Hordenine (BioDeep_00000000393)

 

Secondary id: BioDeep_00000403189, BioDeep_00000410450

human metabolite PANOMIX_OTCML-2023 natural product


代谢物信息卡片


4-[2-(dimethylamino)ethyl]phenol

化学式: C10H15NO (165.1154)
中文名称: 大麦芽碱, 对二甲氨乙基苯酚
谱图信息: 最多检出来源 Mus musculus(plant) 12.21%

Reviewed

Last reviewed on 2024-10-24.

Cite this Page

Hordenine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/hordenine (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000000393). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CN(C)CCC1=CC=C(C=C1)O
InChI: InChI=1S/C10H15NO/c1-11(2)8-7-9-3-5-10(12)6-4-9/h3-6,12H,7-8H2,1-2H3

描述信息

Hordenine is a potent phenylethylamine alkaloid with antibacterial and antibiotic properties produced in nature by several varieties of plants in the family Cactacea. The major source of hordenine in humans is beer brewed from barley. Hordenine in urine interferes with tests for morphine, heroin and other opioid drugs. Hordenine is a biomarker for the consumption of beer
Hordenine is a phenethylamine alkaloid. It has a role as a human metabolite and a mouse metabolite.
Hordenine is a natural product found in Cereus peruvianus, Mus musculus, and other organisms with data available.
See also: Selenicereus grandiflorus stem (part of).
Alkaloid from Hordeum vulgare (barley)
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2289
Hordenine, an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production[1].


Hordenine. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=539-15-1 (retrieved 2024-10-24) (CAS RN: 539-15-1). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

同义名列表

50 个代谢物同义名

N,N-Dimethyl-4-hydroxy-.beta.-phenethylamine; 2-(4-Hydroxyphenyl)-N,N-dimethylethylamine; N,N-Dimethyl-2-(4-hydroxyphenyl)ethylamine; N,N-Dimethyl-4-hydroxy-beta-phenethylamine; Ordenina (sulfate); Peyocactine (sulfate); N,N-Dimethyl-4-hydroxy-b-phenethylamine; N,N-Dimethyl-4-hydroxy-β-phenethylamine; N,N-dimethyl-4-hydroxyphenylethylamine; 4-Hydroxy-N,N-dimethylphenethylamine; N,N-Dimethyl-p-hydroxyphenethylamine; p-Hydroxy-N,N-dimethylphenethylamine; N-dimethyl-4-hydroxyphenylethylamine; Phenol, 4-[2-(dimethylamino)ethyl]-; PHENOL, P-(2-(DIMETHYLAMINO)ETHYL)-; Phenol, p-[2-(dimethylamino)ethyl]-; 4-[2-(Dimethylamino)ethyl]phenol #; 4-(2-(Dimethylamino)ethyl)phenol; p-[2-(Dimethylamino)ethyl]phenol; 4-[2-(Dimethylamino)ethyl]phenol; P-(2-(DIMETHYLAMINO)ETHYL)PHENOL; 4-(2-dimethylaminoethyl)-phenol; 4-(2-Dimethylaminoethyl)phenol; Hordenine, analytical standard; p-(2-Dimethylaminoethyl)phenol; Hordenine, >=97.0\\% (HPLC); hordenine sulfate (2:1); hordenine hydrochloride; hordenine sulfate (1:1); Ordenina;Peyocactine; N,N-dimethyltyramine; Hordenine (sulfate); HORDENINE [WHO-DD]; HORDENINE [INCI]; Tox21_111748_1; HORDENINE [MI]; Tox21_111748; Peyocactine; Eremursine; Hordenine; Eremursin; Hordenin; Ordenine; Anhaline; Ordenina; Hordetin; Anhalin; Cactine; Hordenine; Hordenine; Hordenine



数据库引用编号

42 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

369 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 15 AIMP2, AKT1, AXIN2, CCND1, CTNNB1, HNRNPK, LEF1, MAPK8, MARVELD1, S1PR1, SNCA, SPHK1, STAT3, TJP1, TYR
Peripheral membrane protein 2 SPHK1, TJP1
Endosome membrane 1 SPHK1
Endoplasmic reticulum membrane 1 DRD1
Nucleus 15 AIMP2, AKT1, AXIN2, CCND1, CTNNB1, DRD1, HNRNPF, HNRNPK, LEF1, MAPK8, MARVELD1, SNCA, SPHK1, STAT3, TJP1
cytosol 11 AIMP2, AKT1, AXIN2, CCND1, CTNNB1, HNRNPF, MAPK8, SNCA, SPHK1, STAT3, TJP1
dendrite 1 DRD2
centrosome 3 AXIN2, CCND1, CTNNB1
nucleoplasm 10 AKT1, CCND1, CTNNB1, HNRNPF, HNRNPK, LEF1, MAPK8, S1PR1, SPHK1, STAT3
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 8 AKT1, CTNNB1, DRD1, DRD2, MARVELD1, S1PR1, SPHK1, TJP1
Cytoplasmic side 1 TJP1
lamellipodium 2 AKT1, CTNNB1
Cell projection, axon 1 SNCA
Early endosome membrane 1 SPHK1
Multi-pass membrane protein 4 DRD1, DRD2, MARVELD1, S1PR1
Golgi apparatus membrane 1 DRD2
Synapse 6 CTNNB1, DRD2, HNRNPF, MAPK8, SNCA, SPHK1
cell cortex 3 AKT1, CTNNB1, SNCA
cell junction 2 CTNNB1, TJP1
glutamatergic synapse 4 AKT1, CTNNB1, DRD1, DRD2
Golgi membrane 1 DRD2
growth cone 1 SNCA
neuronal cell body 1 SNCA
postsynapse 2 AKT1, SNCA
presynaptic membrane 3 CTNNB1, DRD1, DRD2
Cytoplasm, cytosol 1 AIMP2
Lysosome 2 SNCA, TYR
Presynapse 2 S1PR1, SPHK1
acrosomal vesicle 1 DRD2
endosome 1 S1PR1
plasma membrane 12 AKT1, AXIN2, CTNNB1, DRD1, DRD2, HNRNPF, MARVELD1, S1PR1, SNCA, SPHK1, STAT3, TJP1
synaptic vesicle membrane 2 DRD2, SNCA
Membrane 8 AIMP2, AKT1, CTNNB1, HNRNPF, HNRNPK, MARVELD1, SNCA, SPHK1
apical plasma membrane 1 TJP1
axon 3 DRD2, MAPK8, SNCA
basolateral plasma membrane 2 CTNNB1, TJP1
extracellular exosome 2 CTNNB1, HNRNPK
extracellular space 2 IL6, SNCA
perinuclear region of cytoplasm 3 CTNNB1, SNCA, TYR
Schaffer collateral - CA1 synapse 1 CTNNB1
Cell junction, tight junction 1 TJP1
adherens junction 2 CTNNB1, TJP1
apicolateral plasma membrane 2 CTNNB1, TJP1
bicellular tight junction 3 CCND1, CTNNB1, TJP1
gap junction 1 TJP1
intercalated disc 1 TJP1
intercellular canaliculus 1 TJP1
mitochondrion 3 PDK3, SNCA, TJP1
protein-containing complex 4 AKT1, CTNNB1, SNCA, TJP1
intracellular membrane-bounded organelle 3 S1PR1, SPHK1, TYR
Single-pass type I membrane protein 1 TYR
Secreted 2 IL6, SNCA
extracellular region 2 IL6, SNCA
mitochondrial matrix 1 PDK3
anchoring junction 1 HNRNPK
transcription regulator complex 3 CTNNB1, LEF1, STAT3
ciliary membrane 2 DRD1, DRD2
Nucleus membrane 1 CCND1
nuclear membrane 1 CCND1
external side of plasma membrane 1 S1PR1
actin cytoskeleton 1 SNCA
dendritic spine 2 DRD1, DRD2
perikaryon 1 DRD2
Z disc 1 CTNNB1
beta-catenin destruction complex 2 AXIN2, CTNNB1
microtubule cytoskeleton 1 AKT1
nucleolus 1 PDK3
Wnt signalosome 1 CTNNB1
Melanosome membrane 1 TYR
Membrane, clathrin-coated pit 1 SPHK1
apical part of cell 2 CTNNB1, TJP1
cell-cell junction 2 AKT1, CTNNB1
clathrin-coated pit 1 SPHK1
Golgi-associated vesicle 1 TYR
vesicle 1 AKT1
postsynaptic membrane 3 CTNNB1, DRD1, DRD2
Membrane raft 1 S1PR1
Cytoplasm, cytoskeleton 2 CTNNB1, MARVELD1
focal adhesion 2 CTNNB1, HNRNPK
spindle 1 AKT1
GABA-ergic synapse 2 DRD1, DRD2
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
Cell projection, dendritic spine 1 DRD1
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
fascia adherens 1 CTNNB1
lateral plasma membrane 2 CTNNB1, DRD2
ciliary basal body 1 AKT1
cilium 2 DRD1, DRD2
chromatin 3 HNRNPK, LEF1, STAT3
cell projection 2 HNRNPK, TJP1
cell periphery 1 CTNNB1
supramolecular fiber 1 SNCA
cytoskeleton 1 MARVELD1
Cell projection, podosome 2 HNRNPK, TJP1
podosome 2 HNRNPK, TJP1
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
spindle pole 1 CTNNB1
non-motile cilium 2 DRD1, DRD2
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
spliceosomal complex 1 HNRNPK
sperm flagellum 1 DRD2
Endomembrane system 1 CTNNB1
Nucleus, nucleoplasm 1 HNRNPK
Cell projection, dendrite 1 DRD1
Melanosome 1 TYR
cytoplasmic stress granule 1 HNRNPK
euchromatin 1 CTNNB1
endoplasmic reticulum lumen 1 IL6
transcription repressor complex 1 CCND1
axon terminus 2 DRD2, SNCA
endocytic vesicle 2 DRD2, SPHK1
tight junction 1 TJP1
beta-catenin-TCF complex 2 CTNNB1, LEF1
presynaptic active zone cytoplasmic component 1 CTNNB1
ribonucleoprotein complex 2 HNRNPF, HNRNPK
protein-DNA complex 2 CTNNB1, LEF1
basal dendrite 1 MAPK8
apical junction complex 1 TJP1
dopaminergic synapse 1 DRD2
catalytic step 2 spliceosome 2 HNRNPF, HNRNPK
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
catenin complex 1 CTNNB1
Cell projection, cilium membrane 1 DRD1
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
inclusion body 1 SNCA
interleukin-6 receptor complex 1 IL6
cyclin D1-CDK4 complex 1 CCND1
G protein-coupled receptor complex 2 DRD1, DRD2
beta-catenin-TCF7L2 complex 1 CTNNB1
cyclin D1-CDK6 complex 1 CCND1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1


文献列表

  • Hongli Li, Min Gao, Ziyu Chen, Zhenyu Zhou, Wei Li, Xiaoyang Zhang, Xi Jiang, Lingling Luo, Fei Li, Gaorui Wang, Yu Zhang, Xingxu Huang, Jingning Zhu, Shengjie Fan, Xiaojun Wu, Cheng Huang. Hordenine improves Parkinsonian-like motor deficits in mice and nematodes by activating dopamine D2 receptor-mediated signaling. Phytotherapy research : PTR. 2023 Mar; ?(?):. doi: 10.1002/ptr.7790. [PMID: 36883794]
  • Meghan Grace Appley, Megan Isabella Chambers, Rabi Ann Musah. Quantification of hordenine in a complex plant matrix by direct analysis in real time-high-resolution mass spectrometry: Application to the "plant of concern" Sceletium tortuosum. Drug testing and analysis. 2022 Apr; 14(4):604-612. doi: 10.1002/dta.3193. [PMID: 34750996]
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  • Monika Sobiech, Joanna Giebułtowicz, Piotr Luliński. Theoretical and experimental proof for selective response of imprinted sorbent - analysis of hordenine in human urine. Journal of chromatography. A. 2020 Feb; 1613(?):460677. doi: 10.1016/j.chroma.2019.460677. [PMID: 31727352]
  • Thomas Sommer, Thomas Göen, Nadja Budnik, Monika Pischetsrieder. Absorption, Biokinetics, and Metabolism of the Dopamine D2 Receptor Agonist Hordenine (N,N-Dimethyltyramine) after Beer Consumption in Humans. Journal of agricultural and food chemistry. 2020 Feb; 68(7):1998-2006. doi: 10.1021/acs.jafc.9b06029. [PMID: 31984737]
  • Jin-Wei Zhou, Ling-Yu Ruan, Hong-Juan Chen, Huai-Zhi Luo, Huan Jiang, Jun-Song Wang, Ai-Qun Jia. Inhibition of Quorum Sensing and Virulence in Serratia marcescens by Hordenine. Journal of agricultural and food chemistry. 2019 Jan; 67(3):784-795. doi: 10.1021/acs.jafc.8b05922. [PMID: 30609368]
  • Jin-Wei Zhou, Bo Hou, Gen-Yan Liu, Huan Jiang, Bing Sun, Zhen-Nan Wang, Ruo-Fu Shi, Yuan Xu, Rong Wang, Ai-Qun Jia. Attenuation of Pseudomonas aeruginosa biofilm by hordenine: a combinatorial study with aminoglycoside antibiotics. Applied microbiology and biotechnology. 2018 Nov; 102(22):9745-9758. doi: 10.1007/s00253-018-9315-8. [PMID: 30128579]
  • Shuhao Su, Meng Cao, Guangyuan Wu, Zi Long, Xiaodong Cheng, Junshu Fan, Zhongrui Xu, Hongfei Su, Yiming Hao, Ge Li, Jie Peng, Shuang Li, Xin Wang. Hordenine protects against hyperglycemia-associated renal complications in streptozotocin-induced diabetic mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Aug; 104(?):315-324. doi: 10.1016/j.biopha.2018.05.036. [PMID: 29775900]
  • Simon Lebecque, Jean-Marc Crowet, Laurence Lins, Benjamin M Delory, Patrick du Jardin, Marie-Laure Fauconnier, Magali Deleu. Interaction between the barley allelochemical compounds gramine and hordenine and artificial lipid bilayers mimicking the plant plasma membrane. Scientific reports. 2018 06; 8(1):9784. doi: 10.1038/s41598-018-28040-6. [PMID: 29955111]
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