4-Nitroquinoline N-oxide (BioDeep_00000001658)

 

Secondary id: BioDeep_00000406304

human metabolite blood metabolite


代谢物信息卡片


4-nitro-1λ⁵-quinolin-1-one

化学式: C9H6N2O3 (190.0378406)
中文名称: 4-硝基喹啉-N-氧化物
谱图信息: 最多检出来源 Homo sapiens(blood) 0.42%

分子结构信息

SMILES: C1=CC=C2C(=C1)C(=CC=[N+]2[O-])[N+](=O)[O-]
InChI: InChI=1S/C9H6N2O3/c12-10-6-5-9(11(13)14)7-3-1-2-4-8(7)10/h1-6H

描述信息

CONFIDENCE standard compound; INTERNAL_ID 2518
CONFIDENCE standard compound; INTERNAL_ID 8294
CONFIDENCE standard compound; INTERNAL_ID 37
D009676 - Noxae > D002273 - Carcinogens
D009676 - Noxae > D009153 - Mutagens

同义名列表

10 个代谢物同义名

4-nitro-1λ⁵-quinolin-1-one; 4-Nitroquinoline-1-oxide; 4-Nitroquinoline-N-oxide; 4 Nitroquinoline N oxide; 4-Nitroquinoline 1-oxide; 4-Nitroquinoline N-oxide; 4 Nitroquinoline 1 oxide; Nitrochin; 4-Nitroquinoline N-oxide; 4-Nitroquinoline-1-oxide



数据库引用编号

28 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Maria Alonso-Jauregui, Elena González-Peñas, Adela López de Cerain, Ariane Vettorazzi. Genotoxicity of 12 Mycotoxins by the SOS/umu Test: Comparison of Liver and Kidney S9 Fraction. Toxins. 2022 06; 14(6):. doi: 10.3390/toxins14060400. [PMID: 35737061]
  • Yuanyuan Li, Yanting Wang, Jie Li, Zihang Ling, Wei Chen, Liping Zhang, Qinchao Hu, Tong Wu, Bin Cheng, Yun Wang, Juan Xia. Tacrolimus inhibits oral carcinogenesis through cell cycle control. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Jul; 139(?):111545. doi: 10.1016/j.biopha.2021.111545. [PMID: 33873145]
  • Yanlin Jian, He Eun Forbes, Fabian Hulpia, Martijn D P Risseeuw, Guy Caljon, Hélène Munier-Lehmann, Helena I M Boshoff, Serge Van Calenbergh. 2-((3,5-Dinitrobenzyl)thio)quinazolinones: Potent Antimycobacterial Agents Activated by Deazaflavin (F420)-Dependent Nitroreductase (Ddn). Journal of medicinal chemistry. 2021 01; 64(1):440-457. doi: 10.1021/acs.jmedchem.0c01374. [PMID: 33347317]
  • Aparajita Verma, Vui King Vincent-Chong, Hendrik DeJong, Pamela A Hershberger, Mukund Seshadri. Impact of dietary vitamin D on initiation and progression of oral cancer. The Journal of steroid biochemistry and molecular biology. 2020 05; 199(?):105603. doi: 10.1016/j.jsbmb.2020.105603. [PMID: 31981799]
  • Grace Gar-Lee Yue, Lin Li, Julia Kin-Ming Lee, Hin-Fai Kwok, Eric Chun-Wai Wong, Mingyue Li, Kwok-Pui Fung, Jun Yu, Anthony Wing-Hung Chan, Philip Wai-Yan Chiu, Clara Bik-San Lau. Multiple modulatory activities of Andrographis paniculata on immune responses and xenograft growth in esophageal cancer preclinical models. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Jul; 60(?):152886. doi: 10.1016/j.phymed.2019.152886. [PMID: 30910259]
  • Nashwan Al-Afifi, Aied Alabsi, Fahmi Kaid, Marina Bakri, Anand Ramanathan. Prevention of oral carcinogenesis in rats by Dracaena cinnabari resin extracts. Clinical oral investigations. 2019 May; 23(5):2287-2301. doi: 10.1007/s00784-018-2685-6. [PMID: 30291495]
  • Maria Laura Pati, Paola Vitale, Savina Ferorelli, Mariaclara Iaselli, Morena Miciaccia, Angelina Boccarelli, Giuseppe Davide Di Mauro, Cosimo G Fortuna, Thaisa Francielle Souza Domingos, Luiz Cláudio Rodrigues Pereira da Silva, Marcelo de Pádula, Lucio Mendes Cabral, Plínio Cunha Sathler, Angelo Vacca, Antonio Scilimati, Maria Grazia Perrone. Translational impact of novel widely pharmacological characterized mofezolac-derived COX-1 inhibitors combined with bortezomib on human multiple myeloma cell lines viability. European journal of medicinal chemistry. 2019 Feb; 164(?):59-76. doi: 10.1016/j.ejmech.2018.12.029. [PMID: 30590258]
  • Carolina Foot Gomes DE Moura, Glaucia Resende Soares, Flavia Andressa Pidone Ribeiro, Marcelo Jose Dias Silva, Wagner Vilegas, Aline Boveto Santamarina, Luciana Pellegrini Pisani, Debora Estadella, Daniel Araki Ribeiro. Evaluation of the Chemopreventive Activity of Grape Skin Extract Using Medium-term Oral Carcinogenesis Assay Induced by 4-Nitroquinoline 1-Oxide. Anticancer research. 2019 Jan; 39(1):177-182. doi: 10.21873/anticanres.13095. [PMID: 30591456]
  • Lianmei Zhao, Ming Ma, Hao Wu, Cong Zhang, Suli Dai, Pei Dong, Bingjie Huo, Baoen Shan. p-Hydroxylcinnamaldehyde slows the progression of 4NQO-induced oesophageal tumourigenesis via the RhoA-MAPK signaling pathway. Molecular carcinogenesis. 2018 10; 57(10):1319-1331. doi: 10.1002/mc.22847. [PMID: 29873419]
  • Mark E Hamilton, Niels C Bols, Bernard P Duncker. The characterization of γH2AX and p53 as biomarkers of genotoxic stress in a rainbow trout (Oncorhynchus mykiss) brain cell line. Chemosphere. 2018 Jun; 201(?):850-858. doi: 10.1016/j.chemosphere.2018.03.015. [PMID: 29554631]
  • C C Carneiro, J Holanda Véras, B R Lima Góes, C N Pérez, L Chen-Chen. Mutagenicity and antimutagenicity of Salacia crassifolia (mart. Ex. Schult.) G. Don. evaluated by Ames test. Brazilian journal of biology = Revista brasleira de biologia. 2018 May; 78(2):345-350. doi: 10.1590/1519-6984.166593. [PMID: 28954013]
  • Subhayan Sur, Robert Steele, Rajeev Aurora, Mark Varvares, Katherine E Schwetye, Ratna B Ray. Bitter Melon Prevents the Development of 4-NQO-Induced Oral Squamous Cell Carcinoma in an Immunocompetent Mouse Model by Modulating Immune Signaling. Cancer prevention research (Philadelphia, Pa.). 2018 04; 11(4):191-202. doi: 10.1158/1940-6207.capr-17-0237. [PMID: 29061560]
  • Glaucia Resende Soares, Carolina Foot Gomes de Moura, Marcelo Jose Dias Silva, Wagner Vilegas, Aline Boveto Santamarina, Luciana Pellegrini Pisani, Debora Estadella, Daniel Araki Ribeiro. Protective effects of purple carrot extract (Daucus carota) against rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide. Medical oncology (Northwood, London, England). 2018 Mar; 35(4):54. doi: 10.1007/s12032-018-1114-7. [PMID: 29546679]
  • Shalini Mohan, Kalaivani Thiagarajan, Rajasekaran Chandrasekaran. Evaluation of ethyl gallate for its antioxidant and anticancer properties against chemical-induced tongue carcinogenesis in mice. The Biochemical journal. 2017 08; 474(17):3011-3025. doi: 10.1042/bcj20170316. [PMID: 28679629]
  • Zhongjian Xie, Yuan Yuan, Yi Jiang, Chandrama Shrestha, Ying Chen, Liyan Liao, Shangli Ji, Xiaoge Deng, Eryuan Liao, Daniel D Bikle. p120-Catenin Is Required for Dietary Calcium Suppression of Oral Carcinogenesis in Mice. Journal of cellular physiology. 2017 Jun; 232(6):1360-1367. doi: 10.1002/jcp.25620. [PMID: 27682597]
  • Yu-Ching Liu, Heng-Chien Ho, Miau-Rong Lee, Chung-Min Yeh, Hsien-Chang Tseng, Yung-Chang Lin, Jing-Gung Chung. Cortactin is a prognostic marker for oral squamous cell carcinoma and its overexpression is involved in oral carcinogenesis. Environmental toxicology. 2017 Mar; 32(3):799-812. doi: 10.1002/tox.22280. [PMID: 27148699]
  • Cristiene Costa Carneiro, Aroldo Vieira de Moraes-Filho, Amanda Silva Fernandes, Suzana da Costa Santos, Daniela de Melo E Silva, Lee Chen Chen. Cytotoxic and Chemopreventive Effects of Gemin D Against Different Mutagens Using In Vitro and In Vivo Assays. Anti-cancer agents in medicinal chemistry. 2017; 17(5):712-718. doi: 10.2174/1871520616666160906092502. [PMID: 27600790]
  • Yoonhwa Jeong, Mina Jung, Myeung Ju Kim, Cheol Ho Hwang. A 4-Nitroquinoleneoxide-Induced Pleurotus eryngii Mutant Variety Increases Pin1 Expression in Rat Brain. Journal of medicinal food. 2017 Jan; 20(1):65-70. doi: 10.1089/jmf.2016.3809. [PMID: 28098518]
  • Elix Alberto Domínguez-Mendoza, Jorge Cornejo-Garrido, Eleuterio Burgueño-Tapia, Cynthia Ordaz-Pichardo. Antidiabetic effect, antioxidant activity, and toxicity of 3',4'-Di-O-acetyl-cis-khellactone in Streptozotocin-induced diabetic rats. Bioorganic & medicinal chemistry letters. 2016 08; 26(16):4086-91. doi: 10.1016/j.bmcl.2016.06.071. [PMID: 27397496]
  • Shalini Mohan, Kalaivani Thiagarajan, Balaji Sundaramoorthy, Vivek Gurung, Manas Barpande, Shilpi Agarwal, Rajasekaran Chandrasekaran. Alleviation of 4-nitroquinoline 1-oxide induced oxidative stress by Oroxylum indicum (L.) leaf extract in albino Wistar rats. BMC complementary and alternative medicine. 2016 Jul; 16(?):229. doi: 10.1186/s12906-016-1186-x. [PMID: 27430309]
  • Agata Skrzypczak, Natalia Przystupa, Anna Zgadzaj, Andrzej Parzonko, Katarzyna Sykłowska-Baranek, Katarzyna Paradowska, Grzegorz Nałęcz-Jawecki. Antigenotoxic, anti-photogenotoxic and antioxidant activities of natural naphthoquinone shikonin and acetylshikonin and Arnebia euchroma callus extracts evaluated by the umu-test and EPR method. Toxicology in vitro : an international journal published in association with BIBRA. 2015 Dec; 30(1 Pt B):364-72. doi: 10.1016/j.tiv.2015.09.029. [PMID: 26434532]
  • Marnie E Light, Roel Anthonissen, Annemarie Maes, Luc Verschaeve, Martin Pošta, Johannes Van Staden. Genotoxicity testing of 3,4,5-trimethylfuran-2(5H)-one, a compound from plant-derived smoke with germination inhibitory activity. Mutation research. Genetic toxicology and environmental mutagenesis. 2015 Jan; 778(?):1-5. doi: 10.1016/j.mrgentox.2014.12.006. [PMID: 25726142]
  • Yi Jiang, Liyan Liao, Chandrama Shrestha, Daiqiang Li, Meirong Li, Ying Mu, Debra Crumrine, Larry Wang, Zhongjian Xie. Inhibition of 4-nitroquinoline-1-oxide-induced oral carcinogenesis by dietary calcium. International journal of clinical and experimental pathology. 2015; 8(4):3529-42. doi: . [PMID: 26097536]
  • Flávia Andressa Pidone Ribeiro, Rogerio Correa Peres, Celina Tizuko Fujiyama Oshima, Luiz Carlos Spolidorio, Luciana Le Sueur Maluf, Daniel Araki Ribeiro. Antioxidant activity of apple extract protects against rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide. Toxicology mechanisms and methods. 2015; 25(7):532-7. doi: 10.3109/15376516.2015.1053651. [PMID: 26062009]
  • Mehran Mesgari Abbasi, Sanaz Helli, Amir Monfaredan, Rana Jahanban-Esfahlan. Hesa-A Improves Clinical Outcome of Oral Carcinoma by Affecting p53 Gene Expression in vivo. Asian Pacific journal of cancer prevention : APJCP. 2015; 16(10):4169-72. doi: 10.7314/apjcp.2015.16.10.4169. [PMID: 26028067]
  • Ana Rita Ribeiro Barcessat, Isaac Huang, Gustavo Davi Rabelo, Flávia Cristina Perillo Rosin, Luciana Gonçalves Valente Ferreira, João Gualberto de Cerqueira Luz, Luciana Corrêa. Systemic toxic effects during early phases of topical 4-NQO-induced oral carcinogenesis in rats. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 2014 Nov; 43(10):770-7. doi: 10.1111/jop.12190. [PMID: 24931357]
  • Damien J Downes, Mark Chonofsky, Kaeling Tan, Brandon T Pfannenstiel, Samara L Reck-Peterson, Richard B Todd. Characterization of the mutagenic spectrum of 4-nitroquinoline 1-oxide (4-NQO) in Aspergillus nidulans by whole genome sequencing. G3 (Bethesda, Md.). 2014 Oct; 4(12):2483-92. doi: 10.1534/g3.114.014712. [PMID: 25352541]
  • Flávia Andressa Pidone Ribeiro, Carolina Foot Gomes de Moura, Andrea Pitelli Boiago Gollucke, Mônica Siqueira Ferreira, Rodrigo Ramos Catharino, Odair Aguiar, Regina Celia Spadari, Luis Fernando Barbisan, Daniel Araki Ribeiro. Chemopreventive activity of apple extract following medium-term oral carcinogenesis assay induced by 4-nitroquinoline-1-oxide. Archives of oral biology. 2014 Aug; 59(8):815-21. doi: 10.1016/j.archoralbio.2014.04.013. [PMID: 24863658]
  • Mick D Fellows, Angela McDermott, Katie R Clare, Ann Doherty, Marilyn J Aardema. The spectral karyotype of L5178Y TK⁺/⁻ mouse lymphoma cells clone 3.7.2C and factors affecting mutant frequency at the thymidine kinase (tk) locus in the microtitre mouse lymphoma assay. Environmental and molecular mutagenesis. 2014 Jan; 55(1):35-42. doi: 10.1002/em.21819. [PMID: 24375635]
  • Hirohiko Suwa, Masato Hirano, Kouji Kawarada, Motohiko Nagayama, Michiko Ehara, Tomonari Muraki, Hayase Shisa, Aiko Sugiyama, Masahiro Sugimoto, Hiroshi Hiai, Motoo Kitano, Jun-Ichi Tanuma. Pthlh, a promising cancer modifier gene in rat tongue carcinogenesis. Oncology reports. 2014 Jan; 31(1):3-12. doi: 10.3892/or.2013.2859. [PMID: 24253735]
  • Yian Wang, Ruisheng Yao, Song Gao, Weidong Wen, Yinqiu Du, Eva Szabo, Ming Hu, Ronald A Lubet, Ming You. Chemopreventive effect of a mixture of Chinese Herbs (antitumor B) on chemically induced oral carcinogenesis. Molecular carcinogenesis. 2013 Jan; 52(1):49-56. doi: 10.1002/mc.20877. [PMID: 22086836]
  • I E Dueñas-García, L F Santos-Cruz, L Castañeda-Partida, A N Castañeda-Sortibrán, M G Ordaz-Téllez, A Sánchez-Santos, A Durán-Díaz, R Rodríguez-Arnaiz, M E Heres-Pulido. Interactions of sulforaphane and dimethyl sulfoxide with methyl methanesulfonate, urethane, 4-nitroquinoline-1-oxide and hydrogen peroxide in the Drosophila melanogaster wing spot test. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2012 Dec; 50(12):4479-86. doi: 10.1016/j.fct.2012.09.003. [PMID: 23026699]
  • Dimitris Avgoustidis, Themistoklis Nisyrios, Emeka Nkenke, Roger Lijnen, Vassilis Ragos, Despina Perrea, Ismini Donta, Apostolia Vaena, Christos Yapijakis, Eleftherios Vairaktaris. Oral carcinogenesis is not achieved in different carcinogen-treated PAI-1 transgenic and wild-type mouse models. In vivo (Athens, Greece). 2012 Nov; 26(6):1001-5. doi: . [PMID: 23160684]
  • Yu-Ching Liu, Heng-Chien Ho, Miau-Rong Lee, Kuang-Chi Lai, Chung-Min Yeh, Yueh-Min Lin, Tin-Yun Ho, Chien-Yun Hsiang, Jing-Gung Chung. Early induction of cytokines/cytokine receptors and Cox2, and activation of NF-κB in 4-nitroquinoline 1-oxide-induced murine oral cancer model. Toxicology and applied pharmacology. 2012 Jul; 262(2):107-16. doi: 10.1016/j.taap.2012.04.023. [PMID: 22561872]
  • Seo Young Bang, Jeong Hoon Kim, Phil Young Lee, Kwang-Hee Bae, Jong Suk Lee, Pan-Soo Kim, Do Hee Lee, Pyung Keun Myung, Byoung Chul Park, Sung Goo Park. Confirmation of Frm2 as a novel nitroreductase in Saccharomyces cerevisiae. Biochemical and biophysical research communications. 2012 Jul; 423(4):638-41. doi: 10.1016/j.bbrc.2012.05.156. [PMID: 22687599]
  • Ashok Kumar Pandurangan, Srinivasan Periasamy, Suresh Kumar Anandasadagopan, Sudhandiran Ganapasam, Shyamala Devi Chennam Srinivasalu. Green tea polyphenol protection against 4-nitroquinoline 1-oxide-induced bone marrow lipid peroxidation and genotoxicity in Wistar rats. Asian Pacific journal of cancer prevention : APJCP. 2012; 13(8):4107-12. doi: 10.7314/apjcp.2012.13.8.4107. [PMID: 23098525]
  • Masamitsu Shimazu, Teruhiro Itaya, Pongsanat Pongcharoen, Takayuki Sekito, Miyuki Kawano-Kawada, Yoshimi Kakinuma. Vba5p, a novel plasma membrane protein involved in amino acid uptake and drug sensitivity in Saccharomyces cerevisiae. Bioscience, biotechnology, and biochemistry. 2012; 76(10):1993-5. doi: 10.1271/bbb.120455. [PMID: 23047103]
  • Mohammed E Grawish, Manal M Zyada, Ahmed R Zaher. Inhibition of 4-NQO-induced F433 rat tongue carcinogenesis by oleuropein-rich extract. Medical oncology (Northwood, London, England). 2011 Dec; 28(4):1163-8. doi: 10.1007/s12032-010-9612-2. [PMID: 20596802]
  • Bojana Zegura, David Dobnik, Maša Hojnik Niderl, Metka Filipič. Antioxidant and antigenotoxic effects of rosemary (Rosmarinus officinalis L.) extracts in Salmonella typhimurium TA98 and HepG2 cells. Environmental toxicology and pharmacology. 2011 Sep; 32(2):296-305. doi: 10.1016/j.etap.2011.06.002. [PMID: 21843811]
  • C A Rivera, D A Droguett, U Kemmerling, B A Venegas. Chronic restraint stress in oral squamous cell carcinoma. Journal of dental research. 2011 Jun; 90(6):799-803. doi: 10.1177/0022034511399911. [PMID: 21393554]
  • Nai Wen Chang, Ming-Hsui Tsai, Chingju Lin, Hui Ting Hsu, Pei-Yi Chu, Chung-Min Yeh, Chang-Fang Chiu, Kun-Tu Yeh. Fenofibrate exhibits a high potential to suppress the formation of squamous cell carcinoma in an oral-specific 4-nitroquinoline 1-oxide/arecoline mouse model. Biochimica et biophysica acta. 2011 Apr; 1812(4):558-64. doi: 10.1016/j.bbadis.2010.11.002. [PMID: 21081159]
  • Robert L Brent, Mildred S Christian, Robert M Diener. Evaluation of the reproductive and developmental risks of caffeine. Birth defects research. Part B, Developmental and reproductive toxicology. 2011 Apr; 92(2):152-87. doi: 10.1002/bdrb.20288. [PMID: 21370398]
  • Ponnan Arumugam, Samiraj Ramesh. Protective effects of sesame oil on 4-NQO-induced oxidative DNA damage and lipid peroxidation in rats. Drug and chemical toxicology. 2011 Apr; 34(2):116-9. doi: 10.3109/01480541003782310. [PMID: 21314461]
  • Rebecca J Leeman-Neill, Raja R Seethala, Shivendra V Singh, Maria L Freilino, Joseph S Bednash, Sufi M Thomas, Mary C Panahandeh, William E Gooding, Sonali C Joyce, Mark W Lingen, Daniel B Neill, Jennifer R Grandis. Inhibition of EGFR-STAT3 signaling with erlotinib prevents carcinogenesis in a chemically-induced mouse model of oral squamous cell carcinoma. Cancer prevention research (Philadelphia, Pa.). 2011 Feb; 4(2):230-7. doi: 10.1158/1940-6207.capr-10-0249. [PMID: 21163936]
  • Vijaya Padma Viswanadha, Siddharth Sivan, Roopesh Rajendra Shenoi. Protective effect of Spirulina against 4-nitroquinoline-1-oxide induced toxicity. Molecular biology reports. 2011 Jan; 38(1):309-17. doi: 10.1007/s11033-010-0109-z. [PMID: 20352348]
  • Griselda Wilson-Sanchez, Carolina Moreno-Félix, Carlos Velazquez, Maribel Plascencia-Jatomea, Anita Acosta, Lorena Machi-Lara, María-Lourdes Aldana-Madrid, Josafat-Marina Ezquerra-Brauer, Ramón Robles-Zepeda, Armando Burgos-Hernandez. Antimutagenicity and antiproliferative studies of lipidic extracts from white shrimp (Litopenaeus vannamei). Marine drugs. 2010 Nov; 8(11):2795-809. doi: 10.3390/md8112795. [PMID: 21139845]
  • Natsuko Suwaki, Emma S Child, Lucy M Elphick, David J Mann. Dose-dependent changes in cyclin D1 in response to 4-nitroquinoline 1-oxide-induced DNA damage. Archives of biochemistry and biophysics. 2010 May; 497(1-2):55-61. doi: 10.1016/j.abb.2010.03.003. [PMID: 20214871]
  • Prabhjit Kaur, Madhu Chandel, Subodh Kumar, Neeraj Kumar, Bikram Singh, Satwinderjeet Kaur. Modulatory role of alizarin from Rubia cordifolia L. against genotoxicity of mutagens. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2010 Jan; 48(1):320-5. doi: 10.1016/j.fct.2009.10.019. [PMID: 19852997]
  • Sampath Kaleeswaran, Padmanabhan Sriram, Daivasigamani Prabhu, Lalgudi Narayanan Mathuram. Anti- and pro-mutagenic effects of silymarin in the Ames bacterial reverse mutation assay. Phytotherapy research : PTR. 2009 Oct; 23(10):1378-84. doi: 10.1002/ptr.2772. [PMID: 19277970]
  • C Pungartnik, S C O Melo, T S Basso, W G Macena, J C M Cascardo, M Brendel. Reactive oxygen species and autophagy play a role in survival and differentiation of the phytopathogen Moniliophthora perniciosa. Fungal genetics and biology : FG & B. 2009 Jun; 46(6-7):461-72. doi: 10.1016/j.fgb.2009.03.007. [PMID: 19324099]
  • J Demma, E Engidawork, B Hellman. Potential genotoxicity of plant extracts used in Ethiopian traditional medicine. Journal of ethnopharmacology. 2009 Feb; 122(1):136-42. doi: 10.1016/j.jep.2008.12.013. [PMID: 19146933]
  • Ponnan Arumugam, Arabandi Ramesh. Antigenotoxic and antioxidant potential of aqueous fraction of ethanol extract of Mentha spicata (L.) against 4-nitroquinoline-1-oxide-induced chromosome damage in mice. Drug and chemical toxicology. 2009; 32(4):411-6. doi: 10.1080/01480540903127316. [PMID: 19793034]
  • Ursula Schmid, Helga Stopper, August Heidland, Nicole Schupp. Benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage in vitro. Diabetes/metabolism research and reviews. 2008 Jul; 24(5):371-7. doi: 10.1002/dmrr.860. [PMID: 18384109]
  • R X Santos, S C O Melo, J C M Cascardo, M Brendel, C Pungartnik. Carbon source-dependent variation of acquired mutagen resistance of Moniliophthora perniciosa: similarities in natural and artificial systems. Fungal genetics and biology : FG & B. 2008 Jun; 45(6):851-60. doi: 10.1016/j.fgb.2008.02.005. [PMID: 18378474]
  • Periasamy Srinivasan, Subramaniyan Suchalatha, Pon Velayutham Anandh Babu, Rethinam Sundaresan Devi, Shoba Narayan, Kuruvimalai Ekambaram Sabitha, Chennam Srinivasulu Shyamala Devi. Chemopreventive and therapeutic modulation of green tea polyphenols on drug metabolizing enzymes in 4-Nitroquinoline 1-oxide induced oral cancer. Chemico-biological interactions. 2008 Apr; 172(3):224-34. doi: 10.1016/j.cbi.2008.01.010. [PMID: 18336807]
  • Javor Kac, Janja Plazar, Ales Mlinaric, Bojana Zegura, Tamara T Lah, Metka Filipic. Antimutagenicity of hops (Humulus lupulus L.): bioassay-directed fractionation and isolation of xanthohumol. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2008 Mar; 15(3):216-20. doi: 10.1016/j.phymed.2007.09.008. [PMID: 17959367]
  • E Miadokova, S Nadova, V Vlckova, V Duhova, M Kopaskova, L Cipak, P Rauko, P Mucaji, D Grancai. Antigenotoxic effect of extract from Cynara cardunculus L. Phytotherapy research : PTR. 2008 Jan; 22(1):77-81. doi: 10.1002/ptr.2268. [PMID: 17724772]
  • Yu-Hsiang Hung, Hui-Yu Huang, Cheng-Chun Chou. Mutagenic and antimutagenic effects of methanol extracts of unfermented and fermented black soybeans. International journal of food microbiology. 2007 Aug; 118(1):62-8. doi: 10.1016/j.ijfoodmicro.2007.06.005. [PMID: 17628128]
  • Canhua Jiang, Dongxia Ye, Weiliu Qiu, Xiuli Zhang, Zhiyuan Zhang, Di He, Ping Zhang, Wantao Chen. Response of lymphocyte subsets and cytokines to Shenyang prescription in Sprague-Dawley rats with tongue squamous cell carcinomas induced by 4NQO. BMC cancer. 2007 Mar; 7(?):40. doi: 10.1186/1471-2407-7-40. [PMID: 17338814]
  • Periasamy Srinivasan, Kuruvimalai Ekambaram Sabitha, Chennam Srinivasulu Shyamaladevi. Attenuation of 4-nitroquinoline 1-oxide induced in vitro lipid peroxidation by green tea polyphenols. Life sciences. 2007 Feb; 80(12):1080-6. doi: 10.1016/j.lfs.2006.11.051. [PMID: 17280688]
  • Yongdoo Choi, Sang Yoon Kim, Kyeongsoon Park, Jehoon Yang, Kyung-Ja Cho, Hyun Ja Kwon, Youngro Byun. Chemopreventive efficacy of all-trans-retinoic acid in biodegradable microspheres against epithelial cancers: results in a 4-nitroquinoline 1-oxide-induced oral carcinogenesis model. International journal of pharmaceutics. 2006 Aug; 320(1-2):45-52. doi: 10.1016/j.ijpharm.2006.04.003. [PMID: 16730144]
  • Periasamy Srinivasan, Kuruvimalai Ekambaram Sabitha, Chennam Srinivasulu Shyamaladevi. Modulatory efficacy of green tea polyphenols on glycoconjugates and immunological markers in 4-Nitroquinoline 1-oxide-induced oral carcinogenesis-A therapeutic approach. Chemico-biological interactions. 2006 Aug; 162(2):149-56. doi: 10.1016/j.cbi.2006.05.021. [PMID: 16859662]
  • Sharmistha Dutta Choudhury, Samita Basu. Interaction of 4-nitroquinoline-1-oxide with indole derivatives and some related biomolecules: a study with magnetic field. The journal of physical chemistry. B. 2006 May; 110(17):8850-5. doi: 10.1021/jp055971l. [PMID: 16640444]
  • Can-hua Jiang, Dong-xia Ye, Wan-tao Chen, Xiu-li Zhang, Zhi-yuan Zhang, Wei-liu Qiu. [Modulation of Chinese prescription Shenyang on Th1/Th2 cytokines in serum of SD rats with squamous cell carcinoma of the tongue]. Shanghai kou qiang yi xue = Shanghai journal of stomatology. 2005 Jun; 14(3):289-92. doi: NULL. [PMID: 15995779]
  • Kyeongsoon Park, Je Hoon Yang, Yongdoo Choi, Chulkyu Lee, Sang Yoon Kim, Youngro Byun. Chemoprevention of 4-NQO-induced oral carcinogenesis by co-administration of all-trans retinoic acid loaded microspheres and celecoxib. Journal of controlled release : official journal of the Controlled Release Society. 2005 May; 104(1):167-79. doi: 10.1016/j.jconrel.2005.01.013. [PMID: 15866343]
  • Periasamy Srinivasan, Kuruvimalai Ekambaram Sabitha, Chennam Srinivasulu Shyamaladevi. Therapeutic efficacy of green tea polyphenols on cellular thiols in 4-Nitroquinoline 1-oxide-induced oral carcinogenesis. Chemico-biological interactions. 2004 Oct; 149(2-3):81-7. doi: 10.1016/j.cbi.2004.06.006. [PMID: 15501430]
  • Jeanelle Boyer, Rui Hai Liu. Apple phytochemicals and their health benefits. Nutrition journal. 2004 May; 3(?):5. doi: 10.1186/1475-2891-3-5. [PMID: 15140261]
  • L Verschaeve, V Kestens, J L S Taylor, E E Elgorashi, A Maes, L Van Puyvelde, N De Kimpe, J Van Staden. Investigation of the antimutagenic effects of selected South African medicinal plant extracts. Toxicology in vitro : an international journal published in association with BIBRA. 2004 Feb; 18(1):29-35. doi: 10.1016/s0887-2333(03)00131-0. [PMID: 14630059]
  • Kazuhiko Yamamoto, Wakashi Kitayama, Ayumi Denda, Ayumu Morisaki, Hiroki Kuniyasu, Tadaaki Kirita. Inhibitory effects of selective cyclooxygenase-2 inhibitors, nimesulide and etodolac, on the development of squamous cell dysplasias and carcinomas of the tongue in rats initiated with 4-nitroquinoline 1-oxide. Cancer letters. 2003 Sep; 199(2):121-9. doi: 10.1016/s0304-3835(03)00382-3. [PMID: 12969784]
  • G D Zasukhina, I M Vasil'eva, A D Durnev, S P Gromov, O A Fedorova, M V Alfimov. Antimutagenic activity of crown-containing compounds. Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections. 2002 May; 384(?):257-9. doi: 10.1023/a:1016038112558. [PMID: 12134498]
  • G N L'vova, G D Zasukhina. [Modification of repair DNA synthesis in mutagen-treated human fibroblasts during adaptive response and the antimutagenic effect of garlic extract]. Genetika. 2002 Mar; 38(3):306-9. doi: ". [PMID: 11963557]
  • I M Vasil'eva, G D Zasukhina. [Comparison of the protective effect of garlic extract and cell defense during adaptive response]. Genetika. 2002 Mar; 38(3):422-5. doi: ". [PMID: 11963572]
  • V V Arkhipchuk, N N Garanko. A novel nucleolar biomarker in plant and animal cells for assessment of substance cytotoxicity. Environmental toxicology. 2002; 17(3):187-94. doi: 10.1002/tox.10056. [PMID: 12112626]
  • Rossana Pasquini, Giuseppina Scassellati-Sforzolini, Milena Villarini, Massimo Moretti, Massimiliano Marcarelli, Cristina Fatigoni, Satwinderjeet Kaur, Subodh Kumar, Iqbal Sing Grover. In vitro protective effects of Terminalia arjuna bark extracts against the 4-nitroquinoline-N-oxide genotoxicity. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. 2002; 21(1):33-44. doi: ". [PMID: 11934011]
  • S Balasenthil, C R Ramachandran, S Nagini. Prevention of 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis by garlic. Fitoterapia. 2001 Jun; 72(5):524-31. doi: 10.1016/s0367-326x(01)00262-3. [PMID: 11429247]
  • H Shiotani, A Denda, K Yamamoto, W Kitayama, T Endoh, Y Sasaki, N Tsutsumi, M Sugimura, Y Konishi. Increased expression of cyclooxygenase-2 protein in 4-nitroquinoline-1-oxide-induced rat tongue carcinomas and chemopreventive efficacy of a specific inhibitor, nimesulide. Cancer research. 2001 Feb; 61(4):1451-6. doi: NULL. [PMID: 11245450]
  • M Sakaguchi, M Miyazaki, T Kondo, T Tsuji, H Kouchi, M Namba. Identification of a phosphoprotein that is downregulated in immortalized human fibroblasts. Electrophoresis. 2001 Jan; 22(1):155-60. doi: 10.1002/1522-2683(200101)22:1<155::aid-elps155>3.0.co;2-l. [PMID: 11197166]
  • M Miyazawa, K Sakano, S Nakamura , H Kosaka. Antimutagenic activity of isoflavone from Pueraria lobata. Journal of agricultural and food chemistry. 2001 Jan; 49(1):336-41. doi: 10.1021/jf000255w. [PMID: 11170596]
  • H Kasai, S Fukada, Z Yamaizumi, S Sugie, H Mori. Action of chlorogenic acid in vegetables and fruits as an inhibitor of 8-hydroxydeoxyguanosine formation in vitro and in a rat carcinogenesis model. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2000 May; 38(5):467-71. doi: 10.1016/s0278-6915(00)00014-4. [PMID: 10762733]
  • M Nakajima, M Kikuchi, K Saeki, Y Miyata, M Terada, F Kishida, R Yamamoto, C Furihata, S W Dean. Mutagenicity of 4-nitroquinoline 1-oxide in the MutaMouse. Mutation research. 1999 Aug; 444(2):321-36. doi: 10.1016/s1383-5718(99)00105-9. [PMID: 10521672]
  • M Takasaki, H Tokuda, H Nishino, T Konoshima. Cancer chemopreventive agents (antitumor-promoters) from Ajuga decumbens. Journal of natural products. 1999 Jul; 62(7):972-5. doi: 10.1021/np990033w. [PMID: 10425119]
  • G Umbuzeiro-Valent, D A Roubicek, E M Haebisch. Mutagenic and antimutagenic evaluation of the juice of the leaves of Bryophyllum calycinum (Kalanchoe pinnata), a plant with antihistamine activity. Environmental and molecular mutagenesis. 1999; 33(4):325-7. doi: 10.1002/(sici)1098-2280(1999)33:4<325::aid-em10>3.0.co;2-e. [PMID: 10398381]
  • G Scassellati-Sforzolini, L M Villarini, L M Moretti, L M Marcarelli, R Pasquini, C Fatigoni, L S Kaur, S Kumar, I S Grover. Antigenotoxic properties of Terminalia arjuna bark extracts. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. 1999; 18(2):119-25. doi: ". [PMID: 15281223]
  • R Nakaune, K Adachi, O Nawata, M Tomiyama, K Akutsu, T Hibi. A novel ATP-binding cassette transporter involved in multidrug resistance in the phytopathogenic fungus Penicillium digitatum. Applied and environmental microbiology. 1998 Oct; 64(10):3983-8. doi: 10.1128/aem.64.10.3983-3988.1998. [PMID: 9758830]
  • M D Gray, L Wang, H Youssoufian, G M Martin, J Oshima. Werner helicase is localized to transcriptionally active nucleoli of cycling cells. Experimental cell research. 1998 Aug; 242(2):487-94. doi: 10.1006/excr.1998.4124. [PMID: 9683536]
  • G B Zavilgelsky, S K Abilev, V V Sukhodolets, S I Ahmad. Isolation and analysis of UV and radio-resistant bacteria from Chernobyl. Journal of photochemistry and photobiology. B, Biology. 1998 May; 43(2):152-7. doi: 10.1016/s1011-1344(98)00099-2. [PMID: 9679315]
  • Y Miura, H S Ozaki, T J Li, M Uemura, M Kitano. Experimental odontogenic cysts induced by in vitro 4-nitroquinoline 1-oxide (4NQO) treatment of F344 rat incisor tooth germs. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 1998 Feb; 27(2):53-8. doi: 10.1111/j.1600-0714.1998.tb02093.x. [PMID: 9526729]
  • C Kuenemann-Migeot, F Callais, I Momas, B Festy. Use of Salmonella typhimurium TA 98, YG 1024 and YG 1021 and deconjugating enzymes for evaluating the mutagenicity from smokers' urine. Mutation research. 1997 May; 390(3):283-91. doi: 10.1016/s1383-5718(97)00029-6. [PMID: 9186578]
  • G H Degen, M M Gerber, S Obrecht-Pflumio, G Dirheimer. Induction of micronuclei with ochratoxin A in ovine seminal vesicle cell cultures. Archives of toxicology. 1997; 71(6):365-71. doi: 10.1007/s002040050400. [PMID: 9195018]
  • T Kondo, K Mihara, Y Inoue, M Namba. Two-dimensional electrophoretic studies on down-regulated intracellular transferrin in human fibroblasts immortalized by treatment with either 4-nitroquinoline 1-oxide or 60Co gamma rays. Electrophoresis. 1996 Oct; 17(10):1638-42. doi: 10.1002/elps.1150171026. [PMID: 8957196]
  • G C Yen, P D Duh. Antimutagenic effect of methanolic extracts from peanut hulls. Bioscience, biotechnology, and biochemistry. 1996 Oct; 60(10):1698-700. doi: 10.1271/bbb.60.1698. [PMID: 8987671]
  • S W Chan, A M Rich, P C Reade. Induction by 4-nitroquinoline-1-oxide of oral epithelial dysplasia and neoplasia in scurvy-prone osteogenic disorder Shionogi (ODS) rats. Nutrition and cancer. 1996; 26(1):83-90. doi: 10.1080/01635589609514465. [PMID: 8844724]
  • T Yano, S Takahashi, T Ichikawa. Active oxygen generated in the process of carcinogen metabolism can induce oxidative damage in nuclei. Research communications in molecular pathology and pharmacology. 1995 Mar; 87(3):367-70. doi: ". [PMID: 7620830]
  • I E Bosselaers, P W Caessens, M A Van Boekel, G M Alink. Differential effects of milk proteins, BSA and soy protein on 4NQO- or MNNG-induced SCEs in V79 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1994 Oct; 32(10):905-9. doi: 10.1016/0278-6915(94)90088-4. [PMID: 7959445]
  • G Fronza, C Madzak, P Campomenosi, A Inga, R Iannone, A Abbondandolo, A Sarasin. Mutation spectrum of 4-nitroquinoline 1-oxide-damaged single-stranded shuttle vector DNA transfected into monkey cells. Mutation research. 1994 Jul; 308(2):117-25. doi: 10.1016/0027-5107(94)90146-5. [PMID: 7518038]
  • Z C Jin, J Qian. [Inhibitory effects of fifteen kinds of Chinese herbal drugs, vegetables and chemicals on SOS response]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. 1994 May; 28(3):147-50. doi: ". [PMID: 7842869]
  • J K Hongslo, C V Smith, G Brunborg, E J Søderlund, J A Holme. Genotoxicity of paracetamol in mice and rats. Mutagenesis. 1994 Mar; 9(2):93-100. doi: 10.1093/mutage/9.2.93. [PMID: 8201952]
  • T Yano, Y Obata, G Ishikawa, K Hagiwara, T Ichikawa. Effect of vitamin E on 4-nitroquinoline 1-oxide-induced lung tumorigenesis in mice. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition. 1994; 64(3):181-4. doi: NULL. [PMID: 7814232]
  • M Namba, M Iijima, T Kondo, I Jahan, K Mihara. Immortalization of normal human cells is a multistep process and a rate limiting step of neoplastic transformation of the cells. Human cell. 1993 Dec; 6(4):253-9. doi: NULL. [PMID: 8148305]