Paxilline (BioDeep_00000009574)

 

Secondary id: BioDeep_00000404697

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


2H-1-Benzopyrano(5,6:6,7)indeno(1,2-b)indol-3(4bh)-one, 5,6,6a,7,12,12b,12c,13,14,14a-decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-, (2-alpha,4b-beta,6a-alpha,12b-beta,12c-alpha,14a-beta)-

化学式: C27H33NO4 (435.2409)
中文名称: 蕈青霉素
谱图信息: 最多检出来源 Homo sapiens(blood) 6.94%

分子结构信息

SMILES: CC(C)(O)C1OC2CCC3(C)C(O)(CCC4Cc5c([nH]c6ccccc56)C43C)C2=CC1=O
InChI: InChI=1S/C27H33NO4/c1-24(2,30)23-20(29)14-18-21(32-23)10-11-25(3)26(4)15(9-12-27(18,25)31)13-17-16-7-5-6-8-19(16)28-22(17)26/h5-8,14-15,21,23,28,30-31H,9-13H2,1-4H3/t15-,21-,23-,25+,26+,27+/m0/s1

描述信息

Paxilline is an indole diterpene alkaloid with formula C27H33NO4 isolated from Penicillium paxilli. It is a potent inhibitor of large conductance Ca2(+)- and voltage-activated K(+) (BK)-type channels. It has a role as a mycotoxin, a Penicillium metabolite, an anticonvulsant, an Aspergillus metabolite, a potassium channel blocker, a genotoxin, a geroprotector and an EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor. It is an organic heterohexacyclic compound, a tertiary alcohol, a terpenoid indole alkaloid, an enone and a diterpene alkaloid.
Paxilline is a natural product found in Penicillium thiersii, Aspergillus foveolatus, and other organisms with data available.
Tremorgenic agent from Penicillium paxilli, Acremonium lorii, Emericella foveolata, Emericella desertorum and Emericella striata Paxilline is a potassium channel blocker. Paxilline is a toxic, tremorgenic indole alkaloid produced by Penicillium paxilli
An indole diterpene alkaloid with formula C27H33NO4 isolated from Penicillium paxilli. It is a potent inhibitor of large conductance Ca2(+)- and voltage-activated K(+) (BK)-type channels.
Tremorgenic agent from Penicillium paxilli, Acremonium lorii, Emericella foveolata, Emericella desertorum and Emericella striata
D002317 - Cardiovascular Agents > D026902 - Potassium Channel Blockers
D049990 - Membrane Transport Modulators
Paxilline is an indole alkaloid mycotoxin from Penicillium paxilli, acts as a potent BK channels inhibitor by an almost exclusively closed-channel block mechanism. Paxilline also inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) with IC50s between 5 μM and 50 μM for differing isoforms. Paxilline possesses significant anticonvulsant activity[1][2][3].

同义名列表

30 个代谢物同义名

2H-1-Benzopyrano(5,6:6,7)indeno(1,2-b)indol-3(4bh)-one, 5,6,6a,7,12,12b,12c,13,14,14a-decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-, (2-alpha,4b-beta,6a-alpha,12b-beta,12c-alpha,14a-beta)-; 2H-Pyrano[2,3:5,6]benz[1,2:6,7]indeno[1,2-b]indol-3(4bH)-one, 5,6,6a,7,12,12b,12c,13,14,14a-decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-, (2R,4bS,6aS,12bS,12cR,14aS)-rel-; 2H-Pyrano(2,3:5,6)benz(1,2:6,7)indeno(1,2-b)indol-3(4bH)-one, 5,6,6a,7,12,12b,12c,13,14,14a-decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-, (2R,4bS,6aS,12bS,12cR,14aS)-; (2R,4bS,6aS,12bS,12cR,14aS)-5,6,6a, 7,12,12b,12c,13,14,14a-Decahydro-4b-hydroxy-2-(1-h ydroxy-1-methylethyl)-12b,12c-dimethyl-2H-pyrano[2 ,3:5,6]benz[1,2:6,7]indeno[1,2-b]indol-3(4bH)-one; (2R,4bS,6aS,12bS,12cR,14aS)-5,6,6a,7,12,12b,12c,13,14,14a-Decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-2H-pyrano[2,3:5,6]benz[1,2:6,7]indeno[1,2-b]indol-3(4bH)-one; (2R,4bS,6aS,12bS,12cR,14aS)-4b-hydroxy-2-(2-hydroxypropan-2-yl)-12b,12c-dimethyl-5,6,6a,7,12,12b,12c,13,14,14a-decahydro-2H-[1]benzopyrano[5,6:6,7]indeno[1,2-b]indol-3(4bH)-one; (2R,4bS,6aS,12bS,12cR,14aS)-4b-hydroxy-2-(2-hydroxypropan-2-yl)-12b,12c-dimethyl-5,6,6a,7,12,12b,12c,13,14,14a-decahydro-2H-chromeno[5,6:6,7]indeno[1,2-b]indol-3(4bH)-one; (1s,2r,5s,7r,11s,14s)-11-hydroxy-7-(2-hydroxypropan-2-yl)-1,2-dimethyl-6-oxa-23-azahexacyclo[12.10.0.02,11.05,10.016,24.017,22]tetracosa-9,16(24),17,19,21-pentaen-8-one; (1S,2R,5S,7R,11S,14S)-11-hydroxy-7-(2-hydroxypropan-2-yl)-1,2-dimethyl-6-oxa-23-azahexacyclo[12.10.0.0²,¹¹.0⁵,¹⁰.0¹⁶,²⁴.0¹⁷,²²]tetracosa-9,16(24),17,19,21-pentaen-8-one; Paxilline, powder, >=98\\% (HPLC); Spectrum5_001975; UNII-3T9U9Z96L7; (+)-paxilline; KBio2_005283; KBio3_000293; KBio2_002715; KBio3_000294; KBio2_000147; Bio2_000627; IDI1_033897; Bio1_000128; Bio1_000617; Bio1_001106; Bio2_000147; 3T9U9Z96L7; Paxilline; C27H33NO4; PAXILINE; paxillin; Paxilline



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

50 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 AKT1, CRK, EGFR, ITGB1, MAPK14, MARK2, PIK3CA, PRKX, PTK2B, RHOA, TNK1, VCL, VEGFA, ZYX
Peripheral membrane protein 2 TNK1, VCL
Endosome membrane 2 EGFR, ITGB1
Endoplasmic reticulum membrane 2 EGFR, RHOA
Nucleus 10 AKT1, CRK, EGFR, JUN, MAPK14, PRKX, PTK2B, RHOA, VEGFA, ZYX
cytosol 9 AKT1, CRK, MAPK14, PIK3CA, PRKCQ, PTK2B, RHOA, VCL, ZYX
dendrite 2 MARK2, PTK2B
phagocytic vesicle 1 ZYX
nucleoplasm 6 AKT1, CDH17, JUN, MAPK14, MARK2, PRKX
RNA polymerase II transcription regulator complex 1 JUN
Cell membrane 9 AKT1, CDH17, CRK, EGFR, GPRC5A, ITGB1, KCNMA1, RHOA, VCL
Lipid-anchor 1 RHOA
Cytoplasmic side 2 RHOA, VCL
Cleavage furrow 2 ITGB1, RHOA
lamellipodium 5 AKT1, ITGB1, PIK3CA, PTK2B, RHOA
ruffle membrane 3 EGFR, ITGB1, RHOA
Early endosome membrane 1 EGFR
Multi-pass membrane protein 2 GPRC5A, KCNMA1
Synapse 1 ITGB1
cell cortex 3 AKT1, PTK2B, RHOA
cell junction 4 CDH17, EGFR, ITGB1, RHOA
cell surface 4 CDH17, EGFR, ITGB1, VEGFA
glutamatergic synapse 5 AKT1, EGFR, MAPK14, PTK2B, RHOA
Golgi apparatus 1 VEGFA
Golgi membrane 1 EGFR
growth cone 1 PTK2B
neuromuscular junction 2 CRK, ITGB1
neuronal cell body 1 PTK2B
postsynapse 2 AKT1, RHOA
sarcolemma 2 ITGB1, VCL
Presynapse 1 PTK2B
endosome 2 EGFR, RHOA
plasma membrane 15 AKT1, CDH17, CRK, EGFR, GPRC5A, ITGB1, KCNMA1, MARK2, PIK3CA, PRKCQ, PTK2B, RHOA, TNK1, VCL, ZYX
Membrane 9 AKT1, CDH17, CRK, EGFR, ITGB1, KCNMA1, MARK2, TNK1, VEGFA
apical plasma membrane 2 EGFR, KCNMA1
basolateral plasma membrane 2 CDH17, EGFR
brush border 1 VCL
caveola 1 KCNMA1
extracellular exosome 6 CRK, GPRC5A, ITGB1, RHOA, VCL, VTN
endoplasmic reticulum 2 VEGFA, VTN
extracellular space 3 EGFR, VEGFA, VTN
perinuclear region of cytoplasm 4 EGFR, ITGB1, PIK3CA, PTK2B
Schaffer collateral - CA1 synapse 2 ITGB1, PTK2B
adherens junction 4 CDH17, VCL, VEGFA, ZYX
intercalated disc 2 ITGB1, PIK3CA
mitochondrion 2 MAPK14, MARK2
protein-containing complex 4 AKT1, CRK, EGFR, VCL
intracellular membrane-bounded organelle 2 GPRC5A, VTN
filopodium 1 ITGB1
postsynaptic density 1 PTK2B
Single-pass type I membrane protein 3 CDH17, EGFR, ITGB1
Secreted 2 VEGFA, VTN
extracellular region 4 MAPK14, VCL, VEGFA, VTN
cytoplasmic side of plasma membrane 1 RHOA
Single-pass membrane protein 1 CDH17
anchoring junction 1 ITGB1
transcription regulator complex 1 JUN
centriolar satellite 1 PRKCQ
nuclear membrane 1 EGFR
external side of plasma membrane 1 ITGB1
Extracellular vesicle 1 VCL
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 2 CRK, ZYX
dendritic spine 3 ITGB1, PTK2B, RHOA
microtubule cytoskeleton 1 AKT1
nucleolus 1 GPRC5A
midbody 1 RHOA
cell-cell junction 2 AKT1, VCL
recycling endosome 1 ITGB1
vesicle 3 AKT1, GPRC5A, RHOA
integrin alpha3-beta1 complex 1 ITGB1
postsynaptic membrane 1 KCNMA1
Cell membrane, sarcolemma 1 VCL
Cell projection, lamellipodium 2 ITGB1, RHOA
Cell projection, ruffle membrane 1 ITGB1
Membrane raft 3 EGFR, ITGB1, VCL
Cell junction, focal adhesion 3 ITGB1, VCL, ZYX
Cytoplasm, cytoskeleton 2 VCL, ZYX
focal adhesion 6 EGFR, ITGB1, PTK2B, RHOA, VCL, ZYX
spindle 1 AKT1
Cell junction, adherens junction 1 VCL
zonula adherens 1 VCL
extracellular matrix 1 VEGFA
basement membrane 1 VTN
intracellular vesicle 1 EGFR
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 VTN
secretory granule 1 VEGFA
fascia adherens 1 VCL
lateral plasma membrane 1 MARK2
nuclear speck 1 MAPK14
ruffle 1 ITGB1
receptor complex 3 EGFR, GPRC5A, ITGB1
ciliary basal body 1 AKT1
chromatin 1 JUN
cell projection 1 VCL
cell periphery 1 RHOA
cytoskeleton 4 PTK2B, RHOA, VCL, ZYX
Cell projection, podosome 1 VCL
podosome 1 VCL
Secreted, extracellular space 1 VTN
spindle pole 1 MAPK14
nuclear chromosome 1 JUN
Cytoplasm, cell cortex 1 RHOA
actin filament 1 MARK2
blood microparticle 1 VTN
postsynaptic density, intracellular component 1 PTK2B
Cytoplasmic vesicle membrane 1 GPRC5A
Cell projection, dendrite 2 MARK2, RHOA
Melanosome 1 ITGB1
euchromatin 1 JUN
cell body 1 PTK2B
stress fiber 1 ZYX
basal plasma membrane 1 EGFR
synaptic membrane 2 EGFR, ITGB1
voltage-gated potassium channel complex 1 KCNMA1
ficolin-1-rich granule lumen 2 MAPK14, VCL
secretory granule lumen 2 MAPK14, VCL
secretory granule membrane 1 RHOA
Golgi lumen 1 VTN
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
specific granule lumen 1 VCL
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
clathrin-coated endocytic vesicle membrane 1 EGFR
costamere 1 VCL
ficolin-1-rich granule membrane 1 RHOA
NMDA selective glutamate receptor complex 1 PTK2B
apical dendrite 1 PTK2B
apical junction complex 1 RHOA
cerebellar climbing fiber to Purkinje cell synapse 1 ITGB1
cell-substrate junction 1 VCL
catenin complex 1 CDH17
terminal web 1 VCL
integrin alpha10-beta1 complex 1 ITGB1
integrin complex 1 ITGB1
cell-cell contact zone 1 VCL
glial cell projection 1 ITGB1
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
protein complex involved in cell-matrix adhesion 1 VTN
peptidase inhibitor complex 1 VTN
transcription factor AP-1 complex 1 JUN
Parasitophorous vacuole 1 VTN
alphav-beta3 integrin-vitronectin complex 1 VTN
rough endoplasmic reticulum lumen 1 VTN
Cell projection, invadopodium membrane 1 ITGB1
[Isoform 5]: Cell membrane, sarcolemma 1 ITGB1
integrin alpha1-beta1 complex 1 ITGB1
integrin alpha11-beta1 complex 1 ITGB1
integrin alpha2-beta1 complex 1 ITGB1
integrin alpha4-beta1 complex 1 ITGB1
integrin alpha5-beta1 complex 1 ITGB1
integrin alpha6-beta1 complex 1 ITGB1
integrin alpha7-beta1 complex 1 ITGB1
integrin alpha8-beta1 complex 1 ITGB1
integrin alpha9-beta1 complex 1 ITGB1
integrin alphav-beta1 complex 1 ITGB1
myelin sheath abaxonal region 1 ITGB1
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
inner dense plaque of desmosome 1 VCL
outer dense plaque of desmosome 1 VCL
podosome ring 1 VCL
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
microtubule bundle 1 MARK2


文献列表

  • Griselda Awanis, Salonee Banerjee, Robert Johnson, Sathuwarman Raveenthiraraj, Aya Elmeligy, Derek Warren, Jelena Gavrilovic, Anastasia Sobolewski. HGF/c-Met/β1-integrin signalling axis induces tunneling nanotubes in A549 lung adenocarcinoma cells. Life science alliance. 2023 Oct; 6(10):. doi: 10.26508/lsa.202301953. [PMID: 37550007]
  • Chiao-Peng Hsu, Jonas Aretz, Arsenii Hordeichyk, Reinhard Fässler, Andreas R Bausch. Surface-induced phase separation of reconstituted nascent integrin clusters on lipid membranes. Proceedings of the National Academy of Sciences of the United States of America. 2023 08; 120(31):e2301881120. doi: 10.1073/pnas.2301881120. [PMID: 37494400]
  • Wuyun Lv, Yu Xiao, Zhe Xu, Hong Jiang, Qi Tong, Zhengyi Wang. The Paxillin MoPax1 Activates Mitogen-Activated Protein (MAP) Kinase Signaling Pathways and Autophagy through MAP Kinase Activator MoMka1 during Appressorium-Mediated Plant Infection by the Rice Blast Fungus Magnaporthe oryzae. mBio. 2022 12; 13(6):e0221822. doi: 10.1128/mbio.02218-22. [PMID: 36314807]
  • Chotchanit Sunrat, Jaturon Kwanthongdee, Kwanchanok Uppakara, Napason Chabang, Bamroong Munyoo, Patoomratana Tuchinda, Witchuda Saengsawang. Phyllanthus taxodiifolius Beille Disrupted N-cadherin, Vimentin, Paxillin and Actin Stress Fibers in Glioblastoma. Asian Pacific journal of cancer prevention : APJCP. 2022 Jul; 23(7):2379-2386. doi: 10.31557/apjcp.2022.23.7.2379. [PMID: 35901345]
  • Chloe E Snider, Rahul Bhattacharjee, Maya G Igarashi, Kathleen L Gould. Fission yeast paxillin contains two Cdc15 binding motifs for robust recruitment to the cytokinetic ring. Molecular biology of the cell. 2022 04; 33(4):br4. doi: 10.1091/mbc.e21-11-0560. [PMID: 35108037]
  • Qian Lu, Yongwei Lai, Hong Zhang, Kuang Ren, Wei Liu, Ying An, Jiahong Yao, Hongyan Fan. Hesperetin Inhibits TGF-β1-Induced Migration and Invasion of Triple Negative Breast Cancer MDA-MB-231 Cells via Suppressing Fyn/Paxillin/RhoA Pathway. Integrative cancer therapies. 2022 Jan; 21(?):15347354221086900. doi: 10.1177/15347354221086900. [PMID: 35297710]
  • Susumu Ohya, Junko Kajikuri, Kyoko Endo, Hiroaki Kito, Elghareeb E Elboray, Takayoshi Suzuki. Ca2+ -activated K+ channel KCa 1.1 as a therapeutic target to overcome chemoresistance in three-dimensional sarcoma spheroid models. Cancer science. 2021 Sep; 112(9):3769-3783. doi: 10.1111/cas.15046. [PMID: 34181803]
  • Yun Chen, Han Zhao, Yan Xiao, Peijun Shen, Li Tan, Shaohui Zhang, Qiong Liu, Zhengrong Gao, Jie Zhao, Yaqiong Zhao, Yue Guo, Yunzhi Feng. Pan-cancer analysis reveals an immunological role and prognostic potential of PXN in human cancer. Aging. 2021 06; 13(12):16248-16266. doi: 10.18632/aging.203154. [PMID: 34135128]
  • Anna Selezneva, Minae Yoshida, Alasdair Gibb, Dean Willis. Nuclear BK channels regulate CREB phosphorylation in RAW264.7 macrophages. Pharmacological reports : PR. 2021 Jun; 73(3):881-890. doi: 10.1007/s43440-021-00229-z. [PMID: 33713314]
  • Qihui Fan, Yu Zheng, Xiaochen Wang, Ruipei Xie, Yu Ding, Boyi Wang, Xiaoyu Yu, Ying Lu, Liyu Liu, Yunliang Li, Ming Li, Yuanjin Zhao, Yang Jiao, Fangfu Ye. Dynamically Re-Organized Collagen Fiber Bundles Transmit Mechanical Signals and Induce Strongly Correlated Cell Migration and Self-Organization. Angewandte Chemie (International ed. in English). 2021 05; 60(21):11858-11867. doi: 10.1002/anie.202016084. [PMID: 33533087]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Marta Ripamonti, Nicolas Liaudet, Latifeh Azizi, Daniel Bouvard, Vesa P Hytönen, Bernhard Wehrle-Haller. Structural and functional analysis of LIM domain-dependent recruitment of paxillin to αvβ3 integrin-positive focal adhesions. Communications biology. 2021 03; 4(1):380. doi: 10.1038/s42003-021-01886-9. [PMID: 33782527]
  • Hye-Jin Kim, Eunmi Kim, Haesong Lee, Jae Woo Jung, Ji Eon Kim, Chan-Gi Pack, Jung Weon Lee. SLAC2B-dependent microtubule acetylation regulates extracellular matrix-mediated intracellular TM4SF5 traffic to the plasma membranes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2021 03; 35(3):e21369. doi: 10.1096/fj.202002138rr. [PMID: 33554392]
  • Federico Noto, Sandra Recuero, Julián Valencia, Beatrice Saporito, Domenico Robbe, Sergi Bonet, Augusto Carluccio, Marc Yeste. Inhibition of Potassium Channels Affects the Ability of Pig Spermatozoa to Elicit Capacitation and Trigger the Acrosome Exocytosis Induced by Progesterone. International journal of molecular sciences. 2021 Feb; 22(4):. doi: 10.3390/ijms22041992. [PMID: 33671466]
  • Treena Chatterjee, Sheng Zhang, Tressie A Posey, Joan Jacob, Ling Wu, Wangsheng Yu, Liezl E Francisco, Qingyun J Liu, Kendra S Carmon. Anti-GPR56 monoclonal antibody potentiates GPR56-mediated Src-Fak signaling to modulate cell adhesion. The Journal of biological chemistry. 2021 Jan; 296(?):100261. doi: 10.1016/j.jbc.2021.100261. [PMID: 33837725]
  • Nada Bulus, Kyle L Brown, Glenda Mernaugh, Anika Böttcher, Xinyu Dong, Charles R Sanders, Ambra Pozzi, Reinhard Fässler, Roy Zent. Disruption of the integrin-linked kinase (ILK) pseudokinase domain affects kidney development in mice. The Journal of biological chemistry. 2021 Jan; 296(?):100361. doi: 10.1016/j.jbc.2021.100361. [PMID: 33539921]
  • Wenbiao Wang, Dingwen Hu, Yuqian Feng, Caifeng Wu, Yunting Song, Weiyong Liu, Aixin Li, Yingchong Wang, Keli Chen, Mingfu Tian, Feng Xiao, Qi Zhang, Weijie Chen, Pan Pan, Pin Wan, Yingle Liu, Huiyao Lan, Kailang Wu, Jianguo Wu. Paxillin mediates ATP-induced activation of P2X7 receptor and NLRP3 inflammasome. BMC biology. 2020 11; 18(1):182. doi: 10.1186/s12915-020-00918-w. [PMID: 33243234]
  • Minglei Zhang, Li Chen, Yang Liu, Minghui Chen, Shuang Zhang, Daliang Kong. Sea cucumber Cucumaria frondosa fucoidan inhibits osteosarcoma adhesion and migration by regulating cytoskeleton remodeling. Oncology reports. 2020 08; 44(2):469-476. doi: 10.3892/or.2020.7614. [PMID: 32467988]
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  • Shih-Han Huang, Yung-Hsi Kao, Christo J F Muller, Elizabeth Joubert, Chih-Pin Chuu. Aspalathin-rich green Aspalathus linearis extract suppresses migration and invasion of human castration-resistant prostate cancer cells via inhibition of YAP signaling. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Apr; 69(?):153210. doi: 10.1016/j.phymed.2020.153210. [PMID: 32217447]
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  • Shuna Cui, Qingqing Wu, Juan Wang, Min Li, Jing Qian, Shihua Li. Quercetin inhibits LPS-induced macrophage migration by suppressing the iNOS/FAK/paxillin pathway and modulating the cytoskeleton. Cell adhesion & migration. 2019 12; 13(1):1-12. doi: 10.1080/19336918.2018.1486142. [PMID: 29945484]
  • Xiaoting Ma, Anindita Biswas, Stephen R Hammes. Paxillin regulated genomic networks in prostate cancer. Steroids. 2019 11; 151(?):108463. doi: 10.1016/j.steroids.2019.108463. [PMID: 31344408]
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