L-Aspartic acid (BioDeep_00000001362)
Secondary id: BioDeep_00000398115, BioDeep_00000398614
natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019
Metabolite Card
Formula: C4H7NO4 (133.0375062)
Chinese Names: DL-天门冬氨酸, L-天门冬氨酸, 天冬氨酸溶液, L-天冬氨酸, 天冬氨酸
Spectrum Hits:
Top Source Homo sapiens(blood) 0.01%
Last reviewed on 2024-06-29.
Cite this Page
L-Aspartic acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/l-aspartic_acid (retrieved
2024-11-06) (BioDeep RN: BioDeep_00000001362). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Molecular Structure
SMILES: C(C(C(=O)O)N)C(=O)O
InChI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)
Description
Aspartic acid (Asp), also known as L-aspartic acid or as aspartate, the name of its anion, is an alpha-amino acid. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon). Amino acids are organic compounds that contain amino (–NH2) and carboxyl (–COOH) functional groups, along with a side chain (R group) specific to each amino acid. L-aspartic acid is one of 20 proteinogenic amino acids, i.e., the amino acids used in the biosynthesis of proteins. Aspartic acid is found in all organisms ranging from bacteria to plants to animals. It is classified as an acidic, charged (at physiological pH), aliphatic amino acid. In humans, aspartic acid is a nonessential amino acid derived from glutamic acid by enzymes using vitamin B6. However, in the human body, aspartate is most frequently synthesized through the transamination of oxaloacetate. A non-essential amino acid is an amino acid that can be synthesized from central metabolic pathway intermediates in humans and is not required in the diet. As its name indicates, aspartic acid is the carboxylic acid analog of asparagine. The D-isomer of aspartic acid (D-aspartic acid) is one of two D-amino acids commonly found in mammals. Aspartic acid was first discovered in 1827 by Auguste-Arthur Plisson and Étienne Ossian Henry by hydrolysis of asparagine, which had been isolated from asparagus juice in 1806. Aspartate has many biochemical roles. It is a neurotransmitter, a metabolite in the urea cycle and it participates in gluconeogenesis. It carries reducing equivalents in the malate-aspartate shuttle, which utilizes the ready interconversion of aspartate and oxaloacetate, which is the oxidized (dehydrogenated) derivative of malic acid. Aspartate donates one nitrogen atom in the biosynthesis of inosine, the precursor to the purine bases which are key to DNA biosynthesis. In addition, aspartic acid acts as a hydrogen acceptor in a chain of ATP synthase. Aspartic acid is a major excitatory neurotransmitter, which is sometimes found to be increased in epileptic and stroke patients. It is decreased in depressed patients and in patients with brain atrophy. As a neurotransmitter, aspartic acid may provide resistance to fatigue and thus lead to endurance, although the evidence to support this idea is not strong (Wikipedia). Aspartic acid supplements are being evaluated. Five grams can raise blood levels. Magnesium and zinc may be natural inhibitors of some of the actions of aspartic acid. Aspartic acid, when chemically coupled with the amino acid D-phenylalanine, is a part of a natural sweetener, aspartame. This sweetener is an advance in artificial sweeteners, and is probably safe in normal doses to all except phenylketonurics. Aspartic acid may be a significant immunostimulant of the thymus and can protect against some of the damaging effects of radiation. Aspartic acid is found in higher abundance in: oysters, luncheon meats, sausage meat, wild game, sprouting seeds, oat flakes, avocado, asparagus, young sugarcane, and molasses from sugar beets.
[Spectral] L-Aspartate (exact mass = 133.03751) and Taurine (exact mass = 125.01466) and L-Asparagine (exact mass = 132.05349) were not completely separated on HPLC under the present analytical conditions as described in AC$XXX. Additionally some of the peaks in this data contains dimers and other unidentified ions.
[Spectral] L-Aspartate (exact mass = 133.03751) and L-Threonine (exact mass = 119.05824) were not completely separated on HPLC under the present analytical conditions as described in AC$XXX. Additionally some of the peaks in this data contains dimers and other unidentified ions.
L-Aspartic acid is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly.
L-Aspartic acid is is an amino acid, shown to be a suitable proagent for colon-specific agent deliverly.
Synonyms
96 synonym names
Aspartic Acid, Magnesium (1:1) Salt, Hydrochloride, Trihydrate; Aspartic Acid, Magnesium-Potassium (2:1:2) Salt; Aspartic Acid, Magnesium (2:1) Salt; Hydrochloride, aspartate magnesium; Aspartic Acid, Monopotassium Salt; Aspartate Magnesium Hydrochloride; Aspartic Acid, Dipotassium Salt; Aspartic Acid, Monosodium Salt; 2-Amino-3-methylsuccinic acid; Aspartic Acid, Potassium Salt; Aspartic Acid, Disodium Salt; (2S)-2-aminobutanedioic acid; Aspartic Acid, Hydrochloride; Aspartic Acid, Ammonium Salt; Aspartic Acid, Calcium Salt; Hydrochloride aspartic acid; (S)-2-Aminobutanedioic acid; Aspartic Acid, Hydrobromide; Hydrobromide aspartic acid; (S)-Amino-butanedioic acid; Aspartic Acid, Sodium Salt; 2-Amino-3-methylsuccinate; (S)-Aminobutanedioic acid; (S)-2-Aminosuccinic acid; Aspartate, Monopotassium; alpha-Aminosuccinic acid; (S)-2-Aminobutanedioate; Monopotassium Aspartate; Aspartate, Dipotassium; (S)-Amino-butanedioate; Aspartate, Monosodium; (S)-(+)-Aspartic acid; Dipotassium Aspartate; (S)-Aminobutanedioate; Aspartate, Potassium; (S)-2-Aminosuccinate; (R)-2-Aminosuccinate; 2-Aminosuccinic acid; L-Aminosuccinic acid; Monosodium Aspartate; alpha-Aminosuccinate; Aspartate, Magnesium; Poly-DL-succinimide; L-(+)-Aspartic acid; Potassium Aspartate; Aspartate, Ammonium; Aspartate, Disodium; Magnesium Aspartate; (R,S)-Aspartic Acid; L-Asparaginic acid; (2S)-Aspartic acid; Disodium Aspartate; Ammonium Aspartate; (+-)-Aspartic Acid; Aspartate, Calcium; L-Asparaginsaeure; (L)-Aspartic acid; Calcium aspartate; (S)-Aspartic acid; Aspartate, Sodium; (+)-Aspartic acid; (S)-(+)-Aspartate; Asparaginic acid; Sodium Aspartate; L-Asparagic acid; DL-Aspartic Acid; L-Aminosuccinate; 2-Aminosuccinate; L Aspartic Acid; L-Aspartic Acid; L-(+)-Aspartate; Polysuccinimide; (2S)-Aspartate; L-Asparaginate; Aminosuccinate; Asparagic acid; Aspartic Acid; MG 5 Longoral; Mg-5-Longoral; (+)-Aspartate; (L)-Aspartate; (S)-Aspartate; Asparaginate; L-Asparagate; Magnesiocard; L-Aspartate; MG5Longoral; L Aspartate; Asparatate; Asparagate; Aspartate; H-Asp-OH; L-Asp; Asp; D; Aspartic acid
Cross Reference
57 cross reference id
- ChEBI: CHEBI:17053
- ChEBI: CHEBI:22660
- KEGG: C00049
- KEGGdrug: D70832
- KEGGdrug: D00013
- PubChem: 5960
- PubChem: 424
- HMDB: HMDB0000191
- Metlin: METLIN15
- DrugBank: DB00128
- ChEMBL: CHEMBL274323
- Wikipedia: Aspartic acid
- MeSH: Aspartic Acid
- MetaCyc: L-ASPARTATE
- KNApSAcK: C00001342
- foodb: FDB012567
- chemspider: 5745
- CAS: 56-84-8
- MoNA: KNA00756
- MoNA: PB000455
- MoNA: KO002063
- MoNA: PB000454
- MoNA: RP001602
- MoNA: KNA00757
- MoNA: KNA00381
- MoNA: KNA00380
- MoNA: KNA00489
- MoNA: PB000453
- MoNA: KO002067
- MoNA: KNA00051
- MoNA: RP001601
- MoNA: PB000452
- MoNA: KO000031
- MoNA: KO002064
- MoNA: KO000033
- MoNA: KNA00052
- MoNA: KNA00487
- MoNA: KO002065
- MoNA: KO002066
- MoNA: PS026801
- MoNA: KO000032
- MoNA: KO000030
- MoNA: RP001611
- MoNA: KNA00049
- MoNA: KNA00758
- MoNA: KO000029
- MoNA: KNA00488
- PMhub: MS000000395
- PDB-CCD: ASP
- PDB-CCD: IAS
- 3DMET: B00015
- NIKKAJI: J9.169C
- KEGG: C16433
- NIKKAJI: J44.432D
- medchemexpress: HY-N0666
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-770
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-65
Classification Terms
Related Pathways
Reactome(0)
PlantCyc(0)
Biological Process
25 related biological process reactions.
Reactome(0)
BioCyc(12)
- superpathway of histidine, purine and pyrimidine biosynthesis:
ATP + D-ribose 5-phosphate ⟶ 5-phosphoribosyl 1-pyrophosphate + AMP
- aspartate degradation:
α-ketoglutarate + L-aspartate ⟶ L-glutamate + oxaloacetate
- tRNA charging pathway:
ATP + L-serine ⟶ AMP + pyrophosphate
- homoserine biosynthesis:
ATP + L-aspartate ⟶ ADP + L-aspartyl-4-phosphate
- arginine biosynthesis:
ATP + L-aspartate + citrulline ⟶ AMP + L-arginino-succinate + pyrophosphate
- pyrimidine ribonucleotides de novo biosynthesis:
O2 + dihydroorotate ⟶ H2O2 + orotate
- asparagine degradation:
H2O + L-asparagine ⟶ L-aspartate + ammonia
- asparagine biosynthesis:
ATP + H2O + L-aspartate + L-glutamine ⟶ AMP + L-asparagine + L-glutamate + pyrophosphate
- aspartate biosynthesis:
α-ketoglutarate + L-aspartate ⟶ L-glutamate + oxaloacetate
- glutamine degradation:
L-aspartate ⟶ ammonia + fumarate
- salvage pathways of purine nucleosides:
AMP + pyrophosphate ⟶ 5-phosphoribosyl 1-pyrophosphate + adenine
- purine nucleotides de novo biosynthesis:
ATP + XMP + ammonia ⟶ AMP + GMP + pyrophosphate
WikiPathways(7)
- Cerebral organic acidurias, including diseases:
L-2-Aminoadipic acid ⟶ 2-Oxoadipic acid
- Glycolysis and gluconeogenesis:
Aspartate ⟶ Oxaloacetate
- NAD biosynthesis I from aspartate:
L-Aspartic acid ⟶ Iminoaspartic acid
- Threonine biosynthesis:
L-Aspartate ⟶ L-Aspartyl-4-P
- Metabolism overview:
NH3 ⟶ Glutamic acid
- Metabolic Epileptic Disorders:
P-enolpyruvate ⟶ Pyruvate
- Metabolic reprogramming in pancreatic cancer:
lactate ⟶ pyruvate
Plant Reactome(0)
INOH(5)
- Alanine,Aspartic acid and Asparagine metabolism ( Alanine,Aspartic acid and Asparagine metabolism ):
H2O + N-Acetyl-L-aspartic acid ⟶ Acetic acid + L-Aspartic acid
- Pyrimidine Nucleotides and Nucleosides metabolism ( Pyrimidine Nucleotides and Nucleosides metabolism ):
Deoxy-cytidine + H2O ⟶ Deoxy-uridine + NH3
- 2-Oxo-glutaric acid + L-Aspartic acid = L-Glutamic acid + Oxaloacetic acid ( Alanine,Aspartic acid and Asparagine metabolism ):
L-Glutamic acid + Oxaloacetic acid ⟶ 2-Oxo-glutaric acid + L-Aspartic acid
- Arginine and Proline metabolism ( Arginine and Proline metabolism ):
ATP + Creatine ⟶ ADP + N-Phospho-creatine
- Purine nucleotides and Nucleosides metabolism ( Purine nucleotides and Nucleosides metabolism ):
H2O + XTP ⟶ Pyrophosphate + XMP
PlantCyc(0)
COVID-19 Disease Map(1)
- @COVID-19 Disease
Map["name"]:
Adenosine + Pi ⟶ Adenine + _alpha_-D-Ribose 1-phosphate
PathBank(0)
PharmGKB(0)
7 organism taxonomy source information
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
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Cells.
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2023 Mar; 23(1):150. doi:
10.1186/s12870-023-04158-2
. [PMID: 36941626] - João A Rodrigues, Mónica Silva, Rita Araújo, Leonor Madureira, Amadeu M V M Soares, Rosa Freitas, Ana M Gil. The influence of temperature rise on the metabolic response of Ruditapes philippinarum clams to 17-α-ethinylestradiol.
The Science of the total environment.
2023 Mar; 877(?):162898. doi:
10.1016/j.scitotenv.2023.162898
. [PMID: 36934939] - Leo Bellin, Diana Laura Garza Amaya, Vanessa Scherer, Tobias Pruß, Annalisa John, Andreas Richter, Torsten Möhlmann. Nucleotide Imbalance, Provoked by Downregulation of Aspartate Transcarbamoylase Impairs Cold Acclimation in Arabidopsis.
Molecules (Basel, Switzerland).
2023 Feb; 28(4):. doi:
10.3390/molecules28041585
. [PMID: 36838573] - Simona Todisco, Biagia Musio, Vito Pesce, Maria Maddalena Cavalluzzi, Giuseppe Petrosillo, Gianluigi La Piana, Maria Noemi Sgobba, Nikola Schlosserová, Lucas Cafferati Beltrame, Rosa Di Lorenzo, Vincenzo Tragni, Domenico Marzulli, Lorenzo Guerra, Anna De Grassi, Vito Gallo, Mariateresa Volpicella, Luigi Leonardo Palese, Giovanni Lentini, Ciro Leonardo Pierri. Targeting mitochondrial impairment for the treatment of cardiovascular diseases: From hypertension to ischemia-reperfusion injury, searching for new pharmacological targets.
Biochemical pharmacology.
2023 02; 208(?):115405. doi:
10.1016/j.bcp.2022.115405
. [PMID: 36603686] - Feng Huang, Tong Zhang, Bin Li, Shaosong Wang, Chang Xu, Caihua Huang, Donghai Lin. NMR-based metabolomic analysis for the effects of moxibustion on imiquimod-induced psoriatic mice.
Journal of ethnopharmacology.
2023 Jan; 300(?):115626. doi:
10.1016/j.jep.2022.115626
. [PMID: 36049653] - M S Sadak, B A Bakry, T M Abdel-Razik, R S Hanafy. Amino acids foliar application for maximizing growth, productivity and quality of peanut grown under sandy soil.
Brazilian journal of biology = Revista brasleira de biologia.
2023; 83(?):e256338. doi:
10.1590/1519-6984.256338
. [PMID: 36753149] - Yingjie Ma, Jingyan Song, Xianling Cao, Zhengao Sun. Mechanism of Guilu Erxian ointment based on targeted metabolomics in intervening in vitro fertilization and embryo transfer outcome in older patients with poor ovarian response of kidney-qi deficiency type.
Frontiers in endocrinology.
2023; 14(?):1045384. doi:
10.3389/fendo.2023.1045384
. [PMID: 36742408] - Yi Shi, Qian Wu, Yi Lu, Ling-Peng Meng, Xiao-Ling Xu, Xiao-Juan Wang, Wei Chen. Arginine-Glycine-Aspartic Acid-anchored Curcumin-based Nanotherapeutics Inhibit Pyroptosis-induced Cytokine Release Syndrome for In Vivo and In Vitro Sepsis Applications.
Current pharmaceutical design.
2023; 29(4):283-294. doi:
10.2174/1381612829666230201144029
. [PMID: 36722481] - Si-Yuan Luo, Zhi Huang, Xi Chen, Min-Hua Zong, Wen-Yong Lou. Extraction and characterization of a functional protein from Millettia speciosa Champ. leaf.
Natural product research.
2023 Jan; 37(1):31-38. doi:
10.1080/14786419.2021.1947271
. [PMID: 34212817] - Yunan Hu, Mingxia Li, Yongjun Hu, Defu Han, Jian Wei, Tao Zhang, Jixun Guo, Lianxuan Shi. Wild soybean salt tolerance metabolic model: Assessment of storage protein mobilization in cotyledons and C/N balance in the hypocotyl/root axis.
Physiologia plantarum.
2023 Jan; 175(1):e13863. doi:
10.1111/ppl.13863
. [PMID: 36688582] - Tao Gong, Steve C N Hui, Helge J Zöllner, Mark Britton, Yulu Song, Yufan Chen, Aaron T Gudmundson, Kathleen E Hupfeld, Christopher W Davies-Jenkins, Saipavitra Murali-Manohar, Eric C Porges, Georg Oeltzschner, Weibo Chen, Guangbin Wang, Richard A E Edden. Neurometabolic timecourse of healthy aging.
NeuroImage.
2022 12; 264(?):119740. doi:
10.1016/j.neuroimage.2022.119740
. [PMID: 36356822] - Qing-Qi Chang, Long Chen, Ya-Fang Liao, Chun-Lu Yuan, Dan-Dan Zhang. [Mechanism of timosaponin AⅢ in regulation of metabolism against glioblastoma growth].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Dec; 47(24):6679-6686. doi:
10.19540/j.cnki.cjcmm.20220728.401
. [PMID: 36604918] - Hussain Ahmad, Xinrui Zhao, Nisar Ahmad, Abbas Khan, Yuexin Jin, Jie Du, Xuewei Zheng, Li Zeng, Yanan Ouyang, Pengfei Yang, Meng Chen, Xiaoxue Li, Zhe Yang, Zhongmin Tian. Benincasa hispida extracts positively regulated high salt-induced hypertension in Dahl salt-sensitive rats: Impact on biochemical profile and metabolic patterns.
Journal of food biochemistry.
2022 12; 46(12):e14497. doi:
10.1111/jfbc.14497
. [PMID: 36314446] - Abdur Rouf Samim, Vinay Kumar Singh, Huma Vaseem. Assessment of hazardous impact of nickel oxide nanoparticles on biochemical and histological parameters of gills and liver tissues of Heteropneustes fossilis.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS).
2022 Dec; 74(?):127059. doi:
10.1016/j.jtemb.2022.127059
. [PMID: 35987181] - Zhehua Zhang, Deying Chen, Jiong Yu, Xiaoling Su, Lanjuan Li. Metabolic perturbations in human hepatocytes induced by bis (2-ethylhexyl)-2,3,4,5-tetrabromophthalate exposure: Insights from high-coverage quantitative metabolomics.
Analytical biochemistry.
2022 11; 657(?):114887. doi:
10.1016/j.ab.2022.114887
. [PMID: 36150471] - Hongzhao Yuan, Zhen He, Xiangbi Chen, Tida Ge, Liping Zhang, Jiurong Wang. Rapid, sensitive analysis method for determining the nitrogen stable isotope ratio of total free amino acids in soil.
Rapid communications in mass spectrometry : RCM.
2022 Nov; 36(21):e9390. doi:
10.1002/rcm.9390
. [PMID: 36056455] - Meshal M Almutairi, Hany M Almotairy. Analysis of Heat Shock Proteins Based on Amino Acids for the Tomato Genome.
Genes.
2022 11; 13(11):. doi:
10.3390/genes13112014
. [PMID: 36360251] - Yu Du, Chang Li, Shouchao Xu, Jiehong Yang, Haitong Wan, Yu He. LC-MS/MS combined with blood-brain dual channel microdialysis for simultaneous determination of active components of astragali radix-safflower combination and neurotransmitters in rats with cerebral ischemia reperfusion injury: Application in pharmacokinetic and pharmacodynamic study.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Nov; 106(?):154432. doi:
10.1016/j.phymed.2022.154432
. [PMID: 36113188] - Shangqing Li, Guorong Lyu, Shaohui Li, Hainan Yang, Yiru Yang. Metabolic characterization of amniotic fluid of fetuses with isolated choroid plexus cyst.
Journal of perinatal medicine.
2022 Oct; 50(8):1100-1106. doi:
10.1515/jpm-2022-0028
. [PMID: 35607760] - Hanxia Wang, Qiaoyun Ma, Fuhua Shan, Liping Tian, Jie Gong, Wei Quan, Weibing Yang, Qiling Hou, Fengting Zhang, Shengquan Zhang. Transcriptional regulation mechanism of wheat varieties with different nitrogen use efficiencies in response to nitrogen deficiency stress.
BMC genomics.
2022 Oct; 23(1):727. doi:
10.1186/s12864-022-08948-0
. [PMID: 36289540] - Christian Shema Mugisha, Tung Dinh, Abhishek Kumar, Kasyap Tenneti, Jenna E Eschbach, Keanu Davis, Robert Gifford, Mamuka Kvaratskhelia, Sebla B Kutluay. Emergence of Compensatory Mutations Reveals the Importance of Electrostatic Interactions between HIV-1 Integrase and Genomic RNA.
mBio.
2022 10; 13(5):e0043122. doi:
10.1128/mbio.00431-22
. [PMID: 35975921] - Kouji Uda, Luke A Moe. Distribution and evolution of the serine/aspartate racemase family in invertebrates. II. Frequent and widespread parallel evolution of aspartate racemase.
Journal of biochemistry.
2022 Oct; 172(5):303-311. doi:
10.1093/jb/mvac067
. [PMID: 35997160] - Lillian F Hyde, Yang Kong, Lihong Zhao, Sriganesh Ramachandra Rao, Jieping Wang, Lisa Stone, Andrew Njaa, Gayle B Collin, Mark P Krebs, Bo Chang, Steven J Fliesler, Patsy M Nishina, Jürgen K Naggert. A Dpagt1 Missense Variant Causes Degenerative Retinopathy without Myasthenic Syndrome in Mice.
International journal of molecular sciences.
2022 Oct; 23(19):. doi:
10.3390/ijms231912005
. [PMID: 36233305] - Aradhana Mishra, Arpita Bhattacharya, Priyanka Chauhan, Shipra Pandey, Ashish Dwivedi. Phenotype microarray analysis reveals the biotransformation of Fusarium oxysporum f.sp. lycopersici influenced by Bacillus subtilis PBE-8 metabolites.
FEMS microbiology ecology.
2022 10; 98(10):. doi:
10.1093/femsec/fiac102
. [PMID: 36066920] - Misato Kuroiwa, Syoya Handa, Yutaka Gyoutoku, Miho Moriyama, Yutaro Neriya, Hisashi Nishigawa, Tomohide Natsuaki. Characterization of a ToMV isolate overcoming Tm-22 resistance gene in tomato.
Virus genes.
2022 Oct; 58(5):478-482. doi:
10.1007/s11262-022-01921-9
. [PMID: 35727492] - Yuan Kong, Chenyang Ji, Dong Guo, Rujian He, Meirong Zhao, Jun Fan. Triticonazole enantiomers induced enantioselective metabolic phenotypes in Fusarium graminearum and HepG2 cells.
Environmental science and pollution research international.
2022 Oct; 29(50):75978-75988. doi:
10.1007/s11356-022-21137-6
. [PMID: 35665887] - Ram Prasad Aganja, Chandran Sivasankar, Chamith Hewawaduge, John Hwa Lee. Safety assessment of compliant, highly invasive, lipid A-altered, O-antigen-defected Salmonella strains as prospective vaccine delivery systems.
Veterinary research.
2022 Oct; 53(1):76. doi:
10.1186/s13567-022-01096-z
. [PMID: 36183131] - Zhiyuan Meng, Jiajia Cui, Li Liu, Chunmei Yang, Xin Bao, Jianjun Wang, Xiaojun Chen. Toxicity effects of chlorantraniliprole in zebrafish (Danio rerio) involving in liver function and metabolic phenotype.
Pesticide biochemistry and physiology.
2022 Oct; 187(?):105194. doi:
10.1016/j.pestbp.2022.105194
. [PMID: 36127066] - Ivonne González-Gamboa, Adam A Caparco, Justin M McCaskill, Nicole F Steinmetz. Bioconjugation Strategies for Tobacco Mild Green Mosaic Virus.
Chembiochem : a European journal of chemical biology.
2022 09; 23(18):e202200323. doi:
10.1002/cbic.202200323
. [PMID: 35835718] - Heming Sui, Shiqi Wang, Gang Liu, Fei Meng, Zubing Cao, Yunhai Zhang. Effects of Heat Stress on Motion Characteristics and Metabolomic Profiles of Boar Spermatozoa.
Genes.
2022 09; 13(9):. doi:
10.3390/genes13091647
. [PMID: 36140814] - Che-Wei Lin, Chih-Yun Lee, Sung-Yen Lin, Lin Kang, Yin-Chih Fu, Chung-Hwan Chen, Chih-Kuang Wang. Bone-Targeting Nanoparticles of a Dendritic (Aspartic acid)3-Functionalized PEG-PLGA Biopolymer Encapsulating Simvastatin for the Treatment of Osteoporosis in Rat Models.
International journal of molecular sciences.
2022 Sep; 23(18):. doi:
10.3390/ijms231810530
. [PMID: 36142447] - Venelina Popova, Zhana Petkova, Nadezhda Mazova, Tanya Ivanova, Nadezhda Petkova, Magdalena Stoyanova, Albena Stoyanova, Sezai Ercisli, Zuhal Okcu, Sona Skrovankova, Jiri Mlcek. Chemical Composition Assessment of Structural Parts (Seeds, Peel, Pulp) of Physalis alkekengi L. Fruits.
Molecules (Basel, Switzerland).
2022 Sep; 27(18):. doi:
10.3390/molecules27185787
. [PMID: 36144521] - Ling Gao, Qiang Gu, Hong Wang, Xingkong Ma, Feng Xue, Xing Zhang, Jiachun Ge, Tao Ding, Weijian Shen. [Determination of free amino acids in Eriocheir sinensis by ultra-high performance liquid chromatography-high resolution mass spectrometry].
Se pu = Chinese journal of chromatography.
2022 Sep; 40(9):825-832. doi:
10.3724/sp.j.1123.2022.03027
. [PMID: 36156629] - Pedro García-Caparrós, Lara Vogelsang, Marcus Persicke, Markus Wirtz, Vijay Kumar, Karl-Josef Dietz. Differential sensitivity of metabolic pathways in sugar beet roots to combined salt, heat, and light stress.
Physiologia plantarum.
2022 Sep; 174(5):e13786. doi:
10.1111/ppl.13786
. [PMID: 36169530] - Khaled Mohamed Mohamed Koriem, Marwa A El-Attar. Almond oil restores blood parameters, liver function, blood and liver antioxidants and DNA, and liver histology more efficiently than olive oil in favism.
Journal of complementary & integrative medicine.
2022 Sep; 19(3):599-606. doi:
10.1515/jcim-2022-0086
. [PMID: 35751565] - Takuya Miyakawa, Jian Yang, Masato Kawasaki, Naruhiko Adachi, Ayumu Fujii, Yumiko Miyauchi, Tomonari Muramatsu, Toshio Moriya, Toshiya Senda, Masaru Tanokura. Structural bases for aspartate recognition and polymerization efficiency of cyanobacterial cyanophycin synthetase.
Nature communications.
2022 08; 13(1):5097. doi:
10.1038/s41467-022-32834-8
. [PMID: 36042318] - Lijun Huang, Leiqiang Gong, Xueyan Huo, Lirong Lei, Qi Zhang, Yunjie Hu, Qixuan Kuang, Yu Gui, Yifei Dai, Yucheng Gu, Yun Deng, Dong Wang, Dale Guo. N-acetyldopamine dimer inhibits neuroinflammation through the TLR4/NF-κB and NLRP3/Caspase-1 pathways.
Acta biochimica et biophysica Sinica.
2022 Aug; 55(1):23-33. doi:
10.3724/abbs.2022116
. [PMID: 36017888] - Surabhi Bangarbale, Blythe D Shepard, Shivani Bansal, Meth M Jayatilake, Ryan Kurtz, Moshe Levi, Carolyn M Ecelbarger. Renal Metabolome in Obese Mice Treated with Empagliflozin Suggests a Reduction in Cellular Respiration.
Biomolecules.
2022 08; 12(9):. doi:
10.3390/biom12091176
. [PMID: 36139016] - Michael R MacArthur, Sarah J Mitchell, Katia S Chadaideh, J Humberto Treviño-Villarreal, Jonathan Jung, Krystle C Kalafut, Justin S Reynolds, Charlotte G Mann, Kaspar M Trocha, Ming Tao, Tay-Zar Aye Cho, Anantawat Koontanatechanon, Vladimir Yeliseyev, Lynn Bry, Alban Longchamp, C Keith Ozaki, Caroline A Lewis, Rachel N Carmody, James R Mitchell. Multiomics assessment of dietary protein titration reveals altered hepatic glucose utilization.
Cell reports.
2022 08; 40(7):111187. doi:
10.1016/j.celrep.2022.111187
. [PMID: 35977507] - İbrahim Ethem, Ceyhan Hacıoğlu. Effects of perilipin-5 on lipid metabolism and high-sensitivity cardiac troponin I.
Revista da Associacao Medica Brasileira (1992).
2022 Aug; 68(8):1011-1016. doi:
10.1590/1806-9282.20211377
. [PMID: 36134829] - Qiong Fang, Jing Liu, Lang Chen, Qiaobin Chen, Yan Wang, Zuanfang Li, Wei Fu, Ying Liu. Taurine supplementation improves hippocampal metabolism in immature rats with intrauterine growth restriction (IUGR) through protecting neurons and reducing gliosis.
Metabolic brain disease.
2022 08; 37(6):2077-2088. doi:
10.1007/s11011-021-00896-0
. [PMID: 35048325] - Eleni Rebelos, Giuseppe Daniele, Beatrice Campi, Alessandro Saba, Kalle Koskensalo, Jukka Ihalainen, Ekaterina Saukko, Pirjo Nuutila, Walter H Backes, Jacobus F A Jansen, Pieter C Dagnelie, Sebastian Köhler, Bastiaan E de Galan, Thomas T van Sloten, Coen D A Stehouwer, Ele Ferrannini. Circulating N-Acetylaspartate does not track brain NAA concentrations, cognitive function or features of small vessel disease in humans.
Scientific reports.
2022 Jul; 12(1):11530. doi:
10.1038/s41598-022-15670-0
. [PMID: 35798828] - Teo Atz Dick, Hasan Uludağ. A Polyplex in a Shell: The Effect of Poly(aspartic acid)-Mediated Calcium Carbonate Mineralization on Polyplexes Properties and Transfection Efficiency.
Molecular pharmaceutics.
2022 07; 19(7):2077-2091. doi:
10.1021/acs.molpharmaceut.1c00909
. [PMID: 35649175] - Jiayu Hou, Muhammad Riaz, Lei Yan, Kesong Lu, Cuncang Jiang. Effect of exogenous l-aspartate nano‑calcium on root growth, calcium forms and cell wall metabolism of Brassica napus L.
NanoImpact.
2022 07; 27(?):100415. doi:
10.1016/j.impact.2022.100415
. [PMID: 35981643] - Erica N Grodin, Steven J Nieto, Lindsay R Meredith, Elizabeth Burnette, Joseph O'Neill, Jeffry Alger, Edythe D London, Karen Miotto, Christopher J Evans, Michael R Irwin, Lara A Ray. Effects of ibudilast on central and peripheral markers of inflammation in alcohol use disorder: A randomized clinical trial.
Addiction biology.
2022 07; 27(4):e13182. doi:
10.1111/adb.13182
. [PMID: 35754106] - Jeanne Friedrichs, Rabea Schweiger, Caroline Müller. Unique metabolism of different glucosinolates in larvae and adults of a leaf beetle specialised on Brassicaceae.
Scientific reports.
2022 06; 12(1):10905. doi:
10.1038/s41598-022-14636-6
. [PMID: 35764778] - Mei Han, Xianglei Xu, Xue Li, Mingyue Xu, Mei Hu, Yuan Xiong, Junhu Feng, Hao Wu, Hui Zhu, Tao Su. New Insight into Aspartate Metabolic Pathways in Populus: Linking the Root Responsive Isoenzymes with Amino Acid Biosynthesis during Incompatible Interactions of Fusarium solani.
International journal of molecular sciences.
2022 Jun; 23(12):. doi:
10.3390/ijms23126368
. [PMID: 35742809] - Haoran Zhang, Jiaqiang Huang, Jie Yang, Jingzeng Cai, Qi Liu, Xintong Zhang, Jun Bao, Ziwei Zhang. Cadmium induces apoptosis and autophagy in swine small intestine by downregulating the PI3K/Akt pathway.
Environmental science and pollution research international.
2022 Jun; 29(27):41207-41218. doi:
10.1007/s11356-022-18863-2
. [PMID: 35091949] - Liu Zhen, Zhang Qingyan, Deng Bowen, Sang Feng, Wang Danni, Kang Ning, L I Jie, Zhang Min, Liang Shoupei, Duan Chenchen, Liu Zhibin, X U Qianlei, L I Qiang. Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 expression and its relationship with T cell activation in human immunodeficiency virus/acquired immune deficiency syndrome patients with lung-spleen deficiency syndrome pattern.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2022 06; 42(3):451-457. doi:
10.19852/j.cnki.jtcm.20220408.004
. [PMID: 35610016] - Lucas Rischka, Chrysoula Vraka, Verena Pichler, Sazan Rasul, Lukas Nics, Gregor Gryglewski, Patricia Handschuh, Matej Murgaš, Godber M Godbersen, Leo R Silberbauer, Jakob Unterholzner, Christoph Wotawa, Ahmed Haider, Hazem Ahmed, Roger Schibli, Thomas Mindt, Markus Mitterhauser, Wolfgang Wadsak, Andreas Hahn, Rupert Lanzenberger, Marcus Hacker, Simon M Ametamey. First-in-Humans Brain PET Imaging of the GluN2B-Containing N-methyl-d-aspartate Receptor with (R)-11C-Me-NB1.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2022 06; 63(6):936-941. doi:
10.2967/jnumed.121.262427
. [PMID: 34620732] - Moriaki Saito, Mineko Konishi, Atsuko Miyagi, Yasuhito Sakuraba, Maki Kawai-Yamada, Shuichi Yanagisawa. Arabidopsis nitrate-induced aspartate oxidase gene expression is necessary to maintain metabolic balance under nitrogen nutrient fluctuation.
Communications biology.
2022 05; 5(1):432. doi:
10.1038/s42003-022-03399-5
. [PMID: 35534536] - Pinky Dhatterwal, Sandhya Mehrotra, Anthony J Miller, Raviprasad Aduri, Rajesh Mehrotra. Effect of ACGT motif in spatiotemporal regulation of AtAVT6D, which improves tolerance to osmotic stress and nitrogen-starvation.
Plant molecular biology.
2022 May; 109(1-2):67-82. doi:
10.1007/s11103-022-01256-x
. [PMID: 35377091] - Ali Madian, Ahmed Eliwa, Hytham Abdalla, Haitham A Azeem Aly. Aspartate transferase-to-platelet ratio index-plus: A new simplified model for predicting the risk of mortality among patients with COVID-19.
World journal of gastroenterology.
2022 Apr; 28(16):1671-1680. doi:
10.3748/wjg.v28.i16.1671
. [PMID: 35581967] - Huanchen Wang, Lalith Perera, Nikolaus Jork, Guangning Zong, Andrew M Riley, Barry V L Potter, Henning J Jessen, Stephen B Shears. A structural exposé of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop.
Nature communications.
2022 04; 13(1):2231. doi:
10.1038/s41467-022-29673-y
. [PMID: 35468885] - Ernst R Werner, Monica L Fernández-Quintero, Nicolas Hulo, Georg Golderer, Sabrina Sailer, Katharina Lackner, Gabriele Werner-Felmayer, Klaus R Liedl, Katrin Watschinger. Essential role of a conserved aspartate for the enzymatic activity of plasmanylethanolamine desaturase.
Cellular and molecular life sciences : CMLS.
2022 Mar; 79(4):214. doi:
10.1007/s00018-022-04238-w
. [PMID: 35347434] - Yindan Lin, Ze Yang, Jingjia Li, Yandi Sun, Xueyun Zhang, Zihao Qu, Yan Luo, Lihong Zhang. Effects of glutamate and aspartate on prostate cancer and breast cancer: a Mendelian randomization study.
BMC genomics.
2022 Mar; 23(1):213. doi:
10.1186/s12864-022-08442-7
. [PMID: 35296245] - Thaysa Mara Gazzotto Neves, Estefania Simoes, Maria Concepcíon García Otaduy, Elie Leal de Barros Calfat, Pâmela Bertolazzi, Naomi Antunes da Costa, Fábio Luís de Souza Duran, Joanna Correia-Lima, Maria da Graça Morais Martin, Marília Cerqueira Leite Seelander, Victor Henrique Oyamada Otani, Thais Zélia Dos Santos Otani, Daniel Augusto Corrêa Vasques, Geraldo Busatto Filho, Cristiane Kochi, Ricardo Riyoiti Uchida. Inverse Association Between Hypothalamic N-Acetyl Aspartate/Creatine Ratio and Indices of Body Mass in Adolescents with Obesity.
The Journal of nutrition.
2022 03; 152(3):663-670. doi:
10.1093/jn/nxab415
. [PMID: 34888674] - Xinying Gao, Haixu Liu, Han Yu, Zhuoqun Zhang, Xiangqi Bi, Yifan Zhao, Tai An, Jingzhi Wen. Combination of Developmental Behaviors and Transcriptome Reveals Differential Response Mechanisms of Phytophthora sojae to Aspartic Acid and Glucose in Seed Exudates.
Phytopathology.
2022 Mar; 112(3):620-629. doi:
10.1094/phyto-08-21-0332-r
. [PMID: 34445895] - Nathaniel Yakobov, Nassira Mahmoudi, Guillaume Grob, Daisuke Yokokawa, Yusuke Saga, Tetsuo Kushiro, Danielle Worrell, Hervé Roy, Hubert Schaller, Bruno Senger, Laurence Huck, Gisela Riera Gascon, Hubert D Becker, Frédéric Fischer. RNA-dependent synthesis of ergosteryl-3β-O-glycine in Ascomycota expands the diversity of steryl-amino acids.
The Journal of biological chemistry.
2022 03; 298(3):101657. doi:
10.1016/j.jbc.2022.101657
. [PMID: 35131263] - Kimberly A Lewis, Nico Osier, Ruy Carrasco, Jennifer Chiou, Patricia Carter, Alexandra Garcia, Elena Flowers, Efstathios D Gennatas, Christina Nguyen, Ambreen Rana, Sharon A Brown, Stefano Tiziani. Serine, N-acetylaspartate differentiate adolescents with juvenile idiopathic arthritis compared with healthy controls: a metabolomics cross-sectional study.
Pediatric rheumatology online journal.
2022 Feb; 20(1):12. doi:
10.1186/s12969-022-00672-z
. [PMID: 35144633] - Oleg Ya Shatursky, Alexander P Demchenko, Ihor Panas, Natalia Krisanova, Natalia Pozdnyakova, Tatiana Borisova. The ability of carbon nanoparticles to increase transmembrane current of cations coincides with impaired synaptic neurotransmission.
Biochimica et biophysica acta. Biomembranes.
2022 02; 1864(1):183817. doi:
10.1016/j.bbamem.2021.183817
. [PMID: 34767780] - Susan Morgello, Korhan Buyukturkoglu, Jacinta Murray, Mike Veenstra, Joan W Berman, Desiree Byrd, Matilde Inglese. MR spectroscopy and diffusion imaging in people with human immunodeficiency virus: Relationships to clinical and immunologic findings.
Journal of neuroimaging : official journal of the American Society of Neuroimaging.
2022 01; 32(1):158-170. doi:
10.1111/jon.12931
. [PMID: 34520593] - Muqing Zhang, Jian Chen, Yanwei Wang, Guobin Kang, Yixin Zhang, Xue Han. Network Pharmacology-Based Combined with Experimental Validation Study to Explore the Underlying Mechanism of Agrimonia pilosa Ledeb. Extract in Treating Acute Myocardial Infarction.
Drug design, development and therapy.
2022; 16(?):3117-3132. doi:
10.2147/dddt.s370473
. [PMID: 36132334] - Chenxi Wang, You Zheng, Zubiao Niu, Xiaoyi Jiang, Qiang Sun. The virological impacts of SARS-CoV-2 D614G mutation.
Journal of molecular cell biology.
2021 12; 13(10):712-720. doi:
10.1093/jmcb/mjab045
. [PMID: 34289053] - Anna Scortica, Matteo Capone, Daniele Narzi, Mario Frezzini, Valentina Scafati, Moira Giovannoni, Francesco Angelucci, Leonardo Guidoni, Benedetta Mattei, Manuel Benedetti. A molecular dynamics-guided mutagenesis identifies two aspartic acid residues involved in the pH-dependent activity of OG-OXIDASE 1.
Plant physiology and biochemistry : PPB.
2021 Dec; 169(?):171-182. doi:
10.1016/j.plaphy.2021.11.011
. [PMID: 34800821]