Corticosterone (BioDeep_00000001311)

 

Secondary id: BioDeep_00000405455

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019 natural product


代谢物信息卡片


(1S,2R,10S,11S,14S,15S,17S)-17-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one

化学式: C21H30O4 (346.2144)
中文名称: 皮质酮, 肾上腺酮
谱图信息: 最多检出来源 Homo sapiens(plant) 19.08%

Reviewed

Last reviewed on 2024-07-15.

Cite this Page

Corticosterone. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/corticosterone (retrieved 2024-12-23) (BioDeep RN: BioDeep_00000001311). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1CC2[C@]([C@@]3([H])[C@@H](O)C[C@@]4(C)[C@@]([H])(CC[C@@]4(C(=O)CO)[H])[C@]13[H])(C)CCC(=O)C=2
InChI: InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1

描述信息

Corticosterone, also known as 17-deoxycortisol, belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone. Thus, corticosterone is considered to be a steroid lipid molecule. Corticosterone is a very hydrophobic molecule, practically insoluble in water, and relatively neutral. In many species, including amphibians, reptiles, rodents and birds, corticosterone is a main glucocorticoid,[3] involved in regulation of energy, immune reactions, and stress responses. Corticosterone is the precursor molecule to the mineralocorticoid aldosterone, one of the major homeostatic modulators of sodium and potassium levels in vivo.

Corticosterone. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=50-22-6 (retrieved 2024-07-15) (CAS RN: 50-22-6). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect[1][2][3][4].
Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect[1][2][3][4].
Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect[1][2][3][4].

同义名列表

24 个代谢物同义名

(1S,2R,10S,11S,14S,15S,17S)-17-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one; (11beta)-11,21-dihydroxypregn-4-ene-3,20-dione; (11b)-11,21-Dihydroxypregn-4-ene-3,20-dione; (11Β)-11,21-dihydroxypregn-4-ene-3,20-dione; 11beta,21-dihydroxypregn-4-ene-3,20-dione; 11beta,21-Dihydroxy-4-pregnene-3,20-dione; 11Β,21-dihydroxy-4-pregnene-3,20-dione; 11b,21-Dihydroxy-4-pregnene-3,20-dione; 11,21-Dihydroxypregn-4-ene-3,20-dione; 11beta,21-dihydroxyprogesterone; 11-Hydroxycorticoaldosterone; 11b,21-Dihydroxyprogesterone; 11Β,21-dihydroxyprogesterone; 11,21-Dihydroxyprogesterone; 4-Pregnene-11 corticosteron; Reichsteins substance H; Kendalls compound B; corticosterone-d8; 17-deoxycortisol; Corticosterone; ST 21:3;O4; Corticosterone; Kendall's compound B; Corticosterone



数据库引用编号

45 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(13)

BioCyc(0)

PlantCyc(0)

代谢反应

101 个相关的代谢反应过程信息。

Reactome(63)

BioCyc(0)

WikiPathways(3)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(35)

PharmGKB(0)

15 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 CA2, CAT, DBH, GRIN2B
Peripheral membrane protein 2 ACHE, CYP11B1
Endosome membrane 1 SLC6A4
Endoplasmic reticulum membrane 4 CD4, CYP11B1, GRIN2B, STAR
Mitochondrion membrane 1 SLC22A3
Nucleus 1 ACHE
cytosol 3 CA2, CAT, TAT
dendrite 2 DRD2, HTR1A
mitochondrial membrane 1 SLC22A3
Cell membrane 11 ACHE, ADRB3, CA2, CD4, CD8A, DRD2, GRIN2B, HTR1A, SLC22A3, SLC6A4, STAR
Multi-pass membrane protein 6 ADRB3, DRD2, GRIN2B, HTR1A, SLC22A3, SLC6A4
Golgi apparatus membrane 1 DRD2
Synapse 5 ACHE, DBH, DRD2, HTR1A, SLC6A4
cell surface 2 ACHE, GRIN2B
glutamatergic synapse 1 DRD2
Golgi apparatus 2 ACHE, NPY
Golgi membrane 1 DRD2
mitochondrial inner membrane 1 CYP11B1
neuromuscular junction 1 ACHE
neuronal cell body 1 SLC22A3
presynaptic membrane 2 DRD2, SLC6A4
Lysosome 1 GRIN2B
Presynapse 2 SLC22A3, SLC6A4
acrosomal vesicle 1 DRD2
plasma membrane 12 ACHE, ADRB3, CA2, CD4, CD8A, DRD2, GRIN2B, HTR1A, IFNLR1, SLC22A3, SLC6A4, STAR
synaptic vesicle membrane 1 DRD2
Membrane 7 ACHE, CAT, DBH, GRIN2B, IFNLR1, SLC22A3, SLC6A4
apical plasma membrane 1 SLC22A3
axon 1 DRD2
basolateral plasma membrane 1 SLC22A3
extracellular exosome 2 CA2, CAT
endoplasmic reticulum 1 DBH
extracellular space 5 ACHE, DBH, IGF1, IL2, NPY
perinuclear region of cytoplasm 1 ACHE
mitochondrion 3 CAT, CYP11B1, STAR
protein-containing complex 1 CAT
intracellular membrane-bounded organelle 2 CAT, DBH
postsynaptic density 1 GRIN2B
Single-pass type I membrane protein 4 CD4, CD8A, IFNLR1, STAR
Secreted 6 ACHE, DBH, IGF1, IL2, NPY, TRH
extracellular region 8 ACHE, CAT, CD8A, DBH, IGF1, IL2, NPY, TRH
[Isoform 2]: Secreted 1 CD8A
mitochondrial matrix 2 CAT, STAR
Extracellular side 1 ACHE
centriolar satellite 1 DBH
ciliary membrane 1 DRD2
Nucleus membrane 1 SLC22A3
external side of plasma membrane 2 CD4, CD8A
dendritic spine 1 DRD2
perikaryon 1 DRD2
Early endosome 1 CD4
apical part of cell 1 CA2
Single-pass type II membrane protein 1 DBH
postsynaptic membrane 3 DRD2, GRIN2B, SLC6A4
Apical cell membrane 1 SLC22A3
Mitochondrion inner membrane 1 CYP11B1
Membrane raft 2 CD4, SLC6A4
Cell junction, focal adhesion 1 SLC6A4
Cytoplasm, cytoskeleton 1 GRIN2B
focal adhesion 2 CAT, SLC6A4
GABA-ergic synapse 2 DRD2, NPY
Peroxisome 1 CAT
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
mitochondrial intermembrane space 1 STAR
secretory granule 1 TRH
lateral plasma membrane 1 DRD2
Nucleus outer membrane 1 SLC22A3
nuclear outer membrane 1 SLC22A3
Postsynaptic cell membrane 1 GRIN2B
Late endosome 1 GRIN2B
receptor complex 2 ADRB3, CD8A
Cell projection, neuron projection 1 SLC6A4
neuron projection 2 GRIN2B, SLC6A4
cilium 1 DRD2
cytoskeleton 1 GRIN2B
non-motile cilium 1 DRD2
Basolateral cell membrane 1 SLC22A3
Lipid-anchor, GPI-anchor 1 ACHE
sperm flagellum 1 DRD2
Endomembrane system 2 SLC22A3, SLC6A4
Cell projection, dendrite 2 GRIN2B, HTR1A
side of membrane 1 ACHE
myelin sheath 1 CA2
basal plasma membrane 1 SLC22A3
synaptic membrane 1 GRIN2B
exocytic vesicle 1 IGF1
plasma membrane raft 1 CD8A
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, DBH
secretory granule membrane 1 DBH
endoplasmic reticulum lumen 1 CD4
platelet alpha granule lumen 1 IGF1
axon terminus 1 DRD2
endocytic vesicle 1 DRD2
postsynaptic density membrane 1 GRIN2B
neuronal dense core vesicle 1 NPY
clathrin-coated endocytic vesicle membrane 1 CD4
synaptic cleft 1 ACHE
NMDA selective glutamate receptor complex 1 GRIN2B
[Isoform 1]: Cell membrane 1 CD8A
dopaminergic synapse 1 DRD2
Cytoplasmic vesicle, secretory vesicle membrane 1 DBH
Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen 1 DBH
chromaffin granule lumen 1 DBH
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle 1 NPY
T cell receptor complex 2 CD4, CD8A
transport vesicle membrane 1 DBH
catalase complex 1 CAT
alphav-beta3 integrin-IGF-1-IGF1R complex 1 IGF1
insulin-like growth factor binding protein complex 1 IGF1
insulin-like growth factor ternary complex 1 IGF1
[Soluble dopamine beta-hydroxylase]: Cytoplasmic vesicle, secretory vesicle lumen 1 DBH
Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane 1 DBH
chromaffin granule membrane 1 DBH
G protein-coupled receptor complex 1 DRD2
[Isoform H]: Cell membrane 1 ACHE
serotonergic synapse 1 SLC6A4
interleukin-28 receptor complex 1 IFNLR1


文献列表

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