Flavone (BioDeep_00001867465)

Main id: BioDeep_00000000109

Secondary id: BioDeep_00000014478, BioDeep_00000270224, BioDeep_00000868303

human metabolite PANOMIX_OTCML-2023 natural product


代谢物信息卡片


InChI=1/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10

化学式: C15H10O2 (222.0681)
中文名称: 黄酮
谱图信息: 最多检出来源 Homo sapiens(blood) 37.27%

分子结构信息

SMILES: C1=CC2OC(C3C=CC=CC=3)=CC(=O)C=2C=C1
InChI: InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H

描述信息

Flavone is the simplest member of the class of flavones that consists of 4H-chromen-4-one bearing a phenyl substituent at position 2. It has a role as a metabolite and a nematicide.
Flavone is a natural product found in Grindelia hirsutula, Asphodeline damascena, and other organisms with data available.
Quercetin is a flavonoid that forms the "backbone" for many other flavonoids, including the citrus flavonoids rutin, hesperidin, naringin and tangeritin. In studies, quercetin is found to be the most active of the flavonoids, and many medicinal plants owe much of their activity to their high quercetin content. Quercetin has demonstrated significant anti-inflammatory activity because of direct inhibition of several initial processes of inflammation. For example, it inhibits both the manufacture and release of histamine and other allergic/inflammatory mediators. In addition, it exerts potent antioxidant activity and vitamin C-sparing action.
Quercetin is a flavonoid that forms the "backbone" for many other flavonoids, including the citrus flavonoids rutin, hesperidin, naringin and tangeritin. In studies, quercetin is found to be the most active of the flavonoids, and many medicinal plants owe much of their activity to their high quercetin content. Quercetin has demonstrated significant anti-inflammatory activity because of direct inhibition of several initial processes of inflammation. For example, it inhibits both the manufacture and release of histamine and other allergic/inflammatory mediators. In addition, it exerts potent antioxidant activity and vitamin C-sparing action. -- Wikipedia.
Flavones (flavus = yellow), are a class of flavonoids based on the backbone of 2-phenylchromen-4-one (2-phenyl-1-benzopyran-4-one). Flavones is found in many foods, some of which are dill, feijoa, pomegranate, and rosemary.
The simplest member of the class of flavones that consists of 4H-chromen-4-one bearing a phenyl substituent at position 2.
Flavone is an endogenous metabolite.
Flavone is an endogenous metabolite.

同义名列表

47 个代谢物同义名

InChI=1/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10; 5-17-10-00552 (Beilstein Handbook Reference); 6CC153EB-39A6-42FC-BE96-C8BF1D585E27; 4H-1-Benzopyran-4-one, 2-phenyl-; 2-Phenyl-4H-1-benzopyran-4-one; 2-Phenyl-.gamma.-benzopyrone; 2-Phenyl-4H-benzopyran-4-one; 2-Phenylbenzo[b]pyran-4-one; 2-phenyl-1-benzopyran-4-one; 2-Phenyl-4H-chromen-4-one #; 2-Phenyl-gamma-benzopyrone; 2-Phenyl-4H-chromen-4-one; 2-Phenyl-4H-chromen-4-on; 2-Phenylbenzopyran-4-one; 2-phenyl-1,4-benzopyrone; 2-Phenyl-γ-benzopyrone; 2-Phenyl-g-benzopyrone; 2-Phenyl-chromen-4-one; 2-Phenyl-4-benzopyron; 2-phenylchromen-4-one; 2-phenyl-4H-chromone; flavone, 14C-labeled; 2-Phenyl-4-chromone; Maybridge3_005286; 2-Phenylchromone; Flavone, Flavone; UNII-S2V45N7G3B; Phenylchromone; MEGxp0_001685; Flavone (VAN); FLAVONE [MI]; ICCB2_000263; ACon1_000055; Tox21_202987; Tox21_400059; IDI1_016673; S2V45N7G3B; Cromarile; Chromocor; Asmacoril; Cromaril; Flavones; Flavone; Flavon; 4hki; FLN; Flavone



数据库引用编号

28 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

60 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 15 ABCB1, AHR, ANXA5, BCL2, CASP3, CASP8, CASP9, CAT, CYP1A1, HPGDS, MAPK14, PIK3C3, PIK3CA, PTGS2, VEGFA
Peripheral membrane protein 4 ACHE, ANXA5, CYP1A1, PTGS2
Endoplasmic reticulum membrane 3 BCL2, CYP1A1, PTGS2
Cytoplasmic vesicle, autophagosome 1 PIK3C3
Nucleus 9 ACHE, AHR, BCL2, CASP3, CASP8, CASP9, MAPK14, PARP1, VEGFA
autophagosome 1 PIK3C3
cytosol 12 AHR, ANXA5, BCL2, CASP3, CASP8, CASP9, CAT, HPGDS, MAPK14, PARP1, PIK3C3, PIK3CA
nuclear body 1 PARP1
phosphatidylinositol 3-kinase complex, class III 1 PIK3C3
nucleoplasm 6 AHR, CASP3, CASP8, HPGDS, MAPK14, PARP1
Cell membrane 2 ABCB1, ACHE
lamellipodium 2 CASP8, PIK3CA
Multi-pass membrane protein 1 ABCB1
Synapse 1 ACHE
cell surface 3 ABCB1, ACHE, VEGFA
glutamatergic synapse 3 CASP3, MAPK14, PIK3C3
Golgi apparatus 2 ACHE, VEGFA
Golgi membrane 1 INS
lysosomal membrane 1 GAA
mitochondrial inner membrane 1 CYP1A1
neuromuscular junction 1 ACHE
neuronal cell body 1 CASP3
sarcolemma 1 ANXA5
Cytoplasm, cytosol 1 PARP1
Lysosome 1 GAA
endosome 1 PIK3C3
plasma membrane 4 ABCB1, ACHE, GAA, PIK3CA
Membrane 9 ABCB1, ACHE, ANXA5, BCL2, CAT, GAA, PARP1, PIK3C3, VEGFA
apical plasma membrane 1 ABCB1
caveola 1 PTGS2
extracellular exosome 4 ABCB1, ANXA5, CAT, GAA
Lysosome membrane 1 GAA
endoplasmic reticulum 3 BCL2, PTGS2, VEGFA
extracellular space 4 ACHE, IL6, INS, VEGFA
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 2 ACHE, PIK3CA
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 7 BCL2, CASP8, CASP9, CAT, CYP1A1, MAPK14, PARP1
protein-containing complex 7 AHR, BCL2, CASP8, CASP9, CAT, PARP1, PTGS2
intracellular membrane-bounded organelle 4 CAT, CYP1A1, GAA, HPGDS
Microsome membrane 2 CYP1A1, PTGS2
postsynaptic density 1 CASP3
Secreted 5 ACHE, GAA, IL6, INS, VEGFA
extracellular region 8 ACHE, ANXA5, CAT, GAA, IL6, INS, MAPK14, VEGFA
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, CASP8
mitochondrial matrix 1 CAT
Extracellular side 1 ACHE
transcription regulator complex 2 AHR, PARP1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 ANXA5
Secreted, extracellular space, extracellular matrix 1 VEGFA
nucleolus 1 PARP1
midbody 1 PIK3C3
Apical cell membrane 1 ABCB1
Cell projection, lamellipodium 1 CASP8
Mitochondrion inner membrane 1 CYP1A1
pore complex 1 BCL2
focal adhesion 2 ANXA5, CAT
GABA-ergic synapse 1 PIK3C3
extracellular matrix 1 VEGFA
Peroxisome 2 CAT, PIK3C3
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 ANXA5
secretory granule 1 VEGFA
axoneme 1 PIK3C3
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Late endosome 1 PIK3C3
Zymogen granule membrane 1 ANXA5
neuron projection 1 PTGS2
chromatin 2 AHR, PARP1
phagocytic vesicle membrane 1 PIK3C3
Chromosome 1 PARP1
cytoskeleton 1 CASP8
Nucleus, nucleolus 1 PARP1
spindle pole 1 MAPK14
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
Lipid-anchor, GPI-anchor 1 ACHE
site of double-strand break 1 PARP1
nuclear envelope 1 PARP1
endosome lumen 1 INS
phagophore assembly site 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type I 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type II 1 PIK3C3
aryl hydrocarbon receptor complex 1 AHR
tertiary granule membrane 1 GAA
cell body 1 CASP8
side of membrane 1 ACHE
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 3 CAT, INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 IL6, INS, PTGS2
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
azurophil granule membrane 1 GAA
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
presynaptic endosome 1 PIK3C3
apoptosome 1 CASP9
vesicle membrane 1 ANXA5
synaptic cleft 1 ACHE
protein-DNA complex 1 PARP1
ficolin-1-rich granule membrane 1 GAA
external side of apical plasma membrane 1 ABCB1
CD95 death-inducing signaling complex 1 CASP8
death-inducing signaling complex 2 CASP3, CASP8
ripoptosome 1 CASP8
site of DNA damage 1 PARP1
postsynaptic endosome 1 PIK3C3
Autolysosome 1 PIK3C3
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
endothelial microparticle 1 ANXA5
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
autolysosome lumen 1 GAA
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Isoform H]: Cell membrane 1 ACHE
nuclear aryl hydrocarbon receptor complex 1 AHR
cytosolic aryl hydrocarbon receptor complex 1 AHR
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
caspase complex 1 CASP9


文献列表

  • Kazutaka Murayama, Miyuki Kato-Murayama, Toshiaki Hosaka, Naoko Okitsu, Yoshikazu Tanaka, Mikako Shirouzu. Molecular basis of ligand recognition specificity of flavone glucosyltransferases in Nemophila menziesii. Archives of biochemistry and biophysics. 2024 Mar; 753(?):109926. doi: 10.1016/j.abb.2024.109926. [PMID: 38346547]
  • Ting Xu, Yangjun Lv, Yuhan Cui, Dongchen Liu, Tao Xu, Baiyi Lu, Xuan Yang. Properties of Dietary Flavone Glycosides, Aglycones, and Metabolites on the Catalysis of Human Endoplasmic Reticulum Uridine Diphosphate Glucuronosyltransferase 2B7 (UGT2B7). Nutrients. 2023 Nov; 15(23):. doi: 10.3390/nu15234941. [PMID: 38068799]
  • Huixin Tan, Fenghe Wang, Jiahuan Hu, Xiaoyan Duan, Wanting Bai, Xinbo Wang, Baolian Wang, Yan Su, Jinping Hu. Inhibitory interaction of flavonoids with organic cation transporter 2 and their structure-activity relationships for predicting nephroprotective effects. Journal of applied toxicology : JAT. 2023 Apr; ?(?):. doi: 10.1002/jat.4474. [PMID: 37057715]
  • Li Hu, Zhiyun Liang, Yawen Wang, Gang Wei, Yue-Chun Huang. Identification of C-glycosyl flavones and O-glycosyl flavones in five Dendrobium species by high-performance liquid chromatography coupled with electrospray ionization multi-stage tandem MS. Rapid communications in mass spectrometry : RCM. 2022 Dec; 36(2):e9158. doi: 10.1002/rcm.9158. [PMID: 34223677]
  • Qing-Wen Wu, Min Wei, Ling-Fang Feng, Li Ding, Wu-Ke Wei, Jin-Fen Yang, Xiao-Jing Lin, Hui-Lin Liang, Ruo-Ting Zhan, Dong-Ming Ma. Rhamnosyltransferases involved in the biosynthesis of flavone rutinosides in Chrysanthemum species. Plant physiology. 2022 11; 190(4):2122-2136. doi: 10.1093/plphys/kiac371. [PMID: 35947689]
  • Nadja Kampschulte, Tim Berking, Ibrahim E Çelik, Stefan F Kirsch, Nils Helge Schebb. Inhibition of cytochrome P450 monooxygenase-catalyzed oxylipin formation by flavonoids: Evaluation of structure-activity relationship towards CYP4F2-selective inhibitors. European journal of medicinal chemistry. 2022 Aug; 238(?):114332. doi: 10.1016/j.ejmech.2022.114332. [PMID: 35576701]
  • Yanjun Song, Le Sun, Pei Ma, Lijia Xu, Peigen Xiao. Dihydromyricetin prevents obesity via regulating bile acid metabolism associated with the farnesoid X receptor in ob/ob mice. Food & function. 2022 Mar; 13(5):2491-2503. doi: 10.1039/d1fo03971g. [PMID: 35147634]
  • Ranran Gao, Qian Lou, Lijun Hao, Guihong Qi, Ya Tian, Xiangdong Pu, Chunnian He, Yu Wang, Wenjie Xu, Zhichao Xu, Jingyuan Song. Comparative genomics reveal the convergent evolution of CYP82D and CYP706X members related to flavone biosynthesis in Lamiaceae and Asteraceae. The Plant journal : for cell and molecular biology. 2022 03; 109(5):1305-1318. doi: 10.1111/tpj.15634. [PMID: 34907610]
  • Abdur Rauf, Sami Bawazeer, Jesús Herrera-Bravo, Muslim Raza, Humaira Naz, Somia Gul, Naveed Muhammad, Zainab M Almarhoon, Yahia N Mabkhot, Mohamed Fawzy Ramadan, William N Setzer, Sevgi Durna Daştan, Shafi Mahmud, Javad Sharifi-Rad. Potent In Vitro Phosphodiesterase 1 Inhibition of Flavone Isolated from Pistacia integerrima Galls. BioMed research international. 2022; 2022(?):6116003. doi: 10.1155/2022/6116003. [PMID: 35083331]
  • Xiaorong Sun, Xiaofeng Xue, Xiaqing Wang, Chun Zhang, Dengyu Zheng, Wei Song, Jiuran Zhao, Jianhua Wei, Zhongyi Wu, Zhongbao Zhang. Natural variation of ZmCGT1 is responsible for isoorientin accumulation in maize silk. The Plant journal : for cell and molecular biology. 2022 01; 109(1):64-76. doi: 10.1111/tpj.15549. [PMID: 34695260]
  • Antonella Rosa, Raffaella Isola, Federica Pollastro, Mariella Nieddu. Effect of the natural polymethoxylated flavone artemetin on lipid oxidation and its impact on cancer cell viability and lipids. Fitoterapia. 2022 Jan; 156(?):105102. doi: 10.1016/j.fitote.2021.105102. [PMID: 34921927]
  • Tao Chen, Xue Yang, Shuo Wang, Cheng Shen, Hongmei Li, Yangfei Wei, Shuping Yan, Zhibo Song, Fengmei Yang, Yarong Liu, Ping Hai, Yulin Li. Separation of five flavone glycosides including two groups with similar polarities from Dracocephalum tanguticum by a combination of three high-speed counter-current chromatography modes. Journal of separation science. 2022 Jan; 45(2):468-476. doi: 10.1002/jssc.202100537. [PMID: 34739178]
  • Ningnan Zhang, Shiyu Xue, Jie Song, Xiuren Zhou, Dahao Zhou, Xiaojin Liu, Zhou Hong, Daping Xu. Effects of various artificial agarwood-induction techniques on the metabolome of Aquilaria sinensis. BMC plant biology. 2021 Dec; 21(1):591. doi: 10.1186/s12870-021-03378-8. [PMID: 34903180]
  • Yonglu Li, Xin Yu, Lingchi Deng, Su Zhou, Yaxuan Wang, Xiaodong Zheng, Qiang Chu. Neochlorogenic acid anchors MCU-based calcium overload for cancer therapy. Food & function. 2021 Nov; 12(22):11387-11398. doi: 10.1039/d1fo01393a. [PMID: 34672304]
  • Yuxi Wang, Li-Jie Zhou, Yiguang Wang, Shenhui Liu, Zhiqiang Geng, Aiping Song, Jiafu Jiang, Sumei Chen, Fadi Chen. Functional identification of a flavone synthase and a flavonol synthase genes affecting flower color formation in Chrysanthemum morifolium. Plant physiology and biochemistry : PPB. 2021 Sep; 166(?):1109-1120. doi: 10.1016/j.plaphy.2021.07.019. [PMID: 34328869]
  • Ling Chen, Changliang Yao, Jiayuan Li, Jing Wang, Shuai Yao, Shijie Shen, Lin Yang, Jianqing Zhang, Wenlong Wei, Qirui Bi, De-An Guo. Systematic characterization of chemical constituents in Mahuang decoction by UHPLC tandem linear ion trap-Orbitrap mass spectrometry coupled with feature-based molecular networking. Journal of separation science. 2021 Jul; 44(14):2717-2727. doi: 10.1002/jssc.202100121. [PMID: 33963673]
  • Yuan Xiong, Guang-Hao Zhu, Hao-Nan Wang, Qing Hu, Li-Li Chen, Xiao-Qing Guan, Hui-Liang Li, Hong-Zhuan Chen, Hui Tang, Guang-Bo Ge. Discovery of naturally occurring inhibitors against SARS-CoV-2 3CLpro from Ginkgo biloba leaves via large-scale screening. Fitoterapia. 2021 Jul; 152(?):104909. doi: 10.1016/j.fitote.2021.104909. [PMID: 33894315]
  • Matthieu Bourdon, Josephine Gaynord, Karin H Müller, Gareth Evans, Simon Wallis, Paul Aston, David R Spring, Raymond Wightman. Microscopy and chemical analyses reveal flavone-based woolly fibres extrude from micron-sized holes in glandular trichomes of Dionysia tapetodes. BMC plant biology. 2021 Jun; 21(1):258. doi: 10.1186/s12870-021-03010-9. [PMID: 34134628]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Patchima Sithisarn, Piyanuch Rojsanga, Pongtip Sithisarn. Flavone-Rich Fractions and Extracts from Oroxylum indicum and Their Antibacterial Activities against Clinically Isolated Zoonotic Bacteria and Free Radical Scavenging Effects. Molecules (Basel, Switzerland). 2021 Mar; 26(6):. doi: 10.3390/molecules26061773. [PMID: 33809943]
  • Ankur Kumar Tanwar, Neha Dhiman, Amit Kumar, Vikas Jaitak. Engagement of phytoestrogens in breast cancer suppression: Structural classification and mechanistic approach. European journal of medicinal chemistry. 2021 Mar; 213(?):113037. doi: 10.1016/j.ejmech.2020.113037. [PMID: 33257172]
  • Duraisamy Kempuraj, Ramasamy Thangavel, Deepak D Kempuraj, Mohammad Ejaz Ahmed, Govindhasamy Pushpavathi Selvakumar, Sudhanshu P Raikwar, Smita A Zaheer, Shankar S Iyer, Raghav Govindarajan, Premkumar Nattanmai Chandrasekaran, Asgar Zaheer. Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma. BioFactors (Oxford, England). 2021 Mar; 47(2):190-197. doi: 10.1002/biof.1687. [PMID: 33098588]
  • Shabir Ahmad Ganai, Farooq Ahmad Sheikh, Zahoor Ahmad Baba. Plant flavone Chrysin as an emerging histone deacetylase inhibitor for prosperous epigenetic-based anticancer therapy. Phytotherapy research : PTR. 2021 Feb; 35(2):823-834. doi: 10.1002/ptr.6869. [PMID: 32930436]
  • Jun-Yan Xiang, Yan-Yu Chi, Jin-Xin Han, Hongyu Xiang, Qiuhong Xie. The Toxicity and Attenuation Methods of Toxic Chinese Materia Medica for its Reasonable Application: A Review. The American journal of Chinese medicine. 2021; 49(1):41-67. doi: 10.1142/s0192415x21500038. [PMID: 33416023]
  • Annelie Gutsch, Sophie Hendrix, Gea Guerriero, Jenny Renaut, Stanley Lutts, Saleh Alseekh, Alisdair R Fernie, Jean-Francois Hausman, Jaco Vangronsveld, Ann Cuypers, Kjell Sergeant. Long-Term Cd Exposure Alters the Metabolite Profile in Stem Tissue of Medicago sativa. Cells. 2020 12; 9(12):. doi: 10.3390/cells9122707. [PMID: 33348837]
  • Xin Huang, Junxiang Zhu, Li Wang, Huijuan Jing, Chaoyang Ma, Xingran Kou, Hongxin Wang. Inhibitory mechanisms and interaction of tangeretin, 5-demethyltangeretin, nobiletin, and 5-demethylnobiletin from citrus peels on pancreatic lipase: Kinetics, spectroscopies, and molecular dynamics simulation. International journal of biological macromolecules. 2020 Dec; 164(?):1927-1938. doi: 10.1016/j.ijbiomac.2020.07.305. [PMID: 32795575]
  • Mao Seoka, Gang Ma, Lancui Zhang, Masaki Yahata, Kazuki Yamawaki, Toshiyuki Kan, Masaya Kato. Expression and functional analysis of the nobiletin biosynthesis-related gene CitOMT in citrus fruit. Scientific reports. 2020 09; 10(1):15288. doi: 10.1038/s41598-020-72277-z. [PMID: 32943728]
  • Hayat Kherkhache, Imane Benabdelaziz, Artur M S Silva, Mokhtar Boualem Lahrech, Mokhtar Benalia, Hamada Haba. A new indole alkaloid, antioxidant and antibacterial activities of crude extracts from Saccocalyx satureioides. Natural product research. 2020 Jun; 34(11):1528-1534. doi: 10.1080/14786419.2018.1519817. [PMID: 30445859]
  • Chao Niu, Jia Sun, Yongquan Zheng, Linlin Wang, Jian Zhang, Ruijie Chen, Weijian Ye. Determination of isosinensetin in rat plasma by UHPLC-MS/MS: Application to oral and intravenous pharmacokinetic study in healthy rats. Journal of pharmaceutical and biomedical analysis. 2020 May; 184(?):113210. doi: 10.1016/j.jpba.2020.113210. [PMID: 32126459]
  • Weidong Dai, Zhengyan Hu, Dongchao Xie, Junfeng Tan, Zhi Lin. A novel spatial-resolution targeted metabolomics method in a single leaf of the tea plant (Camellia sinensis). Food chemistry. 2020 May; 311(?):126007. doi: 10.1016/j.foodchem.2019.126007. [PMID: 31855776]
  • Wenzhen Zhu, Yanping Zhu, Huan Xu, Ting Wang, Jing Wang, Min Meng, Ying Liu, Han Yan, Qiaozhi Yang, Peiman Liu. Flavone inhibited proliferation of T-ALL by promoting c-Cbl-induced ubiquitinylation and degradation of Notch1. Biochemical and biophysical research communications. 2020 02; 522(3):684-689. doi: 10.1016/j.bbrc.2019.11.148. [PMID: 31785807]
  • Ninh The Son, Midori Suenaga, Yoiichi Matsunaga, Luu Van Chinh, Miwa Kubo, Kenichi Harada, Nguyen Manh Cuong, Yoshiyasu Fukuyama. Serine protease inhibitors and activators from Dalbergia tonkinensis species. Journal of natural medicines. 2020 Jan; 74(1):257-263. doi: 10.1007/s11418-019-01347-y. [PMID: 31352545]
  • Liang Zhang. Pharmacokinetics and drug delivery systems for puerarin, a bioactive flavone from traditional Chinese medicine. Drug delivery. 2019 Dec; 26(1):860-869. doi: 10.1080/10717544.2019.1660732. [PMID: 31524010]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
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