Dethiobiotin (BioDeep_00000001323)
Main id: BioDeep_00000400006
Secondary id: BioDeep_00001868851
human metabolite PANOMIX_OTCML-2023 Endogenous BioNovoGene_Lab2019
代谢物信息卡片
6-[(4R,5S)-5-methyl-2-oxoimidazolidin-4-yl]hexanoic acid
化学式: C10H18N2O3 (214.1317358)
中文名称: 5-甲基-2-氧-4-咪唑啉己酸, D-脱硫生物素, d-Desthiobiotin
谱图信息:
最多检出来源 Viridiplantae(plant) 4.22%
分子结构信息
SMILES: CC1C(NC(=O)N1)CCCCCC(=O)O
InChI: InChI=1S/C10H18N2O3/c1-7-8(12-10(15)11-7)5-3-2-4-6-9(13)14/h7-8H,2-6H2,1H3,(H,13,14)(H2,11,12,15)
描述信息
Dethiobiotin is a synthetic metabolite that mimic the effects of biotin on gene expression and thus have biotin-like activities. In mammals, biotin serves as a coenzyme for carboxylases such as propionyl-CoA carboxylase. (PMID 12730407) [HMDB]. Dethiobiotin is found in many foods, some of which are agave, garden onion, lime, and black mulberry.
Dethiobiotin is a synthetic metabolite that mimic the effects of biotin on gene expression and thus have biotin-like activities. In mammals, biotin serves as a coenzyme for carboxylases such as propionyl-CoA carboxylase. (PMID 12730407).
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D050258 - Mitosis Modulators > D008934 - Mitogens
KEIO_ID D075; [MS3] KO009104
KEIO_ID D075; [MS2] KO009103
KEIO_ID D075
D-Desthiobiotin is a biotin derivative used in affinity chromatography and protein chromatography. D-Desthiobiotin also can be used for protein and cell labeling, detection and isolation[1].
同义名列表
21 个代谢物同义名
6-[(4R,5S)-5-methyl-2-oxoimidazolidin-4-yl]hexanoic acid; (4R-cis)-5-Methyl-2-oxo-4-imidazolidinehexanoic acid; (4R,5S)-5-Methyl-2-oxo-4-imidazolidinehexanoic acid; (4R-cis)-5-Methyl-2-oxo-4-imidazolidinehexanoate; epsilon-(4-Methyl-5-imidazolidone-2)caproic acid; (4R,5S)-5-Methyl-2-oxo-4-imidazolidinehexanoate; 4-Methyl-5-(omega-carboxyamyl)imidazolidone-2; 5-Methyl-2-oxo-4-imidazolidinehexanoic acid; ε-(4-Methyl-5-imidazolidone-2)caproic acid; 5-Methyl-2-oxo-4-imidazolidinecaproic acid; 4-Methyl-5-(ω-carboxyamyl)imidazolidone-2; Desthiobiotin, (cis)-(+-)-isomer; Desthiobiotin, (4R-cis)-isomer; (4R,5S)-dethiobiotin; (+)-Dethiobiotin; dl-Dithiobiotin; D-Dethiobiotin; Desthiobiotin; dethiobiotin; Dethiobiotin; D-Desthiobiotin
数据库引用编号
34 个数据库交叉引用编号
- ChEBI: CHEBI:16691
- ChEBI: CHEBI:42280
- KEGG: C01909
- PubChem: 445027
- PubChem: 643
- HMDB: HMDB0003581
- Metlin: METLIN3351
- DrugBank: DB03775
- ChEMBL: CHEMBL1232381
- ChEMBL: CHEMBL4585840
- MetaCyc: DETHIOBIOTIN
- KNApSAcK: C00000757
- foodb: FDB023201
- chemspider: 392787
- CAS: 15720-25-9
- CAS: 12022-42-3
- CAS: 636-20-4
- CAS: 533-48-2
- MoNA: KO002732
- MoNA: KO009106
- MoNA: KO002733
- MoNA: KO009105
- MoNA: KO002734
- MoNA: KO009104
- MoNA: KO009103
- MoNA: KO002735
- MoNA: KO002731
- PMhub: MS000000332
- PubChem: 5017
- 3DMET: B04822
- NIKKAJI: J9.406D
- RefMet: Dethiobiotin
- medchemexpress: HY-128699
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-475
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
242 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(240)
- Metabolism and regulation:
ATP + CoA + propionate ⟶ AMP + PPi + PROP-CoA - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Cofactor biosyntheses:
9-mercaptodethiobiotin ⟶ Btn - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Cofactor biosyntheses:
5,10-methylene-THF + H2O + KIV ⟶ 2-dehydropantoate + THF - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Cofactor biosyntheses:
5,10-methylene-THF + H2O + KIV ⟶ 2-dehydropantoate + THF - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Cofactor biosyntheses:
5,10-methylene-THF + H2O + KIV ⟶ 2-dehydropantoate + THF - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Cofactor biosyntheses:
5,10-methylene-THF + H2O + KIV ⟶ 2-dehydropantoate + THF - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Cofactor biosyntheses:
5,10-methylene-THF + H2O + KIV ⟶ 2-dehydropantoate + THF - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Cofactor biosyntheses:
5,10-methylene-THF + H2O + KIV ⟶ 2-dehydropantoate + THF - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Cofactor biosyntheses:
5,10-methylene-THF + H2O + KIV ⟶ 2-dehydropantoate + THF - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Cofactor biosyntheses:
5,10-methylene-THF + H2O + KIV ⟶ 2-dehydropantoate + THF - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Cofactor biosyntheses:
5,10-methylene-THF + H2O + KIV ⟶ 2-dehydropantoate + THF - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
5,10-methylene-THF + H2O + KIV ⟶ 2-dehydropantoate + THF - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Cofactor biosyntheses:
5,10-methylene-THF + H2O + KIV ⟶ 2-dehydropantoate + THF - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Cofactor biosyntheses:
2OG + L-Val ⟶ KIV + L-Glu - Biotin biosynthesis II:
9-mercaptodethiobiotin ⟶ Btn
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(2)
- Biotin Metabolism:
Dethiobiotin + Hydrogen Ion + S-Adenosylmethionine + a sulfurated [sulfur carrier] ⟶ 5'-Deoxyadenosine + Biotin + L-Methionine - Biotin Metabolism:
Adenosine triphosphate + Biotin ⟶ Biotinyl-5'-AMP + diphosphate
PharmGKB(0)
5 个相关的物种来源信息
- 7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
- 3039 - Euglena gracilis: 10.3389/FBIOE.2021.662655
- 9606 - Homo sapiens: -
- 217554 - Scaphyglottis livida: 10.1016/J.JEP.2007.07.021
- 32046 - Synechococcus elongatus: 10.1111/1462-2920.12899
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Di Qu, Peng Ge, Laure Botella, Sae Woong Park, Ha-Na Lee, Natalie Thornton, James M Bean, Inna V Krieger, James C Sacchettini, Sabine Ehrt, Courtney C Aldrich, Dirk Schnappinger. Mycobacterial biotin synthases require an auxiliary protein to convert dethiobiotin into biotin.
Nature communications.
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The EMBO journal.
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Fungal genetics and biology : FG & B.
2011 Feb; 48(2):208-15. doi:
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PloS one.
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PloS one.
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BMC microbiology.
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American journal of physiology. Renal physiology.
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The Journal of investigative dermatology.
2003 Mar; 120(3):428-33. doi:
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Yeast (Chichester, England).
2003 Feb; 20(3):221-31. doi:
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