Gastrodin (BioDeep_00000000124)

   

natural product PANOMIX_OTCML-2023


代谢物信息卡片


(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-(hydroxymethyl)phenoxy)-tetrahydro-2H-pyran-3,4,5-triol

化学式: C13H18O7 (286.10524780000003)
中文名称: 天麻素, 天麻素
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 2.56%

分子结构信息

SMILES: C1=CC(=CC=C1CO)OC2C(C(C(C(O2)CO)O)O)O
InChI: InChI=1S/C13H18O7/c14-5-7-1-3-8(4-2-7)19-13-12(18)11(17)10(16)9(6-15)20-13/h1-4,9-18H,5-6H2

描述信息

Gastrodin is a glycoside.
Gastrodin is a natural product found in Cyrtosia septentrionalis, Dactylorhiza hatagirea, and other organisms with data available.
See also: Gastrodia elata tuber (part of).
Gastrodin, a main constituent of a Chinese herbal medicine Tianma, has been known to display anti-inflammatory effects. Gastrodin, has long been used for treating dizziness, epilepsy, stroke and dementia.
Gastrodin, a main constituent of a Chinese herbal medicine Tianma, has been known to display anti-inflammatory effects. Gastrodin, has long been used for treating dizziness, epilepsy, stroke and dementia.

同义名列表

43 个代谢物同义名

(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-(hydroxymethyl)phenoxy)-tetrahydro-2H-pyran-3,4,5-triol; (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-(hydroxymethyl)phenoxy)tetrahydro-2H-pyran-3,4,5-triol; (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[4-(hydroxymethyl)phenoxy]oxane-3,4,5-triol; 4-HYDROXYBENZYL ALCOHOL 4-O-.BETA.-D-GLUCOPYRANOSIDE; .BETA.-D-GLUCOPYRANOSIDE, 4-(HYDROXYMETHYL)PHENYL-; 4-HYDROXYBENZYL ALCOHOL 4-O-beta-D-GLUCOPYRANOSIDE; .BETA.-D-GLUCOPYRANOSIDE, 4-(HYDROXYMETHYL)PHENYL; beta-D-GLUCOPYRANOSIDE, 4-(HYDROXYMETHYL)PHENYL-; beta-D-Glucopyranoside, 4-(hydroxymethyl)phenyl; 4-(Hydroxymethyl)phenyl-beta-D-glucopyranoside; 4-(Hydroxymethyl)phenyl beta-D-Glucopyranoside; 4-(Hydroxymethyl)phenylbeta-D-Glucopyranoside; 4-(.BETA.-D-GLUCOPYRANOSYLOXY)BENZYL ALCOHOL; b-D-Glucopyranoside, 4-(hydroxymethyl)phenyl; 4-[beta-d-glucopyranosyloxy] benzyl alcohol; 4-(beta-D-glucopyranosyloxy)benzyl alcohol; 4-(.BETA.-D-GLUCOPYRANOSYL)-BENZYLALCOHOL; Gastrodin, from Gastrodia alata, >=98\\%; 4-(beta-D-GLUCOPYRANOSYL)-BENZYLALCOHOL; 4-|A-D-Glucopyranosyloxybenzyl alcohol; (4-(hydroxymethyl)phenoxy)tetrahydro-; (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-; Gastrodin, >=98\\% (HPLC); Gastrodin (Gastrodine); Gastrodin Hemihydrate; 2H-pyran-3,4,5-triol; GASTRODIN [WHO-DD]; GASTRODIN [INCI]; UNII-5YS9U2W3RQ; GASTRODIN [MI]; (-)-GASTRODIN; Gastrodin,(S); gastrodine; 5YS9U2W3RQ; Gastrodin; (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[4-(hydroxymethyl)phenoxy]tetrahydropyran-3,4,5-triol; (2R,3S,4S,5R,6S)-2-methylol-6-(4-methylolphenoxy)tetrahydropyran-3,4,5-triol; ZINC03881790; 62499-27-8; BB_NC-1038; NCGC00346601-02_C13H18O7_beta-D-Glucopyranoside, 4-(hydroxymethyl)phenyl; 2-(hydroxymethyl)-6-[4-(hydroxymethyl)phenoxy]oxane-3,4,5-triol; 4-(beta-D-Glucopyranosyloxy) benzyl alcohol



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

33 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Wensheng Wang, Yu Wang, Fengjie Wang, Guangjing Xie, Shangzhi Liu, Zefei Li, Ping Wang, Junfeng Liu, Li Lin. Gastrodin regulates the TLR4/TRAF6/NF-κB pathway to reduce neuroinflammation and microglial activation in an AD model. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155518. doi: 10.1016/j.phymed.2024.155518. [PMID: 38552431]
  • Yanan Zhao, Shaokun Qin, Zixian Yang, Ye Lu, Zongmin Ma, Xin Ping, Guoqiang Sun, Lin Pei. Gastrodin ameliorates depressive-like behaviors via modulating gut microbiota in CUMS-induced mice. Behavioural brain research. 2024 May; 465(?):114968. doi: 10.1016/j.bbr.2024.114968. [PMID: 38521360]
  • Yang Gu, Yaru Jiang, Changfan Li, Jiang Zhu, Xueyao Lu, Jianyue Ge, Mengchen Hu, Jieying Deng, Jingbo Ma, Zhiliang Yang, Xiaoman Sun, Feng Xue, Guocheng Du, Peng Xu, He Huang. High titer production of gastrodin enabled by systematic refactoring of yeast genome and an antisense-transcriptional regulation toolkit. Metabolic engineering. 2024 Mar; 82(?):250-261. doi: 10.1016/j.ymben.2024.02.016. [PMID: 38428728]
  • Yulin Wang, Mengting Bai, Xian Wang, Zhaolei Peng, Chunyan Cai, Jingjing Xi, Chunmei Yan, Jia Luo, Xiaofang Li. Gastrodin: a comprehensive pharmacological review. Naunyn-Schmiedeberg's archives of pharmacology. 2024 Jan; ?(?):. doi: 10.1007/s00210-023-02920-9. [PMID: 38165423]
  • Pengfei Tong, Ke Tian, Jiajia Bi, Ruihua Wang, Zhengfeng Wang. Gastrodin alleviates premature senescence of vascular endothelial cells by enhancing the Nrf2/HO-1 signalling pathway. Journal of cellular and molecular medicine. 2023 Dec; ?(?):. doi: 10.1111/jcmm.18089. [PMID: 38146239]
  • Chao Ma, Chunran Zhu, Yajun Zhang, Mei Yu, Yizhi Song, Yulong Chong, Yan Yang, Chan Zhu, Yucui Jiang, Changming Wang, Shuo Cheng, Keke Jia, Guang Yu, Jia Li, Zongxiang Tang. Gastrodin alleviates NTG-induced migraine-like pain via inhibiting succinate/HIF-1α/TRPM2 signaling pathway in trigeminal ganglion. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Dec; 125(?):155266. doi: 10.1016/j.phymed.2023.155266. [PMID: 38241917]
  • Zhi Guo, Xuan Yang, Meizhu Wu, Aling Shen, Jiapeng Li, Xiuli Zhang, Ying Cheng, Qiurong Xie, Jun Peng. Gastrodin attenuates angiotensin II-induced vascular contraction and MLCK/p-MLC2 pathway activation. Pharmaceutical biology. 2023 Dec; 61(1):858-867. doi: 10.1080/13880209.2023.2207591. [PMID: 37211627]
  • Cai-Wei Qiu, Bo Chen, Hui-Feng Zhu, Ying-Lan Liang, Lin-Shen Mao. Gastrodin alleviates cisplatin nephrotoxicity by inhibiting ferroptosis via the SIRT1/FOXO3A/GPX4 signaling pathway. Journal of ethnopharmacology. 2023 Oct; ?(?):117282. doi: 10.1016/j.jep.2023.117282. [PMID: 37802374]
  • Honghua Zhang, Yunting Sun, Yuqing Zou, Cheng Chen, Shuling Wang. Stigmasterol and gastrodin, two major components of banxia-baizhu-tianma decoction, alleviated the excessive phlegm-dampness hypertension by reducing lipid accumulation. Journal of ethnopharmacology. 2023 Sep; 319(Pt 2):117193. doi: 10.1016/j.jep.2023.117193. [PMID: 37726069]
  • Zhi-Hao Mu, Zhi-Min Zhao, Su-Su Yang, Lei Zhou, Yi-Dan Liu, Zhong-Yi Qian, Xin-Jie Liu, Peng-Chao Zhao, Ren-Bo Tang, Jia-Yin Li, Jing-Yao Zeng, Zhi-Hong Yang, Yong-Hua Ruan, Ying Zhang, Yue-Qin Zeng, Ying-Ying Zou. Gastrodin ameliorates cognitive dysfunction in diabetes by inhibiting PAK2 phosphorylation. Aging. 2023 Aug; 15(?):. doi: 10.18632/aging.204970. [PMID: 37610708]
  • Yinan Nan, Wenhao Zhu, Bin Zhu, Shaoqing Wang. Gastrodin facilitates recovery of neurological function of MCAO rats through upregulating miR-20a-5p/XIAP pathway via exosome. Neuroreport. 2023 Aug; ?(?):. doi: 10.1097/wnr.0000000000001942. [PMID: 37556588]
  • Aling Shen, Meizhu Wu, Farman Ali, Zhi Guo, Yi Fang, Yuting Zhou, Siyu Zhang, Wenqiang Zhang, Ying Wen, Min Yu, Jun Peng, Keji Chen. Based on network pharmacology, gastrodin attenuates hypertension-induced vascular smooth muscle cell proliferation and PI3K/AKT pathway activation. Scientific reports. 2023 07; 13(1):12140. doi: 10.1038/s41598-023-39202-6. [PMID: 37495624]
  • Baolin Huang, Zimin Lin, Zhenzhen Chen, Jiasheng Chen, Birui Shi, Jingjing Jia, Yuan Li, Yueqing Pan, Yuntao Liang, Zheng Cai. Strain differences in the drug transport capacity of intestinal glucose transporters in Sprague-Dawley versus Wistar rats, C57BL/6J versus Kunming mice. International journal of pharmaceutics. 2023 Jun; 640(?):123000. doi: 10.1016/j.ijpharm.2023.123000. [PMID: 37254285]
  • Fernanda L B Mügge, Cheul Muu Sim, Bernd Honermeier, Gertrud E Morlock. Bioactivity Profiling and Quantification of Gastrodin in Gastrodia elata Cultivated in the Field versus Facility via Hyphenated High-Performance Thin-Layer Chromatography. International journal of molecular sciences. 2023 Jun; 24(12):. doi: 10.3390/ijms24129936. [PMID: 37373083]
  • Sha Wu, Rong Huang, Ruiqin Zhang, Chuang Xiao, Lueli Wang, Min Luo, Na Song, Jie Zhang, Fang Yang, Xuan Liu, Weimin Yang. Gastrodin and Gastrodigenin Improve Energy Metabolism Disorders and Mitochondrial Dysfunction to Antagonize Vascular Dementia. Molecules (Basel, Switzerland). 2023 Mar; 28(6):. doi: 10.3390/molecules28062598. [PMID: 36985572]
  • Jinqiang Zhang, Liangyuan Li, Qin Liu, Zhihuang Zhao, Dapeng Su, Chenghong Xiao, Ting Jin, Li Chen, Chunyun Xu, Zili You, Tao Zhou. Gastrodin programs an Arg-1+ microglial phenotype in hippocampus to ameliorate depression- and anxiety-like behaviors via the Nrf2 pathway in mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Feb; 113(?):154725. doi: 10.1016/j.phymed.2023.154725. [PMID: 36867963]
  • Rui Cheng, Tian-Rui Liu, Yang-Hua Li, Jun-Hui Zhou, Yu-Yang Zhao, Yuan Yuan. [Screening of an Armillaria gallica strain for Gastrodia elata cultivation]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Jan; 48(2):374-381. doi: 10.19540/j.cnki.cjcmm.20221014.101. [PMID: 36725227]
  • Dae-Woon Kim, Jong-Kuk Kim, Yoseph Asmelash Gebru, Young-Hoi Kim, Han-Seok Choi, Myung-Kon Kim. Identification of Novel Parishin Compounds from the Twig of Maclura tricuspidata and Comparative Analysis of Parishin Derivatives in Different Parts. Molecules (Basel, Switzerland). 2022 Dec; 28(1):. doi: 10.3390/molecules28010007. [PMID: 36615203]
  • Shuting Xie, Ke Min, Hai Li, Ying Wang, Mincong Liu, Ming Ma, Desheng Zhou, Haijun Tu, Bo Chen. pH as a Key Factor for the Quality Assurance of the Preparation of Gastrodiae Rhizoma Formula Granules. Molecules (Basel, Switzerland). 2022 Nov; 27(22):. doi: 10.3390/molecules27228091. [PMID: 36432193]
  • Zohre Sadeghian, Shahla Eyvari-Brooshghalan, Mohammadmahdi Sabahi, Nahal Nourouzi, Rasool Haddadi. Post treatment with Gastrodin suppresses oxidative stress and attenuates motor disorders following 6-OHDA induced Parkinson disease. Neuroscience letters. 2022 11; 790(?):136884. doi: 10.1016/j.neulet.2022.136884. [PMID: 36162540]
  • Chia-Chih Liao, Huang-Ping Yu, An-Hsun Chou, Hung-Chen Lee, Li-Min Hu, Fu-Chao Liu. Gastrodin Alleviates Acetaminophen-Induced Liver Injury in a Mouse Model Through Inhibiting MAPK and Enhancing Nrf2 Pathways. Inflammation. 2022 Aug; 45(4):1450-1462. doi: 10.1007/s10753-021-01557-1. [PMID: 35474551]
  • Li Yongguang, Wang Xiaowei, Yan Huichao, Zhang Yanxiang. Gastrodin promotes the regeneration of peripheral nerves by regulating miR-497/BDNF axis. BMC complementary medicine and therapies. 2022 Feb; 22(1):45. doi: 10.1186/s12906-021-03483-z. [PMID: 35177060]
  • Li Jiang, Yanling Xiong, Yu Tu, Wentong Zhang, Qiyun Zhang, Peng Nie, Xiaojun Yan, Hongning Liu, Ronghua Liu, Guoliang Xu. Elucidation of the Transport Mechanism of Puerarin and Gastrodin and Their Interaction on the Absorption in a Caco-2 Cell Monolayer Model. Molecules (Basel, Switzerland). 2022 Feb; 27(4):. doi: 10.3390/molecules27041230. [PMID: 35209020]
  • Yi Zheng, Nan Zhang, Fuding Bai. Gastrodin Pretreatment Alleviates Renal Ischemia-Reperfusion Injury. Urologia internationalis. 2022; 106(6):630-637. doi: 10.1159/000520531. [PMID: 35051947]
  • Kaixuan Luo, Yuhong Wang, Wen-Shiang Chen, Xiangjun Feng, Yehui Liao, Shaochun Chen, Yao Liu, Chengde Liao, Moxian Chen, Lijuan Ao. Treatment Combining Focused Ultrasound with Gastrodin Alleviates Memory Deficit and Neuropathology in an Alzheimer's Disease-Like Experimental Mouse Model. Neural plasticity. 2022; 2022(?):5241449. doi: 10.1155/2022/5241449. [PMID: 35069727]
  • Juan Wan, Yanyan Zhang, Diqi Yang, Yongjie Liang, Ling Yang, Sha Hu, Zhen Liu, Qian Fang, Song Tian, Yi Ding. Gastrodin Improves Nonalcoholic Fatty Liver Disease Through Activation of the Adenosine Monophosphate-Activated Protein Kinase Signaling Pathway. Hepatology (Baltimore, Md.). 2021 12; 74(6):3074-3090. doi: 10.1002/hep.32068. [PMID: 34297426]
  • Yu-En Lin, Chin-Hsien Lin, En-Peng Ho, Yi-Ci Ke, Stavroula Petridi, Christopher Jh Elliott, Lee-Yan Sheen, Cheng-Ting Chien. Glial Nrf2 signaling mediates the neuroprotection exerted by Gastrodia elata Blume in Lrrk2-G2019S Parkinson's disease. eLife. 2021 11; 10(?):. doi: 10.7554/elife.73753. [PMID: 34779396]
  • Hsiao-Chien Ting, Hui-I Yang, Horng-Jyh Harn, Ing-Ming Chiu, Hong-Lin Su, Xiang Li, Mei-Fang Chen, Tsung-Jung Ho, Ching-Ann Liu, Yung-Jen Tsai, Tzyy-Wen Chiou, Shinn-Zong Lin, Chia-Yu Chang. Coactivation of GSK3β and IGF-1 Attenuates Amyotrophic Lateral Sclerosis Nerve Fiber Cytopathies in SOD1 Mutant Patient-Derived Motor Neurons. Cells. 2021 10; 10(10):. doi: 10.3390/cells10102773. [PMID: 34685754]
  • Jianzheng He, Xu Li, Shipei Yang, Yaling Li, Xingyao Lin, Minghui Xiu, Xuexiang Li, Yongqi Liu. Gastrodin extends the lifespan and protects against neurodegeneration in the Drosophila PINK1 model of Parkinson's disease. Food & function. 2021 Sep; 12(17):7816-7824. doi: 10.1039/d1fo00847a. [PMID: 34232246]
  • Kunkun Guo, Xin Wang, Baolin Huang, Xiaoyun Wu, Shuimei Shen, Zimin Lin, Jie Zhao, Zheng Cai. Comparative study on the intestinal absorption of three gastrodin analogues via the glucose transport pathway. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2021 Aug; 163(?):105839. doi: 10.1016/j.ejps.2021.105839. [PMID: 33852971]
  • Heng-Sheng Zhang, Bo Ouyang, Xiong-Ying Ji, Mei-Fang Liu. Gastrodin Alleviates Cerebral Ischaemia/Reperfusion Injury by Inhibiting Pyroptosis by Regulating the lncRNA NEAT1/miR-22-3p Axis. Neurochemical research. 2021 Jul; 46(7):1747-1758. doi: 10.1007/s11064-021-03285-2. [PMID: 33839999]
  • Fei-Yu Liu, Jing Wen, Jiong Hou, Si-Qi Zhang, Chun-Bin Sun, Luo-Chuan Zhou, Wen Yin, Wen-Lin Pang, Cui Wang, Yi Ying, Si-Si Han, Jin-Yuan Yan, Chen-Xi Li, Jia-Li Yuan, Hai-Jing Xing, Zhong-Shan Yang. Gastrodia remodels intestinal microflora to suppress inflammation in mice with early atherosclerosis. International immunopharmacology. 2021 Jul; 96(?):107758. doi: 10.1016/j.intimp.2021.107758. [PMID: 34162137]
  • Jun Tao, Ping Yang, Liqiu Xie, Yuwei Pu, Jiazhi Guo, Jianlin Jiao, Lin Sun, Di Lu. Gastrodin induces lysosomal biogenesis and autophagy to prevent the formation of foam cells via AMPK-FoxO1-TFEB signalling axis. Journal of cellular and molecular medicine. 2021 06; 25(12):5769-5781. doi: 10.1111/jcmm.16600. [PMID: 33973365]
  • Chih-Sheng Yang, Sheng-Chun Chiu, Ping-Yen Liu, Sheng-Nan Wu, Ming-Chi Lai, Chin-Wei Huang. Gastrodin alleviates seizure severity and neuronal excitotoxicities in the rat lithium-pilocarpine model of temporal lobe epilepsy via enhancing GABAergic transmission. Journal of ethnopharmacology. 2021 Apr; 269(?):113751. doi: 10.1016/j.jep.2020.113751. [PMID: 33359863]
  • Yu-Lin Qiao, Wen-Qiang Xiang, Fang Liu, Sheng Jin. Clinical therapeutic effects of gastrodin in combination with betahistine on vertigo: A protocol for systematic review and meta-analysis. Medicine. 2021 Mar; 100(10):e23825. doi: 10.1097/md.0000000000023825. [PMID: 33725810]
  • Yuan Wang, Lin Zhao, An-Yuan Li. Gastrodin - A potential drug used for the treatment of Tourette Syndrome. Journal of pharmacological sciences. 2021 Mar; 145(3):289-295. doi: 10.1016/j.jphs.2021.01.005. [PMID: 33602510]
  • Xiaoliang Wang, Lihai Chen, Yajie Xu, Wanling Wang, Youran Wang, Zhiyuan Zhang, Jing Zheng, Hongguang Bao. Gastrodin alleviates perioperative neurocognitive dysfunction of aged mice by suppressing neuroinflammation. European journal of pharmacology. 2021 Feb; 892(?):173734. doi: 10.1016/j.ejphar.2020.173734. [PMID: 33220272]
  • Xu Li, Tian-Jiao Xu, Li-Kun Liu, Miao-Xian Dong. [Antioxidant mechanism of gastrodin combined with isorhynchophylline in inhibiting MPP~+-induced apoptosis of PC12 cells]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2021 Jan; 46(2):420-425. doi: 10.19540/j.cnki.cjcmm.20201009.401. [PMID: 33645131]
  • Bingjie Qin, Ni Luo, Yuxing Li, Denghui Gong, Jun Zheng, Xiao Tan, Weihong Zheng. Protective effect of gastrodin on peripheral neuropathy induced by anti-tumor treatment with vincristine in rat models. Drug and chemical toxicology. 2021 Jan; 44(1):84-91. doi: 10.1080/01480545.2018.1547739. [PMID: 30554535]
  • Hua Yin, Tiandong Hu, Yibin Zhuang, Tao Liu. Metabolic engineering of Saccharomyces cerevisiae for high-level production of gastrodin from glucose. Microbial cell factories. 2020 Nov; 19(1):218. doi: 10.1186/s12934-020-01476-0. [PMID: 33243241]
  • Qiao-Qiao Cheng, Yu-Wei Wan, Wei-Min Yang, Meng-Hua Tian, Yu-Chuan Wang, Hai-Yan He, Wei-Dong Zhang, Xuan Liu. Gastrodin protects H9c2 cardiomyocytes against oxidative injury by ameliorating imbalanced mitochondrial dynamics and mitochondrial dysfunction. Acta pharmacologica Sinica. 2020 Oct; 41(10):1314-1327. doi: 10.1038/s41401-020-0382-x. [PMID: 32203078]
  • C-L Ma, L Li, G-M Yang, Z-B Zhang, Y-N Zhao, X-F Zeng, D-X Zhang, Y Yu, Z-J Shi, Q-W Yan, L-H Li, S-J Hong. Neuroprotective effect of gastrodin in methamphetamine-induced apoptosis through regulating cAMP/PKA/CREB pathway in cortical neuron. Human & experimental toxicology. 2020 Aug; 39(8):1118-1129. doi: 10.1177/0960327120911438. [PMID: 32162539]
  • Jie-Qiong Ma, Yun-Zhi Sun, Qing-Lei Ming, Zhi-Kai Tian, Yu-Jia Zhang, Chan-Min Liu. Effects of gastrodin against carbon tetrachloride induced kidney inflammation and fibrosis in mice associated with the AMPK/Nrf2/HMGB1 pathway. Food & function. 2020 May; 11(5):4615-4624. doi: 10.1039/d0fo00711k. [PMID: 32400831]
  • Ting Jiang, Hui Cheng, Jingjing Su, Xuncui Wang, Qiaoxue Wang, Jun Chu, Qinglin Li. Gastrodin protects against glutamate-induced ferroptosis in HT-22 cells through Nrf2/HO-1 signaling pathway. Toxicology in vitro : an international journal published in association with BIBRA. 2020 Feb; 62(?):104715. doi: 10.1016/j.tiv.2019.104715. [PMID: 31698019]
  • Yahui Mi, Siyu Guo, Huan Cheng, Mingping Liu, Pinqing Wei, Meijing Wang, Yukang Mao, Guohan Ke. Pharmacokinetic comparative study of tetramethylpyrazine and ferulic acid and their compatibility with different concentration of gastrodin and gastrodigenin on blood-stasis migraine model by blood-brain microdialysis method. Journal of pharmaceutical and biomedical analysis. 2020 Jan; 177(?):112885. doi: 10.1016/j.jpba.2019.112885. [PMID: 31563759]
  • Zhi-Long Zhang, Yu-Gang Gao, Pu Zang, Pei-Pei Gu, Yan Zhao, Zhong-Mei He, Hong-Yan Zhu. [Research progress on mechanism of gastrodin and p-hydroxybenzyl alcohol on central nervous system]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2020 Jan; 45(2):312-320. doi: 10.19540/j.cnki.cjcmm.20190730.401. [PMID: 32237313]
  • Bo Yuan, Hanfei Huang, Siming Qu, Hongbin Zhang, Jie Lin, Li Jin, Shikun Yang, Zhong Zeng. Gastrodin Pretreatment Protects Liver Against Ischemia-Reperfusion Injury via Activation of the Nrf2/HO-1 Pathway. The American journal of Chinese medicine. 2020; 48(5):1159-1178. doi: 10.1142/s0192415x20500573. [PMID: 32668973]
  • Ting Jiang, Jun Chu, Hejuntao Chen, Hui Cheng, Jingjing Su, Xuncui Wang, Yin Cao, Shasha Tian, Qinglin Li. Gastrodin Inhibits H2O2-Induced Ferroptosis through Its Antioxidative Effect in Rat Glioma Cell Line C6. Biological & pharmaceutical bulletin. 2020; 43(3):480-487. doi: 10.1248/bpb.b19-00824. [PMID: 32115506]
  • Rui Shi, Chang-Bo Zheng, Hongyan Wang, Qiang Rao, Tingyan Du, Chunyun Bai, Chuang Xiao, Zelan Dai, Changhong Zhang, Chen Chen, Xian Li, Menghua Tian, Xianlun Yu, Baixi Ji, Zhiying Weng, Weimin Yang. Gastrodin Alleviates Vascular Dementia in a 2-VO-Vascular Dementia Rat Model by Altering Amyloid and Tau Levels. Pharmacology. 2020; 105(7-8):386-396. doi: 10.1159/000504056. [PMID: 31752010]
  • Chih-Sheng Yang, Ming-Chi Lai, Ping-Yen Liu, Yi-Ching Lo, Chin-Wei Huang, Sheng-Nan Wu. Characterization of the Inhibitory Effect of Gastrodigenin and Gastrodin on M-type K+ Currents in Pituitary Cells and Hippocampal Neurons. International journal of molecular sciences. 2019 Dec; 21(1):. doi: 10.3390/ijms21010117. [PMID: 31877994]
  • Heng-Sheng Zhang, Mei-Fang Liu, Xiong-Ying Ji, Chang-Rong Jiang, Zi-Li Li, Bo OuYang. Gastrodin combined with rhynchophylline inhibits cerebral ischaemia-induced inflammasome activation via upregulating miR-21-5p and miR-331-5p. Life sciences. 2019 Dec; 239(?):116935. doi: 10.1016/j.lfs.2019.116935. [PMID: 31610203]
  • Hongyan Long, Jie Ruan, Mengjiao Zhang, Chunyan Wang, Yaruo Huang. Gastrodin alleviates Tourette syndrome via Nrf-2/HO-1/HMGB1/NF-кB pathway. Journal of biochemical and molecular toxicology. 2019 Oct; 33(10):e22389. doi: 10.1002/jbt.22389. [PMID: 31468582]
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