Flavone (BioDeep_00000000109)

Main id: BioDeep_00001867465

 

human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


InChI=1/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10

化学式: C15H10O2 (222.06807600000002)
中文名称: 黄酮, 黄酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC2OC(C3C=CC=CC=3)=CC(=O)C=2C=C1
InChI: InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H

描述信息

Flavone is the simplest member of the class of flavones that consists of 4H-chromen-4-one bearing a phenyl substituent at position 2. It has a role as a metabolite and a nematicide.
Flavone is a natural product found in Grindelia hirsutula, Asphodeline damascena, and other organisms with data available.
Quercetin is a flavonoid that forms the "backbone" for many other flavonoids, including the citrus flavonoids rutin, hesperidin, naringin and tangeritin. In studies, quercetin is found to be the most active of the flavonoids, and many medicinal plants owe much of their activity to their high quercetin content. Quercetin has demonstrated significant anti-inflammatory activity because of direct inhibition of several initial processes of inflammation. For example, it inhibits both the manufacture and release of histamine and other allergic/inflammatory mediators. In addition, it exerts potent antioxidant activity and vitamin C-sparing action.
Flavone is an endogenous metabolite.
Flavone is an endogenous metabolite.

同义名列表

44 个代谢物同义名

InChI=1/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10; 5-17-10-00552 (Beilstein Handbook Reference); 6CC153EB-39A6-42FC-BE96-C8BF1D585E27; 4H-1-Benzopyran-4-one, 2-phenyl-; 2-Phenyl-4H-1-benzopyran-4-one; 2-Phenyl-.gamma.-benzopyrone; 2-Phenyl-4H-benzopyran-4-one; 2-Phenylbenzo[b]pyran-4-one; 2-phenyl-1-benzopyran-4-one; 2-Phenyl-4H-chromen-4-one #; 2-Phenyl-gamma-benzopyrone; 2-Phenyl-4H-chromen-4-one; 2-Phenyl-4H-chromen-4-on; 2-Phenylbenzopyran-4-one; 2-phenyl-1,4-benzopyrone; 2-Phenyl-chromen-4-one; 2-Phenyl-4-benzopyron; 2-phenylchromen-4-one; 2-phenyl-4H-chromone; flavone, 14C-labeled; 2-Phenyl-4-chromone; Maybridge3_005286; 2-Phenylchromone; Flavone, Flavone; UNII-S2V45N7G3B; Phenylchromone; MEGxp0_001685; Flavone (VAN); FLAVONE [MI]; ICCB2_000263; ACon1_000055; Tox21_202987; Tox21_400059; IDI1_016673; S2V45N7G3B; Cromarile; Chromocor; Asmacoril; Cromaril; Flavone; Flavon; 4hki; FLN; Flavone



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

28 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kazutaka Murayama, Miyuki Kato-Murayama, Toshiaki Hosaka, Naoko Okitsu, Yoshikazu Tanaka, Mikako Shirouzu. Molecular basis of ligand recognition specificity of flavone glucosyltransferases in Nemophila menziesii. Archives of biochemistry and biophysics. 2024 Mar; 753(?):109926. doi: 10.1016/j.abb.2024.109926. [PMID: 38346547]
  • Ting Xu, Yangjun Lv, Yuhan Cui, Dongchen Liu, Tao Xu, Baiyi Lu, Xuan Yang. Properties of Dietary Flavone Glycosides, Aglycones, and Metabolites on the Catalysis of Human Endoplasmic Reticulum Uridine Diphosphate Glucuronosyltransferase 2B7 (UGT2B7). Nutrients. 2023 Nov; 15(23):. doi: 10.3390/nu15234941. [PMID: 38068799]
  • Huixin Tan, Fenghe Wang, Jiahuan Hu, Xiaoyan Duan, Wanting Bai, Xinbo Wang, Baolian Wang, Yan Su, Jinping Hu. Inhibitory interaction of flavonoids with organic cation transporter 2 and their structure-activity relationships for predicting nephroprotective effects. Journal of applied toxicology : JAT. 2023 Apr; ?(?):. doi: 10.1002/jat.4474. [PMID: 37057715]
  • Li Hu, Zhiyun Liang, Yawen Wang, Gang Wei, Yue-Chun Huang. Identification of C-glycosyl flavones and O-glycosyl flavones in five Dendrobium species by high-performance liquid chromatography coupled with electrospray ionization multi-stage tandem MS. Rapid communications in mass spectrometry : RCM. 2022 Dec; 36(2):e9158. doi: 10.1002/rcm.9158. [PMID: 34223677]
  • Qing-Wen Wu, Min Wei, Ling-Fang Feng, Li Ding, Wu-Ke Wei, Jin-Fen Yang, Xiao-Jing Lin, Hui-Lin Liang, Ruo-Ting Zhan, Dong-Ming Ma. Rhamnosyltransferases involved in the biosynthesis of flavone rutinosides in Chrysanthemum species. Plant physiology. 2022 11; 190(4):2122-2136. doi: 10.1093/plphys/kiac371. [PMID: 35947689]
  • Nadja Kampschulte, Tim Berking, Ibrahim E Çelik, Stefan F Kirsch, Nils Helge Schebb. Inhibition of cytochrome P450 monooxygenase-catalyzed oxylipin formation by flavonoids: Evaluation of structure-activity relationship towards CYP4F2-selective inhibitors. European journal of medicinal chemistry. 2022 Aug; 238(?):114332. doi: 10.1016/j.ejmech.2022.114332. [PMID: 35576701]
  • Yanjun Song, Le Sun, Pei Ma, Lijia Xu, Peigen Xiao. Dihydromyricetin prevents obesity via regulating bile acid metabolism associated with the farnesoid X receptor in ob/ob mice. Food & function. 2022 Mar; 13(5):2491-2503. doi: 10.1039/d1fo03971g. [PMID: 35147634]
  • Ranran Gao, Qian Lou, Lijun Hao, Guihong Qi, Ya Tian, Xiangdong Pu, Chunnian He, Yu Wang, Wenjie Xu, Zhichao Xu, Jingyuan Song. Comparative genomics reveal the convergent evolution of CYP82D and CYP706X members related to flavone biosynthesis in Lamiaceae and Asteraceae. The Plant journal : for cell and molecular biology. 2022 03; 109(5):1305-1318. doi: 10.1111/tpj.15634. [PMID: 34907610]
  • Abdur Rauf, Sami Bawazeer, Jesús Herrera-Bravo, Muslim Raza, Humaira Naz, Somia Gul, Naveed Muhammad, Zainab M Almarhoon, Yahia N Mabkhot, Mohamed Fawzy Ramadan, William N Setzer, Sevgi Durna Daştan, Shafi Mahmud, Javad Sharifi-Rad. Potent In Vitro Phosphodiesterase 1 Inhibition of Flavone Isolated from Pistacia integerrima Galls. BioMed research international. 2022; 2022(?):6116003. doi: 10.1155/2022/6116003. [PMID: 35083331]
  • Xiaorong Sun, Xiaofeng Xue, Xiaqing Wang, Chun Zhang, Dengyu Zheng, Wei Song, Jiuran Zhao, Jianhua Wei, Zhongyi Wu, Zhongbao Zhang. Natural variation of ZmCGT1 is responsible for isoorientin accumulation in maize silk. The Plant journal : for cell and molecular biology. 2022 01; 109(1):64-76. doi: 10.1111/tpj.15549. [PMID: 34695260]
  • Antonella Rosa, Raffaella Isola, Federica Pollastro, Mariella Nieddu. Effect of the natural polymethoxylated flavone artemetin on lipid oxidation and its impact on cancer cell viability and lipids. Fitoterapia. 2022 Jan; 156(?):105102. doi: 10.1016/j.fitote.2021.105102. [PMID: 34921927]
  • Tao Chen, Xue Yang, Shuo Wang, Cheng Shen, Hongmei Li, Yangfei Wei, Shuping Yan, Zhibo Song, Fengmei Yang, Yarong Liu, Ping Hai, Yulin Li. Separation of five flavone glycosides including two groups with similar polarities from Dracocephalum tanguticum by a combination of three high-speed counter-current chromatography modes. Journal of separation science. 2022 Jan; 45(2):468-476. doi: 10.1002/jssc.202100537. [PMID: 34739178]
  • Ningnan Zhang, Shiyu Xue, Jie Song, Xiuren Zhou, Dahao Zhou, Xiaojin Liu, Zhou Hong, Daping Xu. Effects of various artificial agarwood-induction techniques on the metabolome of Aquilaria sinensis. BMC plant biology. 2021 Dec; 21(1):591. doi: 10.1186/s12870-021-03378-8. [PMID: 34903180]
  • Yonglu Li, Xin Yu, Lingchi Deng, Su Zhou, Yaxuan Wang, Xiaodong Zheng, Qiang Chu. Neochlorogenic acid anchors MCU-based calcium overload for cancer therapy. Food & function. 2021 Nov; 12(22):11387-11398. doi: 10.1039/d1fo01393a. [PMID: 34672304]
  • Yuxi Wang, Li-Jie Zhou, Yiguang Wang, Shenhui Liu, Zhiqiang Geng, Aiping Song, Jiafu Jiang, Sumei Chen, Fadi Chen. Functional identification of a flavone synthase and a flavonol synthase genes affecting flower color formation in Chrysanthemum morifolium. Plant physiology and biochemistry : PPB. 2021 Sep; 166(?):1109-1120. doi: 10.1016/j.plaphy.2021.07.019. [PMID: 34328869]
  • Ling Chen, Changliang Yao, Jiayuan Li, Jing Wang, Shuai Yao, Shijie Shen, Lin Yang, Jianqing Zhang, Wenlong Wei, Qirui Bi, De-An Guo. Systematic characterization of chemical constituents in Mahuang decoction by UHPLC tandem linear ion trap-Orbitrap mass spectrometry coupled with feature-based molecular networking. Journal of separation science. 2021 Jul; 44(14):2717-2727. doi: 10.1002/jssc.202100121. [PMID: 33963673]
  • Yuan Xiong, Guang-Hao Zhu, Hao-Nan Wang, Qing Hu, Li-Li Chen, Xiao-Qing Guan, Hui-Liang Li, Hong-Zhuan Chen, Hui Tang, Guang-Bo Ge. Discovery of naturally occurring inhibitors against SARS-CoV-2 3CLpro from Ginkgo biloba leaves via large-scale screening. Fitoterapia. 2021 Jul; 152(?):104909. doi: 10.1016/j.fitote.2021.104909. [PMID: 33894315]
  • Matthieu Bourdon, Josephine Gaynord, Karin H Müller, Gareth Evans, Simon Wallis, Paul Aston, David R Spring, Raymond Wightman. Microscopy and chemical analyses reveal flavone-based woolly fibres extrude from micron-sized holes in glandular trichomes of Dionysia tapetodes. BMC plant biology. 2021 Jun; 21(1):258. doi: 10.1186/s12870-021-03010-9. [PMID: 34134628]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Patchima Sithisarn, Piyanuch Rojsanga, Pongtip Sithisarn. Flavone-Rich Fractions and Extracts from Oroxylum indicum and Their Antibacterial Activities against Clinically Isolated Zoonotic Bacteria and Free Radical Scavenging Effects. Molecules (Basel, Switzerland). 2021 Mar; 26(6):. doi: 10.3390/molecules26061773. [PMID: 33809943]
  • Ankur Kumar Tanwar, Neha Dhiman, Amit Kumar, Vikas Jaitak. Engagement of phytoestrogens in breast cancer suppression: Structural classification and mechanistic approach. European journal of medicinal chemistry. 2021 Mar; 213(?):113037. doi: 10.1016/j.ejmech.2020.113037. [PMID: 33257172]
  • Duraisamy Kempuraj, Ramasamy Thangavel, Deepak D Kempuraj, Mohammad Ejaz Ahmed, Govindhasamy Pushpavathi Selvakumar, Sudhanshu P Raikwar, Smita A Zaheer, Shankar S Iyer, Raghav Govindarajan, Premkumar Nattanmai Chandrasekaran, Asgar Zaheer. Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma. BioFactors (Oxford, England). 2021 Mar; 47(2):190-197. doi: 10.1002/biof.1687. [PMID: 33098588]
  • Shabir Ahmad Ganai, Farooq Ahmad Sheikh, Zahoor Ahmad Baba. Plant flavone Chrysin as an emerging histone deacetylase inhibitor for prosperous epigenetic-based anticancer therapy. Phytotherapy research : PTR. 2021 Feb; 35(2):823-834. doi: 10.1002/ptr.6869. [PMID: 32930436]
  • Jun-Yan Xiang, Yan-Yu Chi, Jin-Xin Han, Hongyu Xiang, Qiuhong Xie. The Toxicity and Attenuation Methods of Toxic Chinese Materia Medica for its Reasonable Application: A Review. The American journal of Chinese medicine. 2021; 49(1):41-67. doi: 10.1142/s0192415x21500038. [PMID: 33416023]
  • Annelie Gutsch, Sophie Hendrix, Gea Guerriero, Jenny Renaut, Stanley Lutts, Saleh Alseekh, Alisdair R Fernie, Jean-Francois Hausman, Jaco Vangronsveld, Ann Cuypers, Kjell Sergeant. Long-Term Cd Exposure Alters the Metabolite Profile in Stem Tissue of Medicago sativa. Cells. 2020 12; 9(12):. doi: 10.3390/cells9122707. [PMID: 33348837]
  • Xin Huang, Junxiang Zhu, Li Wang, Huijuan Jing, Chaoyang Ma, Xingran Kou, Hongxin Wang. Inhibitory mechanisms and interaction of tangeretin, 5-demethyltangeretin, nobiletin, and 5-demethylnobiletin from citrus peels on pancreatic lipase: Kinetics, spectroscopies, and molecular dynamics simulation. International journal of biological macromolecules. 2020 Dec; 164(?):1927-1938. doi: 10.1016/j.ijbiomac.2020.07.305. [PMID: 32795575]
  • Mao Seoka, Gang Ma, Lancui Zhang, Masaki Yahata, Kazuki Yamawaki, Toshiyuki Kan, Masaya Kato. Expression and functional analysis of the nobiletin biosynthesis-related gene CitOMT in citrus fruit. Scientific reports. 2020 09; 10(1):15288. doi: 10.1038/s41598-020-72277-z. [PMID: 32943728]
  • Hayat Kherkhache, Imane Benabdelaziz, Artur M S Silva, Mokhtar Boualem Lahrech, Mokhtar Benalia, Hamada Haba. A new indole alkaloid, antioxidant and antibacterial activities of crude extracts from Saccocalyx satureioides. Natural product research. 2020 Jun; 34(11):1528-1534. doi: 10.1080/14786419.2018.1519817. [PMID: 30445859]
  • Chao Niu, Jia Sun, Yongquan Zheng, Linlin Wang, Jian Zhang, Ruijie Chen, Weijian Ye. Determination of isosinensetin in rat plasma by UHPLC-MS/MS: Application to oral and intravenous pharmacokinetic study in healthy rats. Journal of pharmaceutical and biomedical analysis. 2020 May; 184(?):113210. doi: 10.1016/j.jpba.2020.113210. [PMID: 32126459]
  • Weidong Dai, Zhengyan Hu, Dongchao Xie, Junfeng Tan, Zhi Lin. A novel spatial-resolution targeted metabolomics method in a single leaf of the tea plant (Camellia sinensis). Food chemistry. 2020 May; 311(?):126007. doi: 10.1016/j.foodchem.2019.126007. [PMID: 31855776]
  • Wenzhen Zhu, Yanping Zhu, Huan Xu, Ting Wang, Jing Wang, Min Meng, Ying Liu, Han Yan, Qiaozhi Yang, Peiman Liu. Flavone inhibited proliferation of T-ALL by promoting c-Cbl-induced ubiquitinylation and degradation of Notch1. Biochemical and biophysical research communications. 2020 02; 522(3):684-689. doi: 10.1016/j.bbrc.2019.11.148. [PMID: 31785807]
  • Ninh The Son, Midori Suenaga, Yoiichi Matsunaga, Luu Van Chinh, Miwa Kubo, Kenichi Harada, Nguyen Manh Cuong, Yoshiyasu Fukuyama. Serine protease inhibitors and activators from Dalbergia tonkinensis species. Journal of natural medicines. 2020 Jan; 74(1):257-263. doi: 10.1007/s11418-019-01347-y. [PMID: 31352545]
  • Liang Zhang. Pharmacokinetics and drug delivery systems for puerarin, a bioactive flavone from traditional Chinese medicine. Drug delivery. 2019 Dec; 26(1):860-869. doi: 10.1080/10717544.2019.1660732. [PMID: 31524010]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Magdalena Zuk, Jakub Szperlik, Agata Hnitecka, Jan Szopa. Temporal biosynthesis of flavone constituents in flax growth stages. Plant physiology and biochemistry : PPB. 2019 Sep; 142(?):234-245. doi: 10.1016/j.plaphy.2019.07.009. [PMID: 31323536]
  • Huijuan Zhang, Guifang Tian, Chengying Zhao, Yanhui Han, Christina DiMarco-Crook, Chang Lu, Yuming Bao, Chengxiu Li, Hang Xiao, Jinkai Zheng. Characterization of polymethoxyflavone demethylation during drying processes of citrus peels. Food & function. 2019 Sep; 10(9):5707-5717. doi: 10.1039/c9fo01053j. [PMID: 31436765]
  • Zhao Gao, Zi-Yuan Wang, Yong Guo, Chu Chu, Guo-Dong Zheng, E-Hu Liu, Fei Li. Enrichment of polymethoxyflavones from Citrus reticulata 'Chachi' peels and their hypolipidemic effect. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Aug; 1124(?):226-232. doi: 10.1016/j.jchromb.2019.06.010. [PMID: 31233943]
  • Ming-Tai Chen, Ruo-Lan Huang, Li-Jun Ou, Ying-Nan Chen, Ling Men, Xiao Chang, Ling Wang, Yu-Zhu Yang, Zhong Zhang. Pollen Typhae Total Flavone Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis in Human Aortic-Vascular Smooth Muscle Cells through Down-Regulating PERK-eIF2α-ATF4-CHOP Pathway. Chinese journal of integrative medicine. 2019 Aug; 25(8):604-612. doi: 10.1007/s11655-019-3052-4. [PMID: 30707413]
  • Michael McCullagh, Cintia Alessandra Matiucci Pereira, Janete Harumi Yariwake. Use of ion mobility mass spectrometry to enhance cumulative analytical specificity and separation to profile 6-C/8-C-glycosylflavone critical isomer pairs and known-unknowns in medicinal plants. Phytochemical analysis : PCA. 2019 Jul; 30(4):424-436. doi: 10.1002/pca.2825. [PMID: 30891865]
  • Pui Ying Lam, Andy C W Lui, Masaomi Yamamura, Lanxiang Wang, Yuri Takeda, Shiro Suzuki, Hongjia Liu, Fu-Yuan Zhu, Mo-Xian Chen, Jianhua Zhang, Toshiaki Umezawa, Yuki Tobimatsu, Clive Lo. Recruitment of specific flavonoid B-ring hydroxylases for two independent biosynthesis pathways of flavone-derived metabolites in grasses. The New phytologist. 2019 07; 223(1):204-219. doi: 10.1111/nph.15795. [PMID: 30883799]
  • Haruna Nagayoshi, Norie Murayama, Kensaku Kakimoto, Masaki Tsujino, Shigeo Takenaka, Jun Katahira, Young-Ran Lim, Donghak Kim, Hiroshi Yamazaki, Masayuki Komori, F Peter Guengerich, Tsutomu Shimada. Oxidation of Flavone, 5-Hydroxyflavone, and 5,7-Dihydroxyflavone to Mono-, Di-, and Tri-Hydroxyflavones by Human Cytochrome P450 Enzymes. Chemical research in toxicology. 2019 06; 32(6):1268-1280. doi: 10.1021/acs.chemrestox.9b00078. [PMID: 30964977]
  • Shiqi Zheng, Di Geng, Shuangyue Liu, Qingqing Wang, Siqi Liu, Rufeng Wang. A newly isolated human intestinal bacterium strain capable of deglycosylating flavone C-glycosides and its functional properties. Microbial cell factories. 2019 May; 18(1):94. doi: 10.1186/s12934-019-1144-7. [PMID: 31138294]
  • Adlin Afzan, Noraini Kasim, Nor Hadiani Ismail, Norfaizura Azmi, Abdul Manaf Ali, Nashriyah Mat, Jean-Luc Wolfender. Differentiation of Ficus deltoidea varieties and chemical marker determination by UHPLC-TOFMS metabolomics for establishing quality control criteria of this popular Malaysian medicinal herb. Metabolomics : Official journal of the Metabolomic Society. 2019 03; 15(3):35. doi: 10.1007/s11306-019-1489-2. [PMID: 30830457]
  • Shi Chen, Mohammed Esmail Abdalla Elzaki, Chaohui Ding, Zheng-Fang Li, Jie Wang, Ren-Sen Zeng, Yuan-Yuan Song. Plant allelochemicals affect tolerance of polyphagous lepidopteran pest Helicoverpa armigera (Hübner) against insecticides. Pesticide biochemistry and physiology. 2019 Feb; 154(?):32-38. doi: 10.1016/j.pestbp.2018.12.009. [PMID: 30765054]
  • Liangrui Zhong, Xiaohong Yang, Yiping Zhu, Jianzhong Peng, Yi Cao. Radix Tetrastigma Hemsleyani Flavone Suppresses Cutaneous Squamous Cell Carcinoma A431 Cells via Proteasome Inhibition. Medical science monitor : international medical journal of experimental and clinical research. 2019 Jan; 25(?):436-442. doi: 10.12659/msm.913889. [PMID: 30643111]
  • Sheng Wu, Li Tian. A new flavone glucoside together with known ellagitannins and flavones with anti-diabetic and anti-obesity activities from the flowers of pomegranate (Punica granatum). Natural product research. 2019 Jan; 33(2):252-257. doi: 10.1080/14786419.2018.1446009. [PMID: 29502447]
  • Jing Shi, Guofeng Wu, Xiaohua Zou, Ke Jiang. Enteral Baicalin, a Flavone Glycoside, Reduces Indicators of Cardiac Surgery-Associated Acute Kidney Injury in Rats. Cardiorenal medicine. 2019; 9(1):31-40. doi: 10.1159/000492159. [PMID: 30404080]
  • Jin-Pyo An, Lan Huong Dang, Thi Kim Quy Ha, Ha Thanh Tung Pham, Ba-Wool Lee, Chul Ho Lee, Won Keun Oh. Flavone glycosides from Sicyos angulatus and their inhibitory effects on hepatic lipid accumulation. Phytochemistry. 2019 Jan; 157(?):53-63. doi: 10.1016/j.phytochem.2018.10.013. [PMID: 30368219]
  • Thamsanqa Ngabaza, Sharon Moeno, Mrudula Patel. Anti-acidogenic and anti-biofilm activity of 5,6,8-trihydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one. Microbial pathogenesis. 2018 Oct; 123(?):149-152. doi: 10.1016/j.micpath.2018.07.003. [PMID: 30008421]
  • Hyun Lim, Dong Suk Min, Haeil Park, Hyun Pyo Kim. Flavonoids interfere with NLRP3 inflammasome activation. Toxicology and applied pharmacology. 2018 09; 355(?):93-102. doi: 10.1016/j.taap.2018.06.022. [PMID: 29960001]
  • Daisuke Nakabo, Yuka Okano, Naomi Kandori, Taisei Satahira, Naoya Kataoka, Junpei Akamatsu, Yoshiharu Okada. Convenient Synthesis and Physiological Activities of Flavonoids in Coreopsis lanceolata L. Petals and Their Related Compounds. Molecules (Basel, Switzerland). 2018 Jul; 23(7):. doi: 10.3390/molecules23071671. [PMID: 29987259]
  • Naima Rahmouni, Diana C G A Pinto, Noureddine Beghidja, Samir Benayache, Artur M S Silva. Scabiosa stellata L. Phenolic Content Clarifies Its Antioxidant Activity. Molecules (Basel, Switzerland). 2018 May; 23(6):. doi: 10.3390/molecules23061285. [PMID: 29861483]
  • Yousuf Sameena, Israel V M V Enoch. Interaction of a flavone loaded on surface-modified dextran-spooled superparamagnetic nanoparticles with β-cyclodextrin and DNA. Journal of biomolecular structure & dynamics. 2018 May; 36(7):1908-1917. doi: 10.1080/07391102.2017.1337592. [PMID: 28583036]
  • Dominic Brauch, Andrea Porzel, Erika Schumann, Klaus Pillen, Hans-Peter Mock. Changes in isovitexin-O-glycosylation during the development of young barley plants. Phytochemistry. 2018 Apr; 148(?):11-20. doi: 10.1016/j.phytochem.2018.01.001. [PMID: 29421507]
  • De-Jun Wang, Yue-Qin Cai, Shui-Zhen Pan, Li-Zong Zhang, Yun-Xiang Chen, Fang-Ming Chen, Ming Jin, Mao-Xiang Yan, Xiao-Dong Li, Zhi-Yun Chen. Effect of Total Flavone of Haw Leaves on Nuclear Factor Erythroid-2 Related Factor and Other Related Factors in Nonalcoholic Steatohepatitis Rats. Chinese journal of integrative medicine. 2018 Apr; 24(4):265-271. doi: 10.1007/s11655-016-2450-0. [PMID: 26919834]
  • Chen Yang, Zhengyan Hu, Meiling Lu, Pengliang Li, Junfeng Tan, Mei Chen, Haipeng Lv, Yin Zhu, Yue Zhang, Li Guo, Qunhua Peng, Weidong Dai, Zhi Lin. Application of metabolomics profiling in the analysis of metabolites and taste quality in different subtypes of white tea. Food research international (Ottawa, Ont.). 2018 04; 106(?):909-919. doi: 10.1016/j.foodres.2018.01.069. [PMID: 29580004]
  • Anil Shrestha, Ramesh Prasad Pandey, Dipesh Dhakal, Prakash Parajuli, Jae Kyung Sohng. Biosynthesis of flavone C-glucosides in engineered Escherichia coli. Applied microbiology and biotechnology. 2018 Feb; 102(3):1251-1267. doi: 10.1007/s00253-017-8694-6. [PMID: 29308528]
  • Claudia Vetrani, Marilena Vitale, Lutgarda Bozzetto, Giuseppe Della Pepa, Sara Cocozza, Giuseppina Costabile, Anna Mangione, Paola Cipriano, Giovanni Annuzzi, Angela A Rivellese. Association between different dietary polyphenol subclasses and the improvement in cardiometabolic risk factors: evidence from a randomized controlled clinical trial. Acta diabetologica. 2018 Feb; 55(2):149-153. doi: 10.1007/s00592-017-1075-x. [PMID: 29151225]
  • Fu-Lai Yu, Na Zhao, Zhi-Sheng Wu, Mei Huang, Dan Wang, Ying-Bo Zhang, Xuan Hu, Xiao-Lu Chen, Lu-Qi Huang, Yu-Xin Pang. NIR Rapid Assessments of Blumea balsamifera (Ai-na-xiang) in China. Molecules (Basel, Switzerland). 2017 Oct; 22(10):. doi: 10.3390/molecules22101730. [PMID: 29035305]
  • Yan-Ping Li, Qiu-Fen Hu, Gao-Xiong Rao. Three new C-alkylated flavonoids from Desmodium oblongum. Journal of Asian natural products research. 2017 Oct; 19(10):954-959. doi: 10.1080/10286020.2017.1285910. [PMID: 28145124]
  • Qing-Hua Huang, Chun Lei, Pei-Pei Wang, Jing-Ya Li, Jia Li, Ai-Jun Hou. Isoprenylated phenolic compounds with PTP1B inhibition from Morus alba. Fitoterapia. 2017 Oct; 122(?):138-143. doi: 10.1016/j.fitote.2017.09.006. [PMID: 28916258]
  • Elisabetta Corradi, Nadine Schmidt, Nathalie Räber, Maria De Mieri, Matthias Hamburger, Veronika Butterweck, Olivier Potterat. Metabolite Profile and Antiproliferative Effects in HaCaT Cells of a Salix reticulata Extract. Planta medica. 2017 Oct; 83(14-15):1149-1158. doi: 10.1055/s-0043-109098. [PMID: 28449181]
  • Sreeparna Das, Shaikh Batuta, Md Niharul Alam, Chandrani Fouzder, Rakesh Kundu, Debabrata Mandal, Naznin Ara Begum. Antioxidant flavone analog functionalized fluorescent silica nanoparticles: Synthesis and exploration of their possible use as biomolecule sensor. Colloids and surfaces. B, Biointerfaces. 2017 Sep; 157(?):286-296. doi: 10.1016/j.colsurfb.2017.05.074. [PMID: 28601757]
  • Xiao-Tao Feng, Hui-Ming Duan, Shuang-Lei Li. Protective role of Pollen Typhae total flavone against the palmitic acid-induced impairment of glucose-stimulated insulin secretion involving GPR40 signaling in INS-1 cells. International journal of molecular medicine. 2017 Sep; 40(3):922-930. doi: 10.3892/ijmm.2017.3070. [PMID: 28731171]
  • Yoshiki Miyata, Terumasa Nagase, Yoshiya Katsura, Hideyo Takahashi, Hideaki Natsugari, Tetsuta Oshitari, Hiroshi Kosano. In vitro studies on nobiletin isolated from citrus plants and the bioactive metabolites, inhibitory action against gelatinase enzymatic activity and the molecular mechanisms in human retinal Müller cell line. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Sep; 93(?):70-80. doi: 10.1016/j.biopha.2017.06.017. [PMID: 28623785]
  • Jelena Č Živković, João C M Barreira, Katarina P Šavikin, Ana Z Alimpić, Dejan S Stojković, Maria Inês Dias, Celestino Santos-Buelga, Sonja N Duletić-Laušević, Isabel C F R Ferreira. Chemical Profiling and Assessment of Antineurodegenerative and Antioxidant Properties of Veronica teucrium L. and Veronica jacquinii Baumg. Chemistry & biodiversity. 2017 Aug; 14(8):. doi: 10.1002/cbdv.201700167. [PMID: 28488389]
  • Sohyun Kim, Gwang-Woong Go, Jee-Young Imm. Promotion of Glucose Uptake in C2C12 Myotubes by Cereal Flavone Tricin and Its Underlying Molecular Mechanism. Journal of agricultural and food chemistry. 2017 May; 65(19):3819-3826. doi: 10.1021/acs.jafc.7b00578. [PMID: 28474889]
  • Shizhe Li, Shu Liu, Zifeng Pi, Fengrui Song, Yongri Jin, Zhiqiang Liu. Chemical profiling of Fufang-Xialian-Capsule by UHPLC-Q-TOF-MS and its antioxidant activity evaluated by in vitro method. Journal of pharmaceutical and biomedical analysis. 2017 May; 138(?):289-301. doi: 10.1016/j.jpba.2017.01.060. [PMID: 28235732]
  • Yanli Qu, Shuai Liu, Wenlong Bao, Xian Xue, Zhengwen Ma, Ken Yokawa, František Baluška, Yinglang Wan. Expression of Root Genes in Arabidopsis Seedlings Grown by Standard and Improved Growing Methods. International journal of molecular sciences. 2017 May; 18(5):. doi: 10.3390/ijms18050951. [PMID: 28467358]
  • Tianshan Zhou, Youben Yu, Bin Xiao, Lu Bao, Yuefang Gao. [Engineering of a flavonoid 3'-hydroxylase from tea plant (Camellia sinensis) for biosynthesis of B-3',4'-dihydroxylated flavones]. Wei sheng wu xue bao = Acta microbiologica Sinica. 2017 Mar; 57(3):447-58. doi: . [PMID: 29756698]
  • Ying Yang, Chengying Zhao, Jingjing Chen, Guifang Tian, David Julian McClements, Hang Xiao, Jinkai Zheng. Encapsulation of Polymethoxyflavones in Citrus Oil Emulsion-Based Delivery Systems. Journal of agricultural and food chemistry. 2017 Mar; 65(8):1732-1739. doi: 10.1021/acs.jafc.7b00147. [PMID: 28182421]
  • Yelin Kang, Bong-Gyu Kim, Sunghoon Kim, Youngshim Lee, Youngdae Yoon. Inhibitory potential of flavonoids on PtdIns(3,4,5)P3 binding with the phosphoinositide-dependent kinase 1 pleckstrin homology domain. Bioorganic & medicinal chemistry letters. 2017 02; 27(3):420-426. doi: 10.1016/j.bmcl.2016.12.051. [PMID: 28049590]
  • Eutrophe Le Doux Kamto, Tatiane S C Carvalho, Joséphine Ngo Mbing, Marie C N Matene, Dieudonné E Pegnyemb, Gilda G Leitão. Alternating isocratic and step gradient elution high-speed counter-current chromatography for the isolation of minor phenolics from Ormocarpum kirkii bark. Journal of chromatography. A. 2017 Jan; 1480(?):50-61. doi: 10.1016/j.chroma.2016.12.026. [PMID: 27988077]
  • Jia-xin Fan, Shuai Wang, Xian-sheng Meng, Yong-rui Bao, Tian-jiao Li. [Study of cancer cell apoptosis induced by Schizonepeta tenuifolia with microfluidic chip technology]. Yao xue xue bao = Acta pharmaceutica Sinica. 2017 01; 52(1):126-31. doi: . [PMID: 29911809]
  • Fuad Al-Rimawi, Saleh Abu-Lafi, Jehad Abbadi, Ayman A A Alamarneh, Raneen A Sawahreh, Imad Odeh. ANALYSIS OF PHENOLIC AND FLAVONOIDS OF WILD EPHEDRA ALATA PLANT EXTRACTS BY LC/PDA AND LC/MS AND THEIR ANTIOXIDANT ACTIVITY. African journal of traditional, complementary, and alternative medicines : AJTCAM. 2017; 14(2):130-141. doi: 10.21010/ajtcam.v14i2.14. [PMID: 28573229]
  • Xiaofeng Yan, Tingjie Ye, Xudong Hu, Pei Zhao, Xiaoling Wang. 58-F, a flavanone from Ophiopogon japonicus, prevents hepatocyte death by decreasing lysosomal membrane permeability. Scientific reports. 2016 06; 6(?):27875. doi: 10.1038/srep27875. [PMID: 27306715]
  • Wu Lan, Kris Morreel, Fachuang Lu, Jorge Rencoret, José Carlos Del Río, Wannes Voorend, Wilfred Vermerris, Wout Boerjan, John Ralph. Maize Tricin-Oligolignol Metabolites and Their Implications for Monocot Lignification. Plant physiology. 2016 06; 171(2):810-20. doi: 10.1104/pp.16.02012. [PMID: 27208246]
  • Eshvendar Reddy Kasala, Lakshmi Narendra Bodduluru, Chandan C Barua, Rajaram Mohanrao Madhana, Vicky Dahiya, Mukesh Kumar Budhani, Ramana Reddy Mallugari, Suseela Reddy Maramreddy, Ranadeep Gogoi. Chemopreventive effect of chrysin, a dietary flavone against benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice. Pharmacological reports : PR. 2016 Apr; 68(2):310-8. doi: 10.1016/j.pharep.2015.08.014. [PMID: 26922533]
  • Qing Zhao, Yang Zhang, Gang Wang, Lionel Hill, Jing-Ke Weng, Xiao-Ya Chen, Hongwei Xue, Cathie Martin. A specialized flavone biosynthetic pathway has evolved in the medicinal plant, Scutellaria baicalensis. Science advances. 2016 Apr; 2(4):e1501780. doi: 10.1126/sciadv.1501780. [PMID: 27152350]
  • Chun Yang, Jun-Song Wang, Ling-Yi Kong. [A new biflavone from needles of Taxus canadensis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2016 Feb; 41(3):443-445. doi: 10.4268/cjcmm20160314. [PMID: 28868861]
  • Bing Hao, John C Caulfield, Mary L Hamilton, John A Pickett, Charles A O Midega, Zeyaur R Khan, Junru R Wang, Antony M Hooper. The biosynthesis of allelopathic di-C-glycosylflavones from the roots of Desmodium incanum (G. Mey.) DC. Organic & biomolecular chemistry. 2015 Dec; 13(48):11663-73. doi: 10.1039/c5ob01926e. [PMID: 26478440]
  • Kamalakannan Pandurangan, Vidyalakshmi Krishnappan, Viswanathan Subramanian, Ramaswamy Subramanyan. Anti-inflammatory effect of certain dimethoxy flavones. Inflammopharmacology. 2015 Dec; 23(6):307-17. doi: 10.1007/s10787-015-0242-3. [PMID: 26248971]
  • Li-mei Li, Jun Zhou, Jie Lou, Yue-de Wang, Kun Zhou, Wei Dong, Xue-mei Gao, Qiu-fen Hu, Zhi-yong Jiang. [A new flavone from stems of Garcinia bracteata and its anti-TMV activity]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2015 Nov; 40(21):4205-7. doi: ". [PMID: 27071257]
  • Fan Zhang, Ya-Nan Yang, Xiu-Yun Song, Si-Yuan Shao, Zi-Ming Feng, Jian-Shuang Jiang, Li Li, Nai-Hong Chen, Pei-Cheng Zhang. Forsythoneosides A-D, Neuroprotective Phenethanoid and Flavone Glycoside Heterodimers from the Fruits of Forsythia suspensa. Journal of natural products. 2015 Oct; 78(10):2390-7. doi: 10.1021/acs.jnatprod.5b00372. [PMID: 26422318]
  • Mengliang Zhang, Jianghao Sun, Pei Chen. FlavonQ: an automated data processing tool for profiling flavone and flavonol glycosides with ultra-high-performance liquid chromatography-diode array detection-high resolution accurate mass-mass spectrometry. Analytical chemistry. 2015 Oct; 87(19):9974-81. doi: 10.1021/acs.analchem.5b02624. [PMID: 26359695]
  • Jackson R G S Almeida, Juliane C Silva, Amanda L Guimarães, Ana P Oliveira, Grasielly R Souza, Raimundo G Oliveira-Júnior, Sarah R G Lima-Saraiva, José M Barbosa-Filho, Raimundo Braz-Filho, Dinalva Brito Queiroz, Marco Antônio Botelho. 3,6-Dimethoxy-6″,6″-Dimethyl-(7,8,2″,3″)-Chromeneflavone, a Flavonoid Isolated from Lonchocarpus Araripensis Benth. (Fabaceae), Reduces Nociceptive Behaviour in Mice. Phytotherapy research : PTR. 2015 Oct; 29(10):1622-7. doi: 10.1002/ptr.5418. [PMID: 26172339]
  • Junhui Yan, Biao Wang, Yunpeng Zhong, Luming Yao, Linjing Cheng, Tianlong Wu. The soybean R2R3 MYB transcription factor GmMYB100 negatively regulates plant flavonoid biosynthesis. Plant molecular biology. 2015 Sep; 89(1-2):35-48. doi: 10.1007/s11103-015-0349-3. [PMID: 26231207]
  • Ananth Kumar Kammalla, Mohan Kumar Ramasamy, Jyothi Chintala, Govind Prasad Dubey, Aruna Agrawal, Ilango Kaliappan. Comparative pharmacokinetic interactions of Quercetin and Rutin in rats after oral administration of European patented formulation containing Hipphophae rhamnoides and Co-administration of Quercetin and Rutin. European journal of drug metabolism and pharmacokinetics. 2015 Sep; 40(3):277-84. doi: 10.1007/s13318-014-0206-9. [PMID: 24888486]
  • Xiaoqin Yao, Jian-Zhou Chu, Chun-Hui Ma, Chao Si, Ji-Gang Li, Xiao-Fei Shi, Chao-Nan Liu. Biochemical traits and proteomic changes in postharvest flowers of medicinal chrysanthemum exposed to enhanced UV-B radiation. Journal of photochemistry and photobiology. B, Biology. 2015 Aug; 149(?):272-9. doi: 10.1016/j.jphotobiol.2015.06.017. [PMID: 26114222]
  • Bin Liu, Yi Pang, Rachida Bouhenni, Ernest Duah, Sailaja Paruchuri, Lucas McDonald. A step toward simplified detection of serum albumin on SDS-PAGE using an environment-sensitive flavone sensor. Chemical communications (Cambridge, England). 2015 Jul; 51(55):11060-3. doi: 10.1039/c5cc03516c. [PMID: 26068596]
  • Yin-Ning Chen, Yan Peng, Cheng-Hai Gao, Tao Yan, Zhi-Fang Xu, Samuel X Qius, Wen-Hao Cao, Ligao Deng, Ri-Ming Huang. Two New Secondary Metabolites from Tephrosia purpurea. Natural product communications. 2015 Jun; 10(6):921-2. doi: ". [PMID: 26197516]
  • Qiang Li, Liping Wang, Peimin Dai, Xuejun Zeng, Xiaoxiao Qi, Lijun Zhu, Tongmeng Yan, Ying Wang, Linlin Lu, Ming Hu, Xinchun Wang, Zhongqiu Liu. A combined strategy of mass fragmentation, post-column cobalt complexation and shift in ultraviolet absorption spectra to determine the uridine 5'-diphospho-glucuronosyltransferase metabolism profiling of flavones after oral administration of a flavone mixture in rats. Journal of chromatography. A. 2015 May; 1395(?):116-28. doi: 10.1016/j.chroma.2015.03.069. [PMID: 25892633]
  • Yearam Jung, Soon Young Shin, Yeonjoong Yong, Hyeryoung Jung, Seunghyun Ahn, Young Han Lee, Yoongho Lim. Plant-derived flavones as inhibitors of aurora B kinase and their quantitative structure-activity relationships. Chemical biology & drug design. 2015 May; 85(5):574-85. doi: 10.1111/cbdd.12445. [PMID: 25298094]
  • Rui-Long Wang, Qing-Qing Xia, Scott R Baerson, Yong Ren, Jie Wang, Yi-Juan Su, Si-Chun Zheng, Ren-Sen Zeng. A novel cytochrome P450 CYP6AB14 gene in Spodoptera litura (Lepidoptera: Noctuidae) and its potential role in plant allelochemical detoxification. Journal of insect physiology. 2015 Apr; 75(?):54-62. doi: 10.1016/j.jinsphys.2015.02.013. [PMID: 25783953]
  • Zuyi Weng, Arti B Patel, Smaro Panagiotidou, Theoharis C Theoharides. The novel flavone tetramethoxyluteolin is a potent inhibitor of human mast cells. The Journal of allergy and clinical immunology. 2015 Apr; 135(4):1044-1052.e5. doi: 10.1016/j.jaci.2014.10.032. [PMID: 25498791]
  • Jihong Hu, Xiaojun Chen, Hongyuan Zhang, Yi Ding. Genome-wide analysis of DNA methylation in photoperiod- and thermo-sensitive male sterile rice Peiai 64S. BMC genomics. 2015 Feb; 16(?):102. doi: 10.1186/s12864-015-1317-7. [PMID: 25887533]
  • Zong-Ping Zheng, Xue Dong, Kun Yuan, Shan Lan, Qin Zhu, Mingfu Wang, Jie Chen. Preparation, characterization, and preliminary antibrowning evaluations of norartocarpetin microemulsions. Journal of agricultural and food chemistry. 2015 Feb; 63(5):1615-21. doi: 10.1021/jf5048805. [PMID: 25603116]
  • Huixiao Hong, William S Branham, Hui Wen Ng, Carrie L Moland, Stacey L Dial, Hong Fang, Roger Perkins, Daniel Sheehan, Weida Tong. Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein. Toxicological sciences : an official journal of the Society of Toxicology. 2015 Feb; 143(2):333-48. doi: 10.1093/toxsci/kfu231. [PMID: 25349334]
  • Yuwen Ting, Colin C Li, Yin Wang, Chi-Tang Ho, Qingrong Huang. Influence of processing parameters on morphology of polymethoxyflavone in emulsions. Journal of agricultural and food chemistry. 2015 Jan; 63(2):652-9. doi: 10.1021/jf504465a. [PMID: 25537008]