Paxilline (BioDeep_00000009574)

human metabolite PANOMIX_OTCML-2023 Endogenous

代谢物信息卡片

化学式: C27H33NO4 (435.2409458000001)
中文名称: 蕈青霉素, 蕈青霉素
谱图信息: 最多检出来源 Homo sapiens(blood) 0.05%

分子结构信息

SMILES: CC(C)(O)C1OC2CCC3(C)C(O)(CCC4Cc5c([nH]c6ccccc56)C43C)C2=CC1=O
InChI: InChI=1S/C27H33NO4/c1-24(2,30)23-20(29)14-18-21(32-23)10-11-25(3)26(4)15(9-12-27(18,25)31)13-17-16-7-5-6-8-19(16)28-22(17)26/h5-8,14-15,21,23,28,30-31H,9-13H2,1-4H3/t15-,21-,23-,25+,26+,27+/m0/s1

描述信息

Paxilline is an indole diterpene alkaloid with formula C27H33NO4 isolated from Penicillium paxilli. It is a potent inhibitor of large conductance Ca2(+)- and voltage-activated K(+) (BK)-type channels. It has a role as a mycotoxin, a Penicillium metabolite, an anticonvulsant, an Aspergillus metabolite, a potassium channel blocker, a genotoxin, a geroprotector and an EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor. It is an organic heterohexacyclic compound, a tertiary alcohol, a terpenoid indole alkaloid, an enone and a diterpene alkaloid.
Paxilline is a natural product found in Penicillium thiersii, Aspergillus foveolatus, and other organisms with data available.
Tremorgenic agent from Penicillium paxilli, Acremonium lorii, Emericella foveolata, Emericella desertorum and Emericella striata Paxilline is a potassium channel blocker. Paxilline is a toxic, tremorgenic indole alkaloid produced by Penicillium paxilli
An indole diterpene alkaloid with formula C27H33NO4 isolated from Penicillium paxilli. It is a potent inhibitor of large conductance Ca2(+)- and voltage-activated K(+) (BK)-type channels.
Tremorgenic agent from Penicillium paxilli, Acremonium lorii, Emericella foveolata, Emericella desertorum and Emericella striata
D002317 - Cardiovascular Agents > D026902 - Potassium Channel Blockers
D049990 - Membrane Transport Modulators
Paxilline is an indole alkaloid mycotoxin from Penicillium paxilli, acts as a potent BK channels inhibitor by an almost exclusively closed-channel block mechanism. Paxilline also inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) with IC50s between 5 μM and 50 μM for differing isoforms. Paxilline possesses significant anticonvulsant activity[1][2][3].

同义名列表

29 个代谢物同义名

2H-1-Benzopyrano(5,6:6,7)indeno(1,2-b)indol-3(4bh)-one, 5,6,6a,7,12,12b,12c,13,14,14a-decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-, (2-alpha,4b-beta,6a-alpha,12b-beta,12c-alpha,14a-beta)-; 2H-Pyrano[2,3:5,6]benz[1,2:6,7]indeno[1,2-b]indol-3(4bH)-one, 5,6,6a,7,12,12b,12c,13,14,14a-decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-, (2R,4bS,6aS,12bS,12cR,14aS)-rel-; 2H-Pyrano(2,3:5,6)benz(1,2:6,7)indeno(1,2-b)indol-3(4bH)-one, 5,6,6a,7,12,12b,12c,13,14,14a-decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-, (2R,4bS,6aS,12bS,12cR,14aS)-; (2R,4bS,6aS,12bS,12cR,14aS)-5,6,6a, 7,12,12b,12c,13,14,14a-Decahydro-4b-hydroxy-2-(1-h ydroxy-1-methylethyl)-12b,12c-dimethyl-2H-pyrano[2 ,3:5,6]benz[1,2:6,7]indeno[1,2-b]indol-3(4bH)-one; (2R,4bS,6aS,12bS,12cR,14aS)-5,6,6a,7,12,12b,12c,13,14,14a-Decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-2H-pyrano[2,3:5,6]benz[1,2:6,7]indeno[1,2-b]indol-3(4bH)-one; (2R,4bS,6aS,12bS,12cR,14aS)-4b-hydroxy-2-(2-hydroxypropan-2-yl)-12b,12c-dimethyl-5,6,6a,7,12,12b,12c,13,14,14a-decahydro-2H-[1]benzopyrano[5,6:6,7]indeno[1,2-b]indol-3(4bH)-one; (2R,4bS,6aS,12bS,12cR,14aS)-4b-hydroxy-2-(2-hydroxypropan-2-yl)-12b,12c-dimethyl-5,6,6a,7,12,12b,12c,13,14,14a-decahydro-2H-chromeno[5,6:6,7]indeno[1,2-b]indol-3(4bH)-one; (1s,2r,5s,7r,11s,14s)-11-hydroxy-7-(2-hydroxypropan-2-yl)-1,2-dimethyl-6-oxa-23-azahexacyclo[12.10.0.02,11.05,10.016,24.017,22]tetracosa-9,16(24),17,19,21-pentaen-8-one; (1S,2R,5S,7R,11S,14S)-11-hydroxy-7-(2-hydroxypropan-2-yl)-1,2-dimethyl-6-oxa-23-azahexacyclo[12.10.0.0²,¹¹.0⁵,¹⁰.0¹⁶,²⁴.0¹⁷,²²]tetracosa-9,16(24),17,19,21-pentaen-8-one; Paxilline, powder, >=98\\% (HPLC); Spectrum5_001975; UNII-3T9U9Z96L7; (+)-paxilline; KBio2_005283; KBio3_000293; KBio2_002715; KBio3_000294; KBio2_000147; Bio2_000627; IDI1_033897; Bio1_000128; Bio1_000617; Bio1_001106; Bio2_000147; 3T9U9Z96L7; Paxilline; C27H33NO4; PAXILINE; paxillin

数据库引用编号

22 个数据库交叉引用编号

ChEBI: CHEBI:34907
KEGG: C13782
PubChem: 105008
PubChem: 4697
HMDB: HMDB0030323
Metlin: METLIN69702
ChEMBL: CHEMBL410063
Wikipedia: Paxilline
MeSH: paxilline
ChemIDplus: 0057186251
MetaCyc: CPD-16744
KNApSAcK: C00023582
foodb: FDB002165
chemspider: 94753
CAS: 1233509-81-3
CAS: 57186-25-1
medchemexpress: HY-N6778
PMhub: MS000023367
MetaboLights: MTBLC34907
PubChem: 854027
NIKKAJI: J31.896E
RefMet: Paxilline

分类词条

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

paxilline and diprenylpaxilline biosynthesis: DMAPP + paxilline ⟶ 21,22-diprenylpaxilline + diphosphate

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

21 个相关的物种来源信息

70109 Penicillium paxilli:
1810909 Aspergillus desertorum:
469280 Aspergillus striatus:
210207 Aspergillus foveolatus:
5075 Penicillium camemberti: 10.1021/NP400304Q
4522 Lolium perenne: 10.1016/S0031-9422(00)82327-4
36645 Penicillium miczynskii: 10.1016/0040-4020(95)00138-X
40601 Claviceps paspali: 10.1021/JF902208W
116978 Penicillium thiersii: 10.1021/OL026424A
124418 Tolypocladium album: 10.1016/J.CHEMBIOL.2012.10.010
70109 Penicillium paxilli:
1810909 Aspergillus desertorum:
469280 Aspergillus striatus:
210207 Aspergillus foveolatus:
5075 Penicillium camemberti: 10.1021/NP400304Q
4522 Lolium perenne: 10.1016/S0031-9422(00)82327-4
36645 Penicillium miczynskii: 10.1016/0040-4020(95)00138-X
40601 Claviceps paspali: 10.1021/JF902208W
116978 Penicillium thiersii: 10.1021/OL026424A
124418 Tolypocladium album: 10.1016/J.CHEMBIOL.2012.10.010
9606 Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Griselda Awanis, Salonee Banerjee, Robert Johnson, Sathuwarman Raveenthiraraj, Aya Elmeligy, Derek Warren, Jelena Gavrilovic, Anastasia Sobolewski. HGF/c-Met/β1-integrin signalling axis induces tunneling nanotubes in A549 lung adenocarcinoma cells. Life science alliance. 2023 Oct; 6(10):. doi: 10.26508/lsa.202301953. [PMID: 37550007]
Chiao-Peng Hsu, Jonas Aretz, Arsenii Hordeichyk, Reinhard Fässler, Andreas R Bausch. Surface-induced phase separation of reconstituted nascent integrin clusters on lipid membranes. Proceedings of the National Academy of Sciences of the United States of America. 2023 08; 120(31):e2301881120. doi: 10.1073/pnas.2301881120. [PMID: 37494400]
Wuyun Lv, Yu Xiao, Zhe Xu, Hong Jiang, Qi Tong, Zhengyi Wang. The Paxillin MoPax1 Activates Mitogen-Activated Protein (MAP) Kinase Signaling Pathways and Autophagy through MAP Kinase Activator MoMka1 during Appressorium-Mediated Plant Infection by the Rice Blast Fungus Magnaporthe oryzae. mBio. 2022 12; 13(6):e0221822. doi: 10.1128/mbio.02218-22. [PMID: 36314807]
Chotchanit Sunrat, Jaturon Kwanthongdee, Kwanchanok Uppakara, Napason Chabang, Bamroong Munyoo, Patoomratana Tuchinda, Witchuda Saengsawang. Phyllanthus taxodiifolius Beille Disrupted N-cadherin, Vimentin, Paxillin and Actin Stress Fibers in Glioblastoma. Asian Pacific journal of cancer prevention : APJCP. 2022 Jul; 23(7):2379-2386. doi: 10.31557/apjcp.2022.23.7.2379. [PMID: 35901345]
Chloe E Snider, Rahul Bhattacharjee, Maya G Igarashi, Kathleen L Gould. Fission yeast paxillin contains two Cdc15 binding motifs for robust recruitment to the cytokinetic ring. Molecular biology of the cell. 2022 04; 33(4):br4. doi: 10.1091/mbc.e21-11-0560. [PMID: 35108037]
Qian Lu, Yongwei Lai, Hong Zhang, Kuang Ren, Wei Liu, Ying An, Jiahong Yao, Hongyan Fan. Hesperetin Inhibits TGF-β1-Induced Migration and Invasion of Triple Negative Breast Cancer MDA-MB-231 Cells via Suppressing Fyn/Paxillin/RhoA Pathway. Integrative cancer therapies. 2022 Jan; 21(?):15347354221086900. doi: 10.1177/15347354221086900. [PMID: 35297710]
Susumu Ohya, Junko Kajikuri, Kyoko Endo, Hiroaki Kito, Elghareeb E Elboray, Takayoshi Suzuki. Ca2+ -activated K+ channel KCa 1.1 as a therapeutic target to overcome chemoresistance in three-dimensional sarcoma spheroid models. Cancer science. 2021 Sep; 112(9):3769-3783. doi: 10.1111/cas.15046. [PMID: 34181803]
Yun Chen, Han Zhao, Yan Xiao, Peijun Shen, Li Tan, Shaohui Zhang, Qiong Liu, Zhengrong Gao, Jie Zhao, Yaqiong Zhao, Yue Guo, Yunzhi Feng. Pan-cancer analysis reveals an immunological role and prognostic potential of PXN in human cancer. Aging. 2021 06; 13(12):16248-16266. doi: 10.18632/aging.203154. [PMID: 34135128]
Anna Selezneva, Minae Yoshida, Alasdair Gibb, Dean Willis. Nuclear BK channels regulate CREB phosphorylation in RAW264.7 macrophages. Pharmacological reports : PR. 2021 Jun; 73(3):881-890. doi: 10.1007/s43440-021-00229-z. [PMID: 33713314]
Qihui Fan, Yu Zheng, Xiaochen Wang, Ruipei Xie, Yu Ding, Boyi Wang, Xiaoyu Yu, Ying Lu, Liyu Liu, Yunliang Li, Ming Li, Yuanjin Zhao, Yang Jiao, Fangfu Ye. Dynamically Re-Organized Collagen Fiber Bundles Transmit Mechanical Signals and Induce Strongly Correlated Cell Migration and Self-Organization. Angewandte Chemie (International ed. in English). 2021 05; 60(21):11858-11867. doi: 10.1002/anie.202016084. [PMID: 33533087]
Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Marta Ripamonti, Nicolas Liaudet, Latifeh Azizi, Daniel Bouvard, Vesa P Hytönen, Bernhard Wehrle-Haller. Structural and functional analysis of LIM domain-dependent recruitment of paxillin to αvβ3 integrin-positive focal adhesions. Communications biology. 2021 03; 4(1):380. doi: 10.1038/s42003-021-01886-9. [PMID: 33782527]
Hye-Jin Kim, Eunmi Kim, Haesong Lee, Jae Woo Jung, Ji Eon Kim, Chan-Gi Pack, Jung Weon Lee. SLAC2B-dependent microtubule acetylation regulates extracellular matrix-mediated intracellular TM4SF5 traffic to the plasma membranes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2021 03; 35(3):e21369. doi: 10.1096/fj.202002138rr. [PMID: 33554392]
Federico Noto, Sandra Recuero, Julián Valencia, Beatrice Saporito, Domenico Robbe, Sergi Bonet, Augusto Carluccio, Marc Yeste. Inhibition of Potassium Channels Affects the Ability of Pig Spermatozoa to Elicit Capacitation and Trigger the Acrosome Exocytosis Induced by Progesterone. International journal of molecular sciences. 2021 Feb; 22(4):. doi: 10.3390/ijms22041992. [PMID: 33671466]
Treena Chatterjee, Sheng Zhang, Tressie A Posey, Joan Jacob, Ling Wu, Wangsheng Yu, Liezl E Francisco, Qingyun J Liu, Kendra S Carmon. Anti-GPR56 monoclonal antibody potentiates GPR56-mediated Src-Fak signaling to modulate cell adhesion. The Journal of biological chemistry. 2021 Jan; 296(?):100261. doi: 10.1016/j.jbc.2021.100261. [PMID: 33837725]
Nada Bulus, Kyle L Brown, Glenda Mernaugh, Anika Böttcher, Xinyu Dong, Charles R Sanders, Ambra Pozzi, Reinhard Fässler, Roy Zent. Disruption of the integrin-linked kinase (ILK) pseudokinase domain affects kidney development in mice. The Journal of biological chemistry. 2021 Jan; 296(?):100361. doi: 10.1016/j.jbc.2021.100361. [PMID: 33539921]
Wenbiao Wang, Dingwen Hu, Yuqian Feng, Caifeng Wu, Yunting Song, Weiyong Liu, Aixin Li, Yingchong Wang, Keli Chen, Mingfu Tian, Feng Xiao, Qi Zhang, Weijie Chen, Pan Pan, Pin Wan, Yingle Liu, Huiyao Lan, Kailang Wu, Jianguo Wu. Paxillin mediates ATP-induced activation of P2X7 receptor and NLRP3 inflammasome. BMC biology. 2020 11; 18(1):182. doi: 10.1186/s12915-020-00918-w. [PMID: 33243234]
Minglei Zhang, Li Chen, Yang Liu, Minghui Chen, Shuang Zhang, Daliang Kong. Sea cucumber Cucumaria frondosa fucoidan inhibits osteosarcoma adhesion and migration by regulating cytoskeleton remodeling. Oncology reports. 2020 08; 44(2):469-476. doi: 10.3892/or.2020.7614. [PMID: 32467988]
Chunlin Chen, Yanxi Wang, Si Chen, Xiaofeng Ruan, Huiyan Liao, Yingxuan Zhang, Jianhua Sun, Jie Gao, Gaopi Deng. Genistein inhibits migration and invasion of cervical cancer HeLa cells by regulating FAK-paxillin and MAPK signaling pathways. Taiwanese journal of obstetrics & gynecology. 2020 May; 59(3):403-408. doi: 10.1016/j.tjog.2020.03.012. [PMID: 32416888]
Shih-Han Huang, Yung-Hsi Kao, Christo J F Muller, Elizabeth Joubert, Chih-Pin Chuu. Aspalathin-rich green Aspalathus linearis extract suppresses migration and invasion of human castration-resistant prostate cancer cells via inhibition of YAP signaling. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Apr; 69(?):153210. doi: 10.1016/j.phymed.2020.153210. [PMID: 32217447]
Irene Ramos-Álvarez, Lingaku Lee, Robert T Jensen. Group II p21-activated kinase, PAK4, is needed for activation of focal adhesion kinases, MAPK, GSK3, and β-catenin in rat pancreatic acinar cells. American journal of physiology. Gastrointestinal and liver physiology. 2020 03; 318(3):G490-G503. doi: 10.1152/ajpgi.00229.2019. [PMID: 31984786]
Shuna Cui, Qingqing Wu, Juan Wang, Min Li, Jing Qian, Shihua Li. Quercetin inhibits LPS-induced macrophage migration by suppressing the iNOS/FAK/paxillin pathway and modulating the cytoskeleton. Cell adhesion & migration. 2019 12; 13(1):1-12. doi: 10.1080/19336918.2018.1486142. [PMID: 29945484]
Xiaoting Ma, Anindita Biswas, Stephen R Hammes. Paxillin regulated genomic networks in prostate cancer. Steroids. 2019 11; 151(?):108463. doi: 10.1016/j.steroids.2019.108463. [PMID: 31344408]
Roumen Pankov, Albena Momchilova, Nadezhda Stefanova, Kenneth M Yamada. Characterization of stitch adhesions: Fibronectin-containing cell-cell contacts formed by fibroblasts. Experimental cell research. 2019 11; 384(1):111616. doi: 10.1016/j.yexcr.2019.111616. [PMID: 31499058]
Carl J May, Gavin I Welsh, Musleeha Chesor, Phillipa J Lait, Lauren P Schewitz-Bowers, Richard W J Lee, Moin A Saleem. Human Th17 cells produce a soluble mediator that increases podocyte motility via signaling pathways that mimic PAR-1 activation. American journal of physiology. Renal physiology. 2019 10; 317(4):F913-F921. doi: 10.1152/ajprenal.00093.2019. [PMID: 31339775]
Karin Legerstee, Bart Geverts, Johan A Slotman, Adriaan B Houtsmuller. Dynamics and distribution of paxillin, vinculin, zyxin and VASP depend on focal adhesion location and orientation. Scientific reports. 2019 07; 9(1):10460. doi: 10.1038/s41598-019-46905-2. [PMID: 31320676]
Hong Wang, Paul F Pilch, Libin Liu. Cavin-1/PTRF mediates insulin-dependent focal adhesion remodeling and ameliorates high-fat diet-induced inflammatory responses in mice. The Journal of biological chemistry. 2019 07; 294(27):10544-10552. doi: 10.1074/jbc.ra119.008824. [PMID: 31126986]
Tae-Yong Choi, Seung-Hyun Lee, Soo-Jeong Kim, Youhwa Jo, Chul-Seung Park, Se-Young Choi. BK channel blocker paxilline attenuates thalidomide-caused synaptic and cognitive dysfunctions in mice. Scientific reports. 2018 12; 8(1):17653. doi: 10.1038/s41598-018-36367-3. [PMID: 30518785]
Barbara Noethel, Lena Ramms, Georg Dreissen, Marco Hoffmann, Ronald Springer, Matthias Rübsam, Wolfgang H Ziegler, Carien M Niessen, Rudolf Merkel, Bernd Hoffmann. Transition of responsive mechanosensitive elements from focal adhesions to adherens junctions on epithelial differentiation. Molecular biology of the cell. 2018 09; 29(19):2317-2325. doi: 10.1091/mbc.e17-06-0387. [PMID: 30044710]
Zhongwen Chen, Dongmyung Oh, Kabir H Biswas, Cheng-Han Yu, Ronen Zaidel-Bar, Jay T Groves. Spatially modulated ephrinA1:EphA2 signaling increases local contractility and global focal adhesion dynamics to promote cell motility. Proceedings of the National Academy of Sciences of the United States of America. 2018 06; 115(25):E5696-E5705. doi: 10.1073/pnas.1719961115. [PMID: 29866846]
Addie E Embry, Zhenan Liu, Joel M Henderson, F Jefferson Byfield, Liping Liu, Joonho Yoon, Zhenzhen Wu, Katrina Cruz, Sara Moradi, C Barton Gillombardo, Rihanna Z Hussain, Richard Doelger, Olaf Stuve, Audrey N Chang, Paul A Janmey, Leslie A Bruggeman, R Tyler Miller. Similar Biophysical Abnormalities in Glomeruli and Podocytes from Two Distinct Models. Journal of the American Society of Nephrology : JASN. 2018 05; 29(5):1501-1512. doi: 10.1681/asn.2017050475. [PMID: 29572404]
Nobuhiro Kasai, Ailijiang Kadeer, Mihoko Kajita, Sayaka Saitoh, Susumu Ishikawa, Takeshi Maruyama, Yasuyuki Fujita. The paxillin-plectin-EPLIN complex promotes apical elimination of RasV12-transformed cells by modulating HDAC6-regulated tubulin acetylation. Scientific reports. 2018 02; 8(1):2097. doi: 10.1038/s41598-018-20146-1. [PMID: 29391412]
Na Wang, Ying-Hong Hu, Li-Da Su. Potassium channels-mediated electrophysiologic responses are inhibited by cytosolic phospholipase A2α ablation. Neuroreport. 2018 Jan; 29(1):59-64. doi: 10.1097/wnr.0000000000000933. [PMID: 29112675]
Fatemeh Dubois, Kyle Alpha, Christopher E Turner. Paxillin regulates cell polarization and anterograde vesicle trafficking during cell migration. Molecular biology of the cell. 2017 Dec; 28(26):3815-3831. doi: 10.1091/mbc.e17-08-0488. [PMID: 29046398]
Wen-Chung Tsai, Tung-Yang Yu, Li-Ping Lin, Mioa-Sui Lin, Ting-Ta Tsai, Jong-Hwei S Pang. Platelet rich plasma promotes skeletal muscle cell migration in association with up-regulation of FAK, paxillin, and F-Actin formation. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2017 11; 35(11):2506-2512. doi: 10.1002/jor.23547. [PMID: 28233384]
Lemen Pan, Guanfeng Yu, Xiangjian Chen, Xiaoqiang Li. Nicotinic acid inhibits angiogenesis likely through cytoskeleton remodeling. Organogenesis. 2017 10; 13(4):183-191. doi: 10.1080/15476278.2017.1364829. [PMID: 28933636]
Hsin-Ying Lu, Chun-Yao Huang, Chun-Ming Shih, Yi-Wen Lin, Chein-Sung Tsai, Feng-Yen Lin, Chun-Che Shih. A potential contribution of dipeptidyl peptidase-4 by the mediation of monocyte differentiation in the development and progression of abdominal aortic aneurysms. Journal of vascular surgery. 2017 10; 66(4):1217-1226.e1. doi: 10.1016/j.jvs.2016.05.093. [PMID: 27887857]
Ayaka Ichikawa Nagasato, Hiroshi Yamashita, Michinori Matsuo, Kazumitsu Ueda, Noriyuki Kioka. The distribution of vinculin to lipid rafts plays an important role in sensing stiffness of extracellular matrix. Bioscience, biotechnology, and biochemistry. 2017 Jun; 81(6):1136-1147. doi: 10.1080/09168451.2017.1289074. [PMID: 28485208]
Melanie K Laird, Michaela Turancova, Bronwyn M McAllan, Christopher R Murphy, Michael B Thompson. Uterine focal adhesion dynamics during pregnancy in a marsupial (Sminthopsis crassicaudata; Dasyuridae). Anatomical record (Hoboken, N.J. : 2007). 2017 Jun; 300(6):1150-1159. doi: 10.1002/ar.23535. [PMID: 27997081]
Shuna Cui, Juan Wang, Qingqing Wu, Jing Qian, Changshui Yang, Ping Bo. Genistein inhibits the growth and regulates the migration and invasion abilities of melanoma cells via the FAK/paxillin and MAPK pathways. Oncotarget. 2017 Mar; 8(13):21674-21691. doi: 10.18632/oncotarget.15535. [PMID: 28423510]
Juliana Perrone Bezerra de Menezes, Amrita Koushik, Satarupa Das, Can Guven, Ariel Siegel, Maria Fernanda Laranjeira-Silva, Wolfgang Losert, Norma W Andrews. Leishmania infection inhibits macrophage motility by altering F-actin dynamics and the expression of adhesion complex proteins. Cellular microbiology. 2017 03; 19(3):. doi: 10.1111/cmi.12668. [PMID: 27641840]
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