deferoxamine (BioDeep_00000399828)
Main id: BioDeep_00000006382
natural product
代谢物信息卡片
N-(5-aminopentyl)-N-hydroxy-N-[5-(N-hydroxy-3-{[5-(N-hydroxyacetamido)pentyl]carbamoyl}propanamido)pentyl]butanediamide
化学式: C25H48N6O8 (560.3533)
中文名称: 去铁胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C(=O)N(O)CCCCCNC(CCC(=O)N(O)CCCCCN)=O)CC(=O)NCCCCCN(C(C)=O)O
InChI: InChI=1/C25H48N6O8/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34)
描述信息
V - Various > V03 - All other therapeutic products > V03A - All other therapeutic products > V03AC - Iron chelating agents
D064449 - Sequestering Agents > D002614 - Chelating Agents > D007502 - Iron Chelating Agents
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Deferoxamine (Deferoxamine B) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine upregulates HIF-1α levels with good antioxidant activity. Deferoxamine also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19[1][2][3][4][5].
同义名列表
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:4356
- KEGG: C06940
- KEGGdrug: D03670
- PubChem: 2973
- DrugBank: DB00746
- ChEMBL: CHEMBL556
- LipidMAPS: LMFA08020169
- MeSH: Deferoxamine
- CAS: 1950-39-6
- CAS: 70-51-9
- MoNA: CCMSLIB00005435927
- MoNA: CCMSLIB00003739979
- MoNA: CCMSLIB00000531491
- PubChem: 9155
- PDB-CCD: KTY
- NIKKAJI: J10.199K
- RefMet: Deferoxamine
- medchemexpress: HY-B1625
- KNApSAcK: 4356
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
11 个相关的物种来源信息
- 1886 - Streptomyces albidoflavus:
- 41951 - Streptomyces argillaceus: 10.1371/JOURNAL.PONE.0198145
- 1969 - Streptomyces chartreusis: 10.1073/PNAS.1715713115
- 1902 - Streptomyces coelicolor:
- 47763 - Streptomyces lydicus: 10.1038/SREP44786
- 1428626 - Streptomyces malaysiense: 10.1038/SREP24247
- 92644 - Streptomyces malaysiensis: 10.1038/SREP24247
- 68239 - Streptomyces mirabilis:
- 28893 - Streptomyces pilosus:
- 54571 - Streptomyces venezuelae:
- 141454 - Streptomyces wadayamensis: 10.1128/GENOMEA.00625-14
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jinfu Zhou, Jianping Tang, Chenran Zhang, Guilin Li, Xinpei Lin, Sining Liao, Jinying Luo, Guangxia Yu, Fuli Zheng, Zhenkun Guo, Wenya Shao, Hong Hu, Liangpu Xu, Siying Wu, Huangyuan Li. ALKBH5 targets ACSL4 mRNA stability to modulate ferroptosis in hyperbilirubinemia-induced brain damage.
Free radical biology & medicine.
2024 Aug; 220(?):271-287. doi:
10.1016/j.freeradbiomed.2024.05.014. [PMID: 38734267] - Mahdi Babamir Satehi, Mahdi Karimi, Zohreh Farrokhian, Fateme Pakbaz. The effect of aqueous extract of Iranian oak (Quercus brantii) on antioxidant capacity and oxidative stress in beta-thalassemia patients: Randomized controlled trial.
Clinical nutrition ESPEN.
2024 Jun; 61(?):230-236. doi:
10.1016/j.clnesp.2024.03.037. [PMID: 38777439] - Jing Li, Xiang Lu, Mengjia Weng, Yiru Wang, Jun Tang, Qian Xu, Lei Zhang, Jiaojiao Bai. Promoting tissue repair using deferoxamine nanoparticles loaded biomimetic gelatin/HA composite hydrogel.
Biomedical materials (Bristol, England).
2024 May; 19(4):. doi:
10.1088/1748-605x/ad46ba. [PMID: 38697149] - S Nithyapriya, Lalitha Sundaram, Sakthi Uma Devi Eswaran, Kahkashan Perveen, Najla A Alshaikh, R Z Sayyed, Andrea Mastinu. Purification and Characterization of Desferrioxamine B of Pseudomonas fluorescens and Its Application to Improve Oil Content, Nutrient Uptake, and Plant Growth in Peanuts.
Microbial ecology.
2024 Apr; 87(1):60. doi:
10.1007/s00248-024-02377-0. [PMID: 38630182] - Pei-Heng Lu, Peng-Wei Ma, Wei-Long Wang, Wei Gao, Jia-Wei Chen, Hao Yuan, Xue-Rui Ding, Yu-Qiang Lun, Rui Liang, Si-Yu Li, Zi Wang, Jia-Ning Guo, Hong-Kai Mei, Lian-Jun Lu. Deferoxamine protects cochlear hair cells and hair cell-like HEI-OC1 cells against tert-butyl hydroperoxide-induced ototoxicity.
Biochimica et biophysica acta. Molecular basis of disease.
2024 Jan; 1870(3):167024. doi:
10.1016/j.bbadis.2024.167024. [PMID: 38242180] - Yidan Liang, Yanglingxi Wang, Chao Sun, Yi Xiang, Yongbing Deng. Deferoxamine reduces endothelial ferroptosis and protects cerebrovascular function after experimental traumatic brain injury.
Brain research bulletin.
2024 Jan; 207(?):110878. doi:
10.1016/j.brainresbull.2024.110878. [PMID: 38218407] - Mahdi Aalikhani, Ensie Taheri, Masoumeh Khalili. Vanillin serves as a potential substitute for chemical chelator desferal in iron-overloaded mice.
European journal of pharmacology.
2023 Dec; 960(?):176153. doi:
10.1016/j.ejphar.2023.176153. [PMID: 38059446] - Caihong Wu, Wenxin Zhang, Feifei Yan, Wenwen Dai, Fang Fang, Yanli Gao, Weiwei Cui. Amelioration effects of the soybean lecithin-gallic acid complex on iron-overload-induced oxidative stress and liver damage in C57BL/6J mice.
Pharmaceutical biology.
2023 Dec; 61(1):37-49. doi:
10.1080/13880209.2022.2151632. [PMID: 36573499] - Vasko Gerzilov, Madlena Andreeva, Elina Tsvetanova, Almira Georgieva, Albena Alexandrova. Improvement of diluted semen from Muscovy (Cairina moschata) drakes by the addition of water-soluble antioxidants.
Reproduction in domestic animals = Zuchthygiene.
2023 Oct; ?(?):. doi:
10.1111/rda.14487. [PMID: 37818658] - X Zhang, Z Wu, H Lan, S Chen, J Wu, L Zhu, Y Xiao. [Deferoxamine promotes recovery of bone marrow hematopoietic function in mice exposed to a sublethal dose of X-ray irradiation].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2023 Sep; 43(9):1577-1584. doi:
10.12122/j.issn.1673-4254.2023.09.15. [PMID: 37814872] - Haoran Jia, Xilei Liu, Yiyao Cao, Hanhong Niu, LanZhang, RuiJun Li, Fanjian Li, Dongdong Sun, Mingming Shi, Liang Wa, Xiao Liu, Guili Yang, Fanglian Chen, Shu Zhang, Jianning Zhang. Deferoxamine ameliorates neurological dysfunction by inhibiting ferroptosis and neuroinflammation after traumatic brain injury.
Brain research.
2023 May; ?(?):148383. doi:
10.1016/j.brainres.2023.148383. [PMID: 37149247] - Silvia Ghislanzoni, Gaia Martina Sarcinelli, Arianna Bresci, Francesco Manetti, Dario Polli, Antonella Tomassetti, Maria Teresa Radice, Italia Bongarzone. Reduced sulfatide content in deferoxamine-induced senescent HepG2 cells.
The international journal of biochemistry & cell biology.
2023 Apr; 159(?):106419. doi:
10.1016/j.biocel.2023.106419. [PMID: 37086817] - Yong-Il Cheon, Ji Min Kim, Sung-Chan Shin, Hyung-Sik Kim, Jin-Choon Lee, Gi Cheol Park, Eui-Suk Sung, Minhyung Lee, Byung-Joo Lee. Effect of deferoxamine and ferrostatin-1 on salivary gland dysfunction in ovariectomized rats.
Aging.
2023 04; 15(7):2418-2432. doi:
10.18632/aging.204641. [PMID: 37036468] - Sandra Díez-Villares, Lara García-Varela, Soraya Groba-de Antas, José Ramón Caeiro, Paula Carpintero-Fernandez, María D Mayán, Pablo Aguiar, María de la Fuente. Quantitative PET tracking of intra-articularly administered 89Zr-peptide-decorated nanoemulsions.
Journal of controlled release : official journal of the Controlled Release Society.
2023 04; 356(?):702-713. doi:
10.1016/j.jconrel.2023.03.025. [PMID: 36931471] - Shiyu Chen, Fangfang Fan, Yingrui Zhang, Jiuseng Zeng, Yuxuan Li, Ning Xu, Yi Zhang, Xian-Li Meng, Jin-Ming Lin. Metabolites from scutellarin alleviating deferoxamine-induced hypoxia injury in BV2 cells cultured on microfluidic chip combined with a mass spectrometer.
Talanta.
2023 Mar; 259(?):124478. doi:
10.1016/j.talanta.2023.124478. [PMID: 36989966] - Xiuli Liu, Guilan Li, Shaoxiong Chen, Huiyun Jin, Xiaodong Liu, Linfang Zhang, Zhaohui Zhang. Hydrogen sulfide alleviates beryllium sulfate-induced ferroptosis and ferritinophagy in 16HBE cells.
Journal of applied toxicology : JAT.
2023 Feb; ?(?):. doi:
10.1002/jat.4453. [PMID: 36843388] - Yufei Chen, Xueting Li, Siyuan Wang, Ran Miao, Jiuchang Zhong. Targeting Iron Metabolism and Ferroptosis as Novel Therapeutic Approaches in Cardiovascular Diseases.
Nutrients.
2023 Jan; 15(3):. doi:
10.3390/nu15030591. [PMID: 36771298] - Zengxin Jiang, Hao Wang, Guobin Qi, Chang Jiang, Kangning Chen, Zuoqin Yan. Iron overload-induced ferroptosis of osteoblasts inhibits osteogenesis and promotes osteoporosis: An in vitro and in vivo study.
IUBMB life.
2022 11; 74(11):1052-1069. doi:
10.1002/iub.2656. [PMID: 35638167] - Borong Zhou, Zhongchao Mai, Ying Ye, Yanan Song, Miao Zhang, Xinlin Yang, Wei Xia, Xiaofeng Qiu. The role of PYCR1 in inhibiting 5-fluorouracil-induced ferroptosis and apoptosis through SLC25A10 in colorectal cancer.
Human cell.
2022 Nov; 35(6):1900-1911. doi:
10.1007/s13577-022-00775-5. [PMID: 36104652] - Yuehong Shen, Xinyu Shen, Shulin Wang, Yunyun Zhang, Yue Wang, Ye Ding, Jiayun Shen, Jianqiao Zhao, Huahan Qin, Yijiao Xu, Qian Zhou, Xindong Wang, Jianping Shen. Protective effects of Salvianolic acid B on rat ferroptosis in myocardial infarction through upregulating the Nrf2 signaling pathway.
International immunopharmacology.
2022 Nov; 112(?):109257. doi:
10.1016/j.intimp.2022.109257. [PMID: 36174419] - Zhaoqi He, Peng Shen, Lianjun Feng, Haoyang Hao, Yuhong He, Guyue Fan, Zhuoyu Liu, Kun Zhu, Yiqi Wang, Naisheng Zhang, Xiaoyu Hu, Yunhe Fu, Jiacheng Wu. Cadmium induces liver dysfunction and ferroptosis through the endoplasmic stress-ferritinophagy axis.
Ecotoxicology and environmental safety.
2022 Oct; 245(?):114123. doi:
10.1016/j.ecoenv.2022.114123. [PMID: 36183427] - Wenya Feng, Yuanjing Xiao, Chuanfang Zhao, Zhanming Zhang, Wei Liu, Juan Ma, Tomas Ganz, Junliang Zhang, Sijin Liu. New Deferric Amine Compounds Efficiently Chelate Excess Iron to Treat Iron Overload Disorders and to Prevent Ferroptosis.
Advanced science (Weinheim, Baden-Wurttemberg, Germany).
2022 10; 9(29):e2202679. doi:
10.1002/advs.202202679. [PMID: 36031399] - Wei-Liang Kong, Tong-Yue Wen, Ya-Hui Wang, Xiao-Qin Wu. Physiological and Transcriptome Analyses Revealed the Mechanism by Which Deferoxamine Promotes Iron Absorption in Cinnamomum camphora.
International journal of molecular sciences.
2022 Aug; 23(17):. doi:
10.3390/ijms23179854. [PMID: 36077250] - Rongli Sun, Manman Liu, Kai Xu, Yunqiu Pu, Jiawei Huang, Jinyan Liu, Juan Zhang, Lihong Yin, Yuepu Pu. Ferroptosis is involved in the benzene-induced hematotoxicity in mice via iron metabolism, oxidative stress and NRF2 signaling pathway.
Chemico-biological interactions.
2022 Aug; 362(?):110004. doi:
10.1016/j.cbi.2022.110004. [PMID: 35661779] - Elisa Borella, Sean Oosterholt, Paolo Magni, Oscar Della Pasqua. Characterisation of individual ferritin response in patients receiving chelation therapy.
British journal of clinical pharmacology.
2022 Aug; 88(8):3683-3694. doi:
10.1111/bcp.15290. [PMID: 35199367] - V A Aneesha, Asif Qayoom, S Anagha, Shah Ayub Almas, V K Naresh, Sanjay Kumawat, W Ramdas Singh, Abdul Sadam, M Dinesh, T S Shyamkumar, Monalisa Sahoo, Madhu C Lingaraju, Thakur Uttam Singh, Dinesh Kumar. Topical bilirubin-deferoxamine hastens excisional wound healing by modulating inflammation, oxidative stress, angiogenesis, and collagen deposition in diabetic rats.
Journal of tissue viability.
2022 Aug; 31(3):474-484. doi:
10.1016/j.jtv.2022.04.009. [PMID: 35595596] - Xing Peng, Qingyun Tan, Leiming Wu, Deyin Wu, Jun Xu, Huihao Zhou, Qiong Gu. Ferroptosis Inhibitory Aromatic Abietane Diterpenoids from Ajuga decumbens and Structural Revision of Two 3,4-Epoxy Group-Containing Abietanes.
Journal of natural products.
2022 07; 85(7):1808-1815. doi:
10.1021/acs.jnatprod.2c00352. [PMID: 35796002] - Zhexin Ni, Yangshuo Li, Di Song, Jie Ding, Shanshan Mei, Shuai Sun, Wen Cheng, Jin Yu, Ling Zhou, Yanping Kuang, Mingqing Li, Zailong Cai, Chaoqin Yu. Iron-overloaded follicular fluid increases the risk of endometriosis-related infertility by triggering granulosa cell ferroptosis and oocyte dysmaturity.
Cell death & disease.
2022 07; 13(7):579. doi:
10.1038/s41419-022-05037-8. [PMID: 35787614] - Sen Lin, Wa Gao, Chenchen Zhu, Qi Lou, Cong Ye, Yueping Ren, Rashid Mehmood, Baoshan Huang, Kaihui Nan. Efficiently suppress of ferroptosis using deferoxamine nanoparticles as a new method for retinal ganglion cell protection after traumatic optic neuropathy.
Biomaterials advances.
2022 Jul; 138(?):212936. doi:
10.1016/j.bioadv.2022.212936. [PMID: 35913229] - Olamide B Adelusi, Anup Ramachandran, John J Lemasters, Hartmut Jaeschke. The role of Iron in lipid peroxidation and protein nitration during acetaminophen-induced liver injury in mice.
Toxicology and applied pharmacology.
2022 06; 445(?):116043. doi:
10.1016/j.taap.2022.116043. [PMID: 35513057] - Pavlína Hašková, Lenka Applová, Hana Jansová, Pavel Homola, Katherine J Franz, Kateřina Vávrová, Jaroslav Roh, Tomáš Šimůnek. Examination of diverse iron-chelating agents for the protection of differentiated PC12 cells against oxidative injury induced by 6-hydroxydopamine and dopamine.
Scientific reports.
2022 06; 12(1):9765. doi:
10.1038/s41598-022-13554-x. [PMID: 35697900] - Ahmad Zargari, Simon Wu, Anthea Greenway, Ken Cheng, Zane Kaplan. Effects of dual chelation therapy with deferasirox and deferoxamine in patients with beta thalassaemia major.
Vox sanguinis.
2022 May; 117(5):733-737. doi:
10.1111/vox.13248. [PMID: 35014065] - Laurin Müller, Denise C Müller, Sandrine Kammerecker, Marco Fluri, Lukas Neutsch, Mitja Remus Emsermann, Cosima Pelludat. Priority Effects in the Apple Flower Determine If the Siderophore Desferrioxamine Is a Virulence Factor for Erwinia amylovora CFBP1430.
Applied and environmental microbiology.
2022 04; 88(7):e0243321. doi:
10.1128/aem.02433-21. [PMID: 35285239] - Janet L Kwiatkowski, Mona Hamdy, Amal El-Beshlawy, Fatma S E Ebeid, Mohammed Badr, Abdulrahman Alshehri, Julie Kanter, Baba Inusa, Amira A M Adly, Suzan Williams, Yurdanur Kilinc, David Lee, Fernando Tricta, Mohsen S Elalfy. Deferiprone vs deferoxamine for transfusional iron overload in SCD and other anemias: a randomized, open-label noninferiority study.
Blood advances.
2022 02; 6(4):1243-1254. doi:
10.1182/bloodadvances.2021004938. [PMID: 34847228] - Rachel P L van Swelm, Sanne Beurskens, Henry Dijkman, Erwin T G Wiegerinck, Rian Roelofs, Frank Thévenod, Johan van der Vlag, Jack F M Wetzels, Dorine W Swinkels, Bart Smeets. Kidney tubule iron loading in experimental focal segmental glomerulosclerosis.
Scientific reports.
2022 01; 12(1):1199. doi:
10.1038/s41598-022-05261-4. [PMID: 35075227] - Yu Cao, Hong Zhang, Jianming Tang, Rui Wang. Ferulic Acid Mitigates Growth and Invasion of Esophageal Squamous Cell Carcinoma through Inducing Ferroptotic Cell Death.
Disease markers.
2022; 2022(?):4607966. doi:
10.1155/2022/4607966. [PMID: 36267458] - Ola E Nafea, Marwa Zakaria, Tamer Hassan, Sherif M El Gebaly, Hosam E Salah. Subclinical nephrotoxicity in patients with beta-thalassemia: role of urinary kidney injury molecule.
Drug and chemical toxicology.
2022 Jan; 45(1):93-102. doi:
10.1080/01480545.2019.1660362. [PMID: 31905029] - Yi Lyu, Xue-Ke Ren, Can-Can Guo, Zhao-Fei Li, Jin-Ping Zheng. Benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide induces ferroptosis in neuroblastoma cells through redox imbalance.
The Journal of toxicological sciences.
2022; 47(12):519-529. doi:
10.2131/jts.47.519. [PMID: 36450496] - Osama Tanous, Yossi Azulay, Raphael Halevy, Tal Dujovny, Neta Swartz, Raul Colodner, Ariel Koren, Carina Levin. Renal function in β-thalassemia major patients treated with two different iron-chelation regimes.
BMC nephrology.
2021 12; 22(1):418. doi:
10.1186/s12882-021-02630-5. [PMID: 34930156] - Shohra Qaderi, Sayed Hamid Mousavi, Attaullah Ahmadi, Shamim Arif, Shekiba Madadi, Sohrab Ayoubi, Don Eliseo Lucero-Prisno. Transfusion-dependent beta thalassemia in Afghanistan: current evidence amid COVID-19 and future recommendations.
Hematology (Amsterdam, Netherlands).
2021 Dec; 26(1):432-434. doi:
10.1080/16078454.2021.1938814. [PMID: 34130618] - Dingxi Li, Mengli Zhang, Hongtu Chao. Significance of glutathione peroxidase 4 and intracellular iron level in ovarian cancer cells-'utilization' of ferroptosis mechanism.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2021 Dec; 70(10-12):1177-1189. doi:
10.1007/s00011-021-01495-6. [PMID: 34537856] - Haipeng Cheng, Dandan Feng, Xiaohong Li, Lihua Gao, Siyuan Tang, Wei Liu, Xiaoying Wu, Shaojie Yue, Chen Li, Ziqiang Luo. Iron deposition-induced ferroptosis in alveolar type II cells promotes the development of pulmonary fibrosis.
Biochimica et biophysica acta. Molecular basis of disease.
2021 12; 1867(12):166204. doi:
10.1016/j.bbadis.2021.166204. [PMID: 34175430] - Ali Cm Johnson, Richard A Zager. Catalytic iron mediated renal stress responses during experimental cardiorenal syndrome 1 ("CRS-1").
Translational research : the journal of laboratory and clinical medicine.
2021 11; 237(?):53-62. doi:
10.1016/j.trsl.2021.06.005. [PMID: 34217897] - Bingquan Jian, Jiaqi Pang, Hao Xiong, Weijian Zhang, Ting Zhan, Zhongwu Su, Hanqing Lin, Huasong Zhang, Wuhui He, Yiqing Zheng. Autophagy-dependent ferroptosis contributes to cisplatin-induced hearing loss.
Toxicology letters.
2021 Oct; 350(?):249-260. doi:
10.1016/j.toxlet.2021.07.010. [PMID: 34302894] - Jinghan Li, Simeng Wang, Jiaqi Duan, Peixin Le, Chao Li, Yongpei Ding, Rui Wang, Yonggang Gao. The protective mechanism of resveratrol against hepatic injury induced by iron overload in mice.
Toxicology and applied pharmacology.
2021 08; 424(?):115596. doi:
10.1016/j.taap.2021.115596. [PMID: 34044072] - Stephanie Probst, Johannes Fels, Bettina Scharner, Natascha A Wolff, Eleni Roussa, Rachel P L van Swelm, Wing-Kee Lee, Frank Thévenod. Role of hepcidin in oxidative stress and cell death of cultured mouse renal collecting duct cells: protection against iron and sensitization to cadmium.
Archives of toxicology.
2021 08; 95(8):2719-2735. doi:
10.1007/s00204-021-03106-z. [PMID: 34181029] - Olga P Ajsuvakova, Margarita G Skalnaya, Bernhard Michalke, Alexey A Tinkov, Eugeny P Serebryansky, Mikhail Yu Karganov, Yulia S Medvedeva, Anatoly V Skalny. Alteration of iron (Fe), copper (Cu), zinc (Zn), and manganese (Mn) tissue levels and speciation in rats with desferioxamine-induced iron deficiency.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine.
2021 08; 34(4):923-936. doi:
10.1007/s10534-021-00318-9. [PMID: 34003408] - Yasir Abdul, Weiguo Li, Rebecca Ward, Mohammed Abdelsaid, Sherif Hafez, Guangkuo Dong, Sarah Jamil, Victoria Wolf, Maribeth H Johnson, Susan C Fagan, Adviye Ergul. Deferoxamine Treatment Prevents Post-Stroke Vasoregression and Neurovascular Unit Remodeling Leading to Improved Functional Outcomes in Type 2 Male Diabetic Rats: Role of Endothelial Ferroptosis.
Translational stroke research.
2021 08; 12(4):615-630. doi:
10.1007/s12975-020-00844-7. [PMID: 32875455] - Amaury Guillou, Daniel F Earley, Simon Klingler, Eda Nisli, Laura J Nüesch, Rachael Fay, Jason P Holland. The Influence of a Polyethylene Glycol Linker on the Metabolism and Pharmacokinetics of a 89Zr-Radiolabeled Antibody.
Bioconjugate chemistry.
2021 07; 32(7):1263-1275. doi:
10.1021/acs.bioconjchem.1c00172. [PMID: 34056896] - Mohamed Belmouhand, Christina Eckmann-Hansen, Tomas Ilginis, Eva Birgitte Leinøe, Bo Kok Mortensen, Michael Larsen. Iron overload and iron chelating agent exposure in anemia-associated outer retinal degeneration: a case report and review of the literature.
BMC ophthalmology.
2021 Jul; 21(1):277. doi:
10.1186/s12886-021-02030-1. [PMID: 34256738] - Dhiman Maitra, Benjamin M Pinsky, Amenah Soherawardy, Haiyan Zheng, Ruma Banerjee, M Bishr Omary. Protein-aggregating ability of different protoporphyrin-IX nanostructures is dependent on their oxidation and protein-binding capacity.
The Journal of biological chemistry.
2021 07; 297(1):100778. doi:
10.1016/j.jbc.2021.100778. [PMID: 34023387] - Denise Bellotti, Maurizio Remelli. Deferoxamine B: A Natural, Excellent and Versatile Metal Chelator.
Molecules (Basel, Switzerland).
2021 May; 26(11):. doi:
10.3390/molecules26113255. [PMID: 34071479] - Valeria M Nurchi, Rosita Cappai, Nadia Spano, Gavino Sanna. A Friendly Complexing Agent for Spectrophotometric Determination of Total Iron.
Molecules (Basel, Switzerland).
2021 May; 26(11):. doi:
10.3390/molecules26113071. [PMID: 34063849] - Hua Tu, Yuan-Jing Zhou, Li-Jing Tang, Xiao-Ming Xiong, Xiao-Jie Zhang, Md Sayed Ali Sheikh, Jie-Jie Zhang, Xiu-Ju Luo, Chuang Yuan, Jun Peng. Combination of ponatinib with deferoxamine synergistically mitigates ischemic heart injury via simultaneous prevention of necroptosis and ferroptosis.
European journal of pharmacology.
2021 May; 898(?):173999. doi:
10.1016/j.ejphar.2021.173999. [PMID: 33675785] - Run-Ze Yang, Wen-Ning Xu, Huo-Liang Zheng, Xin-Feng Zheng, Bo Li, Lei-Sheng Jiang, Sheng-Dan Jiang. Involvement of oxidative stress-induced annulus fibrosus cell and nucleus pulposus cell ferroptosis in intervertebral disc degeneration pathogenesis.
Journal of cellular physiology.
2021 04; 236(4):2725-2739. doi:
10.1002/jcp.30039. [PMID: 32892384] - Marion Chomet, Maxime Schreurs, Maria J Bolijn, Mariska Verlaan, Wissam Beaino, Kari Brown, Alex J Poot, Albert D Windhorst, Herman Gill, Jan Marik, Simon Williams, Joseph Cowell, Gilles Gasser, Thomas L Mindt, Guus A M S van Dongen, Danielle J Vugts. Head-to-head comparison of DFO* and DFO chelators: selection of the best candidate for clinical 89Zr-immuno-PET.
European journal of nuclear medicine and molecular imaging.
2021 03; 48(3):694-707. doi:
10.1007/s00259-020-05002-7. [PMID: 32889615] - Camille Link, Julia D Knopf, Oriana Marques, Marius K Lemberg, Martina U Muckenthaler. The role of cellular iron deficiency in controlling iron export.
Biochimica et biophysica acta. General subjects.
2021 03; 1865(3):129829. doi:
10.1016/j.bbagen.2020.129829. [PMID: 33340587] - Vassilios D Vlahakos, Katerina P Marathias, Nikolaos Arkadopoulos, Demetrios V Vlahakos. Hyperferritinemia in patients with COVID-19: An opportunity for iron chelation?.
Artificial organs.
2021 Feb; 45(2):163-167. doi:
10.1111/aor.13812. [PMID: 32882061] - Zhi Liu, Gregory A Simchick, Jing Qiao, Morgan M Ashcraft, Shuolin Cui, Tamas Nagy, Qun Zhao, May P Xiong. Reactive Oxygen Species-Triggered Dissociation of a Polyrotaxane-Based Nanochelator for Enhanced Clearance of Systemic and Hepatic Iron.
ACS nano.
2021 01; 15(1):419-433. doi:
10.1021/acsnano.0c01083. [PMID: 33378155] - Anis Abobaker. Can iron chelation as an adjunct treatment of COVID-19 improve the clinical outcome?.
European journal of clinical pharmacology.
2020 Nov; 76(11):1619-1620. doi:
10.1007/s00228-020-02942-9. [PMID: 32607779] - Yuan Zhong, Fei Tian, Huanxin Ma, Huihan Wang, Wei Yang, Zhuogang Liu, Aijun Liao. FTY720 induces ferroptosis and autophagy via PP2A/AMPK pathway in multiple myeloma cells.
Life sciences.
2020 Nov; 260(?):118077. doi:
10.1016/j.lfs.2020.118077. [PMID: 32810509] - Xi Chen, Dan Li, Hai-Ying Sun, Wen-Wen Wang, Han Wu, Wen Kong, Wei-Jia Kong. Relieving ferroptosis may partially reverse neurodegeneration of the auditory cortex.
The FEBS journal.
2020 11; 287(21):4747-4766. doi:
10.1111/febs.15266. [PMID: 32112499] - Kyu Min Kim, Sam Seok Cho, Sung Hwan Ki. Emerging roles of ferroptosis in liver pathophysiology.
Archives of pharmacal research.
2020 Oct; 43(10):985-996. doi:
10.1007/s12272-020-01273-8. [PMID: 33079307] - Alireza Gazeri, Azadeh Aminzadeh. Protective effects of deferoxamine on lead-induced cardiotoxicity in rats.
Toxicology and industrial health.
2020 Oct; 36(10):800-806. doi:
10.1177/0748233720947231. [PMID: 32812511] - Emanuel Peplau, Francesco De Rose, Sybille Reder, Markus Mittelhäuser, Giorgia Scafetta, Markus Schwaiger, Wolfgang A Weber, Armando Bartolazzi, Arne Skerra, Calogero D'Alessandria. Development of a Chimeric Antigen-Binding Fragment Directed Against Human Galectin-3 and Validation as an Immuno-Positron Emission Tomography Tracer for the Sensitive In Vivo Imaging of Thyroid Cancer.
Thyroid : official journal of the American Thyroid Association.
2020 09; 30(9):1314-1326. doi:
10.1089/thy.2019.0670. [PMID: 32200708] - Hao Zheng, Jieyun You, Xiaobo Yao, Qizheng Lu, Wei Guo, Yunli Shen. Superparamagnetic iron oxide nanoparticles promote ferroptosis of ischemic cardiomyocytes.
Journal of cellular and molecular medicine.
2020 09; 24(18):11030-11033. doi:
10.1111/jcmm.15722. [PMID: 32780538] - Guoqing Tang, Yong Chen, Ji Chen, Zhe Chen, Weimin Jiang. Deferoxamine Ameliorates Compressed Spinal Cord Injury by Promoting Neovascularization in Rats.
Journal of molecular neuroscience : MN.
2020 Sep; 70(9):1437-1444. doi:
10.1007/s12031-020-01564-1. [PMID: 32383023] - Elaheh Khozeimeh Sarbisheh, Akam K Salih, Shvan J Raheem, Jason S Lewis, Eric W Price. A High-Denticity Chelator Based on Desferrioxamine for Enhanced Coordination of Zirconium-89.
Inorganic chemistry.
2020 Aug; 59(16):11715-11727. doi:
10.1021/acs.inorgchem.0c01629. [PMID: 32799484] - Simon Klingler, Rachael Fay, Jason P Holland. Light-Induced Radiosynthesis of 89Zr-DFO-Azepin-Onartuzumab for Imaging the Hepatocyte Growth Factor Receptor.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2020 07; 61(7):1072-1078. doi:
10.2967/jnumed.119.237180. [PMID: 31924725] - Hyungjun Cho, Noor Al-Saden, Heather Lam, Juri Möbus, Raymond M Reilly, Mitchell A Winnik. A comparison of DFO and DFO* conjugated to trastuzumab-DM1 for complexing 89Zr - In vitro stability and in vivo microPET/CT imaging studies in NOD/SCID mice with HER2-positive SK-OV-3 human ovarian cancer xenografts.
Nuclear medicine and biology.
2020 May; 84-85(?):11-19. doi:
10.1016/j.nucmedbio.2019.12.009. [PMID: 31931305] - Steven A Bloomer, Kyle E Brown, Kevin C Kregel. Renal Iron Accumulation and Oxidative Injury With Aging: Effects of Treatment With an Iron Chelator.
The journals of gerontology. Series A, Biological sciences and medical sciences.
2020 03; 75(4):680-684. doi:
10.1093/gerona/glz055. [PMID: 30794723] - Kazuhiko Higashida, Nodoka Takeuchi, Sachika Inoue, Takeshi Hashimoto, Naoya Nakai. Iron deficiency attenuates catecholamine‑stimulated lipolysis via downregulation of lipolysis‑related proteins and glucose utilization in 3T3‑L1 adipocytes.
Molecular medicine reports.
2020 03; 21(3):1383-1389. doi:
10.3892/mmr.2020.10929. [PMID: 32016466] - Cristiane Ritter, Larissa Constantino, Monique Michels, Renata Casagrande Gonçalves, Cassiana Fraga, Danusa Damásio, Felipe Dal-Pizzol. Stratification to predict the response to antioxidant.
Revista Brasileira de terapia intensiva.
2020 Mar; 32(1):108-114. doi:
10.5935/0103-507x.20200016. [PMID: 32401970] - Ariunaa Sampilvanjil, Tadayoshi Karasawa, Naoya Yamada, Takanori Komada, Tsunehito Higashi, Chintogtokh Baatarjav, Sachiko Watanabe, Ryo Kamata, Nobuhiko Ohno, Masafumi Takahashi. Cigarette smoke extract induces ferroptosis in vascular smooth muscle cells.
American journal of physiology. Heart and circulatory physiology.
2020 03; 318(3):H508-H518. doi:
10.1152/ajpheart.00559.2019. [PMID: 31975626] - Susan Becker. Comparing Care of the Primary and Secondary Hemochromatosis Patients.
Journal of infusion nursing : the official publication of the Infusion Nurses Society.
2020 Mar; 43(2):65-69. doi:
10.1097/nan.0000000000000358. [PMID: 32106193] - Naoya Yamada, Tadayoshi Karasawa, Hiroaki Kimura, Sachiko Watanabe, Takanori Komada, Ryo Kamata, Ariunaa Sampilvanjil, Junya Ito, Kiyotaka Nakagawa, Hiroshi Kuwata, Shuntaro Hara, Koichi Mizuta, Yasunaru Sakuma, Naohiro Sata, Masafumi Takahashi. Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure.
Cell death & disease.
2020 02; 11(2):144. doi:
10.1038/s41419-020-2334-2. [PMID: 32094346] - Leah Mursaleen, Satyanarayana Somavarapu, Mohammed Gulrez Zariwala. Deferoxamine and Curcumin Loaded Nanocarriers Protect Against Rotenone-Induced Neurotoxicity.
Journal of Parkinson's disease.
2020; 10(1):99-111. doi:
10.3233/jpd-191754. [PMID: 31868679] - James M Kidd, Kamilia Abdelraouf, David P Nicolau. Development of Neutropenic Murine Models of Iron Overload and Depletion To Study the Efficacy of Siderophore-Antibiotic Conjugates.
Antimicrobial agents and chemotherapy.
2019 12; 64(1):. doi:
10.1128/aac.01961-19. [PMID: 31658967] - Shadab Faham, Hamed Golmohammadi, Raouf Ghavami, Gholamreza Khayatian. A nanocellulose-based colorimetric assay kit for smartphone sensing of iron and iron-chelating deferoxamine drug in biofluids.
Analytica chimica acta.
2019 Dec; 1087(?):104-112. doi:
10.1016/j.aca.2019.08.056. [PMID: 31585557] - Jacob Kosyakovsky, Bruce A Witthuhn, Aleta L Svitak, William H Frey, Leah R Hanson, Jared M Fine. Quantifying Intranasally Administered Deferoxamine in Rat Brain Tissue with Mass Spectrometry.
ACS chemical neuroscience.
2019 11; 10(11):4571-4578. doi:
10.1021/acschemneuro.9b00436. [PMID: 31573798] - Ruizhu Liu, Xuefeng Li, Guoqing Zhao. Beclin1-mediated ferroptosis activation is associated with isoflurane-induced toxicity in SH-SY5Y neuroblastoma cells.
Acta biochimica et biophysica Sinica.
2019 Nov; 51(11):1134-1141. doi:
10.1093/abbs/gmz104. [PMID: 31650158] - Homan Kang, Murui Han, Jie Xue, Yoonji Baek, JuOae Chang, Shuang Hu, HaYoung Nam, Min Joo Jo, Georges El Fakhri, Michael P Hutchens, Hak Soo Choi, Jonghan Kim. Renal clearable nanochelators for iron overload therapy.
Nature communications.
2019 11; 10(1):5134. doi:
10.1038/s41467-019-13143-z. [PMID: 31723130] - Yan Wang, Meng Tang. PM2.5 induces ferroptosis in human endothelial cells through iron overload and redox imbalance.
Environmental pollution (Barking, Essex : 1987).
2019 Nov; 254(Pt A):112937. doi:
10.1016/j.envpol.2019.07.105. [PMID: 31401526] - Aziz Eghbali, Atefeh Khalilpour, Hassan Taherahmadi, Bahador Bagheri. Pantoprazole reduces serum ferritin in patients with thalassemia major and intermedia: A randomized, controlled study.
Therapie.
2019 Oct; 74(5):507-512. doi:
10.1016/j.therap.2018.11.013. [PMID: 30704764] - Jian Zhang, Wentao Hu, Chong Ding, Gang Yao, Hai Zhao, Shuguang Wu. Deferoxamine inhibits iron-uptake stimulated osteoclast differentiation by suppressing electron transport chain and MAPKs signaling.
Toxicology letters.
2019 Oct; 313(?):50-59. doi:
10.1016/j.toxlet.2019.06.007. [PMID: 31238089] - Su Jung Park, Sam Seok Cho, Kyu Min Kim, Ji Hye Yang, Jae Hoon Kim, Eun Hee Jeong, Jin Won Yang, Chang Yeob Han, Sae Kwang Ku, Il Je Cho, Sung Hwan Ki. Protective effect of sestrin2 against iron overload and ferroptosis-induced liver injury.
Toxicology and applied pharmacology.
2019 09; 379(?):114665. doi:
10.1016/j.taap.2019.114665. [PMID: 31323261] - Kosuke Dodo, Erika Kuboki, Tadashi Shimizu, Ryu Imamura, Megumi Magarisawa, Masahiro Takahashi, Takuto Tokuhiro, Satoshi Yotsumoto, Kenichi Asano, Shuhei Nakao, Naoki Terayama, Takashi Suda, Masato Tanaka, Mikiko Sodeoka. Development of a Water-Soluble Indolylmaleimide Derivative IM-93 Showing Dual Inhibition of Ferroptosis and NETosis.
ACS medicinal chemistry letters.
2019 Sep; 10(9):1272-1278. doi:
10.1021/acsmedchemlett.9b00142. [PMID: 31531196] - Ilias Georgalas, Georgios Makris, Dimitrios Papaconstantinou, Petros Petrou, Evangelia Chalkiadaki, Konstantinos Droutsas, Konstantinos Andreanos, Menelaos Kanakis. A Pilot Optical Coherence Tomography Angiography Study on Superficial and Deep Capillary Plexus Foveal Avascular Zone in Patients With Beta-Thalassemia Major.
Investigative ophthalmology & visual science.
2019 09; 60(12):3887-3896. doi:
10.1167/iovs.19-27291. [PMID: 31529120] - Ho Man Tang, Peter Chi Keung Cheung. Gallic Acid Triggers Iron-Dependent Cell Death with Apoptotic, Ferroptotic, and Necroptotic Features.
Toxins.
2019 08; 11(9):. doi:
10.3390/toxins11090492. [PMID: 31455047] - René Raavé, Gerwin Sandker, Pierre Adumeau, Christian Borch Jacobsen, Floriane Mangin, Michel Meyer, Mathieu Moreau, Claire Bernhard, Laurène Da Costa, Adrien Dubois, Victor Goncalves, Magnus Gustafsson, Mark Rijpkema, Otto Boerman, Jean-Claude Chambron, Sandra Heskamp, Franck Denat. Direct comparison of the in vitro and in vivo stability of DFO, DFO* and DFOcyclo* for 89Zr-immunoPET.
European journal of nuclear medicine and molecular imaging.
2019 Aug; 46(9):1966-1977. doi:
10.1007/s00259-019-04343-2. [PMID: 31161258] - Sarah R Verhoeff, Suzanne C van Es, Eline Boon, Erik van Helden, Lindsay Angus, Sjoerd G Elias, Sjoukje F Oosting, Erik H Aarntzen, Adrienne H Brouwers, Thomas C Kwee, Sandra Heskamp, Otto S Hoekstra, Henk Verheul, Astrid A M van der Veldt, Elisabeth G E de Vries, Otto C Boerman, Winette T A van der Graaf, Wim J G Oyen, Carla M L van Herpen. Lesion detection by [89Zr]Zr-DFO-girentuximab and [18F]FDG-PET/CT in patients with newly diagnosed metastatic renal cell carcinoma.
European journal of nuclear medicine and molecular imaging.
2019 Aug; 46(9):1931-1939. doi:
10.1007/s00259-019-04358-9. [PMID: 31172212] - Joanna Mucha, Elżbieta Gabała, Marcin Zadworny. The effects of structurally different siderophores on the organelles of Pinus sylvestris root cells.
Planta.
2019 Jun; 249(6):1747-1760. doi:
10.1007/s00425-019-03117-2. [PMID: 30820648] - Elizabeth G Bromfield, Jessica L H Walters, Shenae L Cafe, Ilana R Bernstein, Simone J Stanger, Amanda L Anderson, R John Aitken, Eileen A McLaughlin, Matthew D Dun, Barend M Gadella, Brett Nixon. Differential cell death decisions in the testis: evidence for an exclusive window of ferroptosis in round spermatids.
Molecular human reproduction.
2019 05; 25(5):241-256. doi:
10.1093/molehr/gaz015. [PMID: 30865280] - Vida Nazemian, Somayeh Kalanaky, Homa Manaheji, Etrat Houshmandi, Mola Mohammadi, Jalal Zaringhalam, Somayeh Mirjafai. Anti-hyperalgesia effect of nanchelating based nano particle, RAc1, can be mediated via liver hepcidin expression modulation during persistent inflammation.
International immunopharmacology.
2019 Apr; 69(?):337-346. doi:
10.1016/j.intimp.2019.02.003. [PMID: 30776642] - Chien-Heng Lin, Xianxiu Chen, Chin-Ching Wu, Kang-Hsi Wu, Ta-Shu Song, Te-Fu Weng, Yow-Wen Hsieh, Ching-Tien Peng. Therapeutic mechanism of combined oral chelation therapy to maximize efficacy of iron removal in transfusion-dependent thalassemia major - a pilot study.
Expert review of hematology.
2019 04; 12(4):265-272. doi:
10.1080/17474086.2019.1593823. [PMID: 30920854] - Shreya Pramanik, Saikat Chakraborty, Malavika Sivan, Birija S Patro, Sucheta Chatterjee, Dibakar Goswami. Cell Permeable Imidazole-Desferrioxamine Conjugates: Synthesis and In Vitro Evaluation.
Bioconjugate chemistry.
2019 03; 30(3):841-852. doi:
10.1021/acs.bioconjchem.8b00924. [PMID: 30762349] - Christopher Trent Brewer, Lei Yang, Anne Edwards, Yan Lu, Jonathan Low, Jing Wu, Richard E Lee, Taosheng Chen. The Isoniazid Metabolites Hydrazine and Pyridoxal Isonicotinoyl Hydrazone Modulate Heme Biosynthesis.
Toxicological sciences : an official journal of the Society of Toxicology.
2019 03; 168(1):209-224. doi:
10.1093/toxsci/kfy294. [PMID: 30517741] - Ivan Polsinelli, Luigimaria Borruso, Rosanna Caliandro, Luca Triboli, Alfonso Esposito, Stefano Benini. A genome-wide analysis of desferrioxamine mediated iron uptake in Erwinia spp. reveals genes exclusive of the Rosaceae infecting strains.
Scientific reports.
2019 02; 9(1):2818. doi:
10.1038/s41598-019-39787-x. [PMID: 30808981] - Akira Joraku, Kentaro Hatano, Koji Kawai, Shuya Kandori, Takahiro Kojima, Nobuyoshi Fukumitsu, Tomonori Isobe, Yutaro Mori, Muneyuki Sakata, Tadashi Hara, Katsuhiro Nasu, Manabu Minami, Yuichi Iizumi, Hiroyuki Nishiyama. Phase I/IIa PET imaging study with 89zirconium labeled anti-PSMA minibody for urological malignancies.
Annals of nuclear medicine.
2019 Feb; 33(2):119-127. doi:
10.1007/s12149-018-1312-6. [PMID: 30406361]
