Kaempferol_3-O-rutinoside (BioDeep_00000000170)

 

Secondary id: BioDeep_00000398267

human metabolite PANOMIX_OTCML-2023 PANOMIX-Anthocyanidin


代谢物信息卡片


5,7-Dihydroxy-2-(4-hydroxyphenyl)-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one

化学式: C27H30O15 (594.1585)
中文名称: 山奈酚-3-O-芸香糖苷, 莰菲醇-3-O-芸香糖苷, 山柰素-3-O-芸香糖苷
谱图信息: 最多检出来源 Viridiplantae(plant) 28.48%

分子结构信息

SMILES: C1(O)=CC2OC(C3C=CC(O)=CC=3)=C(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]4[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O4)O3)C(=O)C=2C(O)=C1
InChI: InChI=1S/C27H30O15/c1-9-17(31)20(34)22(36)26(39-9)38-8-15-18(32)21(35)23(37)27(41-15)42-25-19(33)16-13(30)6-12(29)7-14(16)40-24(25)10-2-4-11(28)5-3-10/h2-7,9,15,17-18,20-23,26-32,34-37H,8H2,1H3/t9-,15+,17-,18+,20+,21-,22+,23+,26+,27-/m0/s1

描述信息

Kaempferol-3-rutinoside is a kaempferol O-glucoside that is kaempferol attached to a rutinosyl [6-deoxy-alpha-L-mannosyl-(1->6)-beta-D-glucosyl] residue at position 3 via a glycosidic linkage. It has been isolated from the leaves of Solanum campaniforme. It has a role as a metabolite, a radical scavenger and a plant metabolite. It is a rutinoside, a trihydroxyflavone, a disaccharide derivative and a kaempferol O-glucoside.
Nicotiflorin is a natural product found in Visnea mocanera, Eupatorium cannabinum, and other organisms with data available.
See also: Cocoa (part of).
A kaempferol O-glucoside that is kaempferol attached to a rutinosyl [6-deoxy-alpha-L-mannosyl-(1->6)-beta-D-glucosyl] residue at position 3 via a glycosidic linkage. It has been isolated from the leaves of Solanum campaniforme.
Nicotiflorin is a flavonoid glycoside extracted from a traditional Chinese medicine Carthamus tinctorius. Nicotiflorin shows potent antiglycation activity and neuroprotection effects.
Nicotiflorin is a flavonoid glycoside extracted from a traditional Chinese medicine Carthamus tinctorius. Nicotiflorin shows potent antiglycation activity and neuroprotection effects.

同义名列表

42 个代谢物同义名

5,7-Dihydroxy-2-(4-hydroxyphenyl)-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one; 5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxymethyl]tetrahydropyran-2-yl]oxy-chromen-4-one; 5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one; 4H-1-BENZOPYRAN-4-ONE, 3-((6-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)-.BETA.-D-GLUCOPYRANOSYL)OXY)-5,7-DIHYDROXY-2-(4-HYDROXYPHENYL)-; 4H-1-Benzopyran-4-one, 3-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-; 3-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one,3-[[6-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-3-yl 6-O-(6-deoxyhexopyranosyl)hexopyranoside; KAEMPFEROL 3-O-(.ALPHA.-L-RHAMNOPYRANOSYL-(1->6)-.BETA.-D-GLUCOPYRANOSIDE); KAEMPFEROL 3-O-.BETA.-D-(6-O-.ALPHA.-L-RHAMNOPYRANOSYL)GLUCOPYRANOSIDE; kaempferol-3-O-alpha-L-rhamanopyranosyl-(1-6)-beta-D-glucopyranoside; kaempferol 3-O-(6-O-alpha-L-rhamnopyranosyl)-beta-D-glucopyranoside; KAEMPFEROL 3-O-.ALPHA.-L-RHAMNOPYRANOSYL-.BETA.-D-GLUCOPYRANOSIDE; KAEMPFEROL-3-O-RUTINOSIDE (CONSTITUENT OF GINKGO) [DSC]; kaempferol-3-O-rhamanopyranosyl-(1-6)-glucopyranoside; Flavone, 3,4,5,7-tetrahydroxy-, 3-rhamnoglucoside; KAEMPFEROL-3-O-RUTINOSIDE (CONSTITUENT OF GINKGO); Kaempferol 3-O-beta -rutinoside, >=98.0\\% (HPLC); KAEMPFEROL 3-O-.BETA.-D-RUTINOSIDE; KAEMPFEROL 3-O-.BETA.-RUTINOSIDE; KAEMPFEROL 3-O-beta-D-RUTINOSIDE; Kaempferol 3-O-beta-rutinoside; KAEMPFEROL 3-.BETA.-RUTINOSIDE; Kaempferol-3-O-beta-rutinoside; Kaempferol 3-rhamno-glucoside; KAEMPFEROL 3-RHAMNOGLUCOSIDE; KAEMPFEROL 3-beta-RUTINOSIDE; RTATXGUCZHCSNG-QHWHWDPRSA-N; Kaempferol-3-O-rutinoside; Kaempferol 3-O-rutinoside; Kaempferol 3-Rutinoside; Kaempferol-3-rutinoside; Kaempferol 3-O-rutinose; 3-rutinosylkaempferol; NICTOFLORIN [INCI]; NICOTIFLOROSIDE; MEGxp0_000024; Nicotiflorine; nicotiflorin; ACon1_002178; Nictoflorin



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

308 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 ADIG, AKT1, BCL2, CASP3, CAT, JAK2, MTOR, NFE2L2, NLRP3, PTGS2, SIRT1, STAT3, VEGFA, XDH
Peripheral membrane protein 5 ACHE, GORASP1, JAK2, MTOR, PTGS2
Endoplasmic reticulum membrane 3 BCL2, MTOR, PTGS2
Nucleus 12 ACHE, ADIG, AKT1, BCL2, CASP3, JAK2, MTOR, NFE2L2, NLRP3, SIRT1, STAT3, VEGFA
cytosol 11 AKT1, BCL2, CASP3, CAT, JAK2, MTOR, NFE2L2, NLRP3, SIRT1, STAT3, XDH
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
centrosome 1 NFE2L2
nucleoplasm 7 AKT1, CASP3, JAK2, MTOR, NFE2L2, SIRT1, STAT3
RNA polymerase II transcription regulator complex 2 NFE2L2, STAT3
Cell membrane 3 ACHE, AKT1, TNF
Cytoplasmic side 2 GORASP1, MTOR
lamellipodium 1 AKT1
Golgi apparatus membrane 3 GORASP1, MTOR, NLRP3
Synapse 1 ACHE
cell cortex 1 AKT1
cell surface 3 ACHE, TNF, VEGFA
glutamatergic synapse 3 AKT1, CASP3, JAK2
Golgi apparatus 4 ACHE, GORASP1, NFE2L2, VEGFA
Golgi membrane 4 GORASP1, INS, MTOR, NLRP3
lysosomal membrane 2 GAA, MTOR
neuromuscular junction 1 ACHE
neuronal cell body 2 CASP3, TNF
postsynapse 2 AKT1, JAK2
Cytoplasm, cytosol 2 NFE2L2, NLRP3
Lysosome 2 GAA, MTOR
plasma membrane 7 ACHE, AKT1, GAA, JAK2, NFE2L2, STAT3, TNF
Membrane 10 ACHE, ADIG, AKT1, BCL2, CAT, GAA, JAK2, MTOR, NLRP3, VEGFA
caveola 2 JAK2, PTGS2
extracellular exosome 2 CAT, GAA
Lysosome membrane 2 GAA, MTOR
endoplasmic reticulum 4 BCL2, NLRP3, PTGS2, VEGFA
extracellular space 6 ACHE, IL6, INS, TNF, VEGFA, XDH
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 1 ACHE
adherens junction 1 VEGFA
mitochondrion 4 BCL2, CAT, NLRP3, SIRT1
protein-containing complex 4 AKT1, BCL2, CAT, PTGS2
intracellular membrane-bounded organelle 2 CAT, GAA
Microsome membrane 2 MTOR, PTGS2
postsynaptic density 1 CASP3
chromatin silencing complex 1 SIRT1
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 7 ACHE, ADIG, GAA, IL6, INS, NLRP3, VEGFA
extracellular region 9 ACHE, ADIG, CAT, GAA, IL6, INS, NLRP3, TNF, VEGFA
cytoplasmic side of plasma membrane 1 JAK2
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 2 ADIG, BCL2
mitochondrial outer membrane 2 BCL2, MTOR
mitochondrial matrix 1 CAT
Extracellular side 1 ACHE
transcription regulator complex 1 STAT3
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
microtubule cytoskeleton 1 AKT1
nucleolus 1 SIRT1
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
heterochromatin 1 SIRT1
Membrane raft 2 JAK2, TNF
pore complex 1 BCL2
focal adhesion 2 CAT, JAK2
spindle 1 AKT1
cis-Golgi network 1 GORASP1
extracellular matrix 1 VEGFA
Peroxisome 2 CAT, XDH
basement membrane 1 ACHE
sarcoplasmic reticulum 1 XDH
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 2 MTOR, SIRT1
PML body 2 MTOR, SIRT1
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 1 VEGFA
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 2 PTGS2, SIRT1
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 3 NFE2L2, SIRT1, STAT3
mediator complex 1 NFE2L2
phagocytic cup 1 TNF
cytoskeleton 1 JAK2
Lipid-anchor, GPI-anchor 1 ACHE
fibrillar center 1 SIRT1
nuclear envelope 2 MTOR, SIRT1
Endomembrane system 3 JAK2, MTOR, NLRP3
endosome lumen 2 INS, JAK2
Lipid droplet 1 ADIG
microtubule organizing center 1 NLRP3
tertiary granule membrane 1 GAA
euchromatin 2 JAK2, SIRT1
side of membrane 1 ACHE
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 IL6, INS, PTGS2
platelet alpha granule lumen 1 VEGFA
transport vesicle 1 INS
azurophil granule membrane 1 GAA
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 GORASP1, INS
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
extrinsic component of cytoplasmic side of plasma membrane 1 JAK2
synaptic cleft 1 ACHE
protein-DNA complex 1 NFE2L2
ficolin-1-rich granule membrane 1 GAA
death-inducing signaling complex 1 CASP3
eNoSc complex 1 SIRT1
rDNA heterochromatin 1 SIRT1
Cytoplasmic vesicle, phagosome 1 MTOR
extrinsic component of plasma membrane 1 JAK2
granulocyte macrophage colony-stimulating factor receptor complex 1 JAK2
interleukin-12 receptor complex 1 JAK2
interleukin-23 receptor complex 1 JAK2
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
autolysosome lumen 1 GAA
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Isoform H]: Cell membrane 1 ACHE
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[SirtT1 75 kDa fragment]: Cytoplasm 1 SIRT1


文献列表

  • Kendal Erdem Duman, Abdulahad Dogan, Burak Kaptaner. Ameliorative role of Cyanus depressus (M.Bieb.) Soják plant extract against diabetes-associated oxidative-stress-induced liver, kidney, and pancreas damage in rats. Journal of food biochemistry. 2022 10; 46(10):e14314. doi: 10.1111/jfbc.14314. [PMID: 35802765]
  • Seeseei Molimau-Samasoni, Victoria Helen Woolner, Su'emalo Talie Foliga, Katharina Robichon, Vimal Patel, Sarah K Andreassend, Jeffrey P Sheridan, Tama Te Kawa, David Gresham, Darach Miller, Daniel J Sinclair, Anne C La Flamme, Alexey V Melnik, Allegra Aron, Pieter C Dorrestein, Paul H Atkinson, Robert A Keyzers, Andrew B Munkacsi. Functional genomics and metabolomics advance the ethnobotany of the Samoan traditional medicine 'matalafi'. Proceedings of the National Academy of Sciences of the United States of America. 2021 11; 118(45):. doi: 10.1073/pnas.2100880118. [PMID: 34725148]
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  • Lin Wang, Chenyu Li, Chen Guan, Yue Zhang, Chengyu Yang, Long Zhao, Hong Luan, Bin Zhou, Lin Che, Yanfei Wang, Wei Zhang, Hui Zhang, Xiaofei Man, Wei Jiang, Yan Xu. Nicotiflorin attenuates cell apoptosis in renal ischemia-reperfusion injury through activating transcription factor 3. Nephrology (Carlton, Vic.). 2021 Apr; 26(4):358-368. doi: 10.1111/nep.13841. [PMID: 33295061]
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  • Shangshang Yu, Qi Guo, Tianqian Jia, Xiaofei Zhang, Dongyan Guo, Yanzhuo Jia, Jia Li, Jing Sun. Mechanism of Action of Nicotiflorin from Tricyrtis maculata in the Treatment of Acute Myocardial Infarction: From Network Pharmacology to Experimental Pharmacology. Drug design, development and therapy. 2021; 15(?):2179-2191. doi: 10.2147/dddt.s302617. [PMID: 34079221]
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  • Widad Ben Bakrim, Laila El Bouzidi, Jean-Marc Nuzillard, Sylvian Cretton, Noémie Saraux, Aymeric Monteillier, Philippe Christen, Muriel Cuendet, Khalid Bekkouche. Bioactive metabolites from the leaves of Withania adpressa. Pharmaceutical biology. 2018 Dec; 56(1):505-510. doi: 10.1080/13880209.2018.1499781. [PMID: 30451050]
  • Neslihan Turgut Kara, Özgür Çakır, Burcu Arıkan, Şule Arı. Molecular cloning and biotic elicitation response of phenylalanine ammonia-lyase gene of Astragalus chrysochlorus. Cellular and molecular biology (Noisy-le-Grand, France). 2018 Apr; 64(5):102-106. doi: . [PMID: 29729701]
  • Rudi Hendra, Paul A Keller. Phytochemical Studies on Two Australian Anigozanthos Plant Species. Journal of natural products. 2017 07; 80(7):2141-2145. doi: 10.1021/acs.jnatprod.7b00063. [PMID: 28682615]
  • Jun Zhao, Shilei Zhang, Shuping You, Tao Liu, Fang Xu, Tengfei Ji, Zhengyi Gu. Hepatoprotective Effects of Nicotiflorin from Nymphaea candida against Concanavalin A-Induced and D-Galactosamine-Induced Liver Injury in Mice. International journal of molecular sciences. 2017 Mar; 18(3):. doi: 10.3390/ijms18030587. [PMID: 28282879]
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  • Ning Li, Ying Wang, Xuezheng Li, Hong Zhang, Di Zhou, Wenli Wang, Wei Li, Xiangrong Zhang, Xinyu Li, Yue Hou, Dali Meng. Bioactive phenols as potential neuroinflammation inhibitors from the leaves of Xanthoceras sorbifolia Bunge. Bioorganic & medicinal chemistry letters. 2016 10; 26(20):5018-5023. doi: 10.1016/j.bmcl.2016.08.094. [PMID: 27623545]
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