BMC veterinary research.
2018 Jun; 14(1):193. doi:
10.1186/s12917-018-1518-9. [PMID: 29914499] - Arafat Nasser, Anette Torvin Møller, Vibe Hellmund, Sidsel Salling Thorborg, Cathrine Jespersgaard, Ole J Bjerrum, Erik Dupont, Gösta Nachman, Jens Lykkesfeldt, Troels Staehelin Jensen, Lisbeth Birk Møller. Heterozygous mutations in GTP-cyclohydrolase-1 reduce BH4 biosynthesis but not pain sensitivity.
Pain.
2018 Jun; 159(6):1012-1024. doi:
10.1097/j.pain.0000000000001175. [PMID: 29470312] - Julia Shanks, Zhiqiu Xia, Steven J Lisco, George J Rozanski, Harold D Schultz, Irving H Zucker, Han-Jun Wang. Sympatho-excitatory response to pulmonary chemosensitive spinal afferent activation in anesthetized, vagotomized rats.
Physiological reports.
2018 06; 6(12):e13742. doi:
10.14814/phy2.13742. [PMID: 29906340] - Renata Czekaj, Jolanta Majka, Katarzyna Magierowska, Zbigniew Sliwowski, Marcin Magierowski, Robert Pajdo, Agata Ptak-Belowska, Marcin Surmiak, Slawomir Kwiecien, Tomasz Brzozowski. Mechanisms of curcumin-induced gastroprotection against ethanol-induced gastric mucosal lesions.
Journal of gastroenterology.
2018 May; 53(5):618-630. doi:
10.1007/s00535-017-1385-3. [PMID: 28856444] - Prasarn Manitpisitkul, Christopher M Flores, John A Moyer, Gary Romano, Kevin Shalayda, Kanaka Tatikola, James S Hutchison, Arthur J Mayorga. A multiple-dose double-blind randomized study to evaluate the safety, pharmacokinetics, pharmacodynamics and analgesic efficacy of the TRPV1 antagonist JNJ-39439335 (mavatrep).
Scandinavian journal of pain.
2018 04; 18(2):151-164. doi:
10.1515/sjpain-2017-0184. [PMID: 29794306] - Meghana Koneru, Bidya Dhar Sahu, Salma Mukhtar Mir, Halley Gora Ravuri, Madhusudana Kuncha, Jerald Mahesh Kumar, Eswar Kumar Kilari, Ramakrishna Sistla. Capsaicin, the pungent principle of peppers, ameliorates alcohol-induced acute liver injury in mice via modulation of matrix metalloproteinases.
Canadian journal of physiology and pharmacology.
2018 Apr; 96(4):419-427. doi:
10.1139/cjpp-2017-0473. [PMID: 29053935] - Miguel Ortíz-Rentería, Rebeca Juárez-Contreras, Ricardo González-Ramírez, León D Islas, Félix Sierra-Ramírez, Itzel Llorente, Sidney A Simon, Marcia Hiriart, Tamara Rosenbaum, Sara L Morales-Lázaro. TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain.
Proceedings of the National Academy of Sciences of the United States of America.
2018 02; 115(7):E1657-E1666. doi:
10.1073/pnas.1715972115. [PMID: 29378958] - Tae Hwan Kim, Soyoung Shin, Sun Dong Yoo, Beom Soo Shin. Effects of Phytochemical P-Glycoprotein Modulators on the Pharmacokinetics and Tissue Distribution of Doxorubicin in Mice.
Molecules (Basel, Switzerland).
2018 Feb; 23(2):. doi:
10.3390/molecules23020349. [PMID: 29414892] - Yusuke Kanda, Youhei Yamasaki, Yoshie Sasaki-Yamaguchi, Noriko Ida-Koga, Shinji Kamisuki, Fumio Sugawara, Yoko Nagumo, Takeo Usui. TRPA1-dependent reversible opening of tight junction by natural compounds with an α,β-unsaturated moiety and capsaicin.
Scientific reports.
2018 02; 8(1):2251. doi:
10.1038/s41598-018-20526-7. [PMID: 29396565] - Ravindra M Satpute, Pramod K Kushwaha, D P Nagar, P V L Rao. Comparative safety evaluation of riot control agents of synthetic and natural origin.
Inhalation toxicology.
2018 02; 30(2):89-97. doi:
10.1080/08958378.2018.1451575. [PMID: 29595092] - Venu Perla, Marjan Nadimi, Rishi Reddy, Gerald R Hankins, Padma Nimmakayala, Robert T Harris, Jagan Valluri, Cristian Sirbu, Umesh K Reddy. Effect of ghost pepper on cell proliferation, apoptosis, senescence and global proteomic profile in human renal adenocarcinoma cells.
PloS one.
2018; 13(10):e0206183. doi:
10.1371/journal.pone.0206183. [PMID: 30379886] - Shuang-Quan Yu, Shuangtao Ma, Donna H Wang. Activation of TRPV1 Prevents Salt-Induced Kidney Damage and Hypertension After Renal Ischemia-Reperfusion Injury in Rats.
Kidney & blood pressure research.
2018; 43(4):1285-1296. doi:
10.1159/000492412. [PMID: 30078015] - Dokyoung S You, Rachel Haney, Sergiu Albu, Mary W Meagher. Generalized Pain Sensitization and Endogenous Oxytocin in Individuals With Symptoms of Migraine: A Cross-Sectional Study.
Headache.
2018 Jan; 58(1):62-77. doi:
10.1111/head.13213. [PMID: 29094347] - Y Takayama, Makoto Tominaga. Involvement of TRPV1-ANO1 Interactions in Pain-Enhancing Mechanisms.
Advances in experimental medicine and biology.
2018 ; 1099(?):29-36. doi:
10.1007/978-981-13-1756-9_3. [PMID: 30306512] - Rebecca E Yarwood, Wendy L Imlach, TinaMarie Lieu, Nicholas A Veldhuis, Dane D Jensen, Carmen Klein Herenbrink, Luigi Aurelio, Zhijian Cai, MacDonald J Christie, Daniel P Poole, Christopher J H Porter, Peter McLean, Gareth A Hicks, Pierangelo Geppetti, Michelle L Halls, Meritxell Canals, Nigel W Bunnett. Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission.
Proceedings of the National Academy of Sciences of the United States of America.
2017 11; 114(46):12309-12314. doi:
10.1073/pnas.1706656114. [PMID: 29087309]
