Carnitine (BioDeep_00000000070)

 

Secondary id: BioDeep_00000016570, BioDeep_00000018399, BioDeep_00000399939, BioDeep_00000400234

natural product PANOMIX_OTCML-2023 human metabolite Endogenous blood metabolite Chemicals and Drugs BioNovoGene_Lab2019


代谢物信息卡片


(3R)-3-hydroxy-4-(trimethylazaniumyl)butanoate

化学式: C7H15NO3 (161.1052)
中文名称: 左旋肉碱, 肉碱
谱图信息: 最多检出来源 Homo sapiens(plant) 13%

Reviewed

Last reviewed on 2024-06-29.

Cite this Page

Carnitine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/carnitine (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000000070). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C[N+](C)(C)CC(CC(=O)[O-])O
InChI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3

描述信息

(R)-carnitine is the (R)-enantiomer of carnitine. It has a role as an antilipemic drug, a water-soluble vitamin (role), a nutraceutical, a nootropic agent and a Saccharomyces cerevisiae metabolite. It is a conjugate base of a (R)-carnitinium. It is an enantiomer of a (S)-carnitine.
Constituent of striated muscle and liver. It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias.
L-Carnitine is a metabolite found in or produced by Escherichia coli (strain K12, MG1655).
Levocarnitine is a Carnitine Analog.
Levocarnitine is a natural product found in Mucidula mucida, Pseudo-nitzschia multistriata, and other organisms with data available.
Levocarnitine is an amino acid derivative. Levocarnitine facilitates long-chain fatty acid entry into mitochondria, delivering substrate for oxidation and subsequent energy production. Fatty acids are utilized as an energy substrate in all tissues except the brain. (NCI04)
Carnitine is not an essential amino acid; it can be synthesized in the body. However, it is so important in providing energy to muscles including the heart-that some researchers are now recommending carnitine supplements in the diet, particularly for people who do not consume much red meat, the main food source for carnitine. Carnitine has been described as a vitamin, an amino acid, or a metabimin, i.e., an essential metabolite. Like the B vitamins, carnitine contains nitrogen and is very soluble in water, and to some researchers carnitine is a vitamin (Liebovitz 1984). It was found that an animal (yellow mealworm) could not grow without carnitine in its diet. However, as it turned out, almost all other animals, including humans, do make their own carnitine; thus, it is no longer considered a vitamin. Nevertheless, in certain circumstances-such as deficiencies of methionine, lysine or vitamin C or kidney dialysis--carnitine shortages develop. Under these conditions, carnitine must be absorbed from food, and for this reason it is sometimes referred to as a metabimin or a conditionally essential metabolite. Like the other amino acids used or manufactured by the body, carnitine is an amine. But like choline, which is sometimes considered to be a B vitamin, carnitine is also an alcohol (specifically, a trimethylated carboxy-alcohol). Thus, carnitine is an unusual amino acid and has different functions than most other amino acids, which are most usually employed by the body in the construction of protein. Carnitine is an essential factor in fatty acid metabolism in mammals. Its most important known metabolic function is to transport fat into the mitochondria of muscle cells, including those in the heart, for oxidation. This is how the heart gets most of its energy. In humans, about 25\\\\\% of carnitine is synthesized in the liver, kidney and brain from the amino acids lysine and methionine. Most of the carnitine in the body comes from dietary sources such as red meat and dairy products. Inborn errors of carnitine metabolism can lead to brain deterioration like that of Reyes syndrome, gradually worsening muscle weakness, Duchenne-like muscular dystrophy and extreme muscle weakness with fat accumulation in muscles. Borurn et al. (1979) describe carnitine as an essential nutrient for pre-term babies, certain types (non-ketotic) of hypoglycemics, kidney dialysis patients, cirrhosis, and in kwashiorkor, type IV hyperlipidemia, heart muscle disease (cardiomyopathy), and propionic or organic aciduria (acid urine resulting from genetic or other anomalies). In all these conditions and the inborn errors of carnitine metabolism, carnitine is essential to life and carnitine supplements are valuable. carnitine therapy may also be useful in a wide variety of clinical conditions. carnitine supplementation has improved some patients who have angina secondary to coronary artery disease. It may be worth a trial in any form of hyperlipidemia or muscle weakness. carnitine supplements may...

(-)-Carnitine. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=541-15-1 (retrieved 2024-06-29) (CAS RN: 541-15-1). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
L-Carnitine ((R)-Carnitine), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine is an antioxidant. L-Carnitine can ameliorate metabolic imbalances in many inborn errors of metabolism[1][2][3].
L-Carnitine ((R)-Carnitine), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine is an antioxidant. L-Carnitine can ameliorate metabolic imbalances in many inborn errors of metabolism[1][2][3].

同义名列表

128 个代谢物同义名

1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, hydroxide, inner salt, (R)-; Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, hydroxide, inner salt, L- (8CI); Levocarnitine, Pharmaceutical Secondary Standard; Certified Reference Material; 1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, inner salt, (2R)- (9CI); 1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, hydroxide, inner salt; Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, hydroxide, inner salt, L-; 3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium hydroxide, inner salt; 1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, inner salt, (2R)-; 1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, inner salt, (R)-; (R)-(3-Carboxy-2-hydroxypropyl)trimethylammonium hydroxide, inner salt; Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, hydroxide,inner salt; (L-3-Carboxy-2-hydroxypropyl)trimethylammonium hydroxide, inner salt; (3-Carboxy-2-hydroxypropyl)trimethyl-ammonium hydroxide, inner salt; (2r)-3-carboxy-2-hydroxy-n,n,n-trimethyl-1-propanaminium inner salt; Levocarnitine, United States Pharmacopeia (USP) Reference Standard; Levocarnitine, European Pharmacopoeia (EP) Reference Standard; (-)-(R)-3-Hydroxy-4-(trimethylammonio)butyrate, Vitamin BT; (R)-(3-Carboxy-2-hydroxypropyl)trimethylammonium hydroxide; R(-)-beta-Hydroxy-gamma-(N,N,N-trimethylammonio)butyrate; (3R)-3-hydroxy-4-(trimethylammonio)butanoate;L-Carnitine; 1-Propanaminium,3-carboxy-2-hydroxy-N,N,N-trimethyl-; 3-carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium; Levocarnitine Oral Solution (Suguar Free) 1 g/10 mL; beta-Hydroxy-gamma-N,N,N-trimethylammoniobutyrate; (3R)-(-)-3-Hydroxy-4-(trimethylammonio)butanoate; (3R)-3-hydroxy-4-(trimethylazaniumyl)butanoate; (-)-(R)-3-Hydroxy-4-(trimethylammonio)butyrate; gamma-Trimethyl-ammonium-beta-hydroxybutirate; (3R)-3-hydroxy-4-(trimethylammonio)butanoate; gamma-L-trimethyl-beta-hydroxybutyrobetaine; (R)-3-hydroxy-4-(trimethylammonio)butanoate; L-gamma-trimethyl-beta-hydroxybutyrobetaine; (R)-3-Hydroxy-4-(trimethylammonio)butyrate; 3-hydroxy-4-trimethylammoniobutanoic acid; gamma-Trimethyl-beta-hydroxybutyrobetaine; L-Carnitine inner salt, synthetic, >=98\\%; (R)-3-Hydroxy-4-trimethylammoniobutanoate; R-(-)-3-hydroxy-4-trimethylaminobutyrate; 3-Hydroxy-4-(trimethylammonio) butanoate; (R)-3-Hydroxy-4-trimethylammoniobutyrate; 3-hydroxy-4-trimethylammoniobutanoate; gamma-Trimethyl-hydroxybutyrobetaine; Levocarnitine (USAN:USP:INN:BAN); Levocarnitine [USAN:USP:INN:BAN]; Carnitine dl-form hydrochloride; 6-CHLORO-3-HYDROXY(1H)INDAZOLE; LEVOCARNITINE (USP MONOGRAPH); LEVOCARNITINE [USP MONOGRAPH]; LEVOCARNITINE (EP MONOGRAPH); CARNITINE HYDROCHLORIDE, DL-; LEVOCARNITINE [EP MONOGRAPH]; Levocarnitine Oral Solution; LEVOCARNITINE [ORANGE BOOK]; L-carnitine (Levocarnitine); Levocarnitine (JAN/USP/INN); Levocarnitine [USAN:INN]; Levocarnitina [Spanish]; L-Carnitine inner salt; LEVOCARNITINE [USP-RS]; LEVOCARNITINE [WHO-DD]; Levocarnitinum [Latin]; LEVOCARNITINE (USP-RS); Levocarnitinum (Latin); LEVOCARNITINE [MART.]; LEVOCARNITINE (MART.); LEVOCARNITINE [VANDF]; LEVOCARNITINE [HSDB]; LEVOCARNITINE [USAN]; LEVOCARNITINE [JAN]; LEVOCARNITINE [INN]; L-CARNITINE [VANDF]; carnitine (L-form); levocarnitine HCl; L-CARNITINE [FCC]; LEVOCARNITINE SF; L-carnitine Base; L-Carnitine,(S); UNII-0G389FZZ9M; L-(-)-Carnitine; Carnitine, (-)-; delta-carnitine; (-)-L-Carnitine; Levocarnitinum; L(-)-Carnitine; CARNITINE [MI]; Carnitine, L-; Levocarnitine; Levocarnitina; (R)-Carnitine; Carnitine HCl; (-)-Carnitine; Carnitor (TN); Carnipass 20; Levocarnitin; Carniking 50; Carnitor SF; L Carnitine; bicarnesine; 1-CARNITINE; Oristar lch; vitamin B T; L-carnitine; Nefrocarnit; L-Carnitin; 0G389FZZ9M; Levocarnil; vitamin BT; Carnipass; Carnitine; Carnitolo; Carnitene; Carniking; Carnilean; Carnitor; Karnitin; Carnicor; Carnovis; Carrier; A16AA01; Metina; L-Carn; Lefcar; L-Carnitine hydrochloride; (S)-Carnitine; DL-Carnitine; D-Carnitine; Carnitine; L-Carnitine



数据库引用编号

47 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(17)

BioCyc(6)

PlantCyc(0)

代谢反应

225 个相关的代谢反应过程信息。

Reactome(136)

BioCyc(23)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(4)

COVID-19 Disease Map(0)

PathBank(62)

PharmGKB(0)

120 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ACADM, AKT1, ALB, MTOR, PRKAA2, SLC22A5
Peripheral membrane protein 2 CPT2, MTOR
Endoplasmic reticulum membrane 2 CD4, MTOR
Mitochondrion membrane 1 SLC22A4
Nucleus 5 ACADM, AKT1, ALB, MTOR, PRKAA2
cytosol 9 AKT1, ALB, BBOX1, GPT, MB, MTOR, PRKAA2, PRKCQ, SLC22A5
dendrite 2 MTOR, PRKAA2
mitochondrial membrane 2 ACADM, SLC22A4
phagocytic vesicle 1 MTOR
centrosome 2 ALB, SLC16A1
nucleoplasm 4 AKT1, CPT2, MTOR, PRKAA2
Cell membrane 4 AKT1, CD4, SLC16A1, SLC22A5
Cytoplasmic side 1 MTOR
lamellipodium 1 AKT1
Multi-pass membrane protein 4 SLC16A1, SLC22A2, SLC22A4, SLC22A5
Golgi apparatus membrane 1 MTOR
Synapse 1 SLC16A1
cell cortex 1 AKT1
cell junction 1 SLC16A1
cell surface 1 EPO
glutamatergic synapse 1 AKT1
Golgi apparatus 2 ALB, PRKAA2
Golgi membrane 2 INS, MTOR
lysosomal membrane 1 MTOR
mitochondrial inner membrane 1 CPT2
neuronal cell body 1 PRKAA2
postsynapse 1 AKT1
Lysosome 1 MTOR
Presynapse 1 SLC22A2
plasma membrane 8 AKT1, CD4, GCG, PRKCQ, SLC16A1, SLC22A2, SLC22A4, SLC22A5
Membrane 7 AKT1, MTOR, PRKAA2, SLC16A1, SLC22A2, SLC22A4, SLC22A5
apical plasma membrane 4 SLC16A1, SLC22A2, SLC22A4, SLC22A5
axon 2 ACADM, PRKAA2
basolateral plasma membrane 2 SLC16A1, SLC22A2
extracellular exosome 8 ALB, BBOX1, EPO, GPT, MB, SLC16A1, SLC22A2, SLC22A5
Lysosome membrane 1 MTOR
endoplasmic reticulum 2 ALB, SLC22A5
extracellular space 6 ALB, CRP, EPO, GCG, INS, LPA
mitochondrion 4 ACADM, BBOX1, CPT2, SLC22A4
protein-containing complex 2 AKT1, ALB
intracellular membrane-bounded organelle 1 SLC16A1
Microsome membrane 1 MTOR
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 CD4
Secreted 5 ALB, CRP, EPO, GCG, INS
extracellular region 6 ALB, CRP, EPO, GCG, INS, LPA
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 1 MTOR
Mitochondrion matrix 1 ACADM
mitochondrial matrix 1 ACADM
anchoring junction 1 ALB
centriolar satellite 1 PRKCQ
external side of plasma membrane 1 CD4
microtubule cytoskeleton 1 AKT1
nucleolus 1 CPT2
sarcoplasm 1 MB
Early endosome 1 CD4
cell-cell junction 1 AKT1
vesicle 1 AKT1
Apical cell membrane 4 SLC16A1, SLC22A2, SLC22A4, SLC22A5
Mitochondrion inner membrane 1 CPT2
Matrix side 1 CPT2
Membrane raft 1 CD4
spindle 1 AKT1
Nucleus, PML body 1 MTOR
PML body 1 MTOR
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
lateral plasma membrane 1 SLC16A1
nuclear speck 1 PRKAA2
ciliary basal body 2 AKT1, ALB
centriole 1 ALB
brush border membrane 1 SLC22A5
spindle pole 1 ALB
blood microparticle 1 ALB
Basolateral cell membrane 2 SLC16A1, SLC22A2
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
endosome lumen 1 INS
cytoplasmic stress granule 1 PRKAA2
cell body 1 EPO
basal plasma membrane 4 SLC16A1, SLC22A2, SLC22A4, SLC22A5
secretory granule lumen 3 EPO, GCG, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, CD4, GCG, INS
platelet alpha granule lumen 1 ALB
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
clathrin-coated endocytic vesicle membrane 1 CD4
Basal cell membrane 3 SLC22A2, SLC22A4, SLC22A5
nucleotide-activated protein kinase complex 1 PRKAA2
Cytoplasmic vesicle, phagosome 1 MTOR
[Isoform 3]: Endoplasmic reticulum 1 SLC22A5
[Glucagon-like peptide 1]: Secreted 1 GCG
T cell receptor complex 1 CD4
Cytoplasm, sarcoplasm 1 MB
plasma lipoprotein particle 1 LPA
ciliary transition fiber 1 ALB


文献列表

  • Kie Sekiguchi, Takaya Abe, Ei Shiomi, Daiki Ikarashi, Tomohiko Matsuura, Shigekatsu Maekawa, Renpei Kato, Mitsugu Kanehira, Ryo Takata, Jun Sugimura, Takashi Sekiguchi, Wataru Obara. Abnormal carnitine metabolism in hemodialysis patients on different anticoagulants. Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy. 2024 Jun; 28(3):364-370. doi: 10.1111/1744-9987.14096. [PMID: 38087844]
  • Junyan Lyu, Hikari Okada, Hajime Sunagozaka, Kazunori Kawaguchi, Tetsuro Shimakami, Kouki Nio, Kazuhisa Murai, Takayoshi Shirasaki, Mika Yoshida, Kuniaki Arai, Tatsuya Yamashita, Takuji Tanaka, Kenichi Harada, Toshinari Takamura, Shuichi Kaneko, Taro Yamashita, Masao Honda. Potential utility of l-carnitine for preventing liver tumors derived from metabolic dysfunction-associated steatohepatitis. Hepatology communications. 2024 May; 8(5):. doi: 10.1097/hc9.0000000000000425. [PMID: 38619434]
  • Jiayu Jing, Cui Zhang, Sihao Du, Xiaohui Tan, Xia Yue, Dongfang Qiao. Sudden death with cardiac involvement in a neonate with carnitine-acylcarnitine translocase deficiency. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. 2024 May; 70(?):107630. doi: 10.1016/j.carpath.2024.107630. [PMID: 38490313]
  • Yuichi Suzuki, Shuntaro Itagaki, Maki Nodera, Kazuhide Suyama, Hirooki Yabe, Mitsuaki Hosoya. Comparison of metabolic parameters between oral and total parenteral nutrition in children with severe eating disorders. Fukushima journal of medical science. 2024 Apr; 70(2):75-85. doi: 10.5387/fms.2023-02. [PMID: 38599829]
  • Yeon-Hee Kim, Jin-Soo Chung, Hyung-Ho Lee, Jin-Hee Park, Mi-Kyung Kim. Influence of Dietary Polyunsaturated Fatty Acid Intake on Potential Lipid Metabolite Diagnostic Markers in Renal Cell Carcinoma: A Case-Control Study. Nutrients. 2024 Apr; 16(9):. doi: 10.3390/nu16091265. [PMID: 38732512]
  • Amany E Nofal, Hind S AboShabaan, Walaa A Fadda, Rafik E Ereba, Sherin M Elsharkawy, Heba M Hathout. L-carnitine and Ginkgo biloba Supplementation In Vivo Ameliorates HCD-Induced Steatohepatitis and Dyslipidemia by Regulating Hepatic Metabolism. Cells. 2024 Apr; 13(9):. doi: 10.3390/cells13090732. [PMID: 38727268]
  • Ruijie Guo, Kai Huang, Kai Yu, Jinghua Li, Jiao Huang, Dandan Wang, Yuda Li. Effects of Fat and Carnitine on the Expression of Carnitine Acetyltransferase and Enoyl-CoA Hydratase Short-Chain 1 in the Liver of Juvenile GIFT (Oreochromis niloticus). Genes. 2024 Apr; 15(4):. doi: 10.3390/genes15040480. [PMID: 38674414]
  • Haiyang Kou, Bo Li, Zhili Wang, Jianbing Ma. Effect of l-Carnitine Supplementation on Osteoarthritis: A Systematic Review. Molecular nutrition & food research. 2024 Apr; 68(8):e2300614. doi: 10.1002/mnfr.202300614. [PMID: 38389158]
  • Zhou Liang, Hongsheng He, Bing Zhang, Zhentian Kai, Liang Zong. Hypoxia expedites the progression of papillary thyroid carcinoma by promoting the CPT1A-mediated fatty acid oxidative pathway. Drug development research. 2024 Apr; 85(2):e22168. doi: 10.1002/ddr.22168. [PMID: 38450796]
  • Caleigh M Sawicki, Lorena S Pacheco, Sona Rivas-Tumanyan, Zheyi Cao, Danielle E Haslam, Liming Liang, Katherine L Tucker, Kaumudi Joshipura, Shilpa N Bhupathiraju. Association of Gut Microbiota-Related Metabolites and Type 2 Diabetes in Two Puerto Rican Cohorts. Nutrients. 2024 Mar; 16(7):. doi: 10.3390/nu16070959. [PMID: 38612993]
  • Qing Li, Tianle Chao, Yanyan Wang, Rong Xuan, Yanfei Guo, Peipei He, Lu Zhang, Jianmin Wang. Comparative metabolomics reveals serum metabolites changes in goats during different developmental stages. Scientific reports. 2024 03; 14(1):7291. doi: 10.1038/s41598-024-57803-7. [PMID: 38538719]
  • Kuiliang Zhang, Lei Jiang, Lamei Xue, Yu Wang, Yujie Sun, Mingcong Fan, Haifeng Qian, Li Wang, Yan Li. 5-Heptadecylresorcinol Improves Aging-Associated Hepatic Fatty Acid Oxidation Dysfunction via Regulating Adipose Sirtuin 3. Nutrients. 2024 Mar; 16(7):. doi: 10.3390/nu16070978. [PMID: 38613012]
  • Yang Yang, Huaifeng Li, Ke Liu, Lu Zou, Shanshan Xiang, Yajun Geng, Xuechuan Li, Shimei Qiu, Jiahua Yang, Xuya Cui, Lin Li, Yang Li, Weijian Li, Siyuan Yan, Liguo Liu, Xiangsong Wu, Fatao Liu, Wenguang Wu, Shili Chen, Yingbin Liu. Acylcarnitines promote gallbladder cancer metastasis through lncBCL2L11-THOC5-JNK axis. Journal of translational medicine. 2024 Mar; 22(1):299. doi: 10.1186/s12967-024-05091-0. [PMID: 38519939]
  • Ting Hu, Wen Zhang, Feifei Han, Rui Zhao, Hongchuan Liu, Zhuoling An. Machine learning reveals serum myristic acid, palmitic acid and heptanoylcarnitine as biomarkers of coronary artery disease risk in patients with type 2 diabetes mellitus. Clinica chimica acta; international journal of clinical chemistry. 2024 Mar; 556(?):117852. doi: 10.1016/j.cca.2024.117852. [PMID: 38438006]
  • Tobias Harm, Xiaoqing Fu, Moritz Frey, Kristina Dittrich, Adrian Brun, Tatsiana Castor, Oliver Borst, Karin Anne Lydia Müller, Tobias Geisler, Dominik Rath, Michael Lämmerhofer, Meinrad Paul Gawaz. Machine learning insights into thrombo-ischemic risks and bleeding events through platelet lysophospholipids and acylcarnitine species. Scientific reports. 2024 03; 14(1):6089. doi: 10.1038/s41598-024-56304-x. [PMID: 38480746]
  • Lei Ma, Chong Chen, Chunxing Zhao, Tong Li, Lingyu Ma, Jiayu Jiang, Zhaojun Duan, Qin Si, Tsung-Hsien Chuang, Rong Xiang, Yunping Luo. Targeting carnitine palmitoyl transferase 1A (CPT1A) induces ferroptosis and synergizes with immunotherapy in lung cancer. Signal transduction and targeted therapy. 2024 Mar; 9(1):64. doi: 10.1038/s41392-024-01772-w. [PMID: 38453925]
  • Marit Schwantje, Signe Mosegaard, Suzan J G Knottnerus, Jan Bert van Klinken, Ronald J Wanders, Henk van Lenthe, Jill Hermans, Lodewijk IJlst, Simone W Denis, Yorrick R J Jaspers, Sabine A Fuchs, Riekelt H Houtkooper, Sacha Ferdinandusse, Frédéric M Vaz. Tracer-based lipidomics enables the discovery of disease-specific candidate biomarkers in mitochondrial β-oxidation disorders. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2024 Feb; 38(4):e23478. doi: 10.1096/fj.202302163r. [PMID: 38372965]
  • Kristina Vacy, Sarah Thomson, Archer Moore, Alex Eisner, Sam Tanner, Cindy Pham, Richard Saffery, Toby Mansell, David Burgner, Fiona Collier, Peter Vuillermin, Martin O'Hely, Wah Chin Boon, Peter Meikle, Satvika Burugupalli, Anne-Louise Ponsonby. Cord blood lipid correlation network profiles are associated with subsequent attention-deficit/hyperactivity disorder and autism spectrum disorder symptoms at 2 years: a prospective birth cohort study. EBioMedicine. 2024 Feb; 100(?):104949. doi: 10.1016/j.ebiom.2023.104949. [PMID: 38199043]
  • Wei Li, Yanqing Zhang, Jing Zhao, Tan Yang, Junbo Xie. L-carnitine modified nanoparticles target the OCTN2 transporter to improve the oral absorption of jujuboside B. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2024 Jan; ?(?):114185. doi: 10.1016/j.ejpb.2024.114185. [PMID: 38280469]
  • Ross Summer, Jamie L Todd, Megan L Neely, L Jason Lobo, Andrew Namen, L Kristin Newby, Shirin Shafazand, Sally Suliman, Christian Hesslinger, Sascha Keller, Thomas B Leonard, Scott M Palmer, Olga Ilkayeva, Michael J Muehlbauer, Christopher B Newgard, Jesse Roman. Circulating metabolic profile in idiopathic pulmonary fibrosis: data from the IPF-PRO Registry. Respiratory research. 2024 Jan; 25(1):58. doi: 10.1186/s12931-023-02644-7. [PMID: 38273290]
  • Gabriela Ramos Leal, Thais de Almeida Oliveira, Mariana Pedrosa de Paula Guimarães, Lucas Francisco Leodido Correia, Erlandia Márcia Vasconcelos, Joanna Maria Gonçalves Souza-Fabjan. Lipid modulation during IVM increases the metabolism and improves the cryosurvival of cat oocytes. Theriogenology. 2024 Jan; 214(?):33-42. doi: 10.1016/j.theriogenology.2023.10.001. [PMID: 37839095]
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