heliomycin (BioDeep_00000009079)

   


代谢物信息卡片


Resistomycin

化学式: C22H16O6 (376.0947)
中文名称: 海利霉素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CC(=O)C2=C(C3=C4C5=C2C1=C(C=C5C(C(=C4C(=O)C=C3O)O)(C)C)O)O
InChI: InChI=1S/C22H16O6/c1-7-4-9(23)15-18-13(7)10(24)5-8-14(18)19-16(20(15)27)11(25)6-12(26)17(19)21(28)22(8,2)3/h4-6,24-25,27-28H,1-3H3

描述信息

C254 - Anti-Infective Agent > C258 - Antibiotic

同义名列表

3 个代谢物同义名

Resistomycin; heliomycin; Resistomycin



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

6 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 AFP, AIMP2, BCL2, BIRC5, CCNB1, CCND1, CTNNB1, HDAC1, HDAC2, HDAC3, MYC, SIRT1
Golgi apparatus, trans-Golgi network membrane 1 LRBA
Endoplasmic reticulum membrane 2 BCL2, LRBA
Nucleus 14 AIMP2, BCL2, BIRC5, CCNB1, CCND1, CTNNB1, HDAC1, HDAC2, HDAC3, MYC, PCNA, SIRT1, SP9, TCF4
cytosol 10 AIMP2, BCL2, BIRC5, CCNB1, CCND1, CTNNB1, HDAC1, HDAC3, LRBA, SIRT1
nuclear body 1 PCNA
centrosome 4 CCNB1, CCND1, CTNNB1, PCNA
nucleoplasm 12 ATP2B1, BIRC5, CCNB1, CCND1, CTNNB1, HDAC1, HDAC2, HDAC3, MYC, PCNA, SIRT1, TCF4
Cell membrane 4 ATP2B1, CTNNB1, LRBA, SLC7A1
lamellipodium 1 CTNNB1
Multi-pass membrane protein 2 ATP2B1, SLC7A1
Synapse 2 ATP2B1, CTNNB1
cell cortex 1 CTNNB1
cell junction 1 CTNNB1
glutamatergic synapse 2 ATP2B1, CTNNB1
Golgi apparatus 2 HDAC3, LRBA
lysosomal membrane 1 LRBA
neuronal cell body 1 HDAC1
presynaptic membrane 2 ATP2B1, CTNNB1
Cytoplasm, cytosol 2 AIMP2, HDAC3
plasma membrane 5 ATP2B1, CTNNB1, HDAC3, LRBA, SLC7A1
synaptic vesicle membrane 1 ATP2B1
Membrane 9 AIMP2, ATP2B1, BCL2, CCNB1, CTNNB1, HDAC2, LRBA, MYC, SLC7A1
apical plasma membrane 1 SLC7A1
basolateral plasma membrane 3 ATP2B1, CTNNB1, SLC7A1
extracellular exosome 4 ATP2B1, CTNNB1, LYZ, PCNA
Lysosome membrane 1 LRBA
endoplasmic reticulum 1 BCL2
extracellular space 2 AFP, LYZ
perinuclear region of cytoplasm 1 CTNNB1
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 2 CCND1, CTNNB1
mitochondrion 3 BCL2, MCAT, SIRT1
protein-containing complex 7 BCL2, BIRC5, CTNNB1, HDAC1, HDAC2, MYC, SLC7A1
intracellular membrane-bounded organelle 1 ATP2B1
chromatin silencing complex 1 SIRT1
ESC/E(Z) complex 1 HDAC2
Secreted 1 AFP
extracellular region 1 LYZ
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 2 BCL2, LRBA
mitochondrial outer membrane 1 BCL2
mitochondrial matrix 2 CCNB1, MCAT
transcription regulator complex 2 CTNNB1, TCF4
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
Nucleus membrane 2 BCL2, CCND1
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, CCND1
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
microtubule cytoskeleton 1 BIRC5
nucleolus 2 MYC, SIRT1
Wnt signalosome 1 CTNNB1
midbody 1 BIRC5
apical part of cell 1 CTNNB1
cell-cell junction 1 CTNNB1
postsynaptic membrane 1 CTNNB1
heterochromatin 2 HDAC1, SIRT1
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 CTNNB1
Cytoplasm, cytoskeleton, spindle 1 BIRC5
focal adhesion 1 CTNNB1
microtubule 1 BIRC5
spindle 1 BIRC5
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
Nucleus, PML body 2 SIRT1, TCF4
PML body 2 SIRT1, TCF4
fascia adherens 1 CTNNB1
lateral plasma membrane 2 ATP2B1, CTNNB1
interphase microtubule organizing center 1 BIRC5
nuclear inner membrane 1 SIRT1
chromatin 8 HDAC1, HDAC2, HDAC3, MYC, PCNA, SIRT1, SP9, TCF4
cell projection 1 ATP2B1
cell periphery 1 CTNNB1
mitotic spindle 1 HDAC3
Chromosome 2 BIRC5, HDAC3
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
centriole 1 BIRC5
Nucleus, nucleolus 1 MYC
spindle pole 2 CCNB1, CTNNB1
nuclear replication fork 1 PCNA
chromosome, telomeric region 2 HDAC2, PCNA
nuclear chromosome 1 BIRC5
postsynaptic density, intracellular component 1 CTNNB1
Basolateral cell membrane 1 ATP2B1
microvillus membrane 1 CTNNB1
fibrillar center 1 SIRT1
nuclear envelope 2 MYC, SIRT1
Endomembrane system 1 CTNNB1
Chromosome, centromere 1 BIRC5
Chromosome, centromere, kinetochore 1 BIRC5
Nucleus, nucleoplasm 1 MYC
euchromatin 2 CTNNB1, SIRT1
Presynaptic cell membrane 1 ATP2B1
replication fork 1 PCNA
myelin sheath 1 BCL2
basal plasma membrane 1 SLC7A1
endoplasmic reticulum lumen 1 AFP
transcription repressor complex 3 CCND1, HDAC1, HDAC3
male germ cell nucleus 1 PCNA
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
kinetochore 1 BIRC5
histone deacetylase complex 3 HDAC1, HDAC2, HDAC3
RNA polymerase II transcription repressor complex 1 MYC
beta-catenin-TCF complex 2 CTNNB1, TCF4
azurophil granule lumen 1 LYZ
NuRD complex 2 HDAC1, HDAC2
immunological synapse 1 ATP2B1
chromosome, centromeric region 1 BIRC5
outer kinetochore 1 CCNB1
presynaptic active zone cytoplasmic component 1 CTNNB1
nuclear lamina 1 PCNA
chromosome passenger complex 1 BIRC5
cytoplasmic microtubule 1 BIRC5
Sin3-type complex 2 HDAC1, HDAC2
protein-DNA complex 2 CTNNB1, TCF4
spindle microtubule 1 BIRC5
survivin complex 1 BIRC5
eNoSc complex 1 SIRT1
rDNA heterochromatin 1 SIRT1
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
Rough endoplasmic reticulum 1 MYC
catenin complex 1 CTNNB1
cyclin-dependent protein kinase holoenzyme complex 2 CCND1, PCNA
Myc-Max complex 1 MYC
cyclin B1-CDK1 complex 1 CCNB1
BAD-BCL-2 complex 1 BCL2
photoreceptor ribbon synapse 1 ATP2B1
cyclin D1-CDK4 complex 1 CCND1
PCNA complex 1 PCNA
PCNA-p21 complex 1 PCNA
replisome 1 PCNA
beta-catenin-TCF7L2 complex 2 CTNNB1, TCF4
cyclin D1-CDK6 complex 1 CCND1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
[SirtT1 75 kDa fragment]: Cytoplasm 1 SIRT1
catenin-TCF7L2 complex 1 TCF4
nucleoplasmic reticulum 1 MYC


文献列表

  • Nikita A Slesarchuk, Evgeny V Khvatov, Alexey A Chistov, Gleb V Proskurin, Timofei D Nikitin, Anastasiya I Lazarevich, Angelina A Ulanovskaya, Egor A Ulashchik, Alexey A Orlov, Artjom V Jegorov, Alexey V Ustinov, Anton P Tyurin, Vadim V Shmanai, Aydar A Ishmukhametov, Vladimir A Korshun, Dmitry I Osolodkin, Liubov I Kozlovskaya, Andrey V Aralov. Simplistic perylene-related compounds as inhibitors of tick-borne encephalitis virus reproduction. Bioorganic & medicinal chemistry letters. 2020 05; 30(10):127100. doi: 10.1016/j.bmcl.2020.127100. [PMID: 32199731]
  • Ying-lao Zhang, Shuai Li, Dong-hua Jiang, Li-chun Kong, Ping-hua Zhang, Jia-dong Xu. Antifungal activities of metabolites produced by a termite-associated Streptomyces canus BYB02. Journal of agricultural and food chemistry. 2013 Feb; 61(7):1521-4. doi: 10.1021/jf305210u. [PMID: 23360202]
  • R Vijayabharathi, P Sathyadevi, P Krishnamoorthy, D Senthilraja, P Brunthadevi, S Sathyabama, V Brindha Priyadarisini. Interaction studies of resistomycin from Streptomyces aurantiacus AAA5 with calf thymus DNA and bovine serum albumin. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2012 Apr; 89(?):294-300. doi: 10.1016/j.saa.2011.12.072. [PMID: 22285949]
  • Yoshihito Shiono, Nobuyo Shiono, Shujiro Seo, Syuichi Oka, Yoshimitsu Yamazaki. Effects of polyphenolic anthrone derivatives, resistomycin and hypercin, on apoptosis in human megakaryoblastic leukemia CMK-7 cell line. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2002 Sep; 57(9-10):923-9. doi: 10.1515/znc-2002-9-1028. [PMID: 12440735]