Lycopene (BioDeep_00000409930)

Main id: BioDeep_00000000571

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


(6E,8E,10E,12E,14E,16E,18E,20E,22E,24E,26E)-2,6,10,14,19,23,27,31-octamethyldotriaconta-2,6,8,10,12,14,16,18,20,22,24,26,30-tridecaene

化学式: C40H56 (536.4382)
中文名称: 番茄红素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=CCC/C(=C/C=C/C(=C/C=C/C(=C/C=C/C=C(/C=C/C=C(/C=C/C=C(/CCC=C(C)C)\C)\C)\C)/C)/C)/C)C
InChI: InChI=1S/C40H56/c1-33(2)19-13-23-37(7)27-17-31-39(9)29-15-25-35(5)21-11-12-22-36(6)26-16-30-40(10)32-18-28-38(8)24-14-20-34(3)4/h11-12,15-22,25-32H,13-14,23-24H2,1-10H3/b12-11+,25-15+,26-16+,31-17+,32-18+,35-21+,36-22+,37-27+,38-28+,39-29+,40-30+

描述信息

Lycopene, also known as all-trans-lycopene or e160d, is a member of the class of compounds known as carotenes. Carotenes are a type of unsaturated hydrocarbons containing eight consecutive isoprene units. They are characterized by the presence of two end-groups (mostly cyclohexene rings, but also cyclopentene rings or acyclic groups) linked by a long branched alkyl chain. Carotenes belonging form a subgroup of the carotenoids family. Thus, lycopene is considered to be an isoprenoid lipid molecule. Lycopene can be found in a number of food items such as american butterfish, babassu palm, scup, and condensed milk, which makes lycopene a potential biomarker for the consumption of these food products. Lycopene can be found primarily in blood and breast milk, as well as throughout most human tissues. Moreover, lycopene is found to be associated with endometrial cancer. In plants, algae, and other photosynthetic organisms, lycopene is an intermediate in the biosynthesis of many carotenoids, including beta-carotene, which is responsible for yellow, orange, or red pigmentation, photosynthesis, and photoprotection. Like all carotenoids, lycopene is a tetraterpene. It is insoluble in water. Eleven conjugated double bonds give lycopene its deep red color. Owing to the strong color, lycopene is a useful as a food coloring (registered as E160d) and is approved for use in the USA, Australia and New Zealand (registered as 160d) and the European Union .
D020011 - Protective Agents > D000975 - Antioxidants > D002338 - Carotenoids
D020011 - Protective Agents > D011837 - Radiation-Protective Agents
D020011 - Protective Agents > D016588 - Anticarcinogenic Agents
D000893 - Anti-Inflammatory Agents
D000970 - Antineoplastic Agents
Window width to select the precursor ion was 3 Da.; This record was created by the financial support of MEXT/JSPS KAKENHI Grant Number 16HP2005 to the Mass Spectrometry Society of Japan.

同义名列表

36 个代谢物同义名

all-trans-lycopene; Lycopene; (6E,8E,10E,12E,14E,16E,18E,20E,22E,24E,26E)-2,6,10,14,19,23,27,31-octamethyldotriaconta-2,6,8,10,12,14,16,18,20,22,24,26,30-tridecaene; 2,6,10,14,19,23,27,31-Octamethyl-dotriaconta-2,6,8,10,12,14,16,18,20,22,24,26,30-tridecaene; 2,6,10,14,19,23,27,31-octamethyldotriaconta-2,6,8,10,12,14,16,18,20,22,24,26,30-tridecaene; Lycopene, all-trans- (8CI); Lycopene all-trans-; Natural yellow 27; Psi,psi-carotene; Spectrum3_001805; Spectrum4_001998; EINECS 207-949-1; Spectrum_001666; NCGC00166291-01; trans-Lycopene; Lycopene (VAN); KBioGR_002563; KBioSS_002146; BSPBio_003389; NCI60_003882; KBio2_004714; KBio3_002892; LMPR01070257; KBio2_007282; KBio2_002146; L9879_SIGMA; CHEBI:15948; Lycopene 7; CCRIS 7925; C.I. 75125; NSC 407322; CI 75125; 502-65-8; C05432; LYC; Lycopene



数据库引用编号

19 个数据库交叉引用编号

分类词条

213 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 AKT1, ALB, CASP9, CAT, CCND1, GGPS1, GPX1, MSMP, MTOR, NFE2L2, PIK3CA, RUNX2, VEGFA
Peripheral membrane protein 1 MTOR
Endoplasmic reticulum membrane 2 HMGCR, MTOR
Nucleus 9 AKT1, ALB, CASP9, CCND1, KLK3, MTOR, NFE2L2, RUNX2, VEGFA
cytosol 11 AKT1, ALB, CASP9, CAT, CCND1, GGPS1, GPX1, MTOR, NFE2L2, PIK3CA, RUNX2
dendrite 1 MTOR
phagocytic vesicle 2 MTOR, STX8
trans-Golgi network 1 STX8
centrosome 3 ALB, CCND1, NFE2L2
nucleoplasm 6 AKT1, CCND1, GGPS1, MTOR, NFE2L2, RUNX2
RNA polymerase II transcription regulator complex 1 NFE2L2
Cell membrane 1 AKT1
Cytoplasmic side 1 MTOR
lamellipodium 2 AKT1, PIK3CA
Multi-pass membrane protein 1 HMGCR
Golgi apparatus membrane 1 MTOR
cell cortex 1 AKT1
cell surface 1 VEGFA
glutamatergic synapse 1 AKT1
Golgi apparatus 3 ALB, NFE2L2, VEGFA
Golgi membrane 1 MTOR
lysosomal membrane 1 MTOR
postsynapse 1 AKT1
Cytoplasm, cytosol 1 NFE2L2
Lysosome 1 MTOR
endosome 1 STX8
plasma membrane 6 AKT1, IFNLR1, KLK3, NFE2L2, PIK3CA, STX8
Membrane 7 AKT1, CAT, HMGCR, IFNLR1, MTOR, STX8, VEGFA
extracellular exosome 3 ALB, CAT, KLK3
Lysosome membrane 1 MTOR
endoplasmic reticulum 4 ALB, HMGCR, STX8, VEGFA
extracellular space 7 ALB, CCL2, CRP, IGF1, KLK3, MSMP, VEGFA
perinuclear region of cytoplasm 3 GGPS1, PIK3CA, STX8
adherens junction 1 VEGFA
bicellular tight junction 1 CCND1
intercalated disc 1 PIK3CA
mitochondrion 3 CASP9, CAT, GPX1
protein-containing complex 5 AKT1, ALB, CASP9, CAT, KLK3
intracellular membrane-bounded organelle 1 CAT
Microsome membrane 1 MTOR
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 IFNLR1
Secreted 6 ALB, CCL2, CRP, IGF1, MSMP, VEGFA
extracellular region 7 ALB, CAT, CCL2, CRP, IGF1, KLK3, VEGFA
Mitochondrion outer membrane 1 MTOR
Single-pass membrane protein 1 STX8
mitochondrial outer membrane 1 MTOR
mitochondrial matrix 2 CAT, GPX1
anchoring junction 1 ALB
transcription regulator complex 1 RUNX2
Nucleus membrane 1 CCND1
nuclear membrane 1 CCND1
Secreted, extracellular space, extracellular matrix 1 VEGFA
Z disc 1 GGPS1
microtubule cytoskeleton 1 AKT1
Early endosome 1 STX8
cell-cell junction 1 AKT1
recycling endosome 1 STX8
vesicle 2 AKT1, STX8
Cytoplasm, perinuclear region 1 GGPS1
focal adhesion 1 CAT
spindle 1 AKT1
extracellular matrix 1 VEGFA
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 2 CAT, HMGCR
Nucleus, PML body 1 MTOR
PML body 1 MTOR
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 2 KLK3, VEGFA
Late endosome 1 STX8
ciliary basal body 2 AKT1, ALB
chromatin 2 NFE2L2, RUNX2
mediator complex 1 NFE2L2
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
nuclear envelope 1 MTOR
Endomembrane system 2 MTOR, STX8
Peroxisome membrane 1 HMGCR
Cytoplasm, myofibril, sarcomere, Z line 1 GGPS1
SNARE complex 1 STX8
exocytic vesicle 1 IGF1
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
endoplasmic reticulum lumen 1 ALB
transcription repressor complex 1 CCND1
platelet alpha granule lumen 3 ALB, IGF1, VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
Single-pass type IV membrane protein 1 STX8
apoptosome 1 CASP9
protein-DNA complex 1 NFE2L2
Cytoplasmic vesicle, phagosome 1 MTOR
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
catalase complex 1 CAT
alphav-beta3 integrin-IGF-1-IGF1R complex 1 IGF1
insulin-like growth factor binding protein complex 1 IGF1
insulin-like growth factor ternary complex 1 IGF1
cyclin D1-CDK4 complex 1 CCND1
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
cyclin D1-CDK6 complex 1 CCND1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
ciliary transition fiber 1 ALB
caspase complex 1 CASP9
interleukin-28 receptor complex 1 IFNLR1


文献列表

  • Wencheng Zhang, Ziqiao Ji, Guiqiu Hu, Li Yuan, Man Liu, Xian Zhang, Chunhua Wei, Zuyun Dai, Zhongzhou Yang, Chaonan Wang, Xuezheng Wang, Feishi Luan, Shi Liu. Clpf encodes pentatricopeptide repeat protein (PPR5) and regulates pink flesh color in watermelon (Citrullus lanatus L.). TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik. 2024 May; 137(6):126. doi: 10.1007/s00122-024-04619-8. [PMID: 38727833]
  • Xunyu Song, Jun Sun, Hanxiong Liu, Aroosa Mushtaq, Zhoumei Huang, Daotong Li, Lujia Zhang, Fang Chen. Lycopene Alleviates Endoplasmic Reticulum Stress in Steatohepatitis through Inhibition of the ASK1-JNK Signaling Pathway. Journal of agricultural and food chemistry. 2024 Apr; 72(14):7832-7844. doi: 10.1021/acs.jafc.3c08108. [PMID: 38544357]
  • Buli Su, Peixuan Lai, Ming-Rong Deng, Honghui Zhu. Global rewiring of lipid metabolism to produce carotenoid by deleting the transcription factor genes ino2/ino4 in Saccharomyces cerevisiae. International journal of biological macromolecules. 2024 Apr; 264(Pt 1):130400. doi: 10.1016/j.ijbiomac.2024.130400. [PMID: 38412934]
  • Yanan Zhang, Xiaobing Zhai, Honglin Chai, Keyang Liu, Wenzhi Ma, Shiyang Li, Jing Zeng, Mei Yang, Feng Zhou, Surui Zheng, Xia Wu, Bing Xiang, Jinhong Cao, Ehab S Eshak, Can Jiang. Associations of different isomeric forms of serum lycopene with cardiovascular disease and all-cause mortality. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition. 2024 Apr; 94(2):108-119. doi: 10.1024/0300-9831/a000775. [PMID: 36691936]
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  • Jawaria Jameel, Tauseef Anwar, Saadat Majeed, Huma Qureshi, Ejaz Hussain Siddiqi, Sundas Sana, Wajid Zaman, Hayssam M Ali. Effect of salinity on growth and biochemical responses of brinjal varieties: implications for salt tolerance and antioxidant mechanisms. BMC plant biology. 2024 Feb; 24(1):128. doi: 10.1186/s12870-024-04836-9. [PMID: 38383291]
  • Hao Luo, Yihong Bao, Ping Zhu. Enhancing the functionality of plant-based Yogurt: Integration of lycopene through dual-stage fermentation of soymilk. Food chemistry. 2024 Feb; 434(?):137511. doi: 10.1016/j.foodchem.2023.137511. [PMID: 37742554]
  • Weidong Chen, Yuanqing Li, Min Li, Hai Li, Caifang Chen, Yanzhao Lin. Association between dietary carotenoid intakes and abdominal aortic calcification in adults: National Health and Nutrition Examination Survey 2013-2014. Journal of health, population, and nutrition. 2024 Feb; 43(1):20. doi: 10.1186/s41043-024-00511-9. [PMID: 38303096]
  • Wanrong Wu, Yanchun Shao, Yeting Wu, Yunxia Gong, Xiaoyan Guan, Baixue Liu, Youyou Lu. New Horizons of Covalent Complex of Plant-Derived Recombinant Human Lactoferrin (OsrhLF) Combined with Different Polyphenols: Formation, Physicochemical Properties, and Gastrointestinal Fate. Journal of agricultural and food chemistry. 2024 Jan; ?(?):. doi: 10.1021/acs.jafc.3c06856. [PMID: 38262965]
  • Huimin Ma, Qi Chen, Haiming Yang, Xiaoli Wan. Effects of lycopene on the growth performance, meat quality, and antioxidant capacity of broiler chickens challenged with aflatoxin B1. Journal of food science. 2024 Jan; 89(1):96-103. doi: 10.1111/1750-3841.16848. [PMID: 37983886]
  • Wenhai Guo, Danping Huang, Shaodong Li. Lycopene alleviates oxidative stress-induced cell injury in human vascular endothelial cells by encouraging the SIRT1/Nrf2/HO-1 pathway. Clinical and experimental hypertension (New York, N.Y. : 1993). 2023 Dec; 45(1):2205051. doi: 10.1080/10641963.2023.2205051. [PMID: 37120838]
  • Margarita Aguilar-Espinosa, José Enrique Ek-Ku, Renata Rivera-Madrid, Marina Vera-Ku. Advancing carotenoid Quantification: A new method for semi-quantitative assessment of β -Carotene and lycopene content in food extracts. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2023 Dec; 1231(?):123929. doi: 10.1016/j.jchromb.2023.123929. [PMID: 38035540]
  • Shaohua Yan, Siyu Chen, Yumiao Liu, Hongbin Liang, Xinlu Zhang, Qiuxia Zhang, Jiancheng Xiu. Associations of serum carotenoids with visceral adiposity index and lipid accumulation product: a cross-sectional study based on NHANES 2001-2006. Lipids in health and disease. 2023 Nov; 22(1):209. doi: 10.1186/s12944-023-01945-6. [PMID: 38037060]
  • Jadwiga Hamulka, Agnieszka Sulich, Magdalena Górnicka, Marta Jeruszka-Bielak. Changes in Plasma Carotenoid Concentrations during the AntioxObesity Weight Reduction Program among Adults with Excessive Body Weight. Nutrients. 2023 Nov; 15(23):. doi: 10.3390/nu15234890. [PMID: 38068747]
  • Riccardo Fedeli, Ludovica Marotta, Luca Frattaruolo, Alice Panti, Gabriele Carullo, Fabio Fusi, Simona Saponara, Sandra Gemma, Stefania Butini, Anna Rita Cappello, Andrea Vannini, Giuseppe Campiani, Stefano Loppi. Nutritionally enriched tomatoes (Solanum lycopersicum L.) grown with wood distillate: chemical and biological characterization for quality assessment. Journal of food science. 2023 Nov; ?(?):. doi: 10.1111/1750-3841.16829. [PMID: 37961008]
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  • Ana Arruabarrena, Joanna Lado, Matías González-Arcos, Sabina Vidal. Targeted disruption of tomato chromoplast-specific lycopene β-cyclase (CYC-B) gene promotes early accumulation of lycopene in fruits and enhanced postharvest cold tolerance. Plant biotechnology journal. 2023 Aug; ?(?):. doi: 10.1111/pbi.14169. [PMID: 37654005]
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  • Yage Liu, Yimiao Tian, Xuan Dai, Tianyuan Liu, Yueyi Zhang, Shan Wang, Hanfen Shi, Jiyuan Yin, Tianshu Xu, Ruyuan Zhu, Yanfei Zhang, Dandan Zhao, Sihua Gao, Xiang-Dong Wang, Lili Wang, Dongwei Zhang. Lycopene ameliorates islet function and down-regulates the TLR4/MyD88/NF-κB pathway in diabetic mice and Min6 cells. Food & function. 2023 May; ?(?):. doi: 10.1039/d3fo00559c. [PMID: 37165735]
  • Ya-Hui Wang, Yu-Qing Zhang, Rong-Rong Zhang, Fei-Yun Zhuang, Hui Liu, Zhi-Sheng Xu, Ai-Sheng Xiong. Lycopene ε-cyclase mediated transition of α-carotene and β-carotene metabolic flow in carrot fleshy root. The Plant journal : for cell and molecular biology. 2023 May; ?(?):. doi: 10.1111/tpj.16275. [PMID: 37158657]
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