Flavonoid (BioDeep_00000861685)

Main id: BioDeep_00000229882

 

PANOMIX_OTCML-2023


代谢物信息卡片


4H-1-Benzopyran-4-one, 5,6,7-trihydroxy-2-(4-hydroxyphenyl)-

化学式: C15H10O6 (286.0477)
中文名称: 高黄芩素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C=C(C(=C3O)O)O)O
InChI: InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)11-5-9(17)13-12(21-11)6-10(18)14(19)15(13)20/h1-6,16,18-20H

描述信息

Scutellarein is a natural flavonoid compound with anti-inflammatory effects.
Scutellarein is a natural flavonoid compound with anti-inflammatory effects.

同义名列表

18 个代谢物同义名

4H-1-Benzopyran-4-one, 5,6,7-trihydroxy-2-(4-hydroxyphenyl)-; 5,6,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 5,6,7-trihydroxy-2-(4-hydroxyphenyl)-4-chromenone; 5,6,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one; 5,6,7-trihydroxy-2-(4-hydroxyphenyl)chromone; 4,5,6,7-tetrahydroxyflavanone; 6-hydroxyapigenin; Isocarthamidin; Scutellarein; ZINC00899075; AIDS-000486; AIDS000486; ST5331621; Flavonoid; 529-53-3; C10184; 4',5,6,7-Tetrahydroxyflavone; Scutellarein



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

56 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 AKT1, ANXA5, BCL2, CA1, CASP3, CYP1A1, PIK3CA, PTEN, PTGS2, VEGFA
Peripheral membrane protein 5 ACHE, ANXA5, CYP1A1, CYP1B1, PTGS2
Endoplasmic reticulum membrane 7 BCL2, CYP1A1, CYP1B1, PTGS2, UGT1A1, UGT1A3, UGT1A9
Nucleus 6 ACHE, AKT1, BCL2, CASP3, PTEN, VEGFA
cytosol 7 AKT1, ANXA5, BCL2, CA1, CASP3, PIK3CA, PTEN
nucleoplasm 3 AKT1, CASP3, PTEN
Cell membrane 3 ACHE, AKT1, TNF
lamellipodium 2 AKT1, PIK3CA
Multi-pass membrane protein 1 SLC15A1
Synapse 1 ACHE
cell cortex 1 AKT1
cell surface 3 ACHE, TNF, VEGFA
glutamatergic synapse 2 AKT1, CASP3
Golgi apparatus 2 ACHE, VEGFA
lysosomal membrane 1 GAA
mitochondrial inner membrane 1 CYP1A1
neuromuscular junction 1 ACHE
neuronal cell body 2 CASP3, TNF
postsynapse 1 AKT1
sarcolemma 1 ANXA5
Lysosome 1 GAA
plasma membrane 9 ACHE, AKT1, F2, GAA, PIK3CA, PTEN, SLC15A1, TNF, UGT1A1
Membrane 11 ACHE, AKT1, ANXA5, BCL2, CYP1B1, GAA, SLC15A1, UGT1A1, UGT1A3, UGT1A9, VEGFA
apical plasma membrane 2 PTEN, SLC15A1
brush border 1 SLC15A1
caveola 1 PTGS2
extracellular exosome 4 ANXA5, CA1, F2, GAA
Lysosome membrane 1 GAA
endoplasmic reticulum 6 BCL2, PTGS2, UGT1A1, UGT1A3, UGT1A9, VEGFA
extracellular space 5 ACHE, F2, IL6, TNF, VEGFA
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 3 ACHE, PIK3CA, UGT1A1
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 3 BCL2, CYP1A1, CYP1B1
protein-containing complex 3 AKT1, BCL2, PTGS2
intracellular membrane-bounded organelle 3 CYP1A1, CYP1B1, GAA
Microsome membrane 3 CYP1A1, CYP1B1, PTGS2
postsynaptic density 2 CASP3, PTEN
Secreted 5 ACHE, F2, GAA, IL6, VEGFA
extracellular region 8 ACHE, ANXA5, F2, GAA, IL6, PTEN, TNF, VEGFA
cytoplasmic side of plasma membrane 1 PTEN
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 4 BCL2, UGT1A1, UGT1A3, UGT1A9
mitochondrial outer membrane 1 BCL2
Extracellular side 1 ACHE
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 ANXA5, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
dendritic spine 1 PTEN
microtubule cytoskeleton 1 AKT1
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Apical cell membrane 1 SLC15A1
Cytoplasm, perinuclear region 1 UGT1A1
Mitochondrion inner membrane 1 CYP1A1
Membrane raft 1 TNF
pore complex 1 BCL2
focal adhesion 1 ANXA5
spindle 1 AKT1
extracellular matrix 1 VEGFA
basement membrane 1 ACHE
Cell projection, dendritic spine 1 PTEN
Nucleus, PML body 1 PTEN
PML body 1 PTEN
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 2 ANXA5, F2
secretory granule 1 VEGFA
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, neuron projection 1 PTEN
Zymogen granule membrane 1 ANXA5
neuron projection 2 PTEN, PTGS2
ciliary basal body 1 AKT1
cell projection 1 PTEN
phagocytic cup 1 TNF
blood microparticle 1 F2
Lipid-anchor, GPI-anchor 1 ACHE
tertiary granule membrane 1 GAA
side of membrane 1 ACHE
myelin sheath 1 BCL2
Golgi lumen 1 F2
endoplasmic reticulum lumen 3 F2, IL6, PTGS2
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
azurophil granule membrane 1 GAA
Schmidt-Lanterman incisure 1 PTEN
vesicle membrane 1 ANXA5
synaptic cleft 1 ACHE
ficolin-1-rich granule membrane 1 GAA
death-inducing signaling complex 1 CASP3
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
endoplasmic reticulum chaperone complex 1 UGT1A1
myelin sheath adaxonal region 1 PTEN
endothelial microparticle 1 ANXA5
autolysosome lumen 1 GAA
BAD-BCL-2 complex 1 BCL2
[Isoform alpha]: Secreted 1 PTEN
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Isoform H]: Cell membrane 1 ACHE
cytochrome complex 1 UGT1A1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Guangjun Yu, Yichun Shi, Shiqin Cong, Chengxun Wu, Jing Liu, Yanghui Zhang, Hongyan Liu, Xiuxiu Liu, Haixing Deng, Zhenghuai Tan, Yong Deng. Synthesis and evaluation of butylphthalide-scutellarein hybrids as multifunctional agents for the treatment of Alzheimer's disease. European journal of medicinal chemistry. 2024 Feb; 265(?):116099. doi: 10.1016/j.ejmech.2023.116099. [PMID: 38160618]
  • Lu Liu, Yunsen Zhang, Lun Wang, Yue Liu, Hongqing Chen, Qiongying Hu, Chunguang Xie, Xianli Meng, Xiaofei Shen. Scutellarein alleviates chronic obstructive pulmonary disease through inhibition of ferroptosis by chelating iron and interacting with arachidonate 15-lipoxygenase. Phytotherapy research : PTR. 2023 Oct; 37(10):4587-4606. doi: 10.1002/ptr.7928. [PMID: 37353982]
  • Yujing Wang, Liaoxi Tan, Kejun Jiao, Chu Xue, Qinglian Tang, Shan Jiang, Younan Ren, Hao Chen, Tarek Mohamed Abd El-Aziz, Khalid N M Abdelazeem, Ye Yu, Fang Zhao, Michael X Zhu, Zhengyu Cao. Scutellarein attenuates atopic dermatitis by selectively inhibiting transient receptor potential vanilloid 3 channels. British journal of pharmacology. 2022 10; 179(20):4792-4808. doi: 10.1111/bph.15913. [PMID: 35771623]
  • Min Yeong Park, Sang Eun Ha, Hun Hwan Kim, Pritam Bhagwan Bhosale, Abuyaseer Abusaliya, Se Hyo Jeong, Joon-Suk Park, Jeong Doo Heo, Gon Sup Kim. Scutellarein Inhibits LPS-Induced Inflammation through NF-κB/MAPKs Signaling Pathway in RAW264.7 Cells. Molecules (Basel, Switzerland). 2022 Jun; 27(12):. doi: 10.3390/molecules27123782. [PMID: 35744907]
  • Ivana M P Violante, Carlos A Carollo, Larissa I Silva, Adna Q C Oliveira, Flavia C Pardinho, Walmir Silva Garcez, Fernanda R Garcez, Ruberlei Godinho de Oliveira, Karuppusamy Arunachalam, Domingos Tabajara de Oliveira Martins. Cytotoxicity and antibacterial activity of scutellarein and carajurone-enriched fraction obtained from the hydroethanolic extract of the leaves of Fridericia chica (Bonpl.) L.G. Lohmann. Natural product research. 2021 Dec; 35(23):5287-5293. doi: 10.1080/14786419.2020.1753050. [PMID: 32290696]
  • Dong Liu, Cuijie Zhang, Min Hu, Kangle Su. Scutellarein relieves the death and inflammation of tubular epithelial cells in ischemic kidney injury by degradation of COX-2 protein. International immunopharmacology. 2021 Dec; 101(Pt A):108193. doi: 10.1016/j.intimp.2021.108193. [PMID: 34619498]
  • Dongni Ji, Jianhua Li, Fanglin Xu, Yuhong Ren, Yong Wang. Improve the Biosynthesis of Baicalein and Scutellarein via Manufacturing Self-Assembly Enzyme Reactor In Vivo. ACS synthetic biology. 2021 05; 10(5):1087-1094. doi: 10.1021/acssynbio.0c00606. [PMID: 33880917]
  • Venu Venkatarame Gowda Saralamma, Preethi Vetrivel, Ho Jeong Lee, Seong Min Kim, Sang Eun Ha, Rajeswari Murugesan, Eun Hee Kim, Jeong Doo Heo, Gon Sup Kim. Comparative proteomic analysis uncovers potential biomarkers involved in the anticancer effect of Scutellarein in human gastric cancer cells. Oncology reports. 2020 09; 44(3):939-958. doi: 10.3892/or.2020.7677. [PMID: 32705238]
  • Yuanzhi Li, Jundong Wang, Sen Zhong, Jun Li, Weiliang Du. Scutellarein inhibits the development of colon cancer via CDC4‑mediated RAGE ubiquitination. International journal of molecular medicine. 2020 Apr; 45(4):1059-1072. doi: 10.3892/ijmm.2020.4496. [PMID: 32124957]
  • Hou-da Zhu, Pan Tian, Liang-Jun Guan, Liang-Mian Chen, Xiao-Qian Liu, Hui-Min Gao, Zhi-Min Wang. [Analysis and structural identification of relevant substances in Breviscapine for Injection]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2020 Mar; 45(6):1350-1356. doi: 10.19540/j.cnki.cjcmm.20200207.309. [PMID: 32281347]
  • Yiguang Lin, Nina Ren, Siyu Li, Ming Chen, Peng Pu. Novel anti-obesity effect of scutellarein and potential underlying mechanism of actions. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Sep; 117(?):109042. doi: 10.1016/j.biopha.2019.109042. [PMID: 31228804]
  • Jianhua Li, Chenfei Tian, Yuhui Xia, Ishmael Mutanda, Kaibo Wang, Yong Wang. Production of plant-specific flavones baicalein and scutellarein in an engineered E. coli from available phenylalanine and tyrosine. Metabolic engineering. 2019 03; 52(?):124-133. doi: 10.1016/j.ymben.2018.11.008. [PMID: 30496827]
  • He-Min Li, Ting Gu, Wen-Yu Wu, Shao-Peng Yu, Tian-Yuan Fan, Yue Zhong, Nian-Guang Li. Synthesis and Biological Evaluation of Scutellarein Alkyl Derivatives as Preventing Neurodegenerative Agents with Improved Lipid Soluble Properties. Medicinal chemistry (Shariqah (United Arab Emirates)). 2019; 15(7):771-780. doi: 10.2174/1573406414666181015143551. [PMID: 30324887]
  • Lin Shi, Yi Wu, Dian Liang Lv, Lei Feng. Scutellarein selectively targets multiple myeloma cells by increasing mitochondrial superoxide production and activating intrinsic apoptosis pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Jan; 109(?):2109-2118. doi: 10.1016/j.biopha.2018.09.024. [PMID: 30551468]
  • Nourah Zoman Alzoman, Hadir Mohamed Maher, Hessa Al-Showiman, Ghada Ahmed Fawzy, Areej Mohammad Al-Taweel, Shagufta Perveen, Rasool Bakhsh Tareen, Ruba Mahmoud Al-Sabbagh. CE-DAD Determination of Scutellarein and Caffeic Acid in Abelia triflora Crude Extract. Journal of chromatographic science. 2018 Sep; 56(8):746-752. doi: 10.1093/chromsci/bmy042. [PMID: 29750262]
  • Siying Chen, Mei Li, Yueting Li, Hejia Hu, Ying Li, Yong Huang, Lin Zheng, Yuan Lu, Jie Hu, Yanyu Lan, Aimin Wang, Yongjun Li, Zipeng Gong, Yonglin Wang. A UPLC-ESI-MS/MS Method for Simultaneous Quantitation of Chlorogenic Acid, Scutellarin, and Scutellarein in Rat Plasma: Application to a Comparative Pharmacokinetic Study in Sham-Operated and MCAO Rats after Oral Administration of Erigeron breviscapus Extract. Molecules (Basel, Switzerland). 2018 Jul; 23(7):. doi: 10.3390/molecules23071808. [PMID: 30037063]
  • François Chassagne, Mohamed Haddad, Aurélien Amiel, Chiobouaphong Phakeovilay, Chanthanom Manithip, Geneviève Bourdy, Eric Deharo, Guillaume Marti. A metabolomic approach to identify anti-hepatocarcinogenic compounds from plants used traditionally in the treatment of liver diseases. Fitoterapia. 2018 Jun; 127(?):226-236. doi: 10.1016/j.fitote.2018.02.021. [PMID: 29477305]
  • Guanghui Ni, Yanling Tang, Minxin Li, Yuefeng He, Gaoxiong Rao. Synthesis of Scutellarein Derivatives with a Long Aliphatic Chain and Their Biological Evaluation against Human Cancer Cells. Molecules (Basel, Switzerland). 2018 Feb; 23(2):. doi: 10.3390/molecules23020310. [PMID: 29389889]
  • Lin You, Hong Zhu, Chun Wang, Fang Wang, Yongjun Li, Yan Li, Yonglin Wang, Bin He. Scutellarin inhibits Hela cell growth and glycolysis by inhibiting the activity of pyruvate kinase M2. Bioorganic & medicinal chemistry letters. 2017 12; 27(24):5404-5408. doi: 10.1016/j.bmcl.2017.11.011. [PMID: 29157862]
  • V F Kulikovskii, E T Zhilyakova, O O Novikov, D I Pisarev, N V Prokushchenko, L L Ivanova. Study of Sedative Tea Phytocomplex within the Framework of Studies Aimed at Creation of a Rectal Dosage Form with Antihistaminic Effect. Bulletin of experimental biology and medicine. 2017 Oct; 163(6):753-756. doi: 10.1007/s10517-017-3896-6. [PMID: 29063320]
  • Yelin Kang, Bong-Gyu Kim, Sunghoon Kim, Youngshim Lee, Youngdae Yoon. Inhibitory potential of flavonoids on PtdIns(3,4,5)P3 binding with the phosphoinositide-dependent kinase 1 pleckstrin homology domain. Bioorganic & medicinal chemistry letters. 2017 02; 27(3):420-426. doi: 10.1016/j.bmcl.2016.12.051. [PMID: 28049590]
  • Xiaoxuan Tian, Lianying Chang, Guangyin Ma, Taiyi Wang, Ming Lv, Zhilong Wang, Liping Chen, Yuefei Wang, Xiumei Gao, Yan Zhu. Delineation of Platelet Activation Pathway of Scutellarein Revealed Its Intracellular Target as Protein Kinase C. Biological & pharmaceutical bulletin. 2016; 39(2):181-91. doi: 10.1248/bpb.b15-00511. [PMID: 26581323]
  • Hao Tang, Zhi-Hao Shi, Nian-Guang Li, Yu-Ping Tang, Qian-Ping Shi, Ze-Xi Dong, Peng-Xuan Zhang, Jin-Ao Duan. Investigation on the interactions of scutellarin and scutellarein with bovine serum albumin using spectroscopic and molecular docking techniques. Archives of pharmacal research. 2015 Oct; 38(10):1789-801. doi: 10.1007/s12272-014-0541-z. [PMID: 25577334]
  • Yearam Jung, Soon Young Shin, Yeonjoong Yong, Hyeryoung Jung, Seunghyun Ahn, Young Han Lee, Yoongho Lim. Plant-derived flavones as inhibitors of aurora B kinase and their quantitative structure-activity relationships. Chemical biology & drug design. 2015 May; 85(5):574-85. doi: 10.1111/cbdd.12445. [PMID: 25298094]
  • Zhipei Sang, Xiaoming Qiang, Yan Li, Wen Yuan, Qiang Liu, Yikun Shi, Wei Ang, Youfu Luo, Zhenghuai Tan, Yong Deng. Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease. European journal of medicinal chemistry. 2015 Apr; 94(?):348-66. doi: 10.1016/j.ejmech.2015.02.063. [PMID: 25778991]
  • Hao Tang, Yuping Tang, Nian-Guang Li, Hang Lin, Weixia Li, Qianping Shi, Wei Zhang, Pengxuan Zhang, Zexi Dong, Minzhe Shen, Ting Gu, Jin-Ao Duan. Comparative Metabolomic Analysis of the Neuroprotective Effects of Scutellarin and Scutellarein against Ischemic Insult. PloS one. 2015; 10(7):e0131569. doi: 10.1371/journal.pone.0131569. [PMID: 26147971]
  • Kasumi Nakamura, Jia-Hua Yang, Eiji Sato, Naoyuki Miura, Yi-Xin Wu. Effects of Hydroxy Groups in the A-Ring on the Anti-proteasome Activity of Flavone. Biological & pharmaceutical bulletin. 2015; 38(6):935-40. doi: 10.1248/bpb.b15-00018. [PMID: 25810454]
  • Xiao Yang, Xiaoqing Miao, Fangrui Cao, Shang Li, Nana Ai, Qi Chang, Simon M Y Lee, Ying Zheng. Nanosuspension development of scutellarein as an active and rapid orally absorbed precursor of its BCS class IV glycoside scutellarin. Journal of pharmaceutical sciences. 2014 Nov; 103(11):3576-3584. doi: 10.1002/jps.24149. [PMID: 25187229]
  • Xin Wang, Hongjun Xia, Youping Liu, Feng Qiu, Xin Di. Simultaneous determination of three glucuronide conjugates of scutellarein in rat plasma by LC-MS/MS for pharmacokinetic study of breviscapine. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Aug; 965(?):79-84. doi: 10.1016/j.jchromb.2014.06.013. [PMID: 24999248]
  • Qing Liu, Qi-Ming Yang, Hai-Jun Hu, Li Yang, Ying-Bo Yang, Gui-Xin Chou, Zheng-Tao Wang. Bioactive diterpenoids and flavonoids from the aerial parts of Scoparia dulcis. Journal of natural products. 2014 Jul; 77(7):1594-600. doi: 10.1021/np500150f. [PMID: 24955889]
  • Guang-You Ma, Yun-Feng Cao, Cui-Min Hu, Zhong-Ze Fang, Xiao-Yu Sun, Mo Hong, Zhi-Tu Zhu. Comparison of inhibition capability of scutellarein and scutellarin towards important liver UDP-glucuronosyltransferase (UGT) isoforms. Phytotherapy research : PTR. 2014 Mar; 28(3):382-6. doi: 10.1002/ptr.4990. [PMID: 23620377]
  • Z Shu-Yao, J Hong, L Chao-Xian, Z Zhi-Wei, Xin Dai-Shan, C Lei. In vitro evidence of possible influence of scutellarein towards bile acids' metabolism. African health sciences. 2013 Sep; 13(3):556-9. doi: 10.4314/ahs.v13i3.4. [PMID: 24250288]
  • Yun-Ze Yin, Rui-Shan Wang, Ri-Dao Chen, Li-Rui Qiao, Lin Yang, Chun-Mei Wang, Jun-Gui Dai. [Chemical constituents from cell suspension cultures of Cudrania tricuspidata]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Dec; 37(24):3734-7. doi: . [PMID: 23627169]
  • Chunying Gao, Hongjian Zhang, Zitao Guo, Tiangeng You, Xiaoyan Chen, Dafang Zhong. Mechanistic studies on the absorption and disposition of scutellarin in humans: selective OATP2B1-mediated hepatic uptake is a likely key determinant for its unique pharmacokinetic characteristics. Drug metabolism and disposition: the biological fate of chemicals. 2012 Oct; 40(10):2009-20. doi: 10.1124/dmd.112.047183. [PMID: 22822035]
  • Jing Xu, Li Yang, Shu-Juan Zhao, Zheng-Tao Wang, Zhi-Bi Hu. An efficient way from naringenin to carthamidine and isocarthamidine by Aspergillus niger. World journal of microbiology & biotechnology. 2012 Apr; 28(4):1803-6. doi: 10.1007/s11274-011-0934-9. [PMID: 22805963]
  • Vivian Chen, Richard E Staub, Scott Baggett, Ramesh Chimmani, Mary Tagliaferri, Isaac Cohen, Emma Shtivelman. Identification and analysis of the active phytochemicals from the anti-cancer botanical extract Bezielle. PloS one. 2012; 7(1):e30107. doi: 10.1371/journal.pone.0030107. [PMID: 22272282]
  • T Balasubramanian, Tapan Kumar Chatterjee, G P Senthilkumar, Tamizh Mani. Effect of potent ethyl acetate fraction of Stereospermum suaveolens extract in streptozotocin-induced diabetic rats. TheScientificWorldJournal. 2012; 2012(?):413196. doi: 10.1100/2012/413196. [PMID: 22593683]
  • Luciana Cristina Borges Fernandes, Carlos Campos Câmara, Benito Soto-Blanco. Anticonvulsant Activity of Extracts of Plectranthus barbatus Leaves in Mice. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):860153. doi: 10.1155/2012/860153. [PMID: 21716675]
  • Rosa Martha Perez Gutierrez, Irasema Anaya Sosa, Carlos Hoyo Vadillo, Teresa Cruz Victoria. Effect of flavonoids from Prosthechea michuacana on carbon tetrachloride induced acute hepatotoxicity in mice. Pharmaceutical biology. 2011 Nov; 49(11):1121-7. doi: 10.3109/13880209.2011.570766. [PMID: 22014261]
  • I Borrás Linares, D Arráez-Román, M Herrero, E Ibáñez, A Segura-Carretero, A Fernández-Gutiérrez. Comparison of different extraction procedures for the comprehensive characterization of bioactive phenolic compounds in Rosmarinus officinalis by reversed-phase high-performance liquid chromatography with diode array detection coupled to electrospray time-of-flight mass spectrometry. Journal of chromatography. A. 2011 Oct; 1218(42):7682-90. doi: 10.1016/j.chroma.2011.07.021. [PMID: 21835416]
  • Harminder, V Singh, A K Chaudhary. A Review on the Taxonomy, Ethnobotany, Chemistry and Pharmacology of Oroxylum indicum Vent. Indian journal of pharmaceutical sciences. 2011 Sep; 73(5):483-90. doi: 10.4103/0250-474x.98981. [PMID: 22923859]
  • Yongjiang Wu, Ye Jin, Haiying Ding, Lianjun Luan, Yong Chen, Xuesong Liu. In-line monitoring of extraction process of scutellarein from Erigeron breviscapus (vant.) Hand-Mazz based on qualitative and quantitative uses of near-infrared spectroscopy. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2011 Sep; 79(5):934-9. doi: 10.1016/j.saa.2011.03.056. [PMID: 21561801]
  • Jian-feng Xing, Hai-sheng You, Ya-lin Dong, Jun Lu, Si-ying Chen, Hui-fang Zhu, Qian Dong, Mao-yi Wang, Wei-hua Dong. Metabolic and pharmacokinetic studies of scutellarin in rat plasma, urine, and feces. Acta pharmacologica Sinica. 2011 May; 32(5):655-63. doi: 10.1038/aps.2011.11. [PMID: 21516133]
  • Elizabeth A Mazzio, Fran Close, Karam F A Soliman. The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. International journal of molecular sciences. 2011 Jan; 12(1):506-69. doi: 10.3390/ijms12010506. [PMID: 21340000]
  • Juliana I Dos Santos, Fábio F Cardoso, Andreimar M Soares, Maeli Dal Pai Silva, Márcia Gallacci, Marcos R M Fontes. Structural and functional studies of a bothropic myotoxin complexed to rosmarinic acid: new insights into Lys49-PLA₂ inhibition. PloS one. 2011; 6(12):e28521. doi: 10.1371/journal.pone.0028521. [PMID: 22205953]
  • Muthu Kumaradoss Mohan Maruga Raja, Shri Hari Mishra. Comprehensive review of Clerodendrum phlomidis: a traditionally used bitter. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. 2010 Jun; 8(6):510-24. doi: 10.3736/jcim20100602. [PMID: 20550872]
  • Yerra Koteswara Rao, Shih-Hua Fang, Shih-Chuan Hsieh, Tsung-Hsien Yeh, Yew-Min Tzeng. The constituents of Anisomeles indica and their anti-inflammatory activities. Journal of ethnopharmacology. 2009 Jan; 121(2):292-6. doi: 10.1016/j.jep.2008.10.032. [PMID: 19041702]
  • Prahlad Parajuli, Nirmal Joshee, Agnes M Rimando, Sandeep Mittal, Anand K Yadav. In vitro antitumor mechanisms of various Scutellaria extracts and constituent flavonoids. Planta medica. 2009 Jan; 75(1):41-8. doi: 10.1055/s-0028-1088364. [PMID: 19031366]
  • Linghua Meng, Yves F Lozano, Emile M Gaydou, Bin Li. Antioxidant activities of polyphenols extracted from Perilla frutescens varieties. Molecules (Basel, Switzerland). 2008 Dec; 14(1):133-40. doi: 10.3390/molecules14010133. [PMID: 19127243]
  • Y H Tao, D Y Jiang, H B Xu, X L Yang. Inhibitory effect of Erigeron breviscapus extract and its flavonoid components on GABA shunt enzymes. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2008 Jan; 15(1-2):92-7. doi: 10.1016/j.phymed.2007.06.009. [PMID: 17689232]
  • Lin Yang, Xiao-Yu Guo, Li-Yi Pan, Hong He, Jin-Lan Zhang, Pei-Qi Wang, Qing-Ming Che, Qi-Shi Sun. Metabolites of scutellarein in rat plasma. Journal of Asian natural products research. 2008 Jan; 10(1-2):59-64. doi: 10.1080/10286020701275804. [PMID: 18058381]
  • HongJun Xia, Feng Qiu, Shan Zhu, TieYing Zhang, GeXia Qu, XinSheng Yao. Isolation and identification of ten metabolites of breviscapine in rat urine. Biological & pharmaceutical bulletin. 2007 Jul; 30(7):1308-16. doi: 10.1248/bpb.30.1308. [PMID: 17603172]
  • Feng Qiu, HongJun Xia, TieYing Zhang, Xin Di, Gexia Qu, XinSheng Yao. Two major urinary metabolites of scutellarin in rats. Planta medica. 2007 Apr; 73(4):363-5. doi: 10.1055/s-2007-967128. [PMID: 17354170]
  • Qing-Ming Che, Ying Chen, Li-Yi Pan, Hong He. [Study on bile excretion of scutellarein]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2006 Oct; 31(20):1710-2. doi: . [PMID: 17225543]
  • Xiaoyan Chen, Liang Cui, Xiaotao Duan, Bin Ma, Dafang Zhong. Pharmacokinetics and metabolism of the flavonoid scutellarin in humans after a single oral administration. Drug metabolism and disposition: the biological fate of chemicals. 2006 Aug; 34(8):1345-52. doi: 10.1124/dmd.106.009779. [PMID: 16714374]
  • Jianming Huang, Ni Li, Yunqiu Yu, Weiyu Weng, Xubing Huang. Determination of aglycone conjugated metabolites of scutellarin in rat plasma by HPLC. Journal of pharmaceutical and biomedical analysis. 2006 Feb; 40(2):465-71. doi: 10.1016/j.jpba.2005.07.051. [PMID: 16181763]
  • Joo-Heon Yoon, Seung Joon Baek. Molecular targets of dietary polyphenols with anti-inflammatory properties. Yonsei medical journal. 2005 Oct; 46(5):585-96. doi: 10.3349/ymj.2005.46.5.585. [PMID: 16259055]
  • David Goh, Yian Hoon Lee, Eng Shi Ong. Inhibitory effects of a chemically standardized extract from Scutellaria barbata in human colon cancer cell lines, LoVo. Journal of agricultural and food chemistry. 2005 Oct; 53(21):8197-204. doi: 10.1021/jf051506+. [PMID: 16218664]
  • J M Huang, W Y Weng, X B Huang, Y H Ji, E Chen. Pharmacokinetics of scutellarin and its aglycone conjugated metabolites in rats. European journal of drug metabolism and pharmacokinetics. 2005 Jul; 30(3):165-70. doi: 10.1007/bf03190615. [PMID: 16250252]
  • Xiuhua Hao, Gang Cheng, Jin Sun, Meijuan Zou, Jie Yu, Shuang Zhang, Fude Cui. Validation of an HPLC method for the determination of scutellarin in rat plasma and its pharmacokinetics. Journal of pharmaceutical and biomedical analysis. 2005 Jun; 38(2):360-3. doi: 10.1016/j.jpba.2005.01.004. [PMID: 15925232]
  • Hao Hong, Guo-Qing Liu. Protection against hydrogen peroxide-induced cytotoxicity in PC12 cells by scutellarin. Life sciences. 2004 Apr; 74(24):2959-73. doi: 10.1016/j.lfs.2003.09.074. [PMID: 15051420]
  • Jin-Lan Zhang, Qing-Min Che, Shou-Zhuo Li, Tong-Hui Zhou. Study on metabolism of scutellarin in rats by HPLC-MS and HPLC-NMR. Journal of Asian natural products research. 2003 Dec; 5(4):249-56. doi: 10.1080/1028602031000105858. [PMID: 14604233]
  • Yi-ming Liu, Ai-hua Lin, Hui Chen, Fan-dian Zeng. Study on pharmacokinetics of scutellarin in rabbits. Yao xue xue bao = Acta pharmaceutica Sinica. 2003 Oct; 38(10):775-8. doi: NULL. [PMID: 14730903]
  • Christine A Williams, Jeffrey B Harborne, Jenny R Greenham, Renée J Grayer, Geoffrey C Kite, John Eagles. Variations in lipophilic and vacuolar flavonoids among European Pulicaria species. Phytochemistry. 2003 Sep; 64(1):275-83. doi: 10.1016/s0031-9422(03)00207-3. [PMID: 12946426]
  • Hidenori Kuwabara, Kyoko Mouri, Hideaki Otsuka, Ryoji Kasai, Kazuo Yamasaki. Tricin from a malagasy connaraceous plant with potent antihistaminic activity. Journal of natural products. 2003 Sep; 66(9):1273-5. doi: 10.1021/np030020p. [PMID: 14510616]
  • Xiao-dong Bie. [Clinical observation on treatment of traumatic intracranial hematoma by Flos carthami combined with radix Acanthopanacis senticosi injection]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2003 Apr; 23(4):296-7. doi: ". [PMID: 12764917]
  • Jenny Greenham, Jeffrey B Harborne, Christine A Williams. Identification of lipophilic flavones and flavonols by comparative HPLC, TLC and UV spectral analysis. Phytochemical analysis : PCA. 2003 Mar; 14(2):100-18. doi: 10.1002/pca.693. [PMID: 12693635]
  • Zhao Feng Peng, Dieter Strack, Alfred Baumert, Ramanathan Subramaniam, Ngoh Khang Goh, Tet Fatt Chia, Swee Ngin Tan, Lian Sai Chia. Antioxidant flavonoids from leaves of Polygonum hydropiper L. Phytochemistry. 2003 Jan; 62(2):219-28. doi: 10.1016/s0031-9422(02)00504-6. [PMID: 12482460]
  • Hongyan Wang, Kwok-Min Hui, Yingjie Chen, Suixu Xu, J Tze-Fei Wong, Hong Xue. Structure-activity relationships of flavonoids, isolated from Scutellaria baicalensis, binding to benzodiazepine site of GABA(A) receptor complex. Planta medica. 2002 Dec; 68(12):1059-62. doi: 10.1055/s-2002-36357. [PMID: 12494329]
  • Shuang-Cheng Ma, Jiang Du, Paul Pui-Hay But, Xue-Long Deng, Yong-Wen Zhang, Vincent Eng-Choon Ooi, Hong-Xi Xu, Spencer Hon-Sun Lee, Song Fong Lee. Antiviral Chinese medicinal herbs against respiratory syncytial virus. Journal of ethnopharmacology. 2002 Feb; 79(2):205-11. doi: 10.1016/s0378-8741(01)00389-0. [PMID: 11801383]
  • Y O Kim, K Leem, J Park, P Lee, D K Ahn, B C Lee, H K Park, K Suk, S Y Kim, H Kim. Cytoprotective effect of Scutellaria baicalensis in CA1 hippocampal neurons of rats after global cerebral ischemia. Journal of ethnopharmacology. 2001 Oct; 77(2-3):183-8. doi: 10.1016/s0378-8741(01)00283-5. [PMID: 11535362]
  • Z Gao, K Huang, H Xu. Protective effects of flavonoids in the roots of Scutellaria baicalensis Georgi against hydrogen peroxide-induced oxidative stress in HS-SY5Y cells. Pharmacological research. 2001 Feb; 43(2):173-8. doi: 10.1006/phrs.2000.0761. [PMID: 11243719]
  • W D Zhang, W S Chen, Y H Wang, W Y Liu, D Y Kong, H T Li. [Studies on flavone constituents of Erigeron breviscapus (Vant.) Hand.-Mazz]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2000 Sep; 25(9):536-8. doi: ". [PMID: 12516462]
  • Y Komoda, H Chujo, S Ishihara, M Uchida. HPLC quantitative analysis of plantaginin in Shazenso (Plantago asiatica L.) extracts and isolation of plantamajoside. Iyo Kizai Kenkyujo hokoku. Reports of the Institute for Medical and Dental Engineering, Tokyo Medical and Dental University. 1989; 23(?):81-5. doi: . [PMID: 2488968]
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