4,4-Dioxystilbene (BioDeep_00000009773)

   


代谢物信息卡片


4-[(E)-2-(4-hydroxyphenyl)ethenyl]phenol

化学式: C14H12O2 (212.0837)
中文名称: 4,4-二羟基苯乙烯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1(/C=C/c2ccc(cc2)O)ccc(cc1)O
InChI: InChI=1S/C14H12O2/c15-13-7-3-11(4-8-13)1-2-12-5-9-14(16)10-6-12/h1-10,15-16H/b2-1+



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 16 AIMP2, ANXA5, APAF1, BIRC5, CASP3, CCNF, CDH1, CDH2, EDN1, GSTO2, GSTT2, KEAP1, MAPK8, PML, PTGS2, RRM2
Peripheral membrane protein 4 ANXA5, CTSB, PML, PTGS2
Endosome membrane 1 ECE1
Endoplasmic reticulum membrane 2 PML, PTGS2
Nucleus 11 AIMP2, APAF1, BIRC5, CASP3, CCNF, CDH1, GSTT2, KEAP1, MAPK8, PML, RRM2
cytosol 13 AIMP2, ANXA5, APAF1, BIRC5, CASP3, CCNF, CDH1, GSTO2, GSTT2, KEAP1, MAPK8, PML, RRM2
trans-Golgi network 1 CDH1
centrosome 1 CCNF
nucleoplasm 6 BIRC5, CASP3, CDH1, KEAP1, MAPK8, PML
Cell membrane 3 CDH1, CDH2, ECE1
Cytoplasmic side 1 PML
lamellipodium 2 CDH1, CDH2
Early endosome membrane 1 PML
Synapse 1 MAPK8
cell junction 3 CCNF, CDH1, CDH2
cell surface 1 CDH2
glutamatergic synapse 2 CASP3, CDH1
Golgi apparatus 1 CDH1
lysosomal membrane 1 ECE1
neuronal cell body 1 CASP3
postsynapse 1 CDH1
sarcolemma 2 ANXA5, CDH2
Cytoplasm, cytosol 2 AIMP2, GSTT2
Lysosome 1 CTSB
endosome 2 CDH1, ECE1
plasma membrane 3 CDH1, CDH2, ECE1
Membrane 6 AIMP2, ANXA5, APAF1, CDH1, CDH2, ECE1
apical plasma membrane 2 CDH2, CTSB
axon 1 MAPK8
basolateral plasma membrane 1 CDH2
caveola 1 PTGS2
extracellular exosome 8 ANXA5, APAF1, CDH1, CTSB, ECE1, GPX3, GSTO2, GSTT2
endoplasmic reticulum 2 KEAP1, PTGS2
extracellular space 3 CTSB, EDN1, GPX3
perinuclear region of cytoplasm 4 CCNF, CDH1, CTSB, ECE1
adherens junction 2 CDH1, CDH2
apicolateral plasma membrane 1 CDH2
intercalated disc 1 CDH2
protein-containing complex 3 APAF1, BIRC5, PTGS2
Microsome membrane 1 PTGS2
postsynaptic density 2 CASP3, CDH2
Single-pass type I membrane protein 2 CDH1, CDH2
Secreted 2 EDN1, GPX3
extracellular region 6 ANXA5, APAF1, CDH1, CTSB, EDN1, GPX3
cytoplasmic side of plasma membrane 1 CDH1
basal part of cell 1 EDN1
Extracellular side 1 CTSB
centriolar satellite 1 KEAP1
nuclear membrane 2 CDH1, PML
external side of plasma membrane 3 ANXA5, CTSB, ECE1
actin cytoskeleton 1 CDH1
microtubule cytoskeleton 1 BIRC5
nucleolus 1 PML
midbody 2 BIRC5, KEAP1
Early endosome 1 ECE1
apical part of cell 1 CDH2
cell-cell junction 1 CDH2
Single-pass type II membrane protein 1 ECE1
vesicle 1 ECE1
presynaptic active zone membrane 1 CDH2
Apical cell membrane 1 CTSB
Cell membrane, sarcolemma 1 CDH2
Cytoplasm, perinuclear region 1 CCNF
Cytoplasm, cytoskeleton, spindle 1 BIRC5
focal adhesion 2 ANXA5, CDH2
microtubule 1 BIRC5
spindle 1 BIRC5
Cell junction, adherens junction 2 CDH1, CDH2
flotillin complex 1 CDH1
Nucleus, PML body 1 PML
PML body 1 PML
collagen-containing extracellular matrix 3 ANXA5, CDH2, CTSB
fascia adherens 1 CDH2
lateral plasma membrane 1 CDH1
interphase microtubule organizing center 1 BIRC5
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Zymogen granule membrane 1 ANXA5
neuron projection 2 CDH2, PTGS2
Chromosome 1 BIRC5
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole 1 CCNF
centriole 2 BIRC5, CCNF
Secreted, extracellular space 1 CTSB
Golgi apparatus, trans-Golgi network 1 CDH1
chromosome, telomeric region 1 PML
nuclear chromosome 1 BIRC5
actin filament 1 KEAP1
Cul3-RING ubiquitin ligase complex 1 KEAP1
Chromosome, centromere 1 BIRC5
Chromosome, centromere, kinetochore 1 BIRC5
Melanosome 1 CTSB
plasma membrane raft 1 CDH2
ficolin-1-rich granule lumen 2 APAF1, CTSB
secretory granule lumen 1 APAF1
endoplasmic reticulum lumen 2 CDH2, PTGS2
nuclear matrix 1 PML
kinetochore 1 BIRC5
transport vesicle 1 EDN1
anaphase-promoting complex 1 CDH1
apoptosome 1 APAF1
chromosome, centromeric region 1 BIRC5
vesicle membrane 1 ANXA5
chromosome passenger complex 1 BIRC5
[Isoform 2]: Nucleus 1 CDH1
cytoplasmic microtubule 1 BIRC5
spindle microtubule 1 BIRC5
survivin complex 1 BIRC5
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
postsynaptic specialization membrane 1 CDH2
apical junction complex 1 CDH1
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
Cell junction, desmosome 2 CDH1, CDH2
desmosome 2 CDH1, CDH2
catenin complex 2 CDH1, CDH2
cyclin-dependent protein kinase holoenzyme complex 1 CCNF
peptidase inhibitor complex 1 CTSB
rough endoplasmic reticulum lumen 1 EDN1
inclusion body 1 KEAP1
Weibel-Palade body 2 ECE1, EDN1
endolysosome lumen 1 CTSB
endothelial microparticle 1 ANXA5
SCF ubiquitin ligase complex 1 CCNF
ribonucleoside-diphosphate reductase complex 1 RRM2


文献列表

  • Wan Chen, Samuel Chao Ming Yeo, Mai Gamal Ahmed Ahmed Elhennawy, Xiaoqiang Xiang, Hai-Shu Lin. Determination of naturally occurring resveratrol analog trans-4,4'-dihydroxystilbene in rat plasma by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study. Analytical and bioanalytical chemistry. 2015 Jul; 407(19):5793-801. doi: 10.1007/s00216-015-8762-7. [PMID: 25998136]
  • Huixiao Hong, William S Branham, Hui Wen Ng, Carrie L Moland, Stacey L Dial, Hong Fang, Roger Perkins, Daniel Sheehan, Weida Tong. Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein. Toxicological sciences : an official journal of the Society of Toxicology. 2015 Feb; 143(2):333-48. doi: 10.1093/toxsci/kfu231. [PMID: 25349334]
  • Tania Coppa, Maria Claudia Lazzè, Ornella Cazzalini, Paola Perucca, Roberto Pizzala, Livia Bianchi, Lucia Anna Stivala, Luca Forti, Cristina Maccario, Vanio Vannini, Monica Savio. Structure-activity relationship of resveratrol and its analogue, 4,4'-dihydroxy-trans-stilbene, toward the endothelin axis in human endothelial cells. Journal of medicinal food. 2011 Oct; 14(10):1173-80. doi: 10.1089/jmf.2010.0272. [PMID: 21554123]
  • Gui-Juan Fan, Xiao-Da Liu, Yi-Ping Qian, Ya-Jing Shang, Xiu-Zhuang Li, Fang Dai, Jian-Guo Fang, Xiao-Ling Jin, Bo Zhou. 4,4'-Dihydroxy-trans-stilbene, a resveratrol analogue, exhibited enhanced antioxidant activity and cytotoxicity. Bioorganic & medicinal chemistry. 2009 Mar; 17(6):2360-5. doi: 10.1016/j.bmc.2009.02.014. [PMID: 19251420]
  • Jin-Chun Cheng, Jian-Guo Fang, Wei-Feng Chen, Bo Zhou, Li Yang, Zhong-Li Liu. Structure-activity relationship studies of resveratrol and its analogues by the reaction kinetics of low density lipoprotein peroxidation. Bioorganic chemistry. 2006 Jun; 34(3):142-57. doi: 10.1016/j.bioorg.2006.04.001. [PMID: 16712899]
  • Hong Fang, Weida Tong, William S Branham, Carrie L Moland, Stacy L Dial, Huixiao Hong, Qian Xie, Roger Perkins, William Owens, Daniel M Sheehan. Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor. Chemical research in toxicology. 2003 Oct; 16(10):1338-58. doi: 10.1021/tx030011g. [PMID: 14565775]
  • Yu Jun Cai, Jian Guo Fang, Lan Ping Ma, Li Yang, Zhong Li Liu. Inhibition of free radical-induced peroxidation of rat liver microsomes by resveratrol and its analogues. Biochimica et biophysica acta. 2003 Jan; 1637(1):31-8. doi: 10.1016/s0925-4439(02)00174-6. [PMID: 12527404]
  • Jian-Guo Fang, Man Lu, Zhi-Hua Chen, Hui-He Zhu, Yan Li, Li Yang, Long-Min Wu, Zhong-Li Liu. Antioxidant effects of resveratrol and its analogues against the free-radical-induced peroxidation of linoleic acid in micelles. Chemistry (Weinheim an der Bergstrasse, Germany). 2002 Sep; 8(18):4191-8. doi: 10.1002/1521-3765(20020916)8:18<4191::aid-chem4191>3.0.co;2-s. [PMID: 12298009]
  • Christelle Privat, João Paulo Telo, Vania Bernardes-Genisson, Abel Vieira, Jean-Pierre Souchard, Françoise Nepveu. Antioxidant properties of trans-epsilon-viniferin as compared to stilbene derivatives in aqueous and nonaqueous media. Journal of agricultural and food chemistry. 2002 Feb; 50(5):1213-7. doi: 10.1021/jf010676t. [PMID: 11853506]