Digitoxin (BioDeep_00000000116)

 

Secondary id: BioDeep_00000398598

human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs natural product


代谢物信息卡片


3-[(3S,5R,8R,9S,10S,13R,14S,17R)-3-[(2R,4S,5S,6R)-5-[(2S,4S,5S,6R)-5-[(2S,4S,5S,6R)-4,5-dihydroxy-6-methyl-tetrahydropyran-2-yl]oxy-4-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-4-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-14-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one

化学式: C41H64O13 (764.4347)
中文名称: 洋地黄毒苷, 洋地黄毒甙
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 58.99%

分子结构信息

SMILES: C1[C@@]2(C)[C@]([H])(CC[C@]3([H])[C@]2([H])CC[C@@]2(C)[C@]3(O)CC[C@]2([H])C2=CC(=O)OC2)C[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@H](O)[C@H](O[C@@H]4O[C@H](C)[C@@H](O)[C@@H](O)C4)[C@@H](C)O3)[C@@H](O)C2)C1
InChI: InChI=1S/C41H64O13/c1-20-36(46)29(42)16-34(49-20)53-38-22(3)51-35(18-31(38)44)54-37-21(2)50-33(17-30(37)43)52-25-8-11-39(4)24(15-25)6-7-28-27(39)9-12-40(5)26(10-13-41(28,40)47)23-14-32(45)48-19-23/h14,20-22,24-31,33-38,42-44,46-47H,6-13,15-19H2,1-5H3/t20-,21-,22-,24-,25+,26-,27+,28-,29+,30+,31+,33+,34+,35+,36-,37-,38-,39+,40-,41+/m1/s1

描述信息

Digitoxin appears as odorless white or pale buff microcrystalline powder. Used as a cardiotonic drug. (EPA, 1998)
Digitoxin is a cardenolide glycoside in which the 3beta-hydroxy group of digitoxigenin carries a 2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl trisaccharide chain. It has a role as an EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor. It is functionally related to a digitoxigenin. It is a conjugate acid of a digitoxin(1-).
A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665)
Digitoxin is a natural product found in Digitalis obscura, Digitalis parviflora, and other organisms with data available.
Digitoxin is a lipid soluble cardiac glycoside that inhibits the plasma membrane sodium potassium ATPase, leading to increased intracellular sodium and calcium levels and decreased intracellular potassium levels. In studies increased intracellular calcium precedes cell death and decreased intracellular potassium increase caspase activation and DNA fragmentation, causing apoptosis and inhibition of cancer cell growth. (NCI)
Digitoxin is only found in individuals that have used or taken this drug. It is a cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665)Digitoxin inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). Digitoxin also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential.
A cardiac glycoside sometimes used in place of DIGOXIN. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665)
See also: Acetyldigitoxin (is active moiety of).
Digitoxin, also known as crystodigin or digitoxoside, belongs to cardenolide glycosides and derivatives class of compounds. Those are compounds containing a carbohydrate glycosidically bound to the cardenolide moiety. Thus, digitoxin is considered to be a sterol lipid molecule. Digitoxin is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Digitoxin can be synthesized from digitoxigenin. Digitoxin can also be synthesized into 3-O-acetyldigitoxin. Digitoxin can be found in common bean, which makes digitoxin a potential biomarker for the consumption of this food product. Digitoxin can be found primarily in blood and urine. Digitoxin is a non-carcinogenic (not listed by IARC) potentially toxic compound. Digitoxin is a drug which is used for the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure. Digitoxin is a cardiac glycoside. It is a phytosteroid and is similar in structure and effects to digoxin (though the effects are longer-lasting). Unlike digoxin (which is eliminated from the body via the kidneys), it is eliminated via the liver, so could be used in patients with poor or erratic kidney function. However, it is now rarely used in current Western medical practice. While several controlled trials have shown digoxin to be effective in a proportion of patients treated for heart failure, the evidence base for digitoxin is not as strong, although it is presumed to be similarly effective . Digitoxin exhibits similar toxic effects to the more-commonly used digoxin, namely: anorexia, nausea, vomiting, diarrhoea, confusion, visual disturbances, and cardiac arrhythmias (DrugBank). Digitoxin inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). Digitoxin also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential (T3DB).
Digitoxin is a cardenolide glycoside in which the 3beta-hydroxy group of digitoxigenin carries a 2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl trisaccharide chain. It has a role as an EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor. It derives from a digitoxigenin. It is a conjugate acid of a digitoxin(1-). Digitoxin appears as odorless white or pale buff microcrystalline powder. It is a cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. Digitoxin inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). Digitoxin also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential.
C - Cardiovascular system > C01 - Cardiac therapy > C01A - Cardiac glycosides > C01AA - Digitalis glycosides
D020011 - Protective Agents > D002316 - Cardiotonic Agents > D004071 - Digitalis Glycosides
D020011 - Protective Agents > D002316 - Cardiotonic Agents > D002301 - Cardiac Glycosides
C78274 - Agent Affecting Cardiovascular System > C78322 - Cardiotonic Agent
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D004791 - Enzyme Inhibitors
C471 - Enzyme Inhibitor
Digitoxin is a potent Na+/K+-ATPase inhibitor with an EC50 value of 0.78 μM.
Digitoxin is a potent Na+/K+-ATPase inhibitor with an EC50 value of 0.78 μM.

同义名列表

142 个代谢物同义名

3-[(3S,5R,8R,9S,10S,13R,14S,17R)-3-[(2R,4S,5S,6R)-5-[(2S,4S,5S,6R)-5-[(2S,4S,5S,6R)-4,5-dihydroxy-6-methyl-tetrahydropyran-2-yl]oxy-4-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-4-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-14-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one; 4-((3S,5R,8R,9S,10S,13R,14S,17R)-3-(((2R,4S,5S,6R)-5-(((2S,4S,5S,6R)-5-(((2S,4S,5S,6R)-4,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)furan-2(5H)-one; 3-[(3S,5R,8R,9S,10S,13R,14S,17R)-3-[(2R,4S,5S,6R)-5-[(2S,4S,5S,6R)-5-[(2S,4S,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyloxan-2-yl]oxy-14-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one; 4-[(3S,5R,8R,9S,10S,13R,14S,17R)-3-[(2R,4S,5S,6R)-5-[(2S,4S,5S,6R)-5-[(2S,4S,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyloxan-2-yl]oxy-14-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-5H-furan-2-one; 4-[(1R,3aS,3bR,5aR,7S,9aS,9bS,11aR)-7-{[(2R,4S,5S,6R)-5-{[(2S,4S,5S,6R)-5-{[(2S,4S,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy}-4-hydroxy-6-methyloxan-2-yl]oxy}-4-hydroxy-6-methyloxan-2-yl]oxy}-3a-hydroxy-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]-2,5-dihydrofuran-2-one; 4-[(1S,2S,5S,7R,10R,11S,14R,15R)-5-{[(2R,4S,5S,6R)-5-{[(2S,4S,5S,6R)-5-{[(2S,4S,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy}-4-hydroxy-6-methyloxan-2-yl]oxy}-4-hydroxy-6-methyloxan-2-yl]oxy}-11-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-yl]-2,5-dihydrofuran-2-one; 4-[(1S,2S,5S,7R,10R,11S,14R,15R)-5-{[(2R,4S,5S,6R)-5-{[(2S,4S,5S,6R)-5-{[(2S,4S,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy}-4-hydroxy-6-methyloxan-2-yl]oxy}-4-hydroxy-6-methyloxan-2-yl]oxy}-11-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-yl]-5H-furan-2-one; 4-((1S,2S,5S,11S,7R,10R,14R,15R)-5-{5-[5-((2S,4S,5S,6R)-4,5-dihydroxy-6-methyl (2H-3,4,5,6-tetrahydropyran-2-yloxy))(4S,5S,2R,6R)-4-hydroxy-6-methyl(2H-3,4,5 ,6-tetrahydropyran-2-yloxy)](4S,5S,2R,6R)-4-hydroxy-6-methyl(2H-3,4,5,6-tetrah ydropyran-2-yloxy); Card-20(22)-enolide, 3-((O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1.fwdarw.4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1.fwdarw.4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-14-hydroxy-, (3beta,5beta)-; CARD-20(22)-ENOLIDE, 3-((O-2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYL-(1->4)-O-2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYL-(1->4)-2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYL)OXY)-14-HYDROXY-, (3.BETA.,5.BETA.)-; (3.BETA.,5.BETA.)-3-((O-2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYL-(1->4)-O-2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYL-(1->4)-2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYL)OXY)-14-HYDROXYCARD-20(22)-ENOLIDE; Card-20(22)-enolide, 3-((O-2,6-dideoxy-.beta.-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-.beta.-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-.beta.-D-ribo-hexopyranosyl)oxy)-14-hydroxy-, (3beta,5beta)-; Card-20(22)-enolide, 3-((O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-14-hydroxy-, (3beta,5beta)-; Card-20(22)-enolide, 3-((O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-14-hydroxy-, (3beta,5beta)-; 3.BETA.-((2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYL-(1->4)-2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYL-(1->4)-2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYL)OXY)-14-HYDROXY-5.BETA.-CARD-20(22)-ENOLIDE; Card-20(22)-enolide, 3-((O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-14-hydroxy, (3beta,5beta)-; (3beta,5beta)-3-((O-2,6-Dideoxy-beta-D-ribohexopyranosyl-(1-4)-O-2,6-dideoxy-bet a-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-14-hydro xycard-20(22)- enolide; (3beta,5beta)-3-((O-2,6-DIDEOXY-beta-D-RIBO-HEXOPYRANOSYL-(1->4)-O-2,6-DIDEOXY-beta-D-RIBO-HEXOPYRANOSYL-(1->4)-2,6-DIDEOXY-beta-D-RIBO-HEXOPYRANOSYL)OXY)-14-HYDROXYCARD-20(22)-ENOLIDE; (3beta,5beta)-3-((O-2,6-Dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-14-hydroxycard-20(22)-enolide; 3beta-(2,6-Dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyloxy)-14-hydroxy-5beta,14beta-card-20(22)-enolide; (3beta,5beta)-3-{[2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-14-hydroxycard-20(22)-enolide; 3beta-((2,6-DIDEOXY-beta-D-RIBO-HEXOPYRANOSYL-(1->4)-2,6-DIDEOXY-beta-D-RIBO-HEXOPYRANOSYL-(1->4)-2,6-DIDEOXY-beta-D-RIBO-HEXOPYRANOSYL)OXY)-14-HYDROXY-5beta-CARD-20(22)-ENOLIDE; 3beta-[2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyloxy]-14-hydroxy-5beta-card-20(22)-enolide; 3beta-(2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyloxy)-14-hydroxy-5beta-card-20(22)-enolide; 3beta-[2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyloxy]-14-hydroxy-5beta-card-20(22)-enolide; CARD-20(22)-ENOLIDE, 3-((O-2,6-DIDEOXY-BETA-D-RIBO-HEXOPYRANOSYL-(HEXOPYRANOSYL-(1-4)-2,6-DIDEOXY-BETA-D-RIBO-HEXOPYRANOSYL)OXY)-14-HYDROXY-,(3BETA, 5BETA)-; (3.BETA.,5.BETA.)-3-((O-2,6-DIDEOXY-.BETA.-D-RIBO-HEXAPYRANOSYL-(1->4)-2,6-DIDEOXY-.BETA.-D-RIBO-HEXOPYRANOSYL)OXY)-14-HYDROXYCARD-20(22)-ENOLIDE; (3beta,5beta)-3-((O-2,6-DIDEOXY-beta-D-RIBO-HEXAPYRANOSYL-(1->4)-2,6-DIDEOXY-beta-D-RIBO-HEXOPYRANOSYL)OXY)-14-HYDROXYCARD-20(22)-ENOLIDE; Digitoxin, United States Pharmacopeia (USP) Reference Standard; Digitoxin, European Pharmacopoeia (EP) Reference Standard; Digitoxin, British Pharmacopoeia (BP) Reference Standard; Digitoxigenin-tridigitoxosid [German]; DIGOXIN IMPURITY A [EP IMPURITY]; DIGOXIN IMPURITY A (EP IMPURITY); Digitoxin, >=92\\% (HPLC), powder; Digitoxigenin tridigitoxoside; Digitoxigenin-tridigitoxosid; WDJUZGPOPHTGOT-XUDUSOBPSA-N; Digitoxin [USP:INN:BAN:JAN]; Digitoxin (USP:INN:BAN:JAN); DIGITOXINUM [WHO-IP LATIN]; Tri-digitoxoside [German]; DIGITOXIN (USP MONOGRAPH); DIGITOXIN [USP MONOGRAPH]; DIGITOXIN [USP IMPURITY]; Digitoxina (INN-Spanish); DIGITOXIN [EP MONOGRAPH]; DIGITOXIN (USP IMPURITY); DIGITOXIN (EP MONOGRAPH); Digitoxina [INN-Spanish]; DIGITOXIN [ORANGE BOOK]; Digitoxine [INN-French]; Digitoxinum (INN-Latin); Mono-digitoxid [German]; Digitaline cristallisee; Digitoxin (JAN/USP/INN); Digitoxinum [INN-Latin]; Digitoxine (INN-French); Purodigin, crystalline; Digitoxin for LC assay; Digitalin, crystalline; Nativelle, Digitaline; Crystalline digitalin; Digitaline Nativelle; DIGITOXIN [WHO-IP]; DIGITOXIN [WHO-DD]; DIGITOXIN [USP-RS]; DIGITOXINUM [HPUS]; Digitossina [DCIT]; DIGITOXIN (USP-RS); DIGITOXIN [VANDF]; Bürger, Digitoxin; Didier, Digitoxin; Digitoxin Didier; DIGITOXIN [HSDB]; Digitoxin Bürger; Monodigitoxoside; Tri-digitoxoside; Crystodigin (TN); Digitoxin-Philo; DIGITOXIN [JAN]; UNII-E90NZP2L9U; Digitoxin Philo; DIGITOXIN [INN]; Mono-glycocard; Mono-digitoxid; Tox21_111659_1; DigitoXin, USP; DIGITOXIN [MI]; AWD, Digitoxin; Digitophyllin; Digitoxosidum; Digitoxin AWD; MEGxp0_001901; ACon0_000319; Tox21_302269; Tox21_111659; ACon1_000610; Digitoxoside; Cristapurat; Crystodigin; CAS-71-63-6; SMP1_000096; Digitossina; Asthenthilo; Digitoxinum; Glucodigin; Digitoksin; Carditalin; Carditoxin; E90NZP2L9U; Glucokinin; Cardidigin; Digitoksim; Digitoxine; Digitaline; Digitoxina; Coramedan; Digimerck; Lanatoxin; Purodigin; Digitoxin; Digisidin; Digitalis; Digophton; Digipural; tradigal; Unidigin; Digitrin; Digilong; Myodigin; Tardigal; Cardigin; Acedoxin; Purpurid; De-Tone; Ditaven; Natigal; Digimed; Digicor; C01AA04; Digitoxin



数据库引用编号

29 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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80 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 ABCB1, AKT1, ALB, AXIN2, BCL2, CASP3, CASP9, CDK1, EGFR, NFKB1, PIK3CA, POMC, PTK2
Peripheral membrane protein 2 CYP11A1, PTK2
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 3 BCL2, CDK1, EGFR
Mitochondrion membrane 1 CYP11A1
Nucleus 10 AKT1, ALB, AXIN2, BCL2, CASP3, CASP9, CDK1, EGFR, NFKB1, PTK2
cytosol 10 AKT1, ALB, AXIN2, BCL2, CASP3, CASP9, CDK1, NFKB1, PIK3CA, PTK2
dendrite 1 KCNB1
centrosome 4 ALB, AXIN2, CDK1, PTK2
nucleoplasm 5 AKT1, ATP2B1, CASP3, CDK1, NFKB1
Cell membrane 7 ABCB1, AKT1, ATP2B1, EGFR, KCNB1, PTK2, TNF
Cytoplasmic side 1 PTK2
lamellipodium 2 AKT1, PIK3CA
ruffle membrane 1 EGFR
Cell projection, axon 1 KCNB1
Early endosome membrane 1 EGFR
Multi-pass membrane protein 3 ABCB1, ATP2B1, KCNB1
Synapse 2 ATP2B1, KCNB1
cell cortex 2 AKT1, PTK2
cell junction 1 EGFR
cell surface 4 ABCB1, EGFR, KCNB1, TNF
glutamatergic synapse 4 AKT1, ATP2B1, CASP3, EGFR
Golgi apparatus 1 ALB
Golgi membrane 2 EGFR, INS
mitochondrial inner membrane 1 CYP11A1
neuronal cell body 2 CASP3, TNF
postsynapse 1 AKT1
presynaptic membrane 1 ATP2B1
sarcolemma 1 KCNB1
endosome 1 EGFR
plasma membrane 9 ABCB1, AKT1, ATP2B1, AXIN2, EGFR, KCNB1, PIK3CA, PTK2, TNF
synaptic vesicle membrane 1 ATP2B1
Membrane 8 ABCB1, AKT1, ATP2B1, BCL2, CDK1, CYP11A1, EGFR, KCNB1
apical plasma membrane 3 ABCB1, EGFR, KCNB1
axon 1 KCNB1
basolateral plasma membrane 2 ATP2B1, EGFR
extracellular exosome 4 ABCB1, ALB, ATP2B1, CDK1
endoplasmic reticulum 2 ALB, BCL2
extracellular space 7 ALB, CXCL8, EGFR, IL6, INS, POMC, TNF
perinuclear region of cytoplasm 4 EGFR, KCNB1, PIK3CA, PTK2
intercalated disc 1 PIK3CA
mitochondrion 5 BCL2, CASP9, CDK1, CYP11A1, NFKB1
protein-containing complex 5 AKT1, ALB, BCL2, CASP9, EGFR
intracellular membrane-bounded organelle 2 ATP2B1, PTK2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 EGFR
Secreted 5 ALB, CXCL8, IL6, INS, POMC
extracellular region 7 ALB, CXCL8, IL6, INS, NFKB1, POMC, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
neuronal cell body membrane 1 KCNB1
mitochondrial matrix 2 CDK1, CYP11A1
anchoring junction 2 ALB, PTK2
transcription regulator complex 1 NFKB1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 CDK1, PTK2
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, EGFR
external side of plasma membrane 1 TNF
dendritic spine 1 PTK2
perikaryon 1 KCNB1
beta-catenin destruction complex 1 AXIN2
microtubule cytoskeleton 1 AKT1
midbody 1 CDK1
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
postsynaptic membrane 1 KCNB1
Apical cell membrane 1 ABCB1
Cell membrane, sarcolemma 1 KCNB1
Cytoplasm, perinuclear region 1 PTK2
Mitochondrion inner membrane 1 CYP11A1
Membrane raft 2 EGFR, TNF
pore complex 1 BCL2
Cell junction, focal adhesion 1 PTK2
Cytoplasm, cytoskeleton 1 PTK2
focal adhesion 2 EGFR, PTK2
spindle 1 AKT1
intracellular vesicle 1 EGFR
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 1 POMC
lateral plasma membrane 2 ATP2B1, KCNB1
Postsynaptic cell membrane 1 KCNB1
receptor complex 1 EGFR
ciliary basal body 3 AKT1, ALB, PTK2
chromatin 1 NFKB1
cell projection 2 ATP2B1, PTK2
phagocytic cup 1 TNF
mitotic spindle 1 CDK1
cytoskeleton 1 PTK2
Cytoplasm, cytoskeleton, cilium basal body 1 PTK2
centriole 1 ALB
spindle pole 1 ALB
chromosome, telomeric region 1 CDK1
Cytoplasm, cell cortex 1 PTK2
blood microparticle 1 ALB
Basolateral cell membrane 1 ATP2B1
endosome lumen 1 INS
Cell projection, dendrite 1 KCNB1
Presynaptic cell membrane 1 ATP2B1
myelin sheath 1 BCL2
stress fiber 1 PTK2
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
voltage-gated potassium channel complex 1 KCNB1
secretory granule lumen 3 INS, NFKB1, POMC
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 ALB, IL6, INS
platelet alpha granule lumen 1 ALB
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
specific granule lumen 1 NFKB1
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 ATP2B1
apoptosome 1 CASP9
clathrin-coated endocytic vesicle membrane 1 EGFR
Synapse, synaptosome 1 KCNB1
Lateral cell membrane 1 KCNB1
spindle microtubule 1 CDK1
external side of apical plasma membrane 1 ABCB1
death-inducing signaling complex 1 CASP3
postsynaptic specialization membrane 1 KCNB1
dendrite membrane 1 KCNB1
cyclin-dependent protein kinase holoenzyme complex 1 CDK1
cholinergic synapse 1 KCNB1
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
cyclin A1-CDK1 complex 1 CDK1
cyclin A2-CDK1 complex 1 CDK1
cyclin B1-CDK1 complex 1 CDK1
BAD-BCL-2 complex 1 BCL2
proximal dendrite 1 KCNB1
photoreceptor ribbon synapse 1 ATP2B1
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
ciliary transition fiber 1 ALB
caspase complex 1 CASP9
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

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