Adenosine diphosphate (BioDeep_00000001284)

 

Secondary id: BioDeep_00000400395, BioDeep_00001890787

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019 Volatile Flavor Compounds


代谢物信息卡片


[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid

化学式: C10H15N5O10P2 (427.029415)
中文名称: 二磷酸腺苷, 腺苷-5'-二磷酸 钠盐, 腺苷二磷酸, 腺苷-5'-二磷酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.16%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

Adenosine diphosphate. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/adenosine_diphosphate (retrieved 2024-11-22) (BioDeep RN: BioDeep_00000001284). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C([C@@H]1[C@H]([C@H]([C@H](n2cnc3c(N)ncnc23)O1)O)O)OP(=O)(O)OP(=O)(O)O
InChI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

描述信息

Adenosine diphosphate (ADP), also known as adenosine pyrophosphate (APP), is an important organic compound in metabolism and is essential to the flow of energy in living cells. ADP consists of three important structural components: a sugar backbone attached to adenine and two phosphate groups bonded to the 5 carbon atom of ribose. The diphosphate group of ADP is attached to the 5’ carbon of the sugar backbone, while the adenine attaches to the 1’ carbon. ADP belongs to the class of organic compounds known as purine ribonucleoside diphosphates. These are purine ribobucleotides with diphosphate group linked to the ribose moiety. It is an ester of pyrophosphoric acid with the nucleotide adenine. Adenosine diphosphate is a nucleotide. ADP exists in all living species, ranging from bacteria to humans. In humans, ADP is involved in d4-gdi signaling pathway. ADP is the product of ATP dephosphorylation by ATPases. ADP is converted back to ATP by ATP synthases. ADP consists of the pyrophosphate group, the pentose sugar ribose, and the nucleobase adenine.
Adenosine diphosphate, abbreviated ADP, is a nucleotide. It is an ester of pyrophosphoric acid with the nucleotide adenine. ADP consists of the pyrophosphate group, the pentose sugar ribose, and the nucleobase adenine.

5′-ADP. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=58-64-0 (retrieved 2024-07-01) (CAS RN: 58-64-0). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P2T-purinoceptors.
Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P2T-purinoceptors.

同义名列表

28 个代谢物同义名

[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphonic acid; Adenosine-5-diphosphate Di(monocyclohexylammonium)salt; Adenosine 5-diphosphoric acid; ADENOSINE-5-diphosphoric acid; Adenosine diphosphoric acid; 5-Pyrophosphate, adenosine; Adenosine 5-pyrophosphate; Adenosine diphosphate;ADP; Adenosine 5 pyrophosphate; Adenosindiphosphorsaeure; Pyrophosphate, adenosine; Adenosine pyrophosphate; 5-Adenylphosphoric acid; ADENOSINE-5-diphosphATE; Adenosine-5-diphosphate; Adenosine 5-diphosphate; Diphosphate, adenosine; Adenosine diphosphate; Adenosine-diphosphate; 5-Adenylphosphate; ADP, Magnesium; Magnesium ADP; MgADP; H3ADP; ADP; Adenosine-5'-diphosphate(ADP); Adenosine 5'-diphosphate; ADP



数据库引用编号

37 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(7)

BioCyc(83)

PlantCyc(0)

代谢反应

14593 个相关的代谢反应过程信息。

Reactome(1363)

BioCyc(655)

WikiPathways(4)

Plant Reactome(4764)

INOH(46)

PlantCyc(6)

COVID-19 Disease Map(3)

PathBank(7752)

PharmGKB(0)

59 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • David Calderón Guzmán, Norma Osnaya Brizuela, Maribel Ortíz Herrera, Hugo Juárez Olguín, Armando Valenzuela Peraza, Norma Labra Ruíz, Gerardo Barragán Mejía. Intake of oligoelements with cytarabine or etoposide alters dopamine levels and oxidative damage in rat brain. Scientific reports. 2024 05; 14(1):10835. doi: 10.1038/s41598-024-61766-0. [PMID: 38736022]
  • Jin Huang, Xuewen Liang, Minrui Zhao, Yue Zhang, Ziyang Chen. Metabolomics and network pharmacology reveal the mechanism of antithrombotic effect of Asperosaponin VI. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Apr; 173(?):116355. doi: 10.1016/j.biopha.2024.116355. [PMID: 38493592]
  • Artūras Polita, Rokas Žvirblis, Jelena Dodonova-Vaitkūnienė, Arun Prabha Shivabalan, Karolina Maleckaitė, Gintaras Valinčius. Bimodal effects on lipid droplets induced in cancer and non-cancer cells by chemotherapy drugs as revealed with a green-emitting BODIPY fluorescent probe. Journal of materials chemistry. B. 2024 Mar; 12(12):3022-3030. doi: 10.1039/d3tb02979d. [PMID: 38426244]
  • Yue Wang, Ping Wang, Haiyan Li, Xiaoran Han, Haibin Zhu, Xiangqun Jin. Nanocrystal-Loaded Lipid Carriers for Improved Oral Absorption and Anticancer Efficacy of Etoposide: Formulation Development, Transport Mechanism, In Vitro and In Vivo Evaluation. Molecular pharmaceutics. 2024 Mar; 21(3):1170-1181. doi: 10.1021/acs.molpharmaceut.3c00785. [PMID: 38329909]
  • Mohammed M Jalal, Claire S Whyte, Fraser P Coxon, Nicola J Mutch. Atorvastatin-mediated inhibition of prenylation of Rab27b and Rap1a in platelets attenuates their prothrombotic capacity and modulates clot structure. Platelets. 2023 Dec; 34(1):2206921. doi: 10.1080/09537104.2023.2206921. [PMID: 37139869]
  • Andrzej M Woyda-Ploszczyca. Direct and indirect targets of carboxyatractyloside, including overlooked toxicity toward nucleoside diphosphate kinase (NDPK) and mitochondrial H+ leak. Pharmaceutical biology. 2023 Dec; 61(1):372-390. doi: 10.1080/13880209.2023.2168704. [PMID: 36799406]
  • Alma Sarahi Cuellar González, Marisol Galván Valencia, Rodolfo Daniel Cervantes-Villagrana, Alondra Bocanegra Zapata, Alberto Rafael Cervantes-Villagrana. Cytotoxic and Antitumor Effects of the Hydroalcoholic Extract of Tagetes erecta in Lung Cancer Cells. Molecules (Basel, Switzerland). 2023 Oct; 28(20):. doi: 10.3390/molecules28207055. [PMID: 37894532]
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  • Tomasz Tuzimski, Anna Petruczynik, Tomasz Plech, Barbara Kaproń, Anna Makuch-Kocka, Małgorzata Szultka-Młyńska, Justyna Misiurek, Bogusław Buszewski, Monika Waksmundzka-Hajnos. Determination of Selected Isoquinoline Alkaloids from Chelidonium majus, Mahonia aquifolium and Sanguinaria canadensis Extracts by Liquid Chromatography and Their In Vitro and In Vivo Cytotoxic Activity against Human Cancer Cells. International journal of molecular sciences. 2023 Mar; 24(7):. doi: 10.3390/ijms24076360. [PMID: 37047332]
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  • Ting Li, Jiesen Yu, Mengyuan Hou, Sijie Zha, Qingqing Cheng, Qingshan Zheng, Lujin Li. Quantitative evaluation of therapy options for relapsed/refractory diffuse large B-cell lymphoma: A model-based meta-analysis. Pharmacological research. 2023 01; 187(?):106592. doi: 10.1016/j.phrs.2022.106592. [PMID: 36470547]
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  • Dongsheng Yao, Heba Ahmed, Junqi Song. A Clickable NAD+ Analog-Based Assay of Poly(ADP-Ribosyl)ated Proteins. Methods in molecular biology (Clifton, N.J.). 2023; 2609(?):147-155. doi: 10.1007/978-1-0716-2891-1_10. [PMID: 36515835]
  • Pengfei Hu, Jinchi Ying, Yusu Wang, Tiantian Jiang, Zheng Pan, Chen Zhao, Jiping Li, Chunyi Li. Extracellular Vesicles Derived From 3D Cultured Antler Stem Cells Serve as a New Drug Vehicle in Osteosarcoma Treatment. Cell transplantation. 2023 Jan; 32(?):9636897231219830. doi: 10.1177/09636897231219830. [PMID: 38102784]
  • Leszek A Kleczkowski, Abir U Igamberdiev. Magnesium and cell energetics: At the junction of metabolism of adenylate and non-adenylate nucleotides. Journal of plant physiology. 2023 Jan; 280(?):153901. doi: 10.1016/j.jplph.2022.153901. [PMID: 36549033]
  • Zahra Amri, Ikram Ben Amor, Amira Zarrouk, Raja Chaaba, Jalel Gargouri, Mohamed Hammami, Sonia Hammami. Anti-glycation, antiplatelet and antioxidant effects of different pomegranate parts. BMC complementary medicine and therapies. 2022 Dec; 22(1):339. doi: 10.1186/s12906-022-03824-6. [PMID: 36575459]
  • G M Li, Y B Jin, Y Z Gan, C Chen, Y Jia, C Li. [Ruxolitinib as an effective treatment for panniculitis associated hemophagocytic syndrome: A report of 2 cases and literature review]. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences. 2022 Dec; 54(6):1208-1213. doi: . [PMID: 36533357]
  • Viacheslav V Dolgikh, Igor V Senderskiy, Sergej A Timofeev, Vladimir S Zhuravlyov, Alexandra V Dolgikh, Elena V Seliverstova, Diloram A Ismatullaeva, Bakhtiyar A Mirzakhodjaev. Construction of scFv Antibodies against the Outer Loops of the Microsporidium Nosema bombycis ATP/ADP-Transporters and Selection of the Fragment Efficiently Inhibiting Parasite Growth. International journal of molecular sciences. 2022 Dec; 23(23):. doi: 10.3390/ijms232315307. [PMID: 36499634]
  • Zhang Tao, Xingwang Kuai, Guangwei Wang, Sanfeng Liu, Kai Liu, Heng Zhang, Shujing Xia, Hua Zhu. Combination of chemotherapy and immune checkpoint therapy by the immunoconjugates-based nanocomplexes synergistically improves therapeutic efficacy in SCLC. Drug delivery. 2022 Dec; 29(1):1571-1581. doi: 10.1080/10717544.2022.2039803. [PMID: 35612299]
  • Jixing Lyu, Chang Liu, Tianqi Zhang, Samantha Schrecke, Nicklaus P Elam, Charles Packianathan, Georg K A Hochberg, David Russell, Minglei Zhao, Arthur Laganowsky. Structural basis for lipid and copper regulation of the ABC transporter MsbA. Nature communications. 2022 11; 13(1):7291. doi: 10.1038/s41467-022-34905-2. [PMID: 36435815]
  • Zhang Yong, Wang Ruiqi, Yang Yanan, Ma Ning, Zhou Zhi, Tan Yinfeng, Dong Lin, Li Yiying, Lu Weiying, Wu Chongming, Zhang Xiaopo. Laurolitsine ameliorates type 2 diabetes by regulating the hepatic LKB1-AMPK pathway and gut microbiota. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Nov; 106(?):154423. doi: 10.1016/j.phymed.2022.154423. [PMID: 36075181]
  • Pan Wang, Xingrong Peng, Tao Hou, Fangfang Xu, Han Zhou, Yancheng Yu, Minghua Qiu, Yanfang Liu, Yaopeng Zhao, Zhimou Guo, Jixia Wang, Xinmiao Liang. Discovery and characterization of novel ATP citrate lyase inhibitors from natural products by a luminescence-based assay. Chemico-biological interactions. 2022 Nov; 367(?):110199. doi: 10.1016/j.cbi.2022.110199. [PMID: 36174740]
  • Aveek Samanta, Saptadipa Banerjee, Tilak Raj Maity, Jangala Jahnavi, Siraj Datta. Towards establishment of a plant-based model to assess the novel anti-cancerous lead molecule(s): An in silico, in vivo and in vitro assessment of some potential anti-cancerous drugs on Lathyrus sativus L. Protoplasma. 2022 Nov; 259(6):1455-1466. doi: 10.1007/s00709-022-01745-2. [PMID: 35195768]
  • James A Whitlock, Jemily Malvar, Luciano Dalla-Pozza, John M Goldberg, Lewis B Silverman, David S Ziegler, Andishe Attarbaschi, Patrick A Brown, Rebecca A Gardner, Paul S Gaynon, Raymond Hutchinson, Van T Huynh, Sima Jeha, Leigh Marcus, Yoav Messinger, Kirk R Schultz, Jeannette Cassar, Franco Locatelli, C Michel Zwaan, Brent L Wood, Richard Sposto, Lia Gore. Nelarabine, etoposide, and cyclophosphamide in relapsed pediatric T-acute lymphoblastic leukemia and T-lymphoblastic lymphoma (study T2008-002 NECTAR). Pediatric blood & cancer. 2022 Nov; 69(11):e29901. doi: 10.1002/pbc.29901. [PMID: 35989458]
  • Stacie S Kim, Diego L Wengier, Carin J Ragland, Elizabeth S Sattely. Transcriptional Reactivation of Lignin Biosynthesis for the Heterologous Production of Etoposide Aglycone in Nicotiana benthamiana. ACS synthetic biology. 2022 10; 11(10):3379-3387. doi: 10.1021/acssynbio.2c00289. [PMID: 36122905]
  • Ping-An Yao, Ke-Zhao Wei, Jia-Hua Feng, Xiao-Ning Liu, Xu Xu, Hong-Yan Cui, Xiao-Chen Zhang, Jian-Ping Gao. Sodium houttuyfonate protects against cardiac injury by regulating cardiac energy metabolism in diabetic rats. European journal of pharmacology. 2022 Oct; 932(?):175236. doi: 10.1016/j.ejphar.2022.175236. [PMID: 36044971]
  • Daniel Mouzo, Raquel Rodríguez-Vázquez, Carlos Barrio, Lucio García, Carlos Zapata. Comparative Proteomics of Potato Cultivars with a Variable Dormancy Period. Molecules (Basel, Switzerland). 2022 Oct; 27(19):. doi: 10.3390/molecules27196621. [PMID: 36235158]
  • Jun Gyou Park, Songwon Kim, Eunhong Jang, Seung Hun Choi, Hyunsu Han, Seulgi Ju, Ji Won Kim, Da Sol Min, Mi Sun Jin. The lysosomal transporter TAPL has a dual role as peptide translocator and phosphatidylserine floppase. Nature communications. 2022 10; 13(1):5851. doi: 10.1038/s41467-022-33593-2. [PMID: 36195619]
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  • Xiao Chang, Yanhong He, Ling Wang, Chuanjin Luo, Yuntao Liu, Rong Li. Puerarin Alleviates LPS-Induced H9C2 Cell Injury by Inducing Mitochondrial Autophagy. Journal of cardiovascular pharmacology. 2022 10; 80(4):600-608. doi: 10.1097/fjc.0000000000001315. [PMID: 35881898]
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  • Maryna Stasevych, Viktor Zvarych, Olena Yaremkevych, Mykhaylo Vovk, Alla Vaskevych, Tetiana Halenova, Olexii Savchuk. N-(9,10-Dioxo-9,10-dihydroanthracen-1(2)-yl)-2-(R-thio) Acetamides: Synthesis, Antioxidant and Antiplatelet Activity. Acta chimica Slovenica. 2022 Sep; 69(3):584-595. doi: 10.17344/acsi.2022.7463. [PMID: 36196813]
  • Hai Shang, Yue Hu, Jingrong Li, Lingyu Li, Yu Tian, Xiaoxue Li, Qi Wu, Zhongmei Zou. The Synthesis and Biological Evaluation of Aloe-Emodin-Coumarin Hybrids as Potential Antitumor Agents. Molecules (Basel, Switzerland). 2022 Sep; 27(19):. doi: 10.3390/molecules27196153. [PMID: 36234685]
  • Lyanne Rodríguez, Andrés Trostchansky, Hermine Vogel, Irene Wood, Iván Palomo, Sergio Wehinger, Eduardo Fuentes. A Comprehensive Literature Review on Cardioprotective Effects of Bioactive Compounds Present in Fruits of Aristotelia chilensis Stuntz (Maqui). Molecules (Basel, Switzerland). 2022 Sep; 27(19):. doi: 10.3390/molecules27196147. [PMID: 36234679]
  • Nikolaos Fragakis, Antonios P Antoniadis, Melani Sotiriadou, Christina Virgiliou, Iris Ballauri, Helen G Gika, Dimitrios Bougiouklis, Spyros Gerou, Charalampos Lazaridis, Stavros Vergopoulos, Constantinos Bakogiannis, Georgios Giannopoulos, Georgios A Theodoridis, Christodoulos E Papadopoulos, Theodoros D Karamitsos, Vassilios Vassilikos. Syncope without prodromes is associated with excessive plasma release of adenosine at the time of syncope during head-up tilt table test. International journal of cardiology. 2022 Sep; 363(?):43-48. doi: 10.1016/j.ijcard.2022.06.045. [PMID: 35716941]
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  • Zalina I Iskhakova, Darya E Zhuravleva, Christopher Heim, Marcus D Hartmann, Aleksandr V Laykov, Karl Forchhammer, Airat R Kayumov. PotN represents a novel energy-state sensing PII subfamily, occurring in firmicutes. The FEBS journal. 2022 09; 289(17):5305-5321. doi: 10.1111/febs.16431. [PMID: 35285159]
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